Dalila G. Ordonez - Related publications

2013-2018 Molecular & Cellular Biology Harvard University, Cambridge, MA, United States 
 2014-2018 Pathology Brigham & Women's Hospital, Harvard Medical School, Boston, MA, United States 
synaptic plasticity, neurodegeneration
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50 most relevant papers in past 60 days:
Year Citation  Score
2019 Ryan P, Xu M, Davey AK, Danon JJ, Mellick GD, Kassiou M, Rudrawar S. The O-GlcNAc modification protects against protein misfolding and aggregation in neurodegenerative disease. Acs Chemical Neuroscience. PMID 30985105 DOI: 10.1021/acschemneuro.9b00143   
2019 Mehra S, Sahay S, Maji SK. α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis. Biochimica Et Biophysica Acta. Proteins and Proteomics. PMID 30853581 DOI: 10.1016/j.bbapap.2019.03.001   
2019 Wang Q, Wang C, Ji B, Zhou J, Yang C, Chen J. Hapln2 in Neurological Diseases and Its Potential as Therapeutic Target. Frontiers in Aging Neuroscience. 11: 60. PMID 30949044 DOI: 10.3389/fnagi.2019.00060   
2019 Bennett SA, Cobos SN, Meykler M, Fallah M, Rana N, Chen K, Torrente MP. Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models. Journal of Visualized Experiments : Jove. PMID 30958470 DOI: 10.3791/59104   
2019 Liu C, Fang Y. New insights of poly(ADP-ribosylation) in neurodegenerative diseases: a focus on protein phase separation and pathologic aggregation. Biochemical Pharmacology. PMID 31034795 DOI: 10.1016/j.bcp.2019.04.028   
2019 Connor-Robson N, Booth H, Martin JG, Gao B, Li K, Doig N, Vowles J, Browne C, Klinger L, Juhasz P, Klein C, Cowley SA, Bolam P, Hirst W, Wade-Martins R. An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Neurobiology of Disease. PMID 30954703 DOI: 10.1016/j.nbd.2019.04.005   
2019 Bieri G, Brahic M, Bousset L, Couthouis J, Kramer NJ, Ma R, Nakayama L, Monbureau M, Defensor E, Schüle B, Shamloo M, Melki R, Gitler AD. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons. Acta Neuropathologica. PMID 30927072 DOI: 10.1007/s00401-019-01995-0   
2019 Green C, Sydow A, Vogel S, Anglada-Huguet M, Wiedermann D, Mandelkow E, Mandelkow EM, Hoehn M. Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer's disease mouse model. Molecular Neurodegeneration. 14: 13. PMID 30917861 DOI: 10.1186/s13024-019-0316-6   
2019 Giau VV, Senanarong V, Bagyinszky E, An SSA, Kim S. Analysis of 50 Neurodegenerative Genes in Clinically Diagnosed Early-Onset Alzheimer's Disease. International Journal of Molecular Sciences. 20. PMID 30917570 DOI: 10.3390/ijms20061514   
2019 Perrino G, Wilson C, Santorelli M, di Bernardo D. Quantitative Characterization of α-Synuclein Aggregation in Living Cells through Automated Microfluidics Feedback Control. Cell Reports. 27: 916-927.e5. PMID 30995486 DOI: 10.1016/j.celrep.2019.03.081   
2019 Taylor LM, McMillan PJ, Kraemer BC, Liachko NF. Tau tubulin kinases in proteinopathy. The Febs Journal. PMID 31034749 DOI: 10.1111/febs.14866   
2019 Galts CPC, Bettio LEB, Jewett DC, Yang CC, Brocardo PS, Rodrigues ALS, Thacker JS, Gil-Mohapel J. Depression in Neurodegenerative Diseases: Common Mechanisms and Current Treatment Options. Neuroscience and Biobehavioral Reviews. PMID 30995512 DOI: 10.1016/j.neubiorev.2019.04.002   
2019 O'Bryant SE, Ferman TJ, Zhang F, Hall J, Pedraza O, Wszolek ZK, Como T, Julovich D, Mattevada S, Johnson LA, Edwards M, Hall J, Graff-Radford NR. A proteomic signature for dementia with Lewy bodies. Alzheimer's & Dementia (Amsterdam, Netherlands). 11: 270-276. PMID 30923734 DOI: 10.1016/j.dadm.2019.01.006   
2019 Falcon B, Zivanov J, Zhang W, Murzin AG, Garringer HJ, Vidal R, Crowther RA, Newell KL, Ghetti B, Goedert M, Scheres SHW. Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature. PMID 30894745 DOI: 10.1038/s41586-019-1026-5   
2019 Chen Y, Xu S, Wang N, Ma Q, Peng P, Yu Y, Zhang L, Ying Z, Wang H. Dynasore Suppresses mTORC1 Activity and Induces Autophagy to Regulate the Clearance of Protein Aggregates in Neurodegenerative Diseases. Neurotoxicity Research. PMID 30924108 DOI: 10.1007/s12640-019-00027-9   
