Doron Shabat, Ph.D. - Publications

Affiliations: 
School of Chemistry Tel Aviv University, Tel Aviv-Yafo, Tel Aviv District, Israel 

78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Liubomirski Y, Tiram G, Scomparin A, Gnaim S, Das S, Gholap S, Ge L, Yeini E, Shelef O, Zauberman A, Berger N, Kalimi D, Toister-Achituv M, Schröter C, Dickgiesser S, ... ... Shabat D, et al. Potent antitumor activity of anti-HER2 antibody-topoisomerase I inhibitor conjugate based on self-immolative dendritic dimeric-linker. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 38228272 DOI: 10.1016/j.jconrel.2024.01.025  0.766
2022 Gnaim S, Gholap SP, Ge L, Das S, Gutkin S, Green O, Shelef O, Hananya N, Baran PS, Shabat D. Modular Access to Diverse Chemiluminescent Dioxetane-Luminophores Through Convergent Synthesis. Angewandte Chemie (International Ed. in English). PMID 35258138 DOI: 10.1002/anie.202202187  0.743
2021 Gholap SP, Yao C, Green O, Babjak M, Jakubec P, Malatinský T, Ihssen J, Wick L, Spitz U, Shabat D. Chemiluminescence Detection of Hydrogen Sulfide Release by β-Lactamase-Catalyzed β-Lactam Biodegradation: Unprecedented Pathway for Monitoring β-Lactam Antibiotic Bacterial Resistance. Bioconjugate Chemistry. PMID 33896185 DOI: 10.1021/acs.bioconjchem.1c00149  0.742
2020 Shabat D, Das S, Ihssen J, Wick L, Spitz U. Chemiluminescence Carbapenem-based Molecular Probe for Detection of Carbapenemase Activity in Live Bacteria. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31957167 DOI: 10.1002/Chem.202000217  0.683
2019 Gnaim S, Shabat D. Activity-Based Optical Sensing Enabled by Self-Immolative Scaffolds: Monitoring of Release Events by Fluorescence or Chemiluminescence Output. Accounts of Chemical Research. PMID 31483607 DOI: 10.1021/Acs.Accounts.9B00338  0.327
2019 Hananya N, Shabat D. Recent Advances and Challenges in Luminescent Imaging: Bright Outlook for Chemiluminescence of Dioxetanes in Water. Acs Central Science. 5: 949-959. PMID 31263754 DOI: 10.1021/Acscentsci.9B00372  0.314
2019 Hananya N, Reid JP, Green O, Sigman MS, Shabat D. Rapid chemiexcitation of phenoxy-dioxetane luminophores yields ultrasensitive chemiluminescence assays. Chemical Science. 10: 1380-1385. PMID 30809354 DOI: 10.1039/C8Sc04280B  0.322
2019 Gnaim S, Shabat D. Chemiluminescence molecular probe with a linear chain reaction amplification mechanism. Organic & Biomolecular Chemistry. PMID 30676601 DOI: 10.1039/C8Ob03042A  0.328
2018 Sun X, Shabat D, Phillips ST, Anslyn EV. Self-Propagating Amplification Reactions for Molecular Detection and Signal Amplification: Advantages, Pitfalls, and Challenges. Journal of Physical Organic Chemistry. 31. PMID 30386006 DOI: 10.1002/Poc.3827  0.327
2018 Shabat D, Gnaim S, Scomparin A, Das S, Satchi-Fainaro R. Real-Time Monitoring of Prodrug Activation by Direct-Mode of Chemiluminescence. Angewandte Chemie (International Ed. in English). PMID 29786931 DOI: 10.1002/Anie.201804816  0.686
2018 Bruemmer KJ, Green O, Su TA, Shabat D, Chang CJ. Chemiluminescent Probes for Activity-Based Sensing of Formaldehyde Released from Folate Degradation in Living Mice. Angewandte Chemie (International Ed. in English). PMID 29635731 DOI: 10.1002/Anie.201802143  0.325
