Samuel H. Wilson - Publications

Affiliations: 
Structural Biology NIEHS/NIH, Durham, NC, United States 

383 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Zhao ML, Stefanick DF, Nadalutti CA, Beard WA, Wilson SH, Horton JK. Temporal recruitment of base excision DNA repair factors in living cells in response to different micro-irradiation DNA damage protocols. Dna Repair. 126: 103486. PMID 37028218 DOI: 10.1016/j.dnarep.2023.103486  0.426
2022 Chandramouly G, Jamsen J, Borisonnik N, Tyagi M, Calbert ML, Tredinnick T, Ozdemir AY, Kent T, Demidova EV, Arora S, Wilson SH, Pomerantz RT. Polλ promotes microhomology-mediated end-joining. Nature Structural & Molecular Biology. PMID 36536104 DOI: 10.1038/s41594-022-00895-4  0.399
2022 Rodriguez Y, Butay KJ, Sharma K, Viverette E, Wilson SH. Preparation of Nucleosome Core Particles Complexed with DNA Repair Factors for Cryo-Electron Microscopy Structural Determination. Journal of Visualized Experiments : Jove. PMID 36063009 DOI: 10.3791/64061  0.434
2022 Jamsen JA, Shock DD, Wilson SH. Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints. Nature Communications. 13: 3193. PMID 35680862 DOI: 10.1038/s41467-022-30141-w  0.41
2022 Prasad R, Horton JK, Wilson SH. Withdrawal notice to "Requirements for PARP-1 covalent crosslinking to DNA (PARP-1 DPC)". Dna Repair. 114: 103322. PMID 35338996 DOI: 10.1016/j.dnarep.2022.103322  0.421
2021 Jamsen JA, Sassa A, Perera L, Shock DD, Beard WA, Wilson SH. Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair. Nature Communications. 12: 5055. PMID 34417448 DOI: 10.1038/s41467-021-24486-x  0.555
2021 Jamsen JA, Sassa A, Shock DD, Beard WA, Wilson SH. Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nature Communications. 12: 2059. PMID 33824325 DOI: 10.1038/s41467-021-21354-6  0.401
2020 Liu Y, Rodriguez Y, Ross RL, Zhao R, Watts JA, Grunseich C, Bruzel A, Li D, Burdick JT, Prasad R, Crouch RJ, Limbach PA, Wilson SH, Cheung VG. RNA abasic sites in yeast and human cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 32788345 DOI: 10.1073/Pnas.2011511117  0.326
2020 Howard MJ, Horton JK, Zhao ML, Wilson SH. Lysines in the lyase active site of DNA polymerase β destabilize non-specific DNA binding, facilitating searching and DNA gap recognition. The Journal of Biological Chemistry. PMID 32647014 DOI: 10.1074/Jbc.Ra120.013547  0.539
2020 Perera L, Beard WA, Pedersen LG, Shock DD, Wilson SH. Preferential DNA Polymerase β Reverse Reaction with Imidodiphosphate. Acs Omega. 5: 15317-15324. PMID 32637805 DOI: 10.1021/acsomega.0c01345  0.705
2020 Batra VK, Wilson SH. Structure of a DNA polymerase abortive complex with the 8OG:dA base pair at the primer terminus. Communications Biology. 3: 348. PMID 32620932 DOI: 10.1038/s42003-020-1080-4  0.333
2020 Saha LK, Wakasugi M, Akter S, Prasad R, Wilson SH, Shimizu N, Sasanuma H, Huang SN, Agama K, Pommier Y, Matsunaga T, Hirota K, Iwai S, Nakazawa Y, Ogi T, et al. Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 32513688 DOI: 10.1073/Pnas.1920165117  0.473
2020 Prasad R, Horton JK, Wilson SH. Requirements for PARP-1 covalent crosslinking to DNA (PARP-1 DPC). Dna Repair. 90: 102850. PMID 32438305 DOI: 10.1016/j.dnarep.2020.102850  0.427
2020 Nadalutti CA, Stefanick DF, Zhao ML, Horton JK, Prasad R, Brooks AM, Griffith JD, Wilson SH. Mitochondrial dysfunction and DNA damage accompany enhanced levels of formaldehyde in cultured primary human fibroblasts. Scientific Reports. 10: 5575. PMID 32221313 DOI: 10.1038/S41598-020-61477-2  0.382
2020 Prasad R, Horton JK, Wilson SH. Requirements for PARP-1 covalent crosslinking to DNA (PARP-1 DPC). Dna Repair. 89: 102824. PMID 32151818 DOI: 10.1016/J.Dnarep.2020.102824  0.521
2020 Batra VK, Alnajjar KS, Sweasy JB, McKenna CE, Goodman MF, Wilson SH. Revealing an internal stabilization deficiency in the DNA polymerase β K289M cancer variant through combined use of chemical biology and X-ray crystallography. Biochemistry. PMID 31999437 DOI: 10.1021/Acs.Biochem.9B01072  0.408
2020 Jiang Z, Lai Y, Beaver JM, Tsegay PS, Zhao ML, Horton JK, Zamora M, Rein HL, Miralles F, Shaver M, Hutcheson JD, Agoulnik I, Wilson SH, Liu Y. Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a DNA Methyltransferase. Cells. 9. PMID 31963223 DOI: 10.3390/Cells9010225  0.53
2020 Quiñones JL, Thapar U, Wilson SH, Ramsden DA, Demple B. Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair. Dna Repair. 87: 102773. PMID 31945542 DOI: 10.1016/J.Dnarep.2019.102773  0.49
2019 Howard MJ, Cavanaugh NA, Batra VK, Shock DD, Beard WA, Wilson SH. DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context. The Journal of Biological Chemistry. PMID 31801827 DOI: 10.1074/Jbc.Ra119.010594  0.539
2019 Janoshazi AK, Horton JK, Zhao ML, Prasad R, Scappini EL, Tucker CJ, Wilson SH. Shining light on the response to repair intermediates in DNA of living cells. Dna Repair. 85: 102749. PMID 31790865 DOI: 10.1016/J.Dnarep.2019.102749  0.501
2019 Beard WA, Wilson SH. DNA polymerase beta and other gap-filling enzymes in mammalian base excision repair. The Enzymes. 45: 1-26. PMID 31627875 DOI: 10.1016/Bs.Enz.2019.08.002  0.574
2019 Rodriguez Y, Horton JK, Wilson SH. Histone H3 lysine 56 acetylation enhances AP endonuclease 1-mediated repair of AP sites in nucleosome core particles. Biochemistry. PMID 31407575 DOI: 10.1021/Acs.Biochem.9B00433  0.418
2019 Jang S, Kumar N, Beckwitt EC, Kong M, Fouquerel E, Rapić-Otrin V, Prasad R, Watkins SC, Khuu C, Majumdar C, David SS, Wilson SH, Bruchez MP, Opresko PL, Van Houten B. Damage sensor role of UV-DDB during base excision repair. Nature Structural & Molecular Biology. PMID 31332353 DOI: 10.1038/S41594-019-0261-7  0.523
2019 Dai DP, Prasad R, Strauss PR, Wilson SH. The Pol β variant containing exon α is deficient in DNA polymerase but has full dRP lyase activity. Scientific Reports. 9: 9928. PMID 31289286 DOI: 10.1038/S41598-019-45846-0  0.391
2019 Beard WA, Horton JK, Prasad R, Wilson SH. Eukaryotic Base Excision Repair: New Approaches Shine Light on Mechanism. Annual Review of Biochemistry. 88: 137-162. PMID 31220977 DOI: 10.1146/Annurev-Biochem-013118-111315  0.52
2019 Howard MJ, Foley KG, Shock DD, Batra VK, Wilson SH. Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA Polymerase ß. The Journal of Biological Chemistry. PMID 30885943 DOI: 10.1074/jbc.RA118.006809  0.455
2019 Oertell K, Florian J, Haratipour P, Crans DC, Kashemirov BA, Wilson SH, McKenna CE, Goodman MF. A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β. Biochemistry. PMID 30839203 DOI: 10.1021/Acs.Biochem.9B00087  0.432
2019 Smith MR, Shock DD, Beard WA, Greenberg MM, Freudenthal BD, Wilson SH. A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition. Nucleic Acids Research. PMID 30649431 DOI: 10.1093/nar/gkz002  0.527
2018 Prasad R, Horton JK, Dai DP, Wilson SH. Repair pathway for PARP-1 DNA-protein crosslinks. Dna Repair. PMID 30466837 DOI: 10.1016/J.Dnarep.2018.11.004  0.541
2018 Çağlayan M, Wilson SH. Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate. Nature Communications. 9: 4213. PMID 30310068 DOI: 10.1038/S41467-018-06700-5  0.514
2018 Howard MJ, Wilson SH. DNA scanning by base excision repair enzymes and implications for pathway coordination. Dna Repair. PMID 30181039 DOI: 10.1016/J.Dnarep.2018.08.013  0.53
2018 DeRose EF, Kirby TW, Mueller GA, Beard WA, Wilson SH, London RE. Transitions in DNA polymerase β μs-ms dynamics related to substrate binding and catalysis. Nucleic Acids Research. PMID 29917149 DOI: 10.1093/Nar/Gky503  0.476
2018 Oertell K, Kashemirov BA, Negahbani A, Minard C, Haratipour P, Alnajjar KS, Sweasy JB, Batra VK, Beard WA, Wilson SH, McKenna CE, Goodman MF. Probing DNA base-dependent leaving group kinetic effects on the DNA polymerase transition state. Biochemistry. PMID 29889506 DOI: 10.1021/Acs.Biochem.8B00417  0.442
2018 Batra VK, Oertell K, Beard WA, Kashemirov BA, McKenna CE, Goodman MF, Wilson SH. Mapping functional substrate-enzyme interactions in the pol β active site through chemical biology: Structural responses to acidity modification of incoming dNTPs. Biochemistry. PMID 29874056 DOI: 10.1021/Acs.Biochem.8B00418  0.449
2018 Horton JK, Stefanick DF, Çağlayan M, Zhao ML, Janoshazi AK, Prasad R, Gassman NR, Wilson SH. XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activity. Dna Repair. 64: 26-33. PMID 29477978 DOI: 10.1016/J.Dnarep.2018.02.004  0.461
2018 DeRose E, Kirby T, Mueller G, Beard W, Wilson S, London R. Ile and Met methyl 1H and 13C chemical shifts of DNA polymerase beta Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr27407  0.389
2017 Liu L, Kong M, Gassman NR, Freudenthal BD, Prasad R, Zhen S, Watkins SC, Wilson SH, Van Houten B. PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1. Nucleic Acids Research. PMID 29121337 DOI: 10.1093/Nar/Gkx1047  0.513
2017 Prasad R, Çağlayan M, Dai DP, Nadalutti CA, Zhao ML, Gassman NR, Janoshazi AK, Stefanick DF, Horton JK, Krasich R, Longley MJ, Copeland WC, Griffith JD, Wilson SH. DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria. Dna Repair. 60: 77-88. PMID 29100041 DOI: 10.1016/J.Dnarep.2017.10.011  0.461
2017 Horton JK, Stefanick DF, Zhao ML, Janoshazi AK, Gassman NR, Seddon HJ, Wilson SH. XRCC1-mediated repair of strand breaks independent of PNKP binding. Dna Repair. 60: 52-63. PMID 29100039 DOI: 10.1016/J.Dnarep.2017.10.007  0.527
2017 Çaglayan M, Wilson SH. Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure. Journal of Radiation Research. 1-5. PMID 28992331 DOI: 10.1093/Jrr/Rrx027  0.481
2017 Çaglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC, Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. Nucleic Acids Research. 45: 10079-10088. PMID 28973450 DOI: 10.1093/Nar/Gkx654  0.399
2017 Rodriguez Y, Howard MJ, Cuneo MJ, Prasad R, Wilson SH. Unencumbered Pol β lyase activity in nucleosome core particles. Nucleic Acids Research. 45: 8901-8915. PMID 28911106 DOI: 10.1093/Nar/Gkx593  0.52
2017 Howard MJ, Wilson SH. Processive searching ability varies among members of the gap-filling DNA polymerase X family. The Journal of Biological Chemistry. PMID 28893909 DOI: 10.1074/Jbc.M117.801860  0.531
2017 Çağlayan M, Wilson SH. In vitro Assay to Measure DNA Polymerase β Nucleotide Insertion Coupled with the DNA Ligation Reaction during Base Excision Repair. Bio-Protocol. 7. PMID 28835905 DOI: 10.21769/BioProtoc.2341  0.437
2017 Jamsen JA, Beard WA, Pedersen LC, Shock DD, Moon AF, Krahn JM, Bebenek K, Kunkel TA, Wilson SH. Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nature Communications. 8: 253. PMID 28811466 DOI: 10.1038/S41467-017-00271-7  0.493
2017 Shock DD, Freudenthal BD, Beard WA, Wilson SH. Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction. Nature Chemical Biology. PMID 28759020 DOI: 10.1038/Nchembio.2450  0.446
2017 Horton JK, Seddon HJ, Zhao ML, Gassman NR, Janoshazi AK, Stefanick DF, Wilson SH. Role of the oxidized form of XRCC1 in protection against extreme oxidative stress. Free Radical Biology & Medicine. PMID 28179111 DOI: 10.1016/J.Freeradbiomed.2017.02.005  0.438
2017 Howard MJ, Rodriguez Y, Wilson SH. DNA polymerase β uses its lyase domain in a processive search for DNA damage. Nucleic Acids Research. PMID 28119421 DOI: 10.1093/Nar/Gkx047  0.494
