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Alexandra C. Newton, PhD - Publications

Affiliations: 
1988-1995 Chemistry Indiana University, Bloomington, Bloomington, IN, United States 
 1995- Pharmacology University of California, San Diego, La Jolla, CA 
Area:
Protein kinase C
Website:
https://profiles.ucsd.edu/alexandra.newton
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208 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kennedy PH, Deh Sheikh AA, Balakar M, Jones AC, Olive ME, Hegde M, Matias MI, Pirete N, Burt R, Levy J, Little T, Hogan PG, Liu DR, Doench JG, Newton AC, et al. Proteome-wide base editor screens to assess phosphorylation site functionality in high-throughput. Biorxiv : the Preprint Server For Biology. PMID 38014346 DOI: 10.1101/2023.11.11.566649  0.314
2023 Jones AC, Kornev AP, Weng JH, Manning G, Taylor S, Newton AC. Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration. The Biochemical Journal. PMID 37551632 DOI: 10.1042/BCJ20220397  0.333
2023 Jones AC, Kornev AP, Weng JH, Manning G, Taylor SS, Newton AC. Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration. Biorxiv : the Preprint Server For Biology. PMID 36993163 DOI: 10.1101/2023.03.16.532226  0.333
2023 Newton AC, Alessi DR. Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer. Iubmb Life. 75: 282-283. PMID 36905647 DOI: 10.1002/iub.2715  0.344
2023 Tovell H, Newton AC. Protein kinase C showcases allosteric control: activation of LRRK1. The Biochemical Journal. 480: 219-223. PMID 36762701 DOI: 10.1042/BCJ20220507  0.574
2022 Pilo CA, Baffi TR, Kornev AP, Kunkel MT, Malfavon M, Chen DH, Rossitto LA, Chen DX, Huang LC, Longman C, Kannan N, Raskind WH, Gonzalez DJ, Taylor SS, Gorrie G, ... Newton AC, et al. Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition. Science Signaling. 15: eabk1147. PMID 36166510 DOI: 10.1126/scisignal.abk1147  0.822
2022 Pilo CA, Newton AC. Two Sides of the Same Coin: Protein Kinase C γ in Cancer and Neurodegeneration. Frontiers in Cell and Developmental Biology. 10: 929510. PMID 35800893 DOI: 10.3389/fcell.2022.929510  0.845
2022 Baffi TR, Newton AC. Protein kinase C: release from quarantine by mTORC2. Trends in Biochemical Sciences. PMID 35361526 DOI: 10.1016/j.tibs.2022.03.003  0.873
2021 Lordén G, Newton AC. Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment? Neuronal Signaling. 5: NS20210036. PMID 34737895 DOI: 10.1042/NS20210036  0.451
2021 Baffi TR, Newton AC. . Molecular Pharmacology. PMID 34155089 DOI: 10.1124/molpharm.121.000310  0.878
2021 Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, ... ... Newton AC, et al. mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Science Signaling. 14. PMID 33850054 DOI: 10.1126/scisignal.abe4509  0.866
2021 Van AN, Kunkel MT, Baffi TR, Lordén G, Antal CE, Banerjee S, Newton AC. Protein kinase C fusion proteins are paradoxically loss-of-function in cancer. The Journal of Biological Chemistry. 100445. PMID 33617877 DOI: 10.1016/j.jbc.2021.100445  0.846
2021 Tovell H, Newton AC. PHLPPing the balance: restoration of protein kinase C in cancer. The Biochemical Journal. 478: 341-355. PMID 33502516 DOI: 10.1042/BCJ20190765  0.454
2021 Kawashima AT, Wong C, Lordén G, King CC, Lara-Gonzalez P, Desai A, Gingras AC, Newton AC. The PHLPP1 N-Terminal Extension is a Mitotic Cdk1 Substrate and Controls an Interactome Switch. Molecular and Cellular Biology. PMID 33397691 DOI: 10.1128/MCB.00333-20  0.44
2020 Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J. Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus. Nature Communications. 11: 6088. PMID 33257668 DOI: 10.1038/s41467-020-19937-w  0.309
2020 Jones AC, Taylor SS, Newton AC, Kornev AP. Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes. Iubmb Life. PMID 33166426 DOI: 10.1002/iub.2401  0.425
2020 Baffi TR, Katsenelson KC, Newton AC. PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling. Annual Review of Pharmacology and Toxicology. PMID 32997603 DOI: 10.1146/annurev-pharmtox-031820-122108  0.837
2020 Kawashima AT, Newton AC. Pharmacology on Target. Trends in Pharmacological Sciences. 41: 227-230. PMID 32122673 DOI: 10.1016/J.Tips.2020.02.002  0.449
2020 Lorden G, Wosniak JM, Dozier LE, Patrick GN, Gonzalez DJ, Roberts AJ, Newton AC. Amplified Protein Kinase C Signaling in Alzheimer's Disease The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06842  0.505
2020 Jones AC, Newton AC. Recognition Motif of Protein Kinase C and Protein Phosphatase 2A The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05897  0.505
2020 Kawashima AG, Wong C, King CC, Gingras A, Newton A. CDK1‐dependent Phosphorylation of the Tumor Suppressor Phosphatase, PHLPP1, Regulates the Mitotic PHLPP1 Interactome The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05501  0.431
2020 Van AN, Kunkel MT, Baffi TR, Antal CE, Newton AC. Protein Kinase C Fusions Reveal Another Mechanism for Loss of Protein Kinase C Function in Cancer The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05363  0.858
2020 Zhou X, Zhong Y, Kunkel MT, Newton AC, Zhang J. Tracking mTORC1 Activity in the Nucleus: Distinct Regulation Revealed by Locationspecific Inhibition of Akt The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04692  0.374
2020 Pilo CA, Kunkel MT, Van AN, Kobori EK, Kornev AP, Longman C, Gorrie G, Taylor SS, Newton AC. Impaired Autoinhibition of Protein Kinase Cγ in Spinocerebellar Ataxia Type 14 Biophysical Journal. 118: 535a. DOI: 10.1096/Fasebj.2020.34.S1.04177  0.525