2019 Woo JA, Liu T, Fang CC, Cazzaro S, Kee T, LePochat P, Yrigoin K, Penn C, Zhao X, Wang X, Liggett SB, Kang DE. Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics. Communications Biology. 2: 112. PMID 30911686 DOI: 10.1038/s42003-019-0359-9   
2019 Siddiqi FH, Menzies FM, Lopez A, Stamatakou E, Karabiyik C, Ureshino R, Ricketts T, Jimenez-Sanchez M, Esteban MA, Lai L, Tortorella MD, Luo Z, Liu H, Metzakopian E, Fernandes HJR, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing. Nature Communications. 10: 1817. PMID 31000720 DOI: 10.1038/s41467-019-09494-2   
2019 Ruankham W, Suwanjang W, Wongchitrat P, Prachayasittikul V, Prachayasittikul S, Phopin K. Sesamin and sesamol attenuate HO -induced oxidative stress on human neuronal cells via the SIRT1-SIRT3-FOXO3a signaling pathway. Nutritional Neuroscience. 1-12. PMID 30929586 DOI: 10.1080/1028415X.2019.1596613   
2019 Malcolm JC, Breuillaud L, Do Carmo S, Hall H, Welikovitch LA, Macdonald JA, Goedert M, Cuello AC. Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy. Neurobiology of Disease. PMID 30905766 DOI: 10.1016/j.nbd.2019.03.018   
2019 Goedert M, Falcon B, Zhang W, Ghetti B, Scheres SHW. Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases. Cold Spring Harbor Symposia On Quantitative Biology. PMID 30886056 DOI: 10.1101/sqb.2018.83.037580   
2019 Foiani MS, Cicognola C, Ermann N, Woollacott IOC, Heller C, Heslegrave AJ, Keshavan A, Paterson RW, Ye K, Kornhuber J, Fox NC, Schott JM, Warren JD, Lewczuk P, Zetterberg H, et al. Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 30981993 DOI: 10.1136/jnnp-2018-319266   
2019 Kumar H, Udgaonkar JB. Mechanistic approaches to understand the prion-like propagation of aggregates of the human tau protein. Biochimica Et Biophysica Acta. Proteins and Proteomics. PMID 30986567 DOI: 10.1016/j.bbapap.2019.04.004   
2019 Ali F, Josephs K. Rare Tauopathies. Seminars in Neurology. 39: 264-273. PMID 30925618 DOI: 10.1055/s-0039-1678584   
2019 Regalado-Reyes M, Furcila D, Hernández F, Ávila J, DeFelipe J, León-Espinosa G. Phospho-Tau Changes in the Human CA1 During Alzheimer's Disease Progression. Journal of Alzheimer's Disease : Jad. PMID 30958368 DOI: 10.3233/JAD-181263   
2019 Ding Y, Lei L, Lai C, Tang Z. Tau Protein and Zebrafish Models for Tau-Induced Neurodegeneration. Journal of Alzheimer's Disease : Jad. PMID 31006683 DOI: 10.3233/JAD-180917   
2019 Soe K, Beard H, Neumann D, Trim PJ, Duplock S, Snel MF, Hopwood JJ, Hemsley KM. Early disease course is unaltered in MPS IIIA mice lacking α-synuclein. Neuropathology and Applied Neurobiology. PMID 30907009 DOI: 10.1111/nan.12548   
2019 Nakayama S, Shimonaka S, Elahi M, Nishioka K, Oji Y, Matsumoto SE, Li Y, Yoshino H, Mogushi K, Hatano T, Sato T, Ikura T, Ito N, Motoi Y, Hattori N. Tau aggregation and seeding analyses of two novel MAPT variants found in patients with motor neuron disease and progressive parkinsonism. Neurobiology of Aging. PMID 31027853 DOI: 10.1016/j.neurobiolaging.2019.02.016   
2019 Bhattacharjee P, Öhrfelt A, Lashley T, Blennow K, Brinkmalm A, Zetterberg H. Mass spectrometric analysis of Lewy body-enriched α-synuclein in Parkinson's disease. Journal of Proteome Research. PMID 30943367 DOI: 10.1021/acs.jproteome.8b00982   
2019 Dobson CM, Knowles TPJ, Vendruscolo M. The Amyloid Phenomenon and Its Significance in Biology and Medicine. Cold Spring Harbor Perspectives in Biology. PMID 30936117 DOI: 10.1101/cshperspect.a033878   
2019 Vaquer-Alicea J, Diamond MI. Propagation of Protein Aggregation in Neurodegenerative Diseases. Annual Review of Biochemistry. PMID 30917002 DOI: 10.1146/annurev-biochem-061516-045049   
2019 Liu-Seifert H, Schumi J, Miao X, Tian Y, Rabbia M, Andersen SW, Wilson S, Li W, Entsuah R. Disease Modification in Alzheimer's Disease: Current Thinking. Therapeutic Innovation & Regulatory Science. 2168479019841894. PMID 30983382 DOI: 10.1177/2168479019841894   
2019 Soeda Y, Saito M, Maeda S, Ishida K, Nakamura A, Kojima S, Takashima A. Methylene Blue Inhibits Formation of Tau Fibrils but not of Granular Tau Oligomers: A Plausible Key to Understanding Failure of a Clinical Trial for Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 30909223 DOI: 10.3233/JAD-181001   
