Pamela Metten - Publications

Oregon Health and Science University, Portland, OR 
 Portland VA Medical Center, United States 
behavioral pharmacogenetics, drug abuse

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Crabbe JC, Hack WR, Ozburn AR, Savarese AM, Metten P. Long-term alcohol drinking in High Drinking in the Dark mice is stable for many months and does not show alcohol deprivation effects. Addiction Biology. e13074. PMID 34227188 DOI: 10.1111/adb.13074  1
2021 Jensen BE, Townsley KG, Grigsby KB, Metten P, Chand M, Uzoekwe M, Tran A, Firsick E, LeBlanc K, Crabbe JC, Ozburn AR. Ethanol-Related Behaviors in Mouse Lines Selectively Bred for Drinking to Intoxication. Brain Sciences. 11. PMID 33557285 DOI: 10.3390/brainsci11020189  1
2021 Savarese AM, Ozburn AR, Barkley-Levenson AM, Metten P, Crabbe JC. The impact of Drinking in the Dark (DID) procedural manipulations on ethanol intake in High Drinking in the Dark (HDID) mice. Alcohol (Fayetteville, N.Y.). PMID 33556460 DOI: 10.1016/j.alcohol.2021.02.001  1
2020 Grigsby KB, Savarese AM, Metten P, Mason BJ, Blednov YA, Crabbe JC, Ozburn AR. Effects of Tacrolimus and Other Immune Targeting Compounds on Binge-Like Ethanol Drinking in High Drinking in the Dark Mice. Neuroscience Insights. 15: 2633105520975412. PMID 33294845 DOI: 10.1177/2633105520975412  1
2020 Savarese AM, Ozburn AR, Metten P, Schlumbohm JP, Hack WR, LeMoine K, Hunt H, Hausch F, Bauder M, Crabbe JC. Targeting the glucocorticoid receptor reduces binge-like drinking in High Drinking in the Dark (HDID-1) mice. Alcoholism, Clinical and Experimental Research. PMID 32154593 DOI: 10.1111/Acer.14318  1
2019 Ozburn AR, Metten P, Potretzke S, Townsley KG, Blednov YA, Crabbe JC. Effects of pharmacologically targeting neuroimmune pathways on alcohol drinking in mice selectively bred to drink to intoxication. Alcoholism, Clinical and Experimental Research. PMID 31853996 DOI: 10.1111/Acer.14269  1
2019 Crabbe JC, Metten P, Savarese AM, Ozburn AR, Schlumbohm JP, Spence SE, Hack WR. Ethanol Conditioned Taste Aversion in High Drinking in the Dark Mice. Brain Sciences. 9. PMID 30609665 DOI: 10.3390/Brainsci9010002  1
2018 Iancu OD, Colville A, Wilmot B, Searles R, Darakjian P, Zheng C, McWeeney S, Kawane S, Crabbe JC, Metten P, Oberbeck D, Hitzemann R. Gender Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Non-Coding RNAs. Alcoholism, Clinical and Experimental Research. PMID 29786871 DOI: 10.1111/Acer.13777  1
2017 Metten P, Schlumbohm JP, Huang LC, Greenberg GD, Hack WR, Spence SE, Crabbe JC. An alcohol withdrawal test battery measuring multiple behavioral symptoms in mice. Alcohol (Fayetteville, N.Y.). 68: 19-35. PMID 29427828 DOI: 10.1016/J.Alcohol.2017.08.014  1
2017 Ferguson LB, Ozburn AR, Ponomarev I, Metten P, Reilly M, Crabbe JC, Harris RA, Mayfield RD. Genome-Wide Expression Profiles Drive Discovery of Novel Compounds that Reduce Binge Drinking in Mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29251283 DOI: 10.1038/Npp.2017.301  1
2017 Crabbe JC, Ozburn AR, Metten P, Barkley-Levenson A, Schlumbohm JP, Spence SE, Hack WR, Huang LC. High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking. Pharmacology, Biochemistry, and Behavior. PMID 28827047 DOI: 10.1016/J.Pbb.2017.08.002  1
2017 Hitzemann R, Oberbeck D, Iancu O, Darakjian P, McWeeney S, Spence S, Schlumbohm J, Metten P, Crabbe J. Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID). Alcohol (Fayetteville, N.Y.). PMID 28442218 DOI: 10.1016/J.Alcohol.2017.02.176  0.4
