Cesare Montecucco - Publications

Affiliations: 
University of Padua, Padova, Veneto, Italy 

228 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Pirazzini M, Grinzato A, Corti D, Barbieri S, Leka O, Vallese F, Tonellato M, Silacci-Fregni C, Piccoli L, Kandiah E, Schiavo G, Zanotti G, Lanzavecchia A, Montecucco C. Exceptionally potent human monoclonal antibodies are effective for prophylaxis and treatment of tetanus in mice. The Journal of Clinical Investigation. 131. PMID 34618682 DOI: 10.1172/JCI151676  0.463
2020 Stazi M, D'Este G, Mattarei A, Negro S, Lista F, Rigoni M, Megighian A, Montecucco C. An agonist of the CXCR4 receptor accelerates the recovery from the peripheral neuroparalysis induced by Taipan snake envenomation. Plos Neglected Tropical Diseases. 14: e0008547. PMID 32898186 DOI: 10.1371/Journal.Pntd.0008547  0.31
2020 Rossetto O, Pirazzini M, Fabris F, Montecucco C. Botulinum Neurotoxins: Mechanism of Action. Handbook of Experimental Pharmacology. PMID 32277300 DOI: 10.1007/164_2020_355  0.372
2019 Rossetto O, Montecucco C. Tables of Toxicity of Botulinum and Tetanus Neurotoxins. Toxins. 11. PMID 31771110 DOI: 10.3390/Toxins11120686  0.328
2019 Negro S, Zanetti G, Mattarei A, Valentini A, Megighian A, Tombesi G, Zugno A, Dianin V, Pirazzini M, Fillo S, Lista F, Rigoni M, Montecucco C. An Agonist of the CXCR4 Receptor Strongly Promotes Regeneration of Degenerated Motor Axon Terminals. Cells. 8. PMID 31575088 DOI: 10.3390/Cells8101183  0.305
2019 Rossetto O, Pirazzini M, Lista R, Montecucco C. The role of the single interchains disulfide bond in Tetanus and Botulinum Neurotoxins and the development of anti-tetanus and anti-botulism drugs. Cellular Microbiology. e13037. PMID 31050145 DOI: 10.1111/Cmi.13037  0.327
2018 Negro S, Stazi M, Marchioretto M, Tebaldi T, Rodella U, Duregotti E, Gerke V, Quattrone A, Montecucco C, Rigoni M, Viero G. Hydrogen peroxide is a neuronal alarmin that triggers specific RNAs, local translation of Annexin A2 and cytoskeletal remodeling in Schwann cells. Rna (New York, N.Y.). PMID 29643068 DOI: 10.1261/Rna.064816.117  0.317
2018 Doxey AC, Mansfield MJ, Montecucco C. Discovery of novel bacterial toxins by genomics and computational biology. Toxicon : Official Journal of the International Society On Toxinology. PMID 29438679 DOI: 10.1016/J.Toxicon.2018.02.002  0.308
2017 Pirazzini M, Azarnia Tehran D, Zanetti G, Rossetto O, Montecucco C. Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals. Toxicon : Official Journal of the International Society On Toxinology. PMID 29111118 DOI: 10.1016/J.Toxicon.2017.10.028  0.364
2017 Pirazzini M, Rossetto O, Eleopra R, Montecucco C. Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology. Pharmacological Reviews. 69: 200-235. PMID 28356439 DOI: 10.1124/Pr.116.012658  0.328
2017 Zornetta I, Scorzeto M, Mendes Dos Reis PV, De Lima ME, Montecucco C, Megighian A, Rossetto O. Electrophysiological Characterization of the Antarease Metalloprotease from Tityus serrulatus Venom. Toxins. 9. PMID 28264432 DOI: 10.3390/Toxins9030081  0.354
2017 Rodella U, Negro S, Scorzeto M, Bergamin E, Jalink K, Montecucco C, Yuki N, Rigoni M. Schwann cells are activated by ATP released from neurons in an in vitro cellular model of Miller Fisher syndrome. Disease Models & Mechanisms. PMID 28067631 DOI: 10.1242/Dmm.027870  0.337
2016 Rodella U, Scorzeto M, Duregotti E, Negro S, Dickinson BC, Chang CJ, Yuki N, Rigoni M, Montecucco C. An animal model of Miller Fisher syndrome: Mitochondrial hydrogen peroxide is produced by the autoimmune attack of nerve terminals and activates Schwann cells. Neurobiology of Disease. PMID 27597525 DOI: 10.1016/J.Nbd.2016.09.005  0.369
2016 Zornetta I, Azarnia Tehran D, Arrigoni G, Anniballi F, Bano L, Leka O, Zanotti G, Binz T, Montecucco C. The first non Clostridial botulinum-like toxin cleaves VAMP within the juxtamembrane domain. Scientific Reports. 6: 30257. PMID 27443638 DOI: 10.1038/Srep30257  0.315
2016 Schnell L, Mittler AK, Mattarei A, Azarnia Tehran D, Montecucco C, Barth H. Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells from Intoxication. Toxins. 8. PMID 27428999 DOI: 10.3390/Toxins8070221  0.395
2016 Azarnia Tehran D, Pirazzini M, Leka O, Mattarei A, Lista F, Binz T, Rossetto O, Montecucco C. Hsp90 is involved in the entry of Clostridial Neurotoxins into the Cytosol of Nerve Terminals. Cellular Microbiology. PMID 27404998 DOI: 10.1111/Cmi.12647  0.34
2016 Montecucco C, Zanotti G. Botulinum neurotoxin A1 likes it double sweet. Nature Structural & Molecular Biology. 23: 619-21. PMID 27384187 DOI: 10.1038/Nsmb.3253  0.328
2016 Negro S, Bergamin E, Rodella U, Duregotti E, Scorzeto M, Jalink K, Montecucco C, Rigoni M. ATP Released by Injured Neurons Activates Schwann Cells. Frontiers in Cellular Neuroscience. 10: 134. PMID 27242443 DOI: 10.3389/Fncel.2016.00134  0.343
2016 Schnell L, Mittler AK, Sadi M, Popoff MR, Schwan C, Aktories K, Mattarei A, Azarnia Tehran D, Montecucco C, Barth H. EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin. Toxins. 8: 101. PMID 27043629 DOI: 10.3390/Toxins8040101  0.348
2016 Pirazzini M, Azarnia Tehran D, Leka O, Zanetti G, Rossetto O, Montecucco C. On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments. Biochimica Et Biophysica Acta. 1858: 467-74. PMID 26307528 DOI: 10.1016/J.Bbamem.2015.08.014  0.435
2016 Pirazzini M, Tehran DA, Zanetti G, Leka O, Binz T, Lista F, Mattarei A, Rossetto O, Montecucco C. Hsp90, thioredoxin, and thioredoxin reductase form a chaperone-redox machinery enabling the catalytic activity of clostridial neurotoxins inside nerve terminals Toxicon. 123: S68. DOI: 10.1016/J.Toxicon.2016.11.191  0.302
2015 Azarnia Tehran D, Zanetti G, Leka O, Lista F, Fillo S, Binz T, Shone CC, Rossetto O, Montecucco C, Paradisi C, Mattarei A, Pirazzini M. A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins. Scientific Reports. 5: 17513. PMID 26670952 DOI: 10.1038/Srep17513  0.34
2015 Duregotti E, Zanetti G, Scorzeto M, Megighian A, Montecucco C, Pirazzini M, Rigoni M. Snake and Spider Toxins Induce a Rapid Recovery of Function of Botulinum Neurotoxin Paralysed Neuromuscular Junction. Toxins. 7: 5322-36. PMID 26670253 DOI: 10.3390/Toxins7124887  0.317
2015 Zanetti G, Azarnia Tehran D, Pirazzini M, Binz T, Shone CC, Fillo S, Lista F, Rossetto O, Montecucco C. Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism. Biochemical Pharmacology. 98: 522-30. PMID 26449594 DOI: 10.1016/J.Bcp.2015.09.023  0.377
2015 Rossetto O, Pirazzini M, Montecucco C. Current gaps in basic science knowledge of botulinum neurotoxin biological actions. Toxicon : Official Journal of the International Society On Toxinology. 107: 59-63. PMID 26163315 DOI: 10.1016/J.Toxicon.2015.07.002  0.327
2015 Pirazzini M, Tehran DA, Zanetti G, Lista F, Binz T, Shone CC, Rossetto O, Montecucco C. The thioredoxin reductase - Thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles. Toxicon : Official Journal of the International Society On Toxinology. PMID 26130523 DOI: 10.1016/J.Toxicon.2015.06.019  0.371
