Frances M. Ashcroft - Publications

University of Oxford, Oxford, United Kingdom 
ion channels

253 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Sachse G, Haythorne E, Hill T, Proks P, Joynson R, Terrón-Expósito R, Bentley L, Tucker SJ, Cox RD, Ashcroft FM. The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion. Diabetes. PMID 33568422 DOI: 10.2337/db20-0691  0.591
2020 Sachse G, Haythorne E, Proks P, Stewart M, Cater H, Ellard S, Davies B, Ashcroft FM. Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice. Wellcome Open Research. 5: 15. PMID 34368464 DOI: 10.12688/wellcomeopenres.15529.2  0.36
2020 Pipatpolkai T, Usher S, Stansfeld PJ, Ashcroft FM. New insights into K channel gene mutations and neonatal diabetes mellitus. Nature Reviews. Endocrinology. PMID 32376986 DOI: 10.1038/S41574-020-0351-Y  0.552
2020 Usher SG, Ashcroft FM, Puljung MC. Nucleotide inhibition of the pancreatic ATP-sensitive K channel explored with patch-clamp fluorometry. Elife. 9. PMID 31909710 DOI: 10.7554/Elife.52775  0.482
2019 Haythorne E, Rohm M, van de Bunt M, Brereton MF, Tarasov AI, Blacker TS, Sachse G, Silva Dos Santos M, Terron Exposito R, Davis S, Baba O, Fischer R, Duchen MR, Rorsman P, MacRae JI, ... Ashcroft FM, et al. Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells. Nature Communications. 10: 2474. PMID 31171772 DOI: 10.1038/S41467-019-10189-X  0.345
2019 Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, ... ... Ashcroft FM, et al. Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion. Nature Communications. 10: 139. PMID 30635569 DOI: 10.1038/S41467-018-08193-8  0.553
2018 Knudsen JG, Hamilton A, Ramracheya R, Tarasov AI, Brereton M, Haythorne E, Chibalina MV, Spégel P, Mulder H, Zhang Q, Ashcroft FM, Adam J, Rorsman P. Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production. Cell Metabolism. PMID 30415925 DOI: 10.1016/J.Cmet.2018.10.003  0.411
2018 Vedovato N, Rorsman O, Hennis K, Ashcroft FM, Proks P. Role of the C-terminus of SUR in the differential regulation of β-cell and cardiac K channels by MgADP and metabolism. The Journal of Physiology. PMID 30179258 DOI: 10.1113/Jp276708  0.521
2018 Misra S, Vedovato N, Cliff E, De Franco E, Hattersley AT, Ashcroft FM, Oliver NS. Permanent neonatal diabetes: combining sulfonylureas with insulin may be an effective treatment. Diabetic Medicine : a Journal of the British Diabetic Association. PMID 29896782 DOI: 10.1111/Dme.13758  0.317
2018 Proks P, Kramer H, Haythorne E, Ashcroft FM. Binding of sulphonylureas to plasma proteins - A KATP channel perspective. Plos One. 13: e0197634. PMID 29772022 DOI: 10.1371/Journal.Pone.0197634  0.431
2018 Rorsman P, Ashcroft FM. Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men. Physiological Reviews. 98: 117-214. PMID 29212789 DOI: 10.1152/Physrev.00008.2017  0.363
2017 Adam J, Ramracheya R, Chibalina MV, Ternette N, Hamilton A, Tarasov AI, Zhang Q, Rebelato E, Rorsman NJG, Martín-Del-Río R, Lewis A, Özkan G, Do HW, Spégel P, Saitoh K, ... ... Ashcroft FM, et al. Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes. Cell Reports. 20: 3135-3148. PMID 28954230 DOI: 10.1016/J.Celrep.2017.08.093  0.36
2017 Flanagan S, Dũng VC, Houghton J, De Franco E, Ngoc CTB, Damhuis A, Ashcroft F, Harries L, Ellard S. An ABCC8 nonsense mutation causing neonatal diabetes through altered transcript expression. Journal of Clinical Research in Pediatric Endocrinology. PMID 28663158 DOI: 10.4274/Jcrpe.4624  0.441
2017 Ashcroft FM, Puljung MC, Vedovato N. Neonatal Diabetes and the KATP Channel: From Mutation to Therapy. Trends in Endocrinology and Metabolism: Tem. PMID 28262438 DOI: 10.1016/J.Tem.2017.02.003  0.457
2016 Brereton MF, Rohm M, Shimomura K, Holland C, Tornovsky-Babeay S, Dadon D, Iberl M, Chibalina MV, Lee S, Glaser B, Dor Y, Rorsman P, Clark A, Ashcroft FM. Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells. Nature Communications. 7: 13496. PMID 27882918 DOI: 10.1038/Ncomms13496  0.334
2016 Dahan T, Ziv O, Horwitz E, Zemmour H, Lavi J, Swisa A, Leibowitz G, Ashcroft FM, Veld PI, Glaser B, Dor Y. Pancreatic Beta Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes. Diabetes. PMID 27864307 DOI: 10.2337/Db16-0641  0.347
2016 Proks P, Puljung MC, Vedovato N, Sachse G, Mulvaney R, Ashcroft FM. Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 371. PMID 27377720 DOI: 10.1098/Rstb.2015.0426  0.515
2016 Vedovato N, Cliff E, Proks P, Poovazhagi V, Flanagan SE, Ellard S, Hattersley AT, Ashcroft FM. Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk. Diabetologia. PMID 27118464 DOI: 10.1007/S00125-016-3964-X  0.452
2016 Babiker T, Vedovato N, Patel K, Thomas N, Finn R, Männikkö R, Chakera AJ, Flanagan SE, Shepherd MH, Ellard S, Ashcroft FM, Hattersley AT. Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes. Diabetologia. PMID 27033559 DOI: 10.1007/S00125-016-3921-8  0.381
2015 Vedovato N, Ashcroft FM, Puljung MC. The Nucleotide-Binding Sites of SUR1: A Mechanistic Model. Biophysical Journal. 109: 2452-60. PMID 26682803 DOI: 10.1016/J.Bpj.2015.10.026  0.52
2015 O'Connell SM, Proks P, Kramer H, Mattis KK, Sachse G, Joyce C, Houghton JA, Ellard S, Hattersley AT, Ashcroft FM, O'Riordan SM. The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutation. Clinical Case Reports. 3: 884-7. PMID 26509030 DOI: 10.1002/Ccr3.370  0.357
2015 Lahmann C, Kramer HB, Ashcroft FM. Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents. Plos One. 10: e0134476. PMID 26225433 DOI: 10.1371/Journal.Pone.0134476  0.365
2014 Proks P, de Wet H, Ashcroft FM. Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic study. The Journal of General Physiology. 144: 469-86. PMID 25348414 DOI: 10.1085/Jgp.201411222  0.566
2014 Zhang Q, Chibalina MV, Bengtsson M, Groschner LN, Ramracheya R, Rorsman NJ, Leiss V, Nassar MA, Welling A, Gribble FM, Reimann F, Hofmann F, Wood JN, Ashcroft FM, Rorsman P. Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression. The Journal of Physiology. 592: 4677-96. PMID 25172946 DOI: 10.1113/Jphysiol.2014.274209  0.573
2014 Brereton MF, Iberl M, Shimomura K, Zhang Q, Adriaenssens AE, Proks P, Spiliotis II, Dace W, Mattis KK, Ramracheya R, Gribble FM, Reimann F, Clark A, Rorsman P, Ashcroft FM. Reversible changes in pancreatic islet structure and function produced by elevated blood glucose. Nature Communications. 5: 4639. PMID 25145789 DOI: 10.1038/Ncomms5639  0.602
2014 Lahmann C, Clark RH, Iberl M, Ashcroft FM. A mutation causing increased KATP channel activity leads to reduced anxiety in mice. Physiology & Behavior. 129: 79-84. PMID 24582665 DOI: 10.1016/J.Physbeh.2014.02.031  0.367
2014 Tornovsky-Babeay S, Dadon D, Ziv O, Tzipilevich E, Kadosh T, Schyr-Ben Haroush R, Hija A, Stolovich-Rain M, Furth-Lavi J, Granot Z, Porat S, Philipson LH, Herold KC, Bhatti TR, Stanley C, ... Ashcroft FM, et al. Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells. Cell Metabolism. 19: 109-21. PMID 24332968 DOI: 10.1016/J.Cmet.2013.11.007  0.396
2013 Brereton MF, Ashcroft FM. Mouse Models of β-cell K Channel Dysfunction. Drug Discovery Today. Disease Models. 10: e101-e109. PMID 29643927 DOI: 10.1016/J.Ddmod.2013.02.001  0.524
2013 Zhang Q, Ramracheya R, Lahmann C, Tarasov A, Bengtsson M, Braha O, Braun M, Brereton M, Collins S, Galvanovskis J, Gonzalez A, Groschner LN, Rorsman NJ, Salehi A, Travers ME, ... ... Ashcroft FM, et al. Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes. Cell Metabolism. 18: 871-82. PMID 24315372 DOI: 10.1016/J.Cmet.2013.10.014  0.661
