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Douglas Hanahan - Publications

Affiliations: 
1978-1988 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 
 1988-2010 Cell Biology University of California, San Francisco, San Francisco, CA 
 2010- École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 
Area:
Genetics, Cell Biology, Oncology
Website:
https://people.epfl.ch/douglas.hanahan
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63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Chryplewicz A, Scotton J, Tichet M, Zomer A, Shchors K, Joyce JA, Homicsko K, Hanahan D. Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity. Cancer Cell. PMID 36113478 DOI: 10.1016/j.ccell.2022.08.014  0.311
2021 Saghafinia S, Homicsko K, Di Domenico A, Wullschleger S, Perren A, Marinoni I, Ciriello G, Michael IP, Hanahan D. Cancer cells retrace a stepwise differentiation program during malignant progression. Cancer Discovery. PMID 33910926 DOI: 10.1158/2159-8290.CD-20-1637  0.355
2019 Galliverti G, Wullschleger S, Tichet M, Murugan D, Zangger N, Horton W, Korman AJ, Coussens LM, Swartz MA, Hanahan D. Myeloid cells orchestrate systemic immunosuppression, impairing the efficacy of immunotherapy against HPV+ cancers. Cancer Immunology Research. PMID 31771984 DOI: 10.1158/2326-6066.Cir-19-0315  0.533
2018 Li L, Zeng Q, Bhutkar A, Galván JA, Karamitopoulou E, Noordermeer D, Peng MW, Piersigilli A, Perren A, Zlobec I, Robinson H, Iruela-Arispe ML, Hanahan D. GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth. Cancer Cell. PMID 29606348 DOI: 10.1016/J.Ccell.2018.02.011  0.32
2015 Gunderson AJ, Kaneda MM, Tsujikawa T, Nguyen AV, Affara NI, Ruffell B, Gorjestani S, Liudahl SM, Truitt M, Olson P, Kim G, Hanahan D, Tempero MA, Sheppard B, Irving B, et al. Bruton's Tyrosine Kinase (BTK)-dependent immune cell crosstalk drives pancreas cancer. Cancer Discovery. PMID 26715645 DOI: 10.1158/2159-8290.Cd-15-0827  0.546
2015 Sadanandam A, Wullschleger S, Lyssiotis CA, Grotzinger C, Barbi S, Bersani S, Korner J, Wafy I, Mafficini A, Lawlor RT, Simbolo M, Asara JM, Blaker H, Cantley LC, Wiedenmann B, ... Hanahan D, et al. A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics. Cancer Discovery. PMID 26446169 DOI: 10.1158/2159-8290.Cd-15-0068  0.622
2013 De Palma M, Coukos G, Hanahan D. A new twist on radiation oncology: low-dose irradiation elicits immunostimulatory macrophages that unlock barriers to tumor immunotherapy. Cancer Cell. 24: 559-61. PMID 24229704 DOI: 10.1016/J.Ccr.2013.10.019  0.308
2013 Hunter KE, Quick ML, Sadanandam A, Hanahan D, Joyce JA. Identification and characterization of poorly differentiated invasive carcinomas in a mouse model of pancreatic neuroendocrine tumorigenesis. Plos One. 8: e64472. PMID 23691228 DOI: 10.1371/Journal.Pone.0064472  0.326
2013 Sadanandam A, Lyssiotis CA, Homicsko K, Collisson EA, Gibb WJ, Wullschleger S, Ostos LC, Lannon WA, Grotzinger C, Del Rio M, Lhermitte B, Olshen AB, Wiedenmann B, Cantley LC, Gray JW, Hanahan D, et al. A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nature Medicine. 19: 619-25. PMID 23584089 DOI: 10.1038/Nm.3175  0.576
2013 Shchors K, Nozawa H, Xu J, Rostker F, Swigart-Brown L, Evan G, Hanahan D. Increased invasiveness of MMP-9-deficient tumors in two mouse models of neuroendocrine tumorigenesis. Oncogene. 32: 502-13. PMID 22391572 DOI: 10.1038/Onc.2012.60  0.322
2012 Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 21: 309-22. PMID 22439926 DOI: 10.1016/J.Ccr.2012.02.022  0.547
2011 Falcon BL, Pietras K, Chou J, Chen D, Sennino B, Hanahan D, McDonald DM. Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B. The American Journal of Pathology. 178: 2920-30. PMID 21641409 DOI: 10.1016/j.ajpath.2011.02.019  0.312