2017 Hitzemann R, Iancu O, Colville A, Darakjian P, Oberbeck D, Walter N, McWeeney S, Zheng C, Daunais J, Crabbe J, Metten P, Grant K. Brain transcriptional changes in the mouse and macaque associated with excessive ethanol consumption Alcohol. 60: 214. DOI: 10.1016/J.Alcohol.2017.02.230  0.4
2016 Crabbe JC, Schlumbohm JP, Hack W, Barkley-Levenson AM, Metten P, Lattal KM. Fear conditioning in mouse lines genetically selected for binge-like ethanol drinking. Alcohol (Fayetteville, N.Y.). 52: 25-32. PMID 27139234 DOI: 10.1016/J.Alcohol.2016.01.004  1
2016 Greenberg GD, Huang LC, Spence SE, Schlumbohm JP, Metten P, Ozburn AR, Crabbe JC. Nest building is a novel method for indexing severity of alcohol withdrawal in mice. Behavioural Brain Research. PMID 26795092 DOI: 10.1016/J.Bbr.2016.01.023  1
2014 Metten P, Iancu OD, Spence SE, Walter NA, Oberbeck D, Harrington CA, Colville A, McWeeney S, Phillips TJ, Buck KJ, Crabbe JC, Belknap JK, Hitzemann RJ. Dual-trait selection for ethanol consumption and withdrawal: genetic and transcriptional network effects. Alcoholism, Clinical and Experimental Research. 38: 2915-24. PMID 25581648 DOI: 10.1111/Acer.12574  1
2014 Bubier JA, Jay JJ, Baker CL, Bergeson SE, Ohno H, Metten P, Crabbe JC, Chesler EJ. Identification of a QTL in Mus musculus for alcohol preference, withdrawal, and Ap3m2 expression using integrative functional genomics and precision genetics. Genetics. 197: 1377-93. PMID 24923803 DOI: 10.1534/Genetics.114.166165  1
2014 Fritz BM, Cordero KA, Barkley-Levenson AM, Metten P, Crabbe JC, Boehm SL. Genetic relationship between predisposition for binge alcohol consumption and blunted sensitivity to adverse effects of alcohol in mice. Alcoholism, Clinical and Experimental Research. 38: 1284-92. PMID 24612020 DOI: 10.1111/Acer.12385  1
2014 Crabbe JC, Metten P, Belknap JK, Spence SE, Cameron AJ, Schlumbohm JP, Huang LC, Barkley-Levenson AM, Ford MM, Phillips TJ. Progress in a replicated selection for elevated blood ethanol concentrations in HDID mice. Genes, Brain, and Behavior. 13: 236-46. PMID 24219304 DOI: 10.1111/Gbb.12105  1
2013 Crabbe JC, Spence SE, Huang LC, Cameron AJ, Schlumbohm JP, Barkley-Levenson AM, Metten P. Ethanol drinking in withdrawal seizure-prone and -resistant selected mouse lines. Alcohol (Fayetteville, N.Y.). 47: 381-9. PMID 23809872 DOI: 10.1016/J.Alcohol.2013.05.002  1
2013 Iancu OD, Oberbeck D, Darakjian P, Metten P, McWeeney S, Crabbe JC, Hitzemann R. Selection for drinking in the dark alters brain gene coexpression networks. Alcoholism, Clinical and Experimental Research. 37: 1295-303. PMID 23550792 DOI: 10.1111/Acer.12100  1
2012 Crabbe JC, Metten P, Huang LC, Schlumbohm JP, Spence SE, Barkley-Levenson AM, Finn DA, Rhodes JS, Cameron AJ. Ethanol Withdrawal-Associated Drinking and Drinking in the Dark: Common and Discrete Genetic Contributions. Addiction Genetics. 1: 3-11. PMID 24533180 DOI: 10.2478/addge-2012-0002,  1
2012 Crabbe JC, Harkness JH, Spence SE, Huang LC, Metten P. Intermittent availability of ethanol does not always lead to elevated drinking in mice. Alcohol and Alcoholism (Oxford, Oxfordshire). 47: 509-17. PMID 22717273 DOI: 10.1093/Alcalc/Ags067  1
2012 Cozzoli DK, Courson J, Caruana AL, Miller BW, Greentree DI, Thompson AB, Wroten MG, Zhang PW, Xiao B, Hu JH, Klugmann M, Metten P, Worley PF, Crabbe JC, Szumlinski KK. Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Alcoholism, Clinical and Experimental Research. 36: 1623-33. PMID 22432643 DOI: 10.1111/J.1530-0277.2012.01776.X  1
