Frank Heppner - Publications

Affiliations: 
Neuropathology Charité - Universitätsmedizin Berlin, Germany 

58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Drost N, Houtman J, Cseresnyés Z, Niesner R, Rinnenthal JL, Miller KR, Prokop S, Heppner FL. The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin. Scientific Reports. 10: 7152. PMID 32346002 DOI: 10.1038/S41598-020-63989-3  0.795
2020 Eede P, Obst J, Benke E, Yvon-Durocher G, Richard BC, Gimber N, Schmoranzer J, Böddrich A, Wanker EE, Prokop S, Heppner FL. Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice. Embo Reports. e48530. PMID 32003148 DOI: 10.15252/Embr.201948530  0.65
2018 Kälin S, Miller KR, Kälin RE, Jendrach M, Witzel C, Heppner FL. CNS myeloid cells critically regulate heat hyperalgesia. The Journal of Clinical Investigation. PMID 29634489 DOI: 10.1172/Jci95305  0.655
2017 Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, ... ... Heppner FL, et al. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 47: 566-581.e9. PMID 28930663 DOI: 10.1016/J.Immuni.2017.08.008  0.795
2017 Wagner LK, Gilling KE, Schormann E, Kloetzel PM, Heppner FL, Krüger E, Prokop S. Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer's disease-like APPPS1 mice. Acta Neuropathologica Communications. 5: 52. PMID 28646899 DOI: 10.1186/S40478-017-0453-5  0.66
2016 Baufeld C, Osterloh A, Prokop S, Miller KR, Heppner FL. High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia. Acta Neuropathologica. PMID 27393312 DOI: 10.1007/S00401-016-1595-4  0.779
2016 Brandenburg S, Müller A, Turkowski K, Radev YT, Rot S, Schmidt C, Bungert AD, Acker G, Schorr A, Hippe A, Miller K, Heppner FL, Homey B, Vajkoczy P. Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors. Acta Neuropathologica. 131: 365-78. PMID 26718201 DOI: 10.1007/S00401-015-1529-6  0.674
2015 Prokop S, Miller KR, Drost N, Handrick S, Mathur V, Luo J, Wegner A, Wyss-Coray T, Heppner FL. Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice. The Journal of Experimental Medicine. 212: 1811-8. PMID 26458768 DOI: 10.1084/Jem.20150479  0.794
2015 Schreiner B, Romanelli E, Liberski P, Ingold-Heppner B, Sobottka-Brillout B, Hartwig T, Chandrasekar V, Johannssen H, Zeilhofer HU, Aguzzi A, Heppner F, Kerschensteiner M, Becher B. Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS. Cell Reports. 12: 1377-84. PMID 26299968 DOI: 10.1016/J.Celrep.2015.07.051  0.525
2015 Naumann RK, Ray S, Prokop S, Las L, Heppner FL, Brecht M. Conserved size & periodicity of pyramidal patches in layer 2 of medial/caudal entorhinal cortex. The Journal of Comparative Neurology. PMID 26223342 DOI: 10.1002/Cne.23865  0.618
2015 Nunes JC, Radbruch H, Walz R, Lin K, Stenzel W, Prokop S, Koch A, Heppner FL. The most fulminant course of the Marburg variant of multiple sclerosis-autopsy findings. Multiple Sclerosis (Houndmills, Basingstoke, England). 21: 485-7. PMID 25824955 DOI: 10.1177/1352458514537366  0.633
2015 Johansson LB, Simon R, Bergström G, Eriksson M, Prokop S, Mandenius CF, Heppner FL, Åslund AK, Nilsson KP. An azide functionalized oligothiophene ligand--a versatile tool for multimodal detection of disease associated protein aggregates. Biosensors & Bioelectronics. 63: 204-11. PMID 25089818 DOI: 10.1016/J.Bios.2014.07.042  0.624
2014 Barucker C, Harmeier A, Weiske J, Fauler B, Albring KF, Prokop S, Hildebrand P, Lurz R, Heppner FL, Huber O, Multhaup G. Nuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription. The Journal of Biological Chemistry. 289: 20182-91. PMID 24878959 DOI: 10.1074/Jbc.M114.564690  0.654
2014 Schröder NW, Grieben U, Prokop S, Dekomien G, Epplen JT, Heppner FL, Goebel HH, Stenzel W. Novel γ-sarcoglycan-mutation affects cardiac function and N-terminal dystrophin expression. Muscle & Nerve. 49: 144-5. PMID 23929688 DOI: 10.1002/Mus.23981  0.618
