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Barry Lygo, Ph.D - Publications

Affiliations: 
1987-1999 Chemistry University of Salford, UK 
 1999-2014 Chemistry University of Nottingham, Nottingham, England, United Kingdom 
Area:
Natural product synthesis, Catalysis
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61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Burroughs L, Eccleshare L, Ritchie J, Kulkarni O, Lygo B, Woodward S, Lewis W. One-Pot Cannizzaro Cascade Synthesis of ortho-Fused Cycloocta-2,5-dien-1-ones from 2-Bromo(hetero)aryl Aldehydes. Angewandte Chemie (International Ed. in English). 54: 10648-51. PMID 26230528 DOI: 10.1002/Anie.201505347  0.54
2014 Lygo B, Palframan MJ, Pattenden G. Investigation of transannular cycloaddition reactions involving furanoxonium ions using DFT calculations. Implications for the origin of plumarellide and rameswaralide and related polycyclic metabolites isolated from corals. Organic & Biomolecular Chemistry. 12: 7270-8. PMID 25105757 DOI: 10.1039/C4Ob00734D  0.323
2012 Lygo B, Butt U, Cormack M. Synthesis and evaluation of atropos dihydro-5H-dibenzazepinium halide PTCs derived from α-methylbenzylamine. Organic & Biomolecular Chemistry. 10: 4968-76. PMID 22614161 DOI: 10.1039/C2Ob25437A  0.447
2011 Lucas CL, Lygo B, Blake AJ, Lewis W, Moody CJ. Regioselectivity of the Claisen rearrangement in meta-allyloxy aryl ketones: an experimental and computational study, and application in the synthesis of (R)-(-)-pestalotheol D. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 1972-8. PMID 21274949 DOI: 10.1002/Chem.201002757  0.409
2011 Lygo B, Davison C, Evans T, Gilks JAR, Leonard J, Roy CE. Highly enantioselective aldol reactions using a tropos dibenz[c,e]azepine organocatalyst Tetrahedron. 67: 10164-10170. DOI: 10.1016/J.Tet.2011.09.101  0.547
2010 Lygo B, Beynon C, McLeod MC, Roy CE, Wade CE. Application of asymmetric phase-transfer catalysis in the enantioselective synthesis of cis-5-substituted proline esters Tetrahedron. 66: 8832-8836. DOI: 10.1016/J.Tet.2010.09.075  0.514
2010 LYGO B. ChemInform Abstract: N-Acyl-2-methylaziridines: Synthesis and Utility in the C-Acylation of β-Ketoester Derived Dianions. Cheminform. 27: no-no. DOI: 10.1002/chin.199611287  0.3
2010 LYGO B. ChemInform Abstract: Reaction of Aziridines with Dianions Derived from β-Keto Esters: Application to the Preparation of Substituted Pyrrolidines. Cheminform. 25: no-no. DOI: 10.1002/chin.199425118  0.403
2010 LYGO B, O'CONNOR N. ChemInform Abstract: Reaction of Dianions Derived from γ-Substituted β-Keto Esters with Epoxides. Cheminform. 23: no-no. DOI: 10.1002/chin.199249151  0.388
2009 Sharma P, Lygo B, Lewis W, Moses JE. Biomimetic synthesis and structural reassignment of the tridachiahydropyrones. Journal of the American Chemical Society. 131: 5966-72. PMID 19341238 DOI: 10.1021/Ja900369Z  0.344
2009 Lygo B, Allbutt B, Beaumont DJ, Butt U, Gilks JAR. Synthesis and evaluation of chiral dibenzazepinium halide phase-transfer catalysts Synlett. 675-680. DOI: 10.1055/s-0028-1087810  0.315
2009 Lygo B, Beynon C, Lumley C, McLeod MC, Wade CE. Co-catalyst enhancement of enantioselective PTC Michael additions involving glycine imines Tetrahedron Letters. 50: 3363-3365. DOI: 10.1016/J.Tetlet.2009.02.123  0.395
2009 Lygo B. Edited by Keiji Maruoka Asymmetric phase transfer catalysis Wiley-VCH, 2008, 214pp. (hardcover) ISBN 978-3-527-31842-1 Applied Organometallic Chemistry. 24: 65-65. DOI: 10.1002/Aoc.1571  0.324
