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213 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Menting JG, Yang Y, Chan SJ, Phillips NB, Smith BJ, Whittaker J, Wickramasinghe NP, Whittaker LJ, Pandyarajan V, Wan ZL, Yadav SP, Carroll JM, Strokes N, Roberts CT, Ismail-Beigi F, ... ... Steiner DF, et al. Protective hinge in insulin opens to enable its receptor engagement. Proceedings of the National Academy of Sciences of the United States of America. 111: E3395-404. PMID 25092300 DOI: 10.1073/pnas.1412897111  1
2014 Park SY, Ludwig MZ, Tamarina NA, He BZ, Carl SH, Dickerson DA, Barse L, Arun B, Williams CL, Miles CM, Philipson LH, Steiner DF, Bell GI, Kreitman M. Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin. Genetics. 196: 539-55. PMID 24281154 DOI: 10.1534/genetics.113.157602  1
2013 Kanatsuna N, Taneera J, Vaziri-Sani F, Wierup N, Larsson HE, Delli A, Skärstrand H, Balhuizen A, Bennet H, Steiner DF, Törn C, Fex M, Lernmark Ã…. Autoimmunity against INS-IGF2 protein expressed in human pancreatic islets. The Journal of Biological Chemistry. 288: 29013-23. PMID 23935095 DOI: 10.1074/jbc.M113.478222  1
2013 Menting JG, Whittaker J, Margetts MB, Whittaker LJ, Kong GK, Smith BJ, Watson CJ, Záková L, Kletvíková E, Jiráček J, Chan SJ, Steiner DF, Dodson GG, Brzozowski AM, Weiss MA, et al. How insulin engages its primary binding site on the insulin receptor. Nature. 493: 241-5. PMID 23302862 DOI: 10.1038/nature11781  1
2012 Cyr NE, Stuart RC, Zhu X, Steiner DF, Nillni EA. Biosynthesis of proTRH-derived peptides in prohormone convertase 1 and 2 knockout mice. Peptides. 35: 42-8. PMID 22421509 DOI: 10.1016/j.peptides.2012.02.024  1
2012 Refaie S, Gagnon S, Gagnon H, Desjardins R, D'Anjou F, D'Orléans-Juste P, Zhu X, Steiner DF, Seidah NG, Lazure C, Salzet M, Day R. Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion. The Journal of Biological Chemistry. 287: 14703-17. PMID 22396549 DOI: 10.1074/jbc.M111.323220  1
2011 Steiner DF. On the discovery of precursor processing. Methods in Molecular Biology (Clifton, N.J.). 768: 3-11. PMID 21805235 DOI: 10.1007/978-1-61779-204-5_1  1
2011 Steiner DF. Adventures with insulin in the islets of Langerhans. The Journal of Biological Chemistry. 286: 17399-421. PMID 21454641 DOI: 10.1074/jbc.X111.244764  1
2011 Stein J, Milewski WM, Hara M, Steiner DF, Dey A. GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1). Islets. 3: 21-34. PMID 21278490 DOI: 10.4161/isl.3.1.14435  1
2010 Vlacich G, Nawijn MC, Webb GC, Steiner DF. Pim3 negatively regulates glucose-stimulated insulin secretion. Islets. 2: 308-17. PMID 21099329 DOI: 10.4161/isl.2.5.13058  1
2010 Støy J, Steiner DF, Park SY, Ye H, Philipson LH, Bell GI. Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene. Reviews in Endocrine & Metabolic Disorders. 11: 205-15. PMID 20938745 DOI: 10.1007/s11154-010-9151-3  1
2010 Kilimnik G, Kim A, Steiner DF, Friedman TC, Hara M. Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of ß-cell regeneration. Islets. 2: 149-55. PMID 20657753  1
2010 Wardman JH, Zhang X, Gagnon S, Castro LM, Zhu X, Steiner DF, Day R, Fricker LD. Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics. Journal of Neurochemistry. 114: 215-25. PMID 20412386 DOI: 10.1111/j.1471-4159.2010.06760.x  1
2010 Smith BJ, Huang K, Kong G, Chan SJ, Nakagawa S, Menting JG, Hu SQ, Whittaker J, Steiner DF, Katsoyannis PG, Ward CW, Weiss MA, Lawrence MC. Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists. Proceedings of the National Academy of Sciences of the United States of America. 107: 6771-6. PMID 20348418 DOI: 10.1073/pnas.1001813107  1
2010 Park SY, Ye H, Steiner DF, Bell GI. Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted. Biochemical and Biophysical Research Communications. 391: 1449-54. PMID 20034470 DOI: 10.1016/j.bbrc.2009.12.090  1
2010 Zhang X, Pan H, Peng B, Steiner DF, Pintar JE, Fricker LD. Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis. Journal of Neurochemistry. 112: 1168-79. PMID 19968759 DOI: 10.1111/j.1471-4159.2009.06530.x  1
2010 Kilimnik G, Kim A, Steiner DF, Friedman TC, Hara M. Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic alpha-cells in mouse models of beta-cell regeneration Islets. 2.  1
2009 Steiner DF, Park SY, Støy J, Philipson LH, Bell GI. A brief perspective on insulin production. Diabetes, Obesity & Metabolism. 11: 189-96. PMID 19817801 DOI: 10.1111/j.1463-1326.2009.01106.x  1
2009 Ahrén B, Accili D, Boitard C, Efendic S, Henquin JC, Seino S, Steiner DF, Cerasi E. β-Cell research - A decade of rapid growth. Diabetes, Obesity & Metabolism. 11: iv-ix. PMID 19817782 DOI: 10.1111/j.1463-1326.2009.01143.x  1
2009 Solberg Woods LC, Ahmadiyeh N, Baum A, Shimomura K, Li Q, Steiner DF, Turek FW, Takahashi JS, Churchill GA, Redei EE. Identification of genetic loci involved in diabetes using a rat model of depression. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 20: 486-97. PMID 19697080 DOI: 10.1007/s00335-009-9211-8  1
2009 Kharouta M, Miller K, Kim A, Wojcik P, Kilimnik G, Dey A, Steiner DF, Hara M. No mantle formation in rodent islets -- the prototype of islet revisited. Diabetes Research and Clinical Practice. 85: 252-7. PMID 19595468 DOI: 10.1016/j.diabres.2009.06.021  1
2009 Zhan S, Zhao H, J White A, Minami M, Pignataro G, Yang T, Zhu X, Lan J, Xiong Z, Steiner DF, Simon RP, Zhou A. Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 698-706. PMID 19142196 DOI: 10.1038/jcbfm.2008.161  1
2008 Henquin JC, Cerasi E, Efendic S, Steiner DF, Boitard C. Pancreatic beta-cell mass or beta-cell function? That is the question! Diabetes, Obesity & Metabolism. 10: 1-4. PMID 18834427 DOI: 10.1111/j.1463-1326.2008.00968.x  1
2008 Rehfeld JF, Zhu X, Norrbom C, Bundgaard JR, Johnsen AH, Nielsen JE, Vikesaa J, Stein J, Dey A, Steiner DF, Friis-Hansen L. Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17. The Biochemical Journal. 415: 35-43. PMID 18554181 DOI: 10.1042/BJ20080881  1
2008 Molven A, Ringdal M, Nordbø AM, Raeder H, Støy J, Lipkind GM, Steiner DF, Philipson LH, Bergmann I, Aarskog D, Undlien DE, Joner G, Søvik O, Bell GI, et al. Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes. Diabetes. 57: 1131-5. PMID 18192540 DOI: 10.2337/db07-1467  1