2015 Caccin P, Scorzeto M, Damiano N, Marin O, Megighian A, Montecucco C. The synaptotagmin juxtamembrane domain is involved in neuroexocytosis. Febs Open Bio. 5: 388-96. PMID 25973365 DOI: 10.1016/J.Fob.2015.04.013  0.393
2015 Schnell L, Dmochewitz-Kück L, Feigl P, Montecucco C, Barth H. Thioredoxin reductase inhibitor auranofin prevents membrane transport of diphtheria toxin into the cytosol and protects human cells from intoxication. Toxicon : Official Journal of the International Society On Toxinology. PMID 25911959 DOI: 10.1016/J.Toxicon.2015.04.012  0.341
2015 Duregotti E, Negro S, Scorzeto M, Zornetta I, Dickinson BC, Chang CJ, Montecucco C, Rigoni M. Mitochondrial alarmins released by degenerating motor axon terminals activate perisynaptic Schwann cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E497-505. PMID 25605902 DOI: 10.1073/Pnas.1417108112  0.342
2015 Restani L, Bacarella F, Galli-Resta L, Biondi F, Rossetto O, Montecucco C, Caleo M. 166. Mechanisms of action of botulinum neurotoxin type C: an in vivo study Toxicon. 93: S52. DOI: 10.1016/J.Toxicon.2014.11.169  0.672
2014 Mora-Obando D, Fernández J, Montecucco C, Gutiérrez JM, Lomonte B. Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo. Plos One. 9: e109846. PMID 25290688 DOI: 10.1371/Journal.Pone.0109846  0.351
2014 Pirazzini M, Azarnia Tehran D, Zanetti G, Megighian A, Scorzeto M, Fillo S, Shone CC, Binz T, Rossetto O, Lista F, Montecucco C. Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins. Cell Reports. 8: 1870-8. PMID 25220457 DOI: 10.1016/J.Toxicon.2014.11.163  0.405
2014 Rossetto O, Pirazzini M, Montecucco C. Botulinum neurotoxins: genetic, structural and mechanistic insights. Nature Reviews. Microbiology. 12: 535-49. PMID 24975322 DOI: 10.1038/Nrmicro3295  0.376
2014 Pantano S, Montecucco C. The blockade of the neurotransmitter release apparatus by botulinum neurotoxins. Cellular and Molecular Life Sciences : Cmls. 71: 793-811. PMID 23749048 DOI: 10.1007/S00018-013-1380-7  0.374
2013 Pirazzini M, Henke T, Rossetto O, Mahrhold S, Krez N, Rummel A, Montecucco C, Binz T. Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain. Febs Letters. 587: 3831-6. PMID 24157364 DOI: 10.1016/J.Febslet.2013.10.010  0.351
2013 Fernández J, Caccin P, Koster G, Lomonte B, Gutiérrez JM, Montecucco C, Postle AD. Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A₂ myotoxins--distinct mechanisms of action. The Febs Journal. 280: 3878-86. PMID 23763831 DOI: 10.1111/Febs.12386  0.336
2013 Megighian A, Zordan M, Pantano S, Scorzeto M, Rigoni M, Zanini D, Rossetto O, Montecucco C. Evidence for a radial SNARE super-complex mediating neurotransmitter release at the Drosophila neuromuscular junction. Journal of Cell Science. 126: 3134-40. PMID 23687382 DOI: 10.1242/Jcs.123802  0.312
2013 Colasante C, Rossetto O, Morbiato L, Pirazzini M, Molgó J, Montecucco C. Botulinum neurotoxin type A is internalized and translocated from small synaptic vesicles at the neuromuscular junction. Molecular Neurobiology. 48: 120-7. PMID 23471747 DOI: 10.1007/S12035-013-8423-9  0.394
2013 Silva DS, Pereira LM, Moreira AR, Ferreira-da-Silva F, Brito RM, Faria TQ, Zornetta I, Montecucco C, Oliveira P, Azevedo JE, Pereira PJ, Macedo-Ribeiro S, do Vale A, dos Santos NM. The apoptogenic toxin AIP56 is a metalloprotease A-B toxin that cleaves NF-κb P65. Plos Pathogens. 9: e1003128. PMID 23468618 DOI: 10.1371/Journal.Ppat.1003128  0.335
2013 Duregotti E, Tedesco E, Montecucco C, Rigoni M. Calpains participate in nerve terminal degeneration induced by spider and snake presynaptic neurotoxins. Toxicon : Official Journal of the International Society On Toxinology. 64: 20-8. PMID 23266309 DOI: 10.1016/J.Toxicon.2012.12.007  0.371
2013 Eleopra R, Montecucco C, Devigili G, Lettieri C, Rinaldo S, Verriello L, Pirazzini M, Caccin P, Rossetto O. Botulinum neurotoxin serotype D is poorly effective in humans: an in vivo electrophysiological study. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 124: 999-1004. PMID 23245668 DOI: 10.1016/J.Clinph.2012.11.004  0.344
2013 Pirazzini M, Rossetto O, Bertasio C, Bordin F, Shone CC, Binz T, Montecucco C. Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons. Biochemical and Biophysical Research Communications. 430: 38-42. PMID 23200837 DOI: 10.1016/J.Bbrc.2012.11.048  0.354
2013 Pirazzini M, Bordin F, Rossetto O, Shone CC, Binz T, Montecucco C. The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals. Febs Letters. 587: 150-5. PMID 23178719 DOI: 10.1016/J.Febslet.2012.11.007  0.398
2013 Pirazzini M, Rossetto O, Bordin F, Shone C, Binz T, Montecucco C. Membrane translocation of tetanus and botulinum neurotoxins Toxicon. 75: 209. DOI: 10.1016/J.Toxicon.2013.08.014  0.327
2013 Colasante C, Morbiato L, Paoli M, Shone C, Muraro L, Sheikh K, Rossetto O, Montecucco C, Molgó J. Peripheral cholinergic specificity of botulinum type A neurotoxin Toxicon. 68: 70-71. DOI: 10.1016/J.Toxicon.2012.07.045  0.703
2013 Montecucco C, Megighian A, Pantano S, Rigoni M, Rossetto O, Schiavo G, Scorzeto M, Zanini D, Zordan M. Botulinum neurotoxins and the neuroexocytosis nanomachine Toxicon. 68: 62-63. DOI: 10.1016/J.Toxicon.2012.07.025  0.519
2012 Tonello F, Simonato M, Aita A, Pizzo P, Fernández J, Lomonte B, Gutiérrez JM, Montecucco C. A Lys49-PLA2 myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling. Cell Death & Disease. 3: e343. PMID 22764102 DOI: 10.1038/Cddis.2012.68  0.335
2011 Pirazzini M, Rossetto O, Bolognese P, Shone CC, Montecucco C. Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons. Cellular Microbiology. 13: 1731-43. PMID 21790947 DOI: 10.1016/J.Toxicon.2012.07.099  0.411
2010 Megighian A, Scorzeto M, Zanini D, Pantano S, Rigoni M, Benna C, Rossetto O, Montecucco C, Zordan M. Arg206 of SNAP-25 is essential for neuroexocytosis at the Drosophila melanogaster neuromuscular junction. Journal of Cell Science. 123: 3276-83. PMID 20826463 DOI: 10.1242/Jcs.071316  0.381
2010 Davletov B, Montecucco C. Lipid function at synapses. Current Opinion in Neurobiology. 20: 543-9. PMID 20655194 DOI: 10.1016/J.Conb.2010.06.008  0.363
2010 Zornetta I, Brandi L, Janowiak B, Dal Molin F, Tonello F, Collier RJ, Montecucco C. Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras. Cellular Microbiology. 12: 1435-45. PMID 20438574 DOI: 10.1111/J.1462-5822.2010.01480.X  0.347
2010 Cintra-Francischinelli M, Pizzo P, Angulo Y, Gutiérrez JM, Montecucco C, Lomonte B. The C-terminal region of a Lys49 myotoxin mediates Ca2+ influx in C2C12 myotubes. Toxicon : Official Journal of the International Society On Toxinology. 55: 590-6. PMID 19835905 DOI: 10.1016/J.Toxicon.2009.10.013  0.313
2009 Paoli M, Rigoni M, Koster G, Rossetto O, Montecucco C, Postle AD. Mass spectrometry analysis of the phospholipase A(2) activity of snake pre-synaptic neurotoxins in cultured neurons. Journal of Neurochemistry. 111: 737-44. PMID 19712054 DOI: 10.1111/J.1471-4159.2009.06365.X  0.748
2009 Tonello F, Montecucco C. The anthrax lethal factor and its MAPK kinase-specific metalloprotease activity. Molecular Aspects of Medicine. 30: 431-8. PMID 19665472 DOI: 10.1016/J.Mam.2009.07.006  0.326
