| Year |
Citation |
Score |
| 2022 |
Gulen B, Casey A, Orth K. AMPylation of small GTPases by Fic enzymes. Febs Letters. PMID 36239538 DOI: 10.1002/1873-3468.14516 |
0.359 |
|
| 2022 |
Lafrance AE, Chimalapati S, Garcia Rodriguez N, Kinch LN, Kaval KG, Orth K. Enzymatic Specificity of Conserved Rho GTPase Deamidases Promotes Invasion of Vibrio parahaemolyticus at the Expense of Infection. Mbio. e0162922. PMID 35862776 DOI: 10.1128/mbio.01629-22 |
0.359 |
|
| 2021 |
Ebrahimzadeh T, Kuprasertkul A, Neugent ML, Lutz KC, Fuentes JL, Gadhvi J, Khan F, Zhang C, Sharon BM, Orth K, Li Q, Zimmern PE, De Nisco NJ. Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal women. Life Science Alliance. 4. PMID 33958485 DOI: 10.26508/lsa.202000948 |
0.636 |
|
| 2021 |
Fernandez J, Lopez V, Kinch L, Pfeifer MA, Gray H, Garcia N, Grishin NV, Khang CH, Orth K. Role of Two Metacaspases in Development and Pathogenicity of the Rice Blast Fungus Magnaporthe oryzae. Mbio. 12. PMID 33563831 DOI: 10.1128/mBio.03471-20 |
0.327 |
|
| 2021 |
De Nisco NJ, Casey AK, Kanchwala M, Lafrance AE, Coskun FS, Kinch LN, Grishin NV, Xing C, Orth K. Manipulation of IRE1-Dependent MAPK Signaling by a Vibrio Agonist-Antagonist Effector Pair. Msystems. 6. PMID 33563785 DOI: 10.1128/mSystems.00872-20 |
0.74 |
|
| 2020 |
Chimalapati S, de Souza Santos M, Lafrance AE, Ray A, Lee WR, Rivera-Cancel G, Vale G, Pawlowski K, Mitsche MA, McDonald JG, Liou J, Orth K. Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress. Elife. 9. PMID 32808593 DOI: 10.7554/Elife.58057 |
0.418 |
|
| 2020 |
Huebinger RM, Do DH, Carlson DL, Yao X, Stones DH, De Souza Santos M, Vaz DP, Keen E, Wolf SE, Minei JP, Francis KP, Orth K, Krachler AM. Bacterial adhesion inhibitor prevents infection in a rodent surgical incision model. Virulence. 11: 695-706. PMID 32490711 DOI: 10.1080/21505594.2020.1772652 |
0.346 |
|
| 2020 |
Peng W, Casey AK, Fernandez J, Carpinone EM, Servage KA, Chen Z, Li Y, Tomchick DR, Starai VJ, Orth K. A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM. Nature Structural & Molecular Biology. PMID 32424347 DOI: 10.1038/S41594-020-0429-1 |
0.41 |
|
| 2020 |
Servage KA, Stefanius K, Gray HF, Orth K. Proteomic Profiling of Small Extracellular Vesicles Secreted by Human Pancreatic Cancer Cells Implicated in Cellular Transformation. Scientific Reports. 10: 7713. PMID 32382024 DOI: 10.1038/S41598-020-64718-6 |
0.338 |
|
| 2020 |
D'Souza RS, Lim JY, Turgut A, Servage K, Zhang J, Orth K, Sosale N, Lazzara M, Allegood J, Casanova JE. Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex. Elife. 9. PMID 32234213 DOI: 10.7554/Elife.54113 |
0.319 |
|
| 2020 |
Chimalapati S, Santos MdS, Lafrance AE, Ray A, Lee W, Rivera-Cancel G, Vale G, Pawlowski K, Mitsche MA, McDonald JG, Liou J, Orth K. Author response: Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress Elife. DOI: 10.7554/Elife.58057.Sa2 |
0.32 |
|
| 2019 |