2017 Perera L, Freudenthal BD, Beard WA, Pedersen LG, Wilson SH. Revealing the role of the product metal in DNA polymerase β catalysis. Nucleic Acids Research. PMID 28108654 DOI: 10.1093/Nar/Gkw1363  0.69
2017 Çağlayan M, Horton JK, Dai DP, Stefanick DF, Wilson SH. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair. Nature Communications. 8: 14045. PMID 28067232 DOI: 10.1038/Ncomms14045  0.469
2016 Perera L, Beard WA, Pedersen LG, Wilson SH. Hiding in Plain Sight: The Bimetallic Magnesium Covalent Bond in Enzyme Active Sites. Inorganic Chemistry. PMID 27976880 DOI: 10.1021/Acs.Inorgchem.6B02189  0.618
2016 Kirby TW, Gassman NR, Smith CE, Zhao ML, Horton JK, Wilson SH, London RE. DNA polymerase β contains a functional nuclear localization signal at its N-terminus. Nucleic Acids Research. PMID 27956495 DOI: 10.1093/Nar/Gkw1257  0.404
2016 Prasad R, Poltoratsky V, Hou EW, Wilson SH. Rev1 is a base excision repair enzyme with 5'-deoxyribose phosphate lyase activity. Nucleic Acids Research. PMID 27683219 DOI: 10.1093/Nar/Gkw869  0.471
2016 Sassa A, Ҫağlayan M, Rodriguez Y, Beard WA, Wilson SH, Nohmi T, Honma M, Yasui M. Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine. The Journal of Biological Chemistry. PMID 27660390 DOI: 10.1074/Jbc.M116.738732  0.561
2016 Batra VK, Beard WA, Pedersen LC, Wilson SH. Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism. Structure (London, England : 1993). PMID 27642161 DOI: 10.1016/J.Str.2016.08.006  0.536
2016 Kim T, Freudenthal BD, Beard WA, Wilson SH, Schlick T. Insertion of oxidized nucleotide triggers rapid DNA polymerase opening. Nucleic Acids Research. PMID 27034465 DOI: 10.1093/Nar/Gkw174  0.444
2016 Cilli P, Ventura I, Minoprio A, Meccia E, Martire A, Wilson SH, Bignami M, Mazzei F. Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability. Nucleic Acids Research. PMID 26980281 DOI: 10.1093/Nar/Gkw170  0.515
2016 Wallace S, Wilson S. Spotlight on DNA repair and responses to DNA damage. Dna Repair. 37: A2. PMID 26861182 DOI: 10.1016/J.Dnarep.2015.12.008  0.509
2016 Wilson SH. Coordination during the stepwise process of base lesion DNA repair Toxicology Letters. 258: S18-S19. DOI: 10.1016/J.Toxlet.2016.06.1180  0.442
2015 Çağlayan M, Wilson SH. Reprint of "Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair". Dna Repair. PMID 26596511 DOI: 10.1016/j.dnarep.2015.11.002  0.467
2015 Çağlayan M, Wilson SH. Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair. Dna Repair. 35: 85-89. PMID 26466358 DOI: 10.1016/J.Dnarep.2015.09.010  0.554
2015 Freudenthal BD, Beard WA, Cuneo MJ, Dyrkheeva NS, Wilson SH. Capturing snapshots of APE1 processing DNA damage. Nature Structural & Molecular Biology. PMID 26458045 DOI: 10.1038/Nsmb.3105  0.509
2015 Perera L, Freudenthal BD, Beard WA, Shock DD, Pedersen LG, Wilson SH. Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse. Proceedings of the National Academy of Sciences of the United States of America. 112: E5228-36. PMID 26351676 DOI: 10.1073/Pnas.1511207112  0.686
2015 Kirby TW, Gassman NR, Smith CE, Pedersen LC, Gabel SA, Sobhany M, Wilson SH, London RE. Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS. Scientific Reports. 5: 13405. PMID 26304019 DOI: 10.1038/Srep13405  0.334
2015 Fedeles BI, Freudenthal BD, Yau E, Singh V, Chang SC, Li D, Delaney JC, Wilson SH, Essigmann JM. Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer. Proceedings of the National Academy of Sciences of the United States of America. 112: E4571-80. PMID 26243878 DOI: 10.1073/Pnas.1507709112  0.313
2015 Prasad R, Dyrkheeva N, Williams J, Wilson SH. Mammalian Base Excision Repair: Functional Partnership between PARP-1 and APE1 in AP-Site Repair. Plos One. 10: e0124269. PMID 26020771 DOI: 10.1371/Journal.Pone.0124269  0.528
2015 Freudenthal BD, Beard WA, Wilson SH. New structural snapshots provide molecular insights into the mechanism of high fidelity DNA synthesis. Dna Repair. PMID 26002198 DOI: 10.1016/J.Dnarep.2015.04.007  0.509
2015 Gassman NR, Wilson SH. Micro-irradiation tools to visualize base excision repair and single-strand break repair. Dna Repair. 31: 52-63. PMID 25996408 DOI: 10.1016/J.Dnarep.2015.05.001  0.454
2015 Beard WA, Wilson SH. Structures of human DNA polymerases ν and θ expose their end game. Nature Structural & Molecular Biology. 22: 273-5. PMID 25837870 DOI: 10.1038/Nsmb.3006  0.509
2015 Gassman NR, Coskun E, Stefanick DF, Horton JK, Jaruga P, Dizdaroglu M, Wilson SH. Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. Plos One. 10: e0118819. PMID 25693136 DOI: 10.1371/Journal.Pone.0118819  0.484
2015 Ça?layan M, Horton JK, Prasad R, Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes. Nucleic Acids Research. 43: 2271-81. PMID 25662216 DOI: 10.1093/Nar/Gkv079  0.462
2015 Horton JK, Gassman NR, Dunigan BD, Stefanick DF, Wilson SH. DNA polymerase β-dependent cell survival independent of XRCC1 expression. Dna Repair. 26: 23-9. PMID 25541391 DOI: 10.1016/J.Dnarep.2014.11.008  0.471
2015 Freudenthal BD, Beard WA, Perera L, Shock DD, Kim T, Schlick T, Wilson SH. Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide. Nature. 517: 635-9. PMID 25409153 DOI: 10.1038/Nature13886  0.648
2014 Perera L, Beard WA, Pedersen LG, Wilson SH. Applications of quantum mechanical/molecular mechanical methods to the chemical insertion step of DNA and RNA polymerization. Advances in Protein Chemistry and Structural Biology. 97: 83-113. PMID 25458356 DOI: 10.1016/Bs.Apcsb.2014.10.001  0.689
2014 Beard WA, Shock DD, Batra VK, Prasad R, Wilson SH. Substrate-induced DNA polymerase β activation. The Journal of Biological Chemistry. 289: 31411-22. PMID 25261471 DOI: 10.1074/Jbc.M114.607432  0.472
2014 Bienstock RJ, Beard WA, Wilson SH. Phylogenetic analysis and evolutionary origins of DNA polymerase X-family members. Dna Repair. 22: 77-88. PMID 25112931 DOI: 10.1016/J.Dnarep.2014.07.003  0.46
2014 Hanawalt PC, Wilson SH. Coincidentally, this first issue marks the 50th anniversary of the seminal discovery of the excision-repair of damaged DNA. Preface. Dna Repair. 19: 1-2. PMID 24909491 DOI: 10.1016/J.Dnarep.2014.05.004  0.461
2014 Wilson SH. The dark side of DNA repair. Elife. 3: e03068. PMID 24844708 DOI: 10.7554/Elife.03068  0.488
2014 CaÄŸlayan M, Batra VK, Sassa A, Prasad R, Wilson SH. Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair. Nature Structural & Molecular Biology. 21: 497-9. PMID 24777061 DOI: 10.1038/Nsmb.2818  0.463
2014 Prasad R, Horton JK, Chastain PD, Gassman NR, Freudenthal BD, Hou EW, Wilson SH. Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair. Nucleic Acids Research. 42: 6337-51. PMID 24771347 DOI: 10.1093/Nar/Gku288  0.525
2014 Horton JK, Stefanick DF, Prasad R, Gassman NR, Kedar PS, Wilson SH. Base excision repair defects invoke hypersensitivity to PARP inhibition. Molecular Cancer Research : McR. 12: 1128-39. PMID 24770870 DOI: 10.1158/1541-7786.Mcr-13-0502  0.558
2014 Beard WA, Wilson SH. Structure and mechanism of DNA polymerase β. Biochemistry. 53: 2768-80. PMID 24717170 DOI: 10.1021/Bi500139H  0.55
2014 Sassa A, ÇaÄŸlayan M, Dyrkheeva NS, Beard WA, Wilson SH. Base excision repair of tandem modifications in a methylated CpG dinucleotide. The Journal of Biological Chemistry. 289: 13996-4008. PMID 24695738 DOI: 10.1074/Jbc.M114.557769  0.534
2014 Kirby TW, Derose EF, Beard WA, Shock DD, Wilson SH, London RE. Substrate rescue of DNA polymerase β containing a catastrophic L22P mutation. Biochemistry. 53: 2413-22. PMID 24655288 DOI: 10.1021/Bi5001855  0.48
2014 Oertell K, Chamberlain BT, Wu Y, Ferri E, Kashemirov BA, Beard WA, Wilson SH, McKenna CE, Goodman MF. Transition state in DNA polymerase β catalysis: rate-limiting chemistry altered by base-pair configuration. Biochemistry. 53: 1842-8. PMID 24580380 DOI: 10.1021/Bi500101Z  0.415
2014 Li Y, Freudenthal BD, Beard WA, Wilson SH, Schlick T. Optimal and variant metal-ion routes in DNA polymerase β's conformational pathways. Journal of the American Chemical Society. 136: 3630-9. PMID 24511902 DOI: 10.1021/Ja412701F  0.416
2014 Freudenthal BD, Beard WA, Wilson SH. Watching a DNA polymerase in action. Cell Cycle (Georgetown, Tex.). 13: 691-2. PMID 24424116 DOI: 10.4161/Cc.27789  0.549
2014 Wu S, Beard WA, Pedersen LG, Wilson SH. Structural comparison of DNA polymerase architecture suggests a nucleotide gateway to the polymerase active site. Chemical Reviews. 114: 2759-74. PMID 24359247 DOI: 10.1021/Cr3005179  0.669
2013 Horton JK, Wilson SH. Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity. Frontiers in Oncology. 3: 257. PMID 24137565 DOI: 10.3389/Fonc.2013.00257  0.533
2013 Chary P, Beard WA, Wilson SH, Lloyd RS. Inhibition of HIV-1 reverse transcriptase-catalyzed synthesis by intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide adducts. Plos One. 8: e72131. PMID 24069141 DOI: 10.1371/Journal.Pone.0072131  0.471
2013 Sassa A, Beard WA, Shock DD, Wilson SH. Steady-state, pre-steady-state, and single-turnover kinetic measurement for DNA glycosylase activity Journal of Visualized Experiments : Jove. PMID 23995844 DOI: 10.3791/50695  0.39
2013 An C, Beard WA, Chen D, Wilson SH, Makridakis NM. Understanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer. International Journal of Oncology. 43: 1131-40. PMID 23877444 DOI: 10.3892/Ijo.2013.2022  0.355
2013 Horton JK, Stefanick DF, Gassman NR, Williams JG, Gabel SA, Cuneo MJ, Prasad R, Kedar PS, Derose EF, Hou EW, London RE, Wilson SH. Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. Dna Repair. 12: 774-85. PMID 23871146 DOI: 10.1016/J.Dnarep.2013.06.004  0.424
2013 Freudenthal BD, Beard WA, Shock DD, Wilson SH. Observing a DNA polymerase choose right from wrong. Cell. 154: 157-68. PMID 23827680 DOI: 10.1016/J.Cell.2013.05.048  0.517
2013 Masaoka A, Gassman NR, Horton JK, Kedar PS, Witt KL, Hobbs CA, Kissling GE, Tano K, Asagoshi K, Wilson SH. Interaction between DNA Polymerase β and BRCA1. Plos One. 8: e66801. PMID 23826138 DOI: 10.1371/Journal.Pone.0066801  0.475
2013 Vaidyanathan VG, Liang F, Beard WA, Shock DD, Wilson SH, Cho BP. Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site. The Journal of Biological Chemistry. 288: 23573-85. PMID 23798703 DOI: 10.1074/Jbc.M113.476150  0.506
2013 Batra VK, Perera L, Lin P, Shock DD, Beard WA, Pedersen LC, Pedersen LG, Wilson SH. Amino acid substitution in the active site of DNA polymerase β explains the energy barrier of the nucleotidyl transfer reaction. Journal of the American Chemical Society. 135: 8078-88. PMID 23647366 DOI: 10.1021/Ja403842J  0.713
2013 Freudenthal BD, Beard WA, Wilson SH. DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion. Nucleic Acids Research. 41: 1848-58. PMID 23267011 DOI: 10.1093/Nar/Gks1276  0.499
2013 Horton JK, Wilson SH. Predicting enhanced cell killing through PARP inhibition. Molecular Cancer Research : McR. 11: 13-8. PMID 23193155 DOI: 10.1158/1541-7786.Mcr-12-0512  0.516
2013 Rajan R, Prasad R, Taneja B, Wilson SH, Mondragón A. Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies. Nucleic Acids Research. 41: 657-66. PMID 23125368 DOI: 10.1093/Nar/Gks1017  0.414
2013 Van Houten B, Wilson SH, Motter K. Announcement: New special Database issue feature for DNA Repair Dna Repair. 12: 458. DOI: 10.1016/J.Dnarep.2013.04.025  0.452
2012 Schlick T, Arora K, Beard WA, Wilson SH. Perspective: pre-chemistry conformational changes in DNA polymerase mechanisms. Theoretical Chemistry Accounts. 131: 1287. PMID 23459563 DOI: 10.1007/S00214-012-1287-7  0.489