2011 Xie L, Duncan MB, Pahler J, Sugimoto H, Martino M, Lively J, Mundel T, Soubasakos M, Rubin K, Takeda T, Inoue M, Lawler J, Hynes RO, Hanahan D, Kalluri R. Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proceedings of the National Academy of Sciences of the United States of America. 108: 9939-44. PMID 21622854 DOI: 10.1073/Pnas.1105041108  0.319
2011 Sodir NM, Swigart LB, Karnezis AN, Hanahan D, Evan GI, Soucek L. Endogenous Myc maintains the tumor microenvironment. Genes & Development. 25: 907-16. PMID 21478273 DOI: 10.1101/Gad.2038411  0.302
2011 Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 144: 646-74. PMID 21376230 DOI: 10.1016/J.Cell.2011.02.013  0.307
2010 Chun MG, Hanahan D. Genetic deletion of the desmosomal component desmoplakin promotes tumor microinvasion in a mouse model of pancreatic neuroendocrine carcinogenesis. Plos Genetics. 6: e1001120. PMID 20862307 DOI: 10.1371/Journal.Pgen.1001120  0.664
2010 Chun MG, Mao JH, Chiu CW, Balmain A, Hanahan D. Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 17268-73. PMID 20855625 DOI: 10.1073/Pnas.1012705107  0.659
2010 Ulanet DB, Hanahan D. Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms. Plos One. 5: e12454. PMID 20805995 DOI: 10.1371/journal.pone.0012454  0.33
2010 Erez N, Truitt M, Olson P, Arron ST, Hanahan D. Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. Cancer Cell. 17: 135-47. PMID 20138012 DOI: 10.1016/j.ccr.2009.12.041  0.321
2009 Olson P, Lu J, Zhang H, Shai A, Chun MG, Wang Y, Libutti SK, Nakakura EK, Golub TR, Hanahan D. MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer. Genes & Development. 23: 2152-65. PMID 19759263 DOI: 10.1101/Gad.1820109  0.61
2009 Pàez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Viñals F, Inoue M, Bergers G, Hanahan D, Casanovas O. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 15: 220-31. PMID 19249680 DOI: 10.1016/J.Ccr.2009.01.027  0.302
2009 Hager JH, Ulanet DB, Hennighausen L, Hanahan D. Genetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancer. Plos One. 4: e4455. PMID 19209227 DOI: 10.1371/journal.pone.0004455  0.31
2008 Pahler JC, Tazzyman S, Erez N, Chen YY, Murdoch C, Nozawa H, Lewis CE, Hanahan D. Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response. Neoplasia (New York, N.Y.). 10: 329-40. PMID 18392134 DOI: 10.1593/Neo.07871  0.3
2008 Pietras K, Pahler J, Bergers G, Hanahan D. Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. Plos Medicine. 5: e19. PMID 18232728 DOI: 10.1371/Journal.Pmed.0050019  0.322
2007 Du YC, Lewis BC, Hanahan D, Varmus H. Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion. Plos Biology. 5: e276. PMID 17941720 DOI: 10.1371/Journal.Pbio.0050276  0.363
2007 Bell-McGuinn KM, Garfall AL, Bogyo M, Hanahan D, Joyce JA. Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer. Cancer Research. 67: 7378-85. PMID 17671208 DOI: 10.1158/0008-5472.Can-07-0602  0.301
2006 Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes & Development. 20: 3130-46. PMID 17114584 DOI: 10.1101/Gad.1478706  0.326
2006 Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D, Joyce JA. Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes & Development. 20: 543-56. PMID 16481467 DOI: 10.1101/Gad.1407406  0.352
2005 Casanovas O, Hager JH, Chun MG, Hanahan D. Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis. Oncogene. 24: 6597-604. PMID 16007165 DOI: 10.1038/sj.onc.1208823  0.674
2005 Joyce JA, Freeman C, Meyer-Morse N, Parish CR, Hanahan D. A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer. Oncogene. 24: 4037-51. PMID 15806157 DOI: 10.1038/Sj.Onc.1208602  0.314