2018 Eilon-Shaffer T, Roth-Konforti M, Eldar-Boock A, Satchi-Fainaro R, Shabat D. ortho-Chlorination of phenoxy 1,2-dioxetane yields superior chemiluminescent probes for in vitro and in vivo imaging. Organic & Biomolecular Chemistry. PMID 29451576 DOI: 10.1039/C8Ob00087E  0.336
2018 Gnaim S, Green O, Shabat D. The emergence of aqueous chemiluminescence: new promising class of phenoxy 1,2-dioxetane luminophores. Chemical Communications (Cambridge, England). PMID 29423487 DOI: 10.1039/C8Cc00428E  0.313
2017 Shabat D, Hananya N. A Glowing Trajectory between Bio- and Chemi-Luminescence: From Luciferin-based Probes to Triggerable Dioxetanes. Angewandte Chemie (International Ed. in English). PMID 28967167 DOI: 10.1002/Anie.201706969  0.303
2017 Green O, Gnaim S, Blau R, Eldar-Boock A, Satchi-Fainaro R, Shabat D. Near-Infrared Dioxetane Luminophores with Direct Chemiluminescence Emission Mode. Journal of the American Chemical Society. PMID 28853880 DOI: 10.1021/Jacs.7B08446  0.326
2017 Green O, Eilon T, Hananya N, Gutkin S, Bauer CR, Shabat D. Opening a Gateway for Chemiluminescence Cell Imaging: Distinctive Methodology for Design of Bright Chemiluminescent Dioxetane Probes. Acs Central Science. 3: 349-358. PMID 28470053 DOI: 10.1021/Acscentsci.7B00058  0.344
2016 Hananya N, Eldar Boock A, Bauer CR, Satchi-Fainaro R, Shabat D. Remarkable Enhancement of Chemiluminescent Signal by Dioxetane-Fluorophore Conjugates: Turn-ON Chemiluminescence Probes with Color Modulation for Sensing and Imaging. Journal of the American Chemical Society. PMID 27652602 DOI: 10.1021/Jacs.6B09173  0.318
2016 Gnaim S, Scomparin A, Li X, Baran PS, Rader C, Satchi-Fainaro R, Shabat D. Tagging the Untaggable: A Difluoroalkyl-Sulfinate Ketone-Based Reagent for Direct C-H Functionalization of Bioactive Heteroarenes. Bioconjugate Chemistry. PMID 27494153 DOI: 10.1021/Acs.Bioconjchem.6B00382  0.557
2016 Herbst E, Shabat D. FRET-based cyanine probes for monitoring ligation reactions and their applications to mechanistic studies and catalyst screening. Organic & Biomolecular Chemistry. 14: 3715-28. PMID 26909686 DOI: 10.1039/C5Ob02127H  0.354
2015 Redy-Keisar O, Ferber S, Satchi-Fainaro R, Shabat D. NIR Fluorogenic Dye as a Modular Platform for Prodrug Assembly: Real-Time in vivo Monitoring of Drug Release. Chemmedchem. 10: 999-1007. PMID 25847527 DOI: 10.1002/Cmdc.201500060  0.351
2014 Gnaim S, Shabat D. Quinone-methide species, a gateway to functional molecular systems: from self-immolative dendrimers to long-wavelength fluorescent dyes. Accounts of Chemical Research. 47: 2970-84. PMID 25181456 DOI: 10.1021/Ar500179Y  0.362
2014 Rader C, Segal DJ, Shabat D. Carlos F. Barbas III (1964-2014): Visionary at the interface of chemistry and biology. Acs Chemical Biology. 9: 1645-6. PMID 25123302 DOI: 10.1021/Cb5005993  0.568
2014 Kisin-Finfer E, Ferber S, Blau R, Satchi-Fainaro R, Shabat D. Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action. Bioorganic & Medicinal Chemistry Letters. 24: 2453-8. PMID 24767838 DOI: 10.1016/J.Bmcl.2014.04.022  0.32
2014 Ferber S, Baabur-Cohen H, Blau R, Epshtein Y, Kisin-Finfer E, Redy O, Shabat D, Satchi-Fainaro R. Polymeric nanotheranostics for real-time non-invasive optical imaging of breast cancer progression and drug release. Cancer Letters. 352: 81-9. PMID 24614283 DOI: 10.1016/J.Canlet.2014.02.022  0.326