2012 Gassman NR, Stefanick DF, Kedar PS, Horton JK, Wilson SH. Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts. Plos One. 7: e49301. PMID 23145148 DOI: 10.1371/Journal.Pone.0049301  0.53
2012 Heacock M, Poltoratsky V, Prasad R, Wilson SH. Evidence for Abasic Site Sugar Phosphate-Mediated Cytotoxicity in Alkylating Agent Treated Saccharomyces cerevisiae Plos One. 7. PMID 23144716 DOI: 10.1371/Journal.Pone.0047945  0.449
2012 Chary P, Beard WA, Wilson SH, Lloyd RS. DNA polymerase β gap-filling translesion DNA synthesis. Chemical Research in Toxicology. 25: 2744-54. PMID 23121263 DOI: 10.1021/Tx300368F  0.536
2012 Oertell K, Wu Y, Zakharova VM, Kashemirov BA, Shock DD, Beard WA, Wilson SH, McKenna CE, Goodman MF. Effect of β,γ-CHF- and β,γ-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase β. Biochemistry. 51: 8491-501. PMID 23043620 DOI: 10.1021/Bi3010335  0.321
2012 Prasad R, Williams JG, Hou EW, Wilson SH. Pol β associated complex and base excision repair factors in mouse fibroblasts. Nucleic Acids Research. 40: 11571-82. PMID 23042675 DOI: 10.1093/Nar/Gks898  0.501
2012 Sassa A, Beard WA, Prasad R, Wilson SH. DNA sequence context effects on the glycosylase activity of human 8-oxoguanine DNA glycosylase. The Journal of Biological Chemistry. 287: 36702-10. PMID 22989888 DOI: 10.1074/Jbc.M112.397786  0.503
2012 Freudenthal BD, Beard WA, Wilson SH. Structures of dNTP intermediate states during DNA polymerase active site assembly. Structure (London, England : 1993). 20: 1829-37. PMID 22959623 DOI: 10.1016/J.Str.2012.08.008  0.504
2012 Masaoka A, Gassman NR, Kedar PS, Prasad R, Hou EW, Horton JK, Bustin M, Wilson SH. HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts. The Journal of Biological Chemistry. 287: 27648-58. PMID 22736760 DOI: 10.1074/Jbc.M112.370759  0.494
2012 Wu Y, Zakharova VM, Kashemirov BA, Goodman MF, Batra VK, Wilson SH, McKenna CE. β,γ-CHF- and β,γ-CHCl-dGTP diastereomers: synthesis, discrete 31P NMR signatures, and absolute configurations of new stereochemical probes for DNA polymerases. Journal of the American Chemical Society. 134: 8734-7. PMID 22397499 DOI: 10.1021/Ja300218X  0.322
2012 Chamberlain BT, Batra VK, Beard WA, Kadina AP, Shock DD, Kashemirov BA, McKenna CE, Goodman MF, Wilson SH. Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β. Chembiochem : a European Journal of Chemical Biology. 13: 528-30. PMID 22315190 DOI: 10.1002/Cbic.201100738  0.412
2012 Liu Y, Wilson SH. DNA base excision repair: A mechanism of trinucleotide repeat expansion Trends in Biochemical Sciences. 37: 162-172. PMID 22285516 DOI: 10.1016/J.Tibs.2011.12.002  0.542
2012 Kedar PS, Stefanick DF, Horton JK, Wilson SH. Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts. Molecular Cancer Research : McR. 10: 360-8. PMID 22246237 DOI: 10.1158/1541-7786.Mcr-11-0477  0.513
2012 Batra VK, Shock DD, Beard WA, McKenna CE, Wilson SH. Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion. Proceedings of the National Academy of Sciences of the United States of America. 109: 113-8. PMID 22178760 DOI: 10.1073/Pnas.1112235108  0.516
2012 Kirby TW, DeRose EF, Cavanaugh NA, Beard WA, Shock DD, Mueller GA, Wilson SH, London RE. Metal-induced DNA translocation leads to DNA polymerase conformational activation. Nucleic Acids Research. 40: 2974-83. PMID 22169953 DOI: 10.1093/Nar/Gkr1218  0.522
2012 Asagoshi K, Lehmann W, Braithwaite EK, Santana-Santos L, Prasad R, Freedman JH, Van Houten B, Wilson SH. Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β. Nucleic Acids Research. 40: 670-81. PMID 21917855 DOI: 10.1093/nar/gkr727  0.429
2012 Wu Y, Zakharova VM, Kashemirov BA, Goodman MF, Batra VK, Wilson SH, McKenna CE. Beta,gamma-CHF- and beta,gamma-CHCl-dGTP Diastereomers: Synthesis, Discrete (31)P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases Journal of the American Chemical Society. 134: 8734-8737. DOI: 10.2210/Pdb4Do9/Pdb  0.385
2012 Chamberlain BT, Batra VK, Beard WA, Kadina AP, Shock DD, Kashemirov BA, McKenna CE, Goodman MF, Wilson SH. Stereospecific Formation of a Ternary Complex of (S)-alpha, beta-Fluoromethylene-dATP with DNA Pol beta. Chembiochem. 13: 528-530. DOI: 10.2210/Pdb3Tfr/Pdb  0.381
2011 Naidu MD, Agarwal R, Pena LA, Cunha L, Mezei M, Shen M, Wilson DM, Liu Y, Sanchez Z, Chaudhary P, Wilson SH, Waring MJ. Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. Plos One. 6: e23679. PMID 21935361 DOI: 10.1371/Journal.Pone.0023679  0.445
2011 Cavanaugh NA, Beard WA, Batra VK, Perera L, Pedersen LG, Wilson SH. Molecular insights into DNA polymerase deterrents for ribonucleotide insertion. The Journal of Biological Chemistry. 286: 31650-60. PMID 21733843 DOI: 10.1074/Jbc.M111.253401  0.726
2011 Horton JK, Stefanick DF, Zeng JY, Carrozza MJ, Wilson SH. Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition. Dna Repair. 10: 225-34. PMID 21130714 DOI: 10.1016/J.Dnarep.2010.11.003  0.34
2011 Prasad R, Beard WA, Batra VK, Liu Y, Shock DD, Wilson SH. A review of recent experiments on step-to-step “hand-off” of the DNA intermediates in mammalian base excision repair pathways Molecular Biology. 45: 536-550. DOI: 10.1134/S0026893311040091  0.53
2011 Asagoshi K, Wilson SH. Base-excision repair: Role of DNA polymerase β in late-stage base excision repair Current Cancer Research. 6: 297-319. DOI: 10.1007/978-1-61737-995-6_14  0.36
2010 Khodyreva SN, Prasad R, Ilina ES, Sukhanova MV, Kutuzov MM, Liu Y, Hou EW, Wilson SH, Lavrik OI. Apurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1). Proceedings of the National Academy of Sciences of the United States of America. 107: 22090-5. PMID 21127267 DOI: 10.1073/Pnas.1009182107  0.49
2010 Prasad R, Shock DD, Beard WA, Wilson SH. Substrate channeling in mammalian base excision repair pathways: passing the baton. The Journal of Biological Chemistry. 285: 40479-88. PMID 20952393 DOI: 10.1074/Jbc.M110.155267  0.499
2010 Wilson SH, Beard WA, Shock DD, Batra VK, Cavanaugh NA, Prasad R, Hou EW, Liu Y, Asagoshi K, Horton JK, Stefanick DF, Kedar PS, Carrozza MJ, Masaoka A, Heacock ML. Base excision repair and design of small molecule inhibitors of human DNA polymerase β. Cellular and Molecular Life Sciences : Cmls. 67: 3633-47. PMID 20844920 DOI: 10.1007/S00018-010-0489-1  0.424
2010 Poltoratsky V, Heacock M, Kissling GE, Prasad R, Wilson SH. Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break Molecular Immunology. 48: 164-170. PMID 20828826 DOI: 10.1016/J.Molimm.2010.08.013  0.443
2010 Braithwaite EK, Kedar PS, Stumpo DJ, Bertocci B, Freedman JH, Samson LD, Wilson SH. DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts. Plos One. 5: e12229. PMID 20805875 DOI: 10.1371/Journal.Pone.0012229  0.552
2010 Surya Prakash GK, Zibinsky M, Upton TG, Kashemirov BA, McKenna CE, Oertell K, Goodman MF, Batra VK, Pedersen LC, Beard WA, Shock DD, Wilson SH, Olah GA. Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Proceedings of the National Academy of Sciences of the United States of America. 107: 15693-8. PMID 20724659 DOI: 10.1073/Pnas.1007430107  0.431
2010 Beard WA, Batra VK, Wilson SH. DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 703: 18-23. PMID 20696268 DOI: 10.1016/J.Mrgentox.2010.07.013  0.516
2010 Heacock ML, Stefanick DF, Horton JK, Wilson SH. Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks. Dna Repair. 9: 929-36. PMID 20573551 DOI: 10.1016/J.Dnarep.2010.05.007  0.473
2010 Batra VK, Beard WA, Hou EW, Pedersen LC, Prasad R, Wilson SH. Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Nature Structural & Molecular Biology. 17: 889-90. PMID 20526335 DOI: 10.1038/Nsmb.1852  0.526
2010 Cavanaugh NA, Beard WA, Wilson SH. DNA polymerase beta ribonucleotide discrimination: insertion, misinsertion, extension, and coding. The Journal of Biological Chemistry. 285: 24457-65. PMID 20519499 DOI: 10.1074/Jbc.M110.132407  0.551
2010 Batra VK, Pedersen LC, Beard WA, Wilson SH, Kashemirov BA, Upton TG, Goodman MF, McKenna CE. Halogenated beta,gamma-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase beta: structural evidence for stereospecific binding of the fluoromethylene analogues. Journal of the American Chemical Society. 132: 7617-25. PMID 20465217 DOI: 10.1021/Ja909370K  0.426
2010 Asagoshi K, Tano K, Chastain PD, Adachi N, Sonoda E, Kikuchi K, Koyama H, Nagata K, Kaufman DG, Takeda S, Wilson SH, Watanabe M, Swenberg JA, Nakamura J. FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells. Molecular Cancer Research : McR. 8: 204-15. PMID 20145043 DOI: 10.1158/1541-7786.Mcr-09-0253  0.326
2010 Liu Y, Prasad R, Wilson SH. HMGB1: Roles in base excision repair and related function Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms. 1799: 119-130. PMID 20123074 DOI: 10.1016/J.Bbagrm.2009.11.008  0.448
2010 Asagoshi K, Liu Y, Masaoka A, Lan L, Prasad R, Horton JK, Brown AR, Wang XH, Bdour HM, Sobol RW, Taylor JS, Yasui A, Wilson SH. DNA polymerase beta-dependent long patch base excision repair in living cells. Dna Repair. 9: 109-19. PMID 20006562 DOI: 10.1016/J.Dnarep.2009.11.002  0.392
2009 Beard WA, Shock DD, Batra VK, Pedersen LC, Wilson SH. DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". The Journal of Biological Chemistry. 284: 31680-9. PMID 19759017 DOI: 10.1074/Jbc.M109.029843  0.515
2009 Masaoka A, Horton JK, Beard WA, Wilson SH. DNA polymerase beta and PARP activities in base excision repair in living cells. Dna Repair. 8: 1290-9. PMID 19748837 DOI: 10.1016/J.Dnarep.2009.08.004  0.505
2009 Carrozza MJ, Stefanick DF, Horton JK, Kedar PS, Wilson SH. PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM. Dna Repair. 8: 1264-72. PMID 19717351 DOI: 10.1016/J.Dnarep.2009.07.010  0.416
2009 Dorjsuren D, Wilson DM, Beard WA, McDonald JP, Austin CP, Woodgate R, Wilson SH, Simeonov A. A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic Acids Research. 37: e128. PMID 19684079 DOI: 10.1093/Nar/Gkp641  0.535
2009 Liu Y, Prasad R, Beard WA, Hou EW, Horton JK, McMurray CT, Wilson SH. Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion. The Journal of Biological Chemistry. 284: 28352-66. PMID 19674974 DOI: 10.1074/Jbc.M109.050286  0.45
2009 Yoshizawa K, Jelezcova E, Brown AR, Foley JF, Nyska A, Cui X, Hofseth LJ, Maronpot RM, Wilson SH, Sepulveda AR, Sobol RW. Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. Plos One. 4: e6493. PMID 19654874 DOI: 10.1371/Journal.Pone.0006493  0.338
2009 Simonelli V, D’Errico M, Palli D, Prasad R, Wilson SH, Dogliotti E. Characterization of DNA polymerase β splicing variants in gastric cancer: the most frequent exon 2-deleted isoform is a non coding RNA Mutation Research. 670: 79-87. PMID 19635489 DOI: 10.1016/J.Mrfmmm.2009.07.007  0.401
2009 Upton TG, Kashemirov BA, McKenna CE, Goodman MF, Prakash GK, Kultyshev R, Batra VK, Shock DD, Pedersen LC, Beard WA, Wilson SH. Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. Organic Letters. 11: 1883-6. PMID 19351147 DOI: 10.1021/Ol701755K  0.331
2009 Prasad R, Longley MJ, Sharief FS, Hou EW, Copeland WC, Wilson SH. Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Nucleic Acids Research. 37: 1868-77. PMID 19188258 DOI: 10.1093/Nar/Gkp035  0.551
2008 Liang F, Jain N, Hutchens T, Shock DD, Beard WA, Wilson SH, Chiarelli MP, Cho BP. Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT. Journal of Medicinal Chemistry. 51: 6460-70. PMID 18811136 DOI: 10.1021/Jm800692A  0.355
