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Emmanuel Darcq - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 
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62/65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Sourty M, Champagnol-Di Liberti C, Nasseef MT, Welsch L, Noblet V, Darcq E, Kieffer BL. Chronic morphine leaves a durable fingerprint on whole brain functional connectivity. Biological Psychiatry. PMID 38104648 DOI: 10.1016/j.biopsych.2023.12.007  0.12
2023 Sourty M, Nasseef MT, Champagnol-Di Liberti C, Mondino M, Noblet V, Parise EM, Markovic T, Browne CJ, Darcq E, Nestler EJ, Kieffer BL. Manipulating ΔFOSB in D1-type Medium Spiny Neurons of the nucleus accumbens reshapes whole brain functional connectivity. Biological Psychiatry. PMID 37517704 DOI: 10.1016/j.biopsych.2023.07.013  0.78
2023 Welsch L, Colantonio E, Falconnier C, Champagnol-DiLiberti C, Allain F, Ben Hamida S, Darcq E, Lutz PE, Kieffer BL. Mu opioid receptor-positive neurons in the dorsal raphe nucleus are impaired by morphine abstinence. Biological Psychiatry. PMID 37393045 DOI: 10.1016/j.biopsych.2023.06.024  0.707
2023 Allain F, Ehrlich AT, McNicholas M, Gross F, Ma W, Kieffer BL, Darcq E. Chronic tianeptine induces tolerance in analgesia and hyperlocomotion via mu-opioid receptor activation in mice. Frontiers in Psychiatry. 14: 1186397. PMID 37287667 DOI: 10.3389/fpsyt.2023.1186397  0.589
2023 Welsch L, Colantonio E, Frison M, Johnson DA, McClain SP, Mathis V, Banghart MR, Ben Hamida S, Darcq E, Kieffer BL. Mu opioid receptors-expressing neurons in the dorsal raphe nucleus are involved in reward processing and affective behaviors. Biological Psychiatry. PMID 37285896 DOI: 10.1016/j.biopsych.2023.05.019  0.58
2023 Ozdemir D, Allain F, Kieffer BL, Darcq E. Advances in the characterization of negative affect caused by acute and protracted opioid withdrawal using animal models. Neuropharmacology. 232: 109524. PMID 37003572 DOI: 10.1016/j.neuropharm.2023.109524  0.555
2023 Wang W, Xie X, Zhuang X, Huang Y, Tan T, Gangal H, Huang Z, Purvines W, Wang X, Stefanov A, Chen R, Rodriggs L, Chaiprasert A, Yu E, Vierkant V, ... ... Darcq E, et al. Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect. Cell Reports. 112089. PMID 36796365 DOI: 10.1016/j.celrep.2023.112089  0.355
2023 Rahman MT, Decker AM, Ben Hamida S, Perrey DA, Chaminda Lakmal HH, Maitra R, Darcq E, Kieffer BL, Jin C. Improvement of the Metabolic Stability of GPR88 Agonist RTI-13951-33: Design, Synthesis, and Biological Evaluation. Journal of Medicinal Chemistry. PMID 36749855 DOI: 10.1021/acs.jmedchem.2c01983  0.554
2022 Decker AM, Rahman MT, Kormos CM, Hesk D, Darcq E, Kieffer BL, Jin C. Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor. Bioorganic & Medicinal Chemistry Letters. 80: 129120. PMID 36587872 DOI: 10.1016/j.bmcl.2022.129120  0.479
2022 Bailly J, Allain F, Schwartz E, Tirel C, Dupuy C, Petit F, Diana MA, Darcq E, Kieffer BL. Habenular Neurons Expressing Mu Opioid Receptors Promote Negative Affect in a Projection-Specific Manner. Biological Psychiatry. PMID 36496267 DOI: 10.1016/j.biopsych.2022.09.013  0.583
2022 Darcq E, Nouel D, Hernandez G, Pokinko M, Ash P, Moquin L, Gratton A, Kieffer B, Flores C. Reduced dopamine release in Dcc haploinsufficiency male mice abolishes the rewarding effects of cocaine but not those of morphine and ethanol. Psychopharmacology. PMID 36471064 DOI: 10.1007/s00213-022-06288-1  0.494
