| Year |
Citation |
Score |
| 2023 |
Chen J, Garcia EJ, Merritt CR, Zamora JC, Bolinger AA, Pazdrak K, Stafford SJ, Mifflin RC, Wold EA, Wild CT, Chen H, Anastasio NC, Cunningham KA, Zhou J. Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT Receptor and Dual 5-HT/5-HT Receptor Modulators. Journal of Medicinal Chemistry. PMID 37462530 DOI: 10.1021/acs.jmedchem.3c00908 |
0.711 |
|
| 2022 |
Xu J, Shi S, Liu G, Xie X, Li J, Bolinger AA, Chen H, Zhang W, Shi PY, Liu H, Zhou J. Design, synthesis, and pharmacological evaluations of pyrrolo[1,2-a]quinoxaline-based derivatives as potent and selective sirt6 activators. European Journal of Medicinal Chemistry. 246: 114998. PMID 36508969 DOI: 10.1016/j.ejmech.2022.114998 |
0.315 |
|
| 2022 |
Liu Z, Li Y, Chen H, Lai HT, Wang P, Wu SY, Wold EA, Leonard PG, Joseph S, Hu H, Chiang CM, Brasier AR, Tian B, Zhou J. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. Journal of Medicinal Chemistry. PMID 34982556 DOI: 10.1021/acs.jmedchem.1c01851 |
0.721 |
|
| 2021 |
Liu Z, Wang P, Wold EA, Song Q, Zhao C, Wang C, Zhou J. Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer. Journal of Medicinal Chemistry. PMID 33822624 DOI: 10.1021/acs.jmedchem.0c01799 |
0.719 |
|
| 2021 |
Xu J, Berastegui-Cabrera J, Carretero-Ledesma M, Chen H, Xue Y, Wold EA, Pachón J, Zhou J, Sánchez-Céspedes J. Discovery of a Small Molecule Inhibitor of Human Adenovirus Capable of Preventing Escape from the Endosome. International Journal of Molecular Sciences. 22. PMID 33562748 DOI: 10.3390/ijms22041617 |
0.699 |
|
| 2020 |
Ye N, Qin W, Tian S, Xu Q, Wold EA, Zhou J, Zhen XC. Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases. Journal of Medicinal Chemistry. PMID 33111525 DOI: 10.1021/acs.jmedchem.0c01192 |
0.719 |
|
| 2020 |
Li Z, Xu J, Lang Y, Fan X, Kuo L, D'Brant L, Hu S, Samrat S, Trudeau N, Tharappel A, Rugenstein N, Koetzner C, Zhang J, Chen H, Kramer L, ... ... Zhou J, et al. JMX0207, a niclosamide derivative with improved pharmacokinetics, suppresses Zika virus infection both in vitro and in vivo. Acs Infectious Diseases. PMID 32866370 DOI: 10.1021/Acsinfecdis.0C00217 |
0.33 |
|
| 2020 |
Zhou Z, Li X, Liu Z, Huang L, Yao Y, Li L, Chen J, Zhang R, Zhou J, Wang L, Zhang QQ. A Bromodomain-Containing Protein 4 (BRD4) Inhibitor Suppresses Angiogenesis by Regulating AP-1 Expression. Frontiers in Pharmacology. 11: 1043. PMID 32765266 DOI: 10.3389/Fphar.2020.01043 |
0.35 |
|
| 2020 |
Dvorak NM, Wadsworth PA, Wang P, Chen H, Zhou J, Laezza F. Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics. Molecules (Basel, Switzerland). 25. PMID 32722255 DOI: 10.3390/Molecules25153365 |
0.324 |
|
| 2020 |
Li Y, Liu Z, Aglyamova G, Chen J, Chen H, Bhandari M, White MA, Rudenko G, Zhou J. Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ΔFosB homodimers and ΔFosB/JunD heterodimers. Bioorganic & Medicinal Chemistry Letters. 30: 127300. PMID 32631520 DOI: 10.1016/J.Bmcl.2020.127300 |
0.321 |
|
| 2020 |
Wold EA, Garcia EJ, Wild C, Miszkiel JM, Soto CA, Chen J, Pazdrak K, Fox RG, Anastasio NC, Cunningham KA, Zhou J. Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor Positive Allosteric Modulators with Enhanced Drug-Like Properties. Journal of Medicinal Chemistry. PMID 32567857 DOI: 10.1021/Acs.Jmedchem.9B01953 |
0.748 |
|
| 2020 |
Wang P, Luchowska-Stańska U, van Basten B, Chen H, Liu Z, Wiejak J, Whelan P, Morgan D, Lochhead E, Barker G, Rehmann H, Yarwood SJ, Zhou J. Synthesis and Biochemical Evaluation of Non-Cyclic Nucleotide Exchange Protein Directly Activated by cAMP 1 (EPAC1) Regulators. Journal of Medicinal Chemistry. PMID 32340447 DOI: 10.1021/Acs.Jmedchem.9B02094 |
0.367 |
|
| 2020 |
Shao H, Mohamed H, Boulton S, Huang J, Wang P, Chen H, Zhou J, Luchowska-Stańska U, Jentsch NG, Armstrong AL, Magolan J, Yarwood S, Melacini G. Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist. Journal of Medicinal Chemistry. PMID 32297742 DOI: 10.1021/Acs.Jmedchem.9B02151 |
0.366 |
|
| 2020 |
Liu Z, Chen H, Wang P, Li Y, Wold EA, Leonard PG, Joseph S, Brasier AR, Tian B, Zhou J. Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffolding Hopping, Optimization and Pharmacological Evaluation. Journal of Medicinal Chemistry. PMID 32255647 DOI: 10.1021/Acs.Jmedchem.0C00035 |
0.749 |
|
| 2020 |
Xu J, Xie X, Chen H, Zou J, Xue Y, Ye N, Shi PY, Zhou J. Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors. Bioorganic & Medicinal Chemistry Letters. 127162. PMID 32247736 DOI: 10.1016/J.Bmcl.2020.127162 |
0.331 |
|
| 2020 |
Xu J, Shi PY, Li H, Zhou J. Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential. Acs Infectious Diseases. PMID 32125140 DOI: 10.1021/Acsinfecdis.0C00052 |
0.344 |
|
| 2020 |
