| Year |
Citation |
Score |
| 2023 |
Gheorghita AA, Wozniak DJ, Parsek MR, Howell PL. Pseudomonas aeruginosa biofilm exopolysaccharides: Assembly, function, and degradation. Fems Microbiology Reviews. PMID 37884397 DOI: 10.1093/femsre/fuad060 |
0.319 |
|
| 2023 |
Low KE, Gheorghita AA, Tammam SD, Whitfield GB, Li YE, Riley LM, Weadge JT, Caldwell SJ, Chong PA, Walvoort MTC, Kitova EN, Klassen JS, Codée JDC, Howell PL. Pseudomonas aeruginosa AlgF is a protein-protein interaction mediator required for acetylation of the alginate exopolysaccharide. The Journal of Biological Chemistry. 105314. PMID 37797696 DOI: 10.1016/j.jbc.2023.105314 |
0.795 |
|
| 2022 |
Pfoh R, Subramanian AS, Huang J, Little DJ, Forman A, DiFrancesco BR, Balouchestani-Asli N, Kitova EN, Klassen JS, Pomès R, Nitz M, Howell PL. The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing. Plos Pathogens. 18: e1010750. PMID 35930610 DOI: 10.1371/journal.ppat.1010750 |
0.363 |
|
| 2022 |
Gheorghita AA, Wolfram F, Whitfield GB, Jacobs HM, Pfoh R, Wong SSY, Guitor AK, Goodyear MC, Berezuk AM, Khursigara CM, Parsek MR, Howell PL. The Pseudomonas aeruginosa homeostasis enzyme AlgL clears the periplasmic space of accumulated alginate during polymer biosynthesis. The Journal of Biological Chemistry. 101560. PMID 34990713 DOI: 10.1016/j.jbc.2021.101560 |
0.314 |
|
| 2020 |
McCallum M, Tammam S, Rubinstein JL, Burrows LL, Howell PL. CryoEM map of Pseudomonas aeruginosa PilQ enables structural characterization of TsaP. Structure (London, England : 1993). PMID 33338410 DOI: 10.1016/j.str.2020.11.019 |
0.783 |
|
| 2020 |
Marmont LS, Whitfield GB, Pfoh R, Williams RJ, Randall TE, Ostaszewski A, Razvi E, Groves RA, Robinson H, Nitz M, Parsek MR, Lewis IA, Whitney JC, Harrison J, Howell PL. PelX is a UDP-N-acetylglucosamine C4-epimerase involved in Pel polysaccharide-dependent biofilm formation. The Journal of Biological Chemistry. PMID 32601062 DOI: 10.1074/Jbc.Ra120.014555 |
0.396 |
|
| 2020 |
Fustin JM, Ye S, Rakers C, Kaneko K, Fukumoto K, Yamano M, Versteven M, Grünewald E, Cargill SJ, Tamai TK, Xu Y, Jabbur ML, Kojima R, Lamberti ML, Yoshioka-Kobayashi K, ... ... Howell PL, et al. Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans. Communications Biology. 3: 295. PMID 32499511 DOI: 10.1038/s42003-020-1031-0 |
0.723 |
|
| 2020 |
Bamford NC, Le Mauff F, Van Loon JC, Ostapska H, Snarr BD, Zhang Y, Kitova EN, Klassen JS, Codée JDC, Sheppard DC, Howell PL. Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation. Nature Communications. 11: 2450. PMID 32415073 DOI: 10.1038/S41467-020-16144-5 |
0.403 |
|
| 2020 |
Fustin JM, Ye S, Rakers C, Kaneko K, Fukumoto K, Yamano M, Versteven M, Grünewald E, Cargill SJ, Tamai TK, Xu Y, Jabbur ML, Kojima R, Lamberti ML, Yoshioka-Kobayashi K, ... ... Howell PL, et al. Methylation deficiency disrupts biological rhythms from bacteria to humans. Communications Biology. 3: 211. PMID 32376902 DOI: 10.1038/s42003-020-0942-0 |
0.723 |
|
| 2020 |
Jones CS, Sychantha D, Howell PL, Clarke AJ. Structural basis for the -acetyltransferase function of the extracytoplasmic domain of OatA from . The Journal of Biological Chemistry. PMID 32350117 DOI: 10.1074/Jbc.Ra120.013108 |
0.462 |
|
| 2020 |
Whitfield GB, Marmont LS, Bundalovic-Torma C, Razvi E, Roach EJ, Khursigara CM, Parkinson J, Howell PL. Discovery and characterization of a Gram-positive Pel polysaccharide biosynthetic gene cluster. Plos Pathogens. 16: e1008281. PMID 32236137 DOI: 10.1371/Journal.Ppat.1008281 |
0.365 |
|
| 2020 |
Bundalovic-Torma C, Whitfield GB, Marmont LS, Howell PL, Parkinson J. A systematic pipeline for classifying bacterial operons reveals the evolutionary landscape of biofilm machineries. Plos Computational Biology. 16: e1007721. PMID 32236097 DOI: 10.1371/Journal.Pcbi.1007721 |
0.386 |
|
| 2020 |
Whitfield GB, Marmont LS, Ostaszewski A, Rich JD, Whitney JC, Parsek MR, Harrison JJ, Howell PL. Pel polysaccharide biosynthesis requires an inner membrane complex comprised of PelD, PelE, PelF and PelG. Journal of Bacteriology. PMID 31988082 DOI: 10.1128/Jb.00684-19 |