2013 Ashcroft FM, Rorsman P. K(ATP) channels and islet hormone secretion: new insights and controversies. Nature Reviews. Endocrinology. 9: 660-9. PMID 24042324 DOI: 10.1038/Nrendo.2013.166  0.554
2013 Shimomura K, Tusa M, Iberl M, Brereton MF, Kaizik S, Proks P, Lahmann C, Yaluri N, Modi S, Huopio H, Ustinov J, Otonkoski T, Laakso M, Ashcroft FM. A mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1. Diabetes. 62: 3797-806. PMID 23903354 DOI: 10.2337/Db12-1611  0.425
2013 Proks P, de Wet H, Ashcroft FM. Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes. Diabetes. 62: 3909-19. PMID 23835339 DOI: 10.2337/Db13-0531  0.531
2013 McTaggart JS, Jenkinson N, Brittain JS, Greeley SA, Hattersley AT, Ashcroft FM. Gain-of-function mutations in the K(ATP) channel (KCNJ11) impair coordinated hand-eye tracking. Plos One. 8: e62646. PMID 23626843 DOI: 10.1371/Journal.Pone.0062646  0.332
2013 Loh NY, Bentley L, Dimke H, Verkaart S, Tammaro P, Gorvin CM, Stechman MJ, Ahmad BN, Hannan FM, Piret SE, Evans H, Bellantuono I, Hough TA, Fraser WD, Hoenderop JG, ... Ashcroft FM, et al. Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5. Plos One. 8: e55412. PMID 23383183 DOI: 10.1371/Journal.Pone.0055412  0.343
2013 Fotinou C, Aittoniemi J, de Wet H, Polidori A, Pucci B, Sansom MS, Vénien-Bryan C, Ashcroft FM. Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles. The Febs Journal. 280: 1051-63. PMID 23253866 DOI: 10.1111/Febs.12097  0.396
2012 de Wet H, Shimomura K, Aittoniemi J, Ahmad N, Lafond M, Sansom MS, Ashcroft FM. A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening. The Journal of Physiology. 590: 5025-36. PMID 22802590 DOI: 10.1113/Jphysiol.2012.236075  0.504
2012 Ashcroft FM, Rorsman P. Diabetes mellitus and the β cell: the last ten years. Cell. 148: 1160-71. PMID 22424227 DOI: 10.1016/J.Cell.2012.02.010  0.302
2012 Clark R, Männikkö R, Stuckey DJ, Iberl M, Clarke K, Ashcroft FM. Mice expressing a human K(ATP) channel mutation have altered channel ATP sensitivity but no cardiac abnormalities. Diabetologia. 55: 1195-204. PMID 22252471 DOI: 10.1007/S00125-011-2428-6  0.495
2011 Männikkö R, Flanagan SE, Sim X, Segal D, Hussain K, Ellard S, Hattersley AT, Ashcroft FM. Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes. Diabetes. 60: 1813-22. PMID 21617188 DOI: 10.2337/Db10-1583  0.53
2011 Meadows NA, Saxty B, Albury MS, Kettleborough CA, Ashcroft FM, Moore AL, Cox RD. A high-throughput assay for modulators of NNT activity in permeabilized yeast cells. Journal of Biomolecular Screening. 16: 734-43. PMID 21602486 DOI: 10.1177/1087057111408088  0.357
2011 Männikkö R, Stansfeld PJ, Ashcroft AS, Hattersley AT, Sansom MS, Ellard S, Ashcroft FM. A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated. The Journal of Physiology. 589: 3071-83. PMID 21540348 DOI: 10.1113/Jphysiol.2011.209700  0.523
2011 Porat S, Weinberg-Corem N, Tornovsky-Babaey S, Schyr-Ben-Haroush R, Hija A, Stolovich-Rain M, Dadon D, Granot Z, Ben-Hur V, White P, Girard CA, Karni R, Kaestner KH, Ashcroft FM, Magnuson MA, et al. Control of pancreatic β cell regeneration by glucose metabolism. Cell Metabolism. 13: 440-9. PMID 21459328 DOI: 10.1016/J.Cmet.2011.02.012  0.381
2010 Proks P, de Wet H, Ashcroft FM. Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1. The Journal of General Physiology. 136: 389-405. PMID 20876358 DOI: 10.1085/Jgp.201010475  0.549
2010 Hugill A, Shimomura K, Ashcroft FM, Cox RD. A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose-intolerant phenotype in the mouse. Diabetologia. 53: 2352-6. PMID 20694718 DOI: 10.1007/S00125-010-1866-X  0.412
2010 Clark RH, McTaggart JS, Webster R, Mannikko R, Iberl M, Sim XL, Rorsman P, Glitsch M, Beeson D, Ashcroft FM. Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin. Science (New York, N.Y.). 329: 458-61. PMID 20595581 DOI: 10.1126/Science.1186146  0.463
2010 de Wet H, Fotinou C, Amad N, Dreger M, Ashcroft FM. The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C-terminal 42 amino acids. The Febs Journal. 277: 2654-62. PMID 20553499 DOI: 10.1111/J.1742-464X.2010.07675.X  0.463
2010 Shimomura K, de Nanclares GP, Foutinou C, Caimari M, Castaño L, Ashcroft FM. The first clinical case of a mutation at residue K185 of Kir6.2 (KCNJ11): a major ATP-binding residue. Diabetic Medicine : a Journal of the British Diabetic Association. 27: 225-9. PMID 20546268 DOI: 10.1111/J.1464-5491.2009.02901.X  0.549
2010 McTaggart JS, Clark RH, Ashcroft FM. The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet. The Journal of Physiology. 588: 3201-9. PMID 20519313 DOI: 10.1113/Jphysiol.2010.191767  0.509
2010 Aittoniemi J, de Wet H, Ashcroft FM, Sansom MS. Asymmetric switching in a homodimeric ABC transporter: a simulation study. Plos Computational Biology. 6: e1000762. PMID 20454684 DOI: 10.1371/Journal.Pcbi.1000762  0.322
2010 Ashcroft FM. New uses for old drugs: neonatal diabetes and sulphonylureas. Cell Metabolism. 11: 179-81. PMID 20197050 DOI: 10.1016/J.Cmet.2010.02.004  0.407
2010 Männikkö R, Jefferies C, Flanagan SE, Hattersley A, Ellard S, Ashcroft FM. Interaction between mutations in the slide helix of Kir6.2 associated with neonatal diabetes and neurological symptoms. Human Molecular Genetics. 19: 963-72. PMID 20022885 DOI: 10.1093/Hmg/Ddp554  0.54
2010 Aittoniemi J, Ashcroft FM, Sansom MS. Investigation of Protonation Effects on ATP Binding in ABC Transporters Biophysical Journal. 98: 759a. DOI: 10.1016/J.Bpj.2009.12.4169  0.304
2010 Stansfeld PJ, Hopkinson RJ, Ashcroft FM, Sansom MS. Investigating the PIP2 Binding Site in Kir Channels Via Multi-Scale Biomolecular Simulations Biophysical Journal. 98: 698a. DOI: 10.1016/J.Bpj.2009.12.3833  0.452
2009 Shimomura K, Flanagan SE, Zadek B, Lethby M, Zubcevic L, Girard CA, Petz O, Mannikko R, Kapoor RR, Hussain K, Skae M, Clayton P, Hattersley A, Ellard S, Ashcroft FM. Adjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism. Embo Molecular Medicine. 1: 166-77. PMID 20049716 DOI: 10.1002/Emmm.200900018  0.817
2009 Hoppa MB, Collins S, Ramracheya R, Hodson L, Amisten S, Zhang Q, Johnson P, Ashcroft FM, Rorsman P. Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules. Cell Metabolism. 10: 455-65. PMID 19945403 DOI: 10.1016/J.Cmet.2009.09.011  0.354
2009 Stansfeld PJ, Hopkinson R, Ashcroft FM, Sansom MS. PIP(2)-binding site in Kir channels: definition by multiscale biomolecular simulations. Biochemistry. 48: 10926-33. PMID 19839652 DOI: 10.1021/Bi9013193  0.439
2009 Shimomura K, Galvanovskis J, Goldsworthy M, Hugill A, Kaizak S, Lee A, Meadows N, Quwailid MM, Rydström J, Teboul L, Ashcroft F, Cox RD. Insulin secretion from beta-cells is affected by deletion of nicotinamide nucleotide transhydrogenase. Methods in Enzymology. 457: 451-80. PMID 19426883 DOI: 10.1016/S0076-6879(09)05025-3  0.357
2009 Ashcroft FM, Zubcevic L. Retraction for Ma et al. "Glucose regulates the effects of leptin on hypothalamic POMC neurons". Proceedings of the National Academy of Sciences of the United States of America. 106: 7263. PMID 19380749 DOI: 10.1073/Pnas.0902342106  0.71
2009 Craig TJ, Shimomura K, Holl RW, Flanagan SE, Ellard S, Ashcroft FM. An in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1. The Journal of Clinical Endocrinology and Metabolism. 94: 2551-7. PMID 19351728 DOI: 10.1210/Mend.23.6.9997  0.455