Xu J, Berastegui-Cabrera J, Chen H, Pachón J, Zhou J, Sanchez-Cespedes J. Structure-Activity Relationship Studies on Diversified Salicylamide Derivatives as Potent Inhibitors of Human Adenovirus Infection. Journal of Medicinal Chemistry. PMID 32045239 DOI: 10.1021/Acs.Jmedchem.9B01950 |
0.339 |
|
| 2020 |
Lu L, Li H, Wu X, Rao J, Zhou J, Fan S, Shen Q. HJC0152 suppresses human non-small-cell lung cancer by inhibiting STAT3 and modulating metabolism. Cell Proliferation. e12777. PMID 32022328 DOI: 10.1111/Cpr.12777 |
0.313 |
|
| 2020 |
Liu Z, Uribe G, Li Y, Pingyuan W, Chen H, Brasier A, Pinchuk I, Zhou J, Tian B. 6 NOVEL BRD4 INHIBITORS BLOCK THE PATHOLOGICAL ACTIVATION OF BRD4-NFκB SIGNALING AND SUPPRESS COLONIC INFLAMMATION IN IBD MOUSE MODELS Gastroenterology. 158: S11. DOI: 10.1053/J.Gastro.2019.11.063 |
0.309 |
|
| 2020 |
Liu X, Xu J, Zhou J, Shen Q. Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance Genes and Diseases. DOI: 10.1016/J.Gendis.2020.06.010 |
0.35 |
|
| 2019 |
Brasier AR, Zhou J. Validation of the epigenetic reader bromodomain-containing protein 4 (BRD4) as a therapeutic target for treatment of airway remodeling. Drug Discovery Today. PMID 31733396 DOI: 10.1016/J.Drudis.2019.11.002 |
0.342 |
|
| 2019 |
Zhou J, Wild C. EDITORIAL; GPCR Drug Discovery: Emerging Targets, Novel Approaches and Future Trends. Current Topics in Medicinal Chemistry. PMID 31513505 DOI: 10.2174/156802661916190828093500 |
0.337 |
|
| 2019 |
Xu J, Xie X, Ye N, Zou J, Chen H, White MA, Shi PY, Zhou J. Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2',5(3H)-dione Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection. Journal of Medicinal Chemistry. PMID 31403780 DOI: 10.1021/Acs.Jmedchem.9B00698 |
0.368 |
|
| 2019 |
Wold EA, Wild CT, Cunningham KA, Zhou J. Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development. Current Topics in Medicinal Chemistry. PMID 31288724 DOI: 10.2174/1568026619666190709101449 |
0.73 |
|
| 2019 |
Liu G, Yin T, Kim H, Ding C, Yu Z, Wang H, Chen H, Yan R, Wold EA, Zou H, Liu X, Ding Y, Shen Q, Zhou J. Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer. European Journal of Medicinal Chemistry. 178: 589-605. PMID 31220676 DOI: 10.1016/J.Ejmech.2019.06.004 |
0.714 |
|
| 2019 |
Zhao Y, Bing T, Sun H, Zhang J, Zhang Y, Ivannikov M, Motamedi M, Liu Z, Zhou J, Kaphalia L, Calhoun WJ, Maroto R, Brasier AR. Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling. Journal of Proteomics. 103415. PMID 31195152 DOI: 10.1016/J.Jprot.2019.103415 |
0.332 |
|
| 2019 |
Wang P, Felsing DE, Chen H, Raval SR, Allen JA, Zhou J. Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists. Acs Medicinal Chemistry Letters. 10: 792-799. PMID 31098001 DOI: 10.1021/Acsmedchemlett.9B00050 |
0.357 |
|
| 2019 |
Liu G, Wold EA, Zhou J. Applications of Bioorthogonal Chemistry in Tumor-Targeted Drug Discovery. Current Topics in Medicinal Chemistry. PMID 31074366 DOI: 10.2174/1568026619666190510091921 |
0.72 |
|
| 2019 |
Zhou J. Norepinephrine transporter inhibitors and their therapeutic potential. Drugs of the Future. 29: 1235-1244. PMID 16871320 DOI: 10.1358/Dof.2004.029.12.855246 |
0.336 |
|
| 2019 |
Kim H, Dong J, Wang L, Xu J, Zhang D, Yan R, Zou H, Chen H, Liu X, Zhu Y, Xue Y, Zhou J, Shen Q. Abstract 5066: Chemoprevention of breast cancer by targeting glucose metabolism with HJC0152 Cancer Research. 79: 5066-5066. DOI: 10.1158/1538-7445.Am2019-5066 |
0.327 |
|
| 2018 |
Wold EA, Zhou J. GPCR Allosteric Modulators: Mechanistic Advantages and Therapeutic Applications. Current Topics in Medicinal Chemistry. 18: 2002-2006. PMID 30621563 DOI: 10.2174/1568026619999190101151837 |
0.712 |
|
| 2018 |
Ye N, Li B, Mao Q, Wold EA, Tian S, Allen JA, Zhou J. Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target. Acs Chemical Neuroscience. PMID 30540906 DOI: 10.1021/Acschemneuro.8B00572 |
0.738 |
|
| 2018 |
Wang P, Zhou J. Proteolysis Targeting Chimera (PROTAC): A Paradigm-Shifting Approach in Small Molecule Drug Discovery. Current Topics in Medicinal Chemistry. PMID 30306871 DOI: 10.2174/1568026618666181010101922 |
0.318 |
|
| 2018 |
Chen Z, Gu J, El Ayadi A, Oberhauser AF, Zhou J, Sousse LE, Finnerty CC, Herndon DN, Boor PJ. Effect of N-(2-aminoethyl) ethanolamine on hypertrophic scarring changes in vitro: Finding novel anti-fibrotic therapies. Toxicology and Applied Pharmacology. PMID 30248415 DOI: 10.1016/J.Taap.2018.09.026 |
0.305 |
|
| 2018 |
Choi EJ, Ren Y, Chen Y, Liu S, Wu W, Ren J, Wang P, Garofalo RP, Zhou J, Bao X. Exchange Proteins Directly Activated by cAMP and Their Roles in Respiratory Syncytial Virus Infection. Journal of Virology. PMID 30185593 DOI: 10.1128/Jvi.01200-18 |
0.322 |
|
| 2018 |
