Raymond Chuen-Chung Chang, PhD - Related publications

Affiliations: 
Anatomy The University of Hong Kong, San Francisco, Hong Kong Island, Hong Kong 
Area:
Neuroscience, neuroimmunology, neurodegeneration, Alzheimer's disease, Parkinson's disease, glaucoma, herbal medicine, depression, neuroinflammation
Website:
http://www.anatomy.hku.hk/staff/RCCChang.html
NOTE: We are testing a new system for identifying relevant work based on semantic analysis that identifies similarities between recently published papers and the current author's publications. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches.
50 most relevant papers in past 60 days:
Year Citation  Score
2020 Sun Y, Huang J, Chen Y, Shang H, Zhang W, Yu J, He L, Xing C, Zhuang C. Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer's disease. Bioorganic Chemistry. 103: 104172. PMID 32890991 DOI: 10.1016/j.bioorg.2020.104172   
2020 Calvo-Rodriguez M, García-Rodríguez C, Villalobos C, Núñez L. Role of Toll Like Receptor 4 in Alzheimer's Disease. Frontiers in Immunology. 11: 1588. PMID 32983082 DOI: 10.3389/fimmu.2020.01588   
2020 Zuo H, Liu X, Li Y, Wang D, Hao Y, Yu C, Xu X, Peng R, Song T. The Mitochondria/Caspase-Dependent Apoptotic Pathway Plays a Role in the Positive Effects of a Power frequency electromagnetic field on Alzheimer's Disease Neuronal Model: Running tittle: The effects & mechanism of PF-MF on an AD neuronal model. Journal of Chemical Neuroanatomy. 101857. PMID 32918997 DOI: 10.1016/j.jchemneu.2020.101857   
2020 Cecarini V, Bonfili L, Gogoi O, Lawrence S, Venanzi FM, Azevedo V, Mancha-Agresti P, Drumond MM, Rossi G, Berardi S, Galosi L, Cuccioloni M, Angeletti M, Suchodolski JS, Pilla R, et al. Neuroprotective effects of p62(SQSTM1)-engineered lactic acid bacteria in Alzheimer's disease: a pre-clinical study. Aging. 12. PMID 32855357 DOI: 10.18632/aging.103900   
2020 Li KY, Xiang XJ, Song L, Chen J, Luo B, Wen QX, Zhong BR, Zhou GF, Deng XJ, Ma YL, Hu LT, Chen GJ. Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression. Journal of Neurochemistry. PMID 32920833 DOI: 10.1111/jnc.15184   
2020 Chen WT, Kuo YY, Lin GB, Lu CH, Hsu HP, Sun YK, Chao CY. Thermal cycling protects SH-SY5Y cells against hydrogen peroxide and β-amyloid-induced cell injury through stress response mechanisms involving Akt pathway. Plos One. 15: e0240022. PMID 33002038 DOI: 10.1371/journal.pone.0240022   
2020 von Saucken VE, Jay TR, Landreth GE. The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease. Neurobiology of Disease. 105072. PMID 32890775 DOI: 10.1016/j.nbd.2020.105072   
2020 Tagai N, Tanaka A, Sato A, Uchiumi F, Tanuma SI. Low Levels of Brain-Derived Neurotrophic Factor Trigger Self-aggregated Amyloid β-Induced Neuronal Cell Death in an Alzheimer's Cell Model. Biological & Pharmaceutical Bulletin. 43: 1073-1080. PMID 32612070 DOI: 10.1248/bpb.b20-00082   
2020 Krishnan S, Shrestha Y, Jayatunga DPW, Rea S, Martins R, Bharadwaj P. Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32937909 DOI: 10.3390/ijms21186739   
2020 Qu X, Guan P, Han L, Wang Z, Huang X. Levistolide A Attenuates Alzheimer's Pathology Through Activation of the PPARγ Pathway. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33034847 DOI: 10.1007/s13311-020-00943-1   
2020 Du Y, Luo M, Du Y, Xu M, Yao Q, Wang K, He G. Liquiritigenin Decreases Aβ Levels and Ameliorates Cognitive Decline by Regulating Microglia M1/M2 Transformation in AD Mice. Neurotoxicity Research. PMID 32990912 DOI: 10.1007/s12640-020-00284-z   