2008 Edghill EL, Flanagan SE, Patch AM, Boustred C, Parrish A, Shields B, Shepherd MH, Hussain K, Kapoor RR, Malecki M, MacDonald MJ, Støy J, Steiner DF, Philipson LH, Bell GI, et al. Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood. Diabetes. 57: 1034-42. PMID 18162506 DOI: 10.2337/db07-1405  1
2008 Rehfeld JF, Bundgaard JR, Hannibal J, Zhu X, Norrbom C, Steiner DF, Friis-Hansen L. The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6. Endocrinology. 149: 1600-8. PMID 18096669 DOI: 10.1210/en.2007-0278  1
2008 Steiner DF. The biosynthesis of insulin Pancreatic Beta Cell in Health and Disease. 31-49. DOI: 10.1007/978-4-431-75452-7_3  1
2007 Efendic S, Boitard C, Ferrannini E, Henquin JC, Steiner DF, Cerasi E. Of mighty mice and diabetic men: animal models of islet dysfunction. Diabetes, Obesity & Metabolism. 9: 1-4. PMID 17919172 DOI: 10.1111/j.1463-1326.2007.00809.x  1
2007 Huang K, Chan SJ, Hua QX, Chu YC, Wang RY, Klaproth B, Jia W, Whittaker J, De Meyts P, Nakagawa SH, Steiner DF, Katsoyannis PG, Weiss MA. The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice. The Journal of Biological Chemistry. 282: 35337-49. PMID 17884811 DOI: 10.1074/jbc.M705996200  1
2007 Støy J, Edghill EL, Flanagan SE, Ye H, Paz VP, Pluzhnikov A, Below JE, Hayes MG, Cox NJ, Lipkind GM, Lipton RB, Greeley SA, Patch AM, Ellard S, Steiner DF, et al. Insulin gene mutations as a cause of permanent neonatal diabetes. Proceedings of the National Academy of Sciences of the United States of America. 104: 15040-4. PMID 17855560 DOI: 10.1073/pnas.0707291104  1
2007 Kedees MH, Guz Y, Vuguin PM, Vargas C, Cui L, Steiner DF, Charron MJ, Teitelman G. Nestin expression in pancreatic endocrine and exocrine cells of mice lacking glucagon signaling. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 236: 1126-33. PMID 17366624 DOI: 10.1002/dvdy.21112  1
2007 Chan SJ, Nakagawa S, Steiner DF. Complementation analysis demonstrates that insulin cross-links both alpha subunits in a truncated insulin receptor dimer. The Journal of Biological Chemistry. 282: 13754-8. PMID 17339314 DOI: 10.1074/jbc.M700724200  1
2006 Zhu X, Cao Y, Voogd K, Voodg K, Steiner DF. On the processing of proghrelin to ghrelin. The Journal of Biological Chemistry. 281: 38867-70. PMID 17050541 DOI: 10.1074/jbc.M607955200  1
2006 Pan H, Che FY, Peng B, Steiner DF, Pintar JE, Fricker LD. The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study. Journal of Neurochemistry. 98: 1763-77. PMID 16903874 DOI: 10.1111/j.1471-4159.2006.04067.x  1
2006 Marzban L, Rhodes CJ, Steiner DF, Haataja L, Halban PA, Verchere CB. Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death. Diabetes. 55: 2192-201. PMID 16873681 DOI: 10.2337/db05-1566  1
2006 Wang J, Cao Y, Chen Y, Chen Y, Gardner P, Steiner DF. Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival. Proceedings of the National Academy of Sciences of the United States of America. 103: 10636-41. PMID 16815968 DOI: 10.1073/pnas.0604194103  1
2006 Stein J, Shah R, Steiner DF, Dey A. RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor. The Biochemical Journal. 400: 209-15. PMID 16800814 DOI: 10.1042/BJ20060506  1
2006 Stein J, Steiner DF, Dey A. Processing of cocaine- and amphetamine-regulated transcript (CART) precursor proteins by prohormone convertases (PCs) and its implications. Peptides. 27: 1919-25. PMID 16784796 DOI: 10.1016/j.peptides.2005.10.028  1
2006 Schlueter PJ, Royer T, Farah MH, Laser B, Chan SJ, Steiner DF, Duan C. Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1230-2. PMID 16705083 DOI: 10.1096/fj.05-3882fje  1
2006 Ugleholdt R, Poulsen ML, Holst PJ, Irminger JC, Orskov C, Pedersen J, Rosenkilde MM, Zhu X, Steiner DF, Holst JJ. Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor. The Journal of Biological Chemistry. 281: 11050-7. PMID 16476726 DOI: 10.1074/jbc.M601203200  1
2006 Creemers JW, Pritchard LE, Gyte A, Le Rouzic P, Meulemans S, Wardlaw SL, Zhu X, Steiner DF, Davies N, Armstrong D, Lawrence CB, Luckman SM, Schmitz CA, Davies RA, Brennand JC, et al. Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132: interaction between AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3. Endocrinology. 147: 1621-31. PMID 16384863 DOI: 10.1210/en.2005-1373  1
2006 Steiner DF, Boitard C, Cerasi E, Efendic S, Henquin JC, Ferrannini E. Toward a systems biology of insulin secretion and type 2 diabetes Diabetes. 55: S1-S4. DOI: 10.2337/db06-S000  1
2005 Boitard C, Efendic S, Ferrannini E, Henquin JC, Steiner DF, Cerasi E. A tale of two cousins: type 1 and type 2 diabetes. Diabetes. 54: S1-3. PMID 16306326 DOI: 10.2337/diabetes.54.suppl_2.S1  1
2005 Hardiman A, Friedman TC, Grunwald WC, Furuta M, Zhu Z, Steiner DF, Cool DR. Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry. Journal of Molecular Endocrinology. 34: 739-51. PMID 15956344 DOI: 10.1677/jme.1.01812  1
2005 Peinado JR, Laurent V, Lee SN, Peng BW, Pintar JE, Steiner DF, Lindberg I. Strain-dependent influences on the hypothalamo-pituitary-adrenal axis profoundly affect the 7B2 and PC2 null phenotypes. Endocrinology. 146: 3438-44. PMID 15878971 DOI: 10.1210/en.2004-1289  1
2005 Pan H, Nanno D, Che FY, Zhu X, Salton SR, Steiner DF, Fricker LD, Devi LA. Neuropeptide processing profile in mice lacking prohormone convertase-1. Biochemistry. 44: 4939-48. PMID 15779921 DOI: 10.1021/bi047852m  1
2005 Dey A, Lipkind GM, Rouillé Y, Norrbom C, Stein J, Zhang C, Carroll R, Steiner DF. Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon. Endocrinology. 146: 713-27. PMID 15528303 DOI: 10.1210/en.2004-1118  1
2004 Henquin JC, Boitard C, Cerasi E, Ferrannini E, Steiner DF, Efendic S. Impact of treatment on islet function in type 2 diabetes. Diabetes. 53: S1-5. PMID 15561896 DOI: 10.2337/diabetes.53.suppl_3.S1  1
2004 Steiner DF. The proinsulin C-peptide--a multirole model. Experimental Diabesity Research. 5: 7-14. PMID 15198367 DOI: 10.1080/15438600490424389  1
2004 Ma L, Bindokas VP, Kuznetsov A, Rhodes C, Hays L, Edwardson JM, Ueda K, Steiner DF, Philipson LH. Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion. Proceedings of the National Academy of Sciences of the United States of America. 101: 9266-71. PMID 15197259 DOI: 10.1073/pnas.0403201101  1
