Nibaldo Inestrosa, Ph.D. - Publications

Affiliations: 
Departamento de Biología Celular y Molecular Pontificia Universidad Catolica de Chile, Santiago, Región Metropolitana, Chile 

256 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Pardo E, Barake F, Godoy JA, Oyanadel C, Espinoza S, Metz C, Retamal C, Massardo L, Tapia-Rojas C, Inestrosa NC, Soza A, González A. GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies. Molecular Neurobiology. PMID 31119556 DOI: 10.1007/s12035-019-1621-3  0.6
2019 Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, ... ... Inestrosa NC, et al. Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nature Cell Biology. PMID 31110288 DOI: 10.1038/s41556-019-0329-y  0.6
2019 Torres VI, Godoy JA, Inestrosa NC. Modulating Wnt signaling at the root: Porcupine and Wnt acylation. Pharmacology & Therapeutics. PMID 30790642 DOI: 10.1016/j.pharmthera.2019.02.009  0.44
2018 Cisternas P, Zolezzi JM, Lindsay C, Rivera DS, Martinez A, Bozinovic F, Inestrosa NC. New Insights into the Spontaneous Human Alzheimer's Disease-Like Model Octodon degus: Unraveling Amyloid-β Peptide Aggregation and Age-Related Amyloid Pathology. Journal of Alzheimer's Disease : Jad. PMID 30412496 DOI: 10.3233/JAD-180729  0.44
2018 Lira M, Arancibia D, Orrego PR, Montenegro-Venegas C, Cruz Y, García J, Leal-Ortiz S, Godoy JA, Gundelfinger ED, Inestrosa NC, Garner CC, Zamorano P, Torres VI. The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons. Molecular Neurobiology. PMID 30374940 DOI: 10.1007/s12035-018-1378-0  0.44
2018 Cisternas P, Zolezzi JM, Martinez M, Torres VI, Wong GW, Inestrosa NC. Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease. Journal of Neurochemistry. PMID 30300917 DOI: 10.1111/jnc.14608  0.44
2018 Tapia-Rojas C, Inestrosa NC. Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease. Neural Regeneration Research. 13: 1705-1710. PMID 30136680 DOI: 10.4103/1673-5374.238606  0.6
2018 Carreño D, Corro N, Torres-Estay V, Véliz LP, Jaimovich R, Cisternas P, San Francisco IF, Sotomayor PC, Tanasova M, Inestrosa NC, Godoy AS. Fructose and prostate cancer: toward an integrated view of cancer cell metabolism. Prostate Cancer and Prostatic Diseases. PMID 30104655 DOI: 10.1038/s41391-018-0072-7  0.44
2018 Cisternas P, Martinez M, Ahima RS, William Wong G, Inestrosa NC. Modulation of Glucose Metabolism in Hippocampal Neurons by Adiponectin and Resistin. Molecular Neurobiology. PMID 30076527 DOI: 10.1007/s12035-018-1271-x  0.44
2018 Salazar P, Cisternas P, Martinez M, Inestrosa NC. Hypothyroidism and Cognitive Disorders during Development and Adulthood: Implications in the Central Nervous System. Molecular Neurobiology. PMID 30073507 DOI: 10.1007/s12035-018-1270-y  0.44
2018 Ramos-Fernández E, Tapia-Rojas C, Ramírez VT, Inestrosa NC. Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling. Molecular Neurobiology. PMID 29967987 DOI: 10.1007/s12035-018-1162-1  0.6
2018 Zolezzi JM, Lindsay CB, Serrano FG, Ureta RC, Theoduloz C, Schmeda-Hirschmann G, Inestrosa NC. Neuroprotective Effects of Ferruginol, Jatrophone, and Junicedric Acid Against Amyloid-β Injury in Hippocampal Neurons. Journal of Alzheimer's Disease : Jad. PMID 29660932 DOI: 10.3233/JAD-170701  0.6
2018 Rivera DS, Lindsay CB, Codocedo JF, Carreño LE, Cabrera D, Arrese MA, Vio CP, Bozinovic F, Inestrosa NC. Long-Term, Fructose-Induced Metabolic Syndrome-Like Condition Is Associated with Higher Metabolism, Reduced Synaptic Plasticity and Cognitive Impairment in Octodon degus. Molecular Neurobiology. PMID 29654490 DOI: 10.1007/s12035-018-0969-0  0.36
2018 Ríos JA, Godoy JA, Inestrosa NC. Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis. Cell Communication and Signaling : Ccs. 16: 15. PMID 29642895 DOI: 10.1186/s12964-018-0227-0  0.44
2018 Godoy JA, Valdivieso AG, Inestrosa NC. Nicotine Modulates Mitochondrial Dynamics in Hippocampal Neurons. Molecular Neurobiology. PMID 29619740 DOI: 10.1007/s12035-018-1034-8  0.44
2017 Salech F, Varela-Nallar L, Arredondo SB, Bustamante DB, Andaur GA, Cisneros R, Ponce DP, Ayala P, Inestrosa NC, Valdés JL, Behrens MI, Couve A. Local Klotho enhances neuronal progenitor proliferation in the adult hippocampus. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 29300914 DOI: 10.1093/gerona/glx248  0.56
2017 Tapia-Rojas C, Inestrosa NC. Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20-APP transgenic and wild-type mice. Journal of Neurochemistry. PMID 29240990 DOI: 10.1111/jnc.14278  0.6
2017 Bustos FJ, Ampuero E, Jury N, Aguilar R, Falahi F, Toledo J, Ahumada J, Lata J, Cubillos P, Henríquez B, Guerra MV, Stehberg J, Neve RL, Inestrosa NC, Wyneken U, et al. Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice. Brain : a Journal of Neurology. PMID 29155979 DOI: 10.1093/brain/awx272  0.56
2017 Godoy JA, Zolezzi JM, Inestrosa NC. INT131 increases dendritic arborization and protects against Aβ toxicity by inducing mitochondrial changes in hippocampal neurons. Biochemical and Biophysical Research Communications. PMID 28655613 DOI: 10.1016/j.bbrc.2017.06.146  0.44
2017 Cisternas P, Inestrosa NC. Brain glucose metabolism: role of Wnt signaling in the metabolic impairment in Alzheimer's disease. Neuroscience and Biobehavioral Reviews. PMID 28624434 DOI: 10.1016/j.neubiorev.2017.06.004  0.44
2017 Zolezzi JM, Santos MJ, Bastías-Candia S, Pinto C, Godoy JA, Inestrosa NC. PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation. Biological Reviews of the Cambridge Philosophical Society. PMID 28220655 DOI: 10.1111/brv.12320  0.44
2017 Salazar P, Cisternas P, Codocedo JF, Inestrosa NC. Induction of hypothyroidism during early postnatal stages triggers a decrease in cognitive performance by decreasing hippocampal synaptic plasticity. Biochimica Et Biophysica Acta. PMID 28088629 DOI: 10.1016/j.bbadis.2017.01.002  0.44
2017 Arrázola MS, Ramos-Fernández E, Cisternas P, Ordenes D, Inestrosa NC. Wnt Signaling Prevents the Aβ Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons. Plos One. 12: e0168840. PMID 28060833 DOI: 10.1371/journal.pone.0168840  0.6
2016 Guivernau B, Bonet J, Valls-Comamala V, Bosch-Morató M, Godoy JA, Inestrosa NC, Perálvarez-Marín A, Fernández-Busquets X, Andreu D, Oliva B, Muñoz FJ. Amyloid-β Peptide Nitrotyrosination Stabilizes Oligomers and Enhances NMDAR-Mediated Toxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 11693-11703. PMID 27852777 DOI: 10.1523/JNEUROSCI.1081-16.2016  0.44
2016 Cuevas CA, Tapia-Rojas C, Cespedes C, Inestrosa NC, Vio CP. Corrigendum to "β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats". Biomed Research International. 2016: 9672429. PMID 27803932 DOI: 10.1155/2016/9672429  0.6
2016 Godoy JA, Lindsay CB, Quintanilla RA, Carvajal FJ, Cerpa W, Inestrosa NC. Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and Aβ Aggregates in Hippocampal Neurons: the Role of Mitochondria. Molecular Neurobiology. PMID 27796749 DOI: 10.1007/s12035-016-0203-x  1
2016 Tapia-Rojas C, Burgos PV, Inestrosa NC. Inhibition of Wnt signaling induces amyloidogenic processing of APP and the production and aggregation of Aβ42 peptides. Journal of Neurochemistry. PMID 27778356 DOI: 10.1111/jnc.13873  0.6
2016 Cisternas P, Salazar P, Silva-Alvarez C, Barros LF, Inestrosa NC. Activation of Wnt signaling in cortical neurons enhances glucose utilization through glycolysis. The Journal of Biological Chemistry. PMID 27703002 DOI: 10.1074/jbc.M116.735373  0.44
2016 Cisternas P, Salazar P, Silva-Álvarez C, Barros LF, Inestrosa NC. Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons. Neural Plasticity. 2016: 9839348. PMID 27688915 DOI: 10.1155/2016/9839348  0.44