Tian B, Liu Z, Litvinov J, Maroto R, Jamaluddin M, Rytting E, Patrikeev I, Ochoa L, Vargas G, Motamedi M, Ameredes BT, Zhou J, Brasier AR. Efficacy of Novel Highly Specific Bromodomain-Containing Protein 4 Inhibitors in Innate Inflammation-Driven Airway Remodeling. American Journal of Respiratory Cell and Molecular Biology. PMID 30153047 DOI: 10.1165/Rcmb.2017-0445Oc |
0.338 |
|
| 2018 |
Sampson CM, Kasper JM, Felsing DE, Raval SR, Ye N, Wang P, Patrikeev I, Rytting E, Zhou J, Allen JA, Hommel JD. Small-Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models. Pharmacology Research & Perspectives. 6: e00425. PMID 30151213 DOI: 10.1002/Prp2.425 |
0.309 |
|
| 2018 |
Wold EA, Chen J, Cunningham KA, Zhou J. Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts. Journal of Medicinal Chemistry. PMID 30106578 DOI: 10.1021/Acs.Jmedchem.8B00875 |
0.745 |
|
| 2018 |
Cummins CB, Wang X, Nunez Lopez O, Graham G, Tie HY, Zhou J, Radhakrishnan RS. Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway. International Journal of Molecular Sciences. 19. PMID 29795016 DOI: 10.3390/Ijms19061567 |
0.309 |
|
| 2018 |
Wu G, Wang H, Zhou W, Zeng B, Mo W, Zhu K, Liu R, Zhou J, Chen C, Chen H. Synthesis and structure-activity relationship studies of MI-2 analogues as MALT1 inhibitors. Bioorganic & Medicinal Chemistry. PMID 29751989 DOI: 10.1016/J.Bmc.2018.04.059 |
0.381 |
|
| 2018 |
Tian B, Liu Z, Yang J, Sun H, Zhao Y, Wakamiya M, Chen H, Rytting E, Zhou J, Brasier AR. Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation. Cell Reports. 23: 1138-1151. PMID 29694891 DOI: 10.1016/J.Celrep.2018.03.106 |
0.32 |
|
| 2018 |
Liu Z, Tian B, Chen H, Wang P, Brasier AR, Zhou J. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. European Journal of Medicinal Chemistry. 151: 450-461. PMID 29649741 DOI: 10.1016/J.Ejmech.2018.04.006 |
0.37 |
|
| 2018 |
Wild CT, Miszkiel JM, Wold EA, Soto CA, Ding C, Hartley RM, White MA, Anastasio NC, Cunningham KA, Zhou J. Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-Carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor. Journal of Medicinal Chemistry. PMID 29620897 DOI: 10.1021/Acs.Jmedchem.8B00401 |
0.725 |
|
| 2018 |
Li D, Wang H, Ding Y, Zhang Z, Zheng Z, Dong J, Kim H, Meng X, Zhou Q, Zhou J, Fang L, Shen Q. Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis. Cancer Letters. PMID 29580806 DOI: 10.1016/J.Canlet.2018.03.029 |
0.329 |
|
| 2018 |
Ding Y, Li D, Ding C, Wang P, Liu Z, Wold EA, Ye N, Chen H, White MA, Shen Q, Zhou J. Regio- and Stereospecific Synthesis of Oridonin D-ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads. Journal of Medicinal Chemistry. PMID 29528645 DOI: 10.1021/Acs.Jmedchem.7B01514 |
0.739 |
|
| 2018 |
Xu J, Wold EA, Ding Y, Shen Q, Zhou J. Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection. Molecules (Basel, Switzerland). 23. PMID 29470395 DOI: 10.3390/Molecules23020474 |
0.731 |
|
| 2018 |
Lin Y, Liu R, Zhao P, Ye J, Zheng Z, Huang J, Zhang Y, Gao Y, Chen H, Liu S, Zhou J, Chen C, Chen H. Discovery of novel mifepristone derivatives via suppressing KLF5 expression for the treatment of triple-negative breast cancer. European Journal of Medicinal Chemistry. 146: 354-367. PMID 29407962 DOI: 10.1016/J.Ejmech.2018.01.056 |
0.377 |
|
| 2018 |
Ding Y, Li D, Ding C, Liu Z, Wold EA, Ye N, Chen H, White MA, Shen Q, Zhou J. Abstract 2668: Regio- and stereospecific synthesis of oridonin D-ring aziridinated analogues for the treatment of triple-negative breast cancer via mediated irreversible covalent warheads Cancer Research. 78: 2668-2668. DOI: 10.1158/1538-7445.Am2018-2668 |
0.724 |
|
| 2017 |
Liu Z, Zhu Y, Chen H, Wang P, Mei FC, Ye N, Cheng X, Zhou J. Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs). Bioorganic & Medicinal Chemistry Letters. PMID 29100797 DOI: 10.1016/J.Bmcl.2017.10.056 |
0.401 |
|
| 2017 |
Levesley J, Steele L, Brüning-Richardson A, Davison A, Zhou J, Ding C, Lawler S, Short SC. Selective BCL-XL inhibition promotes apoptosis in combination with MLN8237 in medulloblastoma and pediatric glioblastoma cells. Neuro-Oncology. PMID 29016820 DOI: 10.1093/Neuonc/Nox134 |
0.311 |
|
| 2017 |
Chen Z, Wu Q, Ding Y, Zhou W, Liu R, Chen H, Zhou J, Feng J, Chen C. YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway. Theranostics. 7: 2339-2349. PMID 28740556 DOI: 10.7150/Thno.17555 |
0.344 |
|
| 2017 |
Li Z, Brecher M, Deng YQ, Zhang J, Sakamuru S, Liu B, Huang R, Koetzner CA, Allen CA, Jones SA, Chen H, Zhang NN, Tian M, Gao F, Lin Q, ... ... Zhou J, et al. Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction. Cell Research. PMID 28685770 DOI: 10.1038/Cr.2017.88 |
0.383 |
|
| 2017 |
Ye N, Zhu Y, Liu Z, Mei FC, Chen H, Wang P, Cheng X, Zhou J. Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists. European Journal of Medicinal Chemistry. 134: 62-71. PMID 28399451 DOI: 10.1016/J.Ejmech.2017.04.001 |
0.388 |
|
| 2017 |