2020 Mori T, Koyama N, Yokoo T, Segawa T, Maeda M, Sawmiller D, Tan J, Town T. Gallic Acid is a Dual α/β-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice. The Journal of Biological Chemistry. PMID 32913125 DOI: 10.1074/jbc.RA119.012330   
2020 Mondal S, Vashi Y, Ghosh P, Roy D, Borthakur M, Kumar S, Iyer PK. Amyloid Targeting 'Artificial Chaperone' Impairs Oligomer Mediated Neuronal Damage and Mitochondrial Dysfunction Associated with Alzheimer Disease. Acs Chemical Neuroscience. PMID 32941009 DOI: 10.1021/acschemneuro.0c00387   
2020 Huang L, McClatchy DB, Maher P, Liang Z, Diedrich JK, Soriano-Castell D, Goldberg J, Shokhirev M, Yates JR, Schubert D, Currais A. Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death. Cell Death & Disease. 11: 828. PMID 33024077 DOI: 10.1038/s41419-020-03020-9   
2020 Sharma M, Tiwari V, Shukla S, Panda JJ. Fluorescent Dopamine-tryptophan nanocomposites as dual imaging and anti-aggregation agents: New generation of amyloid theranostics with trimeric effects. Acs Applied Materials & Interfaces. PMID 32870652 DOI: 10.1021/acsami.0c13223   
2020 Ahmad R, Khan A, Lee HJ, Ur Rehman I, Khan I, Alam SI, Kim MO. Lupeol, a Plant-Derived Flavonoid, Protects Mice Brains against Aβ-Induced Oxidative Stress and Neurodegeneration. Biomedicines. 8. PMID 32993092 DOI: 10.3390/biomedicines8100380   
2020 Ma WH, Chen AF, Xie XY, Huang YS. Sigma ligands as potent inhibitors of Aβ and AβOs in neurons and promising therapeutic agents of Alzheimer's disease. Neuropharmacology. 108342. PMID 33045243 DOI: 10.1016/j.neuropharm.2020.108342   
2020 Lee HJ, Woo H, Lee HE, Jeon H, Ryu KY, Nam JH, Jeon SG, Park H, Lee JS, Han KM, Lee SM, Kim J, Kang RJ, Lee YH, Kim JI, et al. The novel DYRK1A inhibitor KVN93 regulates cognitive function, amyloid-beta pathology, and neuroinflammation. Free Radical Biology & Medicine. PMID 32896600 DOI: 10.1016/j.freeradbiomed.2020.08.030   
2020 Das R, Chinnathambi S. Actin-mediated microglial chemotaxis via G-protein coupled Purinergic receptor in Alzheimer's disease. Neuroscience. PMID 32941933 DOI: 10.1016/j.neuroscience.2020.09.024   
2020 Poon CH, Wang Y, Fung ML, Zhang C, Lim LW. Rodent Models of Amyloid-Beta Feature of Alzheimer's Disease: Development and Potential Treatment Implications. Aging and Disease. 11: 1235-1259. PMID 33014535 DOI: 10.14336/AD.2019.1026   
2020 Li J, Zhuang L, Luo X, Liang J, Sun E, He Y. Protection of MCC950 against Alzheimer's disease via inhibiting neuronal pyroptosis in SAMP8 mice. Experimental Brain Research. PMID 32892233 DOI: 10.1007/s00221-020-05916-6   
2020 Gupta VB, Chitranshi N, Haan JD, Mirzaei M, You Y, Lim JK, Basavarajappa D, Godinez A, Di Angelantonio S, Sachdev P, Salekdeh GH, Bouwman F, Graham S, Gupta V. Retinal changes in Alzheimer's disease- integrated prospects of imaging, functional and molecular advances. Progress in Retinal and Eye Research. 100899. PMID 32890742 DOI: 10.1016/j.preteyeres.2020.100899   
2020 Anu K R, Das S, Joseph A, Shenoy GG, Alex AT, Mudgal J. Neurodegenerative Pathways in Alzheimer's Disease: A Review. Current Neuropharmacology. PMID 32851951 DOI: 10.2174/1570159X18666200807130637   
2020 Ju Y, Chakravarty H, Tam KY. An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease. Acs Chemical Neuroscience. PMID 33001625 DOI: 10.1021/acschemneuro.0c00464   