0.455 |
|
| 2019 |
McCallum M, Benlekbir S, Nguyen S, Tammam S, Rubinstein JL, Burrows LL, Howell PL. Multiple conformations facilitate PilT function in the type IV pilus. Nature Communications. 10: 5198. PMID 31729381 DOI: 10.2210/Pdb6Olj/Pdb |
0.768 |
|
| 2019 |
Forman A, Pfoh R, Eddenden A, Howell PL, Nitz M. Synthesis of defined mono-de-N-acetylated β-(1→6)-N-acetyl-d-glucosamine oligosaccharides to characterize PgaB hydrolase activity. Organic & Biomolecular Chemistry. PMID 31642455 DOI: 10.1039/C9Ob02079A |
0.386 |
|
| 2019 |
Bamford NC, Le Mauff F, Subramanian AS, Yip P, Millán C, Zhang Y, Zacharias C, Forman A, Nitz M, Codée JDC, Usón I, Sheppard DC, Howell PL. Ega3 from the fungal pathogen is an endo-α-1,4-galactosaminidase that disrupts microbialbiofilms. The Journal of Biological Chemistry. PMID 31416836 DOI: 10.1074/Jbc.Ra119.009910 |
0.383 |
|
| 2019 |
Le Mauff F, Bamford NC, Alnabelseya N, Zhang Y, Baker P, Robinson H, Codée JDC, Howell PL, Sheppard DC. Molecular mechanism of biofilm disruption by fungal and bacterial glycoside hydrolases. The Journal of Biological Chemistry. PMID 31167793 DOI: 10.1074/Jbc.Ra119.008511 |
0.482 |
|
| 2019 |
McCallum M, Burrows LL, Howell PL. The Dynamic Structures of the Type IV Pilus. Microbiology Spectrum. 7: 113-128. DOI: 10.1128/Microbiolspec.Psib-0006-2018 |
0.374 |
|
| 2018 |
Low KE, Howell PL. Gram-negative synthase-dependent exopolysaccharide biosynthetic machines. Current Opinion in Structural Biology. 53: 32-44. PMID 29843050 DOI: 10.1016/J.Sbi.2018.05.001 |
0.373 |
|
| 2018 |
Little DJ, Pfoh R, Le Mauff F, Bamford NC, Notte C, Baker P, Guragain M, Robinson H, Pier GB, Nitz M, Deora R, Sheppard DC, Howell PL. PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms. Plos Pathogens. 14: e1006998. PMID 29684093 DOI: 10.1371/Journal.Ppat.1006998 |
0.452 |
|
| 2018 |
Asker D, Awad TS, Baker P, Howell PL, Hatton BD. Non-eluting, surface-bound enzymes disrupt surface attachment of bacteria by continuous biofilm polysaccharide degradation. Biomaterials. 167: 168-176. PMID 29571052 DOI: 10.1016/J.Biomaterials.2018.03.016 |
0.322 |
|
| 2018 |
Sychantha D, Chapman R, Bamford NC, Boons GJ, Howell PL, Clarke AJ. Molecular basis for the attachment of S-layer proteins to the cell wall of Bacillus anthracis. Biochemistry. PMID 29522326 DOI: 10.1021/Acs.Biochem.8B00060 |
0.428 |
|
| 2018 |
Leighton TL, Mok MC, Junop MS, Howell PL, Burrows LL. Conserved, unstructured regions in Pseudomonas aeruginosa PilO are important for type IVa pilus function. Scientific Reports. 8: 2600. PMID 29422606 DOI: 10.1038/s41598-018-20925-w |
0.378 |
|
| 2017 |
Sychantha D, Little DJ, Chapman RN, Boons GJ, Robinson H, Howell PL, Clarke AJ. PatB1 is an O-acetyltransferase that decorates secondary cell wall polysaccharides. Nature Chemical Biology. PMID 29083419 DOI: 10.1038/Nchembio.2509 |
0.351 |
|
| 2017 |
Sychantha D, Jones CS, Little DJ, Moynihan PJ, Robinson H, Galley NF, Roper DI, Dowson CG, Howell PL, Clarke AJ. In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA). Plos Pathogens. 13: e1006667. PMID 29077761 DOI: 10.1371/Journal.Ppat.1006667 |
0.468 |
|
| 2017 |
Marmont LS, Whitfield GB, Rich JD, Yip P, Giesbrecht LB, Stremick CA, Whitney JC, Parsek MR, Harrison JJ, Howell PL. PelA and PelB form a modification and secretion complex essential for Pel polysaccharide-dependent biofilm formation in Pseudomonas aeruginosa. The Journal of Biological Chemistry. PMID 28972168 DOI: 10.1074/Jbc.M117.812842 |
0.488 |
|
| 2017 |
Snarr BD, Baker P, Bamford NC, Sato Y, Liu H, Lehoux M, Gravelat FN, Ostapska H, Baistrocchi SR, Cerone RP, Filler EE, Parsek MR, Filler SG, Howell PL, Sheppard DC. Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 28634301 DOI: 10.1073/Pnas.1702798114 |
0.393 |
|
| 2017 |
Buensuceso RNC, Daniel-Ivad M, Kilmury SLN, Leighton TL, Harvey H, Howell PL, Burrows LL. cAMP-independent control of twitching motility in Pseudomonas aeruginosa. Journal of Bacteriology. PMID 28583947 DOI: 10.1128/Jb.00188-17 |