Yang H, de Souza Santos M, Lee J, Law HT, Chimalapati S, Verdu EF, Orth K, Vallance BA. A Novel Mouse Model of Enteric Vibrio parahaemolyticus Infection Reveals that the Type III Secretion System 2 Effector VopC Plays a Key Role in Tissue Invasion and Gastroenteritis. Mbio. 10. PMID 31848276 DOI: 10.1128/Mbio.02608-19 |
0.421 |
|
| 2019 |
Bhargava V, Goldstein CD, Russell L, Xu L, Ahmed M, Li W, Casey A, Servage K, Kollipara R, Picciarelli Z, Kittler R, Yatsenko A, Carmell M, Orth K, Amatruda JF, et al. GCNA Preserves Genome Integrity and Fertility Across Species. Developmental Cell. PMID 31839537 DOI: 10.1016/J.Devcel.2019.11.007 |
0.331 |
|
| 2019 |
De Souza Santos M, Orth K. The Role of the Type III Secretion System in the Intracellular Lifestyle of Enteric Pathogens. Microbiology Spectrum. 7. PMID 31152523 DOI: 10.1128/microbiolspec.BAI-0008-2019 |
0.356 |
|
| 2019 |
Peng W, de Souza Santos M, Li Y, Tomchick DR, Orth K. High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers. Plos One. 14: e0213423. PMID 31048915 DOI: 10.1371/Journal.Pone.0213423 |
0.327 |
|
| 2019 |
De Nisco NJ, Neugent M, Mull J, Chen L, Kuprasertkul A, de Souza Santos M, Palmer KL, Zimmern P, Orth K. Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection. Journal of Molecular Biology. PMID 31002774 DOI: 10.1016/j.jmb.2019.04.008 |
0.674 |
|
| 2019 |
Orth K, Tyne DV, Koropatkin NM. Decision letter: Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis Elife. DOI: 10.7554/Elife.45343.038 |
0.3 |
|
| 2019 |
Tomchick DR, Sreelatha A, Yee SS, Lopez VA, Park BC, Kinch LN, Pilch S, Servage KA, Zhang J, Jiou J, Karasiewicz-Urbańska M, Łobocka M, Grishin NV, Orth K, Kucharczyk R, et al. Protein AMPylation by an evolutionarily conserved pseudokinase Acta Crystallographica Section A. 75. DOI: 10.1107/S0108767319096922 |
0.747 |
|
| 2018 |
Sreelatha A, Yee SS, Lopez VA, Park BC, Kinch LN, Pilch S, Servage KA, Zhang J, Jiou J, Karasiewicz-Urbańska M, Łobocka M, Grishin NV, Orth K, Kucharczyk R, Pawłowski K, et al. Protein AMPylation by an Evolutionarily Conserved Pseudokinase. Cell. PMID 30270044 DOI: 10.1016/J.Cell.2018.08.046 |
0.764 |
|
| 2018 |
Chimalapati S, de Souza Santos M, Servage K, De Nisco NJ, Dalia AB, Orth K. Natural transformation of: A rapid method to create genetic deletions. Journal of Bacteriology. PMID 29555695 DOI: 10.1128/Jb.00032-18 |
0.651 |
|
| 2018 |
Casey AK, Moehlman AT, Zhang J, Servage KA, Krämer H, Orth K. Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies. The Journal of Biological Chemistry. 293: 1550. PMID 29414767 DOI: 10.1074/Jbc.Aac118.001798 |
0.334 |
|
| 2018 |
Fernandez J, Orth K. Rise of a Cereal Killer: The Biology of Magnaporthe oryzae Biotrophic Growth. Trends in Microbiology. PMID 29395728 DOI: 10.1016/J.Tim.2017.12.007 |
0.38 |
|
| 2018 |
De Nisco NJ, Rivera-Cancel G, Orth K. The Biochemistry of Sensing: Enteric Pathogens Regulate Type III Secretion in Response to Environmental and Host Cues. Mbio. 9. PMID 29339429 DOI: 10.1128/Mbio.02122-17 |
0.722 |
|
| 2017 |
Ray A, Schwartz N, de Souza Santos M, Zhang J, Orth K, Salomon D. Type VI secretion system MIX-effectors carry both antibacterial and anti-eukaryotic activities. Embo Reports. PMID 28912123 DOI: 10.15252/Embr.201744226 |