2016 Estrada LD, Chamorro D, Yañez MJ, Gonzalez M, Leal N, von Bernhardi R, Dulcey AE, Marugan J, Ferrer M, Soto C, Zanlungo S, Inestrosa NC, Alvarez AR. Reduction of Blood Amyloid-β Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition. Journal of Alzheimer's Disease : Jad. PMID 27567806 DOI: 10.3233/JAD-151087  0.48
2016 Ramos-Fernández E, Tajes M, Ill-Raga G, Vargas L, Busquets-García A, Bosch-Morató M, Guivernau B, Valls-Comamala V, Gomis M, Grau C, Fandos C, Rosen MD, Rabinowitz MH, Inestrosa N, Maldonado R, et al. Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons. Oncotarget. PMID 27557499 DOI: 10.18632/oncotarget.11417  1
2016 Rivera DS, Lindsay C, Codocedo JF, Morel I, Pinto C, Cisternas P, Bozinovic F, Inestrosa NC. Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus). Neurobiology of Aging. 46: 204-220. PMID 27505720 DOI: 10.1016/j.neurobiolaging.2016.06.021  1
2016 Ramírez VT, Ramos-Fernández E, Henríquez JP, Lorenzo A, Inestrosa NC. Wnt-5a/Frizzled9 receptor signaling through the Gαo/Gβγ complex regulates dendritic spine formation. The Journal of Biological Chemistry. PMID 27402827 DOI: 10.1074/jbc.M116.722132  0.6
2016 Mardones MD, Andaur GA, Varas-Godoy M, Henriquez JF, Salech F, Behrens MI, Couve A, Inestrosa NC, Varela-Nallar L. Frizzled-1 receptor regulates adult hippocampal neurogenesis. Molecular Brain. 9: 29. PMID 26980182 DOI: 10.1186/s13041-016-0209-3  0.56
2016 Rivera DS, Inestrosa NC, Bozinovic F. On cognitive ecology and the environmental factors that promote Alzheimer disease: lessons from Octodon degus (Rodentia: Octodontidae). Biological Research. 49: 10. PMID 26897365 DOI: 10.1186/s40659-016-0074-7  1
2016 Codocedo JF, Inestrosa NC. Wnt-5a-regulated miR-101b controls COX2 expression in hippocampal neurons. Biological Research. 49: 9. PMID 26895946 DOI: 10.1186/s40659-016-0071-x  1
2016 Vallejo D, Codocedo JF, Inestrosa NC. Posttranslational Modifications Regulate the Postsynaptic Localization of PSD-95. Molecular Neurobiology. PMID 26884267 DOI: 10.1007/s12035-016-9745-1  1
2016 Ramírez VT, Ramos-Fernández E, Inestrosa NC. The Gα o Activator Mastoparan-7 Promotes Dendritic Spine Formation in Hippocampal Neurons. Neural Plasticity. 2016: 4258171. PMID 26881110 DOI: 10.1155/2016/4258171  1
2016 Martínez G, Vidal RL, Mardones P, Serrano FG, Ardiles AO, Wirth C, Valdés P, Thielen P, Schneider BL, Kerr B, Valdés JL, Palacios AG, Inestrosa NC, Glimcher LH, Hetz C. Regulation of Memory Formation by the Transcription Factor XBP1. Cell Reports. PMID 26854229 DOI: 10.1016/j.celrep.2016.01.028  1
2015 Varela-Nallar L, Arredondo SB, Tapia-Rojas C, Hancke J, Inestrosa NC. Andrographolide Stimulates Neurogenesis in the Adult Hippocampus. Neural Plasticity. 2015: 935403. PMID 26798521 DOI: 10.1155/2015/935403  1
2015 Fuenzalida M, Espinoza C, Pérez MÁ, Tapia-Rojas C, Cuitino L, Brandan E, Inestrosa NC. Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy. Neurobiology of Disease. PMID 26626079 DOI: 10.1016/j.nbd.2015.11.018  1
2015 Codocedo JF, Inestrosa NC. Environmental control of microRNAs in the nervous system: Implications in plasticity and behavior. Neuroscience and Biobehavioral Reviews. PMID 26593111 DOI: 10.1016/j.neubiorev.2015.10.010  1
2015 Tapia-Rojas C, Lindsay CB, Montecinos-Oliva C, Arrazola MS, Retamales RM, Bunout D, Hirsch S, Inestrosa NC. Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice. Molecular Neurodegeneration. 10: 62. PMID 26590557 DOI: 10.1186/s13024-015-0057-0  1
2015 Serrano FG, Tapia-Rojas C, Carvajal FJ, Cisternas P, Viayna E, Irene S, Muñoz-Torrero D, Inestrosa NC. Rhein-huprine derivatives reduce cognitive impairment, synaptic failure and amyloid pathology in AβPPswe/PS-1 mice of different ages. Current Alzheimer Research. PMID 26502813  0.6
2015 Cisternas P, Lindsay CB, Salazar P, Silva-Alvarez C, Retamales RM, Serrano FG, Vio CP, Inestrosa NC. The increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer's disease. Biochimica Et Biophysica Acta. 1852: 2630-44. PMID 26391254 DOI: 10.1016/j.bbadis.2015.09.009  1
2015 Dinamarca MC, Di Luca M, Godoy JA, Inestrosa NC. The soluble extracellular fragment of neuroligin-1 targets Aβ oligomers to the postsynaptic region of excitatory synapses. Biochemical and Biophysical Research Communications. 466: 66-71. PMID 26325471 DOI: 10.1016/j.bbrc.2015.08.107  1
2015 Parodi J, Montecinos-Oliva C, Varas R, Alfaro IE, Serrano FG, Varas-Godoy M, Muñoz FJ, Cerpa W, Godoy JA, Inestrosa NC. Wnt5a inhibits K(+) currents in hippocampal synapses through nitric oxide production. Molecular and Cellular Neurosciences. 68: 314-22. PMID 26311509 DOI: 10.1016/j.mcn.2015.08.011  1
2015 Cavieres VA, González A, Muñoz VC, Yefi CP, Bustamante HA, Barraza RR, Tapia-Rojas C, Otth C, Barrera MJ, González C, Mardones GA, Inestrosa NC, Burgos PV. Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy. Plos One. 10: e0136313. PMID 26308941 DOI: 10.1371/journal.pone.0136313  1
2015 Cisternas P, Salazar P, Serrano FG, Montecinos-Oliva C, Arredondo SB, Varela-Nallar L, Barja S, Vio CP, Gomez-Pinilla F, Inestrosa NC. Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance. Biochimica Et Biophysica Acta. 1852: 2379-90. PMID 26300486 DOI: 10.1016/j.bbadis.2015.08.016  0.6
2015 Du LY, Chang LY, Ardiles AO, Tapia-Rojas C, Araya J, Inestrosa NC, Palacios AG, Acosta ML. Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus. Plos One. 10: e0135499. PMID 26267479 DOI: 10.1371/journal.pone.0135499  0.6
2015 Montecinos-Oliva C, Schüller A, Inestrosa NC. Tetrahydrohyperforin: a neuroprotective modified natural compound against Alzheimer's disease. Neural Regeneration Research. 10: 552-4. PMID 26170810 DOI: 10.4103/1673-5374.155420  1
2015 Codocedo JF, Montecinos-Oliva C, Inestrosa NC. Wnt-related SynGAP1 is a neuroprotective factor of glutamatergic synapses against Aβ oligomers. Frontiers in Cellular Neuroscience. 9: 227. PMID 26124704 DOI: 10.3389/fncel.2015.00227  1
2015 Alfaro IE, Varela-Nallar L, Varas-Godoy M, Inestrosa NC. The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons. Molecular and Cellular Neurosciences. 67: 22-30. PMID 26003414 DOI: 10.1016/j.mcn.2015.05.002  1
2015 Arrázola MS, Silva-Alvarez C, Inestrosa NC. How the Wnt signaling pathway protects from neurodegeneration: the mitochondrial scenario. Frontiers in Cellular Neuroscience. 9: 166. PMID 25999816 DOI: 10.3389/fncel.2015.00166  1
2015 Codocedo JF, Ríos JA, Godoy JA, Inestrosa NC. Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer's Disease? Molecular Neurobiology. PMID 25976367 DOI: 10.1007/s12035-015-9201-7  1
2015 Lambert C, Cisternas P, Inestrosa NC. Role of Wnt Signaling in Central Nervous System Injury. Molecular Neurobiology. PMID 25976365 DOI: 10.1007/s12035-015-9138-x  0.44
2015 Cuevas CA, Tapia-Rojas C, Cespedes C, Inestrosa NC, Vio CP. β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats. Biomed Research International. 2015: 726012. PMID 25945342 DOI: 10.1155/2015/726012  1
2015 Oliva CA, Inestrosa NC. A novel function for Wnt signaling modulating neuronal firing activity and the temporal structure of spontaneous oscillation in the entorhinal-hippocampal circuit. Experimental Neurology. 269: 43-55. PMID 25857536 DOI: 10.1016/j.expneurol.2015.03.027  1
2015 Tapia-Rojas C, Aranguiz F, Varela-Nallar L, Inestrosa NC. Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease. Brain Pathology (Zurich, Switzerland). PMID 25763997 DOI: 10.1111/bpa.12255  1
2015 Segovia-Miranda F, Serrano F, Dyrda A, Ampuero E, Retamal C, Bravo-Zehnder M, Parodi J, Zamorano P, Valenzuela D, Massardo L, van Zundert B, Inestrosa NC, González A. Pathogenicity of lupus anti-ribosomal p antibodies: role of cross-reacting neuronal surface p antigen in glutamatergic transmission and plasticity in a mouse model. Arthritis & Rheumatology (Hoboken, N.J.). 67: 1598-610. PMID 25709106 DOI: 10.1002/art.39081  1