2009 Tammaro P, Ashcroft FM. A cytosolic factor that inhibits KATP channels expressed in Xenopus oocytes by impairing Mg-nucleotide activation by SUR1. The Journal of Physiology. 587: 1649-56. PMID 19237428 DOI: 10.1113/Jphysiol.2008.165126  0.551
2009 Girard CA, Wunderlich FT, Shimomura K, Collins S, Kaizik S, Proks P, Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Clark R, Church C, Hugill A, Galvanovskis J, ... ... Ashcroft FM, et al. Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. The Journal of Clinical Investigation. 119: 80-90. PMID 19065048 DOI: 10.1172/Jci35772  0.784
2009 Aittoniemi J, Fotinou C, Craig TJ, de Wet H, Proks P, Ashcroft FM. Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 364: 257-67. PMID 18990670 DOI: 10.1098/Rstb.2008.0142  0.5
2009 Proks P, Ashcroft FM. Modeling K(ATP) channel gating and its regulation. Progress in Biophysics and Molecular Biology. 99: 7-19. PMID 18983870 DOI: 10.1016/J.Pbiomolbio.2008.10.002  0.57
2009 Ashcroft F, Gadsby D, Miller C. Introduction. The blurred boundary between channels and transporters: We dedicate this volume to the memory of Peter Läuger, a pioneer of the link between channels and pumps Philosophical Transactions of the Royal Society B: Biological Sciences. 364: 145-147. PMID 18957372 DOI: 10.1098/Rstb.2008.0245  0.367
2009 Hoppa MB, Collins S, Ramracheya R, Johnson P, Ashcroft FM, Rorsman P. Chronic Palmitate Exposure Inhibits Insulin Secretion By Dissociation of Ca2+-Channels From Secretory Vesicles Biophysical Journal. 96: 103a. DOI: 10.1016/J.Bpj.2008.12.442  0.351
2008 Zehetner J, Danzer C, Collins S, Eckhardt K, Gerber PA, Ballschmieter P, Galvanovskis J, Shimomura K, Ashcroft FM, Thorens B, Rorsman P, Krek W. PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. Genes & Development. 22: 3135-46. PMID 19056893 DOI: 10.1101/Gad.496908  0.351
2008 Ma X, Zubcevic L, Ashcroft FM. Glucose regulates the effects of leptin on hypothalamic POMC neurons. Proceedings of the National Academy of Sciences of the United States of America. 105: 9811-6. PMID 18599453 DOI: 10.1073/Pnas.0800952105  0.729
2008 Craig TJ, Ashcroft FM, Proks P. How ATP inhibits the open K(ATP) channel. The Journal of General Physiology. 132: 131-44. PMID 18591420 DOI: 10.1085/Jgp.200709874  0.517
2008 Staník J, Lethby M, Flanagan SE, Gasperíková D, Milosovicová B, Lever M, Bullman H, Zubcevic L, Hattersley AT, Ellard S, Ashcroft FM, Klimes I. Coincidence of a novel KCNJ11 missense variant R365H with a paternally inherited 6q24 duplication in a patient with transient neonatal diabetes. Diabetes Care. 31: 1736-7. PMID 18556340 DOI: 10.2337/Dc08-0549  0.726
2008 D'Amato E, Tammaro P, Craig TJ, Tosi A, Giorgetti R, Lorini R, Ashcroft FM. Variable phenotypic spectrum of diabetes mellitus in a family carrying a novel KCNJ11 gene mutation. Diabetic Medicine : a Journal of the British Diabetic Association. 25: 651-6. PMID 18544102 DOI: 10.1111/J.1464-5491.2008.02443.X  0.438
2008 de Wet H, Proks P, Lafond M, Aittoniemi J, Sansom MS, Flanagan SE, Pearson ER, Hattersley AT, Ashcroft FM. A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes. Embo Reports. 9: 648-54. PMID 18497752 DOI: 10.1038/Embor.2008.71  0.521
2008 Goldsworthy M, Hugill A, Freeman H, Horner E, Shimomura K, Bogani D, Pieles G, Mijat V, Arkell R, Bhattacharya S, Ashcroft FM, Cox RD. Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes. 57: 2234-44. PMID 18477811 DOI: 10.2337/Db07-0337  0.411
2008 Tammaro P, Flanagan SE, Zadek B, Srinivasan S, Woodhead H, Hameed S, Klimes I, Hattersley AT, Ellard S, Ashcroft FM. A Kir6.2 mutation causing severe functional effects in vitro produces neonatal diabetes without the expected neurological complications. Diabetologia. 51: 802-10. PMID 18335204 DOI: 10.1007/S00125-008-0923-1  0.513
2008 Shield JP, Flanagan SE, Mackay DJ, Harries LW, Proks P, Girard C, Ashcroft FM, Temple IK, Ellard S. Mosaic paternal uniparental isodisomy and an ABCC8 gene mutation in a patient with permanent neonatal diabetes and hemihypertrophy. Diabetes. 57: 255-8. PMID 17942821 DOI: 10.2337/Db07-0999  0.34
2008 Tricarico D, Mele A, Liss B, Ashcroft FM, Lundquist AL, Desai RR, George AL, Conte Camerino D. Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats. Neuromuscular Disorders : Nmd. 18: 74-80. PMID 17825556 DOI: 10.1016/J.Nmd.2007.07.009  0.465
2007 de Wet H, Rees MG, Shimomura K, Aittoniemi J, Patch AM, Flanagan SE, Ellard S, Hattersley AT, Sansom MS, Ashcroft FM. Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes. Proceedings of the National Academy of Sciences of the United States of America. 104: 18988-92. PMID 18025464 DOI: 10.1073/Pnas.0707428104  0.536
2007 Mlynarski W, Tarasov AI, Gach A, Girard CA, Pietrzak I, Zubcevic L, Kusmierek J, Klupa T, Malecki MT, Ashcroft FM. Sulfonylurea improves CNS function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11. Nature Clinical Practice. Neurology. 3: 640-5. PMID 17982434 DOI: 10.1038/Ncpneuro0640  0.792
2007 Jarosławski S, Zadek B, Ashcroft F, Vénien-Bryan C, Scheuring S. Direct Visualization of KirBac3.1 Potassium Channel Gating by Atomic Force Microscopy Journal of Molecular Biology. 374: 500-505. PMID 17936299 DOI: 10.1016/J.Jmb.2007.09.043  0.466
2007 Tarasov AI, Girard CA, Larkin B, Tammaro P, Flanagan SE, Ellard S, Ashcroft FM. Functional analysis of two Kir6.2 (KCNJ11) mutations, K170T and E322K, causing neonatal diabetes. Diabetes, Obesity & Metabolism. 9: 46-55. PMID 17919178 DOI: 10.1111/J.1463-1326.2007.00777.X  0.543
2007 Tammaro P, Ashcroft FM. A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit. The Journal of Physiology. 584: 743-53. PMID 17855752 DOI: 10.1113/Jphysiol.2007.143149  0.543
2007 Haider S, Tarasov AI, Craig TJ, Sansom MS, Ashcroft FM. Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis. The Embo Journal. 26: 3749-59. PMID 17673911 DOI: 10.1038/Sj.Emboj.7601809  0.511
2007 Ellard S, Flanagan SE, Girard CA, Patch AM, Harries LW, Parrish A, Edghill EL, Mackay DJ, Proks P, Shimomura K, Haberland H, Carson DJ, Shield JP, Hattersley AT, Ashcroft FM. Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects. American Journal of Human Genetics. 81: 375-82. PMID 17668386 DOI: 10.1086/519174  0.394
2007 Shimomura K, Hörster F, de Wet H, Flanagan SE, Ellard S, Hattersley AT, Wolf NI, Ashcroft F, Ebinger F. A novel mutation causing DEND syndrome: a treatable channelopathy of pancreas and brain. Neurology. 69: 1342-9. PMID 17652641 DOI: 10.1212/01.Wnl.0000268488.51776.53  0.462
2007 Ashcroft FM. The Walter B. Cannon Physiology in Perspective Lecture, 2007. ATP-sensitive K+ channels and disease: from molecule to malady. American Journal of Physiology. Endocrinology and Metabolism. 293: E880-9. PMID 17652156 DOI: 10.1152/Ajpendo.00348.2007  0.561
2007 Ma X, Bruning J, Ashcroft FM. Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7125-9. PMID 17611265 DOI: 10.1523/Jneurosci.1025-07.2007  0.347
2007 Proks P, Shimomura K, Craig TJ, Girard CA, Ashcroft FM. Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome. Human Molecular Genetics. 16: 2011-9. PMID 17584766 DOI: 10.1093/Hmg/Ddm149  0.523
2007 Könner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, Brüning JC. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metabolism. 5: 438-49. PMID 17550779 DOI: 10.1016/J.Cmet.2007.05.004  0.325
2007 Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. Plos Genetics. 3: e64. PMID 17465682 DOI: 10.1371/Journal.Pgen.0030064  0.304