2008 Lygo B, Kirton EH, Lumley C. Stereocontrolled synthesis of lepadiformine A. Organic & Biomolecular Chemistry. 6: 3085-90. PMID 18698466 DOI: 10.1039/B805951A  0.502
2007 Lygo B, Gardiner SD, McLeod MC, To DC. Diastereo- and enantioselective synthesis of alpha,beta-epoxyketones using aqueous NaOCl in conjunction with dihydrocinchonidine derived phase-transfer catalysis at room temperature. Scope and limitations. Organic & Biomolecular Chemistry. 5: 2283-90. PMID 17609760 DOI: 10.1039/B706546A  0.407
2007 Lygo B, Beaumont DJ. Two highly effective phase-transfer catalysts for the enantioselective synthesis of α-amino acid derivatives Chimia. 61: 257-262. DOI: 10.2533/Chimia.2007.257  0.455
2005 Lygo B, Hirst DJ. IMDA reactions of β,δ-diketoester-substituted 1,7,9-undecatrienes: Application in the formal synthesis of solanapyrone D Synthesis. 3257-3262. DOI: 10.1055/S-2005-918445  0.471
2005 Lygo B, Slack D, Wilson C. Synthesis of neodysiherbaine Tetrahedron Letters. 46: 6629-6632. DOI: 10.1016/J.Tetlet.2005.07.159  0.527
2005 Lygo B, Allbutt B, Kirton EHM. Asymmetric Michael addition of glycine imines via quaternary ammonium ion catalysis Tetrahedron Letters. 46: 4461-4464. DOI: 10.1016/J.Tetlet.2005.04.096  0.445
2004 Lygo B, Andrews BI. Asymmetric phase-transfer catalysis utilizing chiral quaternary ammonium salts: asymmetric alkylation of glycine imines. Accounts of Chemical Research. 37: 518-25. PMID 15311950 DOI: 10.1021/ar030058t  0.351
2004 Melville JL, Andrews BI, Lygo B, Hirst JD. Computational screening of combinatorial catalyst libraries. Chemical Communications (Cambridge, England). 1410-1. PMID 15179489 DOI: 10.1039/B402378A  0.338
2004 Lygo B, Humphreys LD. Enantioselective synthesis of renieramide Synlett. 2809-2811. DOI: 10.1055/S-2004-835623  0.413
2004 Lygo B, Allbutt B. Asymmetric PTC Alkylation of Glycine Imines: Variation of the Imine Ester Moiety Synlett. 326-328. DOI: 10.1055/S-2003-43368  0.539
2003 Albrow V, Biswas K, Crane A, Chaplin N, Easun T, Gladiali S, Lygo B, Woodward S. Synthesis of an octahydro-1,1′-binaphthyl thioether ligand and comparison with unhydrogenated binaphthyl analogues Tetrahedron Asymmetry. 14: 2813-2819. DOI: 10.1016/S0957-4166(03)00583-4  0.321
2003 Lygo B, Allbutt B, James SR. Identification of a highly effective asymmetric phase-transfer catalyst derived from α-methylnaphthylamine Tetrahedron Letters. 44: 5629-5632. DOI: 10.1016/S0040-4039(03)01352-2  0.457
2003 Lygo B, Andrews BI. Enantioselective synthesis of aroylalanine derivatives Tetrahedron Letters. 44: 4499-4502. DOI: 10.1016/S0040-4039(03)01017-7  0.518
2003 Lygo B, Bhatia M, Cooke JWB, Hirst DJ. Synthesis of (±)-solanapyrones A and B Tetrahedron Letters. 44: 2529-2532. DOI: 10.1016/S0040-4039(03)00288-0  0.36
2003 Lygo B, Andrews BI, Slack D. Stereoselective approach to C-glycosylasparagines Tetrahedron Letters. 44: 9039-9041. DOI: 10.1016/J.Tetlet.2003.09.212  0.45
2002 Lygo B, To DC. Asymmetric epoxidation via phase-transfer catalysis: direct conversion of allylic alcohols into alpha,beta-epoxyketones. Chemical Communications (Cambridge, England). 2360-1. PMID 12430440 DOI: 10.1039/B206530D  0.376
2002 Lygo B, Andrews BI, Crosby J, Peterson JA. Asymmetric alkylation of glycine imines using in situ generated phase-transfer catalysts Tetrahedron Letters. 43: 8015-8018. DOI: 10.1016/S0040-4039(02)01982-2  0.443
2002 Lygo B, Humphreys LD. Enantioselective synthesis of α-carbon deuterium-labelled L-α-amino acids Tetrahedron Letters. 43: 6677-6679. DOI: 10.1016/S0040-4039(02)01251-0  0.451