2008 Kedar PS, Stefanick DF, Horton JK, Wilson SH. Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition. Dna Repair. 7: 1787-98. PMID 18691676 DOI: 10.1016/J.Dnarep.2008.07.006  0.364
2008 Allen D, Herbert DC, McMahan CA, Rotrekl V, Sobol RW, Wilson SH, Walter CA. Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice. Biology of Reproduction. 79: 824-31. PMID 18650495 DOI: 10.1095/Biolreprod.108.069104  0.457
2008 Batra VK, Beard WA, Shock DD, Pedersen LC, Wilson SH. Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Molecular Cell. 30: 315-24. PMID 18471977 DOI: 10.1016/J.Molcel.2008.02.025  0.493
2008 Poltoratsky V, Horton JK, Prasad R, Beard WA, Woodgate R, Wilson SH. Negligible impact of pol iota expression on the alkylation sensitivity of pol beta-deficient mouse fibroblast cells. Dna Repair. 7: 830-3. PMID 18434259 DOI: 10.1016/J.Dnarep.2008.02.013  0.495
2008 Oka H, Sakai W, Sonoda E, Nakamura J, Asagoshi K, Wilson SH, Kobayashi M, Yamamoto K, Heierhorst J, Takeda S, Taniguchi Y. DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion. Biochemical and Biophysical Research Communications. 371: 225-9. PMID 18433721 DOI: 10.1016/J.Bbrc.2008.04.052  0.448
2008 Lin P, Batra VK, Pedersen LC, Beard WA, Wilson SH, Pedersen LG. Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta. Proceedings of the National Academy of Sciences of the United States of America. 105: 5670-4. PMID 18391201 DOI: 10.1073/Pnas.0801257105  0.607
2008 Horton JK, Watson M, Stefanick DF, Shaughnessy DT, Taylor JA, Wilson SH. XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Cell Research. 18: 48-63. PMID 18166976 DOI: 10.1038/Cr.2008.7  0.534
2008 Sucato CA, Upton TG, Kashemirov BA, Osuna J, Oertell K, Beard WA, Wilson SH, Florián J, Warshel A, McKenna CE, Goodman MF. DNA polymerase beta fidelity: halomethylene-modified leaving groups in pre-steady-state kinetic analysis reveal differences at the chemical transition state. Biochemistry. 47: 870-9. PMID 18161950 DOI: 10.1021/Bi7014162  0.449
2008 Xiang Y, Goodman MF, Beard WA, Wilson SH, Warshel A. Exploring the role of large conformational changes in the fidelity of DNA polymerase beta. Proteins. 70: 231-47. PMID 17671961 DOI: 10.1002/Prot.21668  0.337
2007 McKenna CE, Kashemirov BA, Upton TG, Batra VK, Goodman MF, Pedersen LC, Beard WA, Wilson SH. (R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. Journal of the American Chemical Society. 129: 15412-3. PMID 18031037 DOI: 10.1021/Ja072127V  0.502
2007 Prasad R, Liu Y, Deterding LJ, Poltoratsky VP, Kedar PS, Horton JK, Kanno S, Asagoshi K, Hou EW, Khodyreva SN, Lavrik OI, Tomer KB, Yasui A, Wilson SH. HMGB1 is a cofactor in mammalian base excision repair. Molecular Cell. 27: 829-41. PMID 17803946 DOI: 10.1016/J.Molcel.2007.06.029  0.496
2007 Hou EW, Prasad R, Asagoshi K, Masaoka A, Wilson SH. Comparative assessment of plasmid and oligonucleotide DNA substrates in measurement of in vitro base excision repair activity. Nucleic Acids Research. 35: e112. PMID 17720705 DOI: 10.1093/Nar/Gkm639  0.507
2007 Friedberg EC, Hanaoka F, Tanaka K, Wilson S, Yasui A. The 3rd Japan-US DNA Repair Meeting, Sendai, Japan, May 7-11, 2007. Dna Repair. 6: 1545-55. PMID 17704011 DOI: 10.1016/J.Dnarep.2007.07.001  0.511
2007 Das S, Chattopadhyay R, Bhakat KK, Boldogh I, Kohno K, Prasad R, Wilson SH, Hazra TK. Stimulation of NEIL2-mediated Oxidized Base Excision Repair via YB-1 Interaction during Oxidative Stress Journal of Biological Chemistry. 282: 28474-28484. PMID 17686777 DOI: 10.1074/Jbc.M704672200  0.46
2007 Moon AF, Garcia-Diaz M, Batra VK, Beard WA, Bebenek K, Kunkel TA, Wilson SH, Pedersen LC. The X family portrait: structural insights into biological functions of X family polymerases. Dna Repair. 6: 1709-25. PMID 17631059 DOI: 10.1016/J.Dnarep.2007.05.009  0.462
2007 Nakanishi S, Prasad R, Wilson SH, Smerdon M. Different structural states in oligonucleosomes are required for early versus late steps of base excision repair. Nucleic Acids Research. 35: 4313-21. PMID 17576692 DOI: 10.1093/Nar/Gkm436  0.544
2007 Kovtun IV, Liu Y, Bjoras M, Klungland A, Wilson SH, McMurray CT. OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells Nature. 447: 447-452. PMID 17450122 DOI: 10.1038/Nature05778  0.4
2007 Tano K, Nakamura J, Asagoshi K, Arakawa H, Sonoda E, Braithwaite EK, Prasad R, Buerstedde JM, Takeda S, Watanabe M, Wilson SH. Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells. Dna Repair. 6: 869-75. PMID 17363341 DOI: 10.1016/J.Dnarep.2007.01.011  0.502
2007 Liu Y, Prasad R, Beard WA, Kedar PS, Hou EW, Shock DD, Wilson SH. Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta. The Journal of Biological Chemistry. 282: 13532-41. PMID 17355977 DOI: 10.1074/Jbc.M611295200  0.541
2007 Wang Y, Reddy S, Beard WA, Wilson SH, Schlick T. Differing conformational pathways before and after chemistry for insertion of dATP versus dCTP opposite 8-oxoG in DNA polymerase beta. Biophysical Journal. 92: 3063-70. PMID 17293403 DOI: 10.1529/Biophysj.106.092106  0.412
2007 Sucato CA, Upton TG, Kashemirov BA, Batra VK, Martínek V, Xiang Y, Beard WA, Pedersen LC, Wilson SH, McKenna CE, Florián J, Warshel A, Goodman MF. Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta. Biochemistry. 46: 461-71. PMID 17209556 DOI: 10.1021/Bi061517B  0.444
2007 Oelschlaeger P, Klahn M, Beard WA, Wilson SH, Warshel A. Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: improved accuracy in studies of structural features and mutational effects. Journal of Molecular Biology. 366: 687-701. PMID 17174326 DOI: 10.1016/J.Jmb.2006.10.095  0.503
2007 Poltoratsky V, Prasad R, Horton JK, Wilson SH. Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines. Dna Repair. 6: 244-53. PMID 17127106 DOI: 10.1016/J.Dnarep.2006.10.003  0.448
2007 Horton JK, Wilson SH. Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency Dna Repair. 6: 530-543. PMID 17113833 DOI: 10.1016/J.Dnarep.2006.10.016  0.462
2007 Wilson SH. W. Siede, W. Kow and P. Doetsch, Editors, DNA Damage Recognition, Taylor & Francis Group, New York (2006) ISBN 10-0-8247-5961-3; 13:978-0-8247-5961-2. Dna Repair. 6: 396-396. DOI: 10.1016/J.Dnarep.2006.12.004  0.358
2006 Radhakrishnan R, Arora K, Wang Y, Beard WA, Wilson SH, Schlick T. Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection. Biochemistry. 45: 15142-56. PMID 17176036 DOI: 10.1021/Bi061353Z  0.491
2006 Batra VK, Shock DD, Prasad R, Beard WA, Hou EW, Pedersen LC, Sayer JM, Yagi H, Kumar S, Jerina DM, Wilson SH. Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Proceedings of the National Academy of Sciences of the United States of America. 103: 17231-6. PMID 17079493 DOI: 10.1073/Pnas.0605069103  0.544
2006 Yoshimura M, Kohzaki M, Nakamura J, Asagoshi K, Sonoda E, Hou E, Prasad R, Wilson SH, Tano K, Yasui A, Lan L, Seki M, Wood RD, Arakawa H, Buerstedde JM, et al. Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage. Molecular Cell. 24: 115-25. PMID 17018297 DOI: 10.1016/J.Molcel.2006.07.032  0.467
2006 Das A, Wiederhold L, Leppard JB, Kedar P, Prasad R, Wang H, Boldogh I, Karimi-Busheri F, Weinfeld M, Tomkinson AE, Wilson SH, Mitra S, Hazra TK. NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. Dna Repair. 5: 1439-48. PMID 16982218 DOI: 10.1016/J.Dnarep.2006.07.003  0.546
2006 Lin P, Pedersen LC, Batra VK, Beard WA, Wilson SH, Pedersen LG. Energy analysis of chemistry for correct insertion by DNA polymerase beta. Proceedings of the National Academy of Sciences of the United States of America. 103: 13294-9. PMID 16938895 DOI: 10.1073/Pnas.0606006103  0.611
2006 Cabelof DC, Ikeno Y, Nyska A, Busuttil RA, Anyangwe N, Vijg J, Matherly LH, Tucker JD, Wilson SH, Richardson A, Heydari AR. Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate. Cancer Research. 66: 7460-5. PMID 16885342 DOI: 10.1158/0008-5472.Can-06-1177  0.32
2006 Beard WA, Prasad R, Wilson SH. Activities and Mechanism of DNA Polymerase β Methods in Enzymology. 408: 91-107. PMID 16793365 DOI: 10.1016/S0076-6879(06)08007-4  0.558
2006 Gao G, Prasad R, Lodwig SN, Unkefer CJ, Beard WA, Wilson SH, London RE. Determination of lysine pK values using [5-13C]lysine: application to the lyase domain of DNA Pol beta. Journal of the American Chemical Society. 128: 8104-5. PMID 16787052 DOI: 10.1021/Ja061473U  0.376
2006 Batra VK, Beard WA, Shock DD, Krahn JM, Pedersen LC, Wilson SH. Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure (London, England : 1993). 14: 757-66. PMID 16615916 DOI: 10.1016/J.Str.2006.01.011  0.461
2006 Beard WA, Wilson SH. Structure and mechanism of DNA polymerase β Chemical Reviews. 106: 361-382. PMID 16464010 DOI: 10.1021/cr0404904  0.329
2006 Harrigan JA, Wilson DM, Prasad R, Opresko PL, Beck G, May A, Wilson SH, Bohr VA. The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Nucleic Acids Research. 34: 745-54. PMID 16449207 DOI: 10.1093/Nar/Gkj475  0.513
2006 Liu Y, Prasad R, Wilson SH. DNA repair models for understanding triplet repeat instability Genetic Instabilities and Neurological Diseases, Second Edition. 667-678. DOI: 10.1016/B978-012369462-1/50043-0  0.437
2006 Beard WA, Wilson SH. Structure and Mechanism of DNA Polymerase β Cheminform. 37. DOI: 10.1002/chin.200621260  0.38
2005 Kirby TW, DeRose EF, Beard WA, Wilson SH, London RE. A thymine isostere in the templating position disrupts assembly of the closed DNA polymerase beta ternary complex. Biochemistry. 44: 15230-7. PMID 16285726 DOI: 10.1021/Bi0511742  0.515
2005 Beard WA, Wilson SH. Syn-full behavior by T7 DNA polymerase Structure. 13: 1580-1582. PMID 16271879 DOI: 10.1016/J.Str.2005.10.003  0.451
2005 Arora K, Beard WA, Wilson SH, Schlick T. Mismatch-induced conformational distortions in polymerase beta support an induced-fit mechanism for fidelity. Biochemistry. 44: 13328-41. PMID 16201758 DOI: 10.1021/Bi0507682  0.446
2005 Prasad R, Batra VK, Yang XP, Krahn JM, Pedersen LC, Beard WA, Wilson SH. Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism. Dna Repair. 4: 1347-57. PMID 16172026 DOI: 10.1016/J.Dnarep.2005.08.009  0.502
2005 Batra VK, Beard WA, Shock DD, Pedersen LC, Wilson SH. Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Structure (London, England : 1993). 13: 1225-33. PMID 16084394 DOI: 10.1016/J.Str.2005.05.010  0.552
2005 Braithwaite EK, Kedar PS, Lan L, Polosina YY, Asagoshi K, Poltoratsky VP, Horton JK, Miller H, Teebor GW, Yasui A, Wilson SH. DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair. The Journal of Biological Chemistry. 280: 31641-7. PMID 16002405 DOI: 10.1074/jbc.C500256200  0.432
2005 Horton JK, Stefanick DF, Wilson SH. Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death Dna Repair. 4: 1111-1120. PMID 16002346 DOI: 10.1016/J.Dnarep.2005.05.011  0.398
2005 Poltoratsky V, Horton JK, Prasad R, Wilson SH. REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast. Dna Repair. 4: 1182-8. PMID 15950550 DOI: 10.1016/J.Dnarep.2005.05.002  0.396
2005 Braithwaite EK, Prasad R, Shock DD, Hou EW, Beard WA, Wilson SH. DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts. The Journal of Biological Chemistry. 280: 18469-75. PMID 15749700 DOI: 10.1074/Jbc.M411864200  0.467