2007 Olofsson CS, Collins S, Bengtsson M, Eliasson L, Salehi A, Shimomura K, Tarasov A, Holm C, Ashcroft F, Rorsman P. Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane. Diabetes. 56: 1888-97. PMID 17456851 DOI: 10.2337/Db06-1150  0.38
2007 Tammaro P, Ashcroft F. The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits Journal of Physiology. 581: 1259-1269. PMID 17395632 DOI: 10.1113/Jphysiol.2007.130211  0.523
2007 Zhang Q, Bengtsson M, Partridge C, Salehi A, Braun M, Cox R, Eliasson L, Johnson PR, Renström E, Schneider T, Berggren PO, Göpel S, Ashcroft FM, Rorsman P. R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion. Nature Cell Biology. 9: 453-60. PMID 17369816 DOI: 10.1038/Ncb1563  0.515
2007 Haider S, Khalid S, Tucker SJ, Ashcroft FM, Sansom MS. Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study. Biochemistry. 46: 3643-52. PMID 17326663 DOI: 10.1021/Bi062210F  0.614
2007 Ma X, Zubcevic L, Brüning JC, Ashcroft FM, Burdakov D. Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1529-33. PMID 17301161 DOI: 10.1523/Jneurosci.3583-06.2007  0.764
2006 Tammaro P, Ashcroft FM. Keeping the heart going: a new role for KATP channels. The Journal of Physiology. 577: 767. PMID 17068097 DOI: 10.1113/Jphysiol.2006.123018  0.451
2006 Tarasov AI, Welters HJ, Senkel S, Ryffel GU, Hattersley AT, Morgan NG, Ashcroft FM. A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells. Diabetes. 55: 3075-82. PMID 17065345 DOI: 10.2337/Db06-0637  0.562
2006 Freeman H, Shimomura K, Cox RD, Ashcroft FM. Nicotinamide nucleotide transhydrogenase: a link between insulin secretion, glucose metabolism and oxidative stress. Biochemical Society Transactions. 34: 806-10. PMID 17052203 DOI: 10.1042/Bst0340806  0.443
2006 Girard CA, Shimomura K, Proks P, Absalom N, Castano L, Perez de Nanclares G, Ashcroft FM. Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes. Pflã¼Gers Archiv : European Journal of Physiology. 453: 323-32. PMID 17021801 DOI: 10.1007/S00424-006-0112-3  0.568
2006 Tarasov AI, Girard CA, Ashcroft FM. ATP sensitivity of the ATP-sensitive K+ channel in intact and permeabilized pancreatic beta-cells. Diabetes. 55: 2446-54. PMID 16936192 DOI: 10.2337/Db06-0360  0.561
2006 Pearson ER, Flechtner I, Njølstad PR, Malecki MT, Flanagan SE, Larkin B, Ashcroft FM, Klimes I, Codner E, Iotova V, Slingerland AS, Shield J, Robert JJ, Holst JJ, Clark PM, et al. Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. The New England Journal of Medicine. 355: 467-77. PMID 16885550 DOI: 10.1056/Nejmoa061759  0.497
2006 Freeman HC, Hugill A, Dear NT, Ashcroft FM, Cox RD. Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice. Diabetes. 55: 2153-6. PMID 16804088 DOI: 10.2337/Db06-0358  0.318
2006 Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, ... ... Ashcroft FM, et al. Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. The Journal of Clinical Investigation. 116: 1886-901. PMID 16794735 DOI: 10.1172/Jci27123  0.656
2006 Proks P, Girard C, Baevre H, Njølstad PR, Ashcroft FM. Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy. Diabetes. 55: 1731-7. PMID 16731836 DOI: 10.2337/Db05-1420  0.549
2006 Shimomura K, Girard CA, Proks P, Nazim J, Lippiat JD, Cerutti F, Lorini R, Ellard S, Hattersley AT, Barbetti F, Ashcroft FM. Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects. Diabetes. 55: 1705-12. PMID 16731833 DOI: 10.2337/Db05-1640  0.537
2006 Proks P, Arnold AL, Bruining J, Girard C, Flanagan SE, Larkin B, Colclough K, Hattersley AT, Ashcroft FM, Ellard S. A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes. Human Molecular Genetics. 15: 1793-800. PMID 16613899 DOI: 10.1093/Hmg/Ddl101  0.497
2006 Ashcroft FM. K(ATP) channels and insulin secretion: a key role in health and disease. Biochemical Society Transactions. 34: 243-6. PMID 16545085 DOI: 10.1042/Bst20060243  0.571
2006 Deacon RM, Brook RC, Meyer D, Haeckel O, Ashcroft FM, Miki T, Seino S, Liss B. Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2. Physiology & Behavior. 87: 723-33. PMID 16530794 DOI: 10.1016/J.Physbeh.2006.01.013  0.475
2006 Freeman H, Shimomura K, Horner E, Cox RD, Ashcroft FM. Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion. Cell Metabolism. 3: 35-45. PMID 16399503 DOI: 10.1016/J.Cmet.2005.10.008  0.382
2006 Tammaro P, Proks P, Ashcroft FM. Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels. The Journal of Physiology. 571: 3-14. PMID 16339180 DOI: 10.1113/Jphysiol.2005.099168  0.563
2005 Mikhailov MV, Campbell JD, de Wet H, Shimomura K, Zadek B, Collins RF, Sansom MS, Ford RC, Ashcroft FM. 3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1. The Embo Journal. 24: 4166-75. PMID 16308567 DOI: 10.1038/Sj.Emboj.7600877  0.503
2005 Hattersley AT, Ashcroft FM. Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy. Diabetes. 54: 2503-13. PMID 16123337 DOI: 10.2337/Diabetes.54.9.2503  0.538
2005 Proks P, Girard C, Ashcroft FM. Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP. Human Molecular Genetics. 14: 2717-26. PMID 16087682 DOI: 10.1093/Hmg/Ddi305  0.571
2005 Ashcroft FM. ATP-sensitive potassium channelopathies: focus on insulin secretion. The Journal of Clinical Investigation. 115: 2047-58. PMID 16075046 DOI: 10.1172/Jci25495  0.554
2005 Tammaro P, Girard C, Molnes J, Njølstad PR, Ashcroft FM. Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions. The Embo Journal. 24: 2318-30. PMID 15962003 DOI: 10.1038/Sj.Emboj.7600715  0.539
2005 Haider S, Antcliff JF, Proks P, Sansom MS, Ashcroft FM. Focus on Kir6.2: a key component of the ATP-sensitive potassium channel. Journal of Molecular and Cellular Cardiology. 38: 927-36. PMID 15910877 DOI: 10.1016/J.Yjmcc.2005.01.007  0.573
2005 Proks P, Girard C, Haider S, Gloyn AL, Hattersley AT, Sansom MS, Ashcroft FM. A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome. Embo Reports. 6: 470-5. PMID 15864298 DOI: 10.1038/Sj.Embor.7400393  0.542
2005 Haider S, Grottesi A, Hall BA, Ashcroft FM, Sansom MS. Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating. Biophysical Journal. 88: 3310-20. PMID 15749783 DOI: 10.1529/Biophysj.104.052019  0.436
2005 Toye AA, Lippiat JD, Proks P, Shimomura K, Bentley L, Hugill A, Mijat V, Goldsworthy M, Moir L, Haynes A, Quarterman J, Freeman HC, Ashcroft FM, Cox RD. A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. Diabetologia. 48: 675-86. PMID 15729571 DOI: 10.1007/S00125-005-1680-Z  0.366
2005 Gloyn AL, Reimann F, Girard C, Edghill EL, Proks P, Pearson ER, Temple IK, Mackay DJ, Shield JP, Freedenberg D, Noyes K, Ellard S, Ashcroft FM, Gribble FM, Hattersley AT. Relapsing diabetes can result from moderately activating mutations in KCNJ11. Human Molecular Genetics. 14: 925-34. PMID 15718250 DOI: 10.1093/Hmg/Ddi086  0.582
2005 Hansen AM, Hansen JB, Carr RD, Ashcroft FM, Wahl P. Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels. British Journal of Pharmacology. 144: 551-7. PMID 15678092 DOI: 10.1038/Sj.Bjp.0706082  0.505
2005 Antcliff JF, Haider S, Proks P, Sansom MS, Ashcroft FM. Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit. The Embo Journal. 24: 229-39. PMID 15650751 DOI: 10.1038/Sj.Emboj.7600487  0.502
2004 Burdakov D, Alexopoulos H, Vincent A, Ashcroft FM. Low-voltage-activated A-current controls the firing dynamics of mouse hypothalamic orexin neurons. The European Journal of Neuroscience. 20: 3281-5. PMID 15610160 DOI: 10.1111/J.1460-9568.2004.03815.X  0.619