2015 Bastías-Candia S, Braidy N, Zolezzi JM, Inestrosa NC. Teneurins and Alzheimer's disease: a suggestive role for a unique family of proteins. Medical Hypotheses. 84: 402-7. PMID 25665860 DOI: 10.1016/j.mehy.2015.01.026  1
2015 Retamales-Ortega R, Vio CP, Inestrosa NC. P2C-Type ATPases and Their Regulation. Molecular Neurobiology. PMID 25631710 DOI: 10.1007/s12035-014-9076-z  1
2015 Braidy N, Poljak A, Jayasena T, Mansour H, Inestrosa NC, Sachdev PS. Accelerating Alzheimer's research through 'natural' animal models. Current Opinion in Psychiatry. 28: 155-64. PMID 25602247 DOI: 10.1097/YCO.0000000000000137  1
2015 Vargas JY, Ahumada J, Arrázola MS, Fuenzalida M, Inestrosa NC. WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by Aβ oligomers. Experimental Neurology. 264: 14-25. PMID 25450465 DOI: 10.1016/j.expneurol.2014.11.005  1
2015 Arrázola MS, Inestrosa NC. Monitoring mitochondrial membranes permeability in live neurons and mitochondrial swelling through electron microscopy analysis. Methods in Molecular Biology (Clifton, N.J.). 1254: 87-97. PMID 25431059 DOI: 10.1007/978-1-4939-2152-2_7  1
2015 Tapia-Rojas C, Schüller A, Lindsay CB, Ureta RC, Mejías-Reyes C, Hancke J, Melo F, Inestrosa NC. Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: autoregulation of GSK-3β in vivo. The Biochemical Journal. 466: 415-30. PMID 25423492 DOI: 10.1042/BJ20140207  1
2015 Cuevas CA, Gonzalez AA, Inestrosa NC, Vio CP, Prieto MC. Angiotensin II increases fibronectin and collagen I through the β-catenin-dependent signaling in mouse collecting duct cells. American Journal of Physiology. Renal Physiology. 308: F358-65. PMID 25411386 DOI: 10.1152/ajprenal.00429.2014  1
2015 Bravo-Zehnder M, Toledo EM, Segovia-Miranda F, Serrano FG, Benito MJ, Metz C, Retamal C, Álvarez A, Massardo L, Inestrosa NC, González A. Anti-ribosomal P protein autoantibodies from patients with neuropsychiatric lupus impair memory in mice. Arthritis & Rheumatology (Hoboken, N.J.). 67: 204-14. PMID 25302407 DOI: 10.1002/art.38900  1
2015 Inestrosa NC, Varela-Nallar L. Wnt signalling in neuronal differentiation and development. Cell and Tissue Research. 359: 215-23. PMID 25234280 DOI: 10.1007/s00441-014-1996-4  1
2015 Minniti AN, Arrazola MS, Bravo-Zehnder M, Ramos F, Inestrosa NC, Aldunate R. The protein oxidation repair enzyme methionine sulfoxide reductase a modulates Aβ aggregation and toxicity in vivo. Antioxidants & Redox Signaling. 22: 48-62. PMID 24988428 DOI: 10.1089/ars.2013.5803  1
2015 Du LY, Chang LYL, Ardiles A, Tapia-Rojas C, Araya J, Inestrosa NC, Palacios AG, Acosta ML. Alzheimer's disease-related protein expression in the retina of Octodon degus Plos One. 10. DOI: 10.1371/journal.pone.0135499  1
2015 Parodi J, Montecinos-Oliva C, Varas R, Alfaro IE, Serrano FG, Varas-Godoy M, Muñoz FJ, Cerpa W, Godoy JA, Inestrosa NC. Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production Molecular and Cellular Neuroscience. 68: 314-322. DOI: 10.1016/j.mcn.2015.08.011  1
2015 Cisternas P, Salazar P, Serrano FG, Montecinos-Oliva C, Arredondo SB, Varela-Nallar L, Barja S, Vio CP, Gomez-Pinilla F, Inestrosa NC. Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance Biochimica Et Biophysica Acta - Molecular Basis of Disease. 1852: 2379-2390. DOI: 10.1016/j.bbadis.2015.08.016  1
2015 Lambert C, Cisternas P, Inestrosa NC. Role of Wnt Signaling in Central Nervous System Injury Molecular Neurobiology. DOI: 10.1007/s12035-015-9138-x  1
2015 Montecinos-Oliva C, Tapia-Rojas C, Burgos PV, Inestrosa NC. New discoveries on the hyperforin derivative, tetrahydrohyperforin: Closer to an Alzheimer'S disease treatment? Hypericum: Botanical Sources, Medical Properties and Health Effects. 119-137.  1
2014 Serrano FG, Tapia-Rojas C, Carvajal FJ, Hancke J, Cerpa W, Inestrosa NC. Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice. Molecular Neurodegeneration. 9: 61. PMID 25524173 DOI: 10.1186/1750-1326-9-61  1
2014 Cerpa W, Ramos-Fernández E, Inestrosa NC. Modulation of the NMDA Receptor Through Secreted Soluble Factors. Molecular Neurobiology. PMID 25429903 DOI: 10.1007/s12035-014-9009-x  1
2014 Inestrosa NC, Ríos JA, Cisternas P, Tapia-Rojas C, Rivera DS, Braidy N, Zolezzi JM, Godoy JA, Carvajal FJ, Ardiles AO, Bozinovic F, Palacios AG, Sachdev PS. Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease. Brain Pathology (Zurich, Switzerland). PMID 25351914 DOI: 10.1111/bpa.12226  1
2014 Godoy JA, Arrázola MS, Ordenes D, Silva-Alvarez C, Braidy N, Inestrosa NC. Wnt-5a ligand modulates mitochondrial fission-fusion in rat hippocampal neurons. The Journal of Biological Chemistry. 289: 36179-93. PMID 25336659 DOI: 10.1074/jbc.M114.557009  1
2014 Quintanilla RA, von Bernhardi R, Godoy JA, Inestrosa NC, Johnson GV. Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons. Neurobiology of Disease. 71: 260-9. PMID 25134729 DOI: 10.1016/j.nbd.2014.08.016  1
2014 Zolezzi JM, Bastías-Candia S, Santos MJ, Inestrosa NC. Alzheimer's disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs. Frontiers in Aging Neuroscience. 6: 176. PMID 25120477 DOI: 10.3389/fnagi.2014.00176  1
2014 Ríos JA, Cisternas P, Arrese M, Barja S, Inestrosa NC. Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum. Progress in Neurobiology. 121: 125-46. PMID 25084549 DOI: 10.1016/j.pneurobio.2014.07.004  1
2014 Braidy N, Poljak A, Marjo C, Rutlidge H, Rich A, Jayasena T, Inestrosa NC, Sachdev P. Metal and complementary molecular bioimaging in Alzheimer's disease. Frontiers in Aging Neuroscience. 6: 138. PMID 25076902 DOI: 10.3389/fnagi.2014.00138  1
2014 Montecinos-Oliva C, Schuller A, Parodi J, Melo F, Inestrosa NC. Effects of tetrahydrohyperforin in mouse hippocampal slices: neuroprotection, long-term potentiation and TRPC channels. Current Medicinal Chemistry. 21: 3494-506. PMID 25039785  1
2014 Braidy N, Brew BJ, Inestrosa NC, Chung R, Sachdev P, Guillemin GJ. Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons. Metabolic Brain Disease. 29: 873-83. PMID 24833554 DOI: 10.1007/s11011-014-9557-9  1
2014 Cisternas P, Vio CP, Inestrosa NC. Role of Wnt signaling in tissue fibrosis, lessons from skeletal muscle and kidney. Current Molecular Medicine. 14: 510-22. PMID 24730522 DOI: 10.2174/1566524014666140414210346  1
2014 Bustos FJ, Varela-Nallar L, Campos M, Henriquez B, Phillips M, Opazo C, Aguayo LG, Montecino M, Constantine-Paton M, Inestrosa NC, van Zundert B. PSD95 suppresses dendritic arbor development in mature hippocampal neurons by occluding the clustering of NR2B-NMDA receptors. Plos One. 9: e94037. PMID 24705401 DOI: 10.1371/journal.pone.0094037  1
2014 Godoy JA, Rios JA, Zolezzi JM, Braidy N, Inestrosa NC. Signaling pathway cross talk in Alzheimer's disease. Cell Communication and Signaling : Ccs. 12: 23. PMID 24679124 DOI: 10.1186/1478-811X-12-23  1
2014 Zolezzi JM, Inestrosa NC. Brain metabolite clearance: impact on Alzheimer's disease. Metabolic Brain Disease. 29: 553-61. PMID 24664180 DOI: 10.1007/s11011-014-9527-2  1
2014 Vargas LM, Leal N, Estrada LD, González A, Serrano F, Araya K, Gysling K, Inestrosa NC, Pasquale EB, Alvarez AR. EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. Plos One. 9: e92309. PMID 24658113 DOI: 10.1371/journal.pone.0092309  1
2014 Varela-Nallar L, Rojas-Abalos M, Abbott AC, Moya EA, Iturriaga R, Inestrosa NC. Chronic hypoxia induces the activation of the Wnt/β-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1ΔE9 transgenic mice in vivo. Frontiers in Cellular Neuroscience. 8: 17. PMID 24574965 DOI: 10.3389/fncel.2014.00017  1
2014 Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabaté R, Juárez-Jiménez J, Pérez B, Luque FJ, Andrisano V, Clos MV, Inestrosa NC, Muñoz-Torrero D. Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents. Journal of Medicinal Chemistry. 57: 2549-67. PMID 24568372 DOI: 10.1021/jm401824w  1