2012 Crabbe JC, Kruse LC, Colville AM, Cameron AJ, Spence SE, Schlumbohm JP, Huang LC, Metten P. Ethanol sensitivity in high drinking in the dark selectively bred mice. Alcoholism, Clinical and Experimental Research. 36: 1162-70. PMID 22316249 DOI: 10.1111/J.1530-0277.2012.01735.X  1
2012 Crabbe JC, Colville AM, Kruse LC, Cameron AJ, Spence SE, Schlumbohm JP, Huang LC, Metten P. Ethanol tolerance and withdrawal severity in high drinking in the dark selectively bred mice. Alcoholism, Clinical and Experimental Research. 36: 1152-61. PMID 22309139 DOI: 10.1111/J.1530-0277.2011.01715.X  1
2012 Philibin SD, Cameron AJ, Schlumbohm JP, Metten P, Crabbe JC. Ethanol withdrawal-induced motor impairment in mice. Psychopharmacology. 220: 367-78. PMID 21947288 DOI: 10.1007/S00213-011-2483-1  1
2011 Metten P, Brown LL, Crabbe JC. Limited access ethanol drinking in the dark in adolescent and adult mice. Pharmacology, Biochemistry, and Behavior. 98: 279-85. PMID 21238474 DOI: 10.1016/J.Pbb.2011.01.003  1
2011 Crabbe JC, Spence SE, Brown LL, Metten P. Alcohol preference drinking in a mouse line selectively bred for high drinking in the dark. Alcohol (Fayetteville, N.Y.). 45: 427-40. PMID 21194877 DOI: 10.1016/J.Alcohol.2010.12.001  1
2010 Metten P, Sorensen ML, Cameron AJ, Yu CH, Crabbe JC. Withdrawal severity after chronic intermittent ethanol in inbred mouse strains. Alcoholism, Clinical and Experimental Research. 34: 1552-64. PMID 20586758 DOI: 10.1111/J.1530-0277.2010.01240.X  1
2009 Cozzoli DK, Goulding SP, Zhang PW, Xiao B, Hu JH, Ary AW, Obara I, Rahn A, Abou-Ziab H, Tyrrel B, Marini C, Yoneyama N, Metten P, Snelling C, Dehoff MH, et al. Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 8655-68. PMID 19587272 DOI: 10.1523/Jneurosci.5900-08.2009  1
2009 Crabbe JC, Metten P, Rhodes JS, Yu CH, Brown LL, Phillips TJ, Finn DA. A line of mice selected for high blood ethanol concentrations shows drinking in the dark to intoxication. Biological Psychiatry. 65: 662-70. PMID 19095222 DOI: 10.1016/J.Biopsych.2008.11.002  1
2009 Bohlen M, Cameron A, Metten P, Crabbe JC, Wahlsten D. Calibration of rotational acceleration for the rotarod test of rodent motor coordination. Journal of Neuroscience Methods. 178: 10-4. PMID 19041892 DOI: 10.1016/J.Jneumeth.2008.11.001  1
2009 Metten P, Crabbe JC, Belknap JK. Genetic correlates of morphine withdrawal in 14 inbred mouse strains. Drug and Alcohol Dependence. 99: 123-31. PMID 18774238 DOI: 10.1016/J.Drugalcdep.2008.07.006  1
2008 Belknap JK, Metten P, Beckley EH, Crabbe JC. Multivariate analyses reveal common and drug-specific genetic influences on responses to four drugs of abuse. Trends in Pharmacological Sciences. 29: 537-43. PMID 18774184 DOI: 10.1016/J.Tips.2008.07.010  1
2008 Philibin SD, Cameron AJ, Metten P, Crabbe JC. Motor impairment: a new ethanol withdrawal phenotype in mice. Behavioural Pharmacology. 19: 604-14. PMID 18690115 DOI: 10.1097/Fbp.0B013E32830Ded27  1
2007 Metten P, Buck KJ, Merrill CM, Roberts AJ, Yu CH, Crabbe JC. Use of a novel mouse genotype to model acute benzodiazepine withdrawal. Behavior Genetics. 37: 160-70. PMID 17226103 DOI: 10.1007/S10519-006-9094-3  1
2006 Crabbe JC, Metten P, Ponomarev I, Prescott CA, Wahlsten D. Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains. Behavior Genetics. 36: 536-52. PMID 16619134 DOI: 10.1007/S10519-006-9067-6  1
2006 Hood HM, Metten P, Crabbe JC, Buck KJ. Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11. Genes, Brain, and Behavior. 5: 1-10. PMID 16436183 DOI: 10.1111/J.1601-183X.2005.00122.X  1