2004 Astrof S, Crowley D, George EL, Fukuda T, Sekiguchi K, Hanahan D, Hynes RO. Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis. Molecular and Cellular Biology. 24: 8662-70. PMID 15367684 DOI: 10.1128/Mcb.24.19.8662-8670.2004  0.322
2004 Joyce JA, Baruch A, Chehade K, Meyer-Morse N, Giraudo E, Tsai FY, Greenbaum DC, Hager JH, Bogyo M, Hanahan D. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell. 5: 443-53. PMID 15144952 DOI: 10.1016/S1535-6108(04)00111-4  0.354
2003 Hanahan D, Lanzavecchia A, Mihich E. Fourteenth Annual Pezcoller Symposium: the novel dichotomy of immune interactions with tumors. Cancer Research. 63: 3005-8. PMID 12782611  0.318
2003 Daniel D, Meyer-Morse N, Bergsland EK, Dehne K, Coussens LM, Hanahan D. Immune enhancement of skin carcinogenesis by CD4+ T cells. The Journal of Experimental Medicine. 197: 1017-28. PMID 12695493 DOI: 10.1084/Jem.20021047  0.51
2002 Cao ZA, Daniel D, Hanahan D. Sub-lethal radiation enhances anti-tumor immunotherapy in a transgenic mouse model of pancreatic cancer. Bmc Cancer. 2: 11. PMID 12019035 DOI: 10.1186/1471-2407-2-11  0.317
2001 Qian F, Hanahan D, Weissman IL. L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America. 98: 3976-81. PMID 11274419 DOI: 10.1073/pnas.061633698  0.428
2000 Coussens LM, Tinkle CL, Hanahan D, Werb Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell. 103: 481-90. PMID 11081634 DOI: 10.1016/S0092-8674(00)00139-2  0.618
2000 Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nature Cell Biology. 2: 737-44. PMID 11025665 DOI: 10.1038/35036374  0.416
1999 Coussens LM, Raymond WW, Bergers G, Laig-Webster M, Behrendtsen O, Werb Z, Caughey GH, Hanahan D. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes & Development. 13: 1382-97. PMID 10364156 DOI: 10.1101/Gad.13.11.1382  0.645
1999 Bergers G, Javaherian K, Lo KM, Folkman J, Hanahan D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science (New York, N.Y.). 284: 808-12. PMID 10221914 DOI: 10.1126/Science.284.5415.808  0.317
1998 Bergers G, Hanahan D, Coussens LM. Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis. The International Journal of Developmental Biology. 42: 995-1002. PMID 9853830  0.57
1998 Ganss R, Hanahan D. Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes. Cancer Research. 58: 4673-81. PMID 9788621  0.357
1998 Olson DC, Deng C, Hanahan D. Fibroblast growth factor receptor 4, implicated in progression of islet cell carcinogenesis by its expression profile, does not contribute functionally. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 9: 557-64. PMID 9690623  0.356
1998 Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, Shapiro SD, Senior RM, Werb Z. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell. 93: 411-22. PMID 9590175 DOI: 10.1016/S0092-8674(00)81169-1  0.43
1997 Kash SF, Johnson RS, Tecott LH, Noebels JL, Mayfield RD, Hanahan D, Baekkeskov S. Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proceedings of the National Academy of Sciences of the United States of America. 94: 14060-5. PMID 9391152 DOI: 10.1073/Pnas.94.25.14060  0.41
1997 Speiser DE, Miranda R, Zakarian A, Bachmann MF, McKall-Faienza K, Odermatt B, Hanahan D, Zinkernagel RM, Ohashi PS. Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy. The Journal of Experimental Medicine. 186: 645-53. PMID 9271580 DOI: 10.1084/Jem.186.5.645  0.302
1997 Shi YP, Naik P, Dietrich WF, Gray JW, Hanahan D, Pinkel D. DNA copy number changes associated with characteristic LOH in islet cell carcinomas of transgenic mice Genes Chromosomes and Cancer. 19: 104-111. PMID 9172001 DOI: 10.1002/(Sici)1098-2264(199706)19:2<104::Aid-Gcc6>3.0.Co;2-2  0.312