0.427 |
|
| 2017 |
McCallum M, Tammam S, Khan A, Burrows LL, Howell PL. The molecular mechanism of the type IVa pilus motors. Nature Communications. 8: 15091. PMID 28474682 DOI: 10.1038/Ncomms15091 |
0.792 |
|
| 2017 |
Limoli DH, Whitfield GB, Kitao T, Ivey ML, Davis MR, Grahl N, Hogan DA, Rahme LG, Howell PL, O'Toole GA, Goldberg JB. Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection. Mbio. 8. PMID 28325763 DOI: 10.1128/Mbio.00186-17 |
0.326 |
|
| 2017 |
Marmont LS, Rich JD, Whitney JC, Whitfield GB, Almblad H, Robinson H, Parsek MR, Harrison JJ, Howell PL. Oligomeric lipoprotein PelC guides Pel polysaccharide export across the outer membrane of Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America. PMID 28242707 DOI: 10.1073/Pnas.1613606114 |
0.474 |
|
| 2017 |
Carter T, Buensuceso RN, Tammam S, Lamers RP, Harvey H, Howell PL, Burrows LL. The Type IVa Pilus Machinery Is Recruited to Sites of Future Cell Division. Mbio. 8. PMID 28143978 DOI: 10.1128/Mbio.02103-16 |
0.8 |
|
| 2016 |
Koo J, Lamers RP, Rubinstein JL, Burrows LL, Howell PL. Structure of the Pseudomonas aeruginosa Type IVa Pilus Secretin at 7.4 Å. Structure (London, England : 1993). 24: 1778-1787. PMID 27705815 DOI: 10.1016/J.Str.2016.08.007 |
0.449 |
|
| 2016 |
Leighton TL, Yong DH, Howell PL, Burrows LL. Type IV Pilus Alignment Subcomplex Components PilN and PilO Form Homo- and Heterodimers In Vivo. The Journal of Biological Chemistry. PMID 27474743 DOI: 10.1074/Jbc.M116.738377 |
0.421 |
|
| 2016 |
Baker P, Hill PJ, Snarr BD, Alnabelseya N, Pestrak MJ, Lee MJ, Jennings LK, Tam J, Melnyk RA, Parsek MR, Sheppard DC, Wozniak DJ, Howell PL. Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms. Science Advances. 2: e1501632. PMID 27386527 DOI: 10.1126/Sciadv.1501632 |
0.326 |
|
| 2016 |
Buensuceso RN, Nguyen Y, Zhang K, Daniel-Ivad M, Sugiman-Marangos SN, Fleetwood AD, Zhulin IB, Junop MS, Howell PL, Burrows LL. The conserved TPR-containing C-terminal domain of Pseudomonas aeruginosa FimV is required for its cAMP-dependent and independent functions. Journal of Bacteriology. PMID 27297880 DOI: 10.1128/Jb.00322-16 |
0.456 |
|
| 2016 |
Sheppard DC, Howell PL. Biofilm Exopolysaccharides of Pathogenic Fungi: Lessons from Bacteria. The Journal of Biological Chemistry. PMID 27129222 DOI: 10.1074/Jbc.R116.720995 |
0.333 |
|
| 2016 |
Lee MJ, Geller AM, Bamford NC, Liu H, Gravelat FN, Snarr BD, Le Mauff F, Chabot J, Ralph B, Ostapska H, Lehoux M, Cerone RP, Baptista SD, Vinogradov E, Stajich JE, ... ... Howell PL, et al. Deacetylation of Fungal Exopolysaccharide Mediates Adhesion and Biofilm Formation. Mbio. 7. PMID 27048799 DOI: 10.1128/Mbio.00252-16 |
0.393 |
|
| 2016 |
McCallum M, Tammam S, Little DJ, Robinson H, Koo J, Shah M, Calmettes C, Moraes TF, Burrows LL, Howell PL. PilN binding modulates the structure and binding partners of the Pseudomonas aeruginosa Type IVa Pilus protein PilM. The Journal of Biological Chemistry. PMID 27022027 DOI: 10.1074/Jbc.M116.718353 |
0.801 |
|
| 2015 |
Hmelo LR, Borlee BR, Almblad H, Love ME, Randall TE, Tseng BS, Lin C, Irie Y, Storek KM, Yang JJ, Siehnel RJ, Howell PL, Singh PK, Tolker-Nielsen T, Parsek MR, et al. Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange. Nature Protocols. 10: 1820-1841. PMID 26492139 DOI: 10.1038/Nprot.2015.115 |
0.309 |
|
| 2015 |
Baker P, Whitfield GB, Hill PJ, Little DJ, Pestrak MJ, Robinson H, Wozniak DJ, Howell PL. Characterization of the Pseudomonas aeruginosa Glycoside Hydrolase PslG Reveals that its Levels are Critical for Psl Polysaccharide Biosynthesis and Biofilm Formation. The Journal of Biological Chemistry. PMID 26424791 DOI: 10.1074/Jbc.M115.674929 |
0.479 |
|
| 2015 |
Bamford NC, Snarr BD, Gravelat FN, Little DJ, Lee MJ, Zacharias CA, Chabot JC, Geller AM, Baptista SD, Baker P, Robinson H, Howell PL, Sheppard DC. Sph3 is a glycoside hydrolase required for the biosynthesis of galactosaminogalactan in Aspergillus fumigatus. The Journal of Biological Chemistry. PMID 26342082 DOI: 10.1074/Jbc.M115.679050 |
