| Year |
Citation |
Score |
| 2019 |
Cheng AC, Doherty EM, Johnstone S, DiMauro EF, Dao J, Luthra A, Ye J, Tang J, Nixey T, Min X, Tagari P, Miranda LP, Wang Z. Structure-guided discovery of dual recognition chemibodies Acta Crystallographica Section A. 75. DOI: 10.1107/S0108767319097836 |
0.332 |
|
| 2018 |
Cheng AC, Doherty EM, Johnstone S, DiMauro EF, Dao J, Luthra A, Ye J, Tang J, Nixey T, Min X, Tagari P, Miranda LP, Wang Z. Structure-guided Discovery of Dual-recognition Chemibodies. Scientific Reports. 8: 7570. PMID 29765112 DOI: 10.2210/Pdb5Vta/Pdb |
0.311 |
|
| 2014 |
Loving KA, Lin A, Cheng AC. Structure-based druggability assessment of the mammalian structural proteome with inclusion of light protein flexibility. Plos Computational Biology. 10: e1003741. PMID 25079060 DOI: 10.1371/Journal.Pcbi.1003741 |
0.314 |
|
| 2013 |
Gustin DJ, Li Y, Brown ML, Min X, Schmitt MJ, Wanska M, Wang X, Connors R, Johnstone S, Cardozo M, Cheng AC, Jeffries S, Franks B, Li S, Shen S, et al. Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 4608-16. PMID 23845219 DOI: 10.1016/J.Bmcl.2013.06.030 |
0.321 |
|
| 2012 |
Huang H, La DS, Cheng AC, Whittington DA, Patel VF, Chen K, Dineen TA, Epstein O, Graceffa R, Hickman D, Kiang YH, Louie S, Luo Y, Wahl RC, Wen PH, et al. Structure- and property-based design of aminooxazoline xanthenes as selective, orally efficacious, and CNS penetrable BACE inhibitors for the treatment of Alzheimer's disease. Journal of Medicinal Chemistry. 55: 9156-69. PMID 22928914 DOI: 10.1021/Jm300598E |
0.322 |
|
| 2012 |
Bryan MC, Whittington DA, Doherty EM, Falsey JR, Cheng AC, Emkey R, Brake RL, Lewis RT. Rapid development of piperidine carboxamides as potent and selective anaplastic lymphoma kinase inhibitors. Journal of Medicinal Chemistry. 55: 1698-705. PMID 22263917 DOI: 10.1021/Jm201565S |
0.329 |
|
| 2011 |
Liu JJ, Cheng AC, Tang HL, Medina JC. Benzodiazepinone Derivatives as CRTH2 Antagonists. Acs Medicinal Chemistry Letters. 2: 515-8. PMID 24900341 DOI: 10.1021/Ml200019Y |
0.388 |
|
| 2011 |
Schenkel LB, Huang X, Cheng A, Deak HL, Doherty E, Emkey R, Gu Y, Gunaydin H, Kim JL, Lee J, Loberg R, Olivieri P, Pistillo J, Tang J, Wan Q, et al. Discovery of potent and highly selective thienopyridine Janus kinase 2 inhibitors. Journal of Medicinal Chemistry. 54: 8440-50. PMID 22087750 DOI: 10.1021/Jm200911R |
0.328 |
|
| 2011 |
Peterson ML, Stanton MK, Kelly RC, Staples R, Cheng A. Preparation, solid state characterization, and single crystal structure analysis of N-(4-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)benzo[d] thiazol-2-yl)acetamide crystal forms Crystengcomm. 13: 1170-1180. DOI: 10.1039/C0Ce00544D |
0.355 |
|
| 2010 |
Cee VJ, Schenkel LB, Hodous BL, Deak HL, Nguyen HN, Olivieri PR, Romero K, Bak A, Be X, Bellon S, Bush TL, Cheng AC, Chung G, Coats S, Eden PM, et al. Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor. Journal of Medicinal Chemistry. 53: 6368-77. PMID 20684549 DOI: 10.1021/Jm100394Y |
0.312 |
|
| 2010 |
Liu H, Kuhn C, Feru F, Jacques SL, Deshmukh GD, Ye P, Rennie GR, Johnson T, Kazmirski S, Low S, Coli R, Ding YH, Cheng AC, Tecle H, English JM, et al. Enhanced selectivity profile of pyrazole-urea based DFG-out p38α inhibitors Bioorganic and Medicinal Chemistry Letters. 20: 4885-4891. PMID 20620059 DOI: 10.1016/J.Bmcl.2010.06.073 |
0.393 |
|
| 2010 |
Patel SD, Habeski WM, Cheng AC, Cruz Edl, Loh C, Kablaoui NM. Corrigendum to "Quinazolin-4-piperidin-4-methyl sulfamide PC-1 inhibitors: Alleviating hERG interactions through structure based design" [Bioorg. Med. Chem. Lett. 19 (2009) 3339] (DOI:10.1016/j.bmcl.2009.04.006) Bioorganic and Medicinal Chemistry Letters. 20: 2685. DOI: 10.1016/J.Bmcl.2010.01.024 |