2019 Yu A, Fox SG, Cavallini A, Kerridge C, O'Neill MJ, Wolak J, Bose S, Morimoto RI. Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network. The Journal of Biological Chemistry. PMID 30936201 DOI: 10.1074/jbc.RA119.007527   
2019 Hansen D, Ling H, Lashley T, Holton JL, Warner TT. Clinical, neuropathological and genetic features of Lewy body dementias. Neuropathology and Applied Neurobiology. PMID 30977926 DOI: 10.1111/nan.12554   
2019 Can Akerman S, Hossain S, Shobo A, Zhong Y, Jourdain R, A Hancock M, George K, Breton L, Multhaup G. Neurodegenerative Disease-Related Proteins within the Epidermal Layer of the Human Skin. Journal of Alzheimer's Disease : Jad. PMID 31006686 DOI: 10.3233/JAD-181191   
2019 Kim SH, Yu MM, Strutt AM. Variably protease-sensitive prionopathy: A differential diagnostic consideration for dementia. Neurology. Clinical Practice. 9: 145-151. PMID 31041129 DOI: 10.1212/CPJ.0000000000000612   
2019 Jo M, Lee S, Kim K, Lee S, Kim SR, Kim HJ. Inhibition of MEK5 suppresses TDP-43 toxicity via the mTOR-independent activation of the autophagy-lysosome pathway. Biochemical and Biophysical Research Communications. PMID 31005259 DOI: 10.1016/j.bbrc.2019.04.088   
2019 Rencus-Lazar S, DeRowe Y, Adsi H, Gazit E, Laor D. Yeast Models for the Study of Amyloid-Associated Disorders and Development of Future Therapy. Frontiers in Molecular Biosciences. 6: 15. PMID 30968029 DOI: 10.3389/fmolb.2019.00015   
2019 Berson A, Goodman LD, Sartoris AN, Otte CG, Aykit JA, Lee VM, Trojanowski JQ, Bonini NM. Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies. Acta Neuropathologica Communications. 7: 65. PMID 31036086 DOI: 10.1186/s40478-019-0710-x   
2019 Kim YC, Jeong BH. In silico evaluation of acetylation mimics in the 27 lysine residues of human tau protein. Current Alzheimer Research. PMID 30907318 DOI: 10.2174/1567205016666190321161032   
2019 Zhang X, Liu RP, Cheng WH, Zhu JH. Prioritized Brain Selenium Retention and Selenoprotein Expression: Nutritional Insights into Parkinson's Disease. Mechanisms of Ageing and Development. PMID 30998939 DOI: 10.1016/j.mad.2019.04.004   
2019 Li S, Yin J, Nielsen M, Beach TG, Guo L, Shi J. Sirtuin 3 Mediates Tau Deacetylation. Journal of Alzheimer's Disease : Jad. PMID 30958373 DOI: 10.3233/JAD-190014   
2019 Benatar M, Turner MR, Wuu J. Defining pre-symptomatic amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-7. PMID 30892087 DOI: 10.1080/21678421.2019.1587634   
2019 Porter CK, Riddle MS, Gutierrez RL, Princen F, Strauss R, Telesco SE, Torres J, Choung RS, Laird RM, Leon F, Colombel JF, Murray JA, . Cohort profile of the PRoteomic Evaluation and Discovery in an IBD Cohort of Tri-service Subjects (PREDICTS) study: Rationale, organization, design, and baseline characteristics. Contemporary Clinical Trials Communications. 14: 100345. PMID 30989149 DOI: 10.1016/j.conctc.2019.100345   
2019 Andersson CR, Falsig J, Stavenhagen JB, Christensen S, Kartberg F, Rosenqvist N, Finsen B, Pedersen JT. Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes. Scientific Reports. 9: 4658. PMID 30874605 DOI: 10.1038/s41598-019-41105-4   
2019 Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ. Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 8. PMID 30907729 DOI: 10.7554/eLife.45457   
2019 Kim J, Selvaraji S, Wook Kang S, Thye Lee W, Li-Hsian Chen C, Choi H, Koo EH, Jo DG, Leong Lim K, Lim YA, Arumugam TV. Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice. Brain, Behavior, and Immunity. PMID 30980950 DOI: 10.1016/j.bbi.2019.04.011   
2019 Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, et al. A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy. Science Translational Medicine. 11. PMID 30918111 DOI: 10.1126/scitranslmed.aat3005   
2019 Tereshchenko A, Magnotta V, Epping E, Mathews K, Espe-Pfeifer P, Martin E, Dawson J, Duan W, Nopoulos P. Brain structure in juvenile-onset Huntington disease. Neurology. PMID 30971481 DOI: 10.1212/WNL.0000000000007355   
2019 Ho PW, Leung CT, Liu H, Pang SY, Lam CS, Xian J, Li L, Kung MH, Ramsden DB, Ho SL. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). Autophagy. 1-24. PMID 30983487 DOI: 10.1080/15548627.2019.1603545