Lorenzo Leggio - Publications

Affiliations: 
NIAAA, Indianapolis, IN, United States 

177 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Singal AK, DiMartini A, Leggio L, Arab JP, Kuo YF, Shah VH. Identifying Alcohol Use Disorder in Patients With Cirrhosis Reduces 30-Days Readmission Rate. Alcohol and Alcoholism (Oxford, Oxfordshire). PMID 35544033 DOI: 10.1093/alcalc/agac015  0.485
2022 Kirkland AE, Browning BD, Green R, Leggio L, Meyerhoff DJ, Squeglia LM. Brain metabolite alterations related to alcohol use: a meta-analysis of proton magnetic resonance spectroscopy studies. Molecular Psychiatry. PMID 35508628 DOI: 10.1038/s41380-022-01594-8  0.449
2022 Wang T, Farokhnia M, Leggio L. FGF21 regulates alcohol intake: New hopes on the rise for alcohol use disorder treatment? Cell Reports. Medicine. 3: 100578. PMID 35492877 DOI: 10.1016/j.xcrm.2022.100578  0.512
2022 Leggio L, Mellinger JL. Alcohol use disorder in community management of chronic liver diseases. Hepatology (Baltimore, Md.). PMID 35434815 DOI: 10.1002/hep.32531  0.484
2022 Varodayan FP, Patel RR, Matzeu A, Wolfe SA, Curley DE, Khom S, Gandhi PJ, Rodriguez L, Bajo M, D'Ambrosio S, Sun H, Kerr TM, Gonzales RA, Leggio L, Natividad LA, et al. The Amygdala Noradrenergic System Is Compromised With Alcohol Use Disorder. Biological Psychiatry. PMID 35430085 DOI: 10.1016/j.biopsych.2022.02.006  0.442
2022 Mirijello A, Sestito L, Lauria C, Tarli C, Vassallo GA, Antonelli M, d'Angelo C, Ferrulli A, Crea F, Cossari A, Leggio L, De Cosmo S, Gasbarrini A, Addolorato G. Echocardiographic markers of early alcoholic cardiomyopathy: Six-month longitudinal study in heavy drinking patients. European Journal of Internal Medicine. PMID 35418346 DOI: 10.1016/j.ejim.2022.04.005  0.528
2022 DiMartini AF, Leggio L, Singal AK. Barriers to the management of alcohol use disorder and alcohol-associated liver disease: strategies to implement integrated care models. The Lancet. Gastroenterology & Hepatology. 7: 186-195. PMID 35026172 DOI: 10.1016/S2468-1253(21)00191-6  0.503
2021 Piacentino D, Grant-Beurmann S, Vizioli C, Li X, Moore CF, Ruiz-Rodado V, Lee MR, Joseph PV, Fraser CM, Weerts EM, Leggio L. Gut microbiome and metabolome in a non-human primate model of chronic excessive alcohol drinking. Translational Psychiatry. 11: 609. PMID 34853299 DOI: 10.1038/s41398-021-01728-6  0.531
2021 Traccis F, Presciuttini R, Pani PP, Sinclair JMA, Leggio L, Agabio R. Alcohol-medication interactions: A systematic review and meta-analysis of placebo-controlled trials. Neuroscience and Biobehavioral Reviews. 132: 519-541. PMID 34826511 DOI: 10.1016/j.neubiorev.2021.11.019  0.439
2021 Haass-Koffler CL, Perciballi R, Magill M, Loche A, Cacciaglia R, Leggio L, Swift RM. An inpatient human laboratory study assessing the safety and tolerability, pharmacokinetics, and biobehavioral effect of GET 73 when co-administered with alcohol in individuals with alcohol use disorder. Psychopharmacology. PMID 34731268 DOI: 10.1007/s00213-021-06008-1  0.505
2021 Agabio R, Leggio L. Thiamine administration to patients with alcohol use disorder: why not? The American Journal of Drug and Alcohol Abuse. 47: 651-654. PMID 34710331 DOI: 10.1080/00952990.2021.1978474  0.478
2021 Sulima A, Akhlaghi F, Leggio L, Rice KC. Synthesis of PF-6870961, a major hydroxy metabolite of the novel ghrelin receptor inverse agonist PF-5190457. Bioorganic & Medicinal Chemistry. 50: 116465. PMID 34662828 DOI: 10.1016/j.bmc.2021.116465  0.367
2021 Kärkkäinen O, Farokhnia M, Klåvus A, Auriola S, Lehtonen M, Deschaine SL, Piacentino D, Abshire KM, Jackson SN, Leggio L. Effect of intravenous ghrelin administration, combined with alcohol, on circulating metabolome in heavy drinking individuals with alcohol use disorder. Alcoholism, Clinical and Experimental Research. PMID 34590334 DOI: 10.1111/acer.14719  0.578
2021 Goodyear K, Vasaturo-Kolodner TR, Kenna GA, Swift RM, Leggio L, Haass-Koffler CL. Alcohol-related changes in behaviors and characteristics from the baseline to the randomization session for treatment and non-treatment seeking participants with alcohol use disorder. The American Journal of Drug and Alcohol Abuse. 47: 760-768. PMID 34582281 DOI: 10.1080/00952990.2021.1961799  0.399
2021 Browning BD, Schwandt ML, Farokhnia M, Deschaine SL, Hodgkinson CA, Leggio L. Leptin Gene and Leptin Receptor Gene Polymorphisms in Alcohol Use Disorder: Findings Related to Psychopathology. Frontiers in Psychiatry. 12: 723059. PMID 34421692 DOI: 10.3389/fpsyt.2021.723059  0.416
2021 Scherrer B, Guiraud J, Addolorato G, Aubin HJ, de Bejczy A, Benyamina A, van den Brink W, Caputo F, Dematteis M, Goudriaan AE, Gual A, Kiefer F, Leggio L, Lesch OM, Maremmani I, et al. Baseline severity and the prediction of placebo response in clinical trials for alcohol dependence: A meta-regression analysis to develop an enrichment strategy. Alcoholism, Clinical and Experimental Research. PMID 34418121 DOI: 10.1111/acer.14670  0.362
2021 Leggio L, Litten RZ. The GABA-B receptor agonist baclofen helps patients with alcohol use disorder: why these findings matter. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 34400781 DOI: 10.1038/s41386-021-01142-y  0.334
2021 Palzes VA, Farokhnia M, Kline-Simon AH, Elson J, Sterling S, Leggio L, Weisner C, Chi FW. Effectiveness of spironolactone dispensation in reducing weekly alcohol use: a retrospective high-dimensional propensity score-matched cohort study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 34341493 DOI: 10.1038/s41386-021-01117-z  0.476
2021 Farokhnia M, Murphy G, Weinstein SJ, Shah NN, Parisi D, Albanes D, Leggio L. A population-based investigation of the association between alcohol intake and serum total ghrelin concentrations among cigarette-smoking, non-alcohol-dependent male individuals. Drug and Alcohol Dependence. 226: 108835. PMID 34214881 DOI: 10.1016/j.drugalcdep.2021.108835  0.514
2021 Harris JC, Mereish EH, Faulkner ML, Assari S, Choi K, Leggio L, Farokhnia M. Racial Differences in the Association Between Alcohol Drinking and Cigarette Smoking: Preliminary Findings From an Alcohol Research Program. Alcohol and Alcoholism (Oxford, Oxfordshire). PMID 34086845 DOI: 10.1093/alcalc/agab038  0.613