0.378 |
|
| 2009 |
Tecle H, Feru F, Liu H, Kuhn C, Rennie G, Morris M, Shao J, Cheng AC, Gikunju D, Miret J, Coli R, Xi SH, Clugston SL, Low S, Kazmirski S, et al. The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay. Chemical Biology & Drug Design. 74: 547-59. PMID 19843080 DOI: 10.1111/J.1747-0285.2009.00884.X |
0.303 |
|
| 2009 |
Czyznikowska Z, Lipkowski P, Góra RW, Zaleśny R, Cheng AC. On the nature of intermolecular interactions in nucleic acid base-amino acid side-chain complexes. The Journal of Physical Chemistry. B. 113: 11511-20. PMID 19637846 DOI: 10.1021/Jp904146M |
0.461 |
|
| 2009 |
Patel SD, Habeski WM, Cheng AC, de la Cruz E, Loh C, Kablaoui NM. Quinazolin-4-piperidin-4-methyl sulfamide PC-1 inhibitors: alleviating hERG interactions through structure based design. Bioorganic & Medicinal Chemistry Letters. 19: 3339-43. PMID 19435660 DOI: 10.1016/J.Bmcl.2009.04.006 |
0.323 |
|
| 2009 |
Stockman BJ, Kothe M, Kohls D, Weibley L, Connolly BJ, Sheils AL, Cao Q, Cheng AC, Yang L, Kamath AV, Ding YH, Charlton ME. Identification of allosteric PIF-pocket ligands for PDK1 using NMR-based fragment screening and 1H- 15N TROSY experiments Chemical Biology and Drug Design. 73: 179-188. PMID 19207420 DOI: 10.1111/J.1747-0285.2008.00768.X |
0.348 |
|
| 2008 |
Deak HL, Newcomb JR, Nunes JJ, Boucher C, Cheng AC, DiMauro EF, Epstein LF, Gallant P, Hodous BL, Huang X, Lee JH, Patel VF, Schneider S, Turci SM, Zhu X. N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR. Bioorganic & Medicinal Chemistry Letters. 18: 1172-6. PMID 18083554 DOI: 10.1016/J.Bmcl.2007.11.123 |
0.406 |
|
| 2007 |
Kothe M, Kohls D, Low S, Coli R, Cheng AC, Jacques SL, Johnson TL, Lewis C, Loh C, Nonomiya J, Sheils AL, Verdries KA, Wynn TA, Kuhn C, Ding YH. Structure of the catalytic domain of human polo-like kinase 1. Biochemistry. 46: 5960-71. PMID 17461553 DOI: 10.1021/Bi602474J |
0.335 |
|
| 2007 |
Cheng AC, Coleman RG, Smyth KT, Cao Q, Soulard P, Caffrey DR, Salzberg AC, Huang ES. Structure-based maximal affinity model predicts small-molecule druggability. Nature Biotechnology. 25: 71-5. PMID 17211405 DOI: 10.1038/Nbt1273 |
0.33 |
|
| 2006 |
Coleman RG, Salzberg AC, Cheng AC. Structure-based identification of small molecule binding sites using a free energy model. Journal of Chemical Information and Modeling. 46: 2631-7. PMID 17125203 DOI: 10.1021/Ci600229Z |
0.316 |
|
| 2004 |
Cheng AC, Frankel AD. Ab initio interaction energies of hydrogen-bonded amino acid side chain[bond]nucleic acid base interactions. Journal of the American Chemical Society. 126: 434-5. PMID 14719918 DOI: 10.1021/Ja037264G |
0.694 |
|
| 2003 |
Cheng AC, Chen WW, Fuhrmann CN, Frankel AD. Recognition of nucleic acid bases and base-pairs by hydrogen bonding to amino acid side-chains. Journal of Molecular Biology. 327: 781-96. PMID 12654263 DOI: 10.1016/S0022-2836(03)00091-3 |
0.731 |
|
| 2003 |
Walberer BJ, Cheng AC, Frankel AD. Structural diversity and isomorphism of hydrogen-bonded base interactions in nucleic acids. Journal of Molecular Biology. 327: 767-80. PMID 12654262 DOI: 10.1016/S0022-2836(03)00090-1 |
0.435 |
|
| 2001 |
Cheng AC, Calabro V, Frankel AD. Design of RNA-binding proteins and ligands Current Opinion in Structural Biology. 11: 478-484. PMID 11495742 DOI: 10.1016/S0959-440X(00)00236-0 |
0.587 |
|
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