1996 Naik P, Karrim J, Hanahan D. The rise and fall of apoptosis during multistage tumorigenesis: Down- modulation contributes to tumor progression from angiogenic progenitors Genes and Development. 10: 2105-2116. PMID 8804306  0.316
1996 Johnson R, Spiegelman B, Hanahan D, Wisdom R. Cellular transformation and malignancy induced by ras require c-jun Molecular and Cellular Biology. 16: 4504-4511. PMID 8754851 DOI: 10.1128/Mcb.16.8.4504  0.553
1996 Parangi S, O'Reilly M, Christofori G, Holmgren L, Grosfeld J, Folkman J, Hanahan D. Antiangiogenic therapy of transgenic mice impairs de novo tumor growth Proceedings of the National Academy of Sciences of the United States of America. 93: 2002-2007. PMID 8700875 DOI: 10.1073/Pnas.93.5.2002  0.347
1995 Vivanco MD, Johnson R, Galante PE, Hanahan D, Yamamoto KR. A transition in transcriptional activation by the glucocorticoid and retinoic acid receptors at the tumor stage of dermal fibrosarcoma development. The Embo Journal. 14: 2217-28. PMID 7774580 DOI: 10.1002/J.1460-2075.1995.Tb07216.X  0.538
1994 Christofori G, Hanahan D. Molecular dissection of multi-stage tumorigenesis in transgenic mice Seminars in Cancer Biology. 5: 3-12. PMID 8186386  0.349
1994 Dietrich WF, Radany EH, Smith JS, Bishop JM, Hanahan D, Lander ES. Genome-wide search for loss of heterozygosity in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosomes 9 and 16 Proceedings of the National Academy of Sciences of the United States of America. 91: 9451-9455. PMID 7937788 DOI: 10.1073/Pnas.91.20.9451  0.467
1991 Hicks BA, Stein R, Efrat S, Grant S, Hanahan D, Demetriou AA. Transplantation of beta cells from transgenic mice into nude athymic diabetic rats restores glucose regulation. Diabetes Research and Clinical Practice. 14: 157-64. PMID 1778108 DOI: 10.1016/0168-8227(91)90016-7  0.462
1991 Folkman J, Hanahan D. Switch to the angiogenic phenotype during tumorigenesis Princess Takamatsu Symposia. 22: 339-347. PMID 1726933  0.342
1991 Knowles BB, Faas S, Juretic A, Fox N, Crooke R, Hanahan D, Solter D, Jewett L. SV40 T antigen transgenic mice: cytotoxic T lymphocytes as a selective force in tumor progression Basic Life Sciences. 57: 111-124; discussion . PMID 1726037 DOI: 10.1007/978-1-4684-5994-4_11  0.327
1991 Grant SG, Seidman I, Hanahan D, Bautch VL. Early invasiveness characterizes metastatic carcinoid tumors in transgenic mice. Cancer Research. 51: 4917-23. PMID 1654206  0.365
1988 Efrat S, Linde S, Kofod H, Spector D, Delannoy M, Grant S, Hanahan D, Baekkeskov S. Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene. Proceedings of the National Academy of Sciences of the United States of America. 85: 9037-41. PMID 2848253 DOI: 10.1073/Pnas.85.23.9037  0.524
1983 Hanahan D, Meselson M. Plasmid screening at high colony density. Methods in Enzymology. 100: 333-42. PMID 6194407 DOI: 10.1016/0076-6879(83)00066-X  0.487
1981 Wozney J, Hanahan D, Tate V, Boedtker H, Doty P. Structure of the pro α2(I) collagen gene Nature. 294: 129-135. PMID 6272119 DOI: 10.1038/294129A0  0.45
1981 Wozney J, Hanahan D, Morimoto R, Boedtker H, Doty P. Fine structural analysis of the chicken pro α2 collagen gene Proceedings of the National Academy of Sciences of the United States of America. 78: 712-716. PMID 6262763 DOI: 10.1073/Pnas.78.2.712  0.455
1980 Hanahan D, Meselson M. Plasmid screening at high colony density. Gene. 10: 63-7. PMID 6997135 DOI: 10.1016/0378-1119(80)90144-4  0.494
1978 Lehrach H, Frischauf AM, Hanahan D, Wozney J, Fuller F, Crkvenjakov R, Boedtker H, Doty P. Construction and characterization of a 2.5-kilobase procollagen clone Proceedings of the National Academy of Sciences of the United States of America. 75: 5417-5421. PMID 364479 DOI: 10.1073/Pnas.75.11.5417  0.44
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