2020 Kajimoto T, Caliman AD, Tobias IS, Okada T, Pilo CA, Van AN, McCammon JA, Nakamura S, Newton AC. A new molecular mechanism of evasion of apoptosis revealed by novel C‐kinase activity reporter The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03250  0.763
2019 Cohen Katsenelson K, Stender JD, Kawashima AT, Lordén G, Uchiyama S, Nizet V, Glass CK, Newton AC. PHLPP1 counter-regulates STAT1-mediated inflammatory signaling. Elife. 8. PMID 31408005 DOI: 10.7554/Elife.48609  0.38
2019 Nowak DG, Katsenelson KC, Watrud KE, Chen M, Mathew G, D'Andrea VD, Lee MF, Swamynathan MM, Casanova-Salas I, Jibilian MC, Buckholtz CL, Ambrico AJ, Pan CH, Wilkinson JE, Newton AC, et al. The PHLPP2 phosphatase is a druggable driver of prostate cancer progression. The Journal of Cell Biology. PMID 31092557 DOI: 10.1083/Jcb.201902048  0.319
2019 Newton AC. Protein kinases in tune. Iubmb Life. PMID 31059207 DOI: 10.1002/Iub.2065  0.572
2019 Baffi TR, Van AN, Zhao W, Mills GB, Newton AC. Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer. Molecular Cell. PMID 30904392 DOI: 10.1016/J.Molcel.2019.02.018  0.869
2019 Jung HY, Fattet L, Tsai JH, Kajimoto T, Chang Q, Newton AC, Yang J. Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation. Nature Cell Biology. PMID 30804505 DOI: 10.1038/S41556-019-0291-8  0.403
2019 Kajimoto T, Caliman AD, Tobias IS, Okada T, Pilo CA, Van AN, Andrew McCammon J, Nakamura SI, Newton AC. Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter. Science Signaling. 12. PMID 30600259 DOI: 10.1126/Scisignal.Aat6662  0.86
2019 Harper W, Newton AC, McPherson PS. Decision letter: PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins Elife. DOI: 10.7554/Elife.50416.038  0.366
2018 Callender JA, Yang Y, Lordén G, Stephenson NL, Jones AC, Brognard J, Newton AC. Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29844158 DOI: 10.1073/Pnas.1805046115  0.842
2018 Balasuriya N, Kunkel MT, Liu X, Biggar KK, Li SS, Newton AC, O'Donoghue P. Genetic code expansion and live cell imaging reveal that Thr308 phosphorylation is irreplaceable and sufficient for Akt1 activity. The Journal of Biological Chemistry. PMID 29773654 DOI: 10.1074/Jbc.Ra118.002357  0.547
2018 Huang LC, Ross KE, Baffi TR, Drabkin H, Kochut KJ, Ruan Z, D'Eustachio P, McSkimming D, Arighi C, Chen C, Natale DA, Smith C, Gaudet P, Newton AC, Wu C, et al. Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources. Scientific Reports. 8: 6518. PMID 29695735 DOI: 10.1038/S41598-018-24457-1  0.857
2018 Newton AC. Protein kinase C: perfectly balanced. Critical Reviews in Biochemistry and Molecular Biology. 53: 208-230. PMID 29513138 DOI: 10.1080/10409238.2018.1442408  0.587
2017 Callender JA, Newton AC. Conventional protein kinase C in the brain: 40 years later. Neuronal Signaling. 1: NS20160005. PMID 32714576 DOI: 10.1042/NS20160005  0.431
2017 Newton AC. Protein Kinase C as a Tumor Suppressor. Seminars in Cancer Biology. PMID 28476658 DOI: 10.1016/J.Semcancer.2017.04.017  0.513
2017 Newton AC, Brognard J. Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor. Trends in Pharmacological Sciences. PMID 28283201 DOI: 10.1016/J.Tips.2017.02.002  0.744
2017 Yang Y, Callender JA, Newton AC, Igumenova TI. Structural and Dynamical Basis of Protein Kinase C Alpha Regulation by the C-Terminal Tail Biophysical Journal. 112: 500a. DOI: 10.1016/J.Bpj.2016.11.2704  0.532
2016 Grzechnik AT, Newton AC. PHLPPing through history: a decade in the life of PHLPP phosphatases. Biochemical Society Transactions. 44: 1675-1682. PMID 27913677 DOI: 10.1042/Bst20160170  0.461
2016 McSkimming DI, Dastgheib S, Baffi TR, Byrne DP, Ferries S, Scott ST, Newton AC, Eyers CE, Kochut KJ, Eyers PA, Kannan N. KinView: a visual comparative sequence analysis tool for integrated kinome research. Molecular Biosystems. PMID 27731453 DOI: 10.1039/C6Mb00466K  0.838
2016 Newton AC, Antal CE, Steinberg SF. Protein kinase C mechanisms that contribute to cardiac remodelling. Clinical Science (London, England : 1979). 130: 1499-510. PMID 27433023 DOI: 10.1042/Cs20160036  0.841
2016 Scott JD, Newton AC. Bacterial spore coat protein kinases: A new twist to an old story. Proceedings of the National Academy of Sciences of the United States of America. PMID 27286827 DOI: 10.1073/Pnas.1607004113  0.575
2016 Hollands A, Corriden R, Gysler G, Dahesh S, Olson J, Ali SR, Kunkel MT, Lin AE, Forli S, Newton AC, Kumar GB, Nair BG, Perry JJ, Nizet V. Natural product anacardic acid from cashew nut shells stimulates neutrophil extracellular trap production and bactericidal activity. The Journal of Biological Chemistry. PMID 27226531 DOI: 10.1074/Jbc.M115.695866  0.328
2016 Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R. Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease. Science Signaling. 9: ra47. PMID 27165780 DOI: 10.1126/Scisignal.Aaf6209  0.758
2016 Newton AC, Tanzi RE, VanHook AM. Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer's disease. Science Signaling. 9: pc11. PMID 27165779 DOI: 10.1126/Scisignal.Aaf9436  0.337
2016 Tobias IS, Newton AC. Protein Scaffolds Control Localized Protein Kinase Cζ Activity. The Journal of Biological Chemistry. 291: 13809-22. PMID 27143478 DOI: 10.1074/Jbc.M116.729483  0.839
2016 Dowling CM, Phelan J, Callender JA, Cathcart MC, Mehigan B, McCormick P, Dalton T, Coffey JC, Newton AC, O'Sullivan J, Kiely PA. Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival. Oncotarget. PMID 26989024 DOI: 10.18632/Oncotarget.8062  0.4