2021 Lee MR, Abshire KM, Farokhnia M, Akhlaghi F, Leggio L. Effect of oral alcohol administration on plasma cytokine concentrations in heavy drinking individuals. Drug and Alcohol Dependence. 225: 108771. PMID 34052691 DOI: 10.1016/j.drugalcdep.2021.108771  0.479
2021 Deschaine SL, Farokhnia M, Gregory-Flores A, Zallar LJ, You ZB, Sun H, Harvey DM, Marchette RCN, Tunstall BJ, Mani BK, Moose JE, Lee MR, Gardner E, Akhlaghi F, Roberto M, ... ... Leggio L, et al. A closer look at alcohol-induced changes in the ghrelin system: novel insights from preclinical and clinical data. Addiction Biology. e13033. PMID 33908131 DOI: 10.1111/adb.13033  0.538
2021 Faulkner ML, Momenan R, Leggio L. A neuroimaging investigation into the role of peripheral metabolic biomarkers in the anticipation of reward in alcohol use. Drug and Alcohol Dependence. 221: 108638. PMID 33667782 DOI: 10.1016/j.drugalcdep.2021.108638  0.664
2021 Farinelli LA, Piacentino D, Browning BD, Brewer BB, Leggio L. Cardiovascular Consequences of Excessive Alcohol Drinking via Electrocardiogram: A Systematic Review. Journal of Addictions Nursing. 32: 39-45. PMID 33646717 DOI: 10.1097/JAN.0000000000000384  0.514
2021 Agarwal K, Manza P, Leggio L, Livinski AA, Volkow ND, Joseph PV. Sensory Cue Reactivity: Sensitization in Alcohol Use Disorder and Obesity. Neuroscience and Biobehavioral Reviews. PMID 33587959 DOI: 10.1016/j.neubiorev.2021.02.014  0.647
2021 Farokhnia M, Abshire KM, Hammer A, Deschaine SL, Saravanakumar A, Cobbina E, You ZB, Haass-Koffler CL, Lee MR, Akhlaghi F, Leggio L. Neuroendocrine response to exogenous ghrelin administration, combined with alcohol, in heavy-drinking individuals: Findings from a randomized, double-blind, placebo-controlled human laboratory study. The International Journal of Neuropsychopharmacology. PMID 33560411 DOI: 10.1093/ijnp/pyab004  0.57
2021 Agabio R, Baldwin DS, Amaro H, Leggio L, Sinclair JMA. The influence of anxiety symptoms on clinical outcomes during baclofen treatment of alcohol use disorder: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews. PMID 33454289 DOI: 10.1016/j.neubiorev.2020.12.030  0.364
2020 Marty VN, Farokhnia M, Munier JJ, Mulpuri Y, Leggio L, Spigelman I. Long-Acting Glucagon-Like Peptide-1 Receptor Agonists Suppress Voluntary Alcohol Intake in Male Wistar Rats. Frontiers in Neuroscience. 14: 599646. PMID 33424537 DOI: 10.3389/fnins.2020.599646  0.387
2020 Cobbina E, Lee MR, Leggio L, Akhlaghi F. A Population Pharmacokinetic Analysis of PF-5190457, a Novel Ghrelin Receptor Inverse Agonist in Healthy Volunteers and in Heavy Alcohol Drinkers. Clinical Pharmacokinetics. PMID 33155163 DOI: 10.1007/s40262-020-00942-7  0.532
2020 Haass-Koffler CL, Piacentino D, Li X, Long VM, Lee MR, Swift RM, Kenna GA, Leggio L. Differences in Sociodemographic and Alcohol-Related Clinical Characteristics Between Treatment Seekers and Nontreatment Seekers and Their Role in Predicting Outcomes in the COMBINE Study of Alcohol Use Disorder. Alcoholism, Clinical and Experimental Research. PMID 32997422 DOI: 10.1111/acer.14428  0.489
2020 Portelli J, Farokhnia M, Deschaine SL, Battista JT, Lee MR, Li X, Ron D, Leggio L. Investigating the link between serum concentrations of brain-derived neurotrophic factor and behavioral measures in anxious alcohol-dependent individuals. Alcohol (Fayetteville, N.Y.). PMID 32798692 DOI: 10.1016/j.alcohol.2020.07.009  0.454
2020 Spagnolo PA, Montemitro C, Leggio L. New Challenges in Addiction Medicine: COVID-19 Infection in Patients With Alcohol and Substance Use Disorders-The Perfect Storm. The American Journal of Psychiatry. appiajp202020040417. PMID 32660296 DOI: 10.1176/Appi.Ajp.2020.20040417  0.425
2020 Gray JC, Murphy M, Leggio L. Leveraging genetic data to investigate molecular targets and drug repurposing candidates for treating alcohol use disorder and hepatotoxicity. Drug and Alcohol Dependence. 214: 108155. PMID 32652377 DOI: 10.1016/j.drugalcdep.2020.108155  0.422
2020 Haass-Koffler CL, Perciballi R, Brown ZE, Lee MR, Zywiak WH, Kurtis J, Swift RM, Leggio L. Brief Report: Relationship Between Cotinine Levels and Peripheral Endogenous Concentrations of Oxytocin, β-Endorphin, and Orexin in Individuals With Both Alcohol and Nicotine Use Disorders. The American Journal On Addictions. PMID 32488890 DOI: 10.1111/Ajad.13064  0.416
2020 Farokhnia M, Portelli J, Lee MR, McDiarmid GR, Munjal V, Abshire KM, Battista JT, Browning BD, Deschaine SL, Akhlaghi F, Leggio L. Effects of exogenous ghrelin administration and ghrelin receptor blockade, in combination with alcohol, on peripheral inflammatory markers in heavy-drinking individuals: Results from two human laboratory studies. Brain Research. 146851. PMID 32339499 DOI: 10.1016/J.Brainres.2020.146851  0.414
2020 Ehinger Y, Phamluong K, Darevesky D, Welman M, Moffat JJ, Sakhai SA, Whiteley EL, Berger AL, Laguesse S, Farokhnia M, Leggio L, Lordkipanidzé M, Ron D. Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use. Addiction Biology. e12890. PMID 32135570 DOI: 10.1111/adb.12890  0.465
2020 Daurio AM, Deschaine SL, Modabbernia A, Leggio L. Parsing out the role of dopamine D4 receptor gene (DRD4) on alcohol-related phenotypes: A meta-analysis and systematic review. Addiction Biology. 25: e12770. PMID 31149768 DOI: 10.1111/adb.12770  0.446
2019 Litten RZ, Falk DE, Ryan ML, Fertig J, Leggio L. Five Priority Areas for Improving Medications Development for Alcohol Use Disorder and Promoting Their Routine Use in Clinical Practice. Alcoholism, Clinical and Experimental Research. PMID 31803968 DOI: 10.1111/acer.14233  0.36
2019 Witkiewitz K, Litten RZ, Leggio L. Advances in the science and treatment of alcohol use disorder. Science Advances. 5: eaax4043. PMID 31579824 DOI: 10.1126/Sciadv.Aax4043  0.508
2019 Lee MR, Farokhnia M, Cobbina E, Saravanakumar A, Li X, Battista JT, Farinelli LA, Akhlaghi F, Leggio L. Endocrine effects of the novel ghrelin receptor inverse agonist PF-5190457: Results from a placebo-controlled human laboratory alcohol co-administration study in heavy drinkers. Neuropharmacology. 107788. PMID 31557492 DOI: 10.1016/J.Neuropharm.2019.107788  0.46
