| Year |
Citation |
Score |
| 2021 |
Madjroh N, Davies PA, Smalley JL, Kristiansen U, Söderhielm PC, Jensen AA. Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency ThrAla variant (rs2257020) in Xenopus oocytes. Pharmacological Research. 105653. PMID 33962015 DOI: 10.1016/j.phrs.2021.105653 |
0.328 |
|
| 2020 |
Falk-Petersen CB, Tsonkov TM, Nielsen MS, Harpsøe K, Bundgaard C, Frølund B, Kristiansen U, Gloriam DE, Wellendorph P. Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA receptors. Scientific Reports. 10: 10078. PMID 32572053 DOI: 10.1038/S41598-020-66821-0 |
0.503 |
|
| 2017 |
von Schoubye NL, Frederiksen K, Kristiansen U, Petersen AV, Dalby NO, Grunnet M, Jensen HS, Jespersen T, Sohal VS, Perrier JF. The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6(+/-) mice. Neuroscience Letters. PMID 28987817 DOI: 10.1016/J.Neulet.2017.10.004 |
0.611 |
|
| 2017 |
Simonsen C, Boddum K, von Schoubye NL, Kloppenburg A, Sønderskov K, Hansen SL, Kristiansen U. Anticonvulsive evaluation of THIP in the murine pentylenetetrazole kindling model: lack of anticonvulsive effect of THIP despite functional δ-subunit-containing GABAA receptors in dentate gyrus granule cells. Pharmacology Research & Perspectives. 5. PMID 28805971 DOI: 10.1002/Prp2.322 |
0.613 |
|
| 2016 |
Boddum K, Jensen TP, Magloire V, Kristiansen U, Rusakov DA, Pavlov I, Walker MC. Astrocytic GABA transporter activity modulates excitatory neurotransmission. Nature Communications. 7: 13572. PMID 27886179 DOI: 10.1038/Ncomms13572 |
0.71 |
|
| 2016 |
Gasiorek A, Trattnig SM, Ahring PK, Kristiansen U, Frølund B, Frederiksen K, Jensen AA. Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 receptors. Biochemical Pharmacology. 110: 92-108. PMID 27086281 DOI: 10.1016/J.Bcp.2016.04.004 |
0.414 |
|
| 2015 |
Krall J, Balle T, Krogsgaard-Larsen N, Sørensen TE, Krogsgaard-Larsen P, Kristiansen U, Frølund B. GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology. Advances in Pharmacology (San Diego, Calif.). 72: 201-27. PMID 25600372 DOI: 10.1016/Bs.Apha.2014.10.003 |
0.468 |
|
| 2014 |
Boddum K, Frølund B, Kristiansen U. The GABAA antagonist DPP-4-PIOL selectively antagonises tonic over phasic GABAergic currents in dentate gyrus granule cells. Neurochemical Research. 39: 2078-84. PMID 25103229 DOI: 10.1007/S11064-014-1397-9 |
0.746 |
|
| 2014 |
Laursen B, Mørk A, Plath N, Kristiansen U, Bastlund JF. Impaired hippocampal acetylcholine release parallels spatial memory deficits in Tg2576 mice subjected to basal forebrain cholinergic degeneration. Brain Research. 1543: 253-62. PMID 24231553 DOI: 10.1016/J.Brainres.2013.10.055 |
0.324 |
|
| 2014 |
Kjaerby C, Broberg BV, Kristiansen U, Dalby NO. Impaired GABAergic inhibition in the prefrontal cortex of early postnatal phencyclidine (PCP)-treated rats. Cerebral Cortex (New York, N.Y. : 1991). 24: 2522-32. PMID 23613110 DOI: 10.1093/Cercor/Bht109 |
0.477 |
|
| 2013 |
Hoestgaard-Jensen K, O'Connor RM, Dalby NO, Simonsen C, Finger BC, Golubeva A, Hammer H, Bergmann ML, Kristiansen U, Krogsgaard-Larsen P, Bräuner-Osborne H, Ebert B, Frølund B, Cryan JF, Jensen AA. The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors. British Journal of Pharmacology. 170: 919-32. PMID 23957253 DOI: 10.1111/Bph.12340 |
0.502 |
|
| 2013 |