2016 Dowling CM, Phelan J, Callender JA, Cathcart MC, Mehigan B, McCormick P, Dalton T, Coffey JC, Newton AC, O’Sullivan J, Kiely PA. Abstract 1888: Protein kinase C beta II suppresses colorectal cancer by regulating IGF1 mediated cell survival Cancer Research. 76: 1888-1888. DOI: 10.1158/1538-7445.Am2016-1888  0.417
2015 Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy SF, King CC, Newton AC. Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. The Biochemical Journal. PMID 26635352 DOI: 10.1042/Bj20151013  0.864
2015 Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII. Cell Reports. 12: 1252-60. PMID 26279568 DOI: 10.1016/J.Celrep.2015.07.039  0.835
2015 Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC. Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. The Journal of Biological Chemistry. PMID 26187466 DOI: 10.1074/Jbc.M115.676221  0.491
2015 Bradley EW, Carpio LR, Newton AC, Westendorf JJ. Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation. The Journal of Biological Chemistry. 290: 16272-80. PMID 25953896 DOI: 10.1074/Jbc.M114.612937  0.488
2015 Midde KK, Aznar N, Laederich MB, Ma GS, Kunkel MT, Newton AC, Ghosh P. Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors. Proceedings of the National Academy of Sciences of the United States of America. 112: E937-46. PMID 25713130 DOI: 10.1073/Pnas.1420140112  0.403
2015 Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell. 160: 489-502. PMID 25619690 DOI: 10.1016/J.Cell.2015.01.001  0.822
2015 Kunkel MT, Newton AC. Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation. Chemistry & Biology. 22: 98-106. PMID 25556943 DOI: 10.1016/J.Chembiol.2014.11.014  0.614
2015 Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller C, Furnari F, Hunter T, Brognard J, Newton AC. Abstract 125: Protein kinase C loss-of-function mutations in cancer reveal role as tumor suppressor Cancer Research. 75: 125-125. DOI: 10.1158/1538-7445.Am2015-125  0.83
2014 Antal CE, Newton AC. Tuning the signalling output of protein kinase C. Biochemical Society Transactions. 42: 1477-83. PMID 25399557 DOI: 10.1042/Bst20140172  0.824
2014 Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC. Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output. Proceedings of the National Academy of Sciences of the United States of America. 111: E3957-65. PMID 25201979 DOI: 10.1073/Pnas.1404221111  0.857
2014 Sierecki E, Newton AC. Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase. Biochemistry. 53: 3971-81. PMID 24892992 DOI: 10.1021/Bi500428J  0.547
2014 Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, et al. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Molecular Cell. 54: 378-91. PMID 24703948 DOI: 10.1016/J.Molcel.2014.03.007  0.533
2014 Antal CE, Violin JD, Kunkel MT, Skovsø S, Newton AC. Intramolecular conformational changes optimize protein kinase C signaling. Chemistry & Biology. 21: 459-69. PMID 24631122 DOI: 10.1016/J.Chembiol.2014.02.008  0.83
2014 Cone AC, Cavin G, Ambrosi C, Hakozaki H, Wu-Zhang AX, Kunkel MT, Newton AC, Sosinsky GE. Protein kinase Cδ-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation. The Journal of Biological Chemistry. 289: 8781-98. PMID 24500718 DOI: 10.1074/Jbc.M113.533265  0.871
2014 Newton AC, Trotman LC. Turning off AKT: PHLPP as a drug target. Annual Review of Pharmacology and Toxicology. 54: 537-58. PMID 24392697 DOI: 10.1146/Annurev-Pharmtox-011112-140338  0.576
2014 Kunkel MT, Newton AC. Imaging kinase activity at protein scaffolds. Methods in Molecular Biology (Clifton, N.J.). 1071: 129-37. PMID 24052385 DOI: 10.1007/978-1-62703-622-1_10  0.596
2014 Antal CE, Kang E, Stephenson NL, Trotter EW, Hunter T, Brognard J, Newton A. Abstract 5270: Prevalence of inactivating protein kinase C mutations in human cancers Cancer Research. 74: 5270-5270. DOI: 10.1158/1538-7445.Am2014-5270  0.839
2013 Antal CE, Newton AC. Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling. Molecular & Cellular Proteomics : McP. 12: 3498-508. PMID 23788531 DOI: 10.1074/Mcp.R113.029819  0.841
2013 Wu-Zhang AX, Newton AC. Protein kinase C pharmacology: refining the toolbox. The Biochemical Journal. 452: 195-209. PMID 23662807 DOI: 10.1042/Bj20130220  0.845
2013 Scott AM, Antal CE, Newton AC. Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα. The Journal of Biological Chemistry. 288: 16905-15. PMID 23589289 DOI: 10.1074/Jbc.M113.467456  0.826
2013 O'Neill AK, Niederst MJ, Newton AC. Suppression of survival signalling pathways by the phosphatase PHLPP. The Febs Journal. 280: 572-83. PMID 22340730 DOI: 10.1111/J.1742-4658.2012.08537.X  0.858
2012 Wu-Zhang AX, Murphy AN, Bachman M, Newton AC. Isozyme-specific interaction of protein kinase Cδ with mitochondria dissected using live cell fluorescence imaging. The Journal of Biological Chemistry. 287: 37891-906. PMID 22988234 DOI: 10.1074/Jbc.M112.412635  0.798
2012 de Lichtervelde L, Antal CE, Boitano AE, Wang Y, Krastel P, Petersen F, Newton AC, Cooke MP, Schultz PG. Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation. Chemistry & Biology. 19: 994-1000. PMID 22921066 DOI: 10.1016/J.Chembiol.2012.06.010  0.766
2012 Scott JD, Newton AC. Shedding light on local kinase activation. Bmc Biology. 10: 61. PMID 22805055 DOI: 10.1186/1741-7007-10-61  0.429
2012 Wu-Zhang AX, Schramm CL, Nabavi S, Malinow R, Newton AC. Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory. The Journal of Biological Chemistry. 287: 12879-85. PMID 22378786 DOI: 10.1074/Jbc.M112.357244  0.812