0.416 |
|
| 2017 |
Casey AK, Orth K. Enzymes Involved in AMPylation and deAMPylation. Chemical Reviews. PMID 28819965 DOI: 10.1021/Acs.Chemrev.7B00145 |
0.368 |
|
| 2017 |
De Nisco NJ, Orth K, VanHook AM. Science Signaling Podcast for 16 May 2017: Vibrio rewires host cells. Science Signaling. 10. PMID 28512146 DOI: 10.1126/Scisignal.Aan5621 |
0.733 |
|
| 2017 |
De Nisco NJ, Kanchwala M, Li P, Fernandez J, Xing C, Orth K. The cytotoxic type 3 secretion system 1 of Vibrio rewires host gene expression to subvert cell death and activate cell survival pathways. Science Signaling. 10. PMID 28512145 DOI: 10.1126/Scisignal.Aal4501 |
0.744 |
|
| 2017 |
Li P, Kinch LN, Ray A, Dalia AB, Cong Q, Nunan LM, Camilli A, Grishin NV, Salomon D, Orth K. Acute Hepatopancreatic Necrosis Disease (AHPND)-causing Vibrio parahaemolyticus strains maintain an antibacterial Type VI Secretion System with versatile effector repertoires. Applied and Environmental Microbiology. PMID 28432099 DOI: 10.1128/Aem.00737-17 |
0.336 |
|
| 2017 |
Rivera-Cancel G, Orth K. Biochemical basis for activation of virulence genes by bile salts in Vibrio parahaemolyticus. Gut Microbes. 1-8. PMID 28129014 DOI: 10.1080/19490976.2017.1287655 |
0.311 |
|
| 2016 |
Ray A, Kinch LN, de Souza Santos M, Grishin NV, Orth K, Salomon D. Proteomics Analysis Reveals Previously Uncharacterized Virulence Factors in Vibrio proteolyticus. Mbio. 7. PMID 27460800 DOI: 10.1128/Mbio.01077-16 |
0.424 |
|
| 2016 |
Li P, Rivera-Cancel G, Kinch LN, Salomon D, Tomchick DR, Grishin NV, Orth K. Bile salt receptor complex activates a pathogenic type III secretion system. Elife. 5. PMID 27377244 DOI: 10.7554/Elife.15718 |
0.384 |
|
| 2015 |
Salomon D, Klimko JA, Trudgian DC, Kinch LN, Grishin NV, Mirzaei H, Orth K. Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria. Plos Pathogens. 11: e1005128. PMID 26305100 DOI: 10.1371/Journal.Ppat.1005128 |
0.438 |
|
| 2015 |
Sreelatha A, Bennett TL, Carpinone EM, O'Brien KM, Jordan KD, Burdette DL, Orth K, Starai VJ. Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes. Proceedings of the National Academy of Sciences of the United States of America. 112: 100-5. PMID 25453092 DOI: 10.1073/Pnas.1413764111 |
0.75 |
|
| 2015 |
de Souza Santos M, Orth K. Subversion of the cytoskeleton by intracellular bacteria: lessons from Listeria, Salmonella and Vibrio. Cellular Microbiology. 17: 164-73. PMID 25440316 DOI: 10.1111/Cmi.12399 |
0.431 |
|
| 2014 |
Woolery AR, Yu X, LaBaer J, Orth K. AMPylation of Rho GTPases subverts multiple host signaling processes. The Journal of Biological Chemistry. 289: 32977-88. PMID 25301945 DOI: 10.1074/Jbc.M114.601310 |
0.477 |
|
| 2014 |
de Souza Santos M, Orth K. Intracellular Vibrio parahaemolyticus escapes the vacuole and establishes a replicative niche in the cytosol of epithelial cells. Mbio. 5: e01506-14. PMID 25205094 DOI: 10.1128/mBio.01506-14 |
0.376 |
|
| 2014 |