2001 Lygo B, To DCM. Improved procedure for the room temperature asymmetric phase-transfer mediated epoxidation of α,β-unsaturated ketones Tetrahedron Letters. 42: 1343-1346. DOI: 10.1016/S0040-4039(00)02208-5  0.444
2001 Lygo B, Crosby J, Peterson JA. An enantioselective approach to bis-α-amino acids Tetrahedron. 57: 6447-6453. DOI: 10.1016/S0040-4020(01)00536-1  0.465
2001 Lygo B, Crosby J, Lowdon TR, Peterson JA, Wainwright PG. Studies on the enantioselective synthesis of α-amino acids via asymmetric phase-transfer catalysis Tetrahedron. 57: 2403-2409. DOI: 10.1016/S0040-4020(01)00094-1  0.5
2001 Lygo B, Crosby J, Lowdon TR, Wainwright PG. Structure-selectivity studies on catalysts for the phase-transfer catalysed asymmetric alkylation of glycine imine esters Tetrahedron. 57: 2391-2402. DOI: 10.1016/S0040-4020(01)00093-X  0.427
1999 Lygo B. Enantioselective synthesis of dityrosine and isodityrosine via asymmetric phase-transfer catalysis Tetrahedron Letters. 40: 1389-1392. DOI: 10.1016/S0040-4039(98)02616-1  0.344
1999 Lygo B, Crosby J, Peterson JA. Enantioselective synthesis of bis-α-amino acid esters via asymmetric phase-transfer catalysis Tetrahedron Letters. 40: 1385-1388. DOI: 10.1016/S0040-4039(98)02615-X  0.383
1998 Lygo B, Wainwright PG. Asymmetric phase-transfer mediated epoxidation of α,β-unsaturated ketones using catalysts derived from Cinchona alkaloids Tetrahedron Letters. 39: 1599-1602. DOI: 10.1016/S0040-4039(97)10779-1  0.309
1997 Lygo B, Wainwright PG. A new class of asymmetric phase-transfer catalysts derived from Cinchona alkaloids - Application in the enantioselective synthesis of α-amino acids Tetrahedron Letters. 38: 8595-8598. DOI: 10.1016/S0040-4039(97)10293-3  0.372
1997 Lygo B, Crosby J, Lowdon TR, Wainwright PG. Enantio- and diastereoselective synthesis of all four possible stereoisomers of 2-(phenylhydroxymethyl)quinuclidine Tetrahedron Letters. 38: 2343-2346. DOI: 10.1016/S0040-4039(97)00310-9  0.392
1993 Lygo B. Reaction of Aziridines with Dianions Derived from β-Ketoesters: Application to the Preparation of Substituted Pyrrolidines Synlett. 1993: 764-766. DOI: 10.1055/s-1993-22601  0.364
1992 Lygo B, O'Connor N. Reaction of Dianions Derived from γ-Substituted β-Keto Esters with Epoxides Synlett. 1992: 529-530. DOI: 10.1055/s-1992-21404  0.373
1990 LEY SV, ANTHONY NJ, ARMSTRONG A, BRASCA MG, CLARKE T, CULSHAW D, GRECK C, GRICE P, JONES AB, LYGO B, MADIN A, SHEPPARD RN, SLAWIN AMZ, WILLIAMS DJ. ChemInform Abstract: A Highly Convergent Total Synthesis of the Spiroacetal Macrolide (+)-Milbemycin β1. Cheminform. 21. DOI: 10.1002/chin.199011329  0.411
1989 Ley SV, Anthony NJ, Armstrong A, Brasca MG, Clarke T, Culshaw D, Greck C, Grice P, Jones AB, Lygo B, Madin A, Sheppard RN, Slawin AMZ, Williams DJ. A highly convergent total synthesis of the spiroacetal macrolide (+)-milbemycinβ1 Tetrahedron. 45: 7161-7194. DOI: 10.1016/S0040-4020(01)89182-1  0.573
1988 Lygo B, O'connor N, Wilson PR. Reaction of dianions derived from β-ketoesters with epoxides-utility in the preparation of synthetically useful tetrahydrofurans Tetrahedron. 44: 6881-6888. DOI: 10.1016/S0040-4020(01)86217-7  0.361
1986 Ley SV, Lygo B, Sternfeld F, Wonnacott A. Alkylation reactions of anions derived from 2-benzenesulphonyl tetrahydropyran and their application to spiroketal syntiesis Tetrahedron. 42: 4333-4342. DOI: 10.1016/S0040-4020(01)87660-2  0.525