2009 Fogolari F, Tosatto SC, Muraro L, Montecucco C. Electric dipole reorientation in the interaction of botulinum neurotoxins with neuronal membranes. Febs Letters. 583: 2321-5. PMID 19576894 DOI: 10.1016/J.Febslet.2009.06.046  0.373
2009 Cintra-Francischinelli M, Pizzo P, Rodrigues-Simioni L, Ponce-Soto LA, Rossetto O, Lomonte B, Gutiérrez JM, Pozzan T, Montecucco C. Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors. Cellular and Molecular Life Sciences : Cmls. 66: 1718-28. PMID 19370311 DOI: 10.1007/S00018-009-9053-2  0.307
2009 Tedesco E, Rigoni M, Caccin P, Grishin E, Rossetto O, Montecucco C. Calcium overload in nerve terminals of cultured neurons intoxicated by alpha-latrotoxin and snake PLA2 neurotoxins. Toxicon : Official Journal of the International Society On Toxinology. 54: 138-44. PMID 19341756 DOI: 10.1016/J.Toxicon.2009.03.025  0.366
2009 Muraro L, Tosatto S, Motterlini L, Rossetto O, Montecucco C. The N-terminal half of the receptor domain of botulinum neurotoxin A binds to microdomains of the plasma membrane. Biochemical and Biophysical Research Communications. 380: 76-80. PMID 19161982 DOI: 10.1016/J.Bbrc.2009.01.037  0.393
2009 Caccin P, Rossetto O, Montecucco C. Neurotoxicity of inverted-cone shaped lipids. Neurotoxicology. 30: 174-81. PMID 19114055 DOI: 10.1016/J.Neuro.2008.11.013  0.353
2009 Montecucco C, Rossetto O, Caccin P, Rigoni M, Carli L, Morbiato L, Muraro L, Paoli M. Different mechanisms of inhibition of nerve terminals by botulinum and snake presynaptic neurotoxins. Toxicon : Official Journal of the International Society On Toxinology. 54: 561-4. PMID 19111566 DOI: 10.1016/J.Toxicon.2008.12.012  0.735
2008 Rigoni M, Paoli M, Milanesi E, Caccin P, Rasola A, Bernardi P, Montecucco C. Snake phospholipase A2 neurotoxins enter neurons, bind specifically to mitochondria, and open their transition pores. The Journal of Biological Chemistry. 283: 34013-20. PMID 18809685 DOI: 10.1074/Jbc.M803243200  0.741
2008 Dal Molin F, Zornetta I, Puhar A, Tonello F, Zaccolo M, Montecucco C. cAMP imaging of cells treated with pertussis toxin, cholera toxin, and anthrax edema toxin. Biochemical and Biophysical Research Communications. 376: 429-33. PMID 18793614 DOI: 10.1016/J.Bbrc.2008.09.012  0.309
2008 Johnson EA, Montecucco C. Chapter 11 Botulism Handbook of Clinical Neurology. 91: 333-368. PMID 18631849 DOI: 10.1016/S0072-9752(07)01511-4  0.353
2008 Montecucco C, Gutiérrez JM, Lomonte B. Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action. Cellular and Molecular Life Sciences. 65: 2897-2912. PMID 18563294 DOI: 10.1007/S00018-008-8113-3  0.367
2008 Paccani SR, Dal Molin F, Benagiano M, Ladant D, D'Elios MM, Montecucco C, Baldari CT. Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussis. Infection and Immunity. 76: 2822-32. PMID 18426886 DOI: 10.1128/Iai.00200-08  0.319
2008 Rossetto O, Montecucco C. Presynaptic neurotoxins with enzymatic activities. Handbook of Experimental Pharmacology. 129-70. PMID 18064414 DOI: 10.1007/978-3-540-74805-2_6  0.355
2008 Rossetto O, Morbiato L, Caccin P, Rigoni M, Carli L, Paoli M, Cintra-Francischelli M, Montecucco C. Tetanus, botulinum and snake presynaptic neurotoxins Rendiconti Lincei. 19: 173-188. DOI: 10.1007/S12210-008-0010-Z  0.709
2007 Puhar A, Montecucco C. Where and how do anthrax toxins exit endosomes to intoxicate host cells? Trends in Microbiology. 15: 477-82. PMID 17983750 DOI: 10.1016/J.Tim.2007.10.003  0.317
2007 Caleo M, Restani L, Gianfranceschi L, Costantin L, Rossi C, Rossetto O, Montecucco C, Maffei L. Transient synaptic silencing of developing striate cortex has persistent effects on visual function and plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4530-40. PMID 17460066 DOI: 10.1523/Jneurosci.0772-07.2007  0.667
2007 Giner D, López I, Neco P, Rossetto O, Montecucco C, Gutiérrez LM. Glycogen synthase kinase 3 activation is essential for the snake phospholipase A2 neurotoxin-induced secretion in chromaffin cells. The European Journal of Neuroscience. 25: 2341-8. PMID 17445232 DOI: 10.1111/J.1460-9568.2007.05497.X  0.356
2007 Rossetto O, Montecucco C. Peculiar binding of botulinum neurotoxins. Acs Chemical Biology. 2: 96-8. PMID 17313178 DOI: 10.1021/Cb700020V  0.376
2007 Rigoni M, Pizzo P, Schiavo G, Weston AE, Zatti G, Caccin P, Rossetto O, Pozzan T, Montecucco C. Calcium influx and mitochondrial alterations at synapses exposed to snake neurotoxins or their phospholipid hydrolysis products. The Journal of Biological Chemistry. 282: 11238-45. PMID 17311918 DOI: 10.1074/Jbc.M610176200  0.587
2007 Megighian A, Rigoni M, Caccin P, Zordan MA, Montecucco C. A lysolecithin/fatty acid mixture promotes and then blocks neurotransmitter release at the Drosophila melanogaster larval neuromuscular junction. Neuroscience Letters. 416: 6-11. PMID 17293048 DOI: 10.1016/J.Neulet.2007.01.040  0.366
2007 Genisset C, Puhar A, Calore F, de Bernard M, Dell'Antone P, Montecucco C. The concerted action of the Helicobacter pylori cytotoxin VacA and of the v-ATPase proton pump induces swelling of isolated endosomes. Cellular Microbiology. 9: 1481-90. PMID 17253977 DOI: 10.1111/J.1462-5822.2006.00886.X  0.301
2007 Verderio C, Grumelli C, Raiteri L, Coco S, Paluzzi S, Caccin P, Rossetto O, Bonanno G, Montecucco C, Matteoli M. Traffic of botulinum toxins A and E in excitatory and inhibitory neurons. Traffic (Copenhagen, Denmark). 8: 142-53. PMID 17241445 DOI: 10.1111/J.1600-0854.2006.00520.X  0.364
2007 Polenghi A, Bossi F, Fischetti F, Durigutto P, Cabrelle A, Tamassia N, Cassatella MA, Montecucco C, Tedesco F, de Bernard M. The neutrophil-activating protein of Helicobacter pylori crosses endothelia to promote neutrophil adhesion in vivo. Journal of Immunology (Baltimore, Md. : 1950). 178: 1312-20. PMID 17237377 DOI: 10.4049/Jimmunol.178.3.1312  0.302
2006 Dal Molin F, Tonello F, Ladant D, Zornetta I, Zamparo I, Di Benedetto G, Zaccolo M, Montecucco C. Cell entry and cAMP imaging of anthrax edema toxin. The Embo Journal. 25: 5405-13. PMID 17082768 DOI: 10.1038/Sj.Emboj.7601408  0.331
2006 Verderio C, Rossetto O, Grumelli C, Frassoni C, Montecucco C, Matteoli M. Entering neurons: botulinum toxins and synaptic vesicle recycling. Embo Reports. 7: 995-9. PMID 17016457 DOI: 10.1038/Sj.Embor.7400796  0.406
2006 Baldari CT, Tonello F, Paccani SR, Montecucco C. Anthrax toxins: A paradigm of bacterial immune suppression. Trends in Immunology. 27: 434-40. PMID 16861036 DOI: 10.1016/J.It.2006.07.002  0.308
2006 Rossetto O, Morbiato L, Caccin P, Rigoni M, Montecucco C. Presynaptic enzymatic neurotoxins. Journal of Neurochemistry. 97: 1534-45. PMID 16805767 DOI: 10.1111/J.1471-4159.2006.03965.X  0.393
2006 Couturier MR, Tasca E, Montecucco C, Stein M. Interaction with CagF is required for translocation of CagA into the host via the Helicobacter pylori type IV secretion system. Infection and Immunity. 74: 273-81. PMID 16368981 DOI: 10.1128/Iai.74.1.273-281.2006  0.345
2006 Pantano S, Montecucco C. A molecular model of the Vibrio cholerae cytolysin transmembrane pore. Toxicon : Official Journal of the International Society On Toxinology. 47: 35-40. PMID 16330061 DOI: 10.1016/J.Toxicon.2005.09.007  0.306
