Brian F. O'Dowd - Publications

Affiliations: 
Pharmacology & Toxicology University of Toronto, Toronto, ON, Canada 

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Hasbi A, Perreault ML, Shen MYF, Fan T, Nguyen T, Alijaniaram M, Banasikowski TJ, Grace AA, O'Dowd BF, Fletcher PJ, George SR. Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB. Frontiers in Pharmacology. 8: 924. PMID 29354053 DOI: 10.3389/fphar.2017.00924  1
2014 Hasbi A, Perreault ML, Shen MY, Zhang L, To R, Fan T, Nguyen T, Ji X, O'Dowd BF, George SR. A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4806-20. PMID 25063849 DOI: 10.1096/fj.14-254037  1
2014 Kabli N, Fan T, O'Dowd BF, George SR. μ-δ opioid receptor heteromer-specific signaling in the striatum and hippocampus. Biochemical and Biophysical Research Communications. 450: 906-11. PMID 24976397 DOI: 10.1016/j.bbrc.2014.06.099  1
2014 Perreault ML, O'Dowd BF, George SR. Dopamine D₁-Dâ‚‚ receptor heteromer regulates signaling cascades involved in addiction: potential relevance to adolescent drug susceptibility. Developmental Neuroscience. 36: 287-96. PMID 24820626 DOI: 10.1159/000360158  1
2014 Perreault ML, Hasbi A, O'Dowd BF, George SR. Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevance. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 156-68. PMID 23774533 DOI: 10.1038/npp.2013.148  1
2013 Perreault ML, Fan T, O'Dowd BF, George SR. Enhanced brain-derived neurotrophic factor signaling in the nucleus accumbens of juvenile rats. Developmental Neuroscience. 35: 384-95. PMID 24021607 DOI: 10.1159/000351026  1
2013 O'Dowd BF, Nguyen T, Ji X, George SR. D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation. Biochemical and Biophysical Research Communications. 431: 586-9. PMID 23318175 DOI: 10.1016/j.bbrc.2012.12.139  1
2013 Novak G, Fan T, O'Dowd BF, George SR. Postnatal maternal deprivation and pubertal stress have additive effects on dopamine D2 receptor and CaMKII beta expression in the striatum. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 31: 189-95. PMID 23313435 DOI: 10.1016/j.ijdevneu.2013.01.001  1
2013 Novak G, Fan T, O'Dowd BF, George SR. Striatal development involves a switch in gene expression networks, followed by a myelination event: implications for neuropsychiatric disease. Synapse (New York, N.Y.). 67: 179-88. PMID 23184870 DOI: 10.1002/syn.21628  1
2013 Perreault ML, Jones-Tabah J, O'Dowd BF, George SR. A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 477-83. PMID 22827965 DOI: 10.1017/S1461145712000685  1
2012 O'Dowd BF, Ji X, O'Dowd PB, Nguyen T, George SR. Disruption of the mu-delta opioid receptor heteromer. Biochemical and Biophysical Research Communications. 422: 556-60. PMID 22583900 DOI: 10.1016/j.bbrc.2012.05.023  1
2012 Perreault ML, Fan T, Alijaniaram M, O'Dowd BF, George SR. Dopamine D1-D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1/2. Plos One. 7: e33348. PMID 22428025 DOI: 10.1371/journal.pone.0033348  1
2012 O'Dowd BF, Ji X, Nguyen T, George SR. Two amino acids in each of D1 and D2 dopamine receptor cytoplasmic regions are involved in D1-D2 heteromer formation. Biochemical and Biophysical Research Communications. 417: 23-8. PMID 22100647 DOI: 10.1016/j.bbrc.2011.11.027  1
2011 Perreault ML, Hasbi A, O'Dowd BF, George SR. The dopamine d1-d2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in Basal Ganglia. Frontiers in Neuroanatomy. 5: 31. PMID 21747759 DOI: 10.3389/fnana.2011.00031  1
2011 Hasbi A, O'Dowd BF, George SR. Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance. Molecular Brain. 4: 26. PMID 21663703 DOI: 10.1186/1756-6606-4-26  1