2014 Redy-Keisar O, Kisin-Finfer E, Ferber S, Satchi-Fainaro R, Shabat D. Synthesis and use of QCy7-derived modular probes for the detection and imaging of biologically relevant analytes. Nature Protocols. 9: 27-36. PMID 24309975 DOI: 10.1038/Nprot.2013.166  0.328
2013 Sella E, Shabat D. Hydroquinone-quinone oxidation by molecular oxygen: a simple tool for signal amplification through auto-generation of hydrogen peroxide. Organic & Biomolecular Chemistry. 11: 5074-8. PMID 23824077 DOI: 10.1039/C3Ob40962G  0.321
2013 Kisin-Finfer E, Shabat D. New repertoire of 'donor-two-acceptor' NIR fluorogenic dyes. Bioorganic & Medicinal Chemistry. 21: 3602-8. PMID 23541837 DOI: 10.1016/J.Bmc.2013.02.049  0.302
2012 Karton-Lifshin N, Albertazzi L, Bendikov M, Baran PS, Shabat D. "Donor-two-acceptor" dye design: a distinct gateway to NIR fluorescence. Journal of the American Chemical Society. 134: 20412-20. PMID 23194283 DOI: 10.1021/Ja308124Q  0.314
2012 Redy O, Shabat D. Modular theranostic prodrug based on a FRET-activated self-immolative linker. Journal of Controlled Release : Official Journal of the Controlled Release Society. 164: 276-82. PMID 22580227 DOI: 10.1016/J.Jconrel.2012.05.009  0.351
2012 Redy O, Kisin-Finfer E, Sella E, Shabat D. A simple FRET-based modular design for diagnostic probes. Organic & Biomolecular Chemistry. 10: 710-5. PMID 22159494 DOI: 10.1039/C1Ob06667F  0.335
2011 Perry-Feigenbaum R, Sella E, Shabat D. Autoinductive exponential signal amplification: a diagnostic probe for direct detection of fluoride. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 12123-8. PMID 21905139 DOI: 10.1002/Chem.201101796  0.327
2011 Karton-Lifshin N, Segal E, Omer L, Portnoy M, Satchi-Fainaro R, Shabat D. A unique paradigm for a Turn-ON near-infrared cyanine-based probe: noninvasive intravital optical imaging of hydrogen peroxide. Journal of the American Chemical Society. 133: 10960-5. PMID 21631116 DOI: 10.1021/Ja203145V  0.345
2010 Sella E, Weinstain R, Erez R, Burns NZ, Baran PS, Shabat D. Sulfhydryl-based dendritic chain reaction. Chemical Communications (Cambridge, England). 46: 6575-7. PMID 20714571 DOI: 10.1039/C0Cc02195D  0.305
2010 Avital-Shmilovici M, Shabat D. Dendritic chain reaction: responsive release of hydrogen peroxide upon generation and enzymatic oxidation of methanol. Bioorganic & Medicinal Chemistry. 18: 3643-7. PMID 20231097 DOI: 10.1016/J.Bmc.2010.02.038  0.318
2010 Sella E, Lubelski A, Klafter J, Shabat D. Two-component dendritic chain reactions: experiment and theory. Journal of the American Chemical Society. 132: 3945-52. PMID 20192194 DOI: 10.1021/Ja910839N  0.311
2010 Avital-Shmilovici M, Shabat D. Self-immolative dendrimers: A distinctive approach to molecular amplification Soft Matter. 6: 1073-1080. DOI: 10.1039/B922341J  0.337
2010 Keinan E, Shabat D, Carmeli S. The 75th annual meeting of the Israel Chemical Society, Tel Aviv, David intercontinental hotel, january 25-26, 2010 Israel Journal of Chemistry. 50: 255-261. DOI: 10.1002/Ijch.201000050  0.454