2005 Rigoni M, Caccin P, Gschmeissner S, Koster G, Postle AD, Rossetto O, Schiavo G, Montecucco C. Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid mixtures. Science (New York, N.Y.). 310: 1678-80. PMID 16339444 DOI: 10.1126/Science.1120640  0.568
2005 Romanello V, Marcacci M, Dal Molin F, Moschioni M, Censini S, Covacci A, Baritussio AG, Montecucco C, Tonello F. Cloning, expression, purification, and characterization of Streptococcus pneumoniae IgA1 protease. Protein Expression and Purification. 45: 142-9. PMID 16146695 DOI: 10.1016/J.Pep.2005.07.015  0.364
2005 Tugnoli V, Eleopra R, Montecucco C, De Grandis D. The therapeutic use of botulinum toxin. Expert Opinion On Investigational Drugs. 6: 1383-94. PMID 15989508 DOI: 10.1517/13543784.6.10.1383  0.354
2005 Montecucco C, Schiavo G, Pantano S. SNARE complexes and neuroexocytosis: how many, how close? Trends in Biochemical Sciences. 30: 367-72. PMID 15935678 DOI: 10.1016/J.Tibs.2005.05.002  0.536
2005 Grumelli C, Verderio C, Pozzi D, Rossetto O, Montecucco C, Matteoli M. Internalization and mechanism of action of clostridial toxins in neurons. Neurotoxicology. 26: 761-7. PMID 15925409 DOI: 10.1016/J.Neuro.2004.12.012  0.407
2005 Montecucco C, Molgó J. Botulinal neurotoxins: revival of an old killer. Current Opinion in Pharmacology. 5: 274-9. PMID 15907915 DOI: 10.1016/J.Coph.2004.12.006  0.352
2005 Paccani SR, Tonello F, Ghittoni R, Natale M, Muraro L, D'Elios MM, Tang WJ, Montecucco C, Baldari CT. Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling. The Journal of Experimental Medicine. 201: 325-31. PMID 15699068 DOI: 10.1084/Jem.20041557  0.3
2005 Bonanomi D, Pennuto M, Rigoni M, Rossetto O, Montecucco C, Valtorta F. Taipoxin induces synaptic vesicle exocytosis and disrupts the interaction of synaptophysin I with VAMP2. Molecular Pharmacology. 67: 1901-8. PMID 15695624 DOI: 10.1124/Mol.104.005678  0.374
2004 Montecucco C, Rossetto O, Schiavo G. Presynaptic receptor arrays for clostridial neurotoxins. Trends in Microbiology. 12: 442-6. PMID 15381192 DOI: 10.1016/J.Tim.2004.08.002  0.573
2004 Montecucco C, Tonello F, Zanotti G. Stop the killer: how to inhibit the anthrax lethal factor metalloprotease. Trends in Biochemical Sciences. 29: 282-5. PMID 15276179 DOI: 10.1016/J.Tibs.2004.04.011  0.326
2004 Rigoni M, Schiavo G, Weston AE, Caccin P, Allegrini F, Pennuto M, Valtorta F, Montecucco C, Rossetto O. Snake presynaptic neurotoxins with phospholipase A2 activity induce punctate swellings of neurites and exocytosis of synaptic vesicles. Journal of Cell Science. 117: 3561-70. PMID 15226375 DOI: 10.1242/Jcs.01218  0.593
2004 Puhar A, Johnson EA, Rossetto O, Montecucco C. Comparison of the pH-induced conformational change of different clostridial neurotoxins. Biochemical and Biophysical Research Communications. 319: 66-71. PMID 15158443 DOI: 10.1016/J.Bbrc.2004.04.140  0.329
2004 Rossetto O, Rigoni M, Montecucco C. Different mechanism of blockade of neuroexocytosis by presynaptic neurotoxins. Toxicology Letters. 149: 91-101. PMID 15093253 DOI: 10.1016/J.Toxlet.2003.12.023  0.38
2004 Tonello F, Naletto L, Romanello V, Dal Molin F, Montecucco C. Tyrosine-728 and glutamic acid-735 are essential for the metalloproteolytic activity of the lethal factor of Bacillus anthracis. Biochemical and Biophysical Research Communications. 313: 496-502. PMID 14697216 DOI: 10.1016/J.Bbrc.2003.11.134  0.303
2003 Tonello F, Ascenzi P, Montecucco C. The metalloproteolytic activity of the anthrax lethal factor is substrate-inhibited. The Journal of Biological Chemistry. 278: 40075-8. PMID 12888555 DOI: 10.1074/Jbc.M306466200  0.315
2003 Montecucco C, de Bernard M. Molecular and cellular mechanisms of action of the vacuolating cytotoxin (VacA) and neutrophil-activating protein (HP-NAP) virulence factors of Helicobacter pylori. Microbes and Infection. 5: 715-21. PMID 12814772 DOI: 10.1016/S1286-4579(03)00124-2  0.307
2003 Caccin P, Rossetto O, Rigoni M, Johnson E, Schiavo G, Montecucco C. VAMP/synaptobrevin cleavage by tetanus and botulinum neurotoxins is strongly enhanced by acidic liposomes. Febs Letters. 542: 132-6. PMID 12729912 DOI: 10.1016/S0014-5793(03)00365-X  0.61
2003 Neco P, Rossetto O, Gil A, Montecucco C, Gutiérrez LM. Taipoxin induces F-actin fragmentation and enhances release of catecholamines in bovine chromaffin cells. Journal of Neurochemistry. 85: 329-37. PMID 12675909 DOI: 10.1046/J.1471-4159.2003.01682.X  0.339
2003 Rossetto O, Seveso M, Caccin P, Montecucco C. Botulinum neurotoxins are metalloproteases specific for SNARE proteins involved in neuroexocytosis. Current Problems in Dermatology. 30: 117-25. PMID 12471705 DOI: 10.1159/000060684  0.324
2002 Ascenzi P, Visca P, Ippolito G, Spallarossa A, Bolognesi M, Montecucco C. Anthrax toxin: a tripartite lethal combination. Febs Letters. 531: 384-8. PMID 12435580 DOI: 10.1016/S0014-5793(02)03609-8  0.335
2002 Seydel A, Tasca E, Berti D, Rappuoli R, Del Giudice G, Montecucco C. Characterization and immunogenicity of the CagF protein of the cag pathogenicity island of Helicobacter pylori. Infection and Immunity. 70: 6468-70. PMID 12379730 DOI: 10.1128/Iai.70.11.6468-6470.2002  0.305
2002 Dundon WG, Nishioka H, Polenghi A, Papinutto E, Zanotti G, Montemurro P, Del GG, Rappuoli R, Montecucco C. The neutrophil-activating protein of Helicobacter pylori. International Journal of Medical Microbiology : Ijmm. 291: 545-50. PMID 11890556 DOI: 10.1078/1438-4221-00165  0.329
2002 De Bernard M, Moschioni M, Habermann A, Griffiths G, Montecucco C. Cell vacuolization induced by Helicobacter pylori VacA cytotoxin does not depend on late endosomal SNAREs Cellular Microbiology. 4: 11-18. PMID 11856169 DOI: 10.1046/J.1462-5822.2002.00163.X  0.376
2002 Papinutto E, Dundon WG, Pitulis N, Battistutta R, Montecucco C, Zanotti G. Structure of two iron-binding proteins from Bacillus anthracis. The Journal of Biological Chemistry. 277: 15093-8. PMID 11836250 DOI: 10.1074/Jbc.M112378200  0.308
2002 Dundon W, Nishioka H, Montecucco C, Montemurro P, Rappuoli R, del Giudice G. Problems in identifying microbial-derived neutrophil activators, focusing on Helicobacter pylori Trends in Microbiology. 10: 14. DOI: 10.1016/S0966-842X(01)02280-6  0.331
2002 Bernard M, Rossetto O, Montecucco C. 16 Bacterial toxins: Intracellular trafficking and target identification Methods in Microbiology. 31: 297-317. DOI: 10.1016/S0580-9517(02)31017-1  0.394
2001 Tombola F, Pagliaccia C, Campello S, Telford JL, Montecucco C, Papini E, Zoratti M. How the loop and middle regions influence the properties of Helicobacter pylori VacA channels. Biophysical Journal. 81: 3204-15. PMID 11720986 DOI: 10.1016/S0006-3495(01)75956-5  0.308
2001 Rigoni M, Caccin P, Johnson EA, Montecucco C, Rossetto O. Site-directed mutagenesis identifies active-site residues of the light chain of botulinum neurotoxin type A. Biochemical and Biophysical Research Communications. 288: 1231-7. PMID 11700044 DOI: 10.1006/Bbrc.2001.5911  0.328
2001 Montecucco C. Detoxification of a bacterial toxin by the toxin itself. Trends in Pharmacological Sciences. 22: 493-4. PMID 11583789 DOI: 10.1016/S0165-6147(00)01808-3  0.328