Li R, Ding C, Zhang J, Xie M, Park D, Ding Y, Chen G, Zhang G, Gilbert-Ross M, Zhou W, Marcus A, Sun SY, Chen ZG, Sica GL, Ramalingam SS, ... ... Zhou J, et al. Modulation of Bax and mTOR for cancer therapeutics. Cancer Research. PMID 28381544 DOI: 10.1158/0008-5472.Can-16-2356 |
0.331 |
|
| 2017 |
Zhou J, Yun EJ, Chen W, Ding Y, Wu K, Wang B, Ding C, Hernandez E, Santoyo J, Pong RC, Chen H, He D, Zhou J, Hsieh JT. Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs. Cell Death & Disease. 8: e2701. PMID 28333136 DOI: 10.1038/Cddis.2017.121 |
0.38 |
|
| 2017 |
Wang P, Liu Z, Chen H, Ye N, Cheng X, Zhou J. Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets. Bioorganic & Medicinal Chemistry Letters. PMID 28283242 DOI: 10.1016/J.Bmcl.2017.02.065 |
0.393 |
|
| 2017 |
Liu Z, Wang P, Chen H, Wold EA, Tian B, Brasier AR, Zhou J. Drug Discovery Targeting Bromodomain-Containing Protein 4 (BRD4). Journal of Medicinal Chemistry. PMID 28195723 DOI: 10.1021/Acs.Jmedchem.6B01761 |
0.742 |
|
| 2017 |
Dong J, Li D, Kim H, Wang H, Zheng Z, Zhang Z, Ye N, Chen H, Zhou J, Shen Q. Abstract LB-299: Glucose metabolism modulator HJC0152 differentially regulates glycolytic enzymes to suppress breast carcinogenesis Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-299 |
0.355 |
|
| 2017 |
Li R, Ding C, Zhang J, Xie M, Park D, Ding Y, Chen G, Zhang G, Gilbert-Ross M, Zhou W, Marcus A, Sun S, Chen Z, Sica G, Ramalingam S, ... ... Zhou J, et al. Abstract 2333: Modulation of Bax and mTOR for cancer therapeutics Cancer Research. 77: 2333-2333. DOI: 10.1158/1538-7445.Am2017-2333 |
0.346 |
|
| 2017 |
Wong J, Ali SR, Wadsworth P, Singh AK, Liu Z, Chen H, Zhou J, Laezza F. Virtual Screening in Search of Allosteric Modulators of Nav1.1 Channels Biophysical Journal. 112: 242a. DOI: 10.1016/J.Bpj.2016.11.1325 |
0.332 |
|
| 2016 |
Lopez ON, Bohanon FJ, Wang X, Ye N, Corsello T, Rojas-Khalil Y, Chen H, Chen H, Zhou J, Radhakrishnan RS. STAT3 Inhibition Suppresses Hepatic Stellate Cell Fibrogenesis: HJC0123, a Potential Therapeutic Agent for Liver Fibrosis. Rsc Advances. 6: 100652-100663. PMID 28546859 DOI: 10.1039/C6Ra17459K |
0.329 |
|
| 2016 |
Ye N, Chen H, Wold EA, Shi PY, Zhou J. Therapeutic Potential of Spirooxindoles as Antiviral Agents. Acs Infectious Diseases. 2: 382-392. PMID 27627626 DOI: 10.1021/Acsinfecdis.6B00041 |
0.731 |
|
| 2016 |
Chen W, Zhou J, Wu K, Huang J, Ding Y, Yun EJ, Wang B, Ding C, Hernandez E, Santoyo J, Chen H, Lin H, Sagalowsky A, He D, Zhou J, et al. Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues. Oncotarget. PMID 27472396 DOI: 10.18632/Oncotarget.10863 |
0.313 |
|
| 2016 |
Wu J, Ding Y, Chen CH, Zhou Z, Ding C, Chen H, Zhou J, Chen C. A new oridonin analog suppresses triple-negative breast cancer cells and tumor growth via the induction of death receptor 5. Cancer Letters. PMID 27387452 DOI: 10.1016/J.Canlet.2016.06.024 |
0.319 |
|
| 2016 |
Ding Y, Ding C, Ye N, Liu Z, Wold EA, Chen H, Wild C, Shen Q, Zhou J. Discovery and development of natural product oridonin-inspired anticancer agents. European Journal of Medicinal Chemistry. 122: 102-117. PMID 27344488 DOI: 10.1016/J.Ejmech.2016.06.015 |
0.745 |
|
| 2016 |
Qi C, Bin Li, Yang Y, Yang Y, Li J, Zhou Q, Wen Y, Zeng C, Zheng L, Zhang Q, Li J, He X, Zhou J, Shao C, Wang L. Glipizide suppresses prostate cancer progression in the TRAMP model by inhibiting angiogenesis. Scientific Reports. 6: 27819. PMID 27292155 DOI: 10.1038/Srep27819 |
0.325 |
|
| 2016 |
Wild CT, Zhu Y, Na Y, Mei F, Ynalvez MA, Chen H, Cheng X, Zhou J. Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors. Acs Medicinal Chemistry Letters. 7: 460-464. PMID 27190593 DOI: 10.1021/Acsmedchemlett.5B00477 |
0.337 |
|
| 2016 |
Chen H, Wu J, Gao Y, Chen H, Zhou J. Scaffold Repurposing of Old Drugs Towards New Cancer Drug Discovery. Current Topics in Medicinal Chemistry. PMID 26881709 DOI: 10.2174/1568026616666160216155556 |
0.367 |
|
| 2016 |
Zou H, Ye N, Pang H, Zhang D, Yan R, Chen H, Cai G, Wang L, Yang Z, Chen H, Xu G, Zhang Y, Arora R, Tan M, Wei Y, ... Zhou J, et al. Abstract 329: Reprogramming glucose metabolism and energy production with a small molecule HJC0152 suppresses breast cancer development and progression to metastasis Cancer Research. 76: 329-329. DOI: 10.1158/1538-7445.Am2016-329 |
0.325 |
|
| 2016 |
Bohanon F, Wang X, Lopez ON, Vasudevan S, Chen H, Zhou J, Radhakrishnan R. Tu1729 Suppression of Hepatic Stellate Cell Activation by HJC0123, a Novel Small-Molecule Inhibitor of STAT3 Gastroenterology. 150: S1259. DOI: 10.1016/S0016-5085(16)34254-8 |
0.31 |
|
| 2016 |
Lopez ON, Wang X, Bohanon FJ, Kandathiparampil A, Ye N, Vasudevan SJ, Chen H, Zhou J, Radhakrishnan RS. HJC0416, a Small-Molecule Inhibitor of STAT3, Exhibits Anti-Fibrogenic Properties on Activated Hepatic Stellate Cells Journal of the American College of Surgeons. 223: e137-e138. DOI: 10.1016/J.Jamcollsurg.2016.08.352 |