2019 Portelli J, Wiers CE, Li X, Deschaine SL, McDiarmid GR, Bermpohl F, Leggio L. Peripheral proinflammatory markers are upregulated in abstinent alcohol-dependent patients but are not affected by cognitive bias modification: Preliminary findings. Drug and Alcohol Dependence. 204: 107553. PMID 31541874 DOI: 10.1016/j.drugalcdep.2019.107553  0.336
2019 Lee MR, Sankar V, Hammer A, Kennedy WG, Barb JJ, McQueen PG, Leggio L. Using Machine Learning to Classify Individuals With Alcohol Use Disorder Based on Treatment Seeking Status. Eclinicalmedicine. 12: 70-78. PMID 31388665 DOI: 10.1016/J.Eclinm.2019.05.008  0.407
2019 Lee MR, Shin JH, Deschaine S, Daurio AM, Stangl BL, Yan J, Ramchandani VA, Schwandt ML, Grodin EN, Momenan R, Corral-Frias NS, Hariri AR, Bogdan R, Alvarez VA, Leggio L. A role for the rs3796863 polymorphism in alcohol and monetary reward: evidence from CD38 knockout mice and alcohol self-administration, [11C]-raclopride binding, and functional MRI in humans. The American Journal of Drug and Alcohol Abuse. 1-13. PMID 31365285 DOI: 10.1080/00952990.2019.1638928  0.358
2019 Haass-Koffler CL, Long VM, Farokhnia M, Magill M, Kenna GA, Swift RM, Leggio L. Intravenous administration of ghrelin increases serum cortisol and aldosterone concentrations in heavy-drinking alcohol-dependent individuals: Results from a double-blind, placebo-controlled human laboratory study. Neuropharmacology. 107711. PMID 31310775 DOI: 10.1016/j.neuropharm.2019.107711  0.502
2019 Agabio R, Leggio L. HIV and alcohol use disorder: we cannot ignore the elephant in the room. The Lancet. Hiv. 6: e485-e486. PMID 31109914 DOI: 10.1016/S2352-3018(19)30074-8  0.388
2019 Farokhnia M, Browning BD, Leggio L. Prospects for pharmacotherapies to treat alcohol use disorder: an update on recent human studies. Current Opinion in Psychiatry. PMID 31107292 DOI: 10.1097/YCO.0000000000000519  0.504
2019 Tunstall BJ, Kirson D, Zallar LJ, McConnell SA, Vendruscolo JCM, Ho CP, Oleata CS, Khom S, Manning M, Lee MR, Leggio L, Koob GF, Roberto M, Vendruscolo LF. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala. Plos Biology. 17: e2006421. PMID 30990816 DOI: 10.1371/Journal.Pbio.2006421  0.537
2019 Farokhnia M, Faulkner ML, Piacentino D, Lee MR, Leggio L. Ghrelin: From a gut hormone to a potential therapeutic target for alcohol use disorder. Physiology & Behavior. PMID 30738971 DOI: 10.1016/j.physbeh.2019.02.008  0.691
2019 Byrd N, Stangl B, Schwandt M, Farokhnia M, Leggio L, Ramchandani V. 3465 EXAMINING THE EFFECTS OF CHILDHOOD TRAUMA ON ADULT ALCOHOL CONSUMPTION: DOES RACE AND/OR SEX MATTER? Journal of Clinical and Translational Science. 3: 44-44. DOI: 10.1017/cts.2019.104  0.416
2019 Agabio R, Sinclair J, Leggio L. The Cagliari Statement on baclofen for the treatment of alcohol use disorder: An International Consensus French Journal of Psychiatry. 1: S28. DOI: 10.1016/j.fjpsy.2019.10.216  0.481
2018 Zallar LJ, Beurmann S, Tunstall BJ, Fraser CM, Koob GF, Vendruscolo LF, Leggio L. Ghrelin receptor deletion reduces binge-like alcohol drinking in rats. Journal of Neuroendocrinology. e12663. PMID 30456835 DOI: 10.1111/Jne.12663  0.534
2018 Agabio R, Sinclair JM, Addolorato G, Aubin HJ, Beraha EM, Caputo F, Chick JD, de La Selle P, Franchitto N, Garbutt JC, Haber PS, Heydtman M, Jaury P, Lingford-Hughes AR, Morley KC, ... ... Leggio L, et al. Baclofen for the treatment of alcohol use disorder: the Cagliari Statement. The Lancet. Psychiatry. PMID 30413394 DOI: 10.1016/S2215-0366(18)30303-1  0.484
2018 Agabio R, Sinclair JM, Leggio L. Baclofen and alcohol in France - Authors' reply. The Lancet. Psychiatry. 5: 962-963. PMID 30413393 DOI: 10.1016/S2215-0366(18)30433-4  0.528
2018 Falk DE, Ryan ML, Fertig JB, Devine EG, Cruz R, Brown ES, Burns H, Salloum IM, Newport DJ, Mendelson J, Galloway G, Kampman K, Brooks C, Green AI, Brunette MF, ... ... Leggio L, et al. Gabapentin Enacarbil Extended-Release for Alcohol Use Disorder: A Randomized, Double-Blind, Placebo-Controlled, Multisite Trial assessing Efficacy and Safety. Alcoholism, Clinical and Experimental Research. PMID 30403402 DOI: 10.1111/Acer.13917  0.421
2018 Farokhnia M, Deschaine SL, Sadighi A, Farinelli LA, Lee MR, Akhlaghi F, Leggio L. A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation. Molecular Psychiatry. PMID 30382188 DOI: 10.1038/S41380-018-0287-Y  0.539
2018 Leggio L, de Witte P, Chick J. Alcohol and Alcoholism: Then, Now and The Future of 'The Red Journal'. Alcohol and Alcoholism (Oxford, Oxfordshire). 53: 637-638. PMID 30339185 DOI: 10.1093/alcalc/agy075  0.55
2018 Agabio R, Leggio L. Baclofen in the Treatment of Patients With Alcohol Use Disorder and Other Mental Health Disorders. Frontiers in Psychiatry. 9: 464. PMID 30323774 DOI: 10.3389/fpsyt.2018.00464  0.325
2018 Farokhnia M, Lee MR, Farinelli LA, Ramchandani VA, Akhlaghi F, Leggio L. Pharmacological manipulation of the ghrelin system and alcohol hangover symptoms in heavy drinking individuals: Is there a link? Pharmacology, Biochemistry, and Behavior. PMID 30030128 DOI: 10.1016/J.Pbb.2018.07.004  0.532
2018 Morley KC, Baillie A, van den Brink W, Chitty K, Brady K, Back S, Sutherland G, Seth D, Leggio L, Haber PS. Rationale for N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease. Expert Opinion On Investigational Drugs. PMID 30019966 DOI: 10.1080/13543784.2018.1501471  0.501
2018 Bouhlal S, Farokhnia M, Lee MR, Akhlaghi F, Leggio L. Identifying and Characterizing Subpopulations of Heavy Alcohol Drinkers Via a Sucrose Preference Test: A Sweet Road to a Better Phenotypic Characterization? Alcohol and Alcoholism (Oxford, Oxfordshire). PMID 30016385 DOI: 10.1093/Alcalc/Agy048  0.448
2018 Morris LS, Voon V, Leggio L. Stress, motivation and the gut-brain axis: A focus on the ghrelin system and alcohol use disorder. Alcoholism, Clinical and Experimental Research. PMID 29797564 DOI: 10.1111/acer.13781  0.399
2018 Lee MR, Tapocik JD, Ghareeb M, Schwandt ML, Dias AA, Le AN, Cobbina E, Farinelli LA, Bouhlal S, Farokhnia M, Heilig M, Akhlaghi F, Leggio L. The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study. Molecular Psychiatry. PMID 29728704 DOI: 10.1038/S41380-018-0064-Y  0.519
2018 Haass-Koffler CL, Goodyear K, Zywiak WH, Leggio L, Kenna GA, Swift RM. Corrigendum: Comparing and Combining Topiramate and Aripiprazole on Alcohol-Related Outcomes in a Human Laboratory Study. Alcohol and Alcoholism (Oxford, Oxfordshire). PMID 29718153 DOI: 10.1093/alcalc/agy030  0.461