Kjaerby C, Bundgaard C, Fejgin K, Kristiansen U, Dalby NO. Repeated potentiation of the metabotropic glutamate receptor 5 and the alpha 7 nicotinic acetylcholine receptor modulates behavioural and GABAergic deficits induced by early postnatal phencyclidine (PCP) treatment. Neuropharmacology. 72: 157-68. PMID 23643744 DOI: 10.1016/J.Neuropharm.2013.04.041 |
0.514 |
|
| 2013 |
Petersen JG, Bergmann R, Møller HA, Jørgensen CG, Nielsen B, Kehler J, Frydenvang K, Kristensen J, Balle T, Jensen AA, Kristiansen U, Frølund B. Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as γ-aminobutyric acid(a) receptor agonists. Journal of Medicinal Chemistry. 56: 993-1006. PMID 23294161 DOI: 10.1021/Jm301473K |
0.462 |
|
| 2013 |
Laursen B, Mørk A, Plath N, Kristiansen U, Bastlund JF. Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice. Behavioural Brain Research. 240: 146-52. PMID 23178660 DOI: 10.1016/J.Bbr.2012.11.012 |
0.314 |
|
| 2013 |
Kohlmeier KA, Christensen MH, Kristensen MP, Kristiansen U. Pharmacological evidence of functional inhibitory metabotrophic glutamate receptors on mouse arousal-related cholinergic laterodorsal tegmental neurons. Neuropharmacology. 66: 99-113. PMID 22381584 DOI: 10.1016/J.Neuropharm.2012.02.016 |
0.434 |
|
| 2012 |
Hansen SL, Sterjev Z, Werngreen M, Simonsen BJ, Knudsen KE, Nielsen AH, Pedersen ME, Badolo L, Kristiansen U, Vestergaard HT. Does brain slices from pentylenetetrazole-kindled mice provide a more predictive screening model for antiepileptic drugs? European Journal of Pharmacology. 682: 43-49. PMID 22366211 DOI: 10.1016/J.Ejphar.2012.01.044 |
0.304 |
|
| 2010 |
Kohlmeier KA, Kristiansen U. GABAergic actions on cholinergic laterodorsal tegmental neurons: implications for control of behavioral state. Neuroscience. 171: 812-29. PMID 20884335 DOI: 10.1016/J.Neuroscience.2010.09.034 |
0.515 |
|
| 2009 |
Hansen SL, Nielsen AH, Knudsen KE, Artmann A, Petersen G, Kristiansen U, Hansen SH, Hansen HS. Ketogenic diet is antiepileptogenic in pentylenetetrazole kindled mice and decrease levels of N-acylethanolamines in hippocampus Neurochemistry International. 54: 199-204. PMID 19100800 DOI: 10.1016/J.Neuint.2008.10.012 |
0.374 |
|
| 2007 |
Madsen C, Jensen AA, Liljefors T, Kristiansen U, Nielsen B, Hansen CP, Larsen M, Ebert B, Bang-Andersen B, Krogsgaard-Larsen P, Frølund B. 5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists. Journal of Medicinal Chemistry. 50: 4147-61. PMID 17655213 DOI: 10.1021/Jm070447J |
0.473 |
|
| 2007 |
Jensen AA, Begum N, Vogensen SB, Knapp KM, Gundertofte K, Dzyuba SV, Ishii H, Nakanishi K, Kristiansen U, Strømgaard K. Probing the pharmacophore of ginkgolides as glycine receptor antagonists. Journal of Medicinal Chemistry. 50: 1610-7. PMID 17352465 DOI: 10.1021/Jm070003N |
0.473 |
|
| 2007 |
Vestergaard HT, Cannillo C, Frølund B, Kristiansen U. Differences in kinetics of structurally related competitive GABA(A) receptor antagonists. Neuropharmacology. 52: 873-82. PMID 17125806 DOI: 10.1016/J.Neuropharm.2006.10.004 |
0.504 |
|
| 2006 |
Lolli ML, Hansen SL, Rolando B, Nielsen B, Wellendorph P, Madsen K, Larsen OM, Kristiansen U, Fruttero R, Gasco A, Johansen TN. Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of γ-aminobutyric acid (GABA) related compounds Journal of Medicinal Chemistry. 49: 4442-4446. PMID 16821803 DOI: 10.1021/Jm051288B |