2005 Blednov YA, Metten P, Finn DA, Rhodes JS, Bergeson SE, Harris RA, Crabbe JC. Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J mice. Alcoholism, Clinical and Experimental Research. 29: 1949-58. PMID 16340451 DOI: 10.1097/01.Alc.0000187605.91468.17  1
2005 Metten P, Crabbe JC. Alcohol withdrawal severity in inbred mouse (Mus musculus) strains. Behavioral Neuroscience. 119: 911-25. PMID 16187819 DOI: 10.1037/0735-7044.119.4.911  1
2005 Cronise K, Finn DA, Metten P, Crabbe JC. Scheduled access to ethanol results in motor impairment and tolerance in female C57BL/6J mice. Pharmacology, Biochemistry, and Behavior. 81: 943-53. PMID 16099022 DOI: 10.1016/J.Pbb.2005.07.005  1
2005 Crabbe JC, Metten P, Cameron AJ, Wahlsten D. An analysis of the genetics of alcohol intoxication in inbred mice. Neuroscience and Biobehavioral Reviews. 28: 785-802. PMID 15642621 DOI: 10.1016/J.Neubiorev.2004.08.002  1
2004 Kliethermes CL, Metten P, Belknap JK, Buck KJ, Crabbe JC. Selection for pentobarbital withdrawal severity: correlated differences in withdrawal from other sedative drugs. Brain Research. 1009: 17-25. PMID 15120579 DOI: 10.1016/J.Brainres.2004.02.040  1
2004 Metten P, Best KL, Cameron AJ, Saultz AB, Zuraw JM, Yu CH, Wahlsten D, Crabbe JC. Observer-rated ataxia: rating scales for assessment of genetic differences in ethanol-induced intoxication in mice. Journal of Applied Physiology (Bethesda, Md. : 1985). 97: 360-8. PMID 15033960 DOI: 10.1152/Japplphysiol.00086.2004  1
2004 Fehr C, Shirley RL, Metten P, Kosobud AE, Belknap JK, Crabbe JC, Buck KJ. Potential pleiotropic effects of Mpdz on vulnerability to seizures. Genes, Brain, and Behavior. 3: 8-19. PMID 14960011 DOI: 10.1111/J.1601-183X.2004.00035.X  1
2004 Crabbe JC, Cotnam CJ, Cameron AJ, Schlumbohm JP, Rhodes JS, Metten P, Wahlsten D. Erratum: Strain differences in three measures of ethanol intoxication in mice: The screen, dowel and grip strength tests (Genes, Brain and Behavior 2 (201-213)) Genes, Brain and Behavior. 3. DOI: 10.1111/J.1601-1848.2004.00084.X  1
2003 Crabbe JC, Cotnam CJ, Cameron AJ, Schlumbohm JP, Rhodes JS, Metten P, Wahlsten D. Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes, Brain, and Behavior. 2: 201-13. PMID 12953786 DOI: 10.1034/J.1601-183X.2003.00023.X  1
2003 Bergeson SE, Kyle Warren R, Crabbe JC, Metten P, Gene Erwin V, Belknap JK. Chromosomal loci influencing chronic alcohol withdrawal severity. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 14: 454-63. PMID 12925894 DOI: 10.1007/S00335-002-2254-4  1
2003 Wahlsten D, Metten P, Crabbe JC. A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes, Brain, and Behavior. 2: 71-9. PMID 12884964 DOI: 10.1034/J.1601-183X.2003.00012.X  1
2003 Crabbe JC, Metten P, Yu CH, Schlumbohm JP, Cameron AJ, Wahlsten D. Genotypic differences in ethanol sensitivity in two tests of motor incoordination. Journal of Applied Physiology (Bethesda, Md. : 1985). 95: 1338-51. PMID 12704090 DOI: 10.1152/Japplphysiol.00132.2003  1
2003 Wahlsten D, Metten P, Crabbe JC. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Research. 971: 47-54. PMID 12691836 DOI: 10.1016/S0006-8993(03)02354-0  1
2003 Wahlsten D, Rustay NR, Metten P, Crabbe JC. In search of a better mouse test. Trends in Neurosciences. 26: 132-6. PMID 12591215 DOI: 10.1016/S0166-2236(03)00033-X  1
2003 Wahlsten D, Metten P, Phillips TJ, Boehm SL, Burkhart-Kasch S, Dorow J, Doerksen S, Downing C, Fogarty J, Rodd-Henricks K, Hen R, McKinnon CS, Merrill CM, Nolte C, Schalomon M, et al. Different data from different labs: lessons from studies of gene-environment interaction. Journal of Neurobiology. 54: 283-311. PMID 12486710 DOI: 10.1002/Neu.10173  1
