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Yorgo E. Modis - Publications

Affiliations: 
Molecular Biophysics and Biochemistry Yale University, New Haven, CT 
Area:
molecular mechanisms of host-pathogen interactions using X-ray crystallography, microscopy, and other biophysical and biochemical approaches
Website:
http://medicine.yale.edu/mbb/faculty/yorgo_modis.profile
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50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Pokorny L, Burden JJ, Albrecht D, Bamford R, Leigh KE, Sridhar P, Knowles TJ, Modis Y, Mercer J. The vaccinia chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion. Embo Reports. PMID 38321165 DOI: 10.1038/s44319-023-00040-2  0.306
2024 Stoll GA, Nikolopoulos N, Zhai H, Zhang L, Douse CH, Modis Y. Crystal structure and biochemical activity of the macrodomain from rubella virus p150. Journal of Virology. e0177723. PMID 38289106 DOI: 10.1128/jvi.01777-23  0.349
2019 Hwang MS, Boulanger J, Howe JD, Albecka A, Pasche M, Mureşan L, Modis Y. MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling. The Febs Journal. PMID 30715798 DOI: 10.1111/Febs.14772  0.347
2019 Stoll GA, Oda S, Chong Z, Yu M, McLaughlin SH, Modis Y. Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing Proceedings of the National Academy of Sciences of the United States of America. 116: 15042-15051. DOI: 10.2210/Pdb6Qaj/Pdb  0.389
2018 Douse CH, Bloor S, Liu Y, Shamin M, Tchasovnikarova IA, Timms RT, Lehner PJ, Modis Y. Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms. Nature Communications. 9: 651. PMID 29440755 DOI: 10.1038/S41467-018-03045-X  0.373
2018 Yu Q, Qu K, Modis Y. Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Molecular Cell. 72: 999. DOI: 10.2210/Pdb6G1X/Pdb  0.399
2017 Fenwick MK, Li Y, Cresswell P, Modis Y, Ealick SE. Structural studies of viperin, an antiviral radical SAM enzyme. Proceedings of the National Academy of Sciences of the United States of America. PMID 28607080 DOI: 10.1073/Pnas.1705402114  0.382
2016 Willensky S, Bar-Rogovsky H, Bignon EA, Tischler ND, Modis YE, Dessau M. Crystal Structure of Glycoprotein C from a Hantavirus in the Post-fusion Conformation. Plos Pathogens. 12. PMID 27783673 DOI: 10.1371/Journal.Ppat.1005948  0.754
2016 Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, ... ... Modis Y, et al. Data publication with the structural biology data grid supports live analysis. Nature Communications. 7: 10882. PMID 26947396 DOI: 10.1038/Ncomms10882  0.717
2015 Esposito DL, Nguyen JB, DeWitt DC, Rhoades E, Modis Y. Physicochemical requirements and kinetics of membrane fusion of flavivirus-like particles. The Journal of General Virology. PMID 25740960 DOI: 10.1099/Vir.0.000113  0.612
2014 Reikine S, Nguyen JB, Modis Y. Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5. Frontiers in Immunology. 5: 342. PMID 25101084 DOI: 10.3389/Fimmu.2014.00342  0.598
2014 Wang J, Li Y, Modis Y. Exploiting subtle structural differences in heavy-atom derivatives for experimental phasing. Acta Crystallographica Section D-Biological Crystallography. 70: 1873-1883. PMID 25004964 DOI: 10.1107/S1399004714008943  0.357
2014 Nour AM, Modis Y. Endosomal vesicles as vehicles for viral genomes. Trends in Cell Biology. 24: 449-54. PMID 24746011 DOI: 10.1016/J.Tcb.2014.03.006  0.337
2014 Wang J, Li Y, Modis Y. Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses Virology. 454: 93-101. PMID 24725935 DOI: 10.1016/J.Virol.2014.02.015  0.381
2014 Li Y, Modis Y. A novel membrane fusion protein family in Flaviviridae Trends in Microbiology. 22: 176-182. PMID 24569295 DOI: 10.1016/J.Tim.2014.01.008  0.443
2014 Modis Y. Relating structure to evolution in class II viral membrane fusion proteins Current Opinion in Virology. 5: 34-41. PMID 24525225 DOI: 10.1016/J.Coviro.2014.01.009  0.395