2012 Abrahamsen H, O'Neill AK, Kannan N, Kruse N, Taylor SS, Jennings PA, Newton AC. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. The Journal of Biological Chemistry. 287: 13262-78. PMID 22318721 DOI: 10.1074/Jbc.M112.349753  0.859
2012 O'Hayre M, Niederst M, Fecteau JF, Nguyen VM, Kipps TJ, Messmer D, Newton AC, Handel TM. Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL). Leukemia. 26: 1689-92. PMID 22237780 DOI: 10.1038/Leu.2012.6  0.8
2012 Warfel NA, Newton AC. Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling. The Journal of Biological Chemistry. 287: 3610-6. PMID 22144674 DOI: 10.1074/Jbc.R111.318675  0.826
2012 Cone A, Wu-Zhang A, Newton A, Sosinsky G. Spatio-Temporal Dissection of Protein Kinase C-Mediated Phosphorylation of the Gap Junction Protein Connexin43 Microscopy and Microanalysis. 18: 144-145. DOI: 10.1017/S1431927612002577  0.856
2011 O'Neill AK, Gallegos LL, Justilien V, Garcia EL, Leitges M, Fields AP, Hall RA, Newton AC. Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1). The Journal of Biological Chemistry. 286: 43559-68. PMID 22027822 DOI: 10.1074/Jbc.M111.294603  0.865
2011 Warfel NA, Niederst M, Newton AC. Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2. The Journal of Biological Chemistry. 286: 39122-9. PMID 21908613 DOI: 10.1074/Jbc.M111.278747  0.859
2011 Gallegos LL, Newton AC. Genetically encoded fluorescent reporters to visualize protein kinase C activation in live cells. Methods in Molecular Biology (Clifton, N.J.). 756: 295-310. PMID 21870234 DOI: 10.1007/978-1-61779-160-4_17  0.821
2011 Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A, Castillo-Martin M, Nowak DG, Naguib A, Grace DM, Murn J, Navin N, Atwal GS, Sander C, Gerald WL, ... ... Newton AC, et al. Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell. 20: 173-86. PMID 21840483 DOI: 10.1016/J.Ccr.2011.07.013  0.776
2011 Bossuyt J, Chang CW, Helmstadter K, Kunkel MT, Newton AC, Campbell KS, Martin JL, Bossuyt S, Robia SL, Bers DM. Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin. The Journal of Biological Chemistry. 286: 33390-400. PMID 21795686 DOI: 10.1074/Jbc.M111.246447  0.419
2011 Gould CM, Antal CE, Reyes G, Kunkel MT, Adams RA, Ziyar A, Riveros T, Newton AC. Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form Journal of Biological Chemistry. 286: 28922-28930. PMID 21715334 DOI: 10.1074/Jbc.M111.272526  0.869
2011 Keshwani MM, von Daake S, Newton AC, Harris TK, Taylor SS. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). The Journal of Biological Chemistry. 286: 23552-8. PMID 21561857 DOI: 10.1074/Jbc.M111.258004  0.631
2011 Patterson SJ, Han JM, Garcia R, Assi K, Gao T, O'Neill A, Newton AC, Levings MK. Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 186: 5533-7. PMID 21498666 DOI: 10.4049/Jimmunol.1002126  0.82
2011 Warfel NA, Niederst M, Stevens MW, Brennan PM, Frame MC, Newton AC. Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt Journal of Biological Chemistry. 286: 19777-19788. PMID 21454620 DOI: 10.1074/Jbc.M111.237081  0.804
2011 Xu Q, Fitzsimmons B, Steinauer J, O'Neill A, Newton AC, Hua XY, Yaksh TL. Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2113-24. PMID 21307248 DOI: 10.1523/Jneurosci.2139-10.2011  0.808
2011 O'Neill AK, Newton AC. PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) Atlas of Genetics and Cytogenetics in Oncology and Haematology. DOI: 10.4267/2042/44756  0.368
2011 Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A, Castillo-Martin M, Nowak DG, Naguib A, Grace DM, Murn J, Sander C, Gerald WL, Cordon-Cardo C, Newton AC, et al. Abstract 2405: Identification of PHLPP as a tumour suppressor reveals the role of pathway feedback compensation in PTEN-mutant prostate cancer progression Cancer Research. 71: 2405-2405. DOI: 10.1158/1538-7445.Am2011-2405  0.795
2010 Kajimoto T, Sawamura S, Tohyama Y, Mori Y, Newton AC. Protein kinase C {delta}-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases. The Journal of Biological Chemistry. 285: 41896-910. PMID 20959447 DOI: 10.1074/Jbc.M110.184028  0.609
2010 Sierecki E, Sinko W, McCammon JA, Newton AC. Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening. Journal of Medicinal Chemistry. 53: 6899-911. PMID 20836557 DOI: 10.1021/Jm100331D  0.474
2010 Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. PHLPP-1 negatively regulates Akt activity and survival in the heart. Circulation Research. 107: 476-84. PMID 20576936 DOI: 10.1161/Circresaha.109.215020  0.68
2010 Kunkel MT, Newton AC. Calcium transduces plasma membrane receptor signals to produce diacylglycerol at golgi membranes Journal of Biological Chemistry. 285: 22748-22752. PMID 20519514 DOI: 10.1074/Jbc.C110.123133  0.52
2010 Hoshi N, Langeberg LK, Gould CM, Newton AC, Scott JD. Interaction with AKAP79 modifies the cellular pharmacology of PKC. Molecular Cell. 37: 541-50. PMID 20188672 DOI: 10.1016/J.Molcel.2010.01.014  0.748
2010 Masubuchi S, Gao T, O'Neill A, Eckel-Mahan K, Newton AC, Sassone-Corsi P. Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proceedings of the National Academy of Sciences of the United States of America. 107: 1642-7. PMID 20080691 DOI: 10.1073/Pnas.0910292107  0.803
2010 Newton AC. Protein kinase C: poised to signal. American Journal of Physiology. Endocrinology and Metabolism. 298: E395-402. PMID 19934406 DOI: 10.1152/Ajpendo.00477.2009  0.594
2010 Patterson S, Garcia R, O'Neill A, Gao T, Newton A, Levings M. PHLPP Regulates the Development, Function and Molecular Signaling Pathways of T Regulatory Cells Clinical Immunology. 135: S6. DOI: 10.1016/J.Clim.2010.03.025  0.786