Calder T, Kinch LN, Fernandez J, Salomon D, Grishin NV, Orth K. Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxins. Plos One. 9: e104387. PMID 25099122 DOI: 10.1371/Journal.Pone.0104387 |
0.451 |
|
| 2014 |
Yu X, Woolery AR, Luong P, Hao YH, Grammel M, Westcott N, Park J, Wang J, Bian X, Demirkan G, Hang HC, Orth K, LaBaer J. Copper-catalyzed azide-alkyne cycloaddition (click chemistry)-based detection of global pathogen-host AMPylation on self-assembled human protein microarrays. Molecular & Cellular Proteomics : McP. 13: 3164-76. PMID 25073739 DOI: 10.1074/Mcp.M114.041103 |
0.368 |
|
| 2014 |
Salomon D, Kinch LN, Trudgian DC, Guo X, Klimko JA, Grishin NV, Mirzaei H, Orth K. Marker for type VI secretion system effectors. Proceedings of the National Academy of Sciences of the United States of America. 111: 9271-6. PMID 24927539 DOI: 10.1073/Pnas.1406110111 |
0.352 |
|
| 2014 |
Lewallen DM, Sreelatha A, Dharmarajan V, Madoux F, Chase P, Griffin PR, Orth K, Hodder P, Thompson PR. Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation. Acs Chemical Biology. 9: 433-42. PMID 24274060 DOI: 10.1021/Cb4006886 |
0.78 |
|
| 2013 |
Salomon D, Guo Y, Kinch LN, Grishin NV, Gardner KH, Orth K. Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides. Nature Communications. 4: 2973. PMID 24346350 DOI: 10.1038/Ncomms3973 |
0.325 |
|
| 2013 |
Hawley CA, Watson CA, Orth K, Krachler AM. A MAM7 peptide-based inhibitor of Staphylococcus aureus adhesion does not interfere with in vitro host cell function. Plos One. 8: e81216. PMID 24265842 DOI: 10.1371/Journal.Pone.0081216 |
0.401 |
|
| 2013 |
Sreelatha A, Orth K, Starai VJ. The pore-forming bacterial effector, VopQ, halts autophagic turnover. Autophagy. 9: 2169-70. PMID 24145145 DOI: 10.4161/Auto.26449 |
0.78 |
|
| 2013 |
Salomon D, Orth K. What pathogens have taught us about posttranslational modifications. Cell Host & Microbe. 14: 269-79. PMID 24034613 DOI: 10.1016/J.Chom.2013.07.008 |
0.461 |
|
| 2013 |
Altura MA, Heath-Heckman EA, Gillette A, Kremer N, Krachler AM, Brennan C, Ruby EG, Orth K, McFall-Ngai MJ. The first engagement of partners in the Euprymna scolopes-Vibrio fischeri symbiosis is a two-step process initiated by a few environmental symbiont cells. Environmental Microbiology. 15: 2937-50. PMID 23819708 DOI: 10.1111/1462-2920.12179 |
0.399 |
|
| 2013 |
Krachler AM, Orth K. Targeting the bacteria-host interface: strategies in anti-adhesion therapy. Virulence. 4: 284-94. PMID 23799663 DOI: 10.4161/Viru.24606 |
0.393 |
|
| 2013 |
Sreelatha A, Bennett TL, Zheng H, Jiang QX, Orth K, Starai VJ. Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux. Proceedings of the National Academy of Sciences of the United States of America. 110: 11559-64. PMID 23798441 DOI: 10.1073/Pnas.1307032110 |
0.781 |
|
| 2013 |
Salomon D, Gonzalez H, Updegraff BL, Orth K. Vibrio parahaemolyticus type VI secretion system 1 is activated in marine conditions to target bacteria, and is differentially regulated from system 2. Plos One. 8: e61086. PMID 23613791 DOI: 10.1371/Journal.Pone.0061086 |