0.302 |
|
| 2015 |
Liu Z, Wild C, Ding Y, Ye N, Chen H, Wold EA, Zhou J. BH4 domain of Bcl-2 as a novel target for cancer therapy. Drug Discovery Today. PMID 26631752 DOI: 10.1016/J.Drudis.2015.11.008 |
0.712 |
|
| 2015 |
Bohanon FJ, Wang X, Graham BM, Ding C, Ding Y, Radhakrishnan GL, Rastellini C, Zhou J, Radhakrishnan RS. Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis. The Journal of Surgical Research. PMID 26409288 DOI: 10.1016/J.Jss.2015.07.042 |
0.307 |
|
| 2015 |
Liu Z, Ding Y, Ye N, Wild C, Chen H, Zhou J. Direct Activation of Bax Protein for Cancer Therapy. Medicinal Research Reviews. PMID 26395559 DOI: 10.1002/Med.21379 |
0.362 |
|
| 2015 |
Bohanon FJ, Wang X, Graham BM, Prasai A, Vasudevan SJ, Ding C, Ding Y, Radhakrishnan GL, Rastellini C, Zhou J, Radhakrishnan RS. Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells. Molecular and Cellular Biochemistry. PMID 26346163 DOI: 10.1007/S11010-015-2562-4 |
0.303 |
|
| 2015 |
Ye N, Zhu Y, Chen H, Liu Z, Mei FC, Wild C, Chen H, Cheng X, Zhou J. Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists. Journal of Medicinal Chemistry. 58: 6033-47. PMID 26151319 DOI: 10.1021/Acs.Jmedchem.5B00635 |
0.398 |
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| 2015 |
Han B, Park D, Li R, Xie M, Owonikoko TK, Zhang G, Sica GL, Ding C, Zhou J, Magis AT, Chen ZG, Shin DM, Ramalingam SS, Khuri FR, Curran WJ, et al. Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy. Cancer Cell. 27: 852-63. PMID 26004684 DOI: 10.1016/J.Ccell.2015.04.010 |
0.316 |
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| 2015 |
Zhu Y, Chen H, Boulton S, Mei F, Ye N, Melacini G, Zhou J, Cheng X. Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window". Scientific Reports. 5: 9344. PMID 25791905 DOI: 10.1038/Srep09344 |
0.377 |
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| 2015 |
Gao Y, Ding Y, Chen H, Chen H, Zhou J. Targeting Krüppel-like factor 5 (KLF5) for cancer therapy. Current Topics in Medicinal Chemistry. 15: 699-713. PMID 25732792 DOI: 10.2174/1568026615666150302105052 |
0.366 |
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| 2015 |
Chen H, Gao Y, Wang A, Zhou X, Zheng Y, Zhou J. Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents. European Journal of Medicinal Chemistry. 92: 648-55. PMID 25617694 DOI: 10.1016/J.Ejmech.2015.01.031 |
0.351 |
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| 2015 |
Chen H, Zhou X, Wang A, Zheng Y, Gao Y, Zhou J. Evolutions in fragment-based drug design: the deconstruction-reconstruction approach. Drug Discovery Today. 20: 105-13. PMID 25263697 DOI: 10.1016/J.Drudis.2014.09.015 |
0.356 |
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| 2015 |
Wang L, Yang Z, Xia Q, Chen H, Cai G, Wild C, Zhou J, Shen Q. Abstract P6-12-04: Targeting STAT3 with novel small molecule inhibitors to sensitize breast cancer cells to radiation therapy Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P6-12-04 |
0.327 |
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| 2015 |
Han B, Park D, Li R, Xie M, Owonikoko T, Sica G, Ding C, Zhou J, Magis A, Ramalingam S, Khuri F, Curran W, Deng X. Abstract 2922: Development of Bcl2 BH4 antagonist for cancer therapy Cancer Research. 75: 2922-2922. DOI: 10.1158/1538-7445.Am2015-2922 |
0.331 |
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| 2015 |
Zatarain JR, Mrazek AA, Johnson P, Pang L, Ding Y, Zhou J, Szabo C, Chao C, Hellmich MR. Tu1975 H2S Inhibition of Cystathionine-β-Synthase (CBS) Using Novel Prodrug Decreases Colorectal Cancer Xenograft Growth With Less Toxicity Than Aminooxyacetic Acid (AOAA) Gastroenterology. 148: S-950. DOI: 10.1016/S0016-5085(15)33242-X |
0.324 |
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| 2015 |
Wild C, Ding C, Zhang G, Anastasio N, Moncrief JS, Carbonaro T, Fox R, Stutz S, Hartley R, Smith T, Cunningham K, Zhou J. Targeting the serotonin (5-HT) 5-HT2c receptor: Rational design of small molecule allosteric modulators to treat psychostimulant use disorders Drug and Alcohol Dependence. 146: e23. DOI: 10.1016/J.Drugalcdep.2014.09.742 |
0.301 |
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| 2015 |
Ali SR, Liu Z, Nenov MN, Panova-Elektro NI, Zhou J, Stoilova-McPhie S, Laezza F. Targeting Protein:Protein Interaction Sites for Drug Development against Voltage-Gated Sodium Channels Biophysical Journal. 108: 574a. DOI: 10.1016/J.Bpj.2014.11.3140 |
0.32 |
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| 2014 |
Qi C, Zhou Q, Li B, Yang Y, Cao L, Ye Y, Li J, Ding Y, Wang H, Wang J, He X, Zhang Q, Lan T, Lee KK, Li W, ... ... Zhou J, et al. Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis. Oncotarget. 5: 9966-79. PMID 25294818 DOI: 10.18632/Oncotarget.2483 |