2001 Dundon WG, de Bernard M, Montecucco C. Virulence factors of Helicobacter pylori. International Journal of Medical Microbiology : Ijmm. 290: 647-58. PMID 11310443 DOI: 10.1016/S1438-4221(01)80002-3  0.319
2001 Rossetto O, Caccin P, Rigoni M, Tonello F, Bortoletto N, Stevens RC, Montecucco C. Active-site mutagenesis of tetanus neurotoxin implicates TYR-375 and GLU-271 in metalloproteolytic activity. Toxicon : Official Journal of the International Society On Toxinology. 39: 1151-9. PMID 11306125 DOI: 10.1016/S0041-0101(00)00252-X  0.365
2001 Montemurro P, Barbuti G, Dundon WG, Del Giudice G, Rappuoli R, Colucci M, De Rinaldis P, Montecucco C, Semeraro N, Papini E. Helicobacter pylori neutrophil-activating protein stimulates tissue factor and plasminogen activator inhibitor-2 production by human blood mononuclear cells. The Journal of Infectious Diseases. 183: 1055-62. PMID 11237830 DOI: 10.1086/319280  0.302
2001 Pellizzari R, Guidi-Rontani C, Vitale G, Mock M, Montecucco C. Lethal factor of Bacillus anthracis cleaves the N-terminus of MAPKKs: analysis of the intracellular consequences in macrophages. International Journal of Medical Microbiology : Ijmm. 290: 421-7. PMID 11111921 DOI: 10.1016/S1438-4221(00)80056-9  0.327
2001 Rossetto O, Seveso M, Caccin P, Schiavo G, Montecucco C. Tetanus and botulinum neurotoxins: turning bad guys into good by research. Toxicon : Official Journal of the International Society On Toxinology. 39: 27-41. PMID 10936621 DOI: 10.1016/S0041-0101(00)00163-X  0.621
2000 Montecucco C, Rossetto O. How do presynaptic PLA2 neurotoxins block nerve terminals? Trends in Biochemical Sciences. 25: 266-70. PMID 10838563 DOI: 10.1016/S0968-0004(00)01556-5  0.389
2000 Herreros J, Lalli G, Montecucco C, Schiavo G. Tetanus toxin fragment C binds to a protein present in neuronal cell lines and motoneurons. Journal of Neurochemistry. 74: 1941-50. PMID 10800937 DOI: 10.1046/J.1471-4159.2000.0741941.X  0.777
2000 Satin B, Del Giudice G, Della Bianca V, Dusi S, Laudanna C, Tonello F, Kelleher D, Rappuoli R, Montecucco C, Rossi F. The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor. The Journal of Experimental Medicine. 191: 1467-76. PMID 10790422 DOI: 10.1084/Jem.191.9.1467  0.309
2000 Schiavo G, Matteoli M, Montecucco C. Neurotoxins affecting neuroexocytosis. Physiological Reviews. 80: 717-66. PMID 10747206 DOI: 10.1152/Physrev.2000.80.2.717  0.591
2000 Rossetto O, de Bernard M, Pellizzari R, Vitale G, Caccin P, Schiavo G, Montecucco C. Bacterial toxins with intracellular protease activity. Clinica Chimica Acta; International Journal of Clinical Chemistry. 291: 189-99. PMID 10675723 DOI: 10.1016/S0009-8981(99)00228-4  0.61
2000 de Bernard M, Moschioni M, Napolitani G, Rappuoli R, Montecucco C. The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein. The Embo Journal. 19: 48-56. PMID 10619843 DOI: 10.1093/Emboj/19.1.48  0.338
2000 Tonello F, Dundon WG, Satin B, Molinari M, Tognon G, Grandi G, Del Giudice G, Rappuoli R, Montecucco C. The Helicobacter pylori neutrophil-activating protein is an iron-binding protein with dodecameric structure. Molecular Microbiology. 34: 238-46. PMID 10564468 DOI: 10.1046/J.1365-2958.1999.01584.X  0.31
2000 Reyrat JM, Pelicic V, Papini E, Montecucco C, Rappuoli R, Telford JL. Towards deciphering the Helicobacter pylori cytotoxin. Molecular Microbiology. 34: 197-204. PMID 10564464 DOI: 10.1046/J.1365-2958.1999.01592.X  0.317
1999 Washbourne P, Bortoletto N, Graham ME, Wilson MC, Burgoyne RD, Montecucco C. Botulinum neurotoxin E-insensitive mutants of SNAP-25 fail to bind VAMP but support exocytosis. Journal of Neurochemistry. 73: 2424-33. PMID 10582602 DOI: 10.1046/J.1471-4159.1999.0732424.X  0.399
1999 Szabò I, Brutsche S, Tombola F, Moschioni M, Satin B, Telford JL, Rappuoli R, Montecucco C, Papini E, Zoratti M. Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity. The Embo Journal. 18: 5517-27. PMID 10523296 DOI: 10.1093/Emboj/18.20.5517  0.336
1999 Pelicic V, Reyrat JM, Sartori L, Pagliaccia C, Rappuoli R, Telford JL, Montecucco C, Papini E. Helicobacter pylori VacA cytotoxin associated with the bacteria increases epithelial permeability independently of its vacuolating activity. Microbiology (Reading, England). 2043-2050. PMID 10463170 DOI: 10.1099/13500872-145-8-2043  0.31
1999 Verderio C, Coco S, Rossetto O, Montecucco C, Matteoli M. Internalization and proteolytic action of botulinum toxins in CNS neurons and astrocytes. Journal of Neurochemistry. 73: 372-9. PMID 10386990 DOI: 10.1046/J.1471-4159.1999.0730372.X  0.366
1999 Montecucco C, Papini E, de Bernard M, Zoratti M. Molecular and cellular activities of Helicobacter pylori pathogenic factors. Febs Letters. 452: 16-21. PMID 10376670 DOI: 10.1016/S0014-5793(99)00652-3  0.323
1999 Pellizzari R, Rossetto O, Schiavo G, Montecucco C. Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 354: 259-68. PMID 10212474 DOI: 10.1098/Rstb.1999.0377  0.627
1999 Tombola F, Carlesso C, Szabò I, de Bernard M, Reyrat JM, Telford JL, Rappuoli R, Montecucco C, Papini E, Zoratti M. Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: possible implications for the mechanism of cellular vacuolation. Biophysical Journal. 76: 1401-9. PMID 10049322 DOI: 10.1016/S0006-3495(99)77301-7  0.328
1999 Verderio C, Coco S, Bacci A, Rossetto O, De Camilli P, Montecucco C, Matteoli M. Tetanus Toxin Blocks the Exocytosis of Synaptic Vesicles Clustered at Synapses But Not of Synaptic Vesicles in Isolated Axons The Journal of Neuroscience. 19: 6723-6732. DOI: 10.1523/Jneurosci.19-16-06723.1999  0.333
1998 Pellizzari R, Rossetto O, Washbourne P, Tonello F, Nicotera PL, Montecucco C. In vitro biological activity and toxicity of tetanus and botulinum neurotoxins. Toxicology Letters. 102: 191-7. PMID 10022253 DOI: 10.1016/S0378-4274(98)00306-3  0.349
1998 de Bernard M, Burroni D, Papini E, Rappuoli R, Telford J, Montecucco C. Identification of the Helicobacter pylori VacA toxin domain active in the cell cytosol. Infection and Immunity. 66: 6014-6. PMID 9826387 DOI: 10.1128/Iai.66.12.6014-6016.1998  0.351
1998 de Bernard M, Moschioni M, Papini E, Telford J, Rappuoli R, Montecucco C. Cell vacuolization induced by Helicobacter pylori VacA toxin: cell line sensitivity and quantitative estimation. Toxicology Letters. 99: 109-15. PMID 9817082 DOI: 10.1016/S0378-4274(98)00140-4  0.333
1998 Washbourne P, Pellizzari R, Rossetto O, Bortoletto N, Tugnoli V, De Grandis D, Eleopra R, Montecucco C. On the action of botulinum neurotoxins A and E at cholinergic terminals. Journal of Physiology, Paris. 92: 135-9. PMID 9782457 DOI: 10.1016/S0928-4257(98)80151-4  0.349
1998 de Bernard M, Moschioni M, Papini E, Telford JL, Rappuoli R, Montecucco C. TPA and butyrate increase cell sensitivity to the vacuolating toxin of Helicobacter pylori. Febs Letters. 436: 218-22. PMID 9781682 DOI: 10.1016/S0014-5793(98)01132-6  0.37
1998 Montecucco C. Protein toxins and membrane transport. Current Opinion in Cell Biology. 10: 530-6. PMID 9719875 DOI: 10.1016/S0955-0674(98)80069-0  0.368