2011 O'Dowd BF, Ji X, Alijaniaram M, Nguyen T, George SR. Separation and reformation of cell surface dopamine receptor oligomers visualized in cells. European Journal of Pharmacology. 658: 74-83. PMID 21371461 DOI: 10.1016/j.ejphar.2011.02.030  1
2011 Kong MM, Verma V, O'Dowd BF, George SR. The role of palmitoylation in directing dopamine D1 receptor internalization through selective endocytic routes. Biochemical and Biophysical Research Communications. 405: 445-9. PMID 21241663 DOI: 10.1016/j.bbrc.2011.01.050  0.84
2011 Perreault ML, O'Dowd BF, George SR. Dopamine receptor homooligomers and heterooligomers in schizophrenia. Cns Neuroscience & Therapeutics. 17: 52-7. PMID 21199449 DOI: 10.1111/j.1755-5949.2010.00228.x  0.92
2010 Perreault ML, Hasbi A, Alijaniaram M, Fan T, Varghese G, Fletcher PJ, Seeman P, O'Dowd BF, George SR. The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia. The Journal of Biological Chemistry. 285: 36625-34. PMID 20864528 DOI: 10.1074/jbc.M110.159954  1
2010 Verma V, Hasbi A, O'Dowd BF, George SR. Dopamine D1-D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal activation: dual functional regulation by G protein-coupled receptor kinase 2. The Journal of Biological Chemistry. 285: 35092-103. PMID 20807772 DOI: 10.1074/jbc.M109.088625  0.6
2010 Lee DK, Ferguson SS, George SR, O'Dowd BF. The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with beta-arrestin. Biochemical and Biophysical Research Communications. 395: 185-9. PMID 20353754 DOI: 10.1016/j.bbrc.2010.03.151  1
2010 Hasbi A, O'Dowd BF, George SR. Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms. Current Opinion in Pharmacology. 10: 93-9. PMID 19897420 DOI: 10.1016/j.coph.2009.09.011  1
2010 El-Ghundi MB, Fan T, Karasinska JM, Yeung J, Zhou M, O'Dowd BF, George SR. Restoration of amphetamine-induced locomotor sensitization in dopamine D1 receptor-deficient mice. Psychopharmacology. 207: 599-618. PMID 19830406 DOI: 10.1007/s00213-009-1690-5  1
2009 Hasbi A, Fan T, Alijaniaram M, Nguyen T, Perreault ML, O'Dowd BF, George SR. Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth. Proceedings of the National Academy of Sciences of the United States of America. 106: 21377-82. PMID 19948956 DOI: 10.1073/pnas.0903676106  1
2009 So CH, Verma V, Alijaniaram M, Cheng R, Rashid AJ, O'Dowd BF, George SR. Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers. Molecular Pharmacology. 75: 843-54. PMID 19171671 DOI: 10.1124/mol.108.051805  1
2008 Juhasz JR, Hasbi A, Rashid AJ, So CH, George SR, O'Dowd BF. Mu-opioid receptor heterooligomer formation with the dopamine D1 receptor as directly visualized in living cells. European Journal of Pharmacology. 581: 235-43. PMID 18237729 DOI: 10.1016/j.ejphar.2007.11.060  1
2007 George SR, O'Dowd BF. A novel dopamine receptor signaling unit in brain: heterooligomers of D1 and D2 dopamine receptors. Thescientificworldjournal. 7: 58-63. PMID 17982577 DOI: 10.1100/tsw.2007.223  1
2007 Rashid AJ, O'Dowd BF, Verma V, George SR. Neuronal Gq/11-coupled dopamine receptors: an uncharted role for dopamine. Trends in Pharmacological Sciences. 28: 551-5. PMID 17950471 DOI: 10.1016/j.tips.2007.10.001  1
2007 Hasbi A, Nguyen T, Fan T, Cheng R, Rashid A, Alijaniaram M, Rasenick MM, O'Dowd BF, George SR. Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists. Biochemistry. 46: 12997-3009. PMID 17941650 DOI: 10.1021/bi701436w  1
2007 Kong MM, Hasbi A, Mattocks M, Fan T, O'Dowd BF, George SR. Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1. Molecular Pharmacology. 72: 1157-70. PMID 17699686 DOI: 10.1124/mol.107.034769  1
2007 So CH, Verma V, O'Dowd BF, George SR. Desensitization of the dopamine D1 and D2 receptor hetero-oligomer mediated calcium signal by agonist occupancy of either receptor. Molecular Pharmacology. 72: 450-62. PMID 17519357 DOI: 10.1124/mol.107.034884  1