2018 Farokhnia M, Sheskier MB, Lee MR, Le AN, Singley E, Bouhlal S, Ton T, Zhao Z, Leggio L. Neuroendocrine response to GABA-B receptor agonism in alcohol-dependent individuals: Results from a combined outpatient and human laboratory experiment. Neuropharmacology. PMID 29665351 DOI: 10.1016/j.neuropharm.2018.04.011  0.424
2018 Haass-Koffler CL, Swift RM, Leggio L. Noradrenergic targets for the treatment of alcohol use disorder. Psychopharmacology. PMID 29460163 DOI: 10.1007/s00213-018-4843-6  0.419
2018 Haass-Koffler CL, Goodyear K, Loche A, Long VM, Lobina C, Tran HH, Cacciaglia R, Swift RM, Colombo G, Leggio L. Administration of the metabotropic glutamate receptor subtype 5 allosteric modulator GET7 3 with alcohol: A translational study in rats and humans. Journal of Psychopharmacology (Oxford, England). 269881117746904. PMID 29361897 DOI: 10.1177/0269881117746904  0.488
2018 Litten RZ, Falk DE, Ryan ML, Fertig J, Leggio L. Advances in Pharmacotherapy Development: Human Clinical Studies. Handbook of Experimental Pharmacology. PMID 29294197 DOI: 10.1007/164_2017_79  0.306
2017 Haass-Koffler CL, Goodyear K, Zywiak WH, Leggio L, Kenna GA, Swift RM. Comparing and Combining Topiramate and Aripiprazole on Alcohol-Related Outcomes in a Human Laboratory Study. Alcohol and Alcoholism (Oxford, Oxfordshire). PMID 29281033 DOI: 10.1093/alcalc/agx108  0.397
2017 Farokhnia M, Grodin EN, Lee MR, Oot EN, Blackburn AN, Stangl BL, Schwandt ML, Farinelli LA, Momenan R, Ramchandani VA, Leggio L. Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals. Molecular Psychiatry. PMID 29133954 DOI: 10.1038/Mp.2017.226  0.565
2017 Daurio AM, Aston SA, Schwandt ML, Bukhari MO, Bouhlal S, Farokhnia M, Lee MR, Leggio L. Impulsive personality traits mediate the relationship between adult attention deficit hyperactivity symptoms and alcohol dependence severity. Alcoholism, Clinical and Experimental Research. PMID 29063627 DOI: 10.1111/Acer.13538  0.309
2017 Lee MR, Schwandt ML, Sankar V, Suchankova P, Sun H, Leggio L. Effect of alcohol use disorder on oxytocin peptide and receptor mRNA expression in human brain: A post-mortem case-control study. Psychoneuroendocrinology. 85: 14-19. PMID 28787642 DOI: 10.1016/J.Psyneuen.2017.07.481  0.498
2017 Haass-Koffler CL, Goodyear K, Zywiak WH, Magill M, Eltinge SE, Wallace PM, Long VM, Jayaram-Lindström N, Swift RM, Kenna GA, Leggio L. Higher pretreatment blood pressure is associated with greater alcohol drinking reduction in alcohol-dependent individuals treated with doxazosin. Drug and Alcohol Dependence. 177: 23-28. PMID 28551590 DOI: 10.1016/j.drugalcdep.2017.03.016  0.484
2017 Temko JE, Bouhlal S, Farokhnia M, Lee MR, Cryan JF, Leggio L. The Microbiota, the Gut and the Brain in Eating and Alcohol Use Disorders: A 'Ménage à Trois'? Alcohol and Alcoholism (Oxford, Oxfordshire). 1-11. PMID 28482009 DOI: 10.1093/alcalc/agx024  0.38
2017 Suchankova P, Yan J, Schwandt ML, Stangl BL, Jerlhag E, Engel JA, Hodgkinson CA, Ramchandani VA, Leggio L. The Leu72Met Polymorphism of the Prepro-ghrelin Gene is Associated With Alcohol Consumption and Subjective Responses to Alcohol: Preliminary Findings. Alcohol and Alcoholism (Oxford, Oxfordshire). 1-6. PMID 28481975 DOI: 10.1093/Alcalc/Agx021  0.541
2017 Aoun EG, Jimenez VA, Vendruscolo LF, Walter NAR, Barbier E, Ferrulli A, Haass-Koffler CL, Darakjian P, Lee MR, Addolorato G, Heilig M, Hitzemann R, Koob GF, Grant KA, Leggio L. A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans. Molecular Psychiatry. PMID 28461696 DOI: 10.1038/Mp.2017.97  0.394
2017 Farokhnia M, Schwandt ML, Lee MR, Bollinger JW, Farinelli LA, Amodio JP, Sewell L, Lionetti TA, Spero DE, Leggio L. Biobehavioral effects of baclofen in anxious alcohol-dependent individuals: a randomized, double-blind, placebo-controlled, laboratory study. Translational Psychiatry. 7: e1108. PMID 28440812 DOI: 10.1038/Tp.2017.71  0.561
2017 Rohn MC, Lee MR, Kleuter SB, Schwandt ML, Falk DE, Leggio L. Differences Between Treatment-Seeking and Nontreatment-Seeking Alcohol-Dependent Research Participants: An Exploratory Analysis. Alcoholism, Clinical and Experimental Research. 41: 414-420. PMID 28129451 DOI: 10.1111/Acer.13304  0.477
2017 Haass-Koffler CL, Akhlaghi F, Swift RM, Leggio L. Altering ethanol pharmacokinetics to treat alcohol use disorder: Can you teach an old dog new tricks? Journal of Psychopharmacology (Oxford, England). 269881116684338. PMID 28093021 DOI: 10.1177/0269881116684338  0.456
2017 Haass-Koffler CL, Henry AT, Melkus G, Simms JA, Naemmuddin M, Nielsen CK, Lasek AW, Magill M, Schwandt ML, Momenan R, Hodgkinson CA, Bartlett SE, Swift RM, Bonci A, Leggio L. A chimeric approach to evaluate the role of corticotropin releasing factor in alcohol use disorder Alcohol. 60: 222-223. DOI: 10.1016/J.Alcohol.2017.02.267  0.405
2017 Leggio L. Ghrelin as potential new pathway toward medication development for alcohol use disorder: Recent clinical data Alcohol. 60: 218. DOI: 10.1016/J.ALCOHOL.2017.02.248  0.397
2016 Leggio L, Lee MR. Treatment of Alcohol Use Disorder in Patients with Alcoholic Liver Disease. The American Journal of Medicine. PMID 27984008 DOI: 10.1016/j.amjmed.2016.10.004  0.508
2016 Goodyear K, Lee MR, Schwandt ML, Hodgkinson CA, Leggio L. Hepatic, lipid and genetic factors associated with obesity: crosstalk with alcohol dependence? The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 1-9. PMID 27905213 DOI: 10.1080/15622975.2016.1249952  0.447
2016 Haass-Koffler CL, Henry AT, Melkus G, Simms JA, Naemmuddin M, Nielsen CK, Lasek AW, Magill M, Schwandt ML, Momenan R, Hodgkinson CA, Bartlett SE, Swift RM, Bonci A, Leggio L. Defining the role of corticotropin releasing factor binding protein in alcohol consumption. Translational Psychiatry. 6: e953. PMID 27845775 DOI: 10.1038/Tp.2016.208  0.374
2016 Martinotti G, Lupi M, Carlucci L, Santacroce R, Cinosi E, Acciavatti T, Sarchione F, Verrastro V, Diotaiuti P, Petruccelli I, Ferrari S, Nanni MG, Pinna F, Volpe U, Saggino A, ... ... Leggio L, et al. Alcohol drinking patterns in young people: A survey-based study. Journal of Health Psychology. PMID 27624615 DOI: 10.1177/1359105316667795  0.438