1998 Vitale G, Pellizzari R, Recchi C, Napolitani G, Mock M, Montecucco C. Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages. Biochemical and Biophysical Research Communications. 248: 706-11. PMID 9703991 DOI: 10.1046/J.1365-2672.1999.00893.X  0.3
1998 Benjelloun-Touimi Z, Si Tahar M, Montecucco C, Sansonetti PJ, Parsot C. SepA, the 110 kDa protein secreted by Shigella flexneri: two-domain structure and proteolytic activity. Microbiology (Reading, England). 1815-22. PMID 9695914 DOI: 10.1099/00221287-144-7-1815  0.342
1998 Molinari M, Galli C, de Bernard M, Norais N, Ruysschaert JM, Rappuoli R, Montecucco C. The acid activation of Helicobacter pylori toxin VacA: structural and membrane binding studies. Biochemical and Biophysical Research Communications. 248: 334-40. PMID 9675136 DOI: 10.1006/Bbrc.1998.8808  0.391
1998 de Bernard M, Arico B, Papini E, Rizzuto R, Grandi G, Rappuoli R, Montecucco C. Helicobacter pylori toxin VacA induces vacuole formation by acting in the cell cytosol. Molecular Microbiology. 26: 665-74. PMID 9427397 DOI: 10.1046/J.1365-2958.1997.5881952.X  0.387
1998 Molinari M, Salio M, Galli C, Norais N, Rappuoli R, Lanzavecchia A, Montecucco C. Selective Inhibition of Ii-dependent Antigen Presentation by Helicobacter pylori Toxin VacA Journal of Experimental Medicine. 187: 135-140. PMID 9419220 DOI: 10.1084/Jem.187.1.135  0.301
1998 Montecucco C, Pellizzari R, Rossetto O, Schiavo G, Tonello F. Mechanism of action of clostridial neurotoxins Toxicology Letters. 95: 10. DOI: 10.1016/S0378-4274(98)80038-6  0.496
1997 Washbourne P, Pellizzari R, Baldini G, Wilson MC, Montecucco C. Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis. Febs Letters. 418: 1-5. PMID 9414082 DOI: 10.1016/S0014-5793(97)01328-8  0.356
1997 Satin B, Norais N, Telford J, Rappuoli R, Murgia M, Montecucco C, Papini E. Effect of helicobacter pylori vacuolating toxin on maturation and extracellular release of procathepsin D and on epidermal growth factor degradation. The Journal of Biological Chemistry. 272: 25022-8. PMID 9312109 DOI: 10.1074/Jbc.272.40.25022  0.333
1997 Tonello F, Schiavo G, Montecucco C. Metal substitution of tetanus neurotoxin. The Biochemical Journal. 507-10. PMID 9065770 DOI: 10.1042/Bj3220507  0.521
1997 Papini E, Satin B, Bucci C, de Bernard M, Telford JL, Manetti R, Rappuoli R, Zerial M, Montecucco C. The small GTP binding protein rab7 is essential for cellular vacuolation induced by Helicobacter pylori cytotoxin. The Embo Journal. 16: 15-24. PMID 9009263 DOI: 10.1093/Emboj/16.1.15  0.354
1997 Montecucco C, Papini E, Schiavo G. Bacterial protein toxins and cell vesicle trafficking. Experientia. 52: 1026-32. PMID 8988242 DOI: 10.1007/Bf01952098  0.601
1997 Montecucco C, Schiavo G, Tugnoli V, de Grandis D. Botulinum neurotoxins: mechanism of action and therapeutic applications. Molecular Medicine Today. 2: 418-24. PMID 8897436 DOI: 10.1016/1357-4310(96)84845-3  0.551
1996 Matteoli M, Verderio C, Rossetto O, Iezzi N, Coco S, Schiavo G, Montecucco C. Synaptic vesicle endocytosis mediates the entry of tetanus neurotoxin into hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 93: 13310-5. PMID 8917587 DOI: 10.1073/Pnas.93.23.13310  0.577
1996 Montecucco C, Schiavo G. Structure and function of tetanus and botulinum neurotoxins. Quarterly Reviews of Biophysics. 28: 423-72. PMID 8771234 DOI: 10.1017/S0033583500003292  0.645
1996 Osen-Sand A, Staple JK, Naldi E, Schiavo G, Rossetto O, Petitpierre S, Malgaroli A, Montecucco C, Catsicas S. Common and distinct fusion proteins in axonal growth and transmitter release. The Journal of Comparative Neurology. 367: 222-34. PMID 8708006 DOI: 10.1002/(Sici)1096-9861(19960401)367:2<222::Aid-Cne5>3.0.Co;2-7  0.592
1996 Pellizzari R, Rossetto O, Lozzi L, Giovedi' S, Johnson E, Shone CC, Montecucco C. Structural determinants of the specificity for synaptic vesicle-associated membrane protein/synaptobrevin of tetanus and botulinum type B and G neurotoxins. The Journal of Biological Chemistry. 271: 20353-8. PMID 8702770 DOI: 10.1074/Jbc.271.34.20353  0.419
1996 Morante S, Furenlid L, Schiavo G, Tonello F, Zwilling R, Montecucco C. X-ray absorption spectroscopy study of zinc coordination in tetanus neurotoxin, astacin, alkaline protease and thermolysin. European Journal of Biochemistry. 235: 606-12. PMID 8654408 DOI: 10.1111/J.1432-1033.1996.00606.X  0.501
1996 Ménard A, Altendorf K, Breves D, Mock M, Montecucco C. The vacuolar ATPase proton pump is required for the cytotoxicity of Bacillus anthracis lethal toxin. Febs Letters. 386: 161-4. PMID 8647272 DOI: 10.1016/0014-5793(96)00422-X  0.324
1996 Wictome M, Rossetto O, Montecucco C, Shone CC. Substrate residues N-terminal to the cleavage site of botulinum type B neurotoxin play a role in determining the specificity of its endopeptidase activity. Febs Letters. 386: 133-6. PMID 8647267 DOI: 10.1016/0014-5793(96)00431-0  0.358
1996 Williamson LC, Halpern JL, Montecucco C, Brown JE, Neale EA. Clostridial neurotoxins and substrate proteolysis in intact neurons: botulinum neurotoxin C acts on synaptosomal-associated protein of 25 kDa. The Journal of Biological Chemistry. 271: 7694-9. PMID 8631808 DOI: 10.1074/Jbc.271.13.7694  0.417
1996 Moll G, Papini E, Colonna R, Burroni D, Telford J, Rappuoli R, Montecucco C. Lipid interaction of the 37-kDa and 58-kDa fragments of the Helicobacter pylori cytotoxin. European Journal of Biochemistry. 234: 947-52. PMID 8575456 DOI: 10.1111/J.1432-1033.1995.947_A.X  0.332
1996 Rossetto O, Gorza L, Schiavo G, Schiavo N, Scheller RH, Montecucco C. VAMP/synaptobrevin isoforms 1 and 2 are widely and differentially expressed in nonneuronal tissues. The Journal of Cell Biology. 132: 167-79. PMID 8567721 DOI: 10.1083/Jcb.132.1.167  0.544
1996 Schiavo G, Rossetto O, Tonello F, Montecucco C. Intracellular targets and metalloprotease activity of tetanus and botulism neurotoxins. Current Topics in Microbiology and Immunology. 195: 257-74. PMID 8542757 DOI: 10.1007/978-3-642-85173-5_12  0.577
1996 Deloye F, Schiavo G, Doussau F, Rossetto O, Montecucco C, Poulain B. Mode d'action moléculaire des neurotoxines botulique et tétanique MéDecine/Sciences. 12: 175. DOI: 10.4267/10608/708  0.401
1996 MONTECUCCO C. BACTERIAL TOXINS AND CELL MEMBRANE TRAFFIC Biochemical Society Transactions. 24: 628S-628S. DOI: 10.1042/Bst024628Sa  0.337
1995 Schiavo G, Rossetto O, Montecucco C. Clostridial neurotoxins as tools to investigate the molecular events of neurotransmitter release. Seminars in Cell Biology. 5: 221-9. PMID 7994006 DOI: 10.1006/Scel.1994.1028  0.618
1995 Menestrina G, Schiavo G, Montecucco C. Molecular mechanisms of action of bacterial protein toxins. Molecular Aspects of Medicine. 15: 79-193. PMID 7984032 DOI: 10.1016/0098-2997(94)90043-4  0.546
1995 Kochi SK, Schiavo G, Mock M, Montecucco C. Zinc content of the Bacillus anthracis lethal factor. Fems Microbiology Letters. 124: 343-8. PMID 7851740 DOI: 10.1111/J.1574-6968.1994.Tb07306.X  0.518
1995 Washbourne P, Schiavo G, Montecucco C. Vesicle-associated membrane protein-2 (synaptobrevin-2) forms a complex with synaptophysin. The Biochemical Journal. 305: 721-4. PMID 7848269 DOI: 10.1042/Bj3050721  0.598