2004 Proks P, Antcliff JF, Lippiat J, Gloyn AL, Hattersley AT, Ashcroft FM. Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features. Proceedings of the National Academy of Sciences of the United States of America. 101: 17539-44. PMID 15583126 DOI: 10.1073/Pnas.0404756101  0.561
2004 Campbell JD, Proks P, Lippiat JD, Sansom MS, Ashcroft FM. Identification of a functionally important negatively charged residue within the second catalytic site of the SUR1 nucleotide-binding domains. Diabetes. 53: S123-7. PMID 15561899 DOI: 10.2337/Diabetes.53.Suppl_3.S123  0.511
2004 Yang SB, Proks P, Ashcroft FM, Rupnik M. Inhibition of ATP-sensitive potassium channels by haloperidol. British Journal of Pharmacology. 143: 960-7. PMID 15533888 DOI: 10.1038/Sj.Bjp.0706017  0.554
2004 Campbell JD, Deol SS, Ashcroft FM, Kerr ID, Sansom MS. Nucleotide-dependent conformational changes in HisP: molecular dynamics simulations of an ABC transporter nucleotide-binding domain. Biophysical Journal. 87: 3703-15. PMID 15377525 DOI: 10.1529/Biophysj.104.046870  0.309
2004 Gloyn AL, Pearson ER, Antcliff JF, Proks P, Bruining GJ, Slingerland AS, Howard N, Srinivasan S, Silva JM, Molnes J, Edghill EL, Frayling TM, Temple IK, Mackay D, Shield JP, ... ... Ashcroft FM, et al. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. The New England Journal of Medicine. 350: 1838-49. PMID 15115830 DOI: 10.1056/Nejmoa032922  0.466
2004 Ashcroft FM, Rorsman P. Molecular defects in insulin secretion in type-2 diabetes. Reviews in Endocrine & Metabolic Disorders. 5: 135-42. PMID 15041789 DOI: 10.1023/B:Remd.0000021435.87776.A7  0.307
2004 Park EJ, Bae JH, Kim SY, Lim JG, Baek WK, Kwon TK, Suh SI, Park JW, Lee IK, Ashcroft FM, Song DK. Inhibition of ATP-sensitive K+ channels by taurine through a benzamido-binding site on sulfonylurea receptor 1. Biochemical Pharmacology. 67: 1089-96. PMID 15006545 DOI: 10.1016/J.Bcp.2003.11.003  0.568
2004 Dabrowski M, Tarasov A, Ashcroft FM. Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2. The Journal of Physiology. 557: 347-54. PMID 15004210 DOI: 10.1113/Jphysiol.2003.059105  0.464
2004 Ashcroft F, Rorsman P. Type 2 diabetes mellitus: not quite exciting enough? Human Molecular Genetics. 13: R21-31. PMID 14734629 DOI: 10.1093/Hmg/Ddh066  0.311
2004 Tsuboi T, Lippiat JD, Ashcroft FM, Rutter GA. ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer. Proceedings of the National Academy of Sciences of the United States of America. 101: 76-81. PMID 14681552 DOI: 10.1073/Pnas.0306347101  0.54
2003 Campbell JD, Sansom MSP, Ashcroft FM. Potassium channel regulation. Structural insights into the function of the nucleotide-binding domains of the human sulphonylurea receptor Embo Reports. 4: 1038-1042. PMID 14593442 DOI: 10.1038/Sj.Embor.7400003  0.427
2003 Dabrowski M, Larsen T, Ashcroft FM, Bondo Hansen J, Wahl P. Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues. Diabetologia. 46: 1375-82. PMID 12961066 DOI: 10.1007/S00125-003-1198-1  0.541
2003 Burdakov D, Liss B, Ashcroft FM. Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4951-7. PMID 12832517 DOI: 10.1523/Jneurosci.23-12-04951.2003  0.611
2003 Trapp S, Haider S, Jones P, Sansom MSP, Ashcroft FM. Identification of residues contributing to the ATP binding site of Kir6.2 Embo Journal. 22: 2903-2912. PMID 12805206 DOI: 10.1093/Emboj/Cdg282  0.497
2003 Dabrowski M, Trapp S, Ashcroft FM. Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes. The Journal of Physiology. 550: 357-63. PMID 12766240 DOI: 10.1113/Jphysiol.2003.041715  0.532
2003 Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA. Crystal structure of the potassium channel KirBac1.1 in the closed state. Science (New York, N.Y.). 300: 1922-6. PMID 12738871 DOI: 10.1126/Science.1085028  0.45
2003 Capener CE, Proks P, Ashcroft FM, Sansom MSP. Filter flexibility in a mammalian K channel: Models and simulations of Kir6.2 mutants Biophysical Journal. 84: 2345-2356. PMID 12668443 DOI: 10.1016/S0006-3495(03)75040-1  0.404
2003 Reimann F, Huopio H, Dabrowski M, Proks P, Gribble FM, Laakso M, Otonkoski T, Ashcroft FM. Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population. Diabetologia. 46: 241-9. PMID 12627323 DOI: 10.1007/S00125-002-1014-3  0.687
2003 Reimann F, Dabrowski M, Jones P, Gribble FM, Ashcroft FM. Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides. The Journal of Physiology. 547: 159-68. PMID 12562963 DOI: 10.1113/jphysiol.2002.031625  0.677
2003 Huopio H, Otonkoski T, Vauhkonen I, Reimann F, Ashcroft FM, Laakso M. A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1. Lancet (London, England). 361: 301-7. PMID 12559865 DOI: 10.1016/S0140-6736(03)12325-2  0.399
2003 Proks P, Antcliff JF, Ashcroft FM. The ligand-sensitive gate of a potassium channel lies close to the selectivity filter Embo Reports. 4: 70-75. PMID 12524524 DOI: 10.1038/Sj.Embor.Embor708  0.477
2003 Reimann F, Dabrowski M, Jones P, Gribble FM, Ashcroft FM. Analysis of the differential modulation of sulphonylurea block of β‐cell and cardiac ATP‐sensitive K+ (KATP) channels by Mg‐nucleotides The Journal of Physiology. 547: 159-168. DOI: 10.1111/J.1469-7793.2003.00159.X  0.688
2002 Proks P, Reimann F, Green N, Gribble F, Ashcroft F. Sulfonylurea stimulation of insulin secretion. Diabetes. 51: S368-76. PMID 12475777 DOI: 10.2337/Diabetes.51.2007.S368  0.703
2002 Burdakov D, Ashcroft FM. Shedding new light on brain metabolism and glial function. The Journal of Physiology. 544: 334. PMID 12381806 DOI: 10.1113/Jphysiol.2002.029090  0.661
2002 Hansen AMK, Christensen IT, Hansen JB, Carr RD, Ashcroft FM, Wahl P. Differential interactions of nateglinide and repaglinide on the human β-cell sulphonylurea receptor 1 Diabetes. 51: 2789-2795. PMID 12196472 DOI: 10.2337/Diabetes.51.9.2789  0.474
2002 Gros L, Trapp S, Dabrowski M, Ashcroft FM, Bataille D, Blache P. Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31. British Journal of Pharmacology. 137: 98-106. PMID 12183335 DOI: 10.1038/Sj.Bjp.0704836  0.527
2002 Matsuo M, Dabrowski M, Ueda K, Ashcroft FM. Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding. The Embo Journal. 21: 4250-8. PMID 12169627 DOI: 10.1093/Emboj/Cdf419  0.495
2002 Burdakov D, Ashcroft FM. Cholecystokinin tunes firing of an electrically distinct subset of arcuate nucleus neurons by activating A-Type potassium channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6380-7. PMID 12151516 DOI: 10.1523/Jneurosci.22-15-06380.2002  0.636
2002 Dabrowski M, Ashcroft FM, Ashfield R, Lebrun P, Pirotte B, Egebjerg J, Bondo Hansen J, Wahl P. The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener. Diabetes. 51: 1896-906. PMID 12031979 DOI: 10.2337/Diabetes.51.6.1896  0.539
2001 Jones PA, Tucker SJ, Ashcroft FM. Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2. Febs Letters. 508: 85-9. PMID 11707273 DOI: 10.1016/S0014-5793(01)03023-X  0.612
2001 Proks P, Capener CE, Jones P, Ashcroft FM. Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel Journal of General Physiology. 118: 341-353. PMID 11585848 DOI: 10.1085/Jgp.118.4.341  0.531
2001 Reimann F, Ashcroft FM, Gribble FM. Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes. 50: 2253-9. PMID 11574406 DOI: 10.2337/Diabetes.50.10.2253  0.699
2001 Lawrence CL, Proks P, Rodrigo GC, Jones P, Hayabuchi Y, Standen NB, Ashcroft FM. Gliclazide produces high-affinity block of KATP, channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells Diabetologia. 44: 1019-1025. PMID 11484080 DOI: 10.1007/S001250100595  0.445