2004 Webb GC, Dey A, Wang J, Stein J, Milewski M, Steiner DF. Altered proglucagon processing in an alpha-cell line derived from prohormone convertase 2 null mouse islets. The Journal of Biological Chemistry. 279: 31068-75. PMID 15143067 DOI: 10.1074/jbc.M404110200  1
2004 Cain BM, Connolly K, Blum AC, Vishnuvardhan D, Marchand JE, Zhu X, Steiner DF, Beinfeld MC. Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these structures in rat brain. Journal of Neurochemistry. 89: 307-13. PMID 15056274 DOI: 10.1046/j.1471-4159.2003.02295.x  1
2004 Marzban L, Trigo-Gonzalez G, Zhu X, Rhodes CJ, Halban PA, Steiner DF, Verchere CB. Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide. Diabetes. 53: 141-8. PMID 14693708 DOI: 10.2337/diabetes.53.1.141  1
2004 Dey A, Norrbom C, Zhu X, Stein J, Zhang C, Ueda K, Steiner DF. Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone. Endocrinology. 145: 1961-71. PMID 14684599 DOI: 10.1210/en.2003-1472  1
2004 Ugleholdt R, Zhu X, Deacon CF, Ørskov C, Steiner DF, Holst JJ. Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1. Endocrinology. 145: 1349-55. PMID 14630721 DOI: 10.1210/en.2003-0801  1
2003 Wang J, Webb G, Cao Y, Steiner DF. Contrasting patterns of expression of transcription factors in pancreatic alpha and beta cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 12660-5. PMID 14557546 DOI: 10.1073/pnas.1735286100  1
2003 Vincent M, Guz Y, Rozenberg M, Webb G, Furuta M, Steiner D, Teitelman G. Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased α-cell proliferation, and islet neogenesis Endocrinology. 144: 4061-4069. PMID 12933680 DOI: 10.1210/en.2003-0088  1
2003 Wang J, Cao Y, Steiner DF. Regulation of proglucagon transcription by activated transcription factor (ATF) 3 and a novel isoform, ATF3b, through the cAMP-response element/ATF site of the proglucagon gene promoter. The Journal of Biological Chemistry. 278: 32899-904. PMID 12815047 DOI: 10.1074/jbc.M305456200  1
2003 Ueda K, Lipkind GM, Zhou A, Zhu X, Kuznetsov A, Philipson L, Gardner P, Zhang C, Steiner DF. Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1). Proceedings of the National Academy of Sciences of the United States of America. 100: 5622-7. PMID 12721373 DOI: 10.1073/pnas.0631617100  1
2003 Stanciu IN, Pitale S, Prinz RA, Jakate S, Webb G, Steiner D, Braithwaite S, Gordon D, Emanuele MA. Insulinoma presenting with hyperandrogenism: a case report and a literature review. Journal of Internal Medicine. 253: 484-9. PMID 12653879 DOI: 10.1046/j.1365-2796.2003.01132.x  1
2003 Lilla V, Webb G, Rickenbach K, Maturana A, Steiner DF, Halban PA, Irminger JC. Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines. Endocrinology. 144: 1368-79. PMID 12639920 DOI: 10.1210/en.2002-220916  1
2003 Dey A, Xhu X, Carroll R, Turck CW, Stein J, Steiner DF. Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3. The Journal of Biological Chemistry. 278: 15007-14. PMID 12584191 DOI: 10.1074/jbc.M212128200  1
2002 Efendic S, Boitard C, Cerasi E, Ferrannini E, Henquin JC, Steiner DF. Regulation of insulin production: In search of therapeutic targets Diabetes. 51: S285-S287. PMID 12475764  1
2002 Westermark GT, Falkmer S, Steiner DF, Chan SJ, Engström U, Westermark P. Islet amyloid polypeptide is expressed in the pancreatic islet parenchyma of the teleostean fish, Myoxocephalus (cottus) scorpius. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 133: 119-25. PMID 12223219 DOI: 10.1016/S1096-4959(02)00113-6  1
2002 Zhu X, Zhou A, Dey A, Norrbom C, Carroll R, Zhang C, Laurent V, Lindberg I, Ugleholdt R, Holst JJ, Steiner DF. Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proceedings of the National Academy of Sciences of the United States of America. 99: 10293-8. PMID 12145326 DOI: 10.1073/pnas.162352599  1
2002 Zhu X, Orci L, Carroll R, Norrbom C, Ravazzola M, Steiner DF. Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3. Proceedings of the National Academy of Sciences of the United States of America. 99: 10299-304. PMID 12136131 DOI: 10.1073/pnas.162352799  1
2002 Laurent V, Kimble A, Peng B, Zhu P, Pintar JE, Steiner DF, Lindberg I. Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion. Proceedings of the National Academy of Sciences of the United States of America. 99: 3087-92. PMID 11854475 DOI: 10.1073/pnas.261715099  1
2002 Henquin JC, Boitard C, Efendic S, Ferrannini E, Steiner DF, Cerasi E. Insulin secretion: movement at all levels. Diabetes. 51: S1-2. PMID 11815449  1
2002 Webb GC, Akbar MS, Zhao C, Swift HH, Steiner DF. Glucagon replacement via micro-osmotic pump corrects hypoglycemia and alpha-cell hyperplasia in prohormone convertase 2 knockout mice. Diabetes. 51: 398-405. PMID 11812747  1
2002 Steiner DF. 7 The prohormone convertases and precursor processing in protein biosynthesis Enzymes. 22: 163-198. DOI: 10.1016/S1874-6047(02)80008-7  1
2001 Furuta M, Zhou A, Webb G, Carroll R, Ravazzola M, Orci L, Steiner DF. Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice. The Journal of Biological Chemistry. 276: 27197-202. PMID 11356850 DOI: 10.1074/jbc.M103362200  1
2001 Webb GC, Akbar MS, Zhao C, Steiner DF. Expression profiling of pancreatic beta-cells: glucose regulation of secretory and metabolic pathway genes. Diabetes. 50: S135-6. PMID 11272173  1
2001 Cerasi E, Boitard C, Efendic S, Ferrannini E, Henquin JC, Steiner DF. The islet in type 2 diabetes: back to center stage. Diabetes. 50: S1-3. PMID 11272163  1
2001 Wang J, Xu J, Finnerty J, Furuta M, Steiner DF, Verchere CB. The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site. Diabetes. 50: 534-9. PMID 11246872  1
2000 Westermark GT, Gebre-Medhin S, Steiner DF, Westermark P. Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP. Molecular Medicine (Cambridge, Mass.). 6: 998-1007. PMID 11474116  1
2000 Kim SH, Wang R, Gordon DJ, Bass J, Steiner DF, Thinakaran G, Lynn DG, Meredith SC, Sisodia SS. Familial British dementia: expression and metabolism of BRI. Annals of the New York Academy of Sciences. 920: 93-9. PMID 11193182  1
2000 Nakagawa SH, Tager HS, Steiner DF. Mutational analysis of invariant valine B12 in insulin: implications for receptor binding. Biochemistry. 39: 15826-35. PMID 11123908 DOI: 10.1021/bi001802+  1