1995 Ikonen E, Tagaya M, Ullrich O, Montecucco C, Simons K. Different requirements for NSF, SNAP, and Rab proteins in apical and basolateral transport in MDCK cells. Cell. 81: 571-80. PMID 7758111 DOI: 10.1016/0092-8674(95)90078-0  0.304
1995 Schiavo G, Shone CC, Bennett MK, Scheller RH, Montecucco C. Botulinum neurotoxin type C cleaves a single Lys-Ala bond within the carboxyl-terminal region of syntaxins. The Journal of Biological Chemistry. 270: 10566-70. PMID 7737992 DOI: 10.1074/Jbc.270.18.10566  0.553
1995 Schiavo G, Montecucco C. Tetanus and botulism neurotoxins: isolation and assay. Methods in Enzymology. 248: 643-52. PMID 7674951 DOI: 10.1016/0076-6879(95)48041-2  0.481
1995 Montecucco C, Papini E. Cell penetration of bacterial protein toxins. Trends in Microbiology. 3: 165-7; discussion 16. PMID 7627453 DOI: 10.1016/S0966-842X(00)88911-8  0.416
1995 Rossetto O, Deloye F, Poulain B, Pellizzari R, Schiavo G, Montecucco C. The metallo-proteinase activity of tetanus and botulism neurotoxins. Journal of Physiology, Paris. 89: 43-50. PMID 7581298 DOI: 10.1016/0928-4257(96)80550-X  0.63
1995 Nielander HB, Onofri F, Valtorta F, Schiavo G, Montecucco C, Greengard P, Benfenati F. Phosphorylation of VAMP/synaptobrevin in synaptic vesicles by endogenous protein kinases. Journal of Neurochemistry. 65: 1712-20. PMID 7561869 DOI: 10.1046/J.1471-4159.1995.65041712.X  0.571
1995 Filippis VD, Vangelista L, Schiavo G, Tonello F, Montecucco C. Structural studies on the zinc-endopeptidase light chain of tetanus neurotoxin. Febs Journal. 229: 61-69. DOI: 10.1111/J.1432-1033.1995.0061L.X  0.527
1995 Nielander HB, Onofri F, Valtorta F, Schiavo G, Montecucco C, Greengard P, Benfenati F. Phosphorylation of VAMP/synaptobrevin in synaptic vesicles Pharmacological Research. 31: 212. DOI: 10.1016/1043-6618(95)87108-X  0.525
1995 Montecucco C, Schiavo G, Rossetto O, Poulain B. The mechanism of action of tetanus and botullnum naurotoxins Toxicology Letters. 78: 8. DOI: 10.1016/0378-4274(95)94630-Y  0.436
1994 Papini E, de Bernard M, Bugnoli M, Milia E, Rappuoli R, Montecucco C. Cell vacuolization induced by Helicobacter pylori: inhibition by bafilomycins A1, B1, C1 and D. Fems Microbiology Letters. 113: 155-9. PMID 8262366 DOI: 10.1111/J.1574-6968.1993.Tb06507.X  0.307
1994 Montecucco C, Papini E, Schiavo G. Bacterial protein toxins penetrate cells via a four-step mechanism. Febs Letters. 346: 92-8. PMID 8206166 DOI: 10.1016/0014-5793(94)00449-8  0.598
1994 Rossetto O, Schiavo G, Montecucco C, Poulain B, Deloye F, Lozzi L, Shone CC. SNARE motif and neurotoxins. Nature. 372: 415-6. PMID 7984234 DOI: 10.1038/372415A0  0.528
1994 Schiavo G, Rossetto O, Benfenati F, Poulain B, Montecucco C. Tetanus and botulinum neurotoxins are zinc proteases specific for components of the neuroexocytosis apparatus. Annals of the New York Academy of Sciences. 710: 65-75. PMID 7786341 DOI: 10.1111/J.1749-6632.1994.Tb26614.X  0.61
1994 Montecucco C, Schiavo G. Mechanism of action of tetanus and botulinum neurotoxins. Molecular Microbiology. 13: 1-8. PMID 7527117 DOI: 10.1111/J.1365-2958.1994.Tb00396.X  0.621
1994 Schiavo G, Montecucco C. Response from Schiavo and Montecucco Trends in Microbiology. 2: 69. DOI: 10.1016/0966-842X(94)90533-9  0.449
1993 Poulain B, Rossetto O, Deloye F, Schiavo G, Tauc L, Montecucco C. Antibodies against rat brain vesicle-associated membrane protein (synaptobrevin) prevent inhibition of acetylcholine release by tetanus toxin or botulinum neurotoxin type B. Journal of Neurochemistry. 61: 1175-8. PMID 8395562 DOI: 10.1111/J.1471-4159.1993.Tb03640.X  0.594
1993 Patarnello T, Bargelloni L, Rossetto O, Schiavo G, Montecucco C. Neurotransmission and secretion. Nature. 364: 581-582. PMID 8350917 DOI: 10.1038/364582A0  0.497
1993 de Paiva A, Ashton AC, Foran P, Schiavo G, Montecucco C, Dolly JO. Botulinum A like type B and tetanus toxins fulfils criteria for being a zinc-dependent protease. Journal of Neurochemistry. 61: 2338-41. PMID 8245989 DOI: 10.1111/J.1471-4159.1993.Tb07482.X  0.526
1993 Schiavo G, Santucci A, Dasgupta BR, Mehta PP, Jontes J, Benfenati F, Wilson MC, Montecucco C. Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds. Febs Letters. 335: 99-103. PMID 8243676 DOI: 10.1016/0014-5793(93)80448-4  0.574
1993 Schiavo G, Poulain B, Benfenati F, DasGupta BR, Montecucco C. Novel targets and catalytic activities of bacterial protein toxins. Trends in Microbiology. 1: 170-4. PMID 8143134 DOI: 10.1016/0966-842X(93)90086-7  0.57
1993 Montecucco C, Schiavo G. Tetanus and botulism neurotoxins: a new group of zinc proteases. Trends in Biochemical Sciences. 18: 324-7. PMID 7901925 DOI: 10.1016/0968-0004(93)90065-U  0.586
1992 Rossetto O, Schiavo G, Polverino de Laureto P, Fabbiani S, Montecucco C. Surface topography of histidine residues of tetanus toxin probed by immobilized-metal-ion affinity chromatography. The Biochemical Journal. 9-12. PMID 1637325 DOI: 10.1042/Bj2850009  0.528
1992 Calappi E, Masserini M, Schiavo G, Montecucco C, Tettamanti G. Lipid interaction of tetanus neurotoxin. A calorimetric and fluorescence spectroscopy study. Febs Letters. 309: 107-10. PMID 1505672 DOI: 10.1016/0014-5793(92)81074-V  0.57
1992 Schiavo G, Poulain B, Rossetto O, Benfenati F, Tauc L, Montecucco C. Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc. The Embo Journal. 11: 3577-83. PMID 1396558 DOI: 10.1002/J.1460-2075.1992.Tb05441.X  0.609
1992 Montecucco C, Papini E, Schiavo G, Padovan E, Rossetto O. Ion channel and membrane translocation of diphtheria toxin. Fems Microbiology Immunology. 5: 101-11. PMID 1384590 DOI: 10.1111/J.1574-6968.1992.Tb05892.X  0.56
1992 Schiavo G, Benfenati F, Poulain B, Rossetto O, Polverino de Laureto P, DasGupta BR, Montecucco C. Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin. Nature. 359: 832-5. PMID 1331807 DOI: 10.1038/359832A0  0.597
1991 Schiavo G, Papini E, Genna G, Montecucco C. An intact interchain disulfide bond is required for the neurotoxicity of tetanus toxin. Infection and Immunity. 58: 4136-41. PMID 2254033 DOI: 10.1128/Iai.58.12.4136-4141.1990  0.582
1991 Padovan E, Papini E, Rappuoli R, Montecucco C. Determination of diphtheria toxin neutralizing antibody titers with a cell protein synthesis inhibition assay. Medical Microbiology and Immunology. 180: 29-35. PMID 2056964 DOI: 10.1007/Bf00191698  0.327
1991 Demel R, Schiavo G, de Kruijff B, Montecucco C. Lipid interaction of diphtheria toxin and mutants. A study with phospholipid and protein monolayers. European Journal of Biochemistry. 197: 481-6. PMID 2026170 DOI: 10.1111/J.1432-1033.1991.Tb15935.X  0.529
1991 Schiavo G, Ferrari G, Rossetto O, Montecucco C. Tetanus toxin receptor. Specific cross-linking of tetanus toxin to a protein of NGF-differentiated PC 12 cells. Febs Letters. 290: 227-30. PMID 1915881 DOI: 10.1016/0014-5793(91)81266-B  0.556
1991 Domenighini M, Montecucco C, Ripka WC, Rappuoli R. Computer modelling of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding. Molecular Microbiology. 5: 23-31. PMID 1901617 DOI: 10.1111/J.1365-2958.1991.Tb01822.X  0.317