2009 Kunkel MT, Newton AC. Spatiotemporal Dynamics of Kinase Signaling Visualized by Targeted Reporters. Current Protocols in Chemical Biology. 1: 17-18. PMID 21804950 DOI: 10.1002/9780470559277.Ch090106  0.554
2009 Kunkel MT, Garcia EL, Kajimoto T, Hall RA, Newton AC. The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity. The Journal of Biological Chemistry. 284: 24653-61. PMID 19581308 DOI: 10.1074/Jbc.M109.024547  0.541
2009 Brognard J, Niederst M, Reyes G, Warfel N, Newton AC. Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. The Journal of Biological Chemistry. 284: 15215-23. PMID 19324870 DOI: 10.1074/Jbc.M901468200  0.865
2009 Gould CM, Kannan N, Taylor SS, Newton AC. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. The Journal of Biological Chemistry. 284: 4921-35. PMID 19091746 DOI: 10.1074/Jbc.M808436200  0.77
2009 Newton AC. Lipid activation of protein kinases. Journal of Lipid Research. 50: S266-71. PMID 19033211 DOI: 10.1194/Jlr.R800064-Jlr200  0.601
2008 Carnegie GK, Soughayer J, Smith FD, Pedroja BS, Zhang F, Diviani D, Bristow MR, Kunkel MT, Newton AC, Langeberg LK, Scott JD. AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Molecular Cell. 32: 169-79. PMID 18951085 DOI: 10.1016/J.Molcel.2008.08.030  0.52
2008 Gallegos LL, Newton AC. Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm. Iubmb Life. 60: 782-9. PMID 18720411 DOI: 10.1002/Iub.122  0.839
2008 Gould CM, Newton AC. The life and death of protein kinase C Current Drug Targets. 9: 614-625. PMID 18691009 DOI: 10.2174/138945008785132411  0.749
2008 Newton AC. Protein kinase C. Iubmb Life. 60: 765-8. PMID 18683875 DOI: 10.1002/Iub.118  0.542
2008 Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. The Embo Journal. 27: 1932-43. PMID 18566586 DOI: 10.1038/Emboj.2008.120  0.763
2008 Brognard J, Newton AC. PHLiPPing the switch on Akt and protein kinase C signaling. Trends in Endocrinology and Metabolism: Tem. 19: 223-30. PMID 18511290 DOI: 10.1016/J.Tem.2008.04.001  0.813
2008 Dries DR, Newton AC. Kinetic analysis of the interaction of the C1 domain of protein kinase C with lipid membranes by stopped-flow spectroscopy. The Journal of Biological Chemistry. 283: 7885-93. PMID 18187412 DOI: 10.1074/Jbc.M709943200  0.416
2008 Gao T, Brognard J, Newton AC. The phosphatase PHLPP controls the cellular levels of protein kinase C. The Journal of Biological Chemistry. 283: 6300-11. PMID 18162466 DOI: 10.1074/Jbc.M707319200  0.851
2007 Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. The Journal of Biological Chemistry. 282: 33776-87. PMID 17893151 DOI: 10.1074/Jbc.M703320200  0.836
2007 Brognard J, Sierecki E, Gao T, Newton AC. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Molecular Cell. 25: 917-31. PMID 17386267 DOI: 10.1016/J.Molcel.2007.02.017  0.836
2007 Kunkel MT, Toker A, Tsien RY, Newton AC. Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. The Journal of Biological Chemistry. 282: 6733-42. PMID 17189263 DOI: 10.1074/Jbc.M608086200  0.475
2007 Dries DR, Gallegos LL, Newton AC. A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production. The Journal of Biological Chemistry. 282: 826-30. PMID 17071619 DOI: 10.1074/Jbc.C600268200  0.816
2007 Brognard J, Sierecki E, Gao T, Newton AC. Akt Signaling is Differentially Terminated by the Phosphatase PHLPP and a New Isoform, PHLPP2 The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A619  0.77
2006 Gao T, Newton AC. Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70 Journal of Biological Chemistry. 281: 32461-32468. PMID 16954220 DOI: 10.1074/Jbc.M604076200  0.733
2006 Gallegos LL, Kunkel MT, Newton AC. Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling. The Journal of Biological Chemistry. 281: 30947-56. PMID 16901905 DOI: 10.1074/Jbc.M603741200  0.854
2006 Giorgione JR, Lin JH, McCammon JA, Newton AC. Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment. The Journal of Biological Chemistry. 281: 1660-9. PMID 16293612 DOI: 10.1074/Jbc.M510251200  0.456
2005 Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Molecular Cell. 18: 13-24. PMID 15808505 DOI: 10.1016/J.Molcel.2005.03.008  0.732
2005 Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. The Journal of Biological Chemistry. 280: 5581-7. PMID 15583002 DOI: 10.1074/Jbc.M411534200  0.546
2004 King CC, Newton AC. The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1 Journal of Biological Chemistry. 279: 37518-37527. PMID 15210700 DOI: 10.1074/Jbc.M405340200  0.565
2004 Newton AC. Diacylglycerol's affair with protein kinase C turns 25. Trends in Pharmacological Sciences. 25: 175-7. PMID 15116719 DOI: 10.1016/J.Tips.2004.02.010  0.597
2004 Chen D, Purohit A, Halilovic E, Doxsey SJ, Newton AC. Centrosomal anchoring of protein kinase C betaII by pericentrin controls microtubule organization, spindle function, and cytokinesis. The Journal of Biological Chemistry. 279: 4829-39. PMID 14594954 DOI: 10.1074/Jbc.M311196200  0.632
2003 Violin JD, Newton AC. Pathway illuminated: visualizing protein kinase C signaling. Iubmb Life. 55: 653-60. PMID 14769001 DOI: 10.1080/152165401310001642216  0.81
2003 Giorgione J, Hysell M, Harvey DF, Newton AC. Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C. Biochemistry. 42: 11194-202. PMID 14503869 DOI: 10.1021/Bi0350046  0.516
2003 Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T. A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 100: 9470-5. PMID 12881490 DOI: 10.1073/Pnas.1633695100  0.621