2000 Westermark GT, Steiner DF, Gebre-Medhin S, Engström U, Westermark P. Pro islet amyloid polypeptide (ProIAPP) immunoreactivity in the islets of Langerhans. Upsala Journal of Medical Sciences. 105: 97-106. PMID 11095107  1
2000 Bass J, Turck C, Rouard M, Steiner DF. Furin-mediated processing in the early secretory pathway: sequential cleavage and degradation of misfolded insulin receptors. Proceedings of the National Academy of Sciences of the United States of America. 97: 11905-9. PMID 11050224 DOI: 10.1073/pnas.97.22.11905  1
2000 Berman Y, Mzhavia N, Polonskaia A, Furuta M, Steiner DF, Pintar JE, Devi LA. Defective prodynorphin processing in mice lacking prohormone convertase PC2. Journal of Neurochemistry. 75: 1763-70. PMID 10987860 DOI: 10.1046/j.1471-4159.2000.0751763.x  1
2000 Webb GC, Akbar MS, Zhao C, Steiner DF. Expression profiling of pancreatic beta cells: glucose regulation of secretory and metabolic pathway genes. Proceedings of the National Academy of Sciences of the United States of America. 97: 5773-8. PMID 10811900 DOI: 10.1073/pnas.100126597  1
2000 Steiner DF. New aspects of proinsulin physiology and pathophysiology. Journal of Pediatric Endocrinology & Metabolism : Jpem. 13: 229-39. PMID 10714747  1
2000 Oliva AA, Chan SJ, Steiner DF. Evolution of the prohormone convertases: identification of a homologue of PC6 in the protochordate amphioxus. Biochimica Et Biophysica Acta. 1477: 338-48. PMID 10708868 DOI: 10.1016/S0167-4838(99)00283-6  1
1999 Kim SH, Wang R, Gordon DJ, Bass J, Steiner DF, Lynn DG, Thinakaran G, Meredith SC, Sisodia SS. Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia. Nature Neuroscience. 2: 984-8. PMID 10526337 DOI: 10.1038/14783  1
1999 Zhou A, Webb G, Zhu X, Steiner DF. Proteolytic processing in the secretory pathway. The Journal of Biological Chemistry. 274: 20745-8. PMID 10409610 DOI: 10.1074/jbc.274.30.20745  1
1999 Furukawa H, Carroll RJ, Swift HH, Steiner DF. Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6. Diabetes. 48: 1395-401. PMID 10389844 DOI: 10.2337/diabetes.48.7.1395  1
1999 Rouard M, Bass J, Grigorescu F, Garrett TP, Ward CW, Lipkind G, Jaffiole C, Steiner DF, Bell GI. Congenital insulin resistance associated with a conformational alteration in a conserved beta-sheet in the insulin receptor L1 domain. The Journal of Biological Chemistry. 274: 18487-91. PMID 10373457 DOI: 10.1074/jbc.274.26.18487  1
1999 Westermark G, Westermark P, Eizirik DL, Hellerström C, Fox N, Steiner DF, Andersson A. Differences in amyloid deposition in islets of transgenic mice expressing human islet amyloid polypeptide versus human islets implanted into nude mice. Metabolism: Clinical and Experimental. 48: 448-54. PMID 10206436  1
1999 Westphal CH, Muller L, Zhou A, Zhu X, Bonner-Weir S, Schambelan M, Steiner DF, Lindberg I, Leder P. The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease. Cell. 96: 689-700. PMID 10089884  1
1999 Viale A, Ortola C, Hervieu G, Furuta M, Barbero P, Steiner DF, Seidah NG, Nahon JL. Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals. The Journal of Biological Chemistry. 274: 6536-45. PMID 10037747 DOI: 10.1074/jbc.274.10.6536  1
1999 Lipkind G, Steiner DF. Predicted structural alterations in proinsulin during its interactions with prohormone convertases. Biochemistry. 38: 890-6. PMID 9893983 DOI: 10.1021/bi981556q  1
1998 Johanning K, Juliano MA, Juliano L, Lazure C, Lamango NS, Steiner DF, Lindberg I. Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates. The Journal of Biological Chemistry. 273: 22672-80. PMID 9712897 DOI: 10.1074/jbc.273.35.22672  1
1998 Steiner DF. The proprotein convertases. Current Opinion in Chemical Biology. 2: 31-9. PMID 9667917  1
1998 Duguay SJ, Jin Y, Stein J, Duguay AN, Gardner P, Steiner DF. Post-translational processing of the insulin-like growth factor-2 precursor. Analysis of O-glycosylation and endoproteolysis. The Journal of Biological Chemistry. 273: 18443-51. PMID 9660813 DOI: 10.1074/jbc.273.29.18443  1
1998 Lipkind GM, Zhou A, Steiner DF. A model for the structure of the P domains in the subtilisin-like prohormone convertases. Proceedings of the National Academy of Sciences of the United States of America. 95: 7310-5. PMID 9636145 DOI: 10.1073/pnas.95.13.7310  1
1998 Bass J, Chiu G, Argon Y, Steiner DF. Folding of insulin receptor monomers is facilitated by the molecular chaperones calnexin and calreticulin and impaired by rapid dimerization. The Journal of Cell Biology. 141: 637-46. PMID 9566965 DOI: 10.1083/jcb.141.3.637  1
1998 Zhou A, Martin S, Lipkind G, LaMendola J, Steiner DF. Regulatory roles of the P domain of the subtilisin-like prohormone convertases. The Journal of Biological Chemistry. 273: 11107-14. PMID 9556596 DOI: 10.1074/jbc.273.18.11107  1
1998 Takumi I, Steiner DF, Sanno N, Teramoto A, Osamura RY. Localization of prohormone convertases 1/3 and 2 in the human pituitary gland and pituitary adenomas: analysis by immunohistochemistry, immunoelectron microscopy, and laser scanning microscopy. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 11: 232-8. PMID 9521468  1
1998 Milewski WM, Duguay SJ, Chan SJ, Steiner DF. Conservation of PDX-1 structure, function, and expression in zebrafish. Endocrinology. 139: 1440-9. PMID 9492081 DOI: 10.1210/endo.139.3.5768  1
1998 Furuta M, Carroll R, Martin S, Swift HH, Ravazzola M, Orci L, Steiner DF. Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2. The Journal of Biological Chemistry. 273: 3431-7. PMID 9452465 DOI: 10.1074/jbc.273.6.3431  1
1997 Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF. Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. Dna and Cell Biology. 16: 1249-56. PMID 9364936  1
1997 Chan SJ, Plisetskaya EM, Urbinati E, Jin Y, Steiner DF. Expression of multiple insulin and insulin-like growth factor receptor genes in salmon gill cartilage. Proceedings of the National Academy of Sciences of the United States of America. 94: 12446-51. PMID 9356469 DOI: 10.1073/pnas.94.23.12446  1
1997 Varlamov O, Fricker LD, Furukawa H, Steiner DF, Langley SH, Leiter EH. β-cell lines derived from transgenic Cpe(fat)/Cpe(fat) mice are defective in carboxypeptidase E and proinsulin processing Endocrinology. 138: 4883-4892. PMID 9348219 DOI: 10.1210/en.138.11.4883  1