0.416 |
|
| 2015 |
Jennings LK, Storek KM, Ledvina HE, Coulon C, Marmont LS, Sadovskaya I, Secor PR, Tseng BS, Scian M, Filloux A, Wozniak DJ, Howell PL, Parsek MR. Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix. Proceedings of the National Academy of Sciences of the United States of America. 112: 11353-8. PMID 26311845 DOI: 10.1073/Pnas.1503058112 |
0.365 |
|
| 2015 |
Little DJ, Milek S, Bamford NC, Ganguly T, DiFrancesco BR, Nitz M, Deora R, Howell PL. BpsB is a Poly-β-1,6-N-acetyl-D-glucosamine Deacetylase Required for Biofilm Formation in Bordetella bronchiseptica. The Journal of Biological Chemistry. PMID 26203190 DOI: 10.1074/Jbc.M115.672469 |
0.438 |
|
| 2015 |
Roux D, Cywes-Bentley C, Zhang YF, Pons S, Konkol M, Kearns D, Little DJ, Howell PL, Skurnik D, Pier GB. Identification of Poly-N-acetyl Glucosamine as a Major Polysaccharide Component of the Bacillus Subtilis Biofilm Matrix. The Journal of Biological Chemistry. PMID 26078454 DOI: 10.1074/Jbc.M115.648709 |
0.359 |
|
| 2015 |
Whitfield GB, Marmont LS, Howell PL. Enzymatic modifications of exopolysaccharides enhance bacterial persistence. Frontiers in Microbiology. 6: 471. PMID 26029200 DOI: 10.3389/Fmicb.2015.00471 |
0.341 |
|
| 2015 |
Leighton TL, Dayalani N, Sampaleanu LM, Howell PL, Burrows LL. Novel Role for PilNO in Type IV Pilus Retraction Revealed by Alignment Subcomplex Mutations. Journal of Bacteriology. 197: 2229-38. PMID 25917913 DOI: 10.1128/Jb.00220-15 |
0.791 |
|
| 2015 |
Ariyakumaran R, Pokrovskaya V, Little DJ, Howell PL, Nitz M. Direct Staudinger-Phosphonite Reaction Provides Methylphosphonamidates as Inhibitors of CE4 De-N-acetylases. Chembiochem : a European Journal of Chemical Biology. 16: 1350-6. PMID 25864869 DOI: 10.1002/Cbic.201500091 |
0.304 |
|
| 2015 |
Whitney JC, Whitfield GB, Marmont LS, Yip P, Neculai AM, Lobsanov YD, Robinson H, Ohman DE, Howell PL. Dimeric c-di-GMP is required for post-translational regulation of alginate production in Pseudomonas aeruginosa. The Journal of Biological Chemistry. 290: 12451-62. PMID 25817996 DOI: 10.1074/Jbc.M115.645051 |
0.428 |
|
| 2015 |
Leighton TL, Buensuceso RN, Howell PL, Burrows LL. Biogenesis of Pseudomonas aeruginosa type IV pili and regulation of their function. Environmental Microbiology. PMID 25808785 DOI: 10.1111/1462-2920.12849 |
0.367 |
|
| 2014 |
Little DJ, Bamford NC, Pokrovskaya V, Robinson H, Nitz M, Howell PL. Structural basis for the De-N-acetylation of Poly-β-1,6-N-acetyl-D-glucosamine in Gram-positive bacteria. The Journal of Biological Chemistry. 289: 35907-17. PMID 25359777 DOI: 10.1074/Jbc.M114.611400 |
0.464 |
|
| 2014 |
Baker P, Ricer T, Moynihan PJ, Kitova EN, Walvoort MT, Little DJ, Whitney JC, Dawson K, Weadge JT, Robinson H, Ohman DE, Codée JD, Klassen JS, Clarke AJ, Howell PL. P. aeruginosa SGNH hydrolase-like proteins AlgJ and AlgX have similar topology but separate and distinct roles in alginate acetylation. Plos Pathogens. 10: e1004334. PMID 25165982 DOI: 10.1371/Journal.Ppat.1004334 |
0.411 |
|
| 2014 |
Little DJ, Li G, Ing C, DiFrancesco BR, Bamford NC, Robinson H, Nitz M, Pomès R, Howell PL. Modification and periplasmic translocation of the biofilm exopolysaccharide poly-β-1,6-N-acetyl-D-glucosamine. Proceedings of the National Academy of Sciences of the United States of America. 111: 11013-8. PMID 24994902 DOI: 10.1073/Pnas.1406388111 |
0.419 |
|
| 2014 |
Wolfram F, Kitova EN, Robinson H, Walvoort MT, Codée JD, Klassen JS, Howell PL. Catalytic mechanism and mode of action of the periplasmic alginate epimerase AlgG. The Journal of Biological Chemistry. 289: 6006-19. PMID 24398681 DOI: 10.1074/Jbc.M113.533158 |
0.426 |
|
| 2013 |
Pokrovskaya V, Poloczek J, Little DJ, Griffiths H, Howell PL, Nitz M. Functional characterization of Staphylococcus epidermidis IcaB, a de-N-acetylase important for biofilm formation. Biochemistry. 52: 5463-71. PMID 23866051 DOI: 10.1021/Bi400836G |
0.359 |
|
| 2013 |