2020 Yang H, Mu W, Wei D, Zhang Y, Duan Y, Gao JX, Gong XQ, Wang HJ, Wu XL, Tao H, Chang J. A Novel Targeted and High-Efficiency Nanosystem for Combinational Therapy for Alzheimer's Disease. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 7: 1902906. PMID 33042734 DOI: 10.1002/advs.201902906   
2020 Kwon Y, Shin J, Nam K, An JS, Yang SH, Hong SH, Bae M, Moon K, Cho Y, Woo J, Park K, Kim K, Shin J, Kim BY, Kim Y, et al. Rhizolutin, a novel 7/10/6-tricyclic dilactone, dissociates misfolded protein aggregates and reduces apoptosis/inflammation associated with Alzheimer's disease. Angewandte Chemie (International Ed. in English). PMID 32844539 DOI: 10.1002/anie.202009294   
2020 Luo F, Sandhu AF, Rungratanawanich W, Williams GE, Akbar M, Zhou S, Song BJ, Wang X. Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases. International Journal of Molecular Sciences. 21. PMID 32998479 DOI: 10.3390/ijms21197174   
2020 Chakraborty S, ThimmaReddygari J, Selvaraj D. G-lymphatic, vascular and immune pathways for Aβ clearance cascade and therapeutic targets for Alzheimer's disease. Combinatorial Chemistry & High Throughput Screening. PMID 32875981 DOI: 10.2174/1386207323666200901095003   
2020 Ray WJ, Buggia-Prevot V. Novel Targets for Alzheimer's Disease: A View Beyond Amyloid. Annual Review of Medicine. PMID 32867590 DOI: 10.1146/annurev-med-052919-120219   
2020 Flores J, Noël A, Foveau B, Beauchet O, LeBlanc AC. Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging. Nature Communications. 11: 4571. PMID 32917871 DOI: 10.1038/s41467-020-18405-9   
2020 Simpson DSA, Oliver PL. ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease. Antioxidants (Basel, Switzerland). 9. PMID 32823544 DOI: 10.3390/antiox9080743   
2020 Park J, Won J, Seo J, Yeo HG, Kim K, Kim YG, Jeon CY, Kam MK, Kim YH, Huh JW, Lee SR, Lee DS, Lee Y. Streptozotocin Induces Alzheimer's Disease-Like Pathology in Hippocampal Neuronal Cells CDK5/Drp1-Mediated Mitochondrial Fragmentation. Frontiers in Cellular Neuroscience. 14: 235. PMID 32903692 DOI: 10.3389/fncel.2020.00235   
2020 Ma X, Huang M, Zheng M, Dai C, Song Q, Zhang Q, Li Q, Gu X, Chen H, Jiang G, Yu Y, Liu X, Li S, Wang G, Chen H, et al. ADSCs-derived extracellular vesicles alleviate neuronal damage, promote neurogenesis and rescue memory loss in mice with Alzheimer's disease. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 32931898 DOI: 10.1016/j.jconrel.2020.09.019   
2020 Ma X, Huang M, Zheng M, Dai C, Song Q, Zhang Q, Li Q, Gu X, Chen H, Jiang G, Yu Y, Liu X, Li S, Wang G, Chen H, et al. ADSCs-derived extracellular vesicles alleviate neuronal damage, promote neurogenesis and rescue memory loss in mice with Alzheimer's disease. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 32931898 DOI: 10.1016/j.jconrel.2020.09.019   
2020 Doustar J, Rentsendorj A, Torbati T, Regis GC, Fuchs DT, Sheyn J, Mirzaei N, Graham SL, Shah PK, Mastali M, Van Eyk JE, Black KL, Gupta VK, Mirzaei M, Koronyo Y, et al. Parallels between retinal and brain pathology and response to immunotherapy in old, late-stage Alzheimer's disease mouse models. Aging Cell. e13246. PMID 33090673 DOI: 10.1111/acel.13246   
2020 Garcia-Leon JA, Caceres-Palomo L, Sanchez-Mejias E, Mejias-Ortega M, Nuñez-Diaz C, Fernandez-Valenzuela JJ, Sanchez-Varo R, Davila JC, Vitorica J, Gutierrez A. Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32962164 DOI: 10.3390/ijms21186867   