2014 Inestrosa NC, Varela-Nallar L. Wnt signaling in the nervous system and in Alzheimer's disease. Journal of Molecular Cell Biology. 6: 64-74. PMID 24549157 DOI: 10.1093/jmcb/mjt051  1
2014 Vargas JY, Fuenzalida M, Inestrosa NC. In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 2191-202. PMID 24501359 DOI: 10.1523/JNEUROSCI.0862-13.2014  1
2014 Godoy JA, Zolezzi JM, Braidy N, Inestrosa NC. Role of Sirt1 during the ageing process: relevance to protection of synapses in the brain. Molecular Neurobiology. 50: 744-56. PMID 24496572 DOI: 10.1007/s12035-014-8645-5  1
2014 Muñoz FJ, Godoy JA, Cerpa W, Poblete IM, Huidobro-Toro JP, Inestrosa NC. Wnt-5a increases NO and modulates NMDA receptor in rat hippocampal neurons. Biochemical and Biophysical Research Communications. 444: 189-94. PMID 24440698 DOI: 10.1016/j.bbrc.2014.01.031  1
2014 Cisternas P, Henriquez JP, Brandan E, Inestrosa NC. Wnt signaling in skeletal muscle dynamics: myogenesis, neuromuscular synapse and fibrosis. Molecular Neurobiology. 49: 574-89. PMID 24014138 DOI: 10.1007/s12035-013-8540-5  1
2013 Oliva CA, Vargas JY, Inestrosa NC. Wnts in adult brain: from synaptic plasticity to cognitive deficiencies. Frontiers in Cellular Neuroscience. 7: 224. PMID 24348327 DOI: 10.3389/fncel.2013.00224  1
2013 Slater PG, Ramirez VT, Gonzalez-Billault C, Varela-Nallar L, Inestrosa NC. Frizzled-5 receptor is involved in neuronal polarity and morphogenesis of hippocampal neurons. Plos One. 8: e78892. PMID 24205342 DOI: 10.1371/journal.pone.0078892  1
2013 Zolezzi JM, Carvajal FJ, Ríos JA, Ordenes D, Silva-Alvarez C, Godoy JA, Inestrosa NC. Tetrahydrohyperforin induces mitochondrial dynamics and prevents mitochondrial Ca2+ overload after Aβ and Aβ-AChE complex challenge in rat hippocampal neurons. Journal of Alzheimer's Disease : Jad. 37: 735-46. PMID 23948911 DOI: 10.3233/JAD-130173  1
2013 Rosso SB, Inestrosa NC. WNT signaling in neuronal maturation and synaptogenesis. Frontiers in Cellular Neuroscience. 7: 103. PMID 23847469 DOI: 10.3389/fncel.2013.00103  1
2013 Inestrosa NC, Godoy JA, Vargas JY, Arrazola MS, Rios JA, Carvajal FJ, Serrano FG, Farias GG. Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation. Neuromolecular Medicine. 15: 549-69. PMID 23842742 DOI: 10.1007/s12017-013-8242-1  1
2013 Varela-Nallar L, Inestrosa NC. Wnt signaling in the regulation of adult hippocampal neurogenesis. Frontiers in Cellular Neuroscience. 7: 100. PMID 23805076 DOI: 10.3389/fncel.2013.00100  1
2013 Silva-Alvarez C, Arrázola MS, Godoy JA, Ordenes D, Inestrosa NC. Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics. Frontiers in Cellular Neuroscience. 7: 97. PMID 23805073 DOI: 10.3389/fncel.2013.00097  1
2013 Quintanilla RA, Godoy JA, Alfaro I, Cabezas D, von Bernhardi R, Bronfman M, Inestrosa NC. Thiazolidinediones promote axonal growth through the activation of the JNK pathway. Plos One. 8: e65140. PMID 23741474 DOI: 10.1371/journal.pone.0065140  1
2013 Zolezzi JM, Silva-Alvarez C, Ordenes D, Godoy JA, Carvajal FJ, Santos MJ, Inestrosa NC. Peroxisome proliferator-activated receptor (PPAR) γ and PPARα agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders? Plos One. 8: e64019. PMID 23675519 DOI: 10.1371/journal.pone.0064019  1
2013 Oliva CA, Vargas JY, Inestrosa NC. Wnt signaling: role in LTP, neural networks and memory. Ageing Research Reviews. 12: 786-800. PMID 23665425 DOI: 10.1016/j.arr.2013.03.006  1
2013 Carvajal FJ, Zolezzi JM, Tapia-Rojas C, Godoy JA, Inestrosa NC. Tetrahydrohyperforin decreases cholinergic markers associated with amyloid-β plaques, 4-hydroxynonenal formation, and caspase-3 activation in AβPP/PS1 mice. Journal of Alzheimer's Disease : Jad. 36: 99-118. PMID 23568104 DOI: 10.3233/JAD-130230  1
2013 Zolezzi JM, Inestrosa NC. Peroxisome proliferator-activated receptors and Alzheimer's disease: hitting the blood-brain barrier. Molecular Neurobiology. 48: 438-51. PMID 23494748 DOI: 10.1007/s12035-013-8435-5  1
2013 Codocedo JF, Godoy JA, Poblete MI, Inestrosa NC, Huidobro-Toro JP. ATP induces NO production in hippocampal neurons by P2X(7) receptor activation independent of glutamate signaling. Plos One. 8: e57626. PMID 23472093 DOI: 10.1371/journal.pone.0057626  1
2013 Abbott AC, Calderon Toledo C, Aranguiz FC, Inestrosa NC, Varela-Nallar L. Tetrahydrohyperforin increases adult hippocampal neurogenesis in wild-type and APPswe/PS1ΔE9 mice. Journal of Alzheimer's Disease : Jad. 34: 873-85. PMID 23302657 DOI: 10.3233/JAD-121714  1
2013 Inestrosa NC, Carvajal FJ, Zolezzi JM, Tapia-Rojas C, Serrano F, Karmelic D, Toledo EM, Toro A, Toro J, Santos MJ. Peroxisome proliferators reduce spatial memory impairment, synaptic failure, and neurodegeneration in brains of a double transgenic mice model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 33: 941-59. PMID 23109558 DOI: 10.3233/JAD-2012-120397  1
2012 Dinamarca MC, Ríos JA, Inestrosa NC. Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer's Disease. Frontiers in Physiology. 3: 464. PMID 23267328 DOI: 10.3389/fphys.2012.00464  1
2012 Inestrosa NC, Montecinos-Oliva C, Fuenzalida M. Wnt signaling: role in Alzheimer disease and schizophrenia. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 7: 788-807. PMID 23160851 DOI: 10.1007/s11481-012-9417-5  1
2012 Codocedo JF, Allard C, Godoy JA, Varela-Nallar L, Inestrosa NC. SIRT1 regulates dendritic development in hippocampal neurons. Plos One. 7: e47073. PMID 23056585 DOI: 10.1371/journal.pone.0047073  1
2012 Ardiles AO, Tapia-Rojas CC, Mandal M, Alexandre F, Kirkwood A, Inestrosa NC, Palacios AG. Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 109: 13835-40. PMID 22869717 DOI: 10.1073/pnas.1201209109  1
2012 Aldunate R, Minniti AN, Rebolledo D, Inestrosa NC. Synaptic defects associated with s-inclusion body myositis are prevented by copper. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 25: 815-24. PMID 22573194 DOI: 10.1007/s10534-012-9553-7  1
2012 Cabeza C, Figueroa A, Lazo OM, Galleguillos C, Pissani C, Klein A, Gonzalez-Billault C, Inestrosa NC, Alvarez AR, Zanlungo S, Bronfman FC. Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick type C disease. Molecular Neurodegeneration. 7: 11. PMID 22458984 DOI: 10.1186/1750-1326-7-11  1
2012 Varela-Nallar L, Ramirez VT, Gonzalez-Billault C, Inestrosa NC. Frizzled receptors in neurons: from growth cones to the synapse. Cytoskeleton (Hoboken, N.J.). 69: 528-34. PMID 22407911 DOI: 10.1002/cm.21022  1
2012 Assar R, Leisewitz AV, Garcia A, Inestrosa NC, Montecino MA, Sherman DJ. Reusing and composing models of cell fate regulation of human bone precursor cells. Bio Systems. 108: 63-72. PMID 22309764 DOI: 10.1016/j.biosystems.2012.01.008  1
2012 Varela-Nallar L, Parodi J, Farías GG, Inestrosa NC. Wnt-5a is a synaptogenic factor with neuroprotective properties against Aβ toxicity. Neuro-Degenerative Diseases. 10: 23-6. PMID 22261402 DOI: 10.1159/000333360  1
2012 Braidy N, Muñoz P, Palacios AG, Castellano-Gonzalez G, Inestrosa NC, Chung RS, Sachdev P, Guillemin GJ. Recent rodent models for Alzheimer's disease: clinical implications and basic research. Journal of Neural Transmission (Vienna, Austria : 1996). 119: 173-95. PMID 22086139 DOI: 10.1007/s00702-011-0731-5  1
2011 Inestrosa NC, Tapia-Rojas C, Griffith TN, Carvajal FJ, Benito MJ, Rivera-Dictter A, Alvarez AR, Serrano FG, Hancke JL, Burgos PV, Parodi J, Varela-Nallar L. Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: a possible effect on APP processing. Translational Psychiatry. 1: e20. PMID 22832522 DOI: 10.1038/tp.2011.19  1
2011 Lorca RA, Varela-Nallar L, Inestrosa NC, Huidobro-Toro JP. The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X(4) Receptors. International Journal of Alzheimer's Disease. 2011: 706576. PMID 22114745 DOI: 10.4061/2011/706576  1