1991 Schiavo G, Demel R, Montecucco C. On the role of polysialoglycosphingolipids as tetanus toxin receptors. A study with lipid monolayers. European Journal of Biochemistry. 199: 705-11. PMID 1868854 DOI: 10.1111/J.1432-1033.1991.Tb16174.X  0.564
1991 Rossetto O, Schiavo G, Ferrari G, Basso G, Montecucco C. Killing of neuroblastoma and pheochromocytoma cells in colture with tetanus-diphtheria hybrid toxins European Journal of Cancer and Clinical Oncology. 27: S84. DOI: 10.1016/0277-5379(91)91560-6  0.456
1990 Papini E, Schiavo G, Rappuoli R, Montecucco C. Histidine-21 is involved in diphtheria toxin NAD+ binding. Toxicon : Official Journal of the International Society On Toxinology. 28: 631-5. PMID 2402759 DOI: 10.1016/0041-0101(90)90251-2  0.525
1990 SCHIAVO G, PAPINI E, MONTECUCCO C. An intact interchain SS bond is required for the neurotoxicity of tetanus toxin Cell Biology International Reports. 14: 259. DOI: 10.1016/0309-1651(90)91135-Q  0.494
1989 Montecucco C. Photoreactive lipids for the study of membrane-penetrating toxins. Methods in Enzymology. 165: 347-57. PMID 3068489 DOI: 10.1016/S0076-6879(88)65052-X  0.354
1989 Montecucco C, Schiavo G, Dasgupta BR. Effect of pH on the interaction of botulinum neurotoxins A, B and E with liposomes. The Biochemical Journal. 259: 47-53. PMID 2719650 DOI: 10.1042/Bj2590047  0.539
1988 Papini E, Schiavo G, Tomasi M, Colombatti M, Rappuoli R, Montecucco C. Lipid interaction of diphtheria toxin and mutants with altered fragment B. 2. Hydrophobic photolabelling and cell intoxication. European Journal of Biochemistry. 169: 637-44. PMID 3691512 DOI: 10.1111/J.1432-1033.1987.Tb13655.X  0.586
1988 Papini E, Colonna R, Cusinato F, Montecucco C, Tomasi M, Rappuoli R. Lipid interaction of diphtheria toxin and mutants with altered fragment B. 1. Liposome aggregation and fusion. European Journal of Biochemistry. 169: 629-35. PMID 3691511 DOI: 10.1111/J.1432-1033.1987.Tb13654.X  0.355
1988 Montecucco C, Schiavo G, Gao Z, Bauerlein E, Boquet P, DasGupta BR. Interaction of botulinum and tetanus toxins with the lipid bilayer surface. The Biochemical Journal. 251: 379-83. PMID 3401212 DOI: 10.1042/Bj2510379  0.563
1988 Papini E, Sandoná D, Rappuoli R, Montecucco C. On the membrane translocation of diphtheria toxin: at low pH the toxin induces ion channels on cells. The Embo Journal. 7: 3353-3359. DOI: 10.1002/J.1460-2075.1988.Tb03207.X  0.364
1987 Papini E, Colonna R, Schiavo G, Cusinato F, Tomasi M, Rappuoli R, Montecucco C. Diphtheria toxin and its mutant crm 197 differ in their interaction with lipids. Febs Letters. 215: 73-8. PMID 3569541 DOI: 10.1016/0014-5793(87)80116-3  0.557
1987 Degli Esposti M, Avitabile E, Barilli M, Schiavo G, Montecucco C, Lenaz G. Comparative biochemistry of the ubiquinol-cytochrome c oxidoreductase (EC 1.10.2.2) isolated from different heart mitochondria. Comparative Biochemistry and Physiology. B, Comparative Biochemistry. 85: 543-52. PMID 3024904 DOI: 10.1016/0305-0491(86)90044-1  0.523
1987 Volpe P, Gutweniger HE, Montecucco C. Photolabeling of the integral proteins of skeletal muscle sarcoplasmic reticulum: comparison of junctional and nonjunctional membrane fractions. Archives of Biochemistry and Biophysics. 253: 138-45. PMID 2949700 DOI: 10.1016/0003-9861(87)90646-1  0.341
1987 Montecucco C, Schiavo G. 1-Palmitoyl-2-(p-benzoyl)benzoyl phosphatidylcholine, a photoactive phospholipid for the labelling of membrane components. The Biochemical Journal. 237: 309-12. PMID 2948491 DOI: 10.1042/Bj2370309  0.555
1987 Montecucco C, Schiavo G, Bacci B, Bisson R. Isolation and characterization of cytochrome c oxidase from bird and fish heart mitochondria. Comparative Biochemistry and Physiology. B, Comparative Biochemistry. 87: 851-6. PMID 2822348 DOI: 10.1016/0305-0491(87)90401-9  0.498
1987 Bisson R, Montecucco C. Diphtheria toxin membrane translocation: an open question Trends in Biochemical Sciences. 12: 181-182. DOI: 10.1016/0968-0004(87)90087-9  0.333
1986 Montecucco C, Schiavo G, Brunner J, Duflot E, Boquet P, Roa M. Tetanus toxin is labeled with photoactivatable phospholipids at low pH Biochemistry. 25: 919-924. PMID 3964653 DOI: 10.1021/Bi00352A027  0.566
1986 Montecucco C, Tomasi M, Schiavo G, Rappuoli R. Hydrophobic photolabelling of pertussis toxin subunits interacting with lipids. Febs Letters. 194: 301-4. PMID 3940899 DOI: 10.1016/0014-5793(86)80105-3  0.575
1986 Montecucco C, Schiavo G, Bisson R. ATP binding to bovine heart cytochrome c oxidase. A photoaffinity labelling study. The Biochemical Journal. 234: 241-3. PMID 3010954 DOI: 10.1042/Bj2340241  0.515
1986 Montecucco C. How do tetanus and botulinum toxins bind to neuronal membranes? Trends in Biochemical Sciences. 11: 314-317. DOI: 10.1016/0968-0004(86)90282-3  0.366
1985 Montecucco C, Schiavo G, Tomasi M. pH-dependence of the phospholipid interaction of diphtheria-toxin fragments. The Biochemical Journal. 231: 123-8. PMID 4062882 DOI: 10.1042/Bj2310123  0.557
1985 Gutweniger HE, Montecucco C. Hydrophobic photolabelling of sarcoplasmic reticulum with [125I]TID. The International Journal of Biochemistry. 17: 867-71. PMID 4043508 DOI: 10.1016/0020-711X(85)90168-5  0.338
1983 Montecucco C, Dabbeni-Sala F, Friedl P, Galante YM. Membrane topology of ATP synthase from bovine heart mitochondria and Escherichia coli. European Journal of Biochemistry. 132: 189-94. PMID 6301821 DOI: 10.1111/J.1432-1033.1983.Tb07346.X  0.3
1982 Montecucco C, Smith GA, Dabbeni-sala F, Johannsson A, Galante YM, Bisson R. Bilayer thickness and enzymatic activity in the mitochondrial cytochrome c oxidase and ATPase complex. Febs Letters. 144: 145-8. PMID 6286354 DOI: 10.1016/0014-5793(82)80588-7  0.356
1981 Gutweniger H, Bisson R, Montecucco C. Hydrophobic photolabelling of the yeast cytochrome c oxidase subunits in contact with lipids. Biochimica Et Biophysica Acta. 635: 187-93. PMID 6260163 DOI: 10.1016/0005-2728(81)90017-7  0.308
1980 Montecucco C, Rink TJ, Pozzan T, Metcalfe JC. Triggering of lymphocyte capping appears not to require changes in potential or ion fluxes across the plasma membrane. Biochimica Et Biophysica Acta. 595: 65-70. PMID 6985571 DOI: 10.1016/0005-2736(80)90248-5  0.359
1980 Rink TJ, Montecucco C, Hesketh TR, Tsien RY. Lymphocyte membrane potential assessed with fluorescent probes. Biochimica Et Biophysica Acta. 595: 15-30. PMID 6153065 DOI: 10.1016/0005-2736(80)90243-6  0.301
1980 Bisson R, Montecucco C, Capaldi RA. Interaction of membranous cytochrome b5 with arylazidophospholipids. Febs Letters. 106: 317-20. PMID 499515 DOI: 10.1016/0014-5793(79)80523-2  0.349
1979 Montecucco C, Pozzan T, Rink T. Dicarbocyanine fluorescent probes of membrane potential block lymphocyte capping, deplete cellular ATP and inhibit respiration of isolated mitochondria. Biochimica Et Biophysica Acta. 552: 552-7. PMID 87222 DOI: 10.1016/0005-2736(79)90201-3  0.335
1977 Bisson R, Gutweniger H, Montecucco C, Colonna R, Zanotti A, Azzi A. Covalent binding of arylazido derivatives of cytochrome c to cytochrome oxidase. Febs Letters. 81: 147-50. PMID 198251 DOI: 10.1016/0014-5793(77)80948-4  0.367
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