2005 Sukhanova MV, Khodyreva SN, Lebedeva NA, Prasad R, Wilson SH, Lavrik OI. Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase β and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity Nucleic Acids Research. 33: 1222-1229. PMID 15731342 DOI: 10.1093/Nar/Gki266  0.522
2005 Horton JK, Stefanick DF, Naron JM, Kedar PS, Wilson SH. Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure. The Journal of Biological Chemistry. 280: 15773-85. PMID 15701627 DOI: 10.1074/Jbc.M413841200  0.481
2005 Beard BC, Stevenson JJ, Wilson SH, Smerdon MJ. Base excision repair in nucleosomes lacking histone tails. Dna Repair. 4: 203-9. PMID 15590328 DOI: 10.1016/J.Dnarep.2004.09.011  0.473
2005 Liu Y, Beard WA, Shock DD, Prasad R, Hou EW, Wilson SH. DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair. The Journal of Biological Chemistry. 280: 3665-74. PMID 15561706 DOI: 10.1074/Jbc.M412922200  0.531
2005 Gryk M, Marintchev A, Maciejewski M, Robertson A, Mullen M, Wilson S, Mullen G. 1H, 13C and 15N resonance assignments for the perdeuterated 22 kD palm-thumb domain of DNA polymerase B in complex with the XRCC1 N-terminal domain Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr5209  0.339
2004 Krahn JM, Beard WA, Wilson SH. Structural insights into DNA polymerase β deterrents for misincorporation support an induced-fit mechanism for fidelity Structure. 12: 1823-1832. PMID 15458631 DOI: 10.1016/J.Str.2004.08.001  0.514
2004 Lan L, Nakajima S, Oohata Y, Takao M, Okano S, Masutani M, Wilson SH, Yasui A. In situ analysis of repair processes for oxidative DNA damage in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 13738-43. PMID 15365186 DOI: 10.1073/Pnas.0406048101  0.505
2004 Wiederhold L, Leppard JB, Kedar P, Karimi-Busheri F, Rasouli-Nia A, Weinfeld M, Tomkinson AE, Izumi T, Prasad R, Wilson SH, Mitra S, Hazra TK. AP endonuclease-independent DNA base excision repair in human cells. Molecular Cell. 15: 209-20. PMID 15260972 DOI: 10.1016/J.Molcel.2004.06.003  0.543
2004 Hu HY, Horton JK, Gryk MR, Prasad R, Naron JM, Sun DA, Hecht SM, Wilson SH, Mullen GP. Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping. The Journal of Biological Chemistry. 279: 39736-44. PMID 15258144 DOI: 10.1074/Jbc.M402842200  0.482
2004 Bose-Basu B, DeRose EF, Kirby TW, Mueller GA, Beard WA, Wilson SH, London RE. Dynamic characterization of a DNA repair enzyme: NMR studies of [methyl-13C]methionine-labeled DNA polymerase beta. Biochemistry. 43: 8911-22. PMID 15248749 DOI: 10.1021/Bi049641N  0.507
2004 Yang L, Arora K, Beard WA, Wilson SH, Schlick T. Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly. Journal of the American Chemical Society. 126: 8441-53. PMID 15238001 DOI: 10.1021/Ja049412O  0.418
2004 Endres M, Biniszkiewicz D, Sobol RW, Harms C, Ahmadi M, Lipski A, Katchanov J, Mergenthaler P, Dirnagl U, Wilson SH, Meisel A, Jaenisch R. Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. The Journal of Clinical Investigation. 113: 1711-21. PMID 15199406 DOI: 10.1172/Jci20926  0.364
2004 Yang L, Beard WA, Wilson SH, Broyde S, Schlick T. Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses. Biophysical Journal. 86: 3392-408. PMID 15189842 DOI: 10.1529/Biophysj.103.036012  0.429
2004 Bohr VA, Souza-Pinto N, Wilson S. First US-EU DNA repair meeting: endogenous stress, National Conference Center, VA, USA, 14-18 October 2003. Dna Repair. 3: 543-559. PMID 15162818 DOI: 10.1016/J.Dnarep.2004.01.008  0.44
2004 Beard WA, Shock DD, Wilson SH. Influence of DNA structure on DNA polymerase β active site function. Extension of mutagenic DNA intermediates Journal of Biological Chemistry. 279: 31921-31929. PMID 15145936 DOI: 10.1074/Jbc.M404016200  0.559
2004 Cistulli C, Lavrik OI, Prasad R, Hou E, Wilson SH. AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate. Dna Repair. 3: 581-91. PMID 15135726 DOI: 10.1016/J.Dnarep.2003.09.012  0.46
2004 Poltoratsky VP, Wilson SH, Kunkel TA, Pavlov YI. Recombinogenic phenotype of human activation-induced cytosine deaminase. Journal of Immunology (Baltimore, Md. : 1950). 172: 4308-13. PMID 15034045 DOI: 10.4049/Jimmunol.172.7.4308  0.495
2004 Hou EW, Prasad R, Beard WA, Wilson SH. High-level expression and purification of untagged and histidine-tagged HIV-1 reverse transcriptase. Protein Expression and Purification. 34: 75-86. PMID 14766302 DOI: 10.1016/J.Pep.2003.10.018  0.326
2004 Friedberg EC, Hanaoka F, Tanaka K, Yasui A, Wilson SH. The 2nd US–Japan DNA Repair Meeting, Honolulu, Hawaii, June 4–8, 2004 Dna Repair. 3: 1661-1674. DOI: 10.1016/J.Dnarep.2004.07.005  0.377
2003 Cabelof DC, Guo Z, Raffoul JJ, Sobol RW, Wilson SH, Richardson A, Heydari AR. Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens. Cancer Research. 63: 5799-807. PMID 14522902  0.364
2003 Chyan YJ, Rawson TY, Wilson SH. Cloning and characterization of a novel member of the human ATF/CREB family: ATF2 deletion, a potential regulator of the human DNA polymerase β promoter Gene. 312: 117-124. PMID 12909347 DOI: 10.1016/S0378-1119(03)00607-3  0.3
2003 Sobol RW, Kartalou M, Almeida KH, Joyce DF, Engelward BP, Horton JK, Prasad R, Samson LD, Wilson SH. Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. The Journal of Biological Chemistry. 278: 39951-9. PMID 12882965 DOI: 10.1074/Jbc.M306592200  0.508
2003 Beard BC, Wilson SH, Smerdon MJ. Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomes. Proceedings of the National Academy of Sciences of the United States of America. 100: 7465-70. PMID 12799467 DOI: 10.1073/Pnas.1330328100  0.534
2003 Prasad R, Bebenek K, Hou E, Shock DD, Beard WA, Woodgate R, Kunkel TA, Wilson SH. Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis. The Journal of Biological Chemistry. 278: 29649-54. PMID 12777390 DOI: 10.1074/Jbc.M305399200  0.554
2003 Beard WA, Wilson SH. Structural insights into the origins of DNA polymerase fidelity Structure. 11: 489-496. PMID 12737815 DOI: 10.1016/S0969-2126(03)00051-0  0.545
2003 Matsuda T, Vande Berg BJ, Bebenek K, Osheroff WP, Wilson SH, Kunkel TA. The base substitution fidelity of DNA polymerase beta-dependent single nucleotide base excision repair. The Journal of Biological Chemistry. 278: 25947-51. PMID 12734201 DOI: 10.1074/Jbc.C300170200  0.553
2003 Friedberg EC, Hanaoka F, Tanaka K, Wilson SH, Yasui A, Sugasawa K, Matsunaga T, Madura K, Sweder K, Van Houten B, Cooper P, Shiomi T, Grollman A, Nakabeppu Y, Wallace S, et al. Report on the First US-Japan DNA Repair Meeting Sendai, Japan, October 27-31, 2002 Dna Repair. 2: 639-652. PMID 12713820 DOI: 10.1016/S1568-7864(03)00038-7  0.499
2003 Sobol RW, Foley JF, Nyska A, Davidson MG, Wilson SH. Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice. Dna Repair. 2: 609-22. PMID 12713817 DOI: 10.1016/S1568-7864(03)00026-0  0.376
2003 He F, Yang XP, Srivastava DK, Wilson SH. DNA polymerase β gene expression: The promoter activator CREB-1 is upregulated in chinese hamster ovary cells by DNA alkylating agent-induced stress Biological Chemistry. 384: 19-23. PMID 12674496 DOI: 10.1515/Bc.2003.003  0.448
2003 Harrigan JA, Opresko PL, von Kobbe C, Kedar PS, Prasad R, Wilson SH, Bohr VA. The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity. The Journal of Biological Chemistry. 278: 22686-95. PMID 12665521 DOI: 10.1074/Jbc.M213103200  0.507
2003 Krahn JM, Beard WA, Miller H, Grollman AP, Wilson SH. Structure of DNA Polymerase β with the Mutagenic DNA Lesion 8-Oxodeoxyguanine Reveals Structural Insights into Its Coding Potential Structure. 11: 121-127. PMID 12517346 DOI: 10.1016/S0969-2126(02)00930-9  0.544
2003 Horton JK, Joyce-Gray DF, Pachkowski BF, Swenberg JA, Wilson SH. Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions. Dna Repair. 2: 27-48. PMID 12509266 DOI: 10.1016/S1568-7864(02)00184-2  0.498
2003 Kim SJ, Beard WA, Harvey J, Shock DD, Knutson JR, Wilson SH. Rapid segmental and subdomain motions of DNA polymerase beta. The Journal of Biological Chemistry. 278: 5072-81. PMID 12458221 DOI: 10.1074/Jbc.M208472200  0.426
2002 Horton JK, Baker A, Berg BJ, Sobol RW, Wilson SH. Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage. Dna Repair. 1: 317-33. PMID 12509250 DOI: 10.1016/S1568-7864(02)00008-3  0.44
2002 Gryk MR, Marintchev A, Maciejewski MW, Robertson A, Wilson SH, Mullen GP. Mapping of the interaction interface of DNA polymerase beta with XRCC1. Structure (London, England : 1993). 10: 1709-20. PMID 12467578 DOI: 10.1016/S0969-2126(02)00908-5  0.415
2002 Beard WA, Shock DD, Berg BJV, Wilson SH. Efficiency of correct nucleotide insertion governs DNA polymerase fidelity. Journal of Biological Chemistry. 277: 47393-47398. PMID 12370169 DOI: 10.1074/Jbc.M210036200  0.546
2002 Yang L, Beard W, Wilson S, Roux B, Broyde S, Schlick T. Local deformations revealed by dynamics simulations of DNA polymerase Beta with DNA mismatches at the primer terminus. Journal of Molecular Biology. 321: 459-78. PMID 12162959 DOI: 10.1016/S0022-2836(02)00617-4  0.527
2002 Lavrik OI, Kolpashchikov DM, Prasad R, Sobol RW, Wilson SH. Binary system for selective photoaffinity labeling of base excision repair DNA polymerases. Nucleic Acids Research. 30: e73. PMID 12136121 DOI: 10.1093/Nar/Gnf073  0.536
2002 Kedar PS, Kim SJ, Robertson A, Hou E, Prasad R, Horton JK, Wilson SH. Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen. The Journal of Biological Chemistry. 277: 31115-23. PMID 12063248 DOI: 10.1074/Jbc.M201497200  0.45
2002 Sobol RW, Watson DE, Nakamura J, Yakes FM, Hou E, Horton JK, Ladapo J, Van Houten B, Swenberg JA, Tindall KR, Samson LD, Wilson SH. Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Proceedings of the National Academy of Sciences of the United States of America. 99: 6860-5. PMID 11983862 DOI: 10.1073/Pnas.092662499  0.444
2002 Yang L, Beard WA, Wilson SH, Broyde S, Schlick T. Polymerase beta simulations suggest that Arg258 rotation is a slow step rather than large subdomain motions per se. Journal of Molecular Biology. 317: 651-71. PMID 11955015 DOI: 10.1006/Jmbi.2002.5450  0.439
2002 Gryk MR, Maciejewski MW, Robertson A, Mullen MA, Wilson SH, Mullen GP. 1H, 13C and 15N resonance assignments for the perdeuterated 22 kD palm-thumb domain of DNA polymerase beta. Journal of Biomolecular Nmr. 22: 197-8. PMID 11883786 DOI: 10.1023/A:1014237724868  0.405
2002 Idriss HT, Al-Assar O, Wilson SH. DNA polymerase β The International Journal of Biochemistry & Cell Biology. 34: 321-324. PMID 11854030 DOI: 10.1016/S1357-2725(01)00131-5  0.503
2002 Belova GI, Prasad R, Nazimov IV, Wilson SH, Slesarev AI. The domain organization and properties of individual domains of DNA topoisomerase V, a type 1B topoisomerase with DNA repair activities. Journal of Biological Chemistry. 277: 4959-4965. PMID 11733530 DOI: 10.1074/Jbc.M110131200  0.468
2001 Beard WA, Shock DD, Yang XP, DeLauder SF, Wilson SH. Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity. The Journal of Biological Chemistry. 277: 8235-42. PMID 11756435 DOI: 10.1074/Jbc.M107286200  0.525
2001 Chen KH, Srivastava DK, Wilson SH. Relationship between base excision repair capacity and DNA alkylating agent sensitivity in mouse monocytes Mutation Research - Dna Repair. 487: 121-126. PMID 11738938 DOI: 10.1016/S0921-8777(01)00110-0  0.466
2001 Beard WA, Wilson SH. DNA polymerases lose their grip Nature Structural Biology. 8: 915-917. PMID 11685231 DOI: 10.1038/Nsb1101-915  0.524