2013 Prokop S, Miller KR, Heppner FL. Microglia actions in Alzheimer’s disease. Acta Neuropathologica. 126: 461-77. PMID 24224195 DOI: 10.1007/S00401-013-1182-X  0.799
2013 Krabbe G, Halle A, Matyash V, Rinnenthal JL, Eom GD, Bernhardt U, Miller KR, Prokop S, Kettenmann H, Heppner FL. Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology. Plos One. 8: e60921. PMID 23577177 DOI: 10.1371/Journal.Pone.0060921  0.792
2013 Nyström S, Psonka-Antonczyk KM, Ellingsen PG, Johansson LB, Reitan N, Handrick S, Prokop S, Heppner FL, Wegenast-Braun BM, Jucker M, Lindgren M, Stokke BT, Hammarström P, Nilsson KP. Evidence for age-dependent in vivo conformational rearrangement within Aβ amyloid deposits. Acs Chemical Biology. 8: 1128-33. PMID 23521783 DOI: 10.1021/Cb4000376  0.65
2013 Arja K, Sjölander D, Ã…slund A, Prokop S, Heppner FL, Konradsson P, Lindgren M, Hammarström P, Ã…slund KO, Nilsson KP. Enhanced fluorescent assignment of protein aggregates by an oligothiophene-porphyrin-based amyloid ligand. Macromolecular Rapid Communications. 34: 723-30. PMID 23468206 DOI: 10.1002/Marc.201200817  0.644
2013 Klingstedt T, Blechschmidt C, Nogalska A, Prokop S, Häggqvist B, Danielsson O, Engel WK, Askanas V, Heppner FL, Nilsson KP. Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies. Chembiochem : a European Journal of Chemical Biology. 14: 607-16. PMID 23450708 DOI: 10.1002/Cbic.201200731  0.625
2012 Vom Berg J, Prokop S, Miller KR, Obst J, Kälin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O, Winter Y, Becher B, Heppner FL. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nature Medicine. 18: 1812-9. PMID 23178247 DOI: 10.1038/Nm.2965  0.772
2012 Varvel NH, Grathwohl SA, Baumann F, Liebig C, Bosch A, Brawek B, Thal DR, Charo IF, Heppner FL, Aguzzi A, Garaschuk O, Ransohoff RM, Jucker M. Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 18150-5. PMID 23071306 DOI: 10.1073/Pnas.1210150109  0.589
2012 Gertz K, Kronenberg G, Kälin RE, Baldinger T, Werner C, Balkaya M, Eom GD, Hellmann-Regen J, Kröber J, Miller KR, Lindauer U, Laufs U, Dirnagl U, Heppner FL, Endres M. Essential role of interleukin-6 in post-stroke angiogenesis. Brain : a Journal of Neurology. 135: 1964-80. PMID 22492561 DOI: 10.1093/Brain/Aws075  0.649
2012 Obst J, Prokop S, vom Berg J, Miller K, Kälin R, Lopategui-Cabezas I, Wegner A, Mair F, Winter Y, Becher B, Heppner FL. P4-337: Reducing Alzheimer's disease beta-amyloid and cognitive deficits by manipulating il-12/il-23 signaling Alzheimer's & Dementia. 8: S776-S777. DOI: 10.1016/J.Jalz.2013.08.118  0.757
2012 Eom G, Prokop S, Heppner FL. P4-287: The role of microglia in BETA-AMYLOID immunotherapy Alzheimer's & Dementia. 8: S759-S759. DOI: 10.1016/J.Jalz.2013.08.068  0.618
2011 Opitz E, Koch A, Klingel K, Schmidt F, Prokop S, Rahnefeld A, Sauter M, Heppner FL, Völker U, Kandolf R, Kuckelkorn U, Stangl K, Krüger E, Kloetzel PM, Voigt A. Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis. Plos Pathogens. 7: e1002233. PMID 21909276 DOI: 10.1371/Journal.Ppat.1002233  0.661
2011 Schipke CG, Jessen F, Teipel S, Luckhaus C, Wiltfang J, Esselmann H, Frölich L, Maier W, Rüther E, Heppner FL, Prokop S, Heuser I, Peters O. Long-term stability of Alzheimer's disease biomarker proteins in cerebrospinal fluid. Journal of Alzheimer's Disease : Jad. 26: 255-62. PMID 21606567 DOI: 10.3233/Jad-2011-110329  0.63
2011 Prokop S, Heppner FL, Goebel HH, Stenzel W. M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosis. The American Journal of Pathology. 178: 1279-86. PMID 21356378 DOI: 10.1016/J.Ajpath.2010.11.065  0.661