2011 Carvajal FJ, Inestrosa NC. Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Frontiers in Molecular Neuroscience. 4: 19. PMID 21949501 DOI: 10.3389/fnmol.2011.00019  0.6
2011 Dinamarca MC, Weinstein D, Monasterio O, Inestrosa NC. The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease? Biochemistry. 50: 8127-37. PMID 21838267 DOI: 10.1021/bi201246t  1
2011 Rebolledo DL, Aldunate R, Kohn R, Neira I, Minniti AN, Inestrosa NC. Copper reduces Aβ oligomeric species and ameliorates neuromuscular synaptic defects in a C. elegans model of inclusion body myositis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10149-58. PMID 21752991 DOI: 10.1523/JNEUROSCI.0336-11.2011  1
2011 Gonzalez-Billaul C, Inestrosa NC, Santos MJ. Contributions by researchers of "Ciencia de Frontera" of the Chilean Academy of Sciences. Biological Research. 44: 5. PMID 21720675  1
2011 Cerpa W, Gambrill A, Inestrosa NC, Barria A. Regulation of NMDA-receptor synaptic transmission by Wnt signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9466-71. PMID 21715611 DOI: 10.1523/JNEUROSCI.6311-10.2011  1
2011 Rosas-Arellano A, Parodi J, Machuca-Parra AI, Sánchez-Gutiérrez A, Inestrosa NC, Miledi R, Martínez-Torres A. The GABA(A)ρ receptors in hippocampal spontaneous activity and their distribution in hippocampus, amygdala and visual cortex. Neuroscience Letters. 500: 20-5. PMID 21683123 DOI: 10.1016/j.neulet.2011.05.235  1
2011 Mesa R, Luo S, Hoover CM, Miller K, Minniti A, Inestrosa N, Nonet ML. HID-1, a new component of the peptidergic signaling pathway. Genetics. 187: 467-83. PMID 21115972 DOI: 10.1534/genetics.110.121996  1
2010 Varela-Nallar L, Aranguiz FC, Abbott AC, Slater PG, Inestrosa NC. Adult hippocampal neurogenesis in aging and Alzheimer's disease. Birth Defects Research. Part C, Embryo Today : Reviews. 90: 284-96. PMID 21181889 DOI: 10.1002/bdrc.20193  1
2010 Varela-Nallar L, Alfaro IE, Serrano FG, Parodi J, Inestrosa NC. Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses. Proceedings of the National Academy of Sciences of the United States of America. 107: 21164-9. PMID 21084636 DOI: 10.1073/pnas.1010011107  1
2010 Reale M, Brenner T, Greig NH, Inestrosa N, Paleacu D. Neuroinflammation, AD, and Dementia. International Journal of Alzheimer's Disease. 2010. PMID 20871836 DOI: 10.4061/2010/974026  1
2010 Cuitino L, Godoy JA, Farías GG, Couve A, Bonansco C, Fuenzalida M, Inestrosa NC. Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8411-20. PMID 20573888 DOI: 10.1523/JNEUROSCI.5736-09.2010  1
2010 Hödar C, Assar R, Colombres M, Aravena A, Pavez L, González M, Martínez S, Inestrosa NC, Maass A. Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method. Bmc Genomics. 11: 348. PMID 20515496 DOI: 10.1186/1471-2164-11-348  1
2010 Perez de Arce K, de Arce KP, Varela-Nallar L, Farias O, Cifuentes A, Bull P, Couch BA, Koleske AJ, Inestrosa NC, Alvarez AR. Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3728-38. PMID 20220006 DOI: 10.1523/JNEUROSCI.2024-09.2010  1
2010 Lazo OM, Mauna JC, Pissani CA, Inestrosa NC, Bronfman FC. Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons. Molecular Neurodegeneration. 5: 5. PMID 20205865 DOI: 10.1186/1750-1326-5-5  1
2010 Dinamarca MC, Sagal JP, Quintanilla RA, Godoy JA, Arrázola MS, Inestrosa NC. Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Abeta peptide. Implications for the pathogenesis of Alzheimer's disease. Molecular Neurodegeneration. 5: 4. PMID 20205793 DOI: 10.1186/1750-1326-5-4  1
2010 Cerpa W, Farías GG, Godoy JA, Fuenzalida M, Bonansco C, Inestrosa NC. Wnt-5a occludes Abeta oligomer-induced depression of glutamatergic transmission in hippocampal neurons. Molecular Neurodegeneration. 5: 3. PMID 20205789 DOI: 10.1186/1750-1326-5-3  1
2010 Griffith TN, Varela-Nallar L, Dinamarca MC, Inestrosa NC. Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy. Current Medicinal Chemistry. 17: 391-406. PMID 20015041 DOI: 10.2174/092986710790226156  1
2010 Inestrosa NC, Arenas E. Emerging roles of Wnts in the adult nervous system. Nature Reviews. Neuroscience. 11: 77-86. PMID 20010950 DOI: 10.1038/nrn2755  1
2010 Cerpa W, Hancke JL, Morazzoni P, Bombardelli E, Riva A, Marin PP, Inestrosa NC. The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model. Current Alzheimer Research. 7: 126-33. PMID 19939230 DOI: 10.2174/156720510790691218  1
2010 Parodi J, Sepúlveda FJ, Roa J, Opazo C, Inestrosa NC, Aguayo LG. Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure. The Journal of Biological Chemistry. 285: 2506-14. PMID 19915004 DOI: 10.1074/jbc.M109.030023  1
2010 Farías GG, Godoy JA, Cerpa W, Varela-Nallar L, Inestrosa NC. Wnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 94-101. PMID 19681159 DOI: 10.1002/dvdy.22065  1
2010 Toledo EM, Inestrosa NC. Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease. Molecular Psychiatry. 15: 272-85, 228. PMID 19621015 DOI: 10.1038/mp.2009.72  1
2010 Toledo EM, Inestrosa NC. Wnt signaling activation reduces neuropathological markers in a mouse model of Alzheimer's disease Molecular Psychiatry. 15: 228. DOI: 10.1038/mp.2010.9  1
2009 Cerpa W, Toledo EM, Varela-Nallar L, Inestrosa NC. The role of Wnt signaling in neuroprotection. Drug News & Perspectives. 22: 579-91. PMID 20140278 DOI: 10.1358/dnp.2009.10.1436817  1
2009 Varela-Nallar L, Grabowski CP, Alfaro IE, Alvarez AR, Inestrosa NC. Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function. Neural Development. 4: 41. PMID 19883499 DOI: 10.1186/1749-8104-4-41  1
2009 Minniti AN, Cataldo R, Trigo C, Vasquez L, Mujica P, Leighton F, Inestrosa NC, Aldunate R. Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans. Aging Cell. 8: 690-705. PMID 19747232 DOI: 10.1111/j.1474-9726.2009.00521.x  1
2009 Arrázola MS, Varela-Nallar L, Colombres M, Toledo EM, Cruzat F, Pavez L, Assar R, Aravena A, González M, Montecino M, Maass A, Martínez S, Inestrosa NC. Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway. Journal of Cellular Physiology. 221: 658-67. PMID 19711354 DOI: 10.1002/jcp.21902  1
2009 Farías GG, Alfaro IE, Cerpa W, Grabowski CP, Godoy JA, Bonansco C, Inestrosa NC. Wnt-5a/JNK signaling promotes the clustering of PSD-95 in hippocampal neurons. The Journal of Biological Chemistry. 284: 15857-66. PMID 19332546 DOI: 10.1074/jbc.M808986200  1
2009 Suazo M, Hodar C, Morgan C, Cerpa W, Cambiazo V, Inestrosa NC, Gonzalez M. Overexpression of amyloid precursor protein increases copper content in HEK293 cells. Biochemical and Biophysical Research Communications. 382: 740-4. PMID 19318086 DOI: 10.1016/j.bbrc.2009.03.096  1
2009 Vázquez MC, Vargas LM, Inestrosa NC, Alvarez AR. c-Abl modulates AICD dependent cellular responses: transcriptional induction and apoptosis. Journal of Cellular Physiology. 220: 136-43. PMID 19306298 DOI: 10.1002/jcp.21743  1
2009 Minniti AN, Rebolledo DL, Grez PM, Fadic R, Aldunate R, Volitakis I, Cherny RA, Opazo C, Masters C, Bush AI, Inestrosa NC. Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification. Molecular Neurodegeneration. 4: 2. PMID 19126228 DOI: 10.1186/1750-1326-4-2  1
2009 Inestrosa NC, Grabowski C, Arrázola M, Varela-Nallar L, Toledo EM. Role of Alzheimer's β-Amyloid on Wnt signaling Protein Misfolding Disorders: a Trip Into the Er. 103-113. DOI: 10.2174/978160805013010901010103  1
2008 Toledo EM, Colombres M, Inestrosa NC. Wnt signaling in neuroprotection and stem cell differentiation. Progress in Neurobiology. 86: 281-96. PMID 18786602 DOI: 10.1016/j.pneurobio.2008.08.001  1
2008 Rebolledo DL, Minniti AN, Grez PM, Fadic R, Kohn R, Inestrosa NC. Inclusion body myositis: a view from the Caenorhabditis elegans muscle. Molecular Neurobiology. 38: 178-98. PMID 18773311 DOI: 10.1007/s12035-008-8041-0  1