2002 Crabbe JC, Metten P, Gallaher EJ, Belknap JK. Genetic determinants of sensitivity to pentobarbital in inbred mice. Psychopharmacology. 161: 408-16. PMID 12073169 DOI: 10.1007/S00213-002-1042-1  1
2002 Grisel JE, Metten P, Wenger CD, Merrill CM, Crabbe JC. Mapping of quantitative trait loci underlying ethanol metabolism in BXD recombinant inbred mouse strains. Alcoholism, Clinical and Experimental Research. 26: 610-6. PMID 12045468 DOI: 10.1111/J.1530-0277.2002.Tb02582.X  1
2002 Buck KJ, Rademacher BS, Metten P, Crabbe JC. Mapping murine loci for physical dependence on ethanol. Psychopharmacology. 160: 398-407. PMID 11919667 DOI: 10.1007/S00213-001-0988-8  1
2000 McMahon T, Andersen R, Metten P, Crabbe JC, Messing RO. Protein kinase C epsilon mediates up-regulation of N-type calcium channels by ethanol. Molecular Pharmacology. 57: 53-8. PMID 10617678  1
1999 Metten P, Crabbe JC. Genetic determinants of severity of acute withdrawal from diazepam in mice: commonality with ethanol and pentobarbital. Pharmacology, Biochemistry, and Behavior. 63: 473-9. PMID 10418790 DOI: 10.1016/S0091-3057(99)00017-9  1
1999 Buck K, Metten P, Belknap J, Crabbe J. Quantitative trait loci affecting risk for pentobarbital withdrawal map near alcohol withdrawal loci on mouse chromosomes 1, 4, and 11. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 10: 431-7. PMID 10337613 DOI: 10.1007/S003359901018  1
1998 Metten P, Phillips TJ, Crabbe JC, Tarantino LM, McClearn GE, Plomin R, Erwin VG, Belknap JK. High genetic susceptibility to ethanol withdrawal predicts low ethanol consumption. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 9: 983-90. PMID 9880664 DOI: 10.1007/S003359900911  1
1998 Metten P, Belknap JK, Crabbe JC. Drug withdrawal convulsions and susceptibility to convulsants after short-term selective breeding for acute ethanol withdrawal. Behavioural Brain Research. 95: 113-22. PMID 9754883 DOI: 10.1016/S0166-4328(97)00216-7  1
1998 Crabbe JC, Belknap JK, Metten P, Grisel JE, Buck KJ. Quantitative trait loci: mapping drug and alcohol-related genes. Advances in Pharmacology (San Diego, Calif.). 42: 1033-7. PMID 9328074 DOI: 10.1016/S1054-3589(08)60923-0  1
1997 Buck KJ, Metten P, Belknap JK, Crabbe JC. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 3946-55. PMID 9133412 DOI: 10.1523/Jneurosci.17-10-03946.1997  1
1996 Crabbe JC, Buck KJ, Metten P, Belknap JK. Strategies for identifying genes underlying drug abuse susceptibility. Nida Research Monograph. 161: 201-19. PMID 8784852  1
1994 Metten P, Crabbe JC. Common genetic determinants of severity of acute withdrawal from ethanol, pentobarbital and diazepam in inbred mice. Behavioural Pharmacology. 5: 533-547. PMID 11224305 DOI: 10.1097/00008877-199408000-00014  1
1994 Crabbe JC, Belknap JK, Buck KJ, Metten P. Use of recombinant inbred strains for studying genetic determinants of responses to alcohol. Alcohol and Alcoholism (Oxford, Oxfordshire). Supplement. 2: 67-71. PMID 8974318  1
1994 Phillips TJ, Crabbe JC, Metten P, Belknap JK. Localization of genes affecting alcohol drinking in mice. Alcoholism, Clinical and Experimental Research. 18: 931-41. PMID 7978106 DOI: 10.1111/J.1530-0277.1994.Tb00062.X  1
1993 Belknap JK, Metten P, Helms ML, O'Toole LA, Angeli-Gade S, Crabbe JC, Phillips TJ. Quantitative trait loci (QTL) applications to substances of abuse: physical dependence studies with nitrous oxide and ethanol in BXD mice. Behavior Genetics. 23: 213-22. PMID 8512534 DOI: 10.1007/Bf01067426  1
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