0.345 |
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| 2014 |
Xin M, Li R, Xie M, Park D, Owonikoko TK, Sica GL, Corsino PE, Zhou J, Ding C, White MA, Magis AT, Ramalingam SS, Curran WJ, Khuri FR, Deng X. Small-molecule Bax agonists for cancer therapy. Nature Communications. 5: 4935. PMID 25230299 DOI: 10.1038/Ncomms5935 |
0.343 |
|
| 2014 |
Chen H, Gao Y, Wu J, Chen Y, Chen B, Hu J, Zhou J. Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies. Cancer Letters. 354: 5-11. PMID 25128647 DOI: 10.1016/J.Canlet.2014.08.003 |
0.345 |
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| 2014 |
Chen H, Yang Z, Ding C, Xiong A, Wild C, Wang L, Ye N, Cai G, Flores RM, Ding Y, Shen Q, Zhou J. Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). European Journal of Medicinal Chemistry. 82: 195-203. PMID 24904966 DOI: 10.1016/J.Ejmech.2014.05.049 |
0.389 |
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| 2014 |
Chen H, Mrazek AA, Wang X, Ding C, Ding Y, Porro LJ, Liu H, Chao C, Hellmich MR, Zhou J. Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo. Bioorganic & Medicinal Chemistry. 22: 3393-404. PMID 24837156 DOI: 10.1016/J.Bmc.2014.04.043 |
0.356 |
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| 2014 |
Ye N, Ding Y, Wild C, Shen Q, Zhou J. Small molecule inhibitors targeting activator protein 1 (AP-1). Journal of Medicinal Chemistry. 57: 6930-48. PMID 24831826 DOI: 10.1021/Jm5004733 |
0.363 |
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| 2014 |
Xiong A, Yang Z, Shen Y, Zhou J, Shen Q. Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention. Cancers. 6: 926-57. PMID 24743778 DOI: 10.3390/Cancers6020926 |
0.367 |
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| 2014 |
Chen H, Wild C, Zhou X, Ye N, Cheng X, Zhou J. Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC). Journal of Medicinal Chemistry. 57: 3651-65. PMID 24256330 DOI: 10.1021/Jm401425E |
0.366 |
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| 2014 |
Xiong A, Chen H, Yang Z, Cai G, Wang L, Ding C, Xu GG, Wild C, Ye N, Uray IP, Zhou J, Shen Q. Abstract 3805: Anticancer agent HJC0416 inhibits the growth of breast cancer xenografts via downregulating STAT3 signaling Cancer Research. 74: 3805-3805. DOI: 10.1158/1538-7445.Am2014-3805 |
0.335 |
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| 2013 |
Ding C, Zhang Y, Chen H, Yang Z, Wild C, Ye N, Ester CD, Xiong A, White MA, Shen Q, Zhou J. Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis. Journal of Medicinal Chemistry. 56: 8814-25. PMID 24128046 DOI: 10.1021/Jm401248X |
0.37 |
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| 2013 |
Ding C, Zhang Y, Chen H, Yang Z, Wild C, Chu L, Liu H, Shen Q, Zhou J. Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility. Journal of Medicinal Chemistry. 56: 5048-58. PMID 23746196 DOI: 10.1021/Jm400367N |
0.377 |
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| 2013 |
Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q, Zhou J. Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents. Acs Medicinal Chemistry Letters. 4: 180-185. PMID 23459613 DOI: 10.1021/Ml3003082 |
0.379 |
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| 2013 |
Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q, Zhou J. Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy. European Journal of Medicinal Chemistry. 62: 498-507. PMID 23416191 DOI: 10.1016/J.Ejmech.2013.01.023 |
0.42 |
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| 2013 |
Chen H, Tsalkova T, Chepurny OG, Mei FC, Holz GG, Cheng X, Zhou J. Identification and characterization of small molecules as potent and specific EPAC2 antagonists. Journal of Medicinal Chemistry. 56: 952-62. PMID 23286832 DOI: 10.1021/Jm3014162 |
0.36 |
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| 2013 |
Chen H, Wang CZ, Ding C, Wild C, Copits B, Swanson GT, Johnson KM, Zhou J. A combined bioinformatics and chemoinformatics approach for developing asymmetric bivalent AMPA receptor positive allosteric modulators as neuroprotective agents. Chemmedchem. 8: 226-30. PMID 23281122 DOI: 10.1002/Cmdc.201200554 |
0.352 |
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| 2013 |
Almahariq M, Tsalkova T, Mei FC, Chen H, Zhou J, Sastry SK, Schwede F, Cheng X. A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Molecular Pharmacology. 83: 122-8. PMID 23066090 DOI: 10.1124/Mol.112.080689 |
0.373 |
|
| 2013 |
Yang Z, Chen H, Ding C, Wild C, Zhou J, Shen Q. Abstract B33: Target STAT3 signaling for the prevention of ER-negative breast cancer Cancer Prevention Research. 6. DOI: 10.1158/1940-6215.Prev-13-B33 |
0.32 |
|
| 2013 |
Yang Z, Chen H, Chu L, Zhang Y, Ding C, Liu H, Zhou J, Shen Q. Abstract 872: Novel potent and orally active STAT3 inhibitors for cancer therapies. Cancer Research. 73: 872-872. DOI: 10.1158/1538-7445.Am2013-872 |