2001 Dabrowski M, Wahl P, Holmes WE, Ashcroft FM. Effect of repaglinide on cloned beta cell, cardiac and smooth muscle types of ATP-sensitive potassium channels. Diabetologia. 44: 747-56. PMID 11440368 DOI: 10.1007/S001250051684  0.525
2001 Loussouarn G, Pike LJ, Ashcroft FM, Makhina EN, Nichols CG. Dynamic sensitivity of ATP-sensitive K(+) channels to ATP. The Journal of Biological Chemistry. 276: 29098-103. PMID 11395495 DOI: 10.1074/Jbc.M102365200  0.536
2001 Song DK, Ashcroft FM. Glimepiride block of cloned β-cell, cardiac and smooth muscle K ATP channels British Journal of Pharmacology. 133: 193-199. PMID 11325810 DOI: 10.1038/Sj.Bjp.0704062  0.52
2001 Miki T, Liss B, Minami K, Shiuchi T, Saraya A, Kashima Y, Horiuchi M, Ashcroft F, Minokoshi Y, Roeper J, Seino S. ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nature Neuroscience. 4: 507-12. PMID 11319559 DOI: 10.1038/87455  0.723
2001 Reimann F, Proks P, Ashcroft FM. Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel. British Journal of Pharmacology. 132: 1542-8. PMID 11264248 DOI: 10.1038/Sj.Bjp.0703962  0.539
2001 Proks P, Jones P, Ashcroft FM. Interaction of stilbene disulphonates with cloned K ATP channels British Journal of Pharmacology. 132: 973-982. PMID 11226127 DOI: 10.1038/Sj.Bjp.0703916  0.538
2001 Song DK, Ashcroft FM. ATP Modulation of ATP-sensitive Potassium Channel ATP Sensitivity Varies with the Type of SUR Subunit Journal of Biological Chemistry. 276: 7143-7149. PMID 11115512 DOI: 10.1074/Jbc.M009959200  0.541
2001 Gribble FM, Ashcroft FM. Differentsirovannaya chuvstvitel'nost' ?-kletochnykh i ekstrapankreaticheskikh ATF zavisimykh K kanalov k gliklazidu Diabetes Mellitus. 4: 13-15. DOI: 10.14341/2072-0351-6101  0.489
2000 Ashcroft FM, Gribble FM. New windows on the mechanism of action of K(ATP) channel openers. Trends in Pharmacological Sciences. 21: 439-45. PMID 11121575 DOI: 10.1016/S0165-6147(00)01563-7  0.679
2000 Reimann F, Gribble FM, Ashcroft FM. Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil. Molecular Pharmacology. 58: 1318-25. PMID 11093769 DOI: 10.1124/Mol.58.6.1318  0.691
2000 Gribble FM, Ashcroft FM. Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels from beta cells and extrapancreatic tissues. Metabolism: Clinical and Experimental. 49: 3-6. PMID 11078468  0.676
2000 Gribble FM, Davis TM, Higham CE, Clark A, Ashcroft FM. The antimalarial agent mefloquine inhibits ATP-sensitive K-channels. British Journal of Pharmacology. 131: 756-60. PMID 11030725 DOI: 10.1038/Sj.Bjp.0703638  0.699
2000 Huopio H, Reimann F, Ashfield R, Komulainen J, Lenko HL, Rahier J, Vauhkonen I, Kere J, Laakso M, Ashcroft F, Otonkoski T. Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1. The Journal of Clinical Investigation. 106: 897-906. PMID 11018078 DOI: 10.1172/Jci9804  0.491
2000 Ashcroft FM, Gribble FM. Tissue-specific effects of sulfonylureas: lessons from studies of cloned K(ATP) channels. Journal of Diabetes and Its Complications. 14: 192-6. PMID 11004427 DOI: 10.1016/S1056-8727(00)00081-7  0.7
2000 Matsuo M, Trapp S, Tanizawa Y, Kioka N, Amachi T, Oka Y, Ashcroft FM, Ueda K. Functional analysis of a mutant sulfonylurea receptor, SUR1-R1420C, that is responsible for persistent hyperinsulinemic hypoglycemia of infancy Journal of Biological Chemistry. 275: 41184-41191. PMID 10993895 DOI: 10.1074/Jbc.M006503200  0.561
2000 Gribble FM, Loussouarn G, Tucker SJ, Zhao C, Nichols CG, Ashcroft FM. A novel method for measurement of submembrane ATP concentration. The Journal of Biological Chemistry. 275: 30046-9. PMID 10866996 DOI: 10.1074/Jbc.M001010200  0.713
2000 Tanabe K, Tucker SJ, Ashcroft FM, Proks P, Kioka N, Amachi T, Ueda K. Direct photoaffinity labeling of Kir6.2 by [gamma-(32)P]ATP-[gamma]4-azidoanilide. Biochemical and Biophysical Research Communications. 272: 316-9. PMID 10833411 DOI: 10.1006/Bbrc.2000.2780  0.64
2000 Gribble FM, Reimann F, Ashfield R, Ashcroft FM. Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A. Molecular Pharmacology. 57: 1256-61. PMID 10825398  0.647
2000 Gribble FM, Ashcroft FM. Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels fromcells and extrapancreatic tissues Metabolism-Clinical and Experimental. 49: 3-6. DOI: 10.1053/Meta.2000.17822  0.705
1999 Smith PA, Proks P, Ashcroft FM. Quantal analysis of 5-hydroxytryptamine release from mouse pancreatic beta-cells. The Journal of Physiology. 521: 651-64. PMID 10601496 DOI: 10.1111/J.1469-7793.1999.00651.X  0.428
1999 Sakura H, Trapp S, Liss B, Ashcroft FM. Altered functional properties of K(ATP) channel conferred by a novel splice variant of SUR1 Journal of Physiology. 521: 337-350. PMID 10581306 DOI: 10.1111/J.1469-7793.1999.00337.X  0.559
1999 Matsuo M, Tucker SJ, Ashcroft FM, Amachi T, Ueda K. NEM modification prevents high-affinity ATP binding to the first nucleotide binding fold of the sulphonylurea receptor, SUR1. Febs Letters. 458: 292-4. PMID 10570926 DOI: 10.1016/S0014-5793(99)01170-9  0.627
1999 Tucker SJ, Ashcroft FM. Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2. The Journal of Biological Chemistry. 274: 33393-7. PMID 10559219 DOI: 10.1074/Jbc.274.47.33393  0.636
1999 Le Brigand L, Virsolvy A, Manechez D, Godfroid JJ, Guardiola-Lemaître B, Gribble FM, Ashcroft FM, Bataille D. In vitro mechanism of action on insulin release of S-22068, a new putative antidiabetic compound. British Journal of Pharmacology. 128: 1021-6. PMID 10556939 DOI: 10.1038/Sj.Bjp.0702883  0.651
1999 Reimann F, Ryder TJ, Tucker SJ, Ashcroft FM. The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP. The Journal of Physiology. 520: 661-9. PMID 10545134 DOI: 10.1111/J.1469-7793.1999.00661.X  0.697
1999 Ashcroft FM, Gribble FM. ATP-sensitive K+ channels and insulin secretion: their role in health and disease. Diabetologia. 42: 903-19. PMID 10491749 DOI: 10.1007/S001250051247  0.646
1999 Proks P, Ashfield R, Ashcroft FM. Interaction of vanadate with the cloned beta cell K(ATP) channel Journal of Biological Chemistry. 274: 25393-25397. PMID 10464267 DOI: 10.1074/Jbc.274.36.25393  0.564
1999 Reimann F, Ashcroft FM. Inwardly rectifying potassium channels Current Opinion in Cell Biology. 11: 503-508. PMID 10449331 DOI: 10.1016/S0955-0674(99)80073-8  0.516
1999 Gribble FM, Ashcroft FM. Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide. Diabetologia. 42: 845-8. PMID 10440127 DOI: 10.1007/S001250051236  0.677
1999 Reimann F, Tucker SJ, Proks P, Ashcroft FM. Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor. The Journal of Physiology. 518: 325-36. PMID 10381582 DOI: 10.1111/J.1469-7793.1999.0325P.X  0.682
1999 Ashfield R, Gribble FM, Ashcroft SJ, Ashcroft FM. Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel. Diabetes. 48: 1341-7. PMID 10342826 DOI: 10.2337/Diabetes.48.6.1341  0.69
1999 Otonkoski T, Ammälä C, Huopio H, Cote GJ, Chapman J, Cosgrove K, Ashfield R, Huang E, Komulainen J, Ashcroft FM, Dunne MJ, Kere J, Thomas PM. A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland. Diabetes. 48: 408-15. PMID 10334322 DOI: 10.2337/Diabetes.48.2.408  0.456
1999 Dalle S, Smith P, Blache P, Le-Nguyen D, Le Brigand L, Bergeron F, Ashcroft FM, Bataille D. Miniglucagon (glucagon 19-29), a potent and efficient inhibitor of secretagogue-induced insulin release through a Ca2+ pathway. The Journal of Biological Chemistry. 274: 10869-76. PMID 10196164 DOI: 10.1074/Jbc.274.16.10869  0.525