2008 Inestrosa NC, Toledo EM. The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease. Molecular Neurodegeneration. 3: 9. PMID 18652670 DOI: 10.1186/1750-1326-3-9  1
2008 Simonetta SH, Romanowski A, Minniti AN, Inestrosa NC, Golombek DA. Circadian stress tolerance in adult Caenorhabditis elegans. Journal of Comparative Physiology. a, Neuroethology, Sensory, Neural, and Behavioral Physiology. 194: 821-8. PMID 18648821 DOI: 10.1007/s00359-008-0353-z  1
2008 Dinamarca MC, Arrázola M, Toledo E, Cerpa WF, Hancke J, Inestrosa NC. Release of acetylcholinesterase (AChE) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice. Chemico-Biological Interactions. 175: 142-9. PMID 18599028 DOI: 10.1016/j.cbi.2008.05.026  1
2008 Cancino GI, Toledo EM, Leal NR, Hernandez DE, Yévenes LF, Inestrosa NC, Alvarez AR. STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits. Brain : a Journal of Neurology. 131: 2425-42. PMID 18559370 DOI: 10.1093/brain/awn125  1
2008 Cerpa W, Dinamarca MC, Inestrosa NC. Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapses. Current Alzheimer Research. 5: 233-43. PMID 18537540 DOI: 10.2174/156720508784533321  1
2008 Chacón MA, Varela-Nallar L, Inestrosa NC. Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers. Journal of Cellular Physiology. 217: 215-27. PMID 18521822 DOI: 10.1002/jcp.21497  1
2008 Colombres M, Henríquez JP, Reig GF, Scheu J, Calderón R, Alvarez A, Brandan E, Inestrosa NC. Heparin activates Wnt signaling for neuronal morphogenesis. Journal of Cellular Physiology. 216: 805-15. PMID 18449906 DOI: 10.1002/jcp.21465  1
2008 Dinamarca MC, Colombres M, Cerpa W, Bonansco C, Inestrosa NC. Beta-amyloid oligomers affect the structure and function of the postsynaptic region: role of the Wnt signaling pathway. Neuro-Degenerative Diseases. 5: 149-52. PMID 18322375 DOI: 10.1159/000113687  1
2008 Inestrosa NC, Dinamarca MC, Alvarez A. Amyloid-cholinesterase interactions: Implications for Alzheimer's disease Febs Journal. 275: 625-632. PMID 18205831 DOI: 10.1111/j.1742-4658.2007.06238.x  1
2008 Cerpa W, Godoy JA, Alfaro I, Farías GG, Metcalfe MJ, Fuentealba R, Bonansco C, Inestrosa NC. Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. The Journal of Biological Chemistry. 283: 5918-27. PMID 18096705 DOI: 10.1074/jbc.M705943200  1
2007 Fuenzalida K, Quintanilla R, Ramos P, Piderit D, Fuentealba RA, Martinez G, Inestrosa NC, Bronfman M. Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. The Journal of Biological Chemistry. 282: 37006-15. PMID 17965419 DOI: 10.1074/jbc.M700447200  1
2007 Fuentealba RA, Barría MI, Lee J, Cam J, Araya C, Escudero CA, Inestrosa NC, Bronfman FC, Bu G, Marzolo MP. ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity. Molecular Neurodegeneration. 2: 14. PMID 17620134 DOI: 10.1186/1750-1326-2-14  1
2007 Farías GG, Vallés AS, Colombres M, Godoy JA, Toledo EM, Lukas RJ, Barrantes FJ, Inestrosa NC. Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 5313-25. PMID 17507554 DOI: 10.1523/JNEUROSCI.3934-06.2007  1
2007 Inestrosa NC, Varela-Nallar L, Grabowski CP, Colombres M. Synaptotoxicity in Alzheimer's disease: The Wnt signaling pathway as a molecular target Iubmb Life. 59: 316-321. PMID 17505971 DOI: 10.1080/15216540701242490  1
2006 Dinamarca MC, Cerpa W, Garrido J, Hancke JL, Inestrosa NC. Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits. Molecular Psychiatry. 11: 1032-48. PMID 16880827 DOI: 10.1038/sj.mp.4001866  1
2006 Varela-Nallar L, González A, Inestrosa NC. Role of copper in prion diseases: Deleterious or beneficial? Current Pharmaceutical Design. 12: 2587-2595. PMID 16842180 DOI: 10.2174/138161206777698873  1
2006 Varela-Nallar L, Toledo EM, Chacón MA, Inestrosa NC. The functional links between prion protein and copper. Biological Research. 39: 39-44. PMID 16629163  1
2006 Kemmerling U, Cabrera G, Campos EO, Inestrosa NC, Galanti N. Localization, specific activity, and molecular forms of acetylcholinesterase in developmental stages of the cestode Mesocestoides corti Journal of Cellular Physiology. 206: 503-509. PMID 16155922 DOI: 10.1002/jcp.20495  1
2006 Varela-Nallar L, Toledo EM, Larrondo LF, Cabral ALB, Martins VR, Inestrosa NC. Induction of cellular prion protein gene expression by copper in neurons American Journal of Physiology - Cell Physiology. 290: C271-C281. PMID 16148034 DOI: 10.1152/ajpcell.00160.2005  1
2006 Inestrosa NC, Farías G, Colombres M. Glycogen Synthase Kinase 3β (GSK-3β) a Key Signaling Enzyme: A Developmental Neurobiological Perspective Glycogen Synthase Kinase 3 (Gsk-3) and Its Inhibitors: Drug Discovery and Development. 25-43. DOI: 10.1002/9780470052174.ch2  1
2005 Santos MJ, Quintanilla RA, Toro A, Grandy R, Dinamarca MC, Godoy JA, Inestrosa NC. Peroxisomal proliferation protects from beta-amyloid neurodegeneration. The Journal of Biological Chemistry. 280: 41057-68. PMID 16204253 DOI: 10.1074/jbc.M505160200  1
2005 Inestrosa NC, Cerpa W, Varela-Nallar L. Copper brain homeostasis: role of amyloid precursor protein and prion protein. Iubmb Life. 57: 645-50. PMID 16203684 DOI: 10.1080/15216540500264620  1
2005 Cerpa W, Varela-Nallar L, Reyes AE, Minniti AN, Inestrosa NC. Is there a role for copper in neurodegenerative diseases? Molecular Aspects of Medicine. 26: 405-20. PMID 16112188 DOI: 10.1016/j.mam.2005.07.011  1
2005 Cuitino L, Matute R, Retamal C, Bu G, Inestrosa NC, Marzolo MP. ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association. Traffic (Copenhagen, Denmark). 6: 820-38. PMID 16101684 DOI: 10.1111/j.1600-0854.2005.00320.x  1
2005 Inestrosa NC, Alvarez A, Dinamarca MC, Pérez-Acle T, Colombres M. Acetylcholinesterase-amyloid-β-peptide interaction: Effect of Congo Red and the role of the Wnt pathway Current Alzheimer Research. 2: 301-306. PMID 15974895 DOI: 10.2174/1567205054367928  1
2005 Inestrosa NC, Reyes AE, Chacón MA, Cerpa W, Villalón A, Montiel J, Merabachvili G, Aldunate R, Bozinovic F, Aboitiz F. Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu. Neurobiology of Aging. 26: 1023-8. PMID 15748782 DOI: 10.1016/j.neurobiolaging.2004.09.016  1
2005 Inestrosa NC, Sagal JP, Colombres M. Acetylcholinesterase interaction with Alzheimer amyloid beta Sub-Cellular Biochemistry. 38: 299-317. PMID 15709485  1
2005 Inestrosa NC, Godoy JA, Quintanilla RA, Koenig CS, Bronfman M. Peroxisome proliferator-activated receptor γ is expressed in hippocampal neurons and its activation prevents β-amyloid neurodegeneration: Role of Wnt signaling Experimental Cell Research. 304: 91-104. PMID 15707577 DOI: 10.1016/j.yexcr.2004.09.032  1
2005 Von Bernhardi R, Alarcón R, Mezzano D, Fuentes P, Inestrosa NC. Blood cells cholinesterase activity in early stage Alzheimer's disease and vascular dementia Dementia and Geriatric Cognitive Disorders. 19: 204-212. PMID 15677868 DOI: 10.1159/000083500  1
2005 Quintanilla RA, Muñoz FJ, Metcalfe MJ, Hitschfeld M, Olivares G, Godoy JA, Inestrosa NC. Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway. The Journal of Biological Chemistry. 280: 11615-25. PMID 15659394 DOI: 10.1074/jbc.M411936200  1
2005 Farías GG, Godoy JA, Vázquez MC, Adani R, Meshulam H, Avila J, Amitai G, Inestrosa NC. The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from β-amyloid neurotoxicity by acting on Wnt signaling components Neurobiology of Disease. 18: 176-183. PMID 15649708 DOI: 10.1016/j.nbd.2004.09.012  1
2004 Inestrosa NC, Urra S, Colombres M. Acetylcholinesterase (AChE)--amyloid-beta-peptide complexes in Alzheimer's disease. the Wnt signaling pathway Curr Alzheimer Res. 1: 249-254. PMID 15975054  1
2004 Morgan C, Colombres M, Nuñez MT, Inestrosa NC. Structure and function of amyloid in Alzheimer's disease Progress in Neurobiology. 74: 323-349. PMID 15649580 DOI: 10.1016/j.pneurobio.2004.10.004  1