2016 Blackburn AN, Hajnal A, Leggio L. The gut in the brain: the effects of bariatric surgery on alcohol consumption. Addiction Biology. PMID 27578259 DOI: 10.1111/adb.12436  0.472
2016 Haass-Koffler CL, Giovenco DE, Lee MR, Zywiak WH, de la Monte SM, Kenna GA, Swift RM, Leggio L. Serum Insulin Levels are Reduced by Intravenous Ghrelin Administration but do not Correlate with Alcohol Craving in Alcohol Dependent Individuals. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). PMID 27207912 DOI: 10.1093/ijnp/pyw048  0.446
2016 Schwandt ML, Cortes CR, Kwako LE, George DT, Momenan R, Sinha R, Grigoriadis DE, Leggio L, Heilig M. The CRF1 Antagonist Verucerfont in Anxious Alcohol Dependent Women: Translation of Neuroendocrine, but not of Anti-Craving Effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27109623 DOI: 10.1038/Npp.2016.61  0.511
2016 Lee MR, Rohn MC, Tanda G, Leggio L. Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date. Cns Drugs. PMID 26932552 DOI: 10.1007/s40263-016-0313-z  0.364
2016 Heilig M, Leggio L. What the alcohol doctor ordered from the neuroscientist: Theragnostic biomarkers for personalized treatments. Progress in Brain Research. 224: 401-18. PMID 26822368 DOI: 10.1016/Bs.Pbr.2015.07.023  0.482
2016 Leggio L. Role of the ghrelin system in alcoholism: Acting on the growth hormone secretagogue receptor to treat alcohol-related diseases. Drug News & Perspectives. 23: 157-66. PMID 20440417 DOI: 10.1358/dnp.2010.23.3.1429490  0.543
2016 Joseph PV, Fourie NH, Ferguson E, Abey SK, Walter P, Sherwin LB, Rahim-Williams B, Leggio L, Henderson WA. Sa1982 Liquid Chromatography Mass Spectrometry Based Analysis of Human Response to Synthetic Sugar Challenge and the Microbiome Gastroenterology. 150. DOI: 10.1016/S0016-5085(16)31470-6  0.614
2015 Lee MR, Leggio L. Management of Alcohol Use Disorder in Patients Requiring Liver Transplant. The American Journal of Psychiatry. 172: 1182-9. PMID 26619772 DOI: 10.1176/appi.ajp.2015.15040567  0.347
2015 Haass-Koffler CL, Aoun EG, Swift RM, de la Monte SM, Kenna GA, Leggio L. Leptin levels are reduced by intravenous ghrelin administration and correlated with cue-induced alcohol craving. Translational Psychiatry. 5: e646. PMID 26418274 DOI: 10.1038/tp.2015.140  0.505
2015 Lee MR, Schwandt ML, Bollinger JW, Dias AA, Oot EN, Goldman D, Hodgkinson CA, Leggio L. Effect of Functionally Significant Deiodinase Single Nucleotide Polymorphisms on Drinking Behavior in Alcohol Dependence: An Exploratory Investigation. Alcoholism, Clinical and Experimental Research. PMID 26207529 DOI: 10.1111/Acer.12814  0.448
2015 Suchankova P, Yan J, Schwandt ML, Stangl BL, Caparelli EC, Momenan R, Jerlhag E, Engel JA, Hodgkinson CA, Egli M, Lopez MF, Becker HC, Goldman D, Heilig M, Ramchandani VA, ... Leggio L, et al. The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence. Translational Psychiatry. 5: e583. PMID 26080318 DOI: 10.1038/Tp.2015.68  0.542
2015 Kenna GA, Haass-Koffler CL, Zywiak WH, Edwards SM, Brickley MB, Swift RM, Leggio L. Role of the α1 blocker doxazosin in alcoholism: a proof-of-concept randomized controlled trial. Addiction Biology. PMID 26037245 DOI: 10.1111/adb.12275  0.415
2015 Farokhnia M, Edwards SM, Bollinger J, Amodio J, Zywiak WH, Tidey JW, Swift RM, Kenna GA, Leggio L. T76. Baclofen as a pharmacotherapy for the treatment of concurrent alcohol and nicotine dependence: a double-blind, placebo-controlled, randomized trial. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1560. PMID 25868070 DOI: 10.1038/Npp.2015.29  0.327
2015 Haass-Koffler CL, Leggio L, Davidson D, Swift RM. Effects of idazoxan on alcohol pharmacokinetics and intoxication: a preliminary human laboratory study. Alcoholism, Clinical and Experimental Research. 39: 594-602. PMID 25833022 DOI: 10.1111/Acer.12658  0.543
2015 Leggio L, Zywiak WH, Edwards SM, Tidey JW, Swift RM, Kenna GA. Erratum to: a preliminary double-blind, placebo-controlled randomized study of baclofen effects in alcoholic smokers. Psychopharmacology. 232: 1667. PMID 25804430 DOI: 10.1007/s00213-015-3916-z  0.445
2015 Mirijello A, D'Angelo C, Ferrulli A, Vassallo G, Antonelli M, Caputo F, Leggio L, Gasbarrini A, Addolorato G. Identification and management of alcohol withdrawal syndrome. Drugs. 75: 353-65. PMID 25666543 DOI: 10.1007/s40265-015-0358-1  0.368
2015 Aoun EG, Lee MR, Haass-Koffler CL, Swift RM, Addolorato G, Kenna GA, Leggio L. Relationship between the thyroid axis and alcohol craving. Alcohol and Alcoholism (Oxford, Oxfordshire). 50: 24-9. PMID 25433251 DOI: 10.1093/alcalc/agu085  0.379
2015 Hillemacher T, Leggio L, Heberlein A. Investigational therapies for the pharmacological treatment of alcoholism. Expert Opinion On Investigational Drugs. 24: 17-30. PMID 25164385 DOI: 10.1517/13543784.2014.954037  0.46
2015 Leggio L, Zywiak WH, Edwards SM, Tidey JW, Swift RM, Kenna GA. A preliminary double-blind, placebo-controlled randomized study of baclofen effects in alcoholic smokers. Psychopharmacology. 232: 233-43. PMID 24973894 DOI: 10.1007/S00213-014-3652-9  0.49
2015 Kenna G, Haass-Koffler C, Swift R, Zywiak W, Brickley M, Edwards S, Leggio L. P86A PILOT DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL USING DOXAZOSIN FOR ALCOHOL DEPENDENCE Alcohol and Alcoholism. 50: i67.2-i67. DOI: 10.1093/alcalc/agv080.86  0.424
2015 Suchankova P, Yan, J, Schwandt ML, Stangl BL, Caparelli EC, Momenan R, Hodgkinson CA, Goldman D, Heilig M, Ramchandani VA, Nilsson S, von der Pahlen B, Santtila P, Sandnabba K, ... ... Leggio L, et al. SY15-3THE ROLE OF THE GUT-BRAIN-AXIS IN SUBSTANCE USE DISORDERS: EVIDENCE FROM HUMAN GENETIC STUDIES Alcohol and Alcoholism. 50: i18.1-i18. DOI: 10.1093/Alcalc/Agv076.63  0.324
2015 Leggio L. SY09-5UPDATE ON EFFECTIVE TREATMENTS FOR ALCOHOL USE DISORDER: RIDING THE WAVES OF MEDICATIONS DEVELOPMENT Alcohol and Alcoholism. 50: i11.3-i11. DOI: 10.1093/ALCALC/AGV076.38  0.372
2014 Morley KC, Baillie A, Leung S, Addolorato G, Leggio L, Haber PS. Baclofen for the Treatment of Alcohol Dependence and Possible Role of Comorbid Anxiety. Alcohol and Alcoholism (Oxford, Oxfordshire). PMID 25246489 DOI: 10.1093/Alcalc/Agu062  0.449