2003 Nalefski EA, Newton AC. Use of stopped-flow fluorescence spectroscopy to measure rapid membrane binding by protein kinase C. Methods in Molecular Biology (Clifton, N.J.). 233: 115-28. PMID 12840503 DOI: 10.1385/1-59259-397-6:115  0.799
2003 Giorgione J, Newton AC. Measuring the binding of protein kinase C to sucrose-loaded vesicles. Methods in Molecular Biology (Clifton, N.J.). 233: 105-13. PMID 12840502 DOI: 10.1385/1-59259-397-6:105  0.499
2003 Newton AC. Measuring the interaction of protein kinase C with membranes: an introduction. Methods in Molecular Biology (Clifton, N.J.). 233: 89-92. PMID 12840500 DOI: 10.1385/1-59259-397-6:89  0.521
2003 Newton AC. The ins and outs of protein kinase C. Methods in Molecular Biology (Clifton, N.J.). 233: 3-7. PMID 12840493 DOI: 10.1385/1-59259-397-6:3  0.583
2003 Bertolini TM, Giorgione J, Harvey DF, Newton AC. Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions. The Journal of Organic Chemistry. 68: 5028-36. PMID 12816455 DOI: 10.1021/Jo030029W  0.476
2003 Adams RA, Liu X, Williams DS, Newton AC. Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light. The Biochemical Journal. 374: 537-43. PMID 12809555 DOI: 10.1042/Bj20030408  0.766
2003 Violin JD, Zhang J, Tsien RY, Newton AC. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. The Journal of Cell Biology. 161: 899-909. PMID 12782683 DOI: 10.1083/Jcb.200302125  0.799
2003 Newton AC. Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. The Biochemical Journal. 370: 361-71. PMID 12495431 DOI: 10.1042/Bj20021626  0.627
2002 Gao T, Newton AC. The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C Journal of Biological Chemistry. 277: 31585-31592. PMID 12080070 DOI: 10.1074/Jbc.M204335200  0.765
2002 Zacharias DA, Violin JD, Newton AC, Tsien RY. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science (New York, N.Y.). 296: 913-6. PMID 11988576 DOI: 10.1126/Science.1068539  0.683
2002 Cenni V, Döppler H, Sonnenburg ED, Maraldi N, Newton AC, Toker A. Regulation of novel protein kinase C epsilon by phosphorylation. The Biochemical Journal. 363: 537-45. PMID 11964154 DOI: 10.1042/0264-6021:3630537  0.844
2002 Newton AC. Analyzing protein kinase C activation. Methods in Enzymology. 345: 499-506. PMID 11665632 DOI: 10.1016/S0076-6879(02)45041-0  0.646
2001 Newton AC. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chemical Reviews. 101: 2353-64. PMID 11749377 DOI: 10.1021/Cr0002801  0.565
2001 Perkins GA, Wang L, Huang LJ, Humphries K, Yao VJ, Martone M, Deerinck TJ, Barraclough DM, Violin JD, Smith D, Newton A, Scott JD, Taylor SS, Ellisman MH. PKA, PKC, and AKAP localization in and around the neuromuscular junction. Bmc Neuroscience. 2: 17. PMID 11716788 DOI: 10.1186/1471-2202-2-17  0.738
2001 Nalefski EA, Newton AC. Membrane binding kinetics of protein kinase C betaII mediated by the C2 domain. Biochemistry. 40: 13216-29. PMID 11683630 DOI: 10.1021/Bi010761U  0.775
2001 Sonnenburg ED, Gao T, Newton AC. The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase. The Journal of Biological Chemistry. 276: 45289-97. PMID 11579098 DOI: 10.1074/Jbc.M107416200  0.875
2001 Gao T, Toker A, Newton AC. The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1. The Journal of Biological Chemistry. 276: 19588-96. PMID 11376011 DOI: 10.1074/Jbc.M101357200  0.791
2000 Toker A, Newton AC. Cellular signaling: pivoting around PDK-1. Cell. 103: 185-8. PMID 11057891 DOI: 10.1016/S0092-8674(00)00110-0  0.305
2000 King CC, Gardiner EMM, Zenke FT, Bohl BP, Newton AC, Hemmings BA, Bokoch GM. p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1) Journal of Biological Chemistry. 275: 41201-41209. PMID 10995762 DOI: 10.1074/Jbc.M006553200  0.591
2000 Johnson JE, Giorgione J, Newton AC. The C1 and C2 domains of protein kinase C are independent membrane targeting modules, with specificity for phosphatidylserine conferred by the C1 domain. Biochemistry. 39: 11360-9. PMID 10985781 DOI: 10.1021/Bi000902C  0.472
2000 Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. Protein kinase C isozymes and the regulation of diverse cell responses. American Journal of Physiology. Lung Cellular and Molecular Physiology. 279: L429-38. PMID 10956616 DOI: 10.1152/Ajplung.2000.279.3.L429  0.624
2000 Granados-Soto V, Kalcheva I, Hua X, Newton A, Yaksh TL. Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion. Pain. 85: 395-404. PMID 10781912 DOI: 10.1016/S0304-3959(99)00281-X  0.352
2000 King CC, Zenke FT, Dawson PE, Dutil EM, Newton AC, Hemmings BA, Bokoch GM. Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1 Journal of Biological Chemistry. 275: 18108-18113. PMID 10748151 DOI: 10.1074/Jbc.M909663199  0.595
2000 Dutil EM, Newton AC. Dual role of pseudosubstrate in the coordinated regulation of protein kinase C by phosphorylation and diacylglycerol. The Journal of Biological Chemistry. 275: 10697-701. PMID 10744767 DOI: 10.1074/Jbc.275.14.10697  0.619
2000 Toker A, Newton AC. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. The Journal of Biological Chemistry. 275: 8271-4. PMID 10722653 DOI: 10.1074/Jbc.275.12.8271  0.559
1999 Faux MC, Rollins EN, Edwards AS, Langeberg LK, Newton AC, Scott JD. Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction. The Biochemical Journal. 343: 443-52. PMID 10510312 DOI: 10.1042/0264-6021:3430443  0.853
1999 Behn-Krappa A, Newton AC. The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation. Current Biology : Cb. 9: 728-37. PMID 10421574 DOI: 10.1016/S0960-9822(99)80332-7  0.539