2004 Fuentealba RA, Farias G, Scheu J, Bronfman M, Marzolo MP, Inestrosa NC. Signal transduction during amyloid-β-peptide neurotoxicity: Role in Alzheimer disease Brain Research Reviews. 47: 275-289. PMID 15572177 DOI: 10.1016/j.brainresrev.2004.07.018  1
2004 Aldunate R, Casar JC, Brandan E, Inestrosa NC. Structural and functional organization of synaptic acetylcholinesterase Brain Research Reviews. 47: 96-104. PMID 15572165 DOI: 10.1016/j.brainresrev.2004.07.019  1
2004 Colombres M, Sagal JP, Inestrosa NC. An overview of the current and novel drugs for Alzheimer's disease with particular reference to anti-cholinesterase compounds Current Pharmaceutical Design. 10: 3121-3130. PMID 15544502 DOI: 10.2174/1381612043383359  1
2004 Farías GG, Godoy JA, Hernández F, Avila J, Fisher A, Inestrosa NC. M1 muscarinic receptor activation protects neurons from β-amyloid toxicity. A role for Wnt signaling pathway Neurobiology of Disease. 17: 337-348. PMID 15474371 DOI: 10.1016/j.nbd.2004.07.016  1
2004 Cerpa WF, Barría MI, Chacón MA, Suazo M, González M, Opazo C, Bush AI, Inestrosa NC. The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1701-3. PMID 15345692 DOI: 10.1096/fj.03-1349fje  1
2004 Alvarez AR, Godoy JA, Mullendorff K, Olivares GH, Bronfman M, Inestrosa NC. Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons. Experimental Cell Research. 297: 186-96. PMID 15194435 DOI: 10.1016/j.yexcr.2004.02.028  1
2004 Reyes AE, Chacón MA, Dinamarca MC, Cerpa W, Morgan C, Inestrosa NC. Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss. The American Journal of Pathology. 164: 2163-74. PMID 15161650  1
2004 Doss-Pepe E, Deprez P, Silva T, Inestrosa NC, Kirkpatrick A, Ramshaw JAM, Brodsky B. Stepwise construction of triple-helical heparin binding sites using peptide models Biochimica Et Biophysica Acta - Proteins and Proteomics. 1698: 187-195. PMID 15134651 DOI: 10.1016/j.bbapap.2003.11.034  1
2004 Chacón MA, Barría MI, Soto C, Inestrosa NC. Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits. Molecular Psychiatry. 9: 953-61. PMID 15098004 DOI: 10.1038/sj.mp.4001516  1
2004 Casar JC, Cabello-Verrugio C, Olguin H, Aldunate R, Inestrosa NC, Brandan E. Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: Requirement of syndecan-3 for successful fiber formation Journal of Cell Science. 117: 73-84. PMID 14627628 DOI: 10.1242/jcs.00828  1
2003 Von Bernhardi R, Ramírez G, De Ferrari GV, Inestrosa NC. Acetylcholinesterase induces the expression of the β-amyloid precursor protein in glia and activates glial cells in culture Neurobiology of Disease. 14: 447-457. PMID 14678761 DOI: 10.1016/j.nbd.2003.08.014  1
2003 Chacón MA, Barría MI, Lorca R, Huidobro-Toro JP, Inestrosa NC. A human prion protein peptide (PrP(59-91)) protects against copper neurotoxicity. Molecular Psychiatry. 8: 853-62, 835. PMID 14515136 DOI: 10.1038/sj.mp.4001400  1
2003 Chacón MA, Reyes AE, Inestrosa NC. Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus. Journal of Neurochemistry. 87: 195-204. PMID 12969266 DOI: 10.1046/j.1471-4159.2003.01985.x  1
2003 Roth AD, Leisewitz AV, Jung JE, Cassina P, Barbeito L, Inestrosa NC, Bronfman M. PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes. Journal of Neuroscience Research. 72: 425-35. PMID 12704804 DOI: 10.1002/jnr.10596  1
2003 Lorca RA, Chacón M, Barría MI, Inestrosa NC, Huidobro-Toro JP. The human prion octarepeat fragment prevents and reverses the inhibitory action of copper in the P2X4 receptor without modifying the zinc action. Journal of Neurochemistry. 85: 709-16. PMID 12694397  1
2003 Deprez P, Inestrosa NC, Krejci E. Two different heparin-binding domains in the triple-helical domain of ColQ, the collagen tail subunit of synaptic acetylcholinesterase Journal of Biological Chemistry. 278: 23233-23242. PMID 12684510 DOI: 10.1074/jbc.M301384200  1
2003 Leisewitz AV, Jung JE, Perez-Alzola P, Fuenzalida KM, Roth A, Inestrosa NC, Bronfman M. Ethanol specifically decreases peroxisome proliferator activated receptor β in B12 oligodendrocyte-like cells Journal of Neurochemistry. 85: 135-141. PMID 12641735  1
2003 De Ferrari GV, Chacón MA, Barría MI, Garrido JL, Godoy JA, Olivares G, Reyes AE, Alvarez A, Bronfman M, Inestrosa NC. Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. Molecular Psychiatry. 8: 195-208. PMID 12610652 DOI: 10.1038/sj.mp.4001208  1
2003 Opazo C, Inés Barría M, Ruiz FH, Inestrosa NC. Copper reduction by copper binding proteins and its relation to neurodegenerative diseases Biometals. 16: 91-98. PMID 12572668 DOI: 10.1023/A:1020795422185  1
2003 Chacón MA, Barría MI, Lorca R, Huidobro-Toro JP, Inestrosa NC. A human prion protein peptide (PrP59-91) protects against copper neurotoxicity Molecular Psychiatry. 8: 835+833.  1
2002 Garrido JL, Godoy JA, Alvarez A, Bronfman M, Inestrosa NC. Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1982-1984. PMID 12397090  1
2002 Opazo C, Huang X, Cherny RA, Moir RD, Roher AE, White AR, Cappai R, Masters CL, Tanzi RE, Inestrosa NC, Bush AI. Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). The Journal of Biological Chemistry. 277: 40302-8. PMID 12192006 DOI: 10.1074/jbc.M206428200  1
2002 Inestrosa N, De Ferrari GV, Garrido JL, Alvarez A, Olivares GH, Barría MI, Bronfman M, Chacón MA. Wnt signaling involvement in beta-amyloid-dependent neurodegeneration. Neurochemistry International. 41: 341-4. PMID 12176076 DOI: 10.1016/S0197-0186(02)00056-6  1
2002 Morgan C, Bugueño MP, Garrido J, Inestrosa NC. Laminin affects polymerization, depolymerization and neurotoxicity of Aβ peptide Peptides. 23: 1229-1240. PMID 12128080 DOI: 10.1016/S0196-9781(02)00058-X  1
2002 Muñoz FJ, Opazo C, Gil-Gómez G, Tapia G, Fernández V, Valverde MA, Inestrosa NC. Vitamin E but not 17beta-estradiol protects against vascular toxicity induced by beta-amyloid wild type and the Dutch amyloid variant. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3081-9. PMID 11943811  1
2001 De Ferrari GV, Canales MA, Shin I, Weiner LM, Silman I, Inestrosa NC. A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation. Biochemistry. 40: 10447-57. PMID 11523986 DOI: 10.1021/bi0101392  1
2001 Morgan C, Inestrosa NC. Interactions of laminin with the amyloid ß peptide. Implications for Alzheimer's disease Brazilian Journal of Medical and Biological Research. 34: 597-601. PMID 11323745  1
2001 De Ferrari GV, Mallender WD, Inestrosa NC, Rosenberry TL. Thioflavin T Is a Fluorescent Probe of the Acetylcholinesterase Peripheral Site That Reveals Conformational Interactions between the Peripheral and Acylation Sites Journal of Biological Chemistry. 276: 23282-23287. PMID 11313335 DOI: 10.1074/jbc.M009596200  1
2000 Opazo C, Ruiz FH, Inestrosa NC. Amyloid-β-peptide reduces copper(II) to copper(I) independent of its aggregation state Biological Research. 33: 125-131. PMID 15693279  1
2000 Inestrosa NC, Alvarez A, Godoy J, Reyes A, De Ferrari GV. Acetylcholinesterase-amyloid-β-peptide interaction and Wnt signaling involvement in Aβ neurotoxicity Acta Neurologica Scandinavica, Supplement. 102: 53-59. PMID 11261806  1
2000 Doss-Pepe E, Deprez P, Inestrosa NC, Brodsky B. Interaction of collagen-like peptide models of asymmetric acetylcholinesterase with glycosaminoglycans: Spectroscopic studies of conformational changes and stability Biochemistry. 39: 14884-14892. PMID 11101304 DOI: 10.1021/bi001108u  1
2000 De Ferrari and GV, Inestrosa NC. Wnt signaling function in Alzheimer's disease Brain Research Reviews. 33: 1-12. PMID 10967351 DOI: 10.1016/S0165-0173(00)00021-7  1