0.453 |
|
| 2005 |
Frølund B, Jensen LS, Guandalini L, Canillo C, Vestergaard HT, Kristiansen U, Nielsen B, Stensbøl TB, Madsen C, Krogsgaard-Larsen P, Liljefors T. Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. Journal of Medicinal Chemistry. 48: 427-39. PMID 15658856 DOI: 10.1021/Jm049256W |
0.452 |
|
| 2004 |
Jensen AA, Kristiansen U. Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay. Biochemical Pharmacology. 67: 1789-99. PMID 15081878 DOI: 10.1016/J.Bcp.2003.12.037 |
0.382 |
|
| 2004 |
Mortensen M, Kristiansen U, Ebert B, Frølund B, Krogsgaard-Larsen P, Smart TG. Activation of single heteromeric GABA(A) receptor ion channels by full and partial agonists. The Journal of Physiology. 557: 389-413. PMID 14990676 DOI: 10.1113/Jphysiol.2003.054734 |
0.499 |
|
| 2003 |
Frølund B, Tagmose L, Jørgensen AT, Kristiansen U, Stensbøl TB, Liljefors T, Krogsgaard-Larsen P. Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABA A antagonists. European Journal of Medicinal Chemistry. 38: 447-9. PMID 12750034 DOI: 10.1016/S0223-5234(03)00056-4 |
0.477 |
|
| 2003 |
Engblom AC, Johansen FF, Kristiansen U. Actions and interactions of extracellular potassium and kainate on expression of 13 gamma-aminobutyric acid type A receptor subunits in cultured mouse cerebellar granule neurons. The Journal of Biological Chemistry. 278: 16543-50. PMID 12621038 DOI: 10.1074/Jbc.M300548200 |
0.376 |
|
| 2002 |
Frølund B, Ebert B, Kristiansen U, Liljefors T, Krogsgaard-Larsen P. GABA(A) receptor ligands and their therapeutic potentials. Current Topics in Medicinal Chemistry. 2: 817-32. PMID 12171573 DOI: 10.2174/1568026023393525 |
0.489 |
|
| 2002 |
Frølund B, Jørgensen AT, Tagmose L, Stensbøl TB, Vestergaard HT, Engblom C, Kristiansen U, Sanchez C, Krogsgaard-Larsen P, Liljefors T. Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. Journal of Medicinal Chemistry. 45: 2454-68. PMID 12036354 DOI: 10.1021/Jm020027O |
0.486 |
|
| 2002 |
Engblom AC, Carlson BX, Olsen RW, Schousboe A, Kristiansen U. Point mutation in the first transmembrane region of the beta 2 subunit of the gamma--aminobutyric acid type A receptor alters desensitization kinetics of gamma--aminobutyric acid- and anesthetic-induced channel gating. The Journal of Biological Chemistry. 277: 17438-47. PMID 11877425 DOI: 10.1074/jbc.M111215200 |
0.321 |
|
| 2001 |
Hansen SL, Ebert B, Fjalland B, Kristiansen U. Effects of GABA A receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions British Journal of Pharmacology. 133: 539-549. PMID 11399671 DOI: 10.1038/Sj.Bjp.0704121 |
0.51 |
|
| 2001 |
Alsbo CW, Kristiansen U, Møller F, Hansen SL, Johansen FF. GABAA receptor subunit interactions important for benzodiazepine and zinc modulation: A patch-clamp and single cell RT-PCR study European Journal of Neuroscience. 13: 1673-1682. PMID 11359519 DOI: 10.1046/J.0953-816X.2001.01539.X |
0.398 |
|
| 2001 |
Elster L, Kristiansen U, Pickering DS, Olsen RW, Schousboe A. Molecular determinants of desensitization and assembly of the chimeric GABAA receptor subunits (α1/γ2) and (γ2/α1) in combinations with β2 and γ2 Neurochemistry International. 38: 581-592. PMID 11290383 DOI: 10.1016/S0197-0186(00)00122-4 |
0.355 |
|