0.38 |
|
| 2013 |
Salomon D, Orth K. Lost after translation: post-translational modifications by bacterial type III effectors. Current Opinion in Microbiology. 16: 213-20. PMID 23466212 DOI: 10.1016/J.Mib.2013.01.013 |
0.463 |
|
| 2013 |
Zhang L, Orth K. Virulence determinants for Vibrio parahaemolyticus infection. Current Opinion in Microbiology. 16: 70-7. PMID 23433802 DOI: 10.1016/J.Mib.2013.02.002 |
0.428 |
|
| 2013 |
Krachler A, Orth K. Made to Stick: Anti-Adhesion Therapy for Bacterial Infections Microbe Magazine. 8: 286-290. DOI: 10.1128/Microbe.8.286.1 |
0.329 |
|
| 2012 |
Ham H, Orth K. The role of type III secretion System 2 in Vibrio parahaemolyticus pathogenicity Journal of Microbiology. 50: 719-725. PMID 23124738 DOI: 10.1007/s12275-012-2550-2 |
0.361 |
|
| 2012 |
Alto NM, Orth K. Subversion of cell signaling by pathogens. Cold Spring Harbor Perspectives in Biology. 4: a006114. PMID 22952390 DOI: 10.1101/Cshperspect.A006114 |
0.432 |
|
| 2012 |
Zhang L, Krachler AM, Broberg CA, Li Y, Mirzaei H, Gilpin CJ, Orth K. Type III effector VopC mediates invasion for Vibrio species. Cell Reports. 1: 453-60. PMID 22787576 DOI: 10.1016/J.Celrep.2012.04.004 |
0.445 |
|
| 2012 |
Krachler AM, Ham H, Orth K. Turnabout is fair play: use of the bacterial Multivalent Adhesion Molecule 7 as an antimicrobial agent. Virulence. 3: 68-71. PMID 22086133 DOI: 10.4161/Viru.3.1.18172 |
0.432 |
|
| 2011 |
Krachler AM, Woolery AR, Orth K. Manipulation of kinase signaling by bacterial pathogens. The Journal of Cell Biology. 195: 1083-92. PMID 22123833 DOI: 10.1083/Jcb.201107132 |
0.444 |
|
| 2011 |
Ham H, Orth K. De-AMPylation unmasked: Modulation of host membrane trafficking Science Signaling. 4. PMID 21990428 DOI: 10.1126/Scisignal.2002458 |
0.508 |
|
| 2011 |
Grammel M, Luong P, Orth K, Hang HC. A chemical reporter for protein AMPylation. Journal of the American Chemical Society. 133: 17103-5. PMID 21942216 DOI: 10.1021/Ja205137D |
0.379 |
|
| 2011 |
Krachler AM, Orth K. Functional characterization of the interaction between bacterial adhesin multivalent adhesion molecule 7 (MAM7) protein and its host cell ligands. The Journal of Biological Chemistry. 286: 38939-47. PMID 21937438 DOI: 10.1074/jbc.M111.291377 |
0.306 |
|
| 2011 |
Broberg CA, Calder TJ, Orth K. Vibrio parahaemolyticus cell biology and pathogenicity determinants. Microbes and Infection. 13: 992-1001. PMID 21782964 DOI: 10.1016/J.Micinf.2011.06.013 |
0.392 |
|
| 2011 |
Ham H, Sreelatha A, Orth K. Manipulation of host membranes by bacterial effectors Nature Reviews Microbiology. 9: 635-646. PMID 21765451 DOI: 10.1038/Nrmicro2602 |
0.779 |
|
| 2011 |
Krachler AM, Ham H, Orth K. Outer membrane adhesion factor multivalent adhesion molecule 7 initiates host cell binding during infection by gram-negative pathogens. Proceedings of the National Academy of Sciences of the United States of America. 108: 11614-9. PMID 21709226 DOI: 10.1073/pnas.1102360108 |
0.359 |
|
| 2010 |