2014 Kenna GA, Zywiak WH, Swift RM, McGeary JE, Clifford JS, Shoaff JR, Fricchione S, Brickley M, Beaucage K, Haass-Koffler CL, Leggio L. Ondansetron and sertraline may interact with 5-HTTLPR and DRD4 polymorphisms to reduce drinking in non-treatment seeking alcohol-dependent women: exploratory findings. Alcohol (Fayetteville, N.Y.). 48: 515-22. PMID 25212749 DOI: 10.1016/J.Alcohol.2014.04.005  0.35
2014 Vuittonet CL, Halse M, Leggio L, Fricchione SB, Brickley M, Haass-Koffler CL, Tavares T, Swift RM, Kenna GA. Pharmacotherapy for alcoholic patients with alcoholic liver disease. American Journal of Health-System Pharmacy : Ajhp : Official Journal of the American Society of Health-System Pharmacists. 71: 1265-76. PMID 25027533 DOI: 10.2146/ajhp140028  0.447
2014 Leggio L, Schwandt ML. Topiramate for alcoholism treatment: novel pharmacogenetic evidence for the journey to personalized medicine? The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 17: 1541-4. PMID 24892413 DOI: 10.1017/S1461145714000790  0.336
2014 Leggio L, Zywiak WH, Fricchione SR, Edwards SM, de la Monte SM, Swift RM, Kenna GA. Intravenous ghrelin administration increases alcohol craving in alcohol-dependent heavy drinkers: a preliminary investigation. Biological Psychiatry. 76: 734-41. PMID 24775991 DOI: 10.1016/j.biopsych.2014.03.019  0.567
2014 Kenna GA, Zywiak WH, Swift RM, McGeary JE, Clifford JS, Shoaff JR, Vuittonet C, Fricchione S, Brickley M, Beaucage K, Haass-Koffler CL, Leggio L. Ondansetron reduces naturalistic drinking in nontreatment-seeking alcohol-dependent individuals with the LL 5'-HTTLPR genotype: a laboratory study. Alcoholism, Clinical and Experimental Research. 38: 1567-74. PMID 24773166 DOI: 10.1111/Acer.12410  0.421
2014 Haass-Koffler CL, Leggio L, Kenna GA. Pharmacological approaches to reducing craving in patients with alcohol use disorders. Cns Drugs. 28: 343-60. PMID 24573997 DOI: 10.1007/s40263-014-0149-3  0.503
2014 Lee MR, Leggio L. Combined pharmacotherapies for the management of alcoholism: rationale and evidence to date. Cns Drugs. 28: 107-19. PMID 24497006 DOI: 10.1007/s40263-013-0137-z  0.388
2013 Polston JE, Pritchett CE, Tomasko JM, Rogers AM, Leggio L, Thanos PK, Volkow ND, Hajnal A. Roux-en-Y gastric bypass increases intravenous ethanol self-administration in dietary obese rats. Plos One. 8: e83741. PMID 24391816 DOI: 10.1371/Journal.Pone.0083741  0.443
2013 Leggio L, Schwandt ML, Oot EN, Dias AA, Ramchandani VA. Fasting-induced increase in plasma ghrelin is blunted by intravenous alcohol administration: a within-subject placebo-controlled study. Psychoneuroendocrinology. 38: 3085-91. PMID 24090583 DOI: 10.1016/J.Psyneuen.2013.09.005  0.546
2013 Addolorato G, Mirijello A, Leggio L. Alcohol addiction: toward a patient-oriented pharmacological treatment. Expert Opinion On Pharmacotherapy. 14: 2157-60. PMID 23984836 DOI: 10.1517/14656566.2013.834047  0.463
2013 Gurvich EM, Kenna GA, Leggio L. Use of novel technology-based techniques to improve alcohol-related outcomes in clinical trials. Alcohol and Alcoholism (Oxford, Oxfordshire). 48: 712-9. PMID 23955872 DOI: 10.1093/alcalc/agt134  0.441
2013 Addolorato G, Mirijello A, Leggio L, Ferrulli A, D'Angelo C, Vassallo G, Cossari A, Gasbarrini G, Landolfi R, Agnes S, Gasbarrini A, Abbate V, Abenavoli L, Antonelli M, Annicchiarico E, et al. Liver transplantation in alcoholic patients: Impact of an alcohol addiction unit within a liver transplant center Alcoholism: Clinical and Experimental Research. 37: 1601-1608. PMID 23578009 DOI: 10.1111/acer.12117  0.436
2013 Addolorato G, Mirijello A, Leggio L, Ferrulli A, Landolfi R. Management of alcohol dependence in patients with liver disease. Cns Drugs. 27: 287-99. PMID 23456576 DOI: 10.1007/s40263-013-0043-4  0.507
2013 Leggio L, Kenna GA. Commentary: Doxazosin for alcoholism. Alcoholism, Clinical and Experimental Research. 37: 191-3. PMID 23278505 DOI: 10.1111/acer.12064  0.406
2013 Leggio L, Zywiak WH, McGeary JE, Edwards S, Fricchione SR, Shoaff JR, Addolorato G, Swift RM, Kenna GA. A human laboratory pilot study with baclofen in alcoholic individuals. Pharmacology, Biochemistry, and Behavior. 103: 784-91. PMID 23262301 DOI: 10.1016/J.Pbb.2012.11.013  0.56
2013 Johnson B, Seneviratne C, Franklin J, Beckett K, Ma J, Ait-Daoud N, Payne T, Johnson B, Li M, Ait-Daoud N, Kenna G, Zywiak WH, McGeary JE, Swift RM, Clifford JS, ... ... Leggio L, et al. S02 * SEROTONIN SYSTEM IN ALCOHOLISM: INDIVIDUAL DIFFERENCES AND TREATMENT Alcohol and Alcoholism. 48: i3-i4. DOI: 10.1093/Alcalc/Agt074  0.47
2012 Heberlein A, Leggio L, Stichtenoth D, Hillemacher T. The treatment of alcohol and opioid dependence in pregnant women. Current Opinion in Psychiatry. 25: 559-64. PMID 23037965 DOI: 10.1097/YCO.0b013e328358ad36  0.331
2012 Kenna GA, Swift RM, Hillemacher T, Leggio L. The relationship of appetitive, reproductive and posterior pituitary hormones to alcoholism and craving in humans. Neuropsychology Review. 22: 211-28. PMID 22772772 DOI: 10.1007/s11065-012-9209-y  0.553
2012 Tang YL, Hao W, Leggio L. Treatments for alcohol-related disorders in China: a developing story. Alcohol and Alcoholism (Oxford, Oxfordshire). 47: 563-70. PMID 22683652 DOI: 10.1093/alcalc/ags066  0.341
2012 Caputo F, Vignoli T, Leggio L, Addolorato G, Zoli G, Bernardi M. Alcohol use disorders in the elderly: a brief overview from epidemiology to treatment options. Experimental Gerontology. 47: 411-6. PMID 22575256 DOI: 10.1016/j.exger.2012.03.019  0.53
2012 Leggio L, Promrat K, Kenna GA. A Call to Action: Alcohol Interventions in HIV-Infected Patients. Frontiers in Psychiatry. 3: 35. PMID 22529825 DOI: 10.3389/fpsyt.2012.00035  0.315
2012 Leggio L, Ferrulli A, Zambon A, Caputo F, Kenna GA, Swift RM, Addolorato G. Baclofen promotes alcohol abstinence in alcohol dependent cirrhotic patients with hepatitis C virus (HCV) infection. Addictive Behaviors. 37: 561-4. PMID 22244707 DOI: 10.1016/j.addbeh.2011.12.010  0.398
2012 Addolorato G, Leggio L, Hopf FW, Diana M, Bonci A. Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 163-77. PMID 22030714 DOI: 10.1038/npp.2011.216  0.358
2012 Leggio L, Ferrulli A, Cardone S, Nesci A, Miceli A, Malandrino N, Capristo E, Canestrelli B, Monteleone P, Kenna GA, Swift RM, Addolorato G. Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving. Addiction Biology. 17: 452-64. PMID 21392177 DOI: 10.1111/j.1369-1600.2010.00308.x  0.535