2007 El-Ghundi M, O'Dowd BF, George SR. Insights into the role of dopamine receptor systems in learning and memory. Reviews in the Neurosciences. 18: 37-66. PMID 17405450  1
2007 O'Dowd BF, Alijaniaram M, Ji X, Nguyen T, Eglen RM, George SR. Using ligand-induced conformational change to screen for compounds targeting G-protein-coupled receptors. Journal of Biomolecular Screening. 12: 175-85. PMID 17289935 DOI: 10.1177/1087057106298287  1
2007 Rashid AJ, So CH, Kong MM, Furtak T, El-Ghundi M, Cheng R, O'Dowd BF, George SR. D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proceedings of the National Academy of Sciences of the United States of America. 104: 654-9. PMID 17194762 DOI: 10.1073/pnas.0604049104  1
2006 Kong MM, Fan T, Varghese G, O'dowd BF, George SR. Agonist-induced cell surface trafficking of an intracellularly sequestered D1 dopamine receptor homo-oligomer. Molecular Pharmacology. 70: 78-89. PMID 16597839 DOI: 10.1124/mol.105.021246  1
2006 Lee DK, George SR, O'Dowd BF. Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity. Trends in Pharmacological Sciences. 27: 190-4. PMID 16530855 DOI: 10.1016/j.tips.2006.02.006  1
2005 Karasinska JM, George SR, Cheng R, O'Dowd BF. Deletion of dopamine D1 and D3 receptors differentially affects spontaneous behaviour and cocaine-induced locomotor activity, reward and CREB phosphorylation. The European Journal of Neuroscience. 22: 1741-50. PMID 16197514 DOI: 10.1111/j.1460-9568.2005.04353.x  1
2005 Fan T, Varghese G, Nguyen T, Tse R, O'Dowd BF, George SR. A role for the distal carboxyl tails in generating the novel pharmacology and G protein activation profile of mu and delta opioid receptor hetero-oligomers. The Journal of Biological Chemistry. 280: 38478-88. PMID 16159882 DOI: 10.1074/jbc.M505644200  1
2005 O'Dowd BF, Ji X, Alijaniaram M, Rajaram RD, Kong MM, Rashid A, Nguyen T, George SR. Dopamine receptor oligomerization visualized in living cells. The Journal of Biological Chemistry. 280: 37225-35. PMID 16115864 DOI: 10.1074/jbc.M504562200  1
2005 Hasbi A, O'Dowd BF, George SR. A G protein-coupled receptor for estrogen: the end of the search? Molecular Interventions. 5: 158-61. PMID 15994455 DOI: 10.1124/mi.5.3.5  0.92
2005 So CH, Varghese G, Curley KJ, Kong MM, Alijaniaram M, Ji X, Nguyen T, O'dowd BF, George SR. D1 and D2 dopamine receptors form heterooligomers and cointernalize after selective activation of either receptor. Molecular Pharmacology. 68: 568-78. PMID 15923381 DOI: 10.1124/mol.105.012229  1
2005 Seeman P, Weinshenker D, Quirion R, Srivastava LK, Bhardwaj SK, Grandy DK, Premont RT, Sotnikova TD, Boksa P, El-Ghundi M, O'dowd BF, George SR, Perreault ML, Männistö PT, Robinson S, et al. Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 3513-8. PMID 15716360 DOI: 10.1073/pnas.0409766102  1
2005 Lee DK, Saldivia VR, Nguyen T, Cheng R, George SR, O'Dowd BF. Modification of the terminal residue of apelin-13 antagonizes its hypotensive action. Endocrinology. 146: 231-6. PMID 15486224 DOI: 10.1210/en.2004-0359  1
2004 Lee SP, So CH, Rashid AJ, Varghese G, Cheng R, Lança AJ, O'Dowd BF, George SR. Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal. The Journal of Biological Chemistry. 279: 35671-8. PMID 15159403 DOI: 10.1074/jbc.M401923200  1
2004 Rashid AJ, O'Dowd BF, George SR. Minireview: Diversity and complexity of signaling through peptidergic G protein-coupled receptors. Endocrinology. 145: 2645-52. PMID 15044354 DOI: 10.1210/en.2004-0052  1
2004 Lee DK, Lança AJ, Cheng R, Nguyen T, Ji XD, Gobeil F, Chemtob S, George SR, O'Dowd BF. Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. The Journal of Biological Chemistry. 279: 7901-8. PMID 14645236 DOI: 10.1074/jbc.M306377200  1