Riley LM, Weadge JT, Baker P, Robinson H, Codée JD, Tipton PA, Ohman DE, Howell PL. Structural and functional characterization of Pseudomonas aeruginosa AlgX: role of AlgX in alginate acetylation. The Journal of Biological Chemistry. 288: 22299-314. PMID 23779107 DOI: 10.1074/Jbc.M113.484931 |
0.383 |
|
| 2013 |
Koo J, Tang T, Harvey H, Tammam S, Sampaleanu L, Burrows LL, Howell PL. Functional mapping of PilF and PilQ in the Pseudomonas aeruginosa type IV pilus system. Biochemistry. 52: 2914-23. PMID 23547883 DOI: 10.1021/Bi3015345 |
0.808 |
|
| 2013 |
Colvin KM, Alnabelseya N, Baker P, Whitney JC, Howell PL, Parsek MR. PelA deacetylase activity is required for Pel polysaccharide synthesis in Pseudomonas aeruginosa. Journal of Bacteriology. 195: 2329-39. PMID 23504011 DOI: 10.1128/JB.02150-12 |
0.316 |
|
| 2013 |
Tammam S, Sampaleanu LM, Koo J, Manoharan K, Daubaras M, Burrows LL, Howell PL. PilMNOPQ from the Pseudomonas aeruginosa type IV pilus system form a transenvelope protein interaction network that interacts with PilA. Journal of Bacteriology. 195: 2126-35. PMID 23457250 DOI: 10.1128/Jb.00032-13 |
0.803 |
|
| 2013 |
Takhar HK, Kemp K, Kim M, Howell PL, Burrows LL. The platform protein is essential for type IV pilus biogenesis. The Journal of Biological Chemistry. 288: 9721-8. PMID 23413032 DOI: 10.1074/Jbc.M113.453506 |
0.501 |
|
| 2013 |
Whitney JC, Howell PL. Synthase-dependent exopolysaccharide secretion in Gram-negative bacteria. Trends in Microbiology. 21: 63-72. PMID 23117123 DOI: 10.1016/j.tim.2012.10.001 |
0.323 |
|
| 2012 |
Whitney JC, Colvin KM, Marmont LS, Robinson H, Parsek MR, Howell PL. Structure of the cytoplasmic region of PelD, a degenerate diguanylate cyclase receptor that regulates exopolysaccharide production in Pseudomonas aeruginosa. The Journal of Biological Chemistry. 287: 23582-93. PMID 22605337 DOI: 10.1074/Jbc.M112.375378 |
0.464 |
|
| 2012 |
Broom A, Doxey AC, Lobsanov YD, Berthin LG, Rose DR, Howell PL, McConkey BJ, Meiering EM. Modular evolution and the origins of symmetry: reconstruction of a three-fold symmetric globular protein. Structure (London, England : 1993). 20: 161-71. PMID 22178248 DOI: 10.1016/J.Str.2011.10.021 |
0.369 |
|
| 2012 |
Colvin KM, Irie Y, Tart CS, Urbano R, Whitney JC, Ryder C, Howell PL, Wozniak DJ, Parsek MR. The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix. Environmental Microbiology. 14: 1913-28. PMID 22176658 DOI: 10.1111/J.1462-2920.2011.02657.X |
0.332 |
|
| 2012 |
Koo J, Burrows LL, Howell PL. Decoding the roles of pilotins and accessory proteins in secretin escort services. Fems Microbiology Letters. 328: 1-12. PMID 22098485 DOI: 10.1111/J.1574-6968.2011.02464.X |
0.458 |
|
| 2011 |
Tammam S, Sampaleanu LM, Koo J, Sundaram P, Ayers M, Chong PA, Forman-Kay JD, Burrows LL, Howell PL. Characterization of the PilN, PilO and PilP type IVa pilus subcomplex. Molecular Microbiology. 82: 1496-514. PMID 22053789 DOI: 10.1111/J.1365-2958.2011.07903.X |
0.807 |
|
| 2011 |
Franklin MJ, Nivens DE, Weadge JT, Howell PL. Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl. Frontiers in Microbiology. 2: 167. PMID 21991261 DOI: 10.3389/Fmicb.2011.00167 |
0.4 |
|
| 2011 |
Whitney JC, Hay ID, Li C, Eckford PD, Robinson H, Amaya MF, Wood LF, Ohman DE, Bear CE, Rehm BH, Howell PL. Structural basis for alginate secretion across the bacterial outer membrane. Proceedings of the National Academy of Sciences of the United States of America. 108: 13083-8. PMID 21778407 DOI: 10.1073/Pnas.1104984108 |
0.414 |
|
| 2011 |
Wehbi H, Portillo E, Harvey H, Shimkoff AE, Scheurwater EM, Howell PL, Burrows LL. The peptidoglycan-binding protein FimV promotes assembly of the Pseudomonas aeruginosa type IV pilus secretin. Journal of Bacteriology. 193: 540-50. PMID 21097635 DOI: 10.1128/Jb.01048-10 |
0.45 |
|
| 2011 |
Siu KK, Asmus K, Zhang AN, Horvatin C, Li S, Liu T, Moffatt B, Woods VL, Howell PL. Mechanism of substrate specificity in 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases. Journal of Structural Biology. 173: 86-98. PMID 20554051 DOI: 10.1016/J.Jsb.2010.06.006 |