| 2001 |
Frølund B, Tagmose L, Liljefors T, Stensbøl TB, Engblom C, Kristiansen U, Krogsgaard-Larsen P. A novel class of potent 3-isoxazolol GABA(A) antagonists: design, synthesis, and pharmacology. Journal of Medicinal Chemistry. 43: 4930-3. PMID 11150163 DOI: 10.1021/Jm000371Q |
0.379 |
|
| 2000 |
Carlson BX, Engblom AC, Kristiansen U, Schousboe A, Olsen RW. A single glycine residue at the entrance to the first membrane-spanning domain of the gamma-aminobutyric acid type A receptor beta(2) subunit affects allosteric sensitivity to GABA and anesthetics. Molecular Pharmacology. 57: 474-84. PMID 10692487 DOI: 10.1124/Mol.57.3.474 |
0.441 |
|
| 1998 |
Elster L, Banke T, Kristiansen U, Schousboe A, Wahl P. Functional properties of glycine receptors expressed in primary cultures of mouse cerebellar granule cells. Neuroscience. 84: 519-28. PMID 9539222 DOI: 10.1016/S0306-4522(97)00535-6 |
0.394 |
|
| 1997 |
Kristiansen U, Lambert JD. Benzodiazepine and barbiturate ligands modulate responses of cultured hippocampal neurones to the GABAA receptor partial agonist, 4-PIOL. Neuropharmacology. 35: 1181-91. PMID 9014133 DOI: 10.1016/S0028-3908(96)00070-6 |
0.333 |
|
| 1997 |
Krogsgaard-Larsen P, Fr∅lund B, Kristiansen U, Frydenvang K, Ebert B. GABAA and GABAB receptor agonists, partial agonists, antagonists and modulators: design and therapeutic prospects European Journal of Pharmaceutical Sciences. 5: 355-384. DOI: 10.1016/S0928-0987(97)10009-4 |
0.489 |
|
| 1997 |
Brehm L, Ebert B, Kristiansen U, Wafford KA, Kemp JA, Krogsgaard-Larsen P. Structure and pharmacology of 4,5,6,7-tetrahydroisothiazolo [5,4-c]pyridin-3-ol (Thio-THIP), an agonist/antagonist at GABA(A) receptors European Journal of Medicinal Chemistry. 32: 357-363. DOI: 10.1016/S0223-5234(97)89089-7 |
0.485 |
|
| 1995 |
Frølund B, Kristiansen U, Brehm L, Hansen AB, Krogsgaard-Larsen P, Falch E. Partial GABAA receptor agonists. Synthesis and in vitro pharmacology of a series of nonannulated analogs of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol. Journal of Medicinal Chemistry. 38: 3287-96. PMID 7650683 DOI: 10.1021/Jm00017A014 |
0.453 |
|
| 1995 |
Frydenvang K, Kristiansen U, Frølund B, Herdeis C, Krogsgaard-Larsen P. GABABantagonists: Enantiopharmacology of 5-amino-4-hydroxy-2-methylvaleric acid and X-ray structure of the eutomer Chirality. 7: 526-533. DOI: 10.1002/Chir.530070706 |
0.383 |
|
| 1992 |
Kristiansen U, Lambert JD, Falch E, Krogsgaard-Larsen P. Electrophysiological studies of the GABAA receptor ligand, 4-PIOL, on cultured hippocampal neurones. British Journal of Pharmacology. 104: 85-90. PMID 1664767 DOI: 10.1111/J.1476-5381.1991.Tb12389.X |
0.44 |
|
| 1992 |
Kristiansen U, Hedegaard A, Herdeis C, Lund TM, Nielsen B, Hansen JJ, Falch E, Hjeds H, Krogsgaard-Larsen P. Hydroxylated analogues of 5-aminovaleric acid as 4-aminobutyric acidB receptor antagonists: stereostructure-activity relationships. Journal of Neurochemistry. 58: 1150-9. PMID 1310720 DOI: 10.1111/J.1471-4159.1992.Tb09374.X |
0.441 |
|
| 1991 |
Kristiansen U, Fjalland B. Ligand structural specificity of GABAA receptors in guinea pig ileum. Pharmacology & Toxicology. 68: 332-9. PMID 1658764 DOI: 10.1111/J.1600-0773.1991.TB01249.X |
0.302 |
|
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