1999 Edwards AS, Faux MC, Scott JD, Newton AC. Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII. The Journal of Biological Chemistry. 274: 6461-8. PMID 10037738 DOI: 10.1074/Jbc.274.10.6461  0.858
1998 Dutil EM, Toker A, Newton AC. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Current Biology : Cb. 8: 1366-75. PMID 9889098 DOI: 10.1016/S0960-9822(98)00017-7  0.628
1998 Mosior M, Newton AC. Mechanism of the apparent cooperativity in the interaction of protein kinase C with phosphatidylserine. Biochemistry. 37: 17271-9. PMID 9860841 DOI: 10.1021/Bi981344T  0.549
1998 Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS, Newton AC, Schaffhausen BS, Toker A. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Current Biology : Cb. 8: 1069-77. PMID 9768361 DOI: 10.1016/S0960-9822(98)70444-0  0.633
1998 Newton AC, Johnson JE. Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules. Biochimica Et Biophysica Acta. 1376: 155-72. PMID 9748550 DOI: 10.1016/S0304-4157(98)00003-3  0.539
1998 Johnson JE, Zimmerman ML, Daleke DL, Newton AC. Lipid structure and not membrane structure is the major determinant in the regulation of protein kinase C by phosphatidylserine. Biochemistry. 37: 12020-5. PMID 9724512 DOI: 10.1021/Bi981107Q  0.803
1998 Sweatt JD, Atkins CM, Johnson J, English JD, Roberson ED, Chen SJ, Newton A, Klann E. Protected-site phosphorylation of protein kinase C in hippocampal long-term potentiation. Journal of Neurochemistry. 71: 1075-85. PMID 9721732 DOI: 10.1046/J.1471-4159.1998.71031075.X  0.528
1998 Udovichenko IP, Newton AC, Williams DS. Regulation of the phosphorylation state of rhodopsin by dopamine Journal of Biological Chemistry. 273: 7181-7184. PMID 9516406 DOI: 10.1074/Jbc.273.13.7181  0.376
1997 Edwards AS, Newton AC. Regulation of protein kinase C betaII by its C2 domain. Biochemistry. 36: 15615-23. PMID 9398289 DOI: 10.1021/Bi9718752  0.811
1997 Johnson JE, Edwards AS, Newton AC. A putative phosphatidylserine binding motif is not involved in the lipid regulation of protein kinase C. The Journal of Biological Chemistry. 272: 30787-92. PMID 9388219 DOI: 10.1074/Jbc.272.49.30787  0.849
1997 Williams DS, Liu X, Schlamp CL, Ondek B, Jaken S, Newton AC. Characterization of protein kinase C in photoreceptor outer segments. Journal of Neurochemistry. 69: 1693-702. PMID 9326298 DOI: 10.1046/J.1471-4159.1997.69041693.X  0.473
1997 Keranen LM, Newton AC. Ca2+ differentially regulates conventional protein kinase Cs' membrane interaction and activation. The Journal of Biological Chemistry. 272: 25959-67. PMID 9325330 DOI: 10.1074/Jbc.272.41.25959  0.829
1997 Edwards AS, Newton AC. Phosphorylation at conserved carboxyl-terminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C. The Journal of Biological Chemistry. 272: 18382-90. PMID 9218480 DOI: 10.1074/Jbc.272.29.18382  0.853
1997 Greene NM, Williams DS, Newton AC. Identification of protein kinase C phosphorylation sites on bovine rhodopsin Journal of Biological Chemistry. 272: 10341-10344. PMID 9099669 DOI: 10.1074/Jbc.272.16.10341  0.575
1997 Newton AC. Regulation of protein kinase C. Current Opinion in Cell Biology. 9: 161-7. PMID 9069266 DOI: 10.1016/S0955-0674(97)80058-0  0.599
1997 Udovichenko IP, Newton AC, Williams DS. Contribution of protein kinase C to the phosphorylation of rhodopsin in intact retinas Journal of Biological Chemistry. 272: 7952-7959. PMID 9065465 DOI: 10.1074/Jbc.272.12.7952  0.626
1997 Hurley JH, Newton AC, Parker PJ, Blumberg PM, Nishizuka Y. Taxonomy and function of C1 protein kinase C homology domains. Protein Science : a Publication of the Protein Society. 6: 477-80. PMID 9041654 DOI: 10.1002/Pro.5560060228  0.436
1996 Arnold RS, Newton AC. Inhibition of the insulin receptor tyrosine kinase by phosphatidic acid. Journal of Cellular Biochemistry. 62: 516-28. PMID 8891897 DOI: 10.1002/(Sici)1097-4644(19960915)62:4<516::Aid-Jcb9>3.0.Co;2-P  0.659
1996 Newton AC. Protein kinase C: Ports of anchor in the cell Current Biology. 6: 806-809. PMID 8805297 DOI: 10.1016/S0960-9822(02)00600-0  0.549
1996 Mosior M, Newton AC. Calcium-independent binding to interfacial phorbol esters causes protein kinase C to associate with membranes in the absence of acidic lipids. Biochemistry. 35: 1612-1623. PMID 8634293 DOI: 10.1021/Bi952031Q  0.559
1996 Arnold RS, Newton AC. Diacylglycerol directly stimulates the insulin receptor tyrosine kinase. Febs Letters. 380: 58-62. PMID 8603747 DOI: 10.1016/0014-5793(96)00006-3  0.681
1995 Keranen LM, Dutil EM, Newton AC. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Current Biology : Cb. 5: 1394-1403. PMID 8749392 DOI: 10.1016/S0960-9822(95)00277-6  0.873
1995 Newton AC. Protein Kinase C: Seeing two domains Current Biology. 5: 973-976. PMID 8542286 DOI: 10.1016/S0960-9822(95)00191-6  0.528
1995 Greener NM, Williams DS, Newton AC. Kinetics and localization of the phosphorylation of rhodopsin by protein kinase C Journal of Biological Chemistry. 270: 6710-6717. PMID 7896814 DOI: 10.1074/Jbc.270.12.6710  0.626
1995 Mosior M, Newton AC. Mechanism of Interaction of Protein Kinase C with Phorbol Esters REVERSIBILITY AND NATURE OF MEMBRANE ASSOCIATION Journal of Biological Chemistry. 270: 25526-25533. PMID 7592722 DOI: 10.1074/Jbc.270.43.25526  0.525
1995 Newton AC. Protein Kinase C: Structure, Function, and Regulation Journal of Biological Chemistry. 270: 28495-28498. PMID 7499357 DOI: 10.1074/Jbc.270.48.28495  0.593