2020 Hao F, Feng Y. Cannabidiol (CBD) enhanced the hippocampal immune response and autophagy of APP/PS1 Alzheimer's mice uncovered by RNA-seq. Life Sciences. 118624. PMID 33096116 DOI: 10.1016/j.lfs.2020.118624   
2020 Zhang Y, Zhao Y, Zhang J, Yang G. Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer's Disease. Neurochemical Research. PMID 32929691 DOI: 10.1007/s11064-020-03121-z   
2020 Sohrabi M, Floden AM, Manocha GD, Klug MG, Combs CK. IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer's Disease Transgenic Mouse Model. Frontiers in Cellular Neuroscience. 14: 200. PMID 32719587 DOI: 10.3389/fncel.2020.00200   
2020 Li Y, Jiang J, Tang Q, Tian H, Wang S, Wang Z, Liu H, Yang J, Ren J. Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer's Disease Animal Model. Neural Plasticity. 2020: 8867547. PMID 32952550 DOI: 10.1155/2020/8867547   
2020 Edler MK, Munger EL, Meindl RS, Hopkins WD, Ely JJ, Erwin JM, Mufson EJ, Hof PR, Sherwood CC, Raghanti MA. Neuron loss associated with age but not Alzheimer's disease pathology in the chimpanzee brain. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 375: 20190619. PMID 32951541 DOI: 10.1098/rstb.2019.0619   
2020 Zhao J, Su M, Lin Y, Liu H, He Z, Lai L. Administration of Amyloid Precursor Protein Gene Deleted Mouse ESC-Derived Thymic Epithelial Progenitors Attenuates Alzheimer's Pathology. Frontiers in Immunology. 11: 1781. PMID 32849642 DOI: 10.3389/fimmu.2020.01781   
2020 Yan L, He X, Jin Y, Wang J, Liang F, Pei R, Li P, Wang Y, Su W. Modulation of the Aβ-Peptide-Aggregation Pathway by Active Compounds From Seed Extract in Alzheimer's Disease Models. Frontiers in Aging Neuroscience. 12: 207. PMID 32922281 DOI: 10.3389/fnagi.2020.00207   
2020 Dhanwani R, Pham J, Premlal ALR, Frazier A, Kumar A, Pero ME, Bartolini F, Dutra JR, Marder KS, Peters B, Sulzer D, Sette A, Lindestam Arlehamn CS. T Cell Responses to Neural Autoantigens Are Similar in Alzheimer's Disease Patients and Age-Matched Healthy Controls. Frontiers in Neuroscience. 14: 874. PMID 32982670 DOI: 10.3389/fnins.2020.00874   
2020 Gao J, Chen X, Ma T, He B, Li P, Zhao Y, Ma Y, Zhuang J, Yin Y. PEG-Ceramide Nanomicelles Induce Autophagy and Degrade Tau Proteins in N2a Cells. International Journal of Nanomedicine. 15: 6779-6789. PMID 32982233 DOI: 10.2147/IJN.S258311   
2020 Zhang YH, Yan XZ, Xu SF, Pang ZQ, Li LB, Yang Y, Fan YG, Wang Z, Yu X, Guo C, Ao Q. α-Lipoic Acid Maintains Brain Glucose Metabolism BDNF/TrkB/HIF-1α Signaling Pathway in P301S Mice. Frontiers in Aging Neuroscience. 12: 262. PMID 32973490 DOI: 10.3389/fnagi.2020.00262   
2020 Lau SF, Cao H, Fu AKY, Ip NY. Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 32989152 DOI: 10.1073/pnas.2008762117   
2020 Kim E, Otgontenger U, Jamsranjav A, Kim SS. Deleterious Alteration of Glia in the Brain of Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32932623 DOI: 10.3390/ijms21186676   
2020 Perényi H, Szegeczki V, Horváth G, Hinnah B, Tamás A, Radák Z, Ábrahám D, Zákány R, Reglodi D, Juhász T. Physical Activity Protects the Pathological Alterations of Alzheimer's Disease Kidneys via the Activation of PACAP and BMP Signaling Pathways. Frontiers in Cellular Neuroscience. 14: 243. PMID 32922265 DOI: 10.3389/fncel.2020.00243   
2020 Broderick TL, Rasool S, Li R, Zhang Y, Anderson M, Al-Nakkash L, Plochocki JH, Geetha T, Babu JR. Neuroprotective Effects of Chronic Resveratrol Treatment and Exercise Training in the 3xTg-AD Mouse Model of Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 33020412 DOI: 10.3390/ijms21197337