Broberg CA, Zhang L, Gonzalez H, Laskowski-Arce MA, Orth K. A Vibrio effector protein is an inositol phosphatase and disrupts host cell membrane integrity. Science (New York, N.Y.). 329: 1660-2. PMID 20724587 DOI: 10.1126/Science.1192850 |
0.459 |
|
| 2010 |
Luong P, Kinch LN, Brautigam CA, Grishin NV, Tomchick DR, Orth K. Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain. The Journal of Biological Chemistry. 285: 20155-63. PMID 20410310 DOI: 10.1074/Jbc.M110.114884 |
0.302 |
|
| 2010 |
Broberg CA, Orth K. Tipping the balance by manipulating post-translational modifications. Current Opinion in Microbiology. 13: 34-40. PMID 20071215 DOI: 10.1016/j.mib.2009.12.004 |
0.325 |
|
| 2009 |
Burdette DL, Seemann J, Orth K. Vibrio VopQ induces PI3-kinase-independent autophagy and antagonizes phagocytosis. Molecular Microbiology. 73: 639-49. PMID 19627496 DOI: 10.1111/J.1365-2958.2009.06798.X |
0.758 |
|
| 2009 |
Yarbrough ML, Orth K. AMPylation is a new post-translational modiFICation. Nature Chemical Biology. 5: 378-9. PMID 19448605 DOI: 10.1038/Nchembio0609-378 |
0.355 |
|
| 2009 |
Yarbrough ML, Li Y, Kinch LN, Grishin NV, Ball HL, Orth K. AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. Science (New York, N.Y.). 323: 269-72. PMID 19039103 DOI: 10.1126/Science.1166382 |
0.457 |
|
| 2009 |
Burdette DL, Yarbrough ML, Orth K. Not without cause: Vibrio parahaemolyticus induces acute autophagy and cell death. Autophagy. 5: 100-2. PMID 19011375 DOI: 10.4161/Auto.5.1.7264 |
0.751 |
|
| 2008 |
Laskowski-Arce MA, Orth K. Acanthamoeba castellanii promotes the survival of Vibrio parahaemolyticus. Applied and Environmental Microbiology. 74: 7183-8. PMID 18849458 DOI: 10.1128/Aem.01332-08 |
0.323 |
|
| 2008 |
Burdette DL, Yarbrough ML, Orvedahl A, Gilpin CJ, Orth K. Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis. Proceedings of the National Academy of Sciences of the United States of America. 105: 12497-502. PMID 18713860 DOI: 10.1073/Pnas.0802773105 |
0.766 |
|
| 2008 |
Le Negrate G, Faustin B, Welsh K, Loeffler M, Krajewska M, Hasegawa P, Mukherjee S, Orth K, Krajewski S, Godzik A, Guiney DG, Reed JC. Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses. Journal of Immunology (Baltimore, Md. : 1950). 180: 5045-56. PMID 18354230 DOI: 10.4049/Jimmunol.180.7.5045 |
0.311 |
|
| 2008 |
Hao YH, Wang Y, Burdette D, Mukherjee S, Keitany G, Goldsmith E, Orth K. Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways. Plos One. 3: e1375. PMID 18167536 DOI: 10.1371/Journal.Pone.0001375 |
0.741 |
|
| 2008 |
Trosky JE, Liverman AD, Orth K. Yersinia outer proteins: Yops. Cellular Microbiology. 10: 557-65. PMID 18081726 DOI: 10.1111/J.1462-5822.2007.01109.X |
0.475 |
|
| 2007 |
Liverman ADB, Cheng HC, Trosky JE, Leung DW, Yarbrough ML, Burdette DL, Rosen MK, Orth K. Arp2/3-independent assembly of actin by Vibrio type III effector VopL Proceedings of the National Academy of Sciences of the United States of America. 104: 17117-17122. PMID 17942696 DOI: 10.1073/Pnas.0703196104 |
0.739 |
|
| 2007 |