2013 Nour AM, Li Y, Wolenski J, Modis Y. Viral membrane fusion and nucleocapsid delivery into the cytoplasm are distinct events in some flaviviruses. Plos Pathogens. 9: e1003585. PMID 24039574 DOI: 10.1371/Journal.Ppat.1003585  0.378
2013 Nguyen JB, Pool CD, Wong CY, Treger RS, Williams DL, Cappello M, Lea WA, Simeonov A, Vermeire JJ, Modis Y. Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A. Chemistry & Biology. 20: 991-1001. PMID 23891152 DOI: 10.1016/J.Chembiol.2013.06.011  0.603
2013 Modis Y. Class II fusion proteins. Advances in Experimental Medicine and Biology. 790: 150-166. PMID 23884590 DOI: 10.1007/978-1-4614-7651-1_8  0.435
2013 Ryslik GA, Cheng Y, Cheung KH, Modis Y, Zhao H. Utilizing protein structure to identify non-random somatic mutations Bmc Bioinformatics. 14. PMID 23758891 DOI: 10.1186/1471-2105-14-190  0.301
2013 Li Y, Wang J, Kanai R, Modis Y. Crystal structure of glycoprotein E2 from bovine viral diarrhea virus. Proceedings of the National Academy of Sciences of the United States of America. 110: 6805-10. PMID 23569276 DOI: 10.1073/Pnas.1300524110  0.463
2013 Hakim A, Nguyen JB, Basu K, Zhu DF, Thakral D, Davies PL, Isaacs FJ, Modis Y, Meng W. Crystal structure of an insect antifreeze protein and its implications for ice binding. The Journal of Biological Chemistry. 288: 12295-304. PMID 23486477 DOI: 10.1074/Jbc.M113.450973  0.607
2013 Dessau M, Modis Y. Crystal structure of glycoprotein C from Rift Valley fever virus Proceedings of the National Academy of Sciences of the United States of America. 110: 1696-1701. PMID 23319635 DOI: 10.1073/Pnas.1217780110  0.758
2013 Berke IC, Li Y, Modis Y. Structural basis of innate immune recognition of viral RNA. Cellular Microbiology. 15: 386-394. PMID 23110455 DOI: 10.1111/Cmi.12061  0.317
2013 Nguyen JB, Modis Y. Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1. Journal of Structural Biology. 181: 82-8. PMID 23099021 DOI: 10.1016/J.Jsb.2012.10.006  0.615
2013 Dessau M, Modis Y. Crystal structure of glycoprotein C from Rift Valley fever virus F1000research. 4. DOI: 10.7490/F1000Research.1092907.1  0.726
2012 Dessau M, Goldhill D, McBride R, McBride RL, Turner PE, Modis Y. Selective pressure causes an RNA virus to trade reproductive fitness for increased structural and thermal stability of a viral enzyme. Plos Genetics. 8: e1003102. PMID 23209446 DOI: 10.1371/Journal.Pgen.1003102  0.718
2012 Berke IC, Yu X, Modis Y, Egelman EH. MDA5 assembles into a polar helical filament on dsRNA. Proceedings of the National Academy of Sciences of the United States of America. 109: 18437-41. PMID 23090998 DOI: 10.1073/Pnas.1212186109  0.35
2012 Duan X, Li Y, Rajan NK, Routenberg DA, Modis Y, Reed MA. Quantification of the affinities and kinetics of protein interactions using silicon nanowire biosensors. Nature Nanotechnology. 7: 401-7. PMID 22635097 DOI: 10.1038/Nnano.2012.82  0.306
2012 Modis Y. Exploiting structural biology in the fight against parasitic diseases. Trends in Parasitology. 28: 124-130. PMID 22341779 DOI: 10.1016/J.Pt.2012.01.003  0.312
2012 Berke IC, Modis Y. MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA. The Embo Journal. 31: 1714-1726. PMID 22314235 DOI: 10.1038/Emboj.2012.19  0.348
2012 Zhou K, Kanai R, Lee P, Wang HW, Modis Y. Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin. Journal of Structural Biology. 177: 402-9. PMID 22173220 DOI: 10.1016/J.Jsb.2011.12.002  0.347
2011 Kucera K, Harrison LM, Cappello M, Modis Y. Ancylostoma ceylanicum excretory-secretory protein 2 adopts a netrin-like fold and defines a novel family of nematode proteins. Journal of Molecular Biology. 408: 9-17. PMID 21352830 DOI: 10.1016/J.Jmb.2011.02.033  0.651
2011 Dessau MA, Modis Y. Protein crystallization for X-ray crystallography. Journal of Visualized Experiments. 190-195. PMID 21304455 DOI: 10.3791/2285  0.713