2022 Allain F, Carter M, Dumas S, Darcq E, Kieffer BL. The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula. Scientific Reports. 12: 20234. PMID 36424418 DOI: 10.1038/s41598-022-24395-z  0.556
2022 Ben Hamida S, Carter M, Darcq E, Sourty M, Rahman MT, Decker AM, Jin C, Kieffer BL. The GPR88 agonist RTI-13951-33 reduces alcohol drinking and seeking in mice. Addiction Biology. 27: e13227. PMID 36301207 DOI: 10.1111/adb.13227  0.541
2022 Ben Hamida S, Sengupta SM, Clarke E, McNicholas M, Moroncini E, Darcq E, Ter-Stepanian M, Fortier MÈ, Grizenko N, Joober R, Kieffer BL. The orphan receptor GPR88 controls impulsivity and is a risk factor for Attention-Deficit/Hyperactivity Disorder. Molecular Psychiatry. PMID 36075963 DOI: 10.1038/s41380-022-01738-w  0.532
2022 Posa L, De Gregorio D, He Q, Lopez-Canul M, Darcq E, Rullo L, Pearl-Dowler L, Luongo L, Candeletti S, Romualdi P, Kieffer BL, Gobbi G. Supraspinal melatonin MT receptor agonism alleviates pain via a neural circuit that recruits mu opioid receptors. Journal of Pineal Research. PMID 35996205 DOI: 10.1111/jpi.12825  0.788
2021 Ehrlich AT, Semache M, Couvineau P, Wojcik S, Kobayashi H, Thelen M, Gross F, Hogue M, Le Gouill C, Darcq E, Bouvier M, Kieffer BL. Ackr3-Venus knock-in mouse lights up brain vasculature. Molecular Brain. 14: 151. PMID 34583741 DOI: 10.1186/s13041-021-00862-y  0.563
2021 Rahman MT, Decker AM, Laudermilk L, Maitra R, Ma W, Ben Hamida S, Darcq E, Kieffer BL, Jin C. Evaluation of Amide Bioisosteres Leading to 1,2,3-Triazole Containing Compounds as GPR88 Agonists: Design, Synthesis, and Structure-Activity Relationship Studies. Journal of Medicinal Chemistry. PMID 34387471 DOI: 10.1021/acs.jmedchem.1c01075  0.521
2021 Ehrlich AT, Darcq E. Recent advances in basic science methodology to evaluate opioid safety profiles and to understand opioid activities. Faculty Reviews. 10: 15. PMID 33718932 DOI: 10.12703/r/10-15  0.326
2021 Nasseef MT, Ma W, Singh JP, Dozono N, Lançon K, Séguéla P, Darcq E, Ueda H, Kieffer BL. Chronic generalized pain disrupts whole brain functional connectivity in mice. Brain Imaging and Behavior. PMID 33428113 DOI: 10.1007/s11682-020-00438-9  0.76
2020 Rahman MT, Decker AM, Langston TL, Mathews KM, Laudermilk L, Maitra R, Ma W, Darcq E, Kieffer BL, Jin C. Design, Synthesis, and Structure-Activity Relationship Studies of (4-Alkoxyphenyl)glycinamides and Bioisosteric 1,3,4-Oxadiazoles as GPR88 Agonists. Journal of Medicinal Chemistry. PMID 33205975 DOI: 10.1021/acs.jmedchem.0c01581  0.521
2020 Bailly J, Del Rossi N, Runtz L, Li JJ, Park D, Scherrer G, Tanti A, Birling MC, Darcq E, Kieffer BL. Targeting morphine-responsive neurons: generation of a knock-in mouse line expressing Cre recombinase from the mu opioid receptor gene locus. Eneuro. PMID 32381649 DOI: 10.1523/ENEURO.0433-19.2020  0.764
2020 Neasta J, Darcq E, Jeanblanc J, Carnicella S, Ben Hamida S. GPCR and Alcohol-Related Behaviors in Genetically Modified Mice. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 31919661 DOI: 10.1007/S13311-019-00828-Y  0.779
2019 Nasseef MT, Singh JP, Ehrlich AT, McNicholas M, Park DW, Ma W, Kulkarni P, Kieffer BL, Darcq E. Oxycodone-Mediated Activation of the Mu Opioid Receptor Reduces Whole Brain Functional Connectivity in Mice. Acs Pharmacology & Translational Science. 2: 264-274. PMID 32259060 DOI: 10.1021/acsptsci.9b00021  0.808