0.377 |
|
| 2013 |
Zhang Y, Ding C, Yang Z, Chen H, Chu L, Zhou J, Shen Q. Abstract 5573: Discovery of potent oridonin derivatives for the treatment of breast cancer. Cancer Research. 73: 5573-5573. DOI: 10.1158/1538-7445.Am2013-5573 |
0.351 |
|
| 2013 |
Ding C, Zhang Y, Chen H, Yang Z, Chu L, Wild C, White MA, Shen Q, Zhou J. Abstract 2267: Natural product-inspired drug discovery: Chemistry and biology of oridonin analogs with unique scaffolds and enhanced anticancer profiles . Cancer Research. 73: 2267-2267. DOI: 10.1158/1538-7445.Am2013-2267 |
0.41 |
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| 2013 |
Chen H, Wang CZ, Ding C, Wild C, Copits B, Swanson GT, Johnson KM, Zhou J. Back Cover: A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents (ChemMedChem 2/2013) Chemmedchem. 8: 344-344. DOI: 10.1002/Cmdc.201390004 |
0.315 |
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| 2012 |
Chen H, Tsalkova T, Mei FC, Hu Y, Cheng X, Zhou J. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorganic & Medicinal Chemistry Letters. 22: 4038-43. PMID 22607683 DOI: 10.1016/J.Bmcl.2012.04.082 |
0.391 |
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| 2010 |
Caldarone BJ, Paterson NE, Zhou J, Brunner D, Kozikowski AP, Westphal KG, Korte-Bouws GA, Prins J, Korte SM, Olivier B, Ghavami A. The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties. The Journal of Pharmacology and Experimental Therapeutics. 335: 762-70. PMID 20864506 DOI: 10.1124/Jpet.110.174011 |
0.528 |
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| 2010 |
Zhou J, Qiu Y, Feng K, Chen R. ChemInform Abstract: Facile and Stereospecific Synthesis of cis-3-(N′-Arylureido)-2,3-dihydro-2-phenyl-1,2-benzoxaphosphole 2-Oxides. Cheminform. 30: no-no. DOI: 10.1002/chin.199924179 |
0.479 |
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| 2010 |
Zhou J, Chen R. ChemInform Abstract: A Facile Synthesis of New 2-Phosphonobenzyloxy-1,3,2-benzoxaza(dioxa or diaza)phospholes. Cheminform. 30: no-no. DOI: 10.1002/chin.199918165 |
0.499 |
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| 2010 |
Zhou J, Qiu Y, Feng K, Chen R. ChemInform Abstract: Studies on Cyclic α-Aminoalkanephosphonate Compounds: A Novel Synthesis of 2-Phenyl-1,4,2-benzoxaza (or diaza)phosphorin 2-Oxides. Cheminform. 30: no-no. DOI: 10.1002/chin.199917177 |
0.521 |
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| 2010 |
ZHOU J, CHEN R. ChemInform Abstract: Desulfurization Reaction of cis-1,2-Diphenyl-3-aryl-1,4,2-diazaphospholidin-5-thione-2-oxides Utilizing an Ag+-H2O or ROH System. Cheminform. 29: no-no. DOI: 10.1002/chin.199852075 |
0.471 |
|
| 2010 |
ZHOU J, CHEN R, YANG X. ChemInform Abstract: Synthesis of Novel Thio(seleno) Phosphate-phosphonates and Their Biological Activities. Cheminform. 29: no-no. DOI: 10.1002/chin.199840185 |
0.537 |
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| 2008 |
Yamamoto T, Kozikowski A, Zhou J, Neale JH. Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain. Molecular Pain. 4: 31. PMID 18673570 DOI: 10.1186/1744-8069-4-31 |
0.484 |
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| 2008 |
Zhang B, West EJ, Van KC, Gurkoff GG, Zhou J, Zhang XM, Kozikowski AP, Lyeth BG. HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats. Brain Research. 1226: 181-91. PMID 18582446 DOI: 10.1016/J.Brainres.2008.05.085 |
0.458 |
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| 2008 |
Olszewski RT, Wegorzewska MM, Monteiro AC, Krolikowski KA, Zhou J, Kozikowski AP, Long K, Mastropaolo J, Deutsch SI, Neale JH. Phencyclidine and Dizocilpine Induced Behaviors Reduced by N-acetylaspartylglutamate Peptidase Inhibition via Metabotropic Glutamate Receptors Biological Psychiatry. 63: 86-91. PMID 17597589 DOI: 10.1016/J.Biopsych.2007.04.016 |
0.498 |
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| 2007 |
Maloney DJ, Ghanem N, Zhou J, Hecht SM. Positional assignment of differentially substituted bisaminoacylated pdCpAs. Organic & Biomolecular Chemistry. 5: 3135-8. PMID 17878972 DOI: 10.1039/B708786A |
0.434 |
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| 2007 |
Yamamoto T, Saito O, Aoe T, Bartolozzi A, Sarva J, Zhou J, Kozikowski A, Wroblewska B, Bzdega T, Neale JH. Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. The European Journal of Neuroscience. 25: 147-58. PMID 17241276 DOI: 10.1111/J.1460-9568.2006.05272.X |
0.494 |
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| 2006 |
Musachio JL, Hong J, Ichise M, Seneca N, Brown AK, Liow JS, Halldin C, Innis RB, Pike VW, He R, Zhou J, Kozikowski AP. Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 3101-4. PMID 16621532 DOI: 10.1016/J.Bmcl.2006.03.066 |
0.491 |