2009 Perry-Feigenbaum R, Baran PS, Shabat D. The pyridinone-methide elimination. Organic & Biomolecular Chemistry. 7: 4825-8. PMID 19907770 DOI: 10.1039/B915265B  0.325
2009 Weinstain R, Baran PS, Shabat D. Activity-linked labeling of enzymes by self-immolative polymers. Bioconjugate Chemistry. 20: 1783-91. PMID 19689155 DOI: 10.1021/Bc9002037  0.301
2009 Sella E, Shabat D. Dendritic chain reaction. Journal of the American Chemical Society. 131: 9934-6. PMID 19569684 DOI: 10.1021/Ja903032T  0.3
2009 Stern L, Perry R, Ofek P, Many A, Shabat D, Satchi-Fainaro R. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjugate Chemistry. 20: 500-10. PMID 19196156 DOI: 10.1021/Bc800448U  0.305
2008 Erez R, Ebner S, Attali B, Shabat D. Chemotherapeutic bone-targeted bisphosphonate prodrugs with hydrolytic mode of activation. Bioorganic & Medicinal Chemistry Letters. 18: 816-20. PMID 18061452 DOI: 10.1016/J.Bmcl.2007.11.029  0.305
2007 Danieli E, Shabat D. Molecular probe for enzymatic activity with dual output. Bioorganic & Medicinal Chemistry. 15: 7318-24. PMID 17869526 DOI: 10.1016/J.Bmc.2007.08.046  0.326
2007 Shamis M, Shabat D. Single-triggered AB6 self-immolative dendritic amplifiers. Chemistry (Weinheim An Der Bergstrasse, Germany). 13: 4523-8. PMID 17477455 DOI: 10.1002/Chem.200700142  0.335
2007 Sagi A, Segal E, Satchi-Fainaro R, Shabat D. Remarkable drug-release enhancement with an elimination-based AB3 self-immolative dendritic amplifier. Bioorganic & Medicinal Chemistry. 15: 3720-7. PMID 17416532 DOI: 10.1016/J.Bmc.2007.03.054  0.357
2007 Shamis M, Barbas CF, Shabat D. A new visual screening assay for catalytic antibodies with retro-aldol retro-Michael activity. Bioorganic & Medicinal Chemistry Letters. 17: 1172-5. PMID 17234408 DOI: 10.1016/J.Bmcl.2006.12.057  0.362
2007 Amir RJ, Danieli E, Shabat D. Receiver-amplifier, self-immolative dendritic device. Chemistry (Weinheim An Der Bergstrasse, Germany). 13: 812-21. PMID 17075925 DOI: 10.1002/Chem.200601263  0.304
2006 Gopin A, Ebner S, Attali B, Shabat D. Enzymatic activation of second-generation dendritic prodrugs: Conjugation of self-immolative dendrimers with poly(ethylene glycol) via click chemistry. Bioconjugate Chemistry. 17: 1432-40. PMID 17105221 DOI: 10.1021/Bc060180N  0.341
2006 Sagi A, Rishpon J, Shabat D. Amperometric assay for aldolase activity: antibody-catalyzed ferrocenylamine formation. Analytical Chemistry. 78: 1459-61. PMID 16503594 DOI: 10.1021/Ac0517141  0.389
2006 Weinstein R, Lerner RA, Barbas CF, Shabat D. Antibody-Catalyzed Asymmetric Intramolecular Michael Reaction Synfacts. 2006: 71-71. DOI: 10.1055/S-2005-921711  0.38
2006 Shabat D. Self-immolative dendrimers as novel drug delivery platforms Journal of Polymer Science, Part a: Polymer Chemistry. 44: 1569-1578. DOI: 10.1002/Pola.21258  0.335
2005 Weinstain R, Lerner RA, Barbas CF, Shabat D. Antibody-catalyzed asymmetric intramolecular Michael addition of aldehydes and ketones to yield the disfavored cis-product. Journal of the American Chemical Society. 127: 13104-5. PMID 16173712 DOI: 10.1021/Ja0536825  0.548
2005 Amir RJ, Popkov M, Lerner RA, Barbas CF, Shabat D. Prodrug activation gated by a molecular "OR" logic trigger. Angewandte Chemie (International Ed. in English). 44: 4378-81. PMID 15942963 DOI: 10.1002/Anie.200500842  0.453