2010 Stenzel W, Prokop S, Kress W, Huppmann S, Loui A, Sarioglu NM, Laing NG, Sparrow JC, Heppner FL, Goebel HH. Fetal akinesia caused by a novel actin filament aggregate myopathy skeletal muscle actin gene (ACTA1) mutation. Neuromuscular Disorders : Nmd. 20: 531-3. PMID 20621480 DOI: 10.1016/J.Nmd.2010.06.008  0.594
2010 Mirrione MM, Konomos DK, Gravanis I, Dewey SL, Aguzzi A, Heppner FL, Tsirka SE. Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice Neurobiology of Disease. 39: 85-97. PMID 20382223 DOI: 10.1016/J.Nbd.2010.04.001  0.52
2010 Peters O, Prokop S, Heppner F, Heuser I, Schipke CG. P3-167: Determination of long-term stability of A-beta species in human cerebrospinal fluid using different methods Alzheimer's & Dementia. 6: S498-S498. DOI: 10.1016/J.Jalz.2010.05.1665  0.618
2009 Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, et al. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nature Neuroscience. 12: 1361-3. PMID 19838177 DOI: 10.1515/Nf-2010-0107  0.74
2009 Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, et al. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. Acs Chemical Biology. 4: 673-84. PMID 19624097 DOI: 10.1021/Cb900112V  0.735
2008 Steele AD, Hutter G, Jackson WS, Heppner FL, Borkowski AW, King OD, Raymond GJ, Aguzzi A, Lindquist S. Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 13626-31. PMID 18757733 DOI: 10.1073/Pnas.0806319105  0.567
2008 Falsig J, Julius C, Margalith I, Schwarz P, Heppner FL, Aguzzi A. A versatile prion replication assay in organotypic brain slices. Nature Neuroscience. 11: 109-17. PMID 18066056 DOI: 10.1038/Nn2028  0.552
2007 Aguzzi A, Heppner FL, Westner IM, Glatzel M. Prion diseases Neurobiology of Disease. 473-483. DOI: 10.1016/B978-012088592-3/50044-X  0.563
2006 Priller J, Prinz M, Heikenwalder M, Zeller N, Schwarz P, Heppner FL, Aguzzi A. Early and rapid engraftment of bone marrow-derived microglia in scrapie. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11753-62. PMID 17093096 DOI: 10.1523/Jneurosci.2275-06.2006  0.594
2005 Donofrio G, Heppner FL, Polymenidou M, Musahl C, Aguzzi A. Paracrine inhibition of prion propagation by anti-PrP single-chain Fv miniantibodies. Journal of Virology. 79: 8330-8. PMID 15956578 DOI: 10.1128/Jvi.79.13.8330-8338.2005  0.554
2005 Nikles D, Bach P, Boller K, Merten CA, Montrasio F, Heppner FL, Aguzzi A, Cichutek K, Kalinke U, Buchholz CJ. Circumventing tolerance to the prion protein (PrP): vaccination with PrP-displaying retrovirus particles induces humoral immune responses against the native form of cellular PrP. Journal of Virology. 79: 4033-42. PMID 15767405 DOI: 10.1128/Jvi.79.7.4033-4042.2005  0.563
2005 Heppner FL, Greter M, Marino D, Falsig J, Raivich G, Hövelmeyer N, Waisman A, Rülicke T, Prinz M, Priller J, Becher B, Aguzzi A. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nature Medicine. 11: 146-52. PMID 15665833 DOI: 10.1038/Nm1177  0.575
2005 Heppner FL, Greter M, Marino D, Falsig J, Raivich G, Hövelmeyer N, Waisman A, Rülicke T, Prinz M, Priller J, Becher B, Aguzzi A. Erratum: CORRIGENDUM: Experimental autoimmune encephalomyelitis repressed by microglial paralysis Nature Medicine. 11: 455-455. DOI: 10.1038/Nm0405-455  0.498
2004 Heppner FL, Aguzzi A. Recent developments in prion immunotherapy. Current Opinion in Immunology. 16: 594-8. PMID 15342005 DOI: 10.1016/J.Coi.2004.07.008  0.574
2004 Polymenidou M, Heppner FL, Pellicioli EC, Urich E, Miele G, Braun N, Wopfner F, Schätzl HM, Becher B, Aguzzi A. Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection. Proceedings of the National Academy of Sciences of the United States of America. 101: 14670-6. PMID 15292505 DOI: 10.1073/Pnas.0404772101  0.553