1997 Bonini JA, Steiner DF. Molecular cloning and expression of a novel rat CC-chemokine receptor (rCCR10rR) that binds MCP-1 and MIP-1β with high affinity Dna and Cell Biology. 16: 1023-1030. PMID 9324304  1
1997 Steiner DF, Rubenstein AH. Proinsulin C-peptide-biological activity? Science. 277: 531-532. PMID 9254422 DOI: 10.1126/science.277.5325.531  1
1997 Furuta M, Yano H, Zhou A, Rouillé Y, Holst JJ, Carroll R, Ravazzola M, Orci L, Furuta H, Steiner DF. Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2 Proceedings of the National Academy of Sciences of the United States of America. 94: 6646-6651. PMID 9192619 DOI: 10.1073/pnas.94.13.6646  1
1997 Bonini JA, Anderson SM, Steiner DF. Molecular cloning and tissue expression of a novel orphan G protein-coupled receptor from rat lung Biochemical and Biophysical Research Communications. 234: 190-193. PMID 9168987 DOI: 10.1006/bbrc.1997.6591  1
1997 Kaiser N, Bailyes EM, Schneider BS, Cerasi E, Steiner DF, Hutton JC, Gross DJ. Characterization of the unusual insulin of Psammomys obesus, a rodent with nutrition-induced NIDDM-like syndrome. Diabetes. 46: 953-7. PMID 9166665  1
1997 Kristensen C, Kjeldsen T, Wiberg FC, Schäffer L, Hach M, Havelund S, Bass J, Steiner DF, Andersen AS. Alanine scanning mutagenesis of insulin Journal of Biological Chemistry. 272: 12978-12983. PMID 9148904 DOI: 10.1074/jbc.272.20.12978  1
1997 Pittman I, Nakagawa SH, Tager HS, Steiner DF. Maintenance of the B-chain beta-turn in [GlyB24] insulin mutants: a steady-state fluorescence anisotropy study. Biochemistry. 36: 3430-7. PMID 9131992 DOI: 10.1021/bi9624144  1
1997 LaMendola J, Martin SK, Steiner DF. Expression of PC3, carboxypeptidase E and enkephalin in human monocyte-derived macrophages as a tool for genetic studies. Febs Letters. 404: 19-22. PMID 9074629 DOI: 10.1016/S0014-5793(97)00078-1  1
1997 Duguay SJ, Milewski WM, Young BD, Nakayama K, Steiner DF. Processing of wild-type and mutant proinsulin-like growth factor-IA by subtilisin-related proprotein convertases Journal of Biological Chemistry. 272: 6663-6670. PMID 9045697 DOI: 10.1074/jbc.272.10.6663  1
1997 Upton Z, Francis GL, Chan SJ, Steiner DF, Wallace JC, Ballard FJ. Evolution of insulin-like growth factor (IGF) function: Production and characterization of recombinant hagfish IGF General and Comparative Endocrinology. 105: 79-90. PMID 9000470 DOI: 10.1006/gcen.1996.6802  1
1996 Duguay SJ, Lai-Zhang J, Steiner DF, Funkenstein B, Chan SJ. Developmental and tissue-regulated expression of IGF-I and IGF-II mRNAs in sparus aurata Journal of Molecular Endocrinology. 16: 123-132. PMID 9156515  1
1996 Pashmforoush M, Chan SJ, Steiner DF. Structure and expression of the insulin-like peptide receptor from amphioxus Molecular Endocrinology. 10: 857-866. PMID 8813726 DOI: 10.1210/me.10.7.857  1
1996 Steiner DF, Rouillé Y, Gong Q, Martin S, Carroll R, Chan SJ. The role of prohormone convertases in insulin biosynthesis : Evidence for inherited defects in their action in man and experimental animals Diabetes and Metabolism. 22: 94-104. PMID 8792089  1
1996 Bass J, Kurose T, Pashmforoush M, Steiner DF. Fusion of insulin receptor ectodomains to immunoglobulin constant domains reproduces high-affinity insulin binding in vitro Journal of Biological Chemistry. 271: 19367-19375. PMID 8702623 DOI: 10.1074/jbc.271.32.19367  1
1996 Zhu X, Rouille Y, Lamango NS, Steiner DF, Lindberg I. Internal cleavage of the inhibitory 7B2 carboxyl-terminal peptide by PC2: A potential mechanism for its inactivation Proceedings of the National Academy of Sciences of the United States of America. 93: 4919-4924. PMID 8643504 DOI: 10.1073/pnas.93.10.4919  1
1996 Westermark P, Li ZC, Westermark GT, Leckström A, Steiner DF. Effects of beta cell granule components on human islet amyloid polypeptide fibril formation. Febs Letters. 379: 203-6. PMID 8603689 DOI: 10.1016/0014-5793(95)01512-4  1
1996 Kimura N, Ishikawa T, Sasaki Y, Sasano N, Onodera K, Shimizu Y, Kimura I, Steiner DF, Nagura H. Expression of prohormone convertase, PC2, in adrenocorticotropin-producing thymic carcinoid with elevated plasma corticotropin-releasing hormone Journal of Clinical Endocrinology and Metabolism. 81: 390-395. PMID 8550783 DOI: 10.1210/jc.81.1.390  1
1995 Rouillé Y, Duguay SJ, Lund K, Furuta M, Gong Q, Lipkind G, Oliva AA, Chan SJ, Steiner DF. Proteolytic Processing Mechanisms in the Biosynthesis of Neuroendocrine Peptides: The Subtilisin-like Proprotein Convertases Frontiers in Neuroendocrinology. 16: 322-361. PMID 8557169 DOI: 10.1006/frne.1995.1012  1
1995 Westermark G, Arora MB, Fox N, Carroll R, Chan SJ, Westermark P, Steiner DF. Amyloid formation in response to beta cell stress occurs in vitro, but not in vivo, in islets of transgenic mice expressing human islet amyloid polypeptide. Molecular Medicine (Cambridge, Mass.). 1: 542-53. PMID 8529120  1
1995 Scopsi L, Gullo M, Rilke F, Martin S, Steiner DF. Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues: Their use as markers of neuroendocrine differentiation Journal of Clinical Endocrinology and Metabolism. 80: 294-301. PMID 7829629  1
1995 Lipkind G, Gong Q, Steiner DF. Molecular modeling of the substrate specificity of prohormone convertases SPC2 and SPC3 Journal of Biological Chemistry. 270: 13277-13284. PMID 7768927 DOI: 10.1074/jbc.270.22.13277  1
1995 Oliva AA, Steiner DF, Shu Jin Chan. Proprotein convertases in amphioxus: Predicted structure and expression of proteases SPC2 and SPC3 Proceedings of the National Academy of Sciences of the United States of America. 92: 3591-3595. PMID 7724604  1
1995 Philipson LH, Steiner DF. Pas de deux or more: The sulfonylurea receptor and K+ channels Science. 268: 372-373. PMID 7716539  1
1995 Naggert JK, Fricker LD, Varlamov O, Nishina PM, Rouille Y, Steiner DF, Carroll RJ, Paigen BJ, Leiter EH. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity Nature Genetics. 10: 135-142. PMID 7663508 DOI: 10.1038/ng0695-135  1
1995 Duguay SJ, Lai-Zhang J, Steiner DF. Mutational analysis of the insulin-like growth factor I prohormone processing site Journal of Biological Chemistry. 270: 17566-17574. PMID 7615562 DOI: 10.1074/jbc.270.29.17566  1