2019 Welsch L, Bailly J, Darcq E, Kieffer BL. The Negative Affect of Protracted Opioid Abstinence: Progress and Perspectives From Rodent Models. Biological Psychiatry. PMID 31521334 DOI: 10.1016/J.Biopsych.2019.07.027  0.652
2019 Boulos LJ, Ben Hamida S, Bailly J, Maitra M, Ehrlich AT, Gavériaux-Ruff C, Darcq E, Kieffer BL. Mu opioid receptors in the medial habenula contribute to naloxone aversion. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31005059 DOI: 10.1038/S41386-019-0395-7  0.682
2019 Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL. Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons. Iscience. 14: 47-57. PMID 30925410 DOI: 10.1016/J.Isci.2019.03.011  0.632
2019 Boulos LJ, Nasseef MT, McNicholas M, Mechling A, Harsan LA, Darcq E, Ben Hamida S, Kieffer BL. TouchScreen-based phenotyping: altered stimulus/reward association and lower perseveration to gain a reward in mu opioid receptor knockout mice. Scientific Reports. 9: 4044. PMID 30858487 DOI: 10.1038/S41598-019-40622-6  0.792
2019 Ehrlich AT, Kieffer BL, Darcq E. Current strategies toward safer mu opioid receptor drugs for pain management. Expert Opinion On Therapeutic Targets. PMID 30802415 DOI: 10.1080/14728222.2019.1586882  0.628
2019 Ehrlich AT, Darcq E. Recommending buprenorphine for pain management. Pain Management. 9: 13-16. PMID 30507294 DOI: 10.2217/Pmt-2018-0069  0.251
2018 Nasseef MT, Devenyi GA, Mechling AE, Harsan LA, Chakravarty MM, Kieffer BL, Darcq E. Deformation-based Morphometry MRI Reveals Brain Structural Modifications in Living Mu Opioid Receptor Knockout Mice. Frontiers in Psychiatry. 9: 643. PMID 30559685 DOI: 10.3389/Fpsyt.2018.00643  0.801
2018 Ehrlich AT, Maroteaux G, Robe A, Venteo L, Nasseef MT, van Kempen LC, Mechawar N, Turecki G, Darcq E, Kieffer BL. Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research. Communications Biology. 1: 102. PMID 30271982 DOI: 10.1038/s42003-018-0106-7  0.761
2018 Jin C, Decker AM, Makhijani VH, Besheer J, Darcq E, Kieffer BL, Maitra R. Discovery of a Potent, Selective, and Brain-Penetrant Small-Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake. Journal of Medicinal Chemistry. PMID 30011199 DOI: 10.1021/Acs.Jmedchem.8B00566  0.605
2018 Darcq E, Kieffer BL. Opioid receptors: drivers to addiction? Nature Reviews. Neuroscience. PMID 29934561 DOI: 10.1038/S41583-018-0028-X  0.636
2018 Darcq E, Kieffer BL. The Control of Reward Seeking. Biological Psychiatry. 83: 981-983. PMID 29804588 DOI: 10.1016/J.Biopsych.2018.04.003  0.492
2018 Ben Hamida S, Mendonça-Netto S, Arefin TM, Nasseef MT, Boulos LJ, McNicholas M, Ehrlich AT, Clarke E, Moquin L, Gratton A, Darcq E, Harsan LA, Maldonado R, Kieffer BL. Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks. Biological Psychiatry. PMID 29580570 DOI: 10.1016/J.Biopsych.2018.01.026  0.783
2018 Maroteaux G, Arefin TM, Harsan LA, Darcq E, Ben Hamida S, Kieffer BL. Lack of anticipatory behavior in Gpr88 knockout mice showed by automatized home cage phenotyping. Genes, Brain, and Behavior. e12473. PMID 29575471 DOI: 10.1111/Gbb.12473  0.559
2017 Cruceanu C, Schmouth JF, Torres-Platas SG, Lopez JP, Ambalavanan A, Darcq E, Gross F, Breton B, Spiegelman D, Rochefort D, Hince P, Petite JM, Gauthier J, Lafrenière RG, Dion PA, et al. Rare susceptibility variants for bipolar disorder suggest a role for G protein-coupled receptors. Molecular Psychiatry. PMID 29158579 DOI: 10.1038/mp.2017.223  0.467