1995 Hecht GB, Lane T, Ohta N, Sommer JM, Newton A. An essential single domain response regulator required for normal cell division and differentiation in Caulobacter crescentus. The Embo Journal. 14: 3915-3924. DOI: 10.1002/J.1460-2075.1995.Tb00063.X  0.502
1994 Newton AC, Keranen LM. Phosphatidyl-L-serine is necessary for protein kinase C's high-affinity interaction with diacylglycerol-containing membranes. Biochemistry. 33: 6651-8. PMID 8204602 DOI: 10.1021/Bi00187A035  0.852
1994 Daleke DL, Huestis WH, Newton AC. Protein kinase C as a measure of transbilayer phosphatidylserine asymmetry Analytical Biochemistry. 217: 33-40. PMID 8203737 DOI: 10.1006/Abio.1994.1080  0.86
1994 Orr JW, Newton AC. Intrapeptide regulation of protein kinase C. The Journal of Biological Chemistry. 269: 8383-7. PMID 8132562  0.759
1994 Dutil EM, Keranen LM, DePaoli-Roach AA, Newton AC. In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation Journal of Biological Chemistry. 269: 29359-29362. PMID 7961910  0.862
1994 Orr JW, Newton AC. Requirement for negative charge on "activation loop" of protein kinase C. The Journal of Biological Chemistry. 269: 27715-8. PMID 7961692  0.771
1994 Williams DS, Park S, Schlamp CL, Newton AC. Protein kinase C association with the retinal cytoskeleton and phosphorylation of vimentin Experimental Eye Research. 58: 747-759. PMID 7925714 DOI: 10.1006/Exer.1994.1072  0.596
1994 Kornacker MG, Newton A. Information essential for cell-cycle-dependent secretion of the 591-residue Caulobacter hook protein is confined to a 21-amino-acid sequence near the N-terminus. Molecular Microbiology. 14: 73-85. PMID 7830563 DOI: 10.1111/J.1365-2958.1994.Tb01268.X  0.4
1994 Conrad R, Keranen LM, Ellington AD, Newton AC. Isozyme-specific inhibition of protein kinase C by RNA aptamers. The Journal of Biological Chemistry. 269: 32051-4. PMID 7528207  0.835
1993 Newton AC, Williams DS. Rhodopsin is the major in situ substrate of protein kinase C in rod outer segments of photoreceptors Journal of Biological Chemistry. 268: 18181-18186. PMID 8349693  0.496
1993 Newton AC. Interaction of proteins with lipid headgroups: lessons from protein kinase C. Annual Review of Biophysics and Biomolecular Structure. 22: 1-25. PMID 8347986 DOI: 10.1146/Annurev.Bb.22.060193.000245  0.537
1993 Newton AC, Williams DS. Does protein kinase C play a role in rhodopsin desensitization? Trends in Biochemical Sciences. 18: 275-277. PMID 8236436 DOI: 10.1016/0968-0004(93)90032-I  0.56
1992 Orr JW, Keranen LM, Newton AC. Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol. The Journal of Biological Chemistry. 267: 15263-6. PMID 1639770  0.867
1992 Orr JW, Newton AC. Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation. Biochemistry. 31: 4667-73. PMID 1581317 DOI: 10.1021/Bi00134A019  0.744
1992 Orr JW, Newton AC. Interaction of protein kinase C with phosphatidylserine. 1. Cooperativity in lipid binding. Biochemistry. 31: 4661-7. PMID 1581316 DOI: 10.1021/Bi00134A018  0.777
1991 Newton AC, Williams DS. Involvement of protein kinase C in the phosphorylation of rhodopsin Journal of Biological Chemistry. 266: 17725-17728. PMID 1917916  0.517
1991 Arnold RS, Newton AC. Inhibition of the insulin receptor tyrosine kinase by sphingosine. Biochemistry. 30: 7747-54. PMID 1651108 DOI: 10.1021/Bi00245A011  0.724
1990 Newton AC, Koshland DE. Phosphatidylserine affects specificity of protein kinase C substrate phosphorylation and autophosphorylation. Biochemistry. 29: 6656-61. PMID 2397206 DOI: 10.1021/Bi00480A015  0.689
1989 Newton AC, Koshland DE. High cooperativity, specificity, and multiplicity in the protein kinase C-lipid interaction. The Journal of Biological Chemistry. 264: 14909-15. PMID 2768246  0.655
1988 Newton AC, Huestis WH. Vesicle-to-cell protein transfer: Insertion of band 3, the erythrocyte anion transporter, into lymphoid cells Biochemistry. 27: 4655-4659. PMID 3167008 DOI: 10.1021/Bi00413A011  0.66
1988 Newton AC, Huestis WH. Lymphonia-vesicle interactions: Vesicle adsorption, membrane fragmentation, and intermembrane protein transfer Biochemistry. 27: 4645-4655. PMID 3167007 DOI: 10.1021/Bi00413A010  0.651
1988 Newton AC, Huestis WH. Lymphoma-vesicle interactions: vesicle adsorption, membrane fragmentation, and intermembrane protein transfer [Erratum to document cited in CA109(3):19823m] Biochemistry. 27: 9226-9226. DOI: 10.1021/Bi00426A025  0.641
1987 Newton AC, Koshland DE. Protein kinase C autophosphorylates by an intrapeptide reaction. The Journal of Biological Chemistry. 262: 10185-8. PMID 3611058  0.663
1987 Baudier J, Mochly-Rosen D, Newton A, Lee SH, Koshland DE, Cole RD. Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C. Biochemistry. 26: 2886-93. PMID 3111527 DOI: 10.1021/Bi00384A033  0.531
1986 Huestis WH, Newton AC. Intermembrane protein transfer. Band 3, the erythrocyte anion transporter, transfers in native orientation from human red blood cells into the bilayer of phospholipid vesicles Journal of Biological Chemistry. 261: 16274-16278. PMID 3782118  0.605
1986 Newton AC, Huestis WH. Efflux of dipicolinic acid from human erythrocytes, sealed membrane fragments, and band 3-liposome complexes: A fluorescence probe for the erythrocyte anion transporter Analytical Biochemistry. 156: 56-60. PMID 3740418 DOI: 10.1016/0003-2697(86)90153-3  0.609
1983 Newton AC, Cook SL, Huestis WH, Ferrell JE. Transfer of band 3, the erythrocyte anion transporter, between phospholipid vesicles and cells Biochemistry. 22: 6110-6117. PMID 6661430 DOI: 10.1021/Bi00295A011  0.733
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