2005 Haba K, Popkov M, Shamis M, Lerner RA, Barbas CF, Shabat D. Single-triggered trimeric prodrugs. Angewandte Chemie (International Ed. in English). 44: 716-20. PMID 15657968 DOI: 10.1002/Anie.200461657  0.447
2004 Shabat D, Amir RJ, Gopin A, Pessah N, Shamis M. Chemical adaptor systems. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 2626-34. PMID 15195294 DOI: 10.1002/Chem.200305715  0.357
2004 Pessah N, Reznik M, Shamis M, Yantiri F, Xin H, Bowdish K, Shomron N, Ast G, Shabat D. Bioactivation of carbamate-based 20(S)-camptothecin prodrugs. Bioorganic & Medicinal Chemistry. 12: 1859-66. PMID 15051055 DOI: 10.1016/J.Bmc.2004.01.039  0.394
2004 Gopin A, Rader C, Shabat D. New chemical adaptor unit designed to release a drug from a tumor targeting device by enzymatic triggering. Bioorganic & Medicinal Chemistry. 12: 1853-8. PMID 15051054 DOI: 10.1016/J.Bmc.2004.01.041  0.523
2004 Shamis M, Lode HN, Shabat D. Bioactivation of self-immolative dendritic prodrugs by catalytic antibody 38C2. Journal of the American Chemical Society. 126: 1726-31. PMID 14871103 DOI: 10.1021/Ja039052P  0.385
2003 Rader C, Turner JM, Heine A, Shabat D, Sinha SC, Wilson IA, Lerner RA, Barbas CF. A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy. Journal of Molecular Biology. 332: 889-99. PMID 12972259 DOI: 10.1016/S0022-2836(03)00992-6  0.646
2003 Jikai J, Shamis M, Huebener N, Schroeder U, Wrasidlo W, Wenkel J, Lange B, Gaedicke G, Shabat D, Lode HN. Neuroblastoma directed therapy by a rational prodrug design of etoposide as a substrate for tyrosine hydroxylase. Cancer Letters. 197: 219-24. PMID 12880985 DOI: 10.1016/S0304-3835(03)00104-6  0.315
2003 Gopin A, Pessah N, Shamis M, Rader C, Shabat D. A chemical adaptor system designed to link a tumor-targeting device with a prodrug and an enzymatic trigger. Angewandte Chemie (International Ed. in English). 42: 327-32. PMID 12548691 DOI: 10.1002/Anie.200390108  0.482
2002 Satchi-Fainaro R, Wrasidlo W, Lode HN, Shabat D. Synthesis and characterization of a catalytic antibody-HPMA copolymer-Conjugate as a tool for tumor selective prodrug activation. Bioorganic & Medicinal Chemistry. 10: 3023-9. PMID 12110325 DOI: 10.1016/S0968-0896(02)00156-6  0.403
2001 Shabat D, Lode HN, Pertl U, Reisfeld RA, Rader C, Lerner RA, Barbas CF. In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy. Proceedings of the National Academy of Sciences of the United States of America. 98: 7528-33. PMID 11404472 DOI: 10.1073/Pnas.131187998  0.659
1999 Shabat D, Rader C, List B, Lerner RA, Barbas CF. Multiple event activation of a generic prodrug trigger by antibody catalysis. Proceedings of the National Academy of Sciences of the United States of America. 96: 6925-30. PMID 10359815 DOI: 10.1073/Pnas.96.12.6925  0.698
1999 List B, Shabat D, Zhong G, Turner JM, Li A, Bui T, Anderson J, Lerner RA, Barbas CF. A catalytic enantioselective route to hydroxy-substituted quaternary carbon centers: Resolution of tertiary aldols with a catalytic antibody Journal of the American Chemical Society. 121: 7283-7291. DOI: 10.1021/Ja991507G  0.687