1986 LEY SV, LYGO B, STERNFELD F, WONNACOTT A. ChemInform Abstract: Alkylation Reactions of Anions Derived from 2-Benzenesulphonyl Tetrahydropyran and Their Application to Spiroketal Synthesis. Chemischer Informationsdienst. 17. DOI: 10.1002/chin.198652180  0.571
1985 Ley SV, Lygo B, Organ HM, Wonnacott A. Wittig and horner-wittig coupling reactions of 2-substituted cyclic ethers and their application to spiroketal synthesis Tetrahedron. 41: 3825-3836. DOI: 10.1016/S0040-4020(01)91403-6  0.561
1985 LEY SV, LYGO B, ORGAN HM, WONNACOTT A. ChemInform Abstract: Wittig and Horner-Wittig Coupling Reactions of 2-Substituted Cyclic Ethers and Their Application to Spiroketal Synthesis. Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198552214  0.549
1985 LEY SV, LYGO B, WONNACOTT A. ChemInform Abstract: PREPARATION AND REACTIONS OF 2-BENZENESULFONYLTETRAHYDROPYRAN Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198523189  0.495
1985 Ley SV, Lygo B, Wonnacott A. Preparation and reactions of 2-benzenesulphonyltetrahydropyran Tetrahedron Letters. 26: 535-538. DOI: 10.1002/Chin.198523189  0.471
1985 GODOY J, LEY SV, LYGO B. ChemInform Abstract: SYNTHESIS OF THE SPIROACETAL UNIT RELATED TO THE AVERMECTINS AND MILBEMYCINS Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198507204  0.43
1985 LEY SV, LYGO B, MOLINES H. ChemInform Abstract: SYNTHESIS OF (.+-.)-CIS-6-METHYLTETRAHYDROPYRAN-2-YLACETIC ACID, A NATURAL PRODUCT FROM VIVERRA CIVETTA, USING ORGANOSELENIUM-MEDIATED CYCLIZATION REACTIONS Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198504341  0.527
1984 Ley SV, Lygo B, Molines H. Synthesis of (±)-cis-6-methyltetrahydropyran-2-ylacetic acid, a natural product from viverra civetta, using organoselenium-mediated cyclisation reactions Journal of the Chemical Society, Perkin Transactions 1. 2403-2405. DOI: 10.1039/P19840002403  0.52
1984 Ley SV, Lygo B. A new route to spiro-ketals using the Horner-Wittig reaction of 2-diphenylphosphinoxy cyclic ethers Tetrahedron Letters. 25: 113-116. DOI: 10.1016/S0040-4039(01)91163-3  0.53
1984 DOHERTY AM, LEY SV, LYGO B, WILLIAMS DJ. ChemInform Abstract: SYNTHESIS OF SPIROACETALS USING ORGANOSELENIUM-MEDIATED CYCLIZATION REACTIONS. X-RAY MOLECULAR STRUCTURE O (2S,8R)-8-METHYL-2-PHENYL-1,7-DIOXASPIRO(5.5)UNDECAN-4(R)-OL Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198438356  0.403
1984 LEY SV, LYGO B. ChemInform Abstract: A NEW ROUTE TO SPIRO-KETALS USING THE HORNER-WITTIG REACTION OF 2-DIPHENYLPHOSPHINOXY CYCLIC ETHERS Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198417241  0.51
1983 LEY SV, LYGO B, MOLINES H, MORTON JA. ChemInform Abstract: SYNTHESIS OF (CIS-6-METHYLTETRAHYDROPYRAN-2-YL)ACETIC ACID INVOLVING THE USE OF AN ORGANOSELENIUM-MEDIATED CYCLIZATION REACTION Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198315227  0.532
1983 LEY SV, LYGO B. ChemInform Abstract: SYNTHESIS OF METHYL-1,6-DIOXASPIRO(4,5)DECANES USING ORGANOSELENIUM-MEDIATED CYCLIZATION REACTIONS Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198309201  0.54
1982 Ley SV, Lygo B. Synthesis of methyl-1,6-dioxaspiro[4,5]decanes using organoselenium mediated cyclization reactions Tetrahedron Letters. 23: 4625-4628. DOI: 10.1016/S0040-4039(00)85671-3  0.531
1982 Ley SV, Lygo B, Molines H, Morton JA. Synthesis of (cis-6-methyltetrahydropyran-2-yl)acetic acid involving the use of an organoselenium-mediated cyclization reaction Journal of the Chemical Society, Chemical Communications. 1251-1252. DOI: 10.1002/Chin.198315227  0.519
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