0.372 |
|
| 2011 |
Howell PL, Tammam S, Chong PA, Forman-Kay J. Solution Structure of PilP from Pseudomonas aeruginosa Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Lc4/Pdb |
0.745 |
|
| 2010 |
Farrar CE, Siu KK, Howell PL, Jarrett JT. Biotin synthase exhibits burst kinetics and multiple turnovers in the absence of inhibition by products and product-related biomolecules. Biochemistry. 49: 9985-96. PMID 20961145 DOI: 10.1021/Bi101023C |
0.304 |
|
| 2010 |
Pell LG, Gasmi-Seabrook GM, Morais M, Neudecker P, Kanelis V, Bona D, Donaldson LW, Edwards AM, Howell PL, Davidson AR, Maxwell KL. The solution structure of the C-terminal Ig-like domain of the bacteriophage λ tail tube protein. Journal of Molecular Biology. 403: 468-79. PMID 20826161 DOI: 10.1016/J.Jmb.2010.08.044 |
0.41 |
|
| 2010 |
Ayers M, Howell PL, Burrows LL. Architecture of the type II secretion and type IV pilus machineries. Future Microbiology. 5: 1203-18. PMID 20722599 DOI: 10.2217/Fmb.10.76 |
0.405 |
|
| 2010 |
Keiski CL, Harwich M, Jain S, Neculai AM, Yip P, Robinson H, Whitney JC, Riley L, Burrows LL, Ohman DE, Howell PL. AlgK is a TPR-containing protein and the periplasmic component of a novel exopolysaccharide secretin. Structure (London, England : 1993). 18: 265-73. PMID 20159471 DOI: 10.1016/J.Str.2009.11.015 |
0.47 |
|
| 2009 |
Sampaleanu LM, Bonanno JB, Ayers M, Koo J, Tammam S, Burley SK, Almo SC, Burrows LL, Howell PL. Periplasmic domains of Pseudomonas aeruginosa PilN and PilO form a stable heterodimeric complex. Journal of Molecular Biology. 394: 143-59. PMID 19857646 DOI: 10.1016/J.Jmb.2009.09.037 |
0.796 |
|
| 2009 |
Ayers M, Sampaleanu LM, Tammam S, Koo J, Harvey H, Howell PL, Burrows LL. PilM/N/O/P proteins form an inner membrane complex that affects the stability of the Pseudomonas aeruginosa type IV pilus secretin. Journal of Molecular Biology. 394: 128-42. PMID 19857645 DOI: 10.1016/J.Jmb.2009.09.034 |
0.795 |
|
| 2009 |
Pell LG, Liu A, Edmonds L, Donaldson LW, Howell PL, Davidson AR. The X-ray crystal structure of the phage lambda tail terminator protein reveals the biologically relevant hexameric ring structure and demonstrates a conserved mechanism of tail termination among diverse long-tailed phages. Journal of Molecular Biology. 389: 938-51. PMID 19426744 DOI: 10.1016/J.Jmb.2009.04.072 |
0.454 |
|
| 2009 |
Whitney JC, Neculai AM, Ohman DE, Howell PL. Expression, refolding, crystallization and preliminary X-ray analysis of Pseudomonas aeruginosa AlgE. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 463-6. PMID 19407377 DOI: 10.1107/S174430910901094X |
0.31 |
|
| 2009 |
Pell LG, Kanelis V, Donaldson LW, Howell PL, Davidson AR. The phage lambda major tail protein structure reveals a common evolution for long-tailed phages and the type VI bacterial secretion system. Proceedings of the National Academy of Sciences of the United States of America. 106: 4160-5. PMID 19251647 DOI: 10.1073/Pnas.0900044106 |
0.452 |
|
| 2008 |
Koo J, Tammam S, Ku SY, Sampaleanu LM, Burrows LL, Howell PL. PilF is an outer membrane lipoprotein required for multimerization and localization of the Pseudomonas aeruginosa Type IV pilus secretin. Journal of Bacteriology. 190: 6961-9. PMID 18776008 DOI: 10.1128/Jb.00996-08 |
0.797 |
|
| 2008 |
Siu KK, Lee JE, Sufrin JR, Moffatt BA, McMillan M, Cornell KA, Isom C, Howell PL. Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases. Journal of Molecular Biology. 378: 112-28. PMID 18342331 DOI: 10.1016/J.Jmb.2008.01.088 |
0.387 |
|
| 2008 |
Chiang P, Sampaleanu LM, Ayers M, Pahuta M, Howell PL, Burrows LL. Functional role of conserved residues in the characteristic secretion NTPase motifs of the Pseudomonas aeruginosa type IV pilus motor proteins PilB, PilT and PilU. Microbiology (Reading, England). 154: 114-26. PMID 18174131 DOI: 10.1099/Mic.0.2007/011320-0 |
0.804 |
|
| 2007 |
Ku SY, Cornell KA, Howell PL. Structure of Arabidopsis thaliana 5-methylthioribose kinase reveals a more occluded active site than its bacterial homolog. Bmc Structural Biology. 7: 70. PMID 17961230 DOI: 10.1186/1472-6807-7-70 |