2003 Madras BK, Fahey MA, Miller GM, De La Garza R, Goulet M, Spealman RD, Meltzer PC, George SR, O'Dowd BF, Bonab AA, Livni E, Fischman AJ. Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors. European Journal of Pharmacology. 479: 41-51. PMID 14612136 DOI: 10.1016/j.ejphar.2003.08.055  1
2003 Lee DK, George SR, O'Dowd BF. Continued discovery of ligands for G protein-coupled receptors. Life Sciences. 74: 293-7. PMID 14607257 DOI: 10.1016/j.lfs.2003.09.016  1
2003 Lee SP, O'Dowd BF, George SR. Homo- and hetero-oligomerization of G protein-coupled receptors. Life Sciences. 74: 173-80. PMID 14607244 DOI: 10.1016/j.lfs.2003.09.028  1
2003 Vanti WB, Muglia P, Nguyen T, Cheng R, Kennedy JL, George SR, O'Dowd BF. Discovery of a null mutation in a human trace amine receptor gene. Genomics. 82: 531-6. PMID 14559210 DOI: 10.1016/S0888-7543(03)00173-3  1
2003 Thompson MD, Storm van's Gravesande K, Galczenski H, Burnham WM, Siminovitch KA, Zamel N, Slutsky A, Drazen JM, George SR, Evans JF, O'Dowd BF. A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. Pharmacogenetics. 13: 641-9. PMID 14515063 DOI: 10.1097/01.fpc.0000054127.14659.42  1
2003 Lee SP, O'Dowd BF, Rajaram RD, Nguyen T, George SR. D2 dopamine receptor homodimerization is mediated by multiple sites of interaction, including an intermolecular interaction involving transmembrane domain 4. Biochemistry. 42: 11023-31. PMID 12974638 DOI: 10.1021/bi0345539  1
2003 George SR, Ng GY, Lee SP, Fan T, Varghese G, Wang C, Deber CM, Seeman P, O'Dowd BF. Blockade of G protein-coupled receptors and the dopamine transporter by a transmembrane domain peptide: novel strategy for functional inhibition of membrane proteins in vivo. The Journal of Pharmacology and Experimental Therapeutics. 307: 481-9. PMID 12970389 DOI: 10.1124/jpet.103.053843  1
2003 Vanti WB, Nguyen T, Cheng R, Lynch KR, George SR, O'Dowd BF. Novel human G-protein-coupled receptors. Biochemical and Biophysical Research Communications. 305: 67-71. PMID 12732197 DOI: 10.1016/S0006-291X(03)00709-5  1
2003 Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, et al. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Proceedings of the National Academy of Sciences of the United States of America. 100: 6251-6. PMID 12719537 DOI: 10.1073/pnas.0837789100  1
2003 Karasinska JM, George SR, O'Dowd BF. Family 1 G protein-coupled receptor function in the CNS. Insights from gene knockout mice. Brain Research. Brain Research Reviews. 41: 125-52. PMID 12663079 DOI: 10.1016/S0165-0173(02)00221-7  1
2003 El-Ghundi M, O'Dowd BF, Erclik M, George SR. Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice. The European Journal of Neuroscience. 17: 851-62. PMID 12603275 DOI: 10.1046/j.1460-9568.2003.02496.x  1
2002 George SR, O'Dowd BF, Lee SP. G-protein-coupled receptor oligomerization and its potential for drug discovery. Nature Reviews. Drug Discovery. 1: 808-20. PMID 12360258 DOI: 10.1038/nrd913  1
2002 Lee DK, George SR, O'Dowd BF. Novel G-protein-coupled receptor genes expressed in the brain: continued discovery of important therapeutic targets. Expert Opinion On Therapeutic Targets. 6: 185-202. PMID 12223080 DOI: 10.1517/14728222.6.2.185  1
2002 Levac BA, O'Dowd BF, George SR. Oligomerization of opioid receptors: generation of novel signaling units. Current Opinion in Pharmacology. 2: 76-81. PMID 11786312 DOI: 10.1016/S1471-4892(02)00124-8  1
2002 Lamey M, Thompson M, Varghese G, Chi H, Sawzdargo M, George SR, O'Dowd BF. Distinct residues in the carboxyl tail mediate agonist-induced desensitization and internalization of the human dopamine D1 receptor. The Journal of Biological Chemistry. 277: 9415-21. PMID 11773080 DOI: 10.1074/jbc.M111811200  1
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