2001 Beard WA, Wilson SH. DNA lesion bypass polymerases open up Structure. 9: 759-764. PMID 11566124 DOI: 10.1016/S0969-2126(01)00646-3  0.532
2001 Sobol RW, Wilson SH. Mammalian DNA β-polymerase in base excision repair of alkylation damage Progress in Nucleic Acid Research and Molecular Biology. 68: 57-74. PMID 11554313 DOI: 10.1016/S0079-6603(01)68090-5  0.488
2001 Prasad R, Lavrik OI, Kim SJ, Kedar P, Yang XP, Vande Berg BJ, Wilson SH. DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis. The Journal of Biological Chemistry. 276: 32411-4. PMID 11440997 DOI: 10.1074/Jbc.C100292200  0.56
2001 Belova GI, Prasad R, Kozyavkin SA, Lake JA, Wilson SH, Slesarev AI. A type IB topoisomerase with DNA repair activities Proceedings of the National Academy of Sciences of the United States of America. 98: 6015-6020. PMID 11353838 DOI: 10.1073/Pnas.111040498  0.521
2001 Lavrik OI, Prasad R, Sobol RW, Horton JK, Ackerman EJ, Wilson SH. Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair. The Journal of Biological Chemistry. 276: 25541-8. PMID 11340072 DOI: 10.1074/Jbc.M102125200  0.529
2001 Bebenek K, Tissier A, Frank EG, McDonald JP, Prasad R, Wilson SH, Woodgate R, Kunkel TA. 5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro. Science (New York, N.Y.). 291: 2156-9. PMID 11251121 DOI: 10.1126/Science.1058386  0.552
2001 Srivastava DK, Tendler CL, Milani D, English MA, Licht JD, Wilson SH. The HIV-1 transactivator protein Tat is a potent inducer of the human DNA repair enzyme β-polymerase Aids. 15: 433-440. PMID 11242139 DOI: 10.1097/00002030-200103090-00001  0.383
2001 Zhou J, Ahn J, Wilson SH, Prives C. A role for p53 in base excision repair Embo Journal. 20: 914-923. PMID 11179235 DOI: 10.1093/Emboj/20.4.914  0.437
2001 Podlutsky AJ, Dianova II, Wilson SH, Bohr VA, Dianov GL. DNA synthesis and dRPase activities of polymerase beta are both essential for single-nucleotide patch base excision repair in mammalian cell extracts. Biochemistry. 40: 809-813. PMID 11170398 DOI: 10.1021/Bi002064S  0.536
2001 Vande Berg BJ, Beard WA, Wilson SH. DNA structure and aspartate 276 influence nucleotide binding to human DNA polymerase β. Implication for the identity of the rate-limiting conformational change Journal of Biological Chemistry. 276: 3408-3416. PMID 11024043 DOI: 10.1074/Jbc.M002884200  0.505
2001 Wilson SH. Session 2 gene targeting in the mouse for elucidating the role of BER Progress in Nucleic Acid Research and Molecular Biology. 68: 55. DOI: 10.1016/S0079-6603(01)68089-9  0.493
2000 Wilson SH, Sobol RW, Beard WA, Horton JK, Prasad R, Vande Berg BJ. DNA polymerase beta and mammalian base excision repair. Cold Spring Harbor Symposia On Quantitative Biology. 65: 143-55. PMID 12760029 DOI: 10.1101/Sqb.2000.65.143  0.507
2000 Narayan S, Wilson SH. Kinetic analysis of Sp1-mediated transcriptional activation of the human DNA polymerase β promoter Oncogene. 19: 4729-4735. PMID 11032023 DOI: 10.1038/Sj.Onc.1203823  0.365
2000 Beard WA, Wilson SH. Structural design of a eukaryotic DNA repair polymerase: DNA polymerase β Mutation Research - Dna Repair. 460: 231-244. PMID 10946231 DOI: 10.1016/S0921-8777(00)00029-X  0.545
2000 Sobol RW, Prasad R, Evenski A, Baker A, Yang XP, Horton JK, Wilson SH. The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity. Nature. 405: 807-10. PMID 10866204 DOI: 10.1038/35015598  0.52
2000 Osheroff WP, Beard WA, Yin S, Wilson SH, Kunkel TA. Minor groove interactions at the DNA polymerase beta active site modulate single-base deletion error rates. The Journal of Biological Chemistry. 275: 28033-8. PMID 10851238 DOI: 10.1074/Jbc.M003462200  0.464
2000 Chen KH, Srivastava DK, Singhal RK, Jacob S, Ahmed AE, Wilson SH. Modulation of base excision repair by low density lipoprotein, oxidized low density lipoprotein and antioxidants in mouse monocytes. Carcinogenesis. 21: 1017-22. PMID 10783327 DOI: 10.1093/Carcin/21.5.1017  0.379
2000 Marintchev A, Robertson A, Dimitriadis EK, Prasad R, Wilson SH, Mullen GP. Domain specific interaction in the XRCC1–DNA polymerase β complex Nucleic Acids Research. 28: 2049-2059. PMID 10773072 DOI: 10.1093/Nar/28.10.2049  0.379
2000 Deterding LJ, Prasad R, Mullen GP, Wilson SH, Tomer KB. Mapping of the 5'-2-deoxyribose-5-phosphate lyase active site in DNA polymerase β by mass spectrometry Journal of Biological Chemistry. 275: 10463-10471. PMID 10744736 DOI: 10.1074/Jbc.275.14.10463  0.36
2000 Wilson SH, Kunkel TA. Passing the baton in base excision repair Nature Structural Biology. 7: 176-178. PMID 10700268 DOI: 10.1038/73260  0.534
2000 Prasad R, Dianov GL, Bohr VA, Wilson SH. FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair. Journal of Biological Chemistry. 275: 4460-4466. PMID 10660619 DOI: 10.1074/Jbc.275.6.4460  0.538
2000 Maciejewski MW, Liu D, Prasad R, Wilson SH, Mullen GP. Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity. Journal of Molecular Biology. 296: 229-253. PMID 10656829 DOI: 10.1006/Jmbi.1999.3455  0.519
2000 Miller H, Prasad R, Wilson SH, Johnson F, Grollman AP. 8-oxodGTP incorporation by DNA polymerase beta is modified by active-site residue Asn279. Biochemistry. 39: 1029-1033. PMID 10653647 DOI: 10.1021/Bi991789X  0.451
2000 Narayan S, Wilson SH. Kinetic analysis of Sp1-mediated transcriptional activation of a TATA-containing promoter. Biochemistry. 39: 818-23. PMID 10651648 DOI: 10.1021/Bi9912701  0.311
2000 Patterson TA, Little W, Cheng X, Widen SG, Kumar A, Beard WA, Wilson SH. Molecular cloning and high-level expression of human polymerase beta cDNA and comparison of the purified recombinant human and rat enzymes. Protein Expression and Purification. 18: 100-10. PMID 10648175 DOI: 10.1006/Prep.1999.1167  0.369
2000 Horton JK, Prasad R, Hou E, Wilson SH. Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair. The Journal of Biological Chemistry. 275: 2211-8. PMID 10636928 DOI: 10.1074/Jbc.275.3.2211  0.433
2000 Li L, Pedersen LG, Beard WA, Bebenek K, Wilson SH, Kunkel TA, Darden TA. A Molecular Dynamics Model of HIV-1 Reverse Transcriptase Complexed with DNA: Comparison with Experimental Structures Journal of Molecular Modeling. 6: 575-586. DOI: 10.1007/S0089400060575  0.572
1999 Lewis DA, Bebenek K, Beard WA, Wilson SH, Kunkel TA. Uniquely altered DNA replication fidelity conferred by an amino acid change in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase. The Journal of Biological Chemistry. 274: 32924-30. PMID 10551858 DOI: 10.1074/Jbc.274.46.32924  0.382
1999 Osheroff WP, Beard WA, Wilson SH, Kunkel TA. Base substitution specificity of DNA polymerase beta depends on interactions in the DNA minor groove. The Journal of Biological Chemistry. 274: 20749-52. PMID 10409611 DOI: 10.1074/Jbc.274.30.20749  0.533
1999 Powell MD, Beard WA, Bebenek K, Howard KJ, Le Grice SF, Darden TA, Kunkel TA, Wilson SH, Levin JG. Residues in the alphaH and alphaI helices of the HIV-1 reverse transcriptase thumb subdomain required for the specificity of RNase H-catalyzed removal of the polypurine tract primer. The Journal of Biological Chemistry. 274: 19885-93. PMID 10391934 DOI: 10.1074/Jbc.274.28.19885  0.376
1999 Srivastava DK, Husain I, Arteaga CL, Wilson SH. DNA polymerase beta expression differences in selected human tumors and cell lines. Carcinogenesis. 20: 1049-54. PMID 10357787 DOI: 10.1093/Carcin/20.6.1049  0.399
1999 Efrati E, Tocco G, Eritja R, Wilson SH, Goodman MF. "Action-at-a-distance" mutagenesis. 8-oxo-7, 8-dihydro-2'-deoxyguanosine causes base substitution errors at neighboring template sites when copied by DNA polymerase beta. The Journal of Biological Chemistry. 274: 15920-6. PMID 10336498 DOI: 10.1074/jbc.274.22.15920  0.41
1999 Dianov GL, Prasad R, Wilson SH, Bohr VA. Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair. Journal of Biological Chemistry. 274: 13741-13743. PMID 10318775 DOI: 10.1074/Jbc.274.20.13741  0.486
1999 Osheroff WP, Jung HK, Beard WA, Wilson SH, Kunkel TA. The Fidelity of DNA Polymerase β during Distributive and Processive DNA Synthesis Journal of Biological Chemistry. 274: 3642-3650. PMID 9920913 DOI: 10.1074/Jbc.274.6.3642  0.463
1999 Liu D, DeRose E, Prasad R, Wilson S, Mullen G. Complete 1H, 13C, and 15N Chemical Shift Assignments for the N-terminal Domain of DNA Polymerase B (residues 2-87). Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr4326  0.36
1998 Beard WA, Bebenek K, Darden TA, Li L, Prasad R, Kunkel TA, Wilson SH. Vertical-scanning mutagenesis of a critical tryptophan in the minor groove binding track of HIV-1 reverse transcriptase. Molecular nature of polymerase-nucleic acid interactions. The Journal of Biological Chemistry. 273: 30435-42. PMID 9804810 DOI: 10.1074/Jbc.273.46.30435  0.503
1998 Stucki M, Pascucci B, Parlanti E, Fortini P, Wilson SH, Hübscher U, Dogliotti E. Mammalian base excision repair by DNA polymerases δ and ε Oncogene. 17: 835-843. PMID 9780000 DOI: 10.1038/Sj.Onc.1202001  0.483
1998 Longley MJ, Prasad R, Srivastava DK, Wilson SH, Copeland WC. Identification of 5′-deoxyribose phosphate lyase activity in human DNA polymerase γ and its role in mitochondrial base excision repair in vitro Proceedings of the National Academy of Sciences of the United States of America. 95: 12244-12248. PMID 9770471 DOI: 10.1073/Pnas.95.21.12244  0.531
1998 Srivastava DK, Berg BJ, Prasad R, Molina JT, Beard WA, Tomkinson AE, Wilson SH. Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps. The Journal of Biological Chemistry. 273: 21203-9. PMID 9694877 DOI: 10.1074/Jbc.273.33.21203  0.556
1998 Dimitriadis EK, Prasad R, Vaske MK, Chen L, Tomkinson AE, Lewis MS, Wilson SH. Thermodynamics of human DNA ligase I trimerization and association with DNA polymerase beta. The Journal of Biological Chemistry. 273: 20540-50. PMID 9685411 DOI: 10.1074/Jbc.273.32.20540  0.485
1998 Wilson SH. Mammalian base excision repair and DNA polymerase beta Mutation Research - Dna Repair. 407: 203-215. PMID 9653447 DOI: 10.1016/S0921-8777(98)00002-0  0.507
1998 Prasad R, Beard WA, Chyan JY, Maciejewski MW, Mullen GP, Wilson SH. Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities. The Journal of Biological Chemistry. 273: 11121-6. PMID 9556598 DOI: 10.1074/jbc.273.18.11121  0.443
1998 Fortini P, Pascucci B, Parlanti E, Sobol RW, Wilson SH, Dogliotti E. Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells Biochemistry. 37: 3575-3580. PMID 9530283 DOI: 10.1021/Bi972999H  0.485
1998 Chen KH, Yakes FM, Srivastava DK, Singhal RK, Sobol RW, Horton JK, Van Houten B, Wilson SH. Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines. Nucleic Acids Research. 26: 2001-7. PMID 9518496 DOI: 10.1093/Nar/26.8.2001  0.448
1998 Beard WA, Wilson SH. Structural insights into DNA polymerase β fidelity: Hold tight if you want it right Chemistry and Biology. 5. PMID 9479474 DOI: 10.1016/S1074-5521(98)90081-3  0.516
1998 Kunkel TA, Wilson SH. DNA polymerases on the move Nature Structural Biology. 5: 95-99. PMID 9461069 DOI: 10.1038/Nsb0298-95  0.524
1998 Singh SB, Beard WA, Hingerty BE, Wilson SH, Broyde S. Interactions between DNA polymerase beta and the major covalent adduct of the carcinogen (+)-anti-benzo[a]pyrene diol epoxide with DNA at a primer-template junction. Biochemistry. 37: 878-84. PMID 9454577 DOI: 10.1021/Bi9720639  0.507
1998 Biade S, Sobol RW, Wilson SH, Matsumoto Y. Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA Journal of Biological Chemistry. 273: 898-902. PMID 9422747 DOI: 10.1074/Jbc.273.2.898  0.51