2017 Ehrlich AT, Semache M, Bailly J, Wojcik S, Arefin TM, Colley C, Le Gouill C, Gross F, Lukasheva V, Hogue M, Darcq E, Harsan LA, Bouvier M, Kieffer BL. Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing. Brain Structure & Function. PMID 29110094 DOI: 10.1007/S00429-017-1547-3  0.606
2017 Phamluong K, Darcq E, Wu S, Sakhai SA, Ron D. Fyn Signaling Is Compartmentalized to Dopamine D1 Receptor Expressing Neurons in the Dorsal Medial Striatum. Frontiers in Molecular Neuroscience. 10: 273. PMID 28912680 DOI: 10.3389/Fnmol.2017.00273  0.554
2017 Boulos LJ, Darcq E, Kieffer BL. Translating the Habenula-From Rodents to Humans. Biological Psychiatry. 81: 296-305. PMID 27527822 DOI: 10.1016/J.Biopsych.2016.06.003  0.566
2016 Charbogne P, Gardon O, Martín-García E, Keyworth HL, Matsui A, Mechling AE, Bienert T, Nasseef T, Robé A, Moquin L, Darcq E, Ben Hamida S, Robledo P, Matifas A, Befort K, et al. Mu Opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food. Biological Psychiatry. PMID 28185645 DOI: 10.1016/J.Biopsych.2016.12.022  0.646
2016 Moore K, Madularu D, Iriah S, Yee JR, Kulkarni P, Darcq E, Kieffer BL, Ferris CF. BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone. Frontiers in Neuroscience. 10: 471. PMID 27857679 DOI: 10.3389/Fnins.2016.00471  0.659
2016 Darcq E, Morisot N, Phamluong K, Warnault V, Jeanblanc J, Longo FM, Massa SM, Ron D. The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10116-27. PMID 27683907 DOI: 10.1523/Jneurosci.4597-14.2016  0.701
2016 Mechling AE, Arefin T, Lee HL, Bienert T, Reisert M, Ben Hamida S, Darcq E, Ehrlich A, Gaveriaux-Ruff C, Parent MJ, Rosa-Neto P, Hennig J, von Elverfeldt D, Kieffer BL, Harsan LA. Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome. Proceedings of the National Academy of Sciences of the United States of America. PMID 27671662 DOI: 10.1073/Pnas.1601640113  0.649
2015 Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D. The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice that Is Reversed by Tropomyosin Receptor Kinase B Activation. Biological Psychiatry. PMID 26204799 DOI: 10.1016/J.Biopsych.2015.06.007  0.543
2015 Legastelois R, Darcq E, Wegner SA, Lombroso PJ, Ron D. Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking. Plos One. 10: e0127408. PMID 25992601 DOI: 10.1371/Journal.Pone.0127408  0.56
2015 Darcq E, Kieffer BL. PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research. Embo Molecular Medicine. 7: 859-61. PMID 25925427 DOI: 10.15252/Emmm.201505266  0.531
2015 Chung PC, Boehrer A, Stephan A, Matifas A, Scherrer G, Darcq E, Befort K, Kieffer BL. Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures. Behavioural Brain Research. 278: 429-34. PMID 25447299 DOI: 10.1016/J.Bbr.2014.10.029  0.74
2015 Chu Sin Chung P, Keyworth HL, Martin-Garcia E, Charbogne P, Darcq E, Bailey A, Filliol D, Matifas A, Scherrer G, Ouagazzal AM, Gaveriaux-Ruff C, Befort K, Maldonado R, Kitchen I, Kieffer BL. A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons. Biological Psychiatry. 77: 404-15. PMID 25444168 DOI: 10.1016/J.Biopsych.2014.07.033  0.763
2015 Darcq E, Kieffer BL. PI3K signaling in the locus coeruleus: A new molecular pathway for ADHD research Embo Molecular Medicine. 7: 859-861. DOI: 10.15252/emmm.201505266  0.397
2014 Darcq E, Warnault V, Phamluong K, Besserer GM, Liu F, Ron D. MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption. Molecular Psychiatry. PMID 25385365 DOI: 10.1038/Mp.2014.155  0.477
2014 Darcq E, Warnault V, Phamluong K, Besserer GM, Liu F, Ron D. MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption. Molecular Psychiatry. PMID 25330738 DOI: 10.1038/mp.2014.120  0.411