1995 Vincent MT, Carroll RJ, Hammer RE, Chan SJ, Guz Y, Steiner DF, Teitelman G. A transgene coding for a human insulin analog has a mitogenic effect on murine embryonic β cells Proceedings of the National Academy of Sciences of the United States of America. 92: 6239-6243. PMID 7603977 DOI: 10.1073/pnas.92.14.6239  1
1995 Rouille Y, Martin S, Steiner DF. Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide Journal of Biological Chemistry. 270: 26488-26496. PMID 7592866 DOI: 10.1074/jbc.270.44.26488  1
1995 Dai G, Smeekens SP, Steiner DF, McMurtry JP, Kwok SC. Characterization of multiple prohormone convertase PC1/3 transcripts in porcine ovary. Biochimica Et Biophysica Acta. 1264: 1-6. PMID 7578241 DOI: 10.1016/0167-4781(95)00111-S  1
1995 Duguay SJ, Chan SJ, Mommsen TP, Steiner DF. Divergence of insulin-like growth factors I and II in the elasmobranch, Squalus acanthias. Febs Letters. 371: 69-72. PMID 7545136 DOI: 10.1016/0014-5793(95)00879-E  1
1994 Rouillé Y, Westermark G, Martin SK, Steiner DF. Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 3242-6. PMID 8159732  1
1994 Qian F, Chan SJ, Achkar C, Steiner DF, Frankfater A. Transcriptional regulation of cathepsin B expression in B16 melanomas of varying metastatic potential Biochemical and Biophysical Research Communications. 202: 429-436. PMID 8037744 DOI: 10.1006/bbrc.1994.1946  1
1994 Zigman JM, Westermark GT, LaMendola J, Steiner DF. Expression of cone transducin, Gz alpha, and other G-protein alpha-subunit messenger ribonucleic acids in pancreatic islets. Endocrinology. 135: 31-7. PMID 8013366 DOI: 10.1210/endo.135.1.8013366  1
1994 Kurose T, Pashmforoush M, Yoshimasa Y, Carroll R, Schwartz GP, Burke GT, Katsoyannis PG, Steiner DF. Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the α-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor Journal of Biological Chemistry. 269: 29190-29197. PMID 7961885  1
1994 Fan L, Westermark G, Chan SJ, Steiner DF. Altered gene structure and tissue expression of islet amyloid polypeptide in the chicken Molecular Endocrinology. 8: 713-721. PMID 7935487 DOI: 10.1210/me.8.6.713  1
1994 Hanabusa T, Ohagi S, LaMendola J, Chan SJ, Steiner DF. Nucleotide sequence and analysis of the mouse SPC3 promoter region Febs Letters. 356: 339-341. PMID 7805868 DOI: 10.1016/0014-5793(94)01285-7  1
1994 Martin SK, Carroll R, Benig M, Steiner DF. Regulation by glucose of the biosynthesis of PC2, PC3 and proinsulin in (ob/ob) mouse islets of Langerhans. Febs Letters. 356: 279-82. PMID 7805854 DOI: 10.1016/0014-5793(94)01284-9  1
1994 Pashmforoush M, Yoshimasa Y, Steiner DF. Exon 11 enhances insulin binding affinity and tyrosine kinase activity of the human insulin proreceptor Journal of Biological Chemistry. 269: 32639-32648. PMID 7798270  1
1994 Chan SJ, Steiner DF. 7 Structure and Expression of Insulinlike Growth Factor Genes in Fish Fish Physiology. 13: 213-224. DOI: 10.1016/S1546-5098(08)60068-0  1
1994 Chu YC, Thompson Burke G, Gammeltoft S, Chan SJ, Steiner DF, Katsoyannis PG. High-potency hybrid compounds related to insulin and amphioxus insulin-like peptide Biochemistry. 33: 13087-13092.  1
1993 Fox N, Schrementi J, Nishi M, Ohagi S, Chan SJ, Heisserman JA, Westermark GT, Leckström A, Westermark P, Steiner DF. Human islet amyloid polypeptide transgenic mice as a model of non-insulin-dependent diabetes mellitus (NIDDM). Febs Letters. 323: 40-4. PMID 8495745 DOI: 10.1016/0014-5793(93)81444-5  1
1993 Gong Q, Shu Jin Chan, Bajkowski AS, Steiner DF, Frankfater A. Characterization of the cathepsin B gene and multiple mRNAs in human tissues: Evidence for alternative splicing of cathepsin B pre-mRNA Dna and Cell Biology. 12: 299-309. PMID 8494608  1
1993 Steiner DF, Fox N, Smeekens SP, Ohagi S, Westermark G, Chan SJ. New molecular perspectives in islet hormone biosynthesis Biochemical Society Transactions. 21: 139-142. PMID 8449279  1
1993 Fan L, Gardner P, Shu Jin Chan, Steiner DF. Cloning and analysis of the gene encoding hummingbird proinsulin General and Comparative Endocrinology. 91: 25-30. PMID 8405887 DOI: 10.1006/gcen.1993.1100  1
1993 Madsen OD, Karlsen C, Nielsen E, Lund K, Kofod H, Welinder B, Rehfeld JF, Larsson LI, Steiner DF, Holst JJ, Michelsen BK. The dissociation of tumor-induced weight loss from hypoglycemia in a transplantable pluripotent rat islet tumor results in the segregation of stable α- and β-cell tumor phenotypes Endocrinology. 133: 2022-2030. PMID 8404649  1
1993 Kavsan VM, Koval AP, Grebenjuk VA, Chan SJ, Steiner DF, Roberts CT, LeRoith D. Structure of the chum salmon insulin-like growth factor I gene Dna and Cell Biology. 12: 729-737. PMID 8397830  1
1993 Seo T, Hanabusa T, Ohagi S, Steiner DF, Bell GI. Dinucleotide repeat polymorphism in the NEC2 gene Human Molecular Genetics. 2: 1983. PMID 8281173  1
1993 Oohashi H, Ohgawara H, Nanjo K, Tasaka Y, Cao QP, Shu Jin Chan, Rubenstein AH, Steiner DF, Omori Y. Familial hyperproinsulinemia associated with NIDDM: A case study Diabetes Care. 16: 1340-1346. PMID 8269791  1
1993 Zigman JM, Westermark GT, LaMendola J, Boel E, Steiner DF. Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system. Endocrinology. 133: 2508-14. PMID 8243272 DOI: 10.1210/endo.133.6.8243272  1
1993 Upton Z, Chan SJ, Steiner DF, Wallace JC, Ballard FJ. Characterization, structures, functional studies: Evolution of Insulin-like groth factor binding proteins Growth Regulation. 3: 29-32. PMID 7683521  1
1993 Herold KC, Nagamatsu S, Buse JB, Kulsakdinun P, Steiner DF. Inhibition of glucose-stimulated insulin release from βTC3 cells and rodent islets by an analog of FK506 Transplantation. 55: 186-192. PMID 7678356  1
1992 Nagamatsu S, Steiner DF. Altered glucose regulation of insulin biosynthesis in insulinoma cells: Mouse βTC3 cells secrete insulin-related peptides predominantly via a constitutive pathway Endocrinology. 130: 748-754. PMID 1733723 DOI: 10.1210/en.130.2.748  1
1992 Bailyes EM, Shennan IJ, Seal AJ, Smeekens SP, Steiner DF, Hutton JC, Docherty K. A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase Biochemical Journal. 285: 391-394. PMID 1637332  1