2010 Kucera K, Koblansky AA, Saunders LP, Frederick KB, De La Cruz EM, Ghosh S, Modis Y. Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11. Journal of Molecular Biology. 403: 616-29. PMID 20851125 DOI: 10.1016/J.Jmb.2010.09.022  0.617
2009 Nayak V, Dessau M, Kucera K, Anthony K, Ledizet M, Modis Y. Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation and its implications for membrane fusion. Journal of Virology. 83: 4338-44. PMID 19244332 DOI: 10.1128/Jvi.02574-08  0.777
2008 Modis Y. How influenza virus is locked out of the cell Proceedings of the National Academy of Sciences of the United States of America. 105: 18647-18648. PMID 19033206 DOI: 10.1073/Pnas.0810508106  0.393
2007 Arjona A, Ledizet M, Anthony K, Bonafé N, Modis Y, Town T, Fikrig E. West Nile virus envelope protein inhibits dsRNA-induced innate immune responses. Journal of Immunology (Baltimore, Md. : 1950). 179: 8403-9. PMID 18056386 DOI: 10.4049/Jimmunol.179.12.8403  0.37
2006 Kanai R, Kar K, Anthony K, Gould LH, Ledizet M, Fikrig E, Marasco WA, Koski RA, Modis Y. Crystal structure of west nile virus envelope glycoprotein reveals viral surface epitopes. Journal of Virology. 80: 11000-8. PMID 16943291 DOI: 10.1128/Jvi.01735-06  0.459
2005 Modis Y, Ogata S, Clements D, Harrison SC. Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein. Journal of Virology. 79: 1223-31. PMID 15613349 DOI: 10.1128/Jvi.79.2.1223-1231.2005  0.582
2004 Modis Y, Ogata S, Clements D, Harrison SC. Structure of the dengue virus envelope protein after membrane fusion. Nature. 427: 313-9. PMID 14737159 DOI: 10.1038/Nature02165  0.602
2004 Van den Berg B, Clemons WM, Collinson I, Modis Y, Hartmann E, Harrison SC, Rapoport TA. X-ray structure of a protein-conducting channel. Nature. 427: 36-44. PMID 14661030 DOI: 10.1038/Nature02218  0.537
2003 Modis Y, Ogata S, Clements D, Harrison SC. A ligand-binding pocket in the dengue virus envelope glycoprotein. Proceedings of the National Academy of Sciences of the United States of America. 100: 6986-91. PMID 12759475 DOI: 10.1073/Pnas.0832193100  0.59
2002 Modis Y, Trus BL, Harrison SC. Atomic model of the papillomavirus capsid. The Embo Journal. 21: 4754-62. PMID 12234916 DOI: 10.1093/Emboj/Cdf494  0.513
2002 Boll W, Rapoport I, Brunner C, Modis Y, Prehn S, Kirchhausen T. The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites. Traffic (Copenhagen, Denmark). 3: 590-600. PMID 12121421 DOI: 10.1034/J.1600-0854.2002.30808.X  0.545
2000 Modis Y, Wierenga RK. Crystallographic analysis of the reaction pathway of Zoogloea ramigera biosynthetic thiolase. Journal of Molecular Biology. 297: 1171-82. PMID 10764581 DOI: 10.1006/Jmbi.2000.3638  0.579
1999 Modis Y, Wierenga RK. A biosynthetic thiolase in complex with a reaction intermediate: the crystal structure provides new insights into the catalytic mechanism. Structure (London, England : 1993). 7: 1279-90. PMID 10545327 DOI: 10.1016/S0969-2126(00)80061-1  0.607
1998 Modis Y, Wierenga R. Two crystal structures of N-acetyltransferases reveal a new fold for CoA-dependent enzymes Structure. 6: 1345-1350. PMID 9817851 DOI: 10.1016/S0969-2126(98)00134-8  0.583
1998 Modis Y, Filppula SA, Novikov DK, Norledge B, Hiltunen JK, Wierenga RK. The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate sidechains for catalysis. Structure (London, England : 1993). 6: 957-70. PMID 9739087 DOI: 10.1016/S0969-2126(98)00098-7  0.616
1997 Mathieu M, Modis Y, Zeelen JP, Engel CK, Abagyan RA, Ahlberg A, Rasmussen B, Lamzin VS, Kunau WH, Wierenga RK. The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism. Journal of Molecular Biology. 273: 714-28. PMID 9402066 DOI: 10.1006/Jmbi.1997.1331  0.612
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