2014 Darcq E, Hamida SB, Wu S, Phamluong K, Kharazia V, Xu J, Lombroso P, Ron D. Inhibition of striatal-enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption. Journal of Neurochemistry. 129: 1024-34. PMID 24588427 DOI: 10.1111/Jnc.12701  0.496
2013 Ben Hamida S, Darcq E, Wang J, Wu S, Phamluong K, Kharazia V, Ron D. Protein tyrosine phosphatase α in the dorsomedial striatum promotes excessive ethanol-drinking behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 14369-78. PMID 24005290 DOI: 10.1523/Jneurosci.1954-13.2013  0.5
2013 Warnault V, Darcq E, Levine A, Barak S, Ron D. Chromatin remodeling--a novel strategy to control excessive alcohol drinking. Translational Psychiatry. 3: e231. PMID 23423140 DOI: 10.1038/Tp.2013.4  0.625
2012 Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb SL, Lanfranco MF, Carnicella S, Ron D. Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15124-32. PMID 23100433 DOI: 10.1523/Jneurosci.2783-12.2012  0.713
2012 Darcq E, Befort K, Koebel P, Pannetier S, Mahoney MK, Gaveriaux-Ruff C, Hanauer A, Kieffer BL. RSK2 signaling in medial habenula contributes to acute morphine analgesia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1288-96. PMID 22218090 DOI: 10.1038/Npp.2011.316  0.623
2012 Le Merrer J, Befort K, Gardon O, Filliol D, Darcq E, Dembele D, Becker JA, Kieffer BL. Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network. Addiction Biology. 17: 1-12. PMID 21955143 DOI: 10.1111/J.1369-1600.2011.00365.X  0.592
2011 Darcq E, Koebel P, Del Boca C, Pannetier S, Kirstetter AS, Garnier JM, Hanauer A, Befort K, Kieffer BL. RSK2 signaling in brain habenula contributes to place aversion learning. Learning & Memory (Cold Spring Harbor, N.Y.). 18: 574-8. PMID 21852432 DOI: 10.1101/Lm.2221011  0.527
2011 Goeldner C, Lutz PE, Darcq E, Halter T, Clesse D, Ouagazzal AM, Kieffer BL. Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine. Biological Psychiatry. 69: 236-44. PMID 20947067 DOI: 10.1016/J.Biopsych.2010.08.021  0.699
2008 Befort K, Filliol D, Darcq E, Ghate A, Matifas A, Lardenois A, Muller J, Thibault C, Dembele D, Poch O, Kieffer BL. Gene expression is altered in the lateral hypothalamus upon activation of the mu opioid receptor. Annals of the New York Academy of Sciences. 1129: 175-84. PMID 18591478 DOI: 10.1196/Annals.1417.028  0.651
2008 Befort K, Filliol D, Ghate A, Darcq E, Matifas A, Muller J, Lardenois A, Thibault C, Dembele D, Le Merrer J, Becker JA, Poch O, Kieffer BL. Mu-opioid receptor activation induces transcriptional plasticity in the central extended amygdala. The European Journal of Neuroscience. 27: 2973-84. PMID 18588537 DOI: 10.1111/J.1460-9568.2008.06273.X  0.66
Low-probability matches (unlikely to be authored by this person)
2004 Giolitto J, Devoldere G, Darcq E, Tournant G, Fendler J. 311 Stress urinary incontinence treatment using a sub urethral support. Results at 1 year from a multicentre prospective study European Urology Supplements. 3: 80. DOI: 10.1016/S1569-9056(04)90310-7  0.02
1975 Colas JM, Paoletti G, Darcq E, Bittard M. [Renal arteriovenous fistual of neoplastic origin]. Journal D'Urologie Et De Nephrologie. 81: 423-8. PMID 1152136  0.01
1975 Colas JM, Dupond JL, Saint-Hillier Y, Darcq E, Bittard M. [Urinary lithiasis and parathyroid adenoma]. Journal D'Urologie Et De Nephrologie. 81: 419-23. PMID 1152135  0.01
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