1992 Ohagi S, LaMendola J, LeBeau MM, Espinosa R, Takeda J, Smeekens SP, Chan SJ, Steiner DF. Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues Proceedings of the National Academy of Sciences of the United States of America. 89: 4977-4981. PMID 1594602  1
1992 Nagamatsu S, Nishi M, Steiner DF. Effects of islet amyloid polypeptide (IAPP) on insulin biosynthesis or secretion in rat islets and mouse βTC3 cells. Biosynthesis of IAPP in mouse βTC3 cells Diabetes Research and Clinical Practice. 15: 49-55. PMID 1541235 DOI: 10.1016/0168-8227(92)90067-2  1
1992 Smeekens SP, Montag AG, Thomas G, Albiges-Rizo C, Carroll R, Benig M, Phillips LA, Martin S, Ohagi S, Gardner P. Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3. Proceedings of the National Academy of Sciences of the United States of America. 89: 8822-6. PMID 1528899  1
1992 Shu Jin Chan, Oliva AA, LaMendola J, Grens A, Bode H, Steiner DF. Conservation of the prohormone convertase gene family in metazoa: Analysis of cDNAs encoding a PC3-like protein from hydra Proceedings of the National Academy of Sciences of the United States of America. 89: 6678-6682. PMID 1495957 DOI: 10.1073/pnas.89.15.6678  1
1992 Steiner DF, James DE. Cellular and molecular biology of the Beta cell Diabetologia. 35: S41-S48. PMID 1478377 DOI: 10.1007/BF00586278  1
1992 Steiner DF, Smeekens SP, Ohagi S, Shu Jin Chan. The new enzymology of precursor processing endoproteases Journal of Biological Chemistry. 267: 23435-23438. PMID 1429684  1
1992 Nishi M, Sanke T, Ohagi S, Ekawa K, Wakasaki H, Nanjo K, Bell GI, Steiner dF. Molecular biology of islet amyloid polypeptide Diabetes Research and Clinical Practice. 15: 37-44. PMID 1371737 DOI: 10.1016/0168-8227(92)90065-Y  1
1992 Smeekens SP, Chan SJ, Steiner DF. The biosynthesis and processing of neuroendocrine peptides: Identification of proprotein convertases involved in intravesicular processing Progress in Brain Research. 92: 235-246. PMID 1302878  1
1992 Chan SJ, Nagamatsu S, Cao QP, Steiner DF. Structure and evolution of insulin and insulin-like growth factors in chordates Progress in Brain Research. 92: 15-24. PMID 1302874  1
1991 Shennan KIJ, Smeekens SP, Steiner DF, Docherty K. Characterization of PC2, a mammalian Kex2 homologue, following expression of the cDNA in microinjected Xenopus oocytes Febs Letters. 284: 277-280. PMID 2060650 DOI: 10.1016/0014-5793(91)80703-6  1
1991 Qian F, Frankfater A, Chan SJ, Steiner DF. The structure of the mouse cathepsin B gene and its putative promoter Dna and Cell Biology. 10: 159-168. PMID 2012677  1
1991 Steiner DF, Ohagi S, Nagamatsu S, Bell GI, Nishi M. Is islet amyloid polypeptide a significant factor in pathogenesis or pathophysiology of diabetes? Diabetes. 40: 305-309. PMID 1999269  1
1991 Nagamatsu S, Chan SJ, Falkmer S, Steiner DF. Evolution of the insulin gene superfamily: Sequence of a preproinsulin-like growth factor cDNA from the atlantic hagfish Journal of Biological Chemistry. 266: 2397-2402. PMID 1989990  1
1991 Smeekens SP, Avruch AS, LaMendola J, Chan SJ, Steiner DF. Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans Proceedings of the National Academy of Sciences of the United States of America. 88: 340-344. PMID 1988934 DOI: 10.1073/pnas.88.2.340  1
1991 Philipson LH, Hice RE, Schaefer K, Lamendola J, Bell GI, Nelson DJ, Steiner DF. Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel Proceedings of the National Academy of Sciences of the United States of America. 88: 53-57. PMID 1986382  1
1991 Nagamatsu S, Nishi M, Steiner DF. Biosynthesis of islet amyloid polypeptide: Elevated expression in mouse βTC3 cells Journal of Biological Chemistry. 266: 13737-13741. PMID 1856207  1
1991 Madsen OD, Nielsen JH, Michelsen B, Westermark P, Betsholtz C, Nishi M, Steiner DF. Islet amyloid polypeptide and insulin expression are controlled differently in primary and transformed islet cells. Molecular Endocrinology (Baltimore, Md.). 5: 143-8. PMID 1850107 DOI: 10.1210/mend-5-1-143  1
1991 Qian F, Chan SJ, Gong Q, Bajkowski AS, Steiner DF, Frankfater A. The expression of cathepsin B and other lysosomal proteinases in normal tissues and in tumors Biomedica Biochimica Acta. 50: 531-540. PMID 1801719  1
1991 Shennan KIJ, Seal AJ, Smeekens SP, Steiner DF, Docherty K. Site-directed mutagenesis and expression of PC2 in microinjected Xenopus oocytes Journal of Biological Chemistry. 266: 24011-24017. PMID 1748673  1
1991 Qian F, Frankfater A, Steiner DF, Bajkowski AS, Chan SJ. Characterization of multiple cathepsin B mRNAs in murine B16a melanoma Anticancer Research. 11: 1445-1451. PMID 1746902  1
1991 Smeekens SP, Steiner DF. Processing of peptide precursors - Identification of a new family of mammalian proteases Cell Biophysics. 19: 45-55. PMID 1726887 DOI: 10.1007/BF02989878  1
1991 Ohagi S, Nishi M, Bell GI, Ensinck JW, Steiner DF. Sequences of islet amyloid polypeptide precursors of an old world monkey, the pig-tailed macaque (Macaca nemestrina), and the dog (Canis familiaris) Diabetologia. 34: 555-558. PMID 1718805 DOI: 10.1007/BF00400272  1
1991 Thomas L, Leduc R, Thorne BA, Smeekens SP, Steiner DF, Thomas G. Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: Evidence for a common core of neuroendocrine processing enzymes Proceedings of the National Academy of Sciences of the United States of America. 88: 5297-5301. PMID 1647029  1
1991 Steiner DF. Prohormone convertases revealed at last Current Biology. 1: 375-377. DOI: 10.1016/0960-9822(91)90198-6  1
1990 Nishi M, Sanke T, Nagamatsu S, Bell GI, Steiner DF. Islet amyloid polypeptide. A new β cell secretory product related to islet amyloid deposits Journal of Biological Chemistry. 265: 4173-4176. PMID 2407732  1
1990 Nishi M, Steiner DF. Cloning of complementary DNAs encoding islet amyloid polypeptide, insulin, and glucagon precursors from a new world rodent, the degu, Octodon degus Molecular Endocrinology. 4: 1192-1198. PMID 2293024  1
1990 Philipson LH, Schaefer K, LaMendola J, Bell GI, Steiner DF. Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4 Nucleic Acids Research. 18: 7160. PMID 2263489 DOI: 10.1093/nar/18.23.7160  1