1999 Tanabe K, Tucker SJ, Matsuo M, Proks P, Ashcroft FM, Seino S, Amachi T, Ueda K. Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP. The Journal of Biological Chemistry. 274: 3931-3. PMID 9933580 DOI: 10.1074/Jbc.274.7.3931  0.675
1999 Proks P, Gribble FM, Adhikari R, Tucker SJ, Ashcroft FM. Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP. The Journal of Physiology. 514: 19-25. PMID 9831713 DOI: 10.1111/J.1469-7793.1999.019Af.X  0.751
1998 Ashcroft FM. Exciting times for PIP2 Science. 282: 1059-1060. PMID 9841452 DOI: 10.1126/Science.282.5391.1059  0.459
1998 Gribble FM, Proks P, Corkey BE, Ashcroft FM. Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA. The Journal of Biological Chemistry. 273: 26383-7. PMID 9756869 DOI: 10.1074/Jbc.273.41.26383  0.702
1998 Gribble FM, Tucker SJ, Seino S, Ashcroft FM. Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels. Diabetes. 47: 1412-8. PMID 9726229 DOI: 10.2337/Diabetes.47.9.1412  0.755
1998 Trapp S, Proks P, Tucker SJ, Ashcroft FM. Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP. The Journal of General Physiology. 112: 333-49. PMID 9725893 DOI: 10.1085/Jgp.112.3.333  0.693
1998 Trapp S, Tucker SJ, Ashcroft FM. Mechanism of ATP-sensitive K channel inhibition by sulfhydryl modification. The Journal of General Physiology. 112: 325-32. PMID 9725892 DOI: 10.1085/Jgp.112.3.325  0.699
1998 Tucker SJ, Ashcroft FM. A touching case of channel regulation: the ATP-sensitive K+ channel. Current Opinion in Neurobiology. 8: 316-20. PMID 9687347 DOI: 10.1016/S0959-4388(98)80055-X  0.69
1998 Ashcroft FM, Gribble FM. Correlating structure and function in ATP-sensitive K+ channels. Trends in Neurosciences. 21: 288-94. PMID 9683320 DOI: 10.1016/S0166-2236(98)01225-9  0.683
1998 Mikhailov MV, Proks P, Ashcroft FM, Ashcroft SJH. Expression of functionally active ATP-sensitive K-channels in insect cells using baculovirus Febs Letters. 429: 390-394. PMID 9662455 DOI: 10.1016/S0014-5793(98)00640-1  0.531
1998 Sakura H, Ashcroft SJH, Terauchi Y, Kadowaki T, Ashcroft FM. Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice Diabetologia. 41: 654-659. PMID 9662046 DOI: 10.1007/S001250050964  0.468
1998 Heron L, Virsolvy A, Peyrollier K, Gribble FM, Le Cam A, Ashcroft FM, Bataille D. Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties. Proceedings of the National Academy of Sciences of the United States of America. 95: 8387-91. PMID 9653196 DOI: 10.1073/Pnas.95.14.8387  0.66
1998 Tucker SJ, Gribble FM, Proks P, Trapp S, Ryder TJ, Haug T, Reimann F, Ashcroft FM. Molecular determinants of KATP channel inhibition by ATP. The Embo Journal. 17: 3290-6. PMID 9628866 DOI: 10.1093/Emboj/17.12.3290  0.766
1998 Gribble FM, Tucker SJ, Haug T, Ashcroft FM. MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit. Proceedings of the National Academy of Sciences of the United States of America. 95: 7185-90. PMID 9618560 DOI: 10.1073/Pnas.95.12.7185  0.78
1998 Hughes SJ, Faehling M, Thorneley CW, Proks P, Ashcroft FM, Smith PA. Electrophysiological and metabolic characterization of single beta-cells and islets from diabetic GK rats. Diabetes. 47: 73-81. PMID 9421377 DOI: 10.2337/Diab.47.1.73  0.539
1997 Smith P, Millard PJ, Fewtrell CM, Ashcroft FM. Heterogeneity of beta-cell Ca2+ responses to glucose. Advances in Experimental Medicine and Biology. 426: 253-7. PMID 9544282 DOI: 10.1007/978-1-4899-1819-2_35  0.464
1997 Gribble FM, Tucker SJ, Ashcroft FM. The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation. The Journal of Physiology. 504: 35-45. PMID 9350615 DOI: 10.1111/J.1469-7793.1997.00035.X  0.744
1997 Proks P, Ashcroft FM. Phentolamine block of K(ATP) channels is mediated by Kir6.2 Proceedings of the National Academy of Sciences of the United States of America. 94: 11716-11720. PMID 9326676 DOI: 10.1073/Pnas.94.21.11716  0.578
1997 Trapp S, Tucker SJ, Ashcroft FM. Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits. Proceedings of the National Academy of Sciences of the United States of America. 94: 8872-7. PMID 9238070 DOI: 10.1073/Pnas.94.16.8872  0.719
1997 Tucker SJ, Gribble FM, Zhao C, Trapp S, Ashcroft FM. Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor. Nature. 387: 179-83. PMID 9144288 DOI: 10.1038/387179A0  0.779
1997 Gribble FM, Tucker SJ, Ashcroft FM. The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide. The Embo Journal. 16: 1145-52. PMID 9135131 DOI: 10.1093/Emboj/16.6.1145  0.781
1997 Smith PA, Sakura H, Coles B, Gummerson N, Proks P, Ashcroft FM. Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells. The Journal of Physiology. 499: 625-35. PMID 9130159 DOI: 10.1113/Jphysiol.1997.Sp021955  0.433
1997 Gribble FM, Ashfield R, Ammälä C, Ashcroft FM. Properties of cloned ATP-sensitive K+ currents expressed in Xenopus oocytes. The Journal of Physiology. 498: 87-98. PMID 9023770 DOI: 10.1113/Jphysiol.1997.Sp021843  0.691
1997 Trapp S, Ashcroft FM. A metabolic sensor in action: News from the ATP-sensitive K+-channel News in Physiological Sciences. 12: 255-262. DOI: 10.1152/Physiologyonline.1997.12.6.255  0.51
1997 Smith P, Millard PJ, Fewtrell CMS, Ashcroft FM. Heterogeneity of β-cell Ca2+ responses to glucose Advances in Experimental Medicine and Biology. 426: 253-257.  0.309
1996 Proks P, Eliasson L, Ämmälä C, Rorsman P, Ashcroft FM. Ca2+- and GTP-dependent exocytosis in mouse pancreatic β-cells involves both common and distinct steps Journal of Physiology. 496: 255-264. PMID 8910213 DOI: 10.1113/Jphysiol.1996.Sp021682  0.318
1996 Sakura H, Wat N, Horton V, Millns H, Turner RC, Ashcroft FM. Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro. Diabetologia. 39: 1233-6. PMID 8897013 DOI: 10.1007/Bf02658512  0.478
1996 Eliasson L, Proks P, Ammälä C, Ashcroft FM, Bokvist K, Renström E, Rorsman P, Smith PA. Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium. The Journal of Physiology. 493: 755-67. PMID 8799897 DOI: 10.1113/Jphysiol.1996.Sp021420  0.439
1996 Tucker SJ, Pessia M, Moorhouse AJ, Gribble F, Ashcroft FM, Maylie J, Adelman JP. Heteromeric channel formation and Ca2+-free media reduce the toxic effect of the weaver K(ir), 3.2 allele Febs Letters. 390: 253-257. PMID 8706871 DOI: 10.1016/0014-5793(96)00635-7  0.789
1996 Ammälä C, Moorhouse A, Gribble F, Ashfield R, Proks P, Smith PA, Sakura H, Coles B, Ashcroft SJ, Ashcroft FM. Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels. Nature. 379: 545-8. PMID 8596634 DOI: 10.1038/379545A0  0.744
1995 Sakura H, Ammälä C, Smith PA, Gribble FM, Ashcroft FM. Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle. Febs Letters. 377: 338-44. PMID 8549751 DOI: 10.1016/0014-5793(95)01369-5  0.715
1995 Sakura H, Bond C, Warren-Perry M, Horsley S, Kearney L, Tucker S, Adelman J, Turner R, Ashcroft FM. Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit. Febs Letters. 367: 193-7. PMID 7796919 DOI: 10.1016/0014-5793(95)00498-X  0.765
1995 Zhang Y, Warren-Perry M, Sakura H, Adelman J, Stoffel M, Bell GI, Ashcroft FM, Turner RC. No evidence for mutations in a putative beta-cell ATP-sensitive K+ channel subunit in MODY, NIDDM, or GDM. Diabetes. 44: 597-600. PMID 7729622 DOI: 10.2337/Diab.44.5.597  0.663
1995 Bond CT, Ämmälä C, Ashfield R, Blair TA, Gribble F, Khan RN, Lee K, Proks P, Rowe ICM, Sakura H, Ashford MJ, Adelman JP, Ashcroft FM. Cloning and functional expression of the cDNA encoding an inwardly-rectifying potassium channel expressed in pancreatic β-cells and in the brain Febs Letters. 367: 61-66. PMID 7601286 DOI: 10.1016/0014-5793(95)00497-W  0.763