0.3 |
|
| 2007 |
Tsai M, Koo J, Yip P, Colman RF, Segall ML, Howell PL. Substrate and product complexes of Escherichia coli adenylosuccinate lyase provide new insights into the enzymatic mechanism. Journal of Molecular Biology. 370: 541-54. PMID 17531264 DOI: 10.1016/J.Jmb.2007.04.052 |
0.305 |
|
| 2007 |
Ku SY, Yip P, Cornell KA, Riscoe MK, Behr JB, Guillerm G, Howell PL. Structures of 5-methylthioribose kinase reveal substrate specificity and unusual mode of nucleotide binding. The Journal of Biological Chemistry. 282: 22195-206. PMID 17522047 DOI: 10.1074/Jbc.M611045200 |
0.373 |
|
| 2007 |
Smith GD, Lemke CT, Howell PL. Substructure determination in multiwavelength anomalous diffraction, single anomalous diffraction, and single isomorphous replacement with anomalous scattering data using Shake-and-Bake. Methods in Molecular Biology (Clifton, N.J.). 364: 183-96. PMID 17172766 DOI: 10.1385/1-59745-266-1:183 |
0.675 |
|
| 2005 |
Lee JE, Smith GD, Horvatin C, Huang DJ, Cornell KA, Riscoe MK, Howell PL. Structural snapshots of MTA/AdoHcy nucleosidase along the reaction coordinate provide insights into enzyme and nucleoside flexibility during catalysis. Journal of Molecular Biology. 352: 559-74. PMID 16109423 DOI: 10.1016/J.Jmb.2005.07.027 |
0.394 |
|
| 2005 |
Lee JE, Luong W, Huang DJ, Cornell KA, Riscoe MK, Howell PL. Mutational analysis of a nucleosidase involved in quorum-sensing autoinducer-2 biosynthesis. Biochemistry. 44: 11049-57. PMID 16101288 DOI: 10.1021/Bi050493Q |
0.396 |
|
| 2005 |
Tsai M, Koo J, Howell PL. Recovery of argininosuccinate lyase activity in duck delta1 crystallin. Biochemistry. 44: 9034-44. PMID 15966727 DOI: 10.1021/Bi050346S |
0.423 |
|
| 2005 |
Lee JE, Singh V, Evans GB, Tyler PC, Furneaux RH, Cornell KA, Riscoe MK, Schramm VL, Howell PL. Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. The Journal of Biological Chemistry. 280: 18274-82. PMID 15746096 DOI: 10.1074/Jbc.M414471200 |
0.331 |
|
| 2004 |
Tsai M, Sampaleanu LM, Greene C, Creagh L, Haynes C, Howell PL. A duck delta1 crystallin double loop mutant provides insight into residues important for argininosuccinate lyase activity. Biochemistry. 43: 11672-82. PMID 15362851 DOI: 10.1021/Bi0489006 |
0.794 |
|
| 2004 |
Sampaleanu LM, Codding PW, Lobsanov YD, Tsai M, Smith GD, Horvatin C, Howell PL. Structural studies of duck delta2 crystallin mutants provide insight into the role of Thr161 and the 280s loop in catalysis. The Biochemical Journal. 384: 437-47. PMID 15320872 DOI: 10.1042/Bj20040656 |
0.791 |
|
| 2004 |
Yu B, Paroutis P, Davidson AR, Howell PL. Disruption of a salt bridge dramatically accelerates subunit exchange in duck delta2 crystallin. The Journal of Biological Chemistry. 279: 40972-9. PMID 15273245 DOI: 10.1074/Jbc.M405300200 |
0.419 |
|
| 2004 |
Lee JE, Settembre EC, Cornell KA, Riscoe MK, Sufrin JR, Ealick SE, Howell PL. Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design. Biochemistry. 43: 5159-69. PMID 15122881 DOI: 10.1021/Bi035492H |
0.364 |
|
| 2004 |
Lobsanov YD, Romero PA, Sleno B, Yu B, Yip P, Herscovics A, Howell PL. Structure of Kre2p/Mnt1p: a yeast alpha1,2-mannosyltransferase involved in mannoprotein biosynthesis. The Journal of Biological Chemistry. 279: 17921-31. PMID 14752117 DOI: 10.1074/Jbc.M312720200 |
0.413 |
|
| 2002 |
Lemke CT, Smith GD, Howell PL. S-SAD, Se-SAD and S/Se-SIRAS using Cu Kalpha radiation: why wait for synchrotron time? Acta Crystallographica. Section D, Biological Crystallography. 58: 2096-101. PMID 12454470 DOI: 10.1107/S0907444902018838 |
0.696 |
|
| 2002 |
Lemke CT, Howell PL. Substrate induced conformational changes in argininosuccinate synthetase. The Journal of Biological Chemistry. 277: 13074-81. PMID 11809762 DOI: 10.1074/Jbc.M112436200 |
0.744 |
|
| 2002 |
Sampaleanu LM, Yu B, Howell PL. Mutational analysis of duck delta 2 crystallin and the structure of an inactive mutant with bound substrate provide insight into the enzymatic mechanism of argininosuccinate lyase. The Journal of Biological Chemistry. 277: 4166-75. PMID 11698398 DOI: 10.1074/Jbc.M107465200 |