2004 Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, Hyslop PS, Holtzman DM, Walker LC, Keller ET. Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta). Alzheimer Disease and Associated Disorders. 18: 44-6. PMID 15195463 DOI: 10.1097/00002093-200401000-00009  0.51
2004 Heikenwalder M, Prinz M, Heppner FL, Aguzzi A. Current concepts and controversies in prion immunopathology. Journal of Molecular Neuroscience : Mn. 23: 3-12. PMID 15126687 DOI: 10.1385/Jmn:23:1-2:003  0.564
2004 Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, St George Hyslop P, Holtzman DM, Walker LC, Keller ET. Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta). Mechanisms of Ageing and Development. 125: 149-51. PMID 15037022 DOI: 10.1016/J.Mad.2003.12.002  0.52
2004 Genoud N, Behrens A, Miele G, Robay D, Heppner FL, Freigang S, Aguzzi A. Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions. Proceedings of the National Academy of Sciences of the United States of America. 101: 4198-203. PMID 15007175 DOI: 10.1073/Pnas.0400131101  0.561
2003 Prinz M, Heikenwalder M, Junt T, Schwarz P, Glatzel M, Heppner FL, Fu YX, Lipp M, Aguzzi A. Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion. Nature. 425: 957-62. PMID 14562059 DOI: 10.1038/Nature02072  0.568
2003 Aguzzi A, Heppner FL, Heikenwalder M, Prinz M, Mertz K, Seeger H, Glatzel M. Immune system and peripheral nerves in propagation of prions to CNS. British Medical Bulletin. 66: 141-59. PMID 14522856 DOI: 10.1093/Bmb/66.1.141  0.57
2003 Hutter G, Heppner FL, Aguzzi A. No superoxide dismutase activity of cellular prion protein in vivo. Biological Chemistry. 384: 1279-85. PMID 14515989 DOI: 10.1515/Bc.2003.142  0.561
2003 Prinz M, Huber G, Macpherson AJ, Heppner FL, Glatzel M, Eugster HP, Wagner N, Aguzzi A. Oral prion infection requires normal numbers of Peyer's patches but not of enteric lymphocytes. The American Journal of Pathology. 162: 1103-11. PMID 12651603 DOI: 10.1016/S0002-9440(10)63907-7  0.566
2002 Behrens A, Genoud N, Naumann H, Rülicke T, Janett F, Heppner FL, Ledermann B, Aguzzi A. Absence of the prion protein homologue Doppel causes male sterility. The Embo Journal. 21: 3652-8. PMID 12110578 DOI: 10.1093/Emboj/Cdf386  0.552
2002 Heppner FL, Arrighi I, Kalinke U, Aguzzi A. Immunity against prions? Trends in Molecular Medicine. 7: 477-9. PMID 11689311 DOI: 10.1016/S1471-4914(01)02182-7  0.568
2001 Aguzzi A, Glatzel M, Montrasio F, Prinz M, Heppner FL. Interventional strategies against prion diseases. Nature Reviews. Neuroscience. 2: 745-9. PMID 11584312 DOI: 10.1038/35094590  0.562
2001 Heppner FL, Musahl C, Arrighi I, Klein MA, Rülicke T, Oesch B, Zinkernagel RM, Kalinke U, Aguzzi A. Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science (New York, N.Y.). 294: 178-82. PMID 11546838 DOI: 10.1126/Science.1063093  0.563
2001 Heppner FL, Prinz M, Aguzzi A. Pathogenesis of prion diseases: possible implications of microglial cells. Progress in Brain Research. 132: 737-50. PMID 11545032 DOI: 10.1016/S0079-6123(01)32114-3  0.519
2001 Heppner FL, Christ AD, Klein MA, Prinz M, Fried M, Kraenhenbuhl JP, Aguzzi A. Transepithelial prion transport by M cells [1] Nature Medicine. 7: 976-977. PMID 11533681 DOI: 10.1038/Nm0901-976  0.519
2001 Glatzel M, Heppner FL, Albers KM, Aguzzi A. Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion. Neuron. 31: 25-34. PMID 11498048 DOI: 10.1016/S0896-6273(01)00331-2  0.548
2001 Aguzzi A, Brandner S, Fischer MB, Furukawa H, Glatzel M, Hawkins C, Heppner FL, Montrasio F, Navarro B, Parizek P, Pekarik V, Prinz M, Raeber AJ, Röckl C, Klein MA. Spongiform encephalopathies: insights from transgenic models. Advances in Virus Research. 56: 313-52. PMID 11450305 DOI: 10.1016/S0065-3527(01)56032-7  0.576
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