1995 Yasuda K, Sakura H, Mori Y, Iwamoto K, Shimokawa K, Kadowaki H, Hagura R, Akanuma Y, Adelman JP, Yazaki Y, Ashcroft FM, Kadowaki T. No Evidence for Mutations in a Putative Subunit of the β-Cell ATP-Sensitive Potassium Channel (K-ATP Channel) in Japanese NIDDM Patients Biochemical and Biophysical Research Communications. 211: 1036-1040. PMID 7598690 DOI: 10.1006/Bbrc.1995.1915  0.71
1995 Smith PA, Duchen MR, Ashcroft FM. A fluorimetric and amperometric study of calcium and secretion in isolated mouse pancreatic beta-cells. Pflã¼Gers Archiv : European Journal of Physiology. 430: 808-18. PMID 7478937 DOI: 10.1007/Bf00386180  0.467
1994 Proks P, Takano M, Ashcroft FM. Effects of intracellular pH on ATP‐sensitive K+ channels in mouse pancreatic beta‐cells. The Journal of Physiology. 475: 33-44. PMID 8189391 DOI: 10.1113/Jphysiol.1994.Sp020047  0.531
1994 Smith PA, Williams BA, Ashcroft FM. Block of ATP-sensitive K+ channels in isolated mouse pancreatic beta-cells by 2,3-butanedione monoxime. British Journal of Pharmacology. 112: 143-9. PMID 8032636 DOI: 10.1111/J.1476-5381.1994.Tb13044.X  0.616
1994 Ashcroft FM, Proks P, Smith PA, Ammälä C, Bokvist K, Rorsman P. Stimulus-secretion coupling in pancreatic beta cells. Journal of Cellular Biochemistry. 55: 54-65. PMID 7929618 DOI: 10.1002/Jcb.240550007  0.507
1994 Ashcroft FM, Coles B, Kenna S, Proks P, Röper J, Reid J, Smith PA, Takano M. The KATP and Kv channels are distinct entities: a reply to Edwards and Weston. Cardiovascular Research. 28: 738-40; discussion 7. PMID 7923273 DOI: 10.1093/Cvr/28.6.738  0.563
1993 Duchen MR, Smith PA, Ashcroft FM. Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells. The Biochemical Journal. 294: 35-42. PMID 8363584 DOI: 10.1042/Bj2940035  0.492
1993 Williams BA, Smith PA, Leow K, Shimizu S, Gray DW, Ashcroft FM. Two types of potassium channel regulated by ATP in pancreatic B cells isolated from a type-2 diabetic human. Pflã¼Gers Archiv : European Journal of Physiology. 423: 265-73. PMID 8321630 DOI: 10.1007/Bf00374405  0.638
1993 Ämmälä C, Ashcroft FM, Rorsman P. Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells Nature. 363: 356-358. PMID 7684514 DOI: 10.1038/363356A0  0.359
1991 Kelly RP, Sutton R, Ashcroft FM. Voltage-activated calcium and potassium currents in human pancreatic beta-cells. The Journal of Physiology. 443: 175-92. PMID 1822525 DOI: 10.1113/Jphysiol.1991.Sp018829  0.372
1991 Ashcroft FM, Kerr AJ, Gibson JS, Williams BA. Amantadine and sparteine inhibit ATP‐regulated K‐currents in the insulin‐secreting β‐cell line, HIT‐T15 British Journal of Pharmacology. 104: 579-584. PMID 1797321 DOI: 10.1111/J.1476-5381.1991.Tb12472.X  0.476
1990 Smith PA, Ashcroft FM, Rorsman P. Simultaneous recordings of glucose dependent electrical activity and ATP-regulated K(+)-currents in isolated mouse pancreatic beta-cells. Febs Letters. 261: 187-90. PMID 2407553 DOI: 10.1016/0014-5793(90)80667-8  0.553
1990 Ashcroft FM, Rorsman P. ATP-sensitive K+ channels: a link between B-cell metabolism and insulin secretion. Biochemical Society Transactions. 18: 109-11. PMID 2185070 DOI: 10.1042/Bst0180109  0.495
1990 Roeper J, Hainsworth AH, Ashcroft FM. Tolbutamide reverses membrane hyperpolarisation induced by activation of D2 receptors and GABAB receptors in isolated substantia nigra neurones. Pflã¼Gers Archiv : European Journal of Physiology. 416: 473-5. PMID 2169045 DOI: 10.1007/Bf00370758  0.72
1990 Betsholtz C, Baumann A, Kenna S, Ashcroft FM, Ashcroft SJ, Berggren PO, Grupe A, Pongs O, Rorsman P, Sandblom J. Expression of voltage-gated K+ channels in insulin-producing cells. Analysis by polymerase chain reaction. Febs Letters. 263: 121-6. PMID 1691985 DOI: 10.1016/0014-5793(90)80719-Y  0.452
1990 Ashcroft FM, Kelly RP, Smith PA. Two types of Ca channel in rat pancreatic beta-cells. Pflã¼Gers Archiv : European Journal of Physiology. 415: 504-6. PMID 1690385 DOI: 10.1007/Bf00373633  0.559
1989 Ashcroft FM, Kakei M, Kelly RP. Rubidium and sodium permeability of the ATP-sensitive K+ channel in single rat pancreatic beta-cells. The Journal of Physiology. 408: 413-29. PMID 2674421 DOI: 10.1113/Jphysiol.1989.Sp017467  0.462
1989 Ashcroft FM, Kakei M, Gibson JS, Gray DW, Sutton R. The ATP- and tolbutamide-sensitivity of the ATP-sensitive K-channel from human pancreatic B cells Diabetologia. 32: 591-598. PMID 2673893 DOI: 10.1007/Bf00285333  0.538
1989 Findlay I, Ashcroft FM, Kelly RP, Rorsman P, Petersen OH, Trube G. Calcium currents in insulin-secreting beta-cells. Annals of the New York Academy of Sciences. 560: 403-9. PMID 2545146 DOI: 10.1111/J.1749-6632.1989.Tb24122.X  0.335
1989 Niki I, Kelly RP, Ashcroft SJ, Ashcroft FM. ATP-sensitive K-channels in HIT T15 beta-cells studied by patch-clamp methods, 86Rb efflux and glibenclamide binding. PflüGers Archiv : European Journal of Physiology. 415: 47-55. PMID 2516306 DOI: 10.1007/Bf00373140  0.494
1989 Smith PA, Rorsman P, Ashcroft FM. Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells. Nature. 342: 550-3. PMID 2479839 DOI: 10.1038/342550A0  0.562
1989 Rorsman P, Ashcroft FM, Trube G. Single Ca channel currents in mouse pancreatic B-cells. Pflugers Archiv : European Journal of Physiology. 412: 597-603. PMID 2463514 DOI: 10.1007/Bf00583760  0.476
1988 Ashcroft FM, Ashcroft SJ, Berggren PO, Betzholz C, Rorsman P, Trube G, Welsh M. Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting beta-cell line, HIT T15. Febs Letters. 239: 185-9. PMID 2903072 DOI: 10.1016/0014-5793(88)80913-X  0.523
1987 Ashcroft FM, Kakei M, Kelly RP, Sutton R. ATP-sensitive K+ channels in human isolated pancreatic B-cells. Febs Letters. 215: 9-12. PMID 2436949 DOI: 10.1016/0014-5793(87)80103-5  0.521
1986 Kakei M, Kelly RP, Ashcroft SJ, Ashcroft FM. The ATP-sensitivity of K+ channels in rat pancreatic B-cells is modulated by ADP. Febs Letters. 208: 63-6. PMID 2429869 DOI: 10.1016/0014-5793(86)81533-2  0.525
1983 Ashcroft FM, Stanfield PR. The influence of the permeant ions thallous and potassium on inward rectification in frog skeletal muscle. The Journal of Physiology. 343: 407-28. PMID 6315921 DOI: 10.1113/Jphysiol.1983.Sp014900  0.649
1982 Ashcroft FM, Stanfield PR. Calcium inactivation in skeletal muscle fibres of the stick insect, Carausius morosus. The Journal of Physiology. 330: 349-72. PMID 7175746 DOI: 10.1113/Jphysiol.1982.Sp014345  0.59
1982 Stanfield PR, Ashcroft FM. Calcium currents of frog and insect skeletal muscle fibres measured during voltage clamp. Canadian Journal of Physiology and Pharmacology. 60: 508-12. PMID 6286072 DOI: 10.1139/Y82-070  0.606
1982 Ashcroft FM, Stanfield PR. Calcium and potassium currents in muscle fibres of an insect (Carausius morosus). The Journal of Physiology. 323: 93-115. PMID 6284919 DOI: 10.1113/Jphysiol.1982.Sp014063  0.623
1981 Ashcroft FM, Stanfield PR. Calcium dependence of the inactivation of calcium currents in skeletal muscle fibers of an insect. Science (New York, N.Y.). 213: 224-6. PMID 17782788 DOI: 10.1126/Science.213.4504.224  0.585
1981 Stanfield PR, Ashcroft FM, Plant TD. Gating of a muscle K+ channel and its dependence on the permeating ion species. Nature. 289: 509-11. PMID 6258081 DOI: 10.1038/289509A0  0.654
1979 Ashcroft FM, Standen NB, Stanfield PR. Calcium currents in insect muscle [proceedings]. The Journal of Physiology. 291: 51P-52P. PMID 480245  0.534
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