0.798 |
|
| 2001 |
Yu B, Thompson GD, Yip P, Howell PL, Davidson AR. Mechanisms for intragenic complementation at the human argininosuccinate lyase locus. Biochemistry. 40: 15581-90. PMID 11747433 DOI: 10.1021/Bi011526E |
0.381 |
|
| 2001 |
Sampaleanu LM, Vallée F, Thompson GD, Howell PL. Three-dimensional structure of the argininosuccinate lyase frequently complementing allele Q286R. Biochemistry. 40: 15570-80. PMID 11747432 DOI: 10.1021/bi011525m |
0.775 |
|
| 2001 |
Lemke CT, Howell PL. The 1.6 A crystal structure of E. coli argininosuccinate synthetase suggests a conformational change during catalysis. Structure (London, England : 1993). 9: 1153-64. PMID 11738042 DOI: 10.1016/S0969-2126(01)00683-9 |
0.701 |
|
| 2001 |
Sampaleanu LM, Vallée F, Slingsby C, Howell PL. Structural studies of duck delta 1 and delta 2 crystallin suggest conformational changes occur during catalysis. Biochemistry. 40: 2732-42. PMID 11258884 DOI: 10.1021/BI002272K |
0.78 |
|
| 2000 |
Turner MA, Yang X, Yin D, Kuczera K, Borchardt RT, Howell PL. Structure and function of S-adenosylhomocysteine hydrolase. Cell Biochemistry and Biophysics. 33: 101-25. PMID 11325033 DOI: 10.1385/Cbb:33:2:101 |
0.383 |
|
| 2000 |
Vallée F, Lipari F, Yip P, Sleno B, Herscovics A, Howell PL. Crystal structure of a class I alpha1,2-mannosidase involved in N-glycan processing and endoplasmic reticulum quality control. The Embo Journal. 19: 581-8. PMID 10675327 DOI: 10.1093/Emboj/19.4.581 |
0.37 |
|
| 1999 |
Lemke C, Yeung M, Howell PL. Expression, purification, crystallization and preliminary X-ray analysis of Escherichia coli argininosuccinate synthetase. Acta Crystallographica. Section D, Biological Crystallography. 55: 2028-30. PMID 10666579 DOI: 10.1107/S0907444999011816 |
0.677 |
|
| 1999 |
Sampaleanu LM, Davidson AR, Graham C, Wistow GJ, Howell PL. Domain exchange experiments in duck delta-crystallins: functional and evolutionary implications. Protein Science : a Publication of the Protein Society. 8: 529-37. PMID 10091655 DOI: 10.1110/ps.8.3.529 |
0.789 |
|
| 1997 |
Abu-Abed M, Turner MA, Vallée F, Simpson A, Slingsby C, Howell PL. Structural comparison of the enzymatically active and inactive forms of delta crystallin and the role of histidine 91. Biochemistry. 36: 14012-22. PMID 9369472 DOI: 10.1021/Bi971407S |
0.365 |
|
| 1997 |
Dole K, Lipari F, Herscovics A, Howell PL. Crystallization and preliminary X-ray analysis of the class 1 α1,2- mannosidase from Saccharomyces cerevisiae Journal of Structural Biology. 120: 69-72. PMID 9356293 DOI: 10.1006/Jsbi.1997.3903 |
0.324 |
|
| 1994 |
Abu-Abed M, Turner MA, Atkinson J, Dole K, Howell PL. Crystallization and preliminary X-ray analysis of a mutant duck delta II crystallin. Journal of Molecular Biology. 243: 944-6. PMID 7966310 DOI: 10.1006/Jmbi.1994.1694 |
0.318 |
|
| 1992 |
Howell PL, Warren C, Amatayakul-Chantler S, Petsko GA, Hajdu J. Activity of crystalline turkey egg white lysozyme. Proteins. 12: 91-9. PMID 1553384 DOI: 10.1002/Prot.340120111 |
0.43 |
|
| 1992 |
Howell PL, Almo SC, Parsons MR, Hajdu J, Petsko GA. Structure determination of turkey egg-white lysozyme using Laue diffraction data. Acta Crystallographica. Section B, Structural Science. 48: 200-7. PMID 1515108 DOI: 10.1107/S0108768191012466 |
0.612 |
|
| 1991 |
Neidhart DJ, Howell PL, Petsko GA, Powers VM, Li RS, Kenyon GL, Gerlt JA. Mechanism of the reaction catalyzed by mandelate racemase. 2. Crystal structure of mandelate racemase at 2.5-A resolution: identification of the active site and possible catalytic residues. Biochemistry. 30: 9264-73. PMID 1892834 DOI: 10.1021/Bi00102A019 |
0.475 |
|
| 1990 |
Neidhart DC, Howell PL, Petsko GA, Gerlt JA, Kozarich JW, Powers VM, Kenyon GL. Restructuring catalysis in the mandelate pathway. Biochemical Society Symposium. 57: 135-41. PMID 2099737 |
0.421 |
|
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