Trosky JE, Li Y, Mukherjee S, Keitany G, Ball H, Orth K. VopA inhibits ATP binding by acetylating the catalytic loop of MAPK kinases. The Journal of Biological Chemistry. 282: 34299-305. PMID 17881352 DOI: 10.1074/Jbc.M706970200 |
0.322 |
|
| 2007 |
Mukherjee S, Hao YH, Orth K. A newly discovered post-translational modification--the acetylation of serine and threonine residues. Trends in Biochemical Sciences. 32: 210-6. PMID 17412595 DOI: 10.1016/J.Tibs.2007.03.007 |
0.35 |
|
| 2007 |
Chosed R, Tomchick DR, Brautigam CA, Mukherjee S, Negi VS, Machius M, Orth K. Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases. The Journal of Biological Chemistry. 282: 6773-82. PMID 17204475 DOI: 10.1074/Jbc.M608730200 |
0.317 |
|
| 2007 |
Orth K, Caruth W. Versatile Type III Effector Mechanisms Can Disrupt Target-Cell Functions Microbe Magazine. 2: 183-186. DOI: 10.1128/Microbe.2.183.1 |
0.452 |
|
| 2006 |
Fehr D, Casanova C, Liverman A, Blazkova H, Orth K, Dobbelaere D, Frey J, Burr SE. AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-kappaB signalling pathway. Microbiology (Reading, England). 152: 2809-18. PMID 16946275 DOI: 10.1099/Mic.0.28889-0 |
0.414 |
|
| 2006 |
Chosed R, Mukherjee S, Lois LM, Orth K. Evolution of a signalling system that incorporates both redundancy and diversity: Arabidopsis SUMOylation. The Biochemical Journal. 398: 521-9. PMID 16740136 DOI: 10.1042/Bj20060426 |
0.384 |
|
| 2006 |
Mukherjee S, Keitany G, Li Y, Wang Y, Ball HL, Goldsmith EJ, Orth K. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science (New York, N.Y.). 312: 1211-4. PMID 16728640 DOI: 10.1126/Science.1126867 |
0.408 |
|
| 2004 |
Trosky JE, Mukherjee S, Burdette DL, Roberts M, McCarter L, Siegel RM, Orth K. Inhibition of MAPK signaling pathways by VopA from Vibrio parahaemolyticus. The Journal of Biological Chemistry. 279: 51953-7. PMID 15459200 DOI: 10.1074/Jbc.M407001200 |
0.771 |
|
| 2003 |
Yoon S, Liu Z, Eyobo Y, Orth K. Yersinia effector YopJ inhibits yeast MAPK signaling pathways by an evolutionarily conserved mechanism. The Journal of Biological Chemistry. 278: 2131-5. PMID 12433923 DOI: 10.1074/Jbc.M209905200 |
0.365 |
|
| 2002 |
Heussler VT, Rottenberg S, Schwab R, Küenzi P, Fernandez PC, McKellar S, Shiels B, Chen ZJ, Orth K, Wallach D, Dobbelaere DA. Hijacking of host cell IKK signalosomes by the transforming parasite Theileria. Science (New York, N.Y.). 298: 1033-6. PMID 12411708 DOI: 10.1126/Science.1075462 |
0.393 |
|
| 2002 |
Collier-Hyams LS, Zeng H, Sun J, Tomlinson AD, Bao ZQ, Chen H, Madara JL, Orth K, Neish AS. Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway. Journal of Immunology (Baltimore, Md. : 1950). 169: 2846-50. PMID 12218096 DOI: 10.4049/Jimmunol.169.6.2846 |
0.466 |
|
| 2002 |
Orth K. Function of the Yersinia effector YopJ. Current Opinion in Microbiology. 5: 38-43. PMID 11834367 DOI: 10.1016/S1369-5274(02)00283-7 |
0.454 |
|
| 2002 |
Orth K, Dixon JE, Bliska JB. 20 Effector proteins of bacterial type III protein secretion systems: Elucidating their biochemical effects on eukaryotic signaling cascades Methods in Microbiology. 31: 361-376. DOI: 10.1016/S0580-9517(02)31021-3 |