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| 2006 |
Zhong C, Zhao X, Van KC, Bzdega T, Smyth A, Zhou J, Kozikowski AP, Jiang J, O'Connor WT, Berman RF, Neale JH, Lyeth BG. NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat. Journal of Neurochemistry. 97: 1015-25. PMID 16606367 DOI: 10.1111/J.1471-4159.2006.03786.X |
0.47 |
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| 2006 |
Wang B, Zhou J, Lodder M, Anderson RD, Hecht SM. Tandemly activated tRNAs as participants in protein synthesis. The Journal of Biological Chemistry. 281: 13865-8. PMID 16556606 DOI: 10.1074/Jbc.C600018200 |
0.724 |
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| 2006 |
Wee S, Wang Z, He R, Zhou J, Kozikowski AP, Woolverton WL. Role of the increased noradrenergic neurotransmission in drug self-administration. Drug and Alcohol Dependence. 82: 151-7. PMID 16213110 DOI: 10.1016/J.Drugalcdep.2005.09.002 |
0.455 |
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| 2005 |
Zhou J, Neale JH, Pomper MG, Kozikowski AP. NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nature Reviews. Drug Discovery. 4: 1015-26. PMID 16341066 DOI: 10.1038/Nrd1903 |
0.556 |
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| 2005 |
Guilarte TR, McGlothan JL, Foss CA, Zhou J, Heston WD, Kozikowski AP, Pomper MG. Glutamate carboxypeptidase II levels in rodent brain using [125I]DCIT quantitative autoradiography. Neuroscience Letters. 387: 141-4. PMID 16006038 DOI: 10.1016/J.Neulet.2005.06.015 |
0.48 |
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| 2005 |
Zhou J, Kläss T, Johnson KM, Giberson KM, Kozikowski AP. Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants. Bioorganic & Medicinal Chemistry Letters. 15: 2461-5. PMID 15863297 DOI: 10.1016/J.Bmcl.2005.03.083 |
0.552 |
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| 2004 |
Zhou J, He R, Johnson KM, Ye Y, Kozikowski AP. Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization. Journal of Medicinal Chemistry. 47: 5821-4. PMID 15537337 DOI: 10.1021/Jm040117O |
0.519 |
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| 2004 |
Yamamoto T, Hirasawa S, Wroblewska B, Grajkowska E, Zhou J, Kozikowski A, Wroblewski J, Neale JH. Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model. The European Journal of Neuroscience. 20: 483-94. PMID 15233757 DOI: 10.1111/J.1460-9568.2004.03504.X |
0.406 |
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| 2004 |
Olszewski RT, Bukhari N, Zhou J, Kozikowski AP, Wroblewski JT, Shamimi-Noori S, Wroblewska B, Bzdega T, Vicini S, Barton FB, Neale JH. NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. Journal of Neurochemistry. 89: 876-85. PMID 15140187 DOI: 10.1111/J.1471-4159.2004.02358.X |
0.507 |
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| 2003 |
Zhou J, Kläss T, Zhang A, Johnson KM, Wang CZ, Ye Y, Kozikowski AP. Synthesis and pharmacological evaluation of (Z)-9-(heteroarylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes: thiophene analogues as potent norepinephrine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 3565-9. PMID 14505672 DOI: 10.1016/S0960-894X(03)00786-8 |
0.532 |
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| 2003 |
Quinlivan M, Mattner F, Papazian V, Zhou J, Katsifis A, Emond P, Chalon S, Kozikowski A, Guilloteau D, Kassiou M. Synthesis and evaluation of iodine-123 labelled tricyclic tropanes as radioligands for the serotonin transporter. Nuclear Medicine and Biology. 30: 741-6. PMID 14499332 DOI: 10.1016/S0969-8051(03)00076-3 |
0.496 |
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| 2003 |
Zhou J, Zhang A, Kläss T, Johnson KM, Wang CZ, Ye YP, Kozikowski AP. Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites. Journal of Medicinal Chemistry. 46: 1997-2007. PMID 12723962 DOI: 10.1021/Jm020596W |
0.533 |
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| 2002 |
Anderson RD, Zhou J, Hecht SM. Fluorescence resonance energy transfer between unnatural amino acids in a structurally modified dihydrofolate reductase. Journal of the American Chemical Society. 124: 9674-5. PMID 12175203 DOI: 10.1021/Ja0205939 |
0.626 |
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| 2000 |
Wang B, Lodder M, Zhou J, Baird TT, Brown KC, Craik CS, Hecht SM. Chemically mediated site-specific cleavage of proteins [9] Journal of the American Chemical Society. 122: 7402-7403. DOI: 10.1021/Ja0002262 |
0.653 |
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| 1998 |
Zhou J, Chen R. Desulfurization reaction ofcis-1,2-diphenyl-3-aryl-1,4,2-diazaphospholidin-5-thione-2-oxides utilizing an Ag+?H2O or ROH system Heteroatom Chemistry. 9: 585-590. DOI: 10.1002/(Sici)1098-1071(1998)9:6<585::Aid-Hc10>3.0.Co;2-N |
0.471 |
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