2000 Deprez P, Doss-Pepe E, Brodsky B, Inestrosa NC. Interaction of the collagen-like tail of asymmetric acetylcholinesterase with heparin depends on triple-helical conformation, sequence and stability Biochemical Journal. 350: 283-290. PMID 10926855 DOI: 10.1042/0264-6021:3500283  1
2000 Miranda S, Opazo C, Larrondo LF, Muñoz FJ, Ruiz F, Leighton F, Inestrosa NC. The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer's disease Progress in Neurobiology. 62: 633-648. PMID 10880853 DOI: 10.1016/S0301-0082(00)00015-0  1
2000 Marzolo MP, Von Bernhardi R, Bu G, Inestrosa NC. Expression of α2-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells Journal of Neuroscience Research. 60: 401-411. PMID 10797543 DOI: 10.1002/(SICI)1097-4547(20000501)60:3<401::AID-JNR15>3.0.CO;2-L  1
2000 Ruiz FH, Silva E, Inestrosa NC. The N-terminal tandem repeat region of human prion protein reduces copper: Role of tryptophan residues Biochemical and Biophysical Research Communications. 269: 491-495. PMID 10708581 DOI: 10.1006/bbrc.2000.2270  1
2000 Deprez P, Inestrosa NC. Molecular modeling of the collagen-like tail of asymmetric acetylcholinesterase Protein Engineering. 13: 27-34. PMID 10679527  1
1999 Muñoz FJ, Aldunate R, Inestrosa NC. Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase Neuroreport. 10: 3621-3625. PMID 10619655  1
1999 Contreras CF, Canales MA, Alvarez A, De Ferrari GV, Inestrosa NC. Molecular modeling of the amyloid-β-peptide using the homology to a fragment of triosephosphate isomerase that forms amyloid in vitro Protein Engineering. 12: 959-966. PMID 10585501  1
1999 Marzolo MP, Von Bernhardi R, Inestrosa NC. Mannose receptor is present in a functional state in rat microglial cells Journal of Neuroscience Research. 58: 387-395. PMID 10518112 DOI: 10.1002/(SICI)1097-4547(19991101)58:3<387::AID-JNR4>3.0.CO;2-L  1
1995 Rodriguez SR, Riquelme C, Campos EO, Chavez P, Brandan E, Inestrosa NC. Behavioral Responses of Concholepas concholepas (Bruguière, 1789) Larvae to Natural and Artificial Settlement Cues and Microbial Films. The Biological Bulletin. 189: 272-279. PMID 29244580 DOI: 10.2307/1542144  1
1993 Brandan E, Inestrosa NC. Extracellular matrix components and amyloid in neuritic plaques of Alzheimer's disease. General Pharmacology. 24: 1063-8. PMID 8270163 DOI: 10.1016/0306-3623(93)90350-7  1
1993 Krauss RY, Alvarez J, Inestrosa NC. A neurofilament polypeptide and the glial fibrillary acidic protein share common epitopes in the variable region. Neuroscience Letters. 161: 137-40. PMID 7505907  0.52
1992 Gonzalez R, Urrea R, Gonzalez M, Inestrosa NC, Brandan E. Isolation of proteoglycans synthesized by rat heart: evidence for the presence of several distinct forms. General Pharmacology. 23: 249-55. PMID 1639240 DOI: 10.1016/0306-3623(92)90020-K  1
1992 Brandan E, González M, Inestrosa NC, Tremblay C, Urrea R. A high molecular weight proteoglycan is differentially expressed during development of the mollusc Concholepas concholepas (Mollusca; Gastropoda; Muricidae). The Journal of Experimental Zoology. 264: 363-71. PMID 1460434 DOI: 10.1002/jez.1402640402  1
1992 Alvarez J, Moreno RD, Llanos O, Inestrosa NC, Brandan E, Colby T, Esch FS. Axonal sprouting induced in the sciatic nerve by the amyloid precursor protein (APP) and other antiproteases. Neuroscience Letters. 144: 130-4. PMID 1436693 DOI: 10.1016/0304-3940(92)90733-N  1
1990 Fadic R, Brandan E, Inestrosa NC. Motor nerve regulates muscle extracellular matrix proteoglycan expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 3516-23. PMID 2230941  1
1990 Perelman A, Abeijon C, Hirschberg CB, Inestrosa NC, Brandan E. Differential association and distribution of acetyl- and butyrylcholinesterases within rat liver subcellular organelles. The Journal of Biological Chemistry. 265: 214-20. PMID 2152920  1
1990 Inestrosa NC, Labarca R, Perelman A, Campos EO, Araneda R, Gonzalez M, Brandan E, Sanchez JP, Gonzalez-Plaza R. Biotechnological aspects in loco larvae Archivos De Biologia Y Medicina Experimentales. 23: 179-186. PMID 1966831  1
1989 Allende ML, Krauss RY, Tremblay C, Alvarez J, Inestrosa NC. Anti-200 kDa neurofilament antibody cross-reacts with microtubule-associated protein-2 (MAP-2). Journal of Neuroscience Research. 22: 130-3. PMID 2468783 DOI: 10.1002/jnr.490220204  1
1987 Brandan E, Inestrosa NC. Co-solubilization of asymmetric acetylcholinesterase and dermatan sulfate proteoglycan from the extracellular matrix of rat skeletal muscles. Febs Letters. 213: 159-63. PMID 3556575 DOI: 10.1016/0014-5793(87)81483-7  1
1987 Brandan E, Inestrosa NC. Isolation of the heparan sulfate proteoglycans from the extracellular matrix of rat skeletal muscle. Journal of Neurobiology. 18: 271-82. PMID 2955079 DOI: 10.1002/neu.480180303  1
1987 Cross D, Allende ML, Krauss RY, Fuentes ME, Kaltwasser G, Alvarez J, Inestrosa NC. Biosynthesis of the neurofilament heavy subunit in Xenopus oocytes microinjected with rat brain poly(A)+ RNA. Molecular Biology Reports. 12: 265-71. PMID 2893252 DOI: 10.1007/BF00444678  1
1987 Inestrosa NC, Nader HB, Garrido J, Sampaio LO, Brandan E, Dietrich CP. Glycosaminoglycan composition of electric organ basement membranes. Journal of Neuroscience Research. 17: 256-64. PMID 2439701 DOI: 10.1002/jnr.490170309  1
1986 Brandan E, Llona I, Inestrosa NC. Heparin-acetylcholinesterase interaction: Specific detachment of class I-A forms and binding of class I and II-A forms to heparin-agarose. Neurochemistry International. 9: 75-84. PMID 20493103 DOI: 10.1016/0197-0186(86)90034-3  1
1986 Brandan E, Inestrosa NC. The synaptic form of acetylcholinesterase binds to cell-surface heparan sulfate proteoglycans. Journal of Neuroscience Research. 15: 185-96. PMID 2937928 DOI: 10.1002/jnr.490150208  1
1985 Brandan E, Maldonado M, Garrido J, Inestrosa NC. Anchorage of collagen-tailed acetylcholinesterase to the extracellular matrix is mediated by heparan sulfate proteoglycans. The Journal of Cell Biology. 101: 985-92. PMID 3161900  1
1985 Inestrosa NC, Matthew WD, Reiness CG, Hall ZW, Reichardt LF. Atypical distribution of asymmetric acetylcholinesterase in mutant PC12 pheochromocytoma cells lacking a cell surface heparan sulfate proteoglycan. Journal of Neurochemistry. 45: 86-94. PMID 3158721 DOI: 10.1111/j.1471-4159.1985.tb05478.x  1
1984 Ziskind-Conhaim L, Inestrosa NC, Hall ZW. Acetylcholinesterase is functional in embryonic rat muscle before its accumulation at the sites of nerve-muscle contact. Developmental Biology. 103: 369-77. PMID 6202574 DOI: 10.1016/0012-1606(84)90325-7  1
1984 Brandan E, Inestrosa NC. Binding of the asymmetric forms of acetylcholinesterase to heparin. The Biochemical Journal. 221: 415-22. PMID 6089739  1
1983 Inestrosa NC, Miller JB, Silberstein L, Ziskind-Conhaim L, Hall ZW. Developmental regulation of 16S acetylcholinesterase and acetylcholine receptors in a mouse muscle cell line. Experimental Cell Research. 147: 393-405. PMID 6617773 DOI: 10.1016/0014-4827(83)90221-5  1
1982 Silberstein L, Inestrosa NC, Hall ZW. Aneural muscle cell cultures make synaptic basal lamina components. Nature. 295: 143-5. PMID 7035963 DOI: 10.1038/295143a0  1
1982 Inestrosa NC, Silberstein L, Hall ZW. Association of the synaptic form of acetylcholinesterase with extracellular matrix in cultured mouse muscle cells. Cell. 29: 71-9. PMID 6286145 DOI: 10.1016/0092-8674(82)90091-5  1
1981 Inestrosa NC, Reiness CG, Reichardt LF, Hall ZW. Cellular localization of the molecular forms of acetylcholinesterase in rat pheochromocytoma PC12 cells treated with nerve growth factor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 1: 1260-7. PMID 7310486  1
1979 Inestrosa NC, Mendez B, Luco JV. Acetylcholinesterase like that of skeletal muscle in smooth muscle reinnervated by a motor nerve. Nature. 280: 504-6. PMID 460431 DOI: 10.1038/280504a0  1
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