0.613 |
|
| 2001 |
Abe MK, Kahle KT, Saelzler MP, Orth K, Dixon JE, Rosner MR. ERK7 is an autoactivated member of the MAPK family. The Journal of Biological Chemistry. 276: 21272-9. PMID 11287416 DOI: 10.1074/Jbc.M100026200 |
0.53 |
|
| 2000 |
Orth K, Xu Z, Mudgett MB, Bao ZQ, Palmer LE, Bliska JB, Mangel WF, Staskawicz B, Dixon JE. Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease. Science (New York, N.Y.). 290: 1594-7. PMID 11090361 DOI: 10.1126/Science.290.5496.1594 |
0.581 |
|
| 2000 |
Juris SJ, Rudolph AE, Huddler D, Orth K, Dixon JE. A distinctive role for the Yersinia protein kinase: actin binding, kinase activation, and cytoskeleton disruption. Proceedings of the National Academy of Sciences of the United States of America. 97: 9431-6. PMID 10920208 DOI: 10.1073/Pnas.170281997 |
0.577 |
|
| 1999 |
Orth K, Palmer LE, Bao ZQ, Stewart S, Rudolph AE, Bliska JB, Dixon JE. Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector Science. 285: 1920-1923. PMID 10489373 DOI: 10.1126/Science.285.5435.1920 |
0.602 |
|
| 1997 |
Wen LP, Fahrni JA, Troie S, Guan JL, Orth K, Rosen GD. Cleavage of focal adhesion kinase by caspases during apoptosis. The Journal of Biological Chemistry. 272: 26056-61. PMID 9325343 DOI: 10.1074/Jbc.272.41.26056 |
0.35 |
|
| 1997 |
Orth K, Dixit VM. Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis Journal of Biological Chemistry. 272: 8841-8844. PMID 9082997 DOI: 10.1074/Jbc.272.14.8841 |
0.317 |
|
| 1996 |
Chinnaiyan AM, Hanna WL, Orth K, Duan H, Poirier GG, Froelich CJ, Dixit VM. Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3. Current Biology : Cb. 6: 897-9. PMID 8805307 DOI: 10.1016/S0960-9822(02)00614-0 |
0.32 |
|
| 1992 |
Orth K, Madison EL, Gething MJ, Sambrook JF, Herz J. Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 89: 7422-6. PMID 1502153 DOI: 10.1073/Pnas.89.16.7422 |
0.333 |
|
| 1991 |
Letsou A, Alexander S, Orth K, Wasserman SA. Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity. Proceedings of the National Academy of Sciences of the United States of America. 88: 810-4. PMID 1899484 DOI: 10.1073/Pnas.88.3.810 |
0.333 |
|
| 1991 |
Hagen FS, Grant FJ, Kuijper JL, Slaughter CA, Moomaw CR, Orth K, O'Hara PJ, Munford RS. Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides. Biochemistry. 30: 8415-23. PMID 1883828 DOI: 10.1021/Bi00098A020 |
0.325 |
|
| 1988 |
Gil G, Smith JR, Goldstein JL, Slaughter CA, Orth K, Brown MS, Osborne TF. Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proceedings of the National Academy of Sciences of the United States of America. 85: 8963-7. PMID 3194401 DOI: 10.1073/Pnas.85.23.8963 |
0.342 |
|
| 1986 |
Peterson CL, Orth K, Calame KL. Binding in vitro of multiple cellular proteins to immunoglobulin heavy-chain enhancer DNA. Molecular and Cellular Biology. 6: 4168-78. PMID 3025641 DOI: 10.1128/Mcb.6.12.4168 |
0.344 |
|
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