1990 Nishi M, Bell GI, Steiner DF. Islet amyloid polypeptide (amylin): no evidence of an abnormal precursor sequence in 25 Type 2 (non-insulin-dependent) diabetic patients Diabetologia. 33: 628-630. PMID 2258001 DOI: 10.1007/BF00400208  1
1990 Nishi M, Bell GI, Steiner DF. Sequence of a cDNA encoding Syrian hamster islet amyloid polypeptide precursor Nucleic Acids Research. 18: 6726. PMID 2251153  1
1990 Yoshimasa Y, Paul JI, Whittaker J, Steiner DF. Effects of amino acid replacements within the tetrabasic cleavage site on the processing of the human insulin receptor precursor expressed in Chinese hamster ovary cells Journal of Biological Chemistry. 265: 17230-17237. PMID 2211623  1
1990 Paul JI, Tavaré J, Denton RM, Steiner DF. Baculovirus-directed expression of the human insulin receptor and an insulin-binding ectodomain. The Journal of Biological Chemistry. 265: 13074-83. PMID 2198283  1
1990 Steiner DF, Tager HS, Chan SJ, Nanjo K, Sanke T, Rubenstein AH. Lessons learned from molecular biology of insulin-gene mutations. Diabetes Care. 13: 600-9. PMID 2192846  1
1990 Nagamatsu S, Carroll RJ, Grodsky GM, Steiner DF. Lack of islet amyloid polypeptide regulation of insulin biosynthesis or secretion in normal rat islets Diabetes. 39: 871-874. PMID 2191889  1
1990 Ohagi S, Nishi M, Steiner DF. Sequence of a cDNA encoding human LRP (leukocyte common antigen-related peptide) Nucleic Acids Research. 18: 7159. PMID 2175890  1
1990 Nishi M, Ohagi S, Steiner DF. Novel putative protein tyrosine phosphatases identified by the polymerase chain reaction Febs Letters. 271: 178-180. PMID 2171999 DOI: 10.1016/0014-5793(90)80400-D  1
1990 Smeekens SP, Steiner DF. Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2 Journal of Biological Chemistry. 265: 2997-3000. PMID 2154467  1
1990 Shu Jin Chan, Cao QP, Steiner DF. Evolution of the insulin superfamily: Cloning of a hybrid insulin/insulin-like growth factor cDNA from amphioxus Proceedings of the National Academy of Sciences of the United States of America. 87: 9319-9323. PMID 1701257 DOI: 10.1073/pnas.87.23.9319  1
1986 Steiner DF, Chan SJ, Welsh JM, Nielsen D, Michael J, Tager HS, Rubenstein AH. Models of peptide biosynthesis: the molecular and cellular basis of insulin production. Clinical and Investigative Medicine. MéDecine Clinique Et Experimentale. 9: 328-36. PMID 3542328  1
1984 Naithani VK, Steffens GJ, Tager HS, Buse G, Rubenstein AH, Steiner DF. Isolation and amino-acid sequence determination of monkey insulin and proinsulin. Hoppe-Seyler's Zeitschrift FüR Physiologische Chemie. 365: 571-5. PMID 6381277  1
1983 Kwok SC, Steiner DF, Rubenstein AH, Tager HS. Identification of a point mutation in the human insulin gene giving rise to a structurally abnormal insulin (insulin Chicago). Diabetes. 32: 872-5. PMID 6313457  1
1981 Tager HS, Steiner DF, Patzelt C. Biosynthesis of insulin and glucagon. Methods in Cell Biology. 23: 73-88. PMID 7035811  1
1980 Steiner DF, Quinn PS, Chan SJ, Marsh J, Tager HS. Processing mechanisms in the biosynthesis of proteins. Annals of the New York Academy of Sciences. 343: 1-16. PMID 6994549  1
1980 Patzelt C, Tager HS, Carroll RJ, Steiner DF. Identification of prosomatostatin in pancreatic islets. Proceedings of the National Academy of Sciences of the United States of America. 77: 2410-4. PMID 6771754  1
1980 Pilkis SJ, El-Maghrabi MR, Coven B, Claus TH, Tager HS, Steiner DF, Keim PS, Heinrikson RL. Phosphorylation of rat hepatic fructose-1,6-bisphosphatase and pyruvate kinase. The Journal of Biological Chemistry. 255: 2770-5. PMID 6244292  1
1980 Patzelt C, Neilsen D, Carroll R, Quinn P, Lernmark A, Tager HS, Steiner DF. Studies on the biosynthesis of the other peptide hormones of the rat islets of Langerhans. Biochemical Society Transactions. 8: 411-3. PMID 6108881  1
1980 Steiner DF, Patzelt C, Chan SJ, Quinn PS, Tager HS, Nielsen D, Lernmark A, Noyes BE, Agarwal KL, Gabbay KH, Rubenstein AH. Formation of biologically active peptides. Proceedings of the Royal Society of London. Series B, Biological Sciences. 210: 45-59. PMID 6107930  1
1980 Tager HS, Patzelt C, Assoian RK, Chan SJ, Duguid JR, Steiner DF. Biosynthesis of islet cell hormones. Annals of the New York Academy of Sciences. 343: 133-47. PMID 6104939  1
1979 Patzelt C, Tager HS, Carroll RJ, Steiner DF. Identification and processing of proglucagon in pancreatic islets. Nature. 282: 260-6. PMID 388230  1
1976 Lernmark A, Chan SJ, Choy R, Nathans A, Carroll R, Tager HS, Rubenstein AH, Swift HH, Steiner DF. Biosynthesis of insulin and glucagon: a view of the current state of the art. Ciba Foundation Symposium. 41: 7-30. PMID 780079  1
1975 Tager HS, Rubenstein AH, Steiner DF. Methods for the assessment of peptide precursors. Studies insulin biosynthesis. Methods in Enzymology. 37: 326-45. PMID 1092957  1
1974 Steiner DF, Kemmler W, Tager HS, Rubenstein AH. Molecular events taking place during intracellular transport of exportable proteins. The conversion of peptide hormone precursors. Advances in Cytopharmacology. 2: 195-205. PMID 4613155  1
1974 Steiner DF, Kemmler W, Tager HS, Peterson JD. Proteolytic processing in the biosynthesis of insulin and other proteins. Federation Proceedings. 33: 2105-15. PMID 4370934  1
1974 Tager HS, Steiner DF. Peptide hormones. Annual Review of Biochemistry. 43: 509-38. PMID 4368999 DOI: 10.1146/annurev.bi.43.070174.002453  1
1973 Tager HS, Emdin SO, Clark JL, Steiner DF. Studies on the conversion of proinsulin to insulin. II. Evidence for a chymotrypsin-like cleavage in the connecting peptide region of insulin precursors in the rat. The Journal of Biological Chemistry. 248: 3476-82. PMID 4573980  1
1973 Tager HS, Steiner DF. Isolation of a glucagon-containing peptide: primary structure of a possible fragment of proglucagon. Proceedings of the National Academy of Sciences of the United States of America. 70: 2321-5. PMID 4525166  1
1972 Tager HS, Steiner DF. Primary structures of the proinsulin connecting peptides of the rat and the horse. The Journal of Biological Chemistry. 247: 7936-40. PMID 4640931  1
1956 Steiner DF, Anker HS. ON THE SYNTHESIS OF ANTIBODY PROTEIN IN VITRO. Proceedings of the National Academy of Sciences of the United States of America. 42: 580-6. PMID 16589910  1
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