1998 Lavrik OI, Nasheuer HP, Weisshart K, Wold MS, Prasad R, Beard WA, Wilson SH, Favre A. Subunits of human replication protein A are crosslinked by photoreactive primers synthesized by DNA polymerases. Nucleic Acids Research. 26: 602-7. PMID 9421522 DOI: 10.1093/Nar/26.2.602  0.536
1997 Yang X, He F, Rawson TY, Wilson SH. Human DNA polymerase-β promoter: Phorbol ester activation is mediated through the cAMP response element and cAMP-response-element-binding protein Journal of Biomedical Science. 4: 279-288. PMID 12386374 DOI: 10.1007/Bf02258351  0.417
1997 Sawaya MR, Prasad R, Wilson SH, Kraut J, Pelletier H. Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Biochemistry. 36: 11205-15. PMID 9287163 DOI: 10.1021/Bi9703812  0.547
1997 Mullen GP, Wilson SH. DNA polymerase β in abasic site repair: A structurally conserved helix- hairpin-helix motif in lesion detection by base excision repair enzymes Biochemistry. 36: 4713-4717. PMID 9125491 DOI: 10.1021/Bi962363A  0.496
1997 Butler AP, Johnson DG, Kumar AP, Narayan S, Wilson SH, MacLeod MC. Disruption of transcription in vitro and gene expression in vivo by DNA adducts derived from a benzo[a]pyrene diol epoxide located in heterologous sequences. Carcinogenesis. 18: 239-44. PMID 9054613 DOI: 10.1093/Carcin/18.2.239  0.424
1997 Mullen GP, Antuch W, Maciejewski MW, Prasad R, Wilson SH. Insights into the mechanism of the β-elimination catalyzed by the N-terminal domain of DNA polymerase β Tetrahedron. 53: 12057-12066. DOI: 10.1016/S0040-4020(97)00768-0  0.454
1997 Kunkel T, Bebenek K, Osheroff W, Beard W, Prasad R, Wilson S, Darden T, Li L, Luxon B, Gorenstein D, Sawaya M, Kraut J. O XI A.1 Structure-function studies of DNA polymerase error specificity Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 379: S77. DOI: 10.1016/S0027-5107(97)82862-X  0.403
1997 Fortini P, Pascucci B, Sobol R, Wilson S, Dogliotti E. P IV.6 Base excision repair in mammalian cells occurs also in the absence of DNA polymerase β Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 379: S29. DOI: 10.1016/S0027-5107(97)82690-5  0.494
1996 Pelletier H, Sawaya MR, Wolfle W, Wilson SH, Kraut J. A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta. Biochemistry. 35: 12762-77. PMID 8841119 DOI: 10.1021/Bi9529566  0.456
1996 Pelletier H, Sawaya MR, Wolfle W, Wilson SH, Kraut J. Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity. Biochemistry. 35: 12742-61. PMID 8841118 DOI: 10.1021/Bi952955D  0.54
1996 Chyan YJ, Strauss PR, Wood TG, Wilson SH. Identification of novel mRNA isoforms for human DNA polymerase beta. Dna and Cell Biology. 15: 653-9. PMID 8769567 DOI: 10.1089/Dna.1996.15.653  0.362
1996 Lavrik OI, Prasad R, Beard WA, Safronov IV, Dobrikov MI, Srivastava DK, Shishkin GV, Wood TG, Wilson SH. dNTP binding to HIV-1 reverse transcriptase and mammalian DNA polymerase beta as revealed by affinity labeling with a photoreactive dNTP analog. The Journal of Biological Chemistry. 271: 21891-7. PMID 8702991 DOI: 10.1074/JBC.271.36.21891  0.303
1996 Reha-Krantz LJ, Nonay RL, Day RS, Wilson SH. Replication of O6-methylguanine-containing DNA by repair and replicative DNA polymerases. The Journal of Biological Chemistry. 271: 20088-95. PMID 8702729 DOI: 10.1074/Jbc.271.33.20088  0.438
1996 Narayan S, He F, Wilson SH. Activation of the human DNA polymerase β promoter by a DNA-alkylating agent through induced phosphorylation of cAMP response element-binding protein-1 Journal of Biological Chemistry. 271: 18508-18513. PMID 8702497 DOI: 10.1074/jbc.271.31.18508  0.327
1996 Piersen CE, Prasad R, Wilson SH, Lloyd RS. Evidence for an imino intermediate in the DNA polymerase β deoxyribose phosphate excision reaction Journal of Biological Chemistry. 271: 17811-17815. PMID 8663612 DOI: 10.1074/jbc.271.30.17811  0.412
1996 Prasad R, Singhal RK, Srivastava DK, Molina JT, Tomkinson AE, Wilson SH. Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testis. The Journal of Biological Chemistry. 271: 16000-7. PMID 8663274 DOI: 10.1074/Jbc.271.27.16000  0.361
1996 Oda N, Saxena JK, Jenkins TM, Prasad R, Wilson SH, Ackerman EJ. DNA polymerases alpha and beta are required for DNA repair in an efficient nuclear extract from Xenopus oocytes. The Journal of Biological Chemistry. 271: 13816-20. PMID 8662731 DOI: 10.1074/jbc.271.23.13816  0.434
1996 Beard WA, Osheroff WP, Prasad R, Sawaya MR, Jaju M, Wood TG, Kraut J, Kunkel TA, Wilson SH. Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta. The Journal of Biological Chemistry. 271: 12141-4. PMID 8647805 DOI: 10.1074/Jbc.271.21.12141  0.378
1996 He F, Narayan S, Wilson SH. Purification and characterization of a DNA polymerase β promoter initiator element-binding transcription factor from bovine testis Biochemistry. 35: 1775-1782. PMID 8639658 DOI: 10.1021/Bi9525987  0.427
1996 Liu D, Prasad R, Wilson SH, DeRose EF, Mullen GP. Three-dimensional solution structure of the N-terminal domain of DNA polymerase beta and mapping of the ssDNA interaction interface. Biochemistry. 35: 6188-200. PMID 8639559 DOI: 10.1021/Bi952656O  0.389
1996 Srivastava DK, Evans RK, Kumar A, Beard WA, Wilson SH. dNTP binding site in rat DNA polymerase beta revealed by controlled proteolysis and azido photoprobe cross-linking. Biochemistry. 35: 3728-34. PMID 8619993 DOI: 10.1021/Bi952632H  0.383
1996 Sobol RW, Horton JK, Kühn R, Gu H, Singhal RK, Prasad R, Rajewsky K, Wilson SH. Requirement of mammalian DNA polymerase-beta in base-excision repair. Nature. 379: 183-6. PMID 8538772 DOI: 10.1038/379183A0  0.441
1996 Sobol RW, Norton JK, Kühn R, Gu H, Singhal RK, Prasad R, Rajewsky K, Wilson SH. Correction: Requirement of mammalian DNA polymerase-β in base-excision repair Nature. 383: 457-457. DOI: 10.1038/383457B0  0.379
1996 Sobol RW, Norton JK, Kühn R, Gu H, Singhal RK, Prasad R, Rajewsky K, Wilson SH. Requirement of mammalian DNA polymerase-β in base-excision repair Nature. 379: 848-848. DOI: 10.1038/379848b0  0.417
1995 Beard WA, Wilson SH. Purification and domain-mapping of mammalian DNA polymerase β Methods in Enzymology. 262: 98-107. PMID 8594388 DOI: 10.1016/0076-6879(95)62013-3  0.45
1995 Singhal RK, Prasad R, Wilson SH. DNA polymerase β conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract Journal of Biological Chemistry. 270: 949-957. PMID 7822335 DOI: 10.1074/jbc.270.2.949  0.465
1995 Narayan S, Beard WA, Wilson SH. DNA damage-induced transcriptional activation of a human DNA polymerase beta chimeric promoter: recruitment of preinitiation complex in vitro by ATF/CREB. Biochemistry. 34: 73-80. PMID 7819226 DOI: 10.1021/Bi00001A009  0.471
1995 Srivastava DK, Rawson TY, Showalter SD, Wilson SH. Phorbol ester abrogates up-regulation of DNA polymerase β by DNA-alkylating agents in Chinese hamster ovary cells Journal of Biological Chemistry. 270: 16402-16408. PMID 7608211 DOI: 10.1074/JBC.270.27.16402  0.398
1995 Horton JK, Srivastava DK, Zmudzka BZ, Wilson SH. Strategic down-regulation of DNA polymerase beta by antisense RNA sensitizes mammalian cells to specific DNA damaging agents. Nucleic Acids Research. 23: 3810-5. PMID 7479021 DOI: 10.1093/NAR/23.19.3810  0.375
1994 Prasad R, Widen SG, Singhal RK, Watkins J, Prakash L, Wilson SH. Yeast open reading frame YCR14C encodes a DNA beta-polymerase-like enzyme. Nucleic Acids Research. 21: 5301-7. PMID 8265341 DOI: 10.1093/Nar/21.23.5301  0.454
1994 Liu D, DeRose EF, Prasad R, Wilson SH, Mullen GP. Assignments of 1H, 15N, and 13C resonances for the backbone and side chains of the N-terminal domain of DNA polymerase beta. Determination of the secondary structure and tertiary contacts. Biochemistry. 33: 9537-45. PMID 8068628 DOI: 10.1021/Bi00198A020  0.407
1994 Kim SJ, Lewis MS, Knutson JR, Porter DK, Kumar A, Wilson SH. Characterization of the tryptophan fluorescence and hydrodynamic properties of rat DNA polymerase beta. Journal of Molecular Biology. 244: 224-35. PMID 7966332 DOI: 10.1006/Jmbi.1994.1720  0.362
1994 Sawaya MR, Pelletier H, Kumar A, Wilson SH, Kraut J. Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism. Science (New York, N.Y.). 264: 1930-5. PMID 7516581 DOI: 10.1126/Science.7516581  0.493
1994 Pelletier H, Sawaya MR, Kumar A, Wilson SH, Kraut J. Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP. Science (New York, N.Y.). 264: 1891-903. PMID 7516580 DOI: 10.1126/Science.7516580  0.526
1994 Pelletier H, Sawaya M, Kumar A, Wilson S, Kraut J. Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP Science. 264: 1891-1903. DOI: 10.1126/SCIENCE.7516580  0.413
1993 Sobol RW, Fisher WL, Reichenbach NL, Kumar A, Beard WA, Wilson SH, Charubala R, Pfleiderer W, Suhadolnik RJ. HIV-1 reverse transcriptase: inhibition by 2',5'-oligoadenylates. Biochemistry. 32: 12112-8. PMID 7692966 DOI: 10.1021/Bi00096A023  0.306
1993 Beard WA, Wilson SH. Kinetic analysis of template.primer interactions with recombinant forms of HIV-1 reverse transcriptase. Biochemistry. 32: 9745-53. PMID 7690592 DOI: 10.1021/Bi00088A029  0.323
1993 Becerra SP, Kumar A, Wilson SH. Expression of Polypeptides of Human Immunodeficiency Virus-1 Reverse Transcriptase in Escherichia coli Protein Expression and Purification. 4: 187-199. DOI: 10.1006/Prep.1993.1025  0.317
1992 Englander EW, Wilson SH. DNA damage response of cloned DNA β-polymerase promoter is blocked in mutant cell lines deficient in protein kinase A Nucleic Acids Research. 20: 5527-5531. PMID 1454516 DOI: 10.1093/Nar/20.21.5527  0.484
1992 Casas-Finet JR, Kumar A, Karpel RL, Wilson SH. Mammalian DNA polymerase beta: characterization of a 16-kDa transdomain fragment containing the nucleic acid-binding activities of the native enzyme. Biochemistry. 31: 10272-10280. PMID 1420147 DOI: 10.1021/Bi00157A014  0.479
1992 Jenkins TM, Saxena JK, Kumar A, Wilson SH, Ackerman EJ. DNA polymerase beta and DNA synthesis in Xenopus oocytes and in a nuclear extract. Science (New York, N.Y.). 258: 475-8. PMID 1411545 DOI: 10.1126/Science.1411545  0.501
1992 Englander EW, Wilson SH. The cloned promoter of the human DNA β-polymerase gene contains a cAMP response element functional in HeLa cells Dna and Cell Biology. 11: 61-69. PMID 1310859 DOI: 10.1089/Dna.1992.11.61  0.425
1992 Abbotts J, Wilson SH. Inhibitors of HIV-1 reverse transcriptase and fidelity of in vitro DNA replication Journal of Enzyme Inhibition and Medicinal Chemistry. 6: 35-46. PMID 1285301 DOI: 10.3109/14756369209041354  0.371
1991 Nadler SG, Merrill BM, Roberts WJ, Keating KM, Lisbin MJ, Barnett SF, Wilson SH, Williams KR. Interactions of the A1 heterogeneous nuclear ribonucleoprotein and its proteolytic derivative, UP1, with RNA and DNA: evidence for multiple RNA binding domains and salt-dependent binding mode transitions. Biochemistry. 30: 2968-76. PMID 1848781 DOI: 10.1021/Bi00225A034  0.336
1991 Englander EW, Widen SG, Wilson SH. Mammalian β-polymerase promoter: Phosphorylation of ATF/CRE-binding protein and regulation of DNA binding Nucleic Acids Research. 19: 3369-3375. PMID 1829517 DOI: 10.1093/Nar/19.12.3369  0.474
1991 Widen SG, Wilson SH. Mammalian β-polyrnerase promoter: Large-scale purification and properties of ATF/CREB palindrome binding protein from bovine testes Biochemistry. 30: 6296-6305. PMID 1829381 DOI: 10.1021/Bi00239A031  0.36