2011 Leggio L, Kenna GA, Ferrulli A, Zywiak WH, Caputo F, Swift RM, Addolorato G. Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease. Human Psychopharmacology. 26: 554-9. PMID 22095793 DOI: 10.1002/hup.1244  0.538
2011 Addolorato G, Leggio L, Ferrulli A, Cardone S, Bedogni G, Caputo F, Gasbarrini G, Landolfi R. Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial. Alcohol and Alcoholism (Oxford, Oxfordshire). 46: 312-7. PMID 21414953 DOI: 10.1093/alcalc/agr017  0.396
2011 Caputo F, Francini S, Brambilla R, Vigna-Taglianti F, Stoppo M, Del Re A, Leggio L, Addolorato G, Zoli G, Bernardi M. Sodium oxybate in maintaining alcohol abstinence in alcoholic patients with and without psychiatric comorbidity. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 21: 450-6. PMID 21276717 DOI: 10.1016/j.euroneuro.2010.12.005  0.54
2011 Leggio L, Addolorato G, Cippitelli A, Jerlhag E, Kampov-Polevoy AB, Swift RM. Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelin. Alcoholism, Clinical and Experimental Research. 35: 194-202. PMID 21058960 DOI: 10.1111/j.1530-0277.2010.01334.x  0.511
2011 Montalto M, Gallo A, Ferrulli A, Visca D, Campobasso E, Cardone S, D'Onofrio F, Santoro L, Covino M, Mirijello A, Leggio L, Gasbarrini G, Addolorato G. Fecal calprotectin concentrations in alcoholic patients: a longitudinal study. European Journal of Gastroenterology & Hepatology. 23: 76-80. PMID 21030869 DOI: 10.1097/MEG.0b013e32834101f9  0.525
2011 Leggio L. Alcohol and Tobacco. Medical and Sociological Aspects of Use, Abuse and Addiction Alcohol and Alcoholism. 46: 366-366. DOI: 10.1093/ALCALC/AGR022  0.432
2011 Leggio L. S.08.04 Relationship between ghrelin and alcohol craving and intake: recent clinical findings European Neuropsychopharmacology. 21: S199. DOI: 10.1016/S0924-977X(11)70272-3  0.471
2010 Ray LA, Krull JL, Leggio L. The Effects of Naltrexone Among Alcohol Non-Abstainers: Results from the COMBINE Study. Frontiers in Psychiatry. 1: 26. PMID 21423437 DOI: 10.3389/Fpsyt.2010.00026  0.492
2010 Ferrulli A, Leggio L, Cardone S, D'Angelo C, Mirijello A, Vonghia L, Miceli A, Gasbarrini G, Addolorato G. Psychosocial findings in alcohol-dependent patients before and after three months of total alcohol abstinence. Frontiers in Psychiatry. 1: 17. PMID 21423428 DOI: 10.3389/fpsyt.2010.00017  0.475
2010 Addolorato G, Leggio L. Pregabalin similar to lorazepam for alcohol withdrawal symptoms. Evidence-Based Medicine. 15: 73. PMID 20522678 DOI: 10.1136/ebm1069  0.437
2010 Addolorato G, Leggio L. Safety and efficacy of baclofen in the treatment of alcohol-dependent patients. Current Pharmaceutical Design. 16: 2113-7. PMID 20482507  0.525
2010 Leggio L, Cardone S, Ferrulli A, Kenna GA, Diana M, Swift RM, Addolorato G. Turning the clock ahead: potential preclinical and clinical neuropharmacological targets for alcohol dependence. Current Pharmaceutical Design. 16: 2159-18. PMID 20482506 DOI: 10.2174/138161210791516369  0.448
2010 Leggio L, Addolorato G. Pharmacotherapy of alcohol dependence: past, present and future research. Current Pharmaceutical Design. 16: 2074-5. PMID 20482504  0.548
2010 Leggio L, Garbutt JC, Addolorato G. Effectiveness and safety of baclofen in the treatment of alcohol dependent patients. Cns & Neurological Disorders Drug Targets. 9: 33-44. PMID 20201813 DOI: 10.2174/187152710790966614  0.532
2009 Addolorato G, Leggio L, Cardone S, Ferrulli A, Gasbarrini G. Role of the GABA(B) receptor system in alcoholism and stress: focus on clinical studies and treatment perspectives. Alcohol (Fayetteville, N.Y.). 43: 559-63. PMID 19913201 DOI: 10.1016/j.alcohol.2009.09.031  0.511
2009 Kenna GA, Lomastro TL, Schiesl A, Leggio L, Swift RM. Review of topiramate: an antiepileptic for the treatment of alcohol dependence. Current Drug Abuse Reviews. 2: 135-42. PMID 19630744 DOI: 10.2174/1874473710902020135  0.491
2009 Kenna GA, Leggio L, Swift RM. A safety and tolerability laboratory study of the combination of aripiprazole and topiramate in volunteers who drink alcohol. Human Psychopharmacology. 24: 465-72. PMID 19551762 DOI: 10.1002/hup.1042  0.525
2009 Leggio L, Ray LA, Kenna GA, Swift RM. Blood glucose level, alcohol heavy drinking, and alcohol craving during treatment for alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) Study. Alcoholism, Clinical and Experimental Research. 33: 1539-44. PMID 19485973 DOI: 10.1111/J.1530-0277.2009.00982.X  0.394
2009 Leggio L. Understanding and treating alcohol craving and dependence: recent pharmacological and neuroendocrinological findings. Alcohol and Alcoholism (Oxford, Oxfordshire). 44: 341-52. PMID 19451661 DOI: 10.1093/alcalc/agp026  0.525
2009 Addolorato G, Russell M, Albano E, Haber PS, Wands JR, Leggio L. Understanding and treating patients with alcoholic cirrhosis: an update. Alcoholism, Clinical and Experimental Research. 33: 1136-44. PMID 19389182 DOI: 10.1111/J.1530-0277.2009.00956.X  0.541
2009 Addolorato G, Leggio L, Ferrulli A, Caputo F, Gasbarrini A. The therapeutic potential of gamma-hydroxybutyric acid for alcohol dependence: balancing the risks and benefits. A focus on clinical data. Expert Opinion On Investigational Drugs. 18: 675-86. PMID 19379123 DOI: 10.1517/13543780902905855   0.517
2009 Addolorato G, Leggio L, Hillemacher T, Kraus T, Jerlhag E, Bleich S. Hormones and drinking behaviour: new findings on ghrelin, insulin, leptin and volume-regulating hormones. An ESBRA Symposium report. Drug and Alcohol Review. 28: 160-5. PMID 19320701 DOI: 10.1111/J.1465-3362.2008.00023.X  0.437
2009 Leggio L, Kenna GA, Fenton M, Bonenfant E, Swift RM. Typologies of alcohol dependence. From Jellinek to genetics and beyond. Neuropsychology Review. 19: 115-29. PMID 19184441 DOI: 10.1007/S11065-008-9080-Z  0.408
2009 Leggio L, Malandrino N, Ferrulli A, Cardone S, Miceli A, Gasbarrini G, Capristo E, Addolorato G. Is cortisol involved in the alcohol-related fat mass impairment? A longitudinal clinical study. Alcohol and Alcoholism (Oxford, Oxfordshire). 44: 211-5. PMID 19144979 DOI: 10.1093/alcalc/agn116  0.481
2009 Kenna GA, Zywiak WH, McGeary JE, Leggio L, McGeary C, Wang S, Grenga A, Swift RM. A within-group design of nontreatment seeking 5-HTTLPR genotyped alcohol-dependent subjects receiving ondansetron and sertraline. Alcoholism, Clinical and Experimental Research. 33: 315-23. PMID 19032576 DOI: 10.1111/J.1530-0277.2008.00835.X  0.438