1999 Shulman A, Keinan E, Shabat D, Barbas CF. Teaching Catalytic Antibodies to Undergraduate Students: An Organic Chemistry Lab Experiment Journal of Chemical Education. 76: 977-982. DOI: 10.1021/Ed076P977  0.586
1999 Shabat D, List B, Lerner RA, Barbas CF. A short enantioselective synthesis of 1-deoxy-L-xylulose by antibody catalysis Tetrahedron Letters. 40: 1437-1440. DOI: 10.1016/S0040-4039(98)02699-9  0.587
1998 Zhong G, Shabat D, List B, Anderson J, Sinha SC, Lerner RA, Barbas Iii CF. Catalytic Enantioselective Retro-Aldol Reactions: Kinetic Resolution of β-Hydroxyketones with Aldolase Antibodies. Angewandte Chemie (International Ed. in English). 37: 2481-2484. PMID 29711357 DOI: 10.1002/(Sici)1521-3773(19981002)37:18<2481::Aid-Anie2481>3.0.Co;2-T  0.684
1998 Shabat D, Shulman H, Itzhaky H, Raymond JL, Keinan E. Enantioselectivity vs. kinetic resolution in antibody catalysis: Formation of the (S) product despite preferential binding of the (R) intermediate Chemical Communications. 1759-1760. DOI: 10.1039/A802374C  0.537
1998 Hoffmann T, Zhong G, List B, Shabat D, Anderson J, Gramatikova S, Lerner RA, Barbas CF. Aldolase antibodies of remarkable scope Journal of the American Chemical Society. 120: 2768-2779. DOI: 10.1021/Ja973676B  0.68
1998 Zhong G, Shabat D, List B, Anderson J, Sinha SC, Lerner RA, Barbas CF. Catalytic enantioselective retro-aldol reactions: Kinetic resolution of β-hydroxyketones with aldolase antibodies Angewandte Chemie - International Edition. 37: 2481-2484. DOI: 10.1002/(SICI)1521-3773(19981002)37:18<2481::AID-ANIE2481>3.0.CO;2-T  0.607
1998 List B, Shabat D, Barbas CF, Lerner RA. Enantioselective total synthesis of some brevicomins using aldolase antibody 38C2 Chemistry - a European Journal. 4: 881-885. DOI: 10.1002/(Sici)1521-3765(19980515)4:5<881::Aid-Chem881>3.0.Co;2-#  0.605
1998 Zhong G, Shabat D, List B, Anderson J, Sinha SC, Lerner RA, Barbas CF. Katalytische enantioselektive Retro-Aldolreaktion: kinetische Racematspaltung von β-Hydroxyketonen durch Aldolase-Antikörper Angewandte Chemie. 110: 2609-2612. DOI: 10.1002/(Sici)1521-3757(19980918)110:18<2609::Aid-Ange2609>3.0.Co;2-E  0.618
1997 Shabat D, Grynszpan F, Saphier S, Turniansky A, Avnir D, Keinan E. An Efficient Sol - Gel Reactor for Antibody-Catalyzed Transformations Chemistry of Materials. 9: 2258-2260. DOI: 10.1021/Cm970193Y  0.737
1996 Ghosh P, Shabat D, Kumar S, Sinha SC, Grynszpan F, Li J, Noodleman L, Keinan E. Using antibodies to perturb the coordination sphere of a transition metal complex. Nature. 382: 339-41. PMID 8684461 DOI: 10.1038/382339A0  0.697
1996 Shabat D, Sinha SC, Reymond JL, Keinan E. Catalytic antibodies as probes of evolution: Modeling of a primordial glycosidase Angewandte Chemie - International Edition in English. 35: 2628-2630. DOI: 10.1002/Anie.199626281  0.584
1996 Shabat D, Sinha SC, Reymond J, Keinan E. Katalytische Antikörper als Sonden für die Evolution von Enzymen: Modellierung einer frühen Glycosidase Angewandte Chemie. 108: 2800-2802. DOI: 10.1002/Ange.19961082212  0.458
1995 Shabat D, Itzhaky H, Reymond JL, Keinan E. Antibody catalysis of a reaction otherwise strongly disfavoured in water. Nature. 374: 143-6. PMID 7877686 DOI: 10.1038/374143A0  0.588
Show low-probability matches.