1991 Kedar PS, Widen SG, Englander EW, Fornace AJ, Wilson SH. The ATF/CREB transcription factor-binding site in the polymerase beta promoter mediates the positive effect of N-methyl-N'-nitro-N-nitrosoguanidine on transcription. Proceedings of the National Academy of Sciences of the United States of America. 88: 3729-33. PMID 1827204 DOI: 10.1073/Pnas.88.9.3729  0.415
1991 Sobol RW, Suhadolnik RJ, Kumar A, Lee BJ, Hatfield DL, Wilson SH. Localization of a polynucleotide binding region in the HIV-1 reverse transcriptase: Implications for primer binding Biochemistry. 30: 10623-10631. PMID 1718424 DOI: 10.1021/Bi00108A004  0.349
1990 Englander EW, Wilson SH. Protein binding elements in the human β-polymerase promoter Nucleic Acids Research. 18: 919-928. PMID 2315044 DOI: 10.1093/Nar/18.4.919  0.342
1990 Jeang KT, Widen S, Semmes OJ, Wilson SH. HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene Science. 247: 1082-1084. PMID 2309119 DOI: 10.1126/Science.2309119  0.385
1990 Kumar A, Abbotts J, Karawya EM, Wilson SH. Identification and properties of the catalytic domain of mammalian DNA polymerase β Biochemistry. 29: 7156-7159. PMID 2207097 DOI: 10.1021/Bi00483A002  0.398
1990 Kumar A, Wilson SH. Studies of the strand-annealing activity of mammalian hnRNP complex protein A1 Biochemistry. 29: 10717-10722. PMID 1703006 DOI: 10.1021/Bi00500A001  0.348
1990 Zmudzka BZ, Wilson SH. Deregulation of DNA polymerase β by sense and antisense RNA expression in mouse 3T3 cells alters cell growth Somatic Cell and Molecular Genetics. 16: 311-320. PMID 1699288 DOI: 10.1007/Bf01232459  0.403
1990 Kedar PS, Abbotts J, Kovács T, Lesiak K, Torrence P, Wilson SH. Mechanism of HIV reverse transcriptase: enzyme-primer interaction as revealed through studies of a dNTP analogue, 3'-azido-dTTP. Biochemistry. 29: 3603-11. PMID 1692732 DOI: 10.1021/Bi00467A003  0.407
1989 Nowak R, Siedlecki JA, Kaczmarek L, Zmudzka BZ, Wilson SH. Levels and size complexity of DNA polymerase beta mRNA in rat regenerating liver and other organs. Biochimica Et Biophysica Acta. 1008: 203-7. PMID 2736248 DOI: 10.1016/0167-4781(80)90010-X  0.34
1989 Basu A, Kedar P, Wilson SH, Modak MJ. Active-site modification of mammalian DNA polymerase β with pyridoxal 5′-phosphate: Mechanism of inhibition and identification of lysine 71 in the deoxynucleoside triphosphate binding pocket Biochemistry. 28: 6305-6309. PMID 2506925 DOI: 10.1021/Bi00441A023  0.461
1989 Majumdar C, Stein CA, Cohen JS, Broder S, Wilson SH. Stepwise mechanism of HIV reverse transcriptase: Primer function of phosphorothioate oligodeoxynucleotide Biochemistry. 28: 1340-1346. PMID 2469468 DOI: 10.1021/Bi00429A060  0.389
1988 Abbotts J, SenGupta DN, Zmudzka B, Widen SG, Notario V, Wilson SH. Expression of human DNA polymerase β in Escherichia coli and characterization of the recombinant enzyme Biochemistry. 27: 901-909. PMID 3284575 DOI: 10.1021/Bi00403A010  0.45
1988 Wilson S, Abbotts J, Widen S. Progress toward molecular biology of DNA polymerase beta. Biochimica Et Biophysica Acta. 949: 149-57. PMID 3277667 DOI: 10.1016/0167-4781(88)90078-4  0.467
1988 Zmudzka BZ, Fomace A, Collins J, Wilson SH. Characterization of DNA polymerase β mRNA: Cell-cycle and growth response in cultured human cells Nucleic Acids Research. 16: 9587-9596. PMID 2460824 DOI: 10.1093/Nar/16.20.9587  0.416
1987 McBride OW, Zmudzka BZ, Wilson SH. Chromosomal location of the human gene for DNA polymerase β Proceedings of the National Academy of Sciences of the United States of America. 84: 503-507. PMID 3467369 DOI: 10.1073/pnas.84.2.503  0.415
1987 Anderson RS, Lawrence CB, Wilson SH, Beattie KL. Genetic relatedness of human DNA polymerase β and terminal deoxynucleotidyltransferase Gene. 60: 163-173. PMID 3443300 DOI: 10.1016/0378-1119(87)90224-1  0.337
1987 Cobianchi F, Wilson SH. Enzymes for modifying and labeling DNA and RNA Methods in Enzymology. 152: 94-110. PMID 2443813 DOI: 10.1016/0076-6879(87)52013-4  0.355
1986 Zmudzka BZ, SenGupta D, Matsukage A, Cobianchi F, Kumar P, Wilson SH. Structure of rat DNA polymerase beta revealed by partial amino acid sequencing and cDNA cloning. Proceedings of the National Academy of Sciences of the United States of America. 83: 5106-10. PMID 2873575 DOI: 10.1073/Pnas.83.14.5106  0.361
1986 SenGupta DN, Zmudzka BZ, Kumar P, Cobianchi F, Skowronski J, Wilson SH. Sequence of human DNA polymerase beta mRNA obtained through cDNA cloning. Biochemical and Biophysical Research Communications. 136: 341-7. PMID 2423078 DOI: 10.1016/0006-291X(86)90916-2  0.343
1985 Karawya E, Swack J, Albert W, Fedorko J, Minna JD, Wilson SH. Identification of a higher molecular weight DNA polymerase alpha catalytic polypeptide in monkey cells by monoclonal antibody. Proceedings of the National Academy of Sciences of the United States of America. 81: 7777-81. PMID 6393127 DOI: 10.1073/Pnas.81.24.7777  0.487
1985 Mitchell JB, Karawya E, Kinsella TJ, Wilson SH. Measurement of DNA polymerase β in skin fibroblast cell lines from patients with ataxia telangiectasia Mutation Research Dna Repair Reports. 146: 295-300. PMID 4058446 DOI: 10.1016/0167-8817(85)90071-9  0.428
1985 Swack JA, Karawya E, Albert W, Fedorko J, Minna JD, Wilson SH. Properties and applications of new monoclonal antibodies raised against calf DNA polymerase alpha. Analytical Biochemistry. 147: 10-21. PMID 4025810 DOI: 10.1016/0003-2697(85)90003-X  0.315
1984 Detera-Wadleigh S, Karawya E, Wilson SH. Synthesis of DNA polymerase by in vitro translation of calf RNA Biochemical and Biophysical Research Communications. 122: 420-427. PMID 6743342 DOI: 10.1016/0006-291X(84)90492-3  0.422
1984 Becerra SP, Wilson SH. Properties of a novel oligonucleotide-releasing bidirectional DNA exonuclease from mouse myeloma Biochemistry. 23: 908-914. PMID 6538798 DOI: 10.1021/Bi00300A018  0.431
1984 Hazra AK, Detera-Wadleigh S, Wilson SH. Site-specific modification of Escherichia coli DNA polymerase I large fragment with pyridoxal 5′-phosphate Biochemistry. 23: 2073-2078. PMID 6426512 DOI: 10.1021/Bi00304A030  0.512
1984 Detera-Wadleigh S, Karawya E, Wilson SH. Synthesis of catalytically active polymerase alpha by in vitro translation of calf RNA Advances in Experimental Medicine and Biology. 179: 343-353. PMID 6084407 DOI: 10.1007/978-1-4684-8730-5_36  0.386
1983 Becerra SP, Detera SD, Wilson SH. Anomalous electrophoretic migration of oligodeoxynucleotides with terminal OH groups: Applications for DNA exonuclease characterization Analytical Biochemistry. 129: 200-206. PMID 6859523 DOI: 10.1016/0003-2697(83)90069-6  0.456
1983 Karawya E, Swack JA, Wilson SH. Improved conditions for activity gel analysis of DNA polymerase catalytic polypeptides Analytical Biochemistry. 135: 318-325. PMID 6660508 DOI: 10.1016/0003-2697(83)90689-9  0.475
1983 Tanabe K, Karawya E, Fewell JW, Kuff EL, Wilson SH. DNA polymerase and simian virus 40 infection of resting monkey cells: Induction of aphidicolin resistant α-polymerase Nucleic Acids Research. 11: 8253-8268. DOI: 10.1093/Nar/11.23.8253  0.401
1982 Albert W, Grummt F, Hübscher U, Wilson SH. Structural homology among calf thymus α-polymerase polypeptides Nucleic Acids Research. 10: 935-946. PMID 7063421 DOI: 10.1093/Nar/10.3.935  0.328
1980 Planck SR, Tanabe K, Wilson SH. Distinction between mouse DNA polymerases α and β by tryptic peptide mapping Nucleic Acids Research. 8: 2771-2782. PMID 7433094 DOI: 10.1093/Nar/8.12.2771  0.33
1979 Tanabe K, Bohn EW, Wilson SH. Steady-state kinetics of mouse DNA polymerase beta. Biochemistry. 18: 3401-3406. PMID 465481 DOI: 10.1021/Bi00582A029  0.477
1979 Minna JD, Marshall TH, Brown SH, Burk RD, Lemons RS, Wilson SH. Regulation of expression of type C virion DNA polymerase (reverse transcriptase) in human x mouse and human x rat hybrid cells. Somatic Cell Genetics. 5: 991-1011. PMID 94700 DOI: 10.1007/Bf01542656  0.423
1978 Wilson SH, Matsukage A, Bohn EW, Chen YC, Sivarajan M. Polynucleotide recognition by DNA alpha-polymerase. Nucleic Acids Research. 4: 3981-96. PMID 593896 DOI: 10.1093/Nar/4.11.3981  0.459
1978 Pitha J, Wilson SH, Pitha PM. A vinyl polymer with purine residues deficient in base pairing inhibits murine leukemia virus replication Biochemical and Biophysical Research Communications. 81: 217-223. PMID 207272 DOI: 10.1016/0006-291X(78)91652-2  0.408
1976 Schrier BK, Wilson SH. On the measurement of tritium in DNA and its application to the assay of DNA polymerase activity Methods in Cell Biology. 105-120. PMID 1263849 DOI: 10.1016/S0091-679X(08)61799-9  0.482
1976 Pitha J, Wilson SH. Template specific inhibitor of mammalian DNA polymerases. Nucleic Acids Research. 3: 825-34. PMID 944916 DOI: 10.1093/Nar/3.3.825  0.484
1976 Kuff EL, Lueders KK, Orenstein JM, Wilson SH. Differential response of type C and intracisternal type A particle markers in cells treated with iododeoxyuridine and dexamethasone. Journal of Virology. 19: 709-16. PMID 183020 DOI: 10.1128/Jvi.19.2.709-716.1976  0.305
1975 Matsukage A, Bohn EW, Wilson SH. Differential sensitivity of low molecular weight DNA polymerase to sulfhydryl-blocking reagents Bba Section Nucleic Acids and Protein Synthesis. 383: 338-343. PMID 1167793 DOI: 10.1016/0005-2787(75)90062-3  0.408
1975 Matsukage A, Bohn EW, Wilson SH. On the DNA polymerase III of mouse myeloma: Partial purification and characterization Biochemistry. 14: 1006-1020. PMID 235942 DOI: 10.1021/Bi00676A020  0.527
1974 Matsukage A, Bohn EW, Wilson SH. Multiple forms of DNA polymerase in mouse myeloma Proceedings of the National Academy of Sciences of the United States of America. 71: 578-582. PMID 4521824 DOI: 10.1073/Pnas.71.2.578  0.514
1974 Stromberg K, Wilson SH. Structural studies of avian myeloblastosis virus. Selective release of ribonucleoprotein polypeptides from the core component and partial purification of the DNA polymerase Bba Section Nucleic Acids and Protein Synthesis. 361: 53-58. PMID 4376423 DOI: 10.1016/0005-2787(74)90208-1  0.366
1974 Bohn EW, Matsukage A, Wilson SH. Stimulation of DNA polymerase activity by the combination of p-hydroxymercuribenzoate and dithiothreitol Biochemical and Biophysical Research Communications. 59: 243-251. PMID 4366959 DOI: 10.1016/S0006-291X(74)80199-3  0.48
1974 Minna JD, Gazdar AF, Iverson GM, Marshall TH, STORMBERG K, Wilson SH. Oncornavirus expression in human x mouse hybrid cells segregating mouse chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 71: 1695-700. PMID 4366059 DOI: 10.1073/Pnas.71.5.1695  0.335
1973 Schrier BK, Wilson SH. Investigation of methods for measurement of radioactivity in tritiated DNA and applications to assays for DNA polymerase activity Analytical Biochemistry. 56: 196-207. PMID 4797195 DOI: 10.1016/0003-2697(73)90184-X  0.417
1973 Wilson SH, Kuff EL, Bohn EW, Lueders KK. Studies on DNA synthesis in murine myeloma. II. Activation of latent RNA-dependent DNA polymerase activity in membrane fractions. Biochemical and Biophysical Research Communications. 49: 1093-9. PMID 4641706 DOI: 10.1016/0006-291X(72)90325-7  0.45
1972 Wilson SH, Kuff EL. A novel DNA polymerase activity found in association with intracisternal A-type particles Proceedings of the National Academy of Sciences of the United States of America. 69: 1531-1536. PMID 4504367 DOI: 10.1073/Pnas.69.6.1531  0.473
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