2009 Ray LA, Mackillop J, Leggio L, Morgan M, Hutchison KE. Effects of naltrexone on cortisol levels in heavy drinkers. Pharmacology, Biochemistry, and Behavior. 91: 489-94. PMID 18824022 DOI: 10.1016/J.Pbb.2008.09.004  0.502
2009 Swift R, Leggio L. Adjunctive pharmacotherapy in the treatment of alcohol and drug dependence Evidence-Based Addiction Treatment. 287-310. DOI: 10.1016/B978-0-12-374348-0.00015-X  0.433
2008 Vonghia L, Leggio L, Ferrulli A, Bertini M, Gasbarrini G, Addolorato G. Acute alcohol intoxication. European Journal of Internal Medicine. 19: 561-7. PMID 19046719 DOI: 10.1016/j.ejim.2007.06.033  0.514
2008 Leggio L, Ferrulli A, Cardone S, Malandrino N, Mirijello A, D'Angelo C, Vonghia L, Miceli A, Capristo E, Kenna GA, Gasbarrini G, Swift RM, Addolorato G. Relationship between the hypothalamic-pituitary-thyroid axis and alcohol craving in alcohol-dependent patients: a longitudinal study. Alcoholism, Clinical and Experimental Research. 32: 2047-53. PMID 18828809 DOI: 10.1111/j.1530-0277.2008.00792.x  0.399
2008 Caputo F, Francini S, Stoppo M, Lorenzini F, Vignoli T, Del Re A, Comaschi C, Leggio L, Addolorato G, Zoli G, Bernardi M. Incidence of craving for and abuse of gamma-hydroxybutyric acid (GHB) in different populations of treated alcoholics: an open comparative study. Journal of Psychopharmacology (Oxford, England). 23: 883-90. PMID 18635689 DOI: 10.1177/0269881108094620  0.456
2008 Leggio L, Ferrulli A, Cardone S, Miceli A, Kenna GA, Gasbarrini G, Swift RM, Addolorato G. Renin and aldosterone but not the natriuretic peptide correlate with obsessive craving in medium-term abstinent alcohol-dependent patients: a longitudinal study. Alcohol (Fayetteville, N.Y.). 42: 375-81. PMID 18486430 DOI: 10.1016/j.alcohol.2008.03.128  0.45
2008 Leggio L, Addolorato G. Serotonin transporter (SERT) brain density and neurobiological Cloninger subtypes model: a lesson by human autoradiography studies. Alcohol and Alcoholism (Oxford, Oxfordshire). 43: 148-50. PMID 18211952 DOI: 10.1093/alcalc/agm169  0.554
2008 Leggio L, Kenna GA, Swift RM. New developments for the pharmacological treatment of alcohol withdrawal syndrome. A focus on non-benzodiazepine GABAergic medications. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 32: 1106-17. PMID 18029075 DOI: 10.1016/j.pnpbp.2007.09.021  0.477
2007 Abenavoli L, Bardazzi G, Cracolici F, Quaranta C, Santini G, Graziosi S, Polero L, Leggio L, Addolorato G. Complementary therapies for treating alcoholism First Annual meeting by Complementary Medicine Research Group of the Italian Society for Alcohol Studies-May 5, 2006, Florence, Italy. Fitoterapia. 79: 142-7. PMID 18187264 DOI: 10.1016/j.fitote.2007.11.016  0.5
2007 Addolorato G, Leggio L, Ferrulli A, Cardone S, Vonghia L, Mirijello A, Abenavoli L, D'Angelo C, Caputo F, Zambon A, Haber PS, Gasbarrini G. Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study. Lancet (London, England). 370: 1915-22. PMID 18068515 DOI: 10.1016/S0140-6736(07)61814-5  0.454
2007 Addolorato G, Leggio L, Agabio R, Colombo G, Gasbarrini G. Baclofen: a new drug for the treatment of alcohol dependence. International Journal of Clinical Practice. 60: 1003-8. PMID 16893442 DOI: 10.1111/j.1742-1241.2006.01065.x  0.514
2006 Addolorato G, Capristo E, Leggio L, Ferrulli A, Abenavoli L, Malandrino N, Farnetti S, Domenicali M, D'Angelo C, Vonghia L, Mirijello A, Cardone S, Gasbarrini G. Relationship between ghrelin levels, alcohol craving, and nutritional status in current alcoholic patients. Alcoholism, Clinical and Experimental Research. 30: 1933-7. PMID 17067359 DOI: 10.1111/J.1530-0277.2006.00238.X  0.485
2006 Bardazzi G, Merluzzi JA, Voller F, Fontana A, Abenavoli L, Leggio L, Addolorato G. Complementary medicine for alcohol dependence in Italian services: a mail questionnaire. Complementary Therapies in Clinical Practice. 12: 216-21. PMID 16835034 DOI: 10.1016/J.CTCP.2005.12.003  0.436
2006 Ferrulli A, Leggio L, Abenavoli L, Farnetti S, Malandrino N, D'Angelo C, Vonghia L, Mirijello A, Cardone S, Leso V, Domenicali M, Caputo F, Bernardi M, Stefanini G, Capristo E, et al. Ghrelin in alcohol-dependent patients and correlation with nutritional status and craving Digestive and Liver Disease. 38: S160. DOI: 10.1016/S1590-8658(06)80433-0  0.469
2006 Leggio L, Abenavoli L, Ferrulli A, Agabio R, D'Angelo C, Vonghia L, Mirijello A, Malandrino N, Cardone S, Capristo E, Caputo F, Bernardi M, Stefanini G, Colombo G, Gessa G, et al. Baclofen in the treatment of alcohol withdrawal syndrome: A randomized comparative study versus diazepam Digestive and Liver Disease. 38: S96. DOI: 10.1016/S1590-8658(06)80257-4  0.454
2005 Addolorato G, Leggio L, Abenavoli L, Gasbarrini G. Neurobiochemical and clinical aspects of craving in alcohol addiction: a review. Addictive Behaviors. 30: 1209-24. PMID 15925129 DOI: 10.1016/J.ADDBEH.2004.12.011  0.422
2005 Leggio L, Abenavoli L, Caputo F, Gasbarrini G, Addolorato G. Baclofen use in the treatment of alcohol delirium tremens. Archives of Internal Medicine. 165: 586; author reply 58. PMID 15767538 DOI: 10.1001/ARCHINTE.165.5.586-A  0.508
2005 Addolorato G, Abenavoli L, Leggio L, Gasbarrini G. How many cravings? Pharmacological aspects of craving treatment in alcohol addiction: a review. Neuropsychobiology. 51: 59-66. PMID 15741745 DOI: 10.1159/000084161  0.454
2005 Addolorato G, Leggio L, Abenavoli L, Caputo F, Gasbarrini G. Baclofen for outpatient treatment of alcohol withdrawal syndrome. The Journal of Family Practice. 54: 24. PMID 15623403  0.457
2004 Addolorato G, Leggio L, Abenavoli L, Caputo F, Gasbarrini G. Tolerance to baclofen's sedative effect in alcohol-addicted patients: no dissipation after a period of abstinence. Psychopharmacology. 178: 351-2. PMID 15719231 DOI: 10.1007/s00213-004-2014-4  0.496
2003 Addolorato G, Leggio L, Abenavoli L, DeLorenzi G, Parente A, Caputo F, Janiri L, Capristo E, Rapaccini GL, Gasbarrini G. Suppression of alcohol delirium tremens by baclofen administration: a case report. Clinical Neuropharmacology. 26: 258-62. PMID 14520166 DOI: 10.1097/00002826-200309000-00010  0.417
Show low-probability matches.