Kenji Watanabe - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
 Hokkaido University, Sapporo-shi, Hokkaidō, Japan 
 2010- University of Shizuoka, Shizuoka-shi, Shizuoka-ken, Japan 

131 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Hayakawa I, Isogai T, Takanishi J, Asai S, Ando C, Tsutsumi T, Watanabe K, Sakakura A, Tsunematsu Y. Synthesis and biological evaluation of coprinoferrin, an acylated tripeptide hydroxamate siderophore. Organic & Biomolecular Chemistry. PMID 38175167 DOI: 10.1039/d3ob01850d  0.673
2023 Iwasaka C, Ninomiya Y, Nakagata T, Nanri H, Watanabe D, Ohno H, Tanisawa K, Konishi K, Murakami H, Tsunematsu Y, Sato M, Watanabe K, Miyachi M. Association between physical activity and the prevalence of tumorigenic bacteria in the gut microbiota of Japanese adults: a cross-sectional study. Scientific Reports. 13: 20841. PMID 38012174 DOI: 10.1038/s41598-023-47442-9  0.626
2023 Niwa K, Ohashi M, Xie K, Chiang CY, Jamieson CS, Sato M, Watanabe K, Liu F, Houk KN, Tang Y. Biosynthesis of Polycyclic Natural Products from Conjugated Polyenes via Tandem Isomerization and Pericyclic Reactions. Journal of the American Chemical Society. 145: 13520-13525. PMID 37310230 DOI: 10.1021/jacs.3c02380  0.472
2023 Kato M, Yamaguchi M, Ooka A, Takahashi R, Suzuki T, Onoda K, Yoshikawa Y, Tsunematsu Y, Sato M, Yoshioka Y, Igarashi M, Hayakawa S, Shoji K, Shoji Y, Ishikawa T, ... Watanabe K, et al. Non-target GC-MS analyses of fecal VOCs in NASH-hepatocellular carcinoma model STAM mice. Scientific Reports. 13: 8924. PMID 37264108 DOI: 10.1038/s41598-023-36091-7  0.612
2023 Onoda K, Kato M, Tsunematsu Y, Eto F, Sato M, Yoshioka Y, Yoshida T, Tamura K, Yao I, Dohra H, Watanabe K, Miyoshi N. Biosynthetic Gene Expression and Tissue Distribution of Diosgenin in . Journal of Agricultural and Food Chemistry. 71: 4292-4297. PMID 36753603 DOI: 10.1021/acs.jafc.2c08478  0.659
2023 Kishimoto S, Minami A, Aoki Y, Matsubara Y, Watanabe S, Watanabe K. Reactive Azlactone Intermediate Drives Fungal Secondary Metabolite Cross-Pathway Generation. Journal of the American Chemical Society. PMID 36706030 DOI: 10.1021/jacs.2c13188  0.335
2022 Watanabe K, Sato M, Osada H. Recent advances in the chemo-biological characterization of decalin natural products and unraveling of the workings of Diels-Alderases. Fungal Biology and Biotechnology. 9: 9. PMID 35488322 DOI: 10.1186/s40694-022-00139-6  0.304
2022 Kishimoto S, Matsubara Y, Watanabe K. Alkaloid Biosynthetic Enzyme Generates Diastereomeric Pair Two Distinct Mechanisms. Journal of the American Chemical Society. 144: 5485-5493. PMID 35302734 DOI: 10.1021/jacs.1c13621  0.338
2022 Ito A, Choi JH, Yokoyama-Maruyama W, Kotajima M, Wu J, Suzuki T, Terashima Y, Suzuki H, Hirai H, Nelson DC, Tsunematsu Y, Watanabe K, Asakawa T, Ouchi H, Inai M, et al. 1,2,3-Triazine formation mechanism of the fairy chemical 2-azahypoxanthine in the fairy ring-forming fungus . Organic & Biomolecular Chemistry. PMID 35293930 DOI: 10.1039/d2ob00328g  0.69
2022 Narita T, Tsunematsu Y, Miyoshi N, Komiya M, Hamoya T, Fujii G, Yoshikawa Y, Sato M, Kawanishi M, Sugimura H, Iwashita Y, Totsuka Y, Terasaki M, Watanabe K, Wakabayashi K, et al. Induction of DNA Damage in Mouse Colorectum by Administration of Colibactin-producing , Isolated from a Patient With Colorectal Cancer. In Vivo (Athens, Greece). 36: 628-634. PMID 35241515 DOI: 10.21873/invivo.12746  0.629
2021 Sato M, Kishimoto S, Yokoyama M, Jamieson CS, Narita K, Maeda N, Hara K, Hashimoto H, Tsunematsu Y, Houk KN, Tang Y, Watanabe K. Catalytic mechanism and -to- selectivity reversion of an octalin-forming natural Diels-Alderase. Nature Catalysis. 4: 223-232. PMID 35873532 DOI: 10.1038/s41929-021-00577-2  0.73
2021 Matsuda S, Tsunematsu Y, Matsushita T, Ogata Y, Hachiya S, Kishimoto S, Miyoshi N, Watanabe K. Toward engineered biosynthesis of drugs in human cells. Chembiochem : a European Journal of Chemical Biology. PMID 34889017 DOI: 10.1002/cbic.202100645  0.68
2021 Iwasaki M, Kanehara R, Yamaji T, Katagiri R, Mutoh M, Tsunematsu Y, Sato M, Watanabe K, Hosomi K, Kakugawa Y, Ikematsu H, Hotta K, Kunisawa J, Wakabayashi K, Matsuda T. Association of Escherichia coli containing polyketide synthase in the gut microbiota with colorectal neoplasia in Japan. Cancer Science. PMID 34779109 DOI: 10.1111/cas.15196  0.642
2021 Tsunematsu Y, Hosomi K, Kunisawa J, Sato M, Shibuya N, Saito E, Murakami H, Yoshikawa Y, Iwashita Y, Miyoshi N, Mutoh M, Ishikawa H, Sugimura H, Miyachi M, Wakabayashi K, ... Watanabe K, et al. Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria. Bmc Microbiology. 21: 235. PMID 34429063 DOI: 10.1186/s12866-021-02292-1  0.655
2021 Watanabe D, Murakami H, Ohno H, Tanisawa K, Konishi K, Todoroki-Mori K, Tsunematsu Y, Sato M, Ogata Y, Miyoshi N, Kubota N, Kunisawa J, Wakabayashi K, Kubota T, Watanabe K, et al. Stool pattern is associated with not only the prevalence of tumorigenic bacteria isolated from fecal matter but also plasma and fecal fatty acids in healthy Japanese adults. Bmc Microbiology. 21: 196. PMID 34182940 DOI: 10.1186/s12866-021-02255-6  0.641
2021 Liu M, Ohashi M, Hung YS, Scherlach K, Watanabe K, Hertweck C, Tang Y. AoiQ Catalyzes Geminal Dichlorination of 1,3-Diketone Natural Products. Journal of the American Chemical Society. PMID 33957045 DOI: 10.1021/jacs.1c02868  0.559
2021 Zhou T, Hirayama Y, Tsunematsu Y, Suzuki N, Tanaka S, Uchiyama N, Goda Y, Yoshikawa Y, Iwashita Y, Sato M, Miyoshi N, Mutoh M, Ishikawa H, Sugimura H, Wakabayashi K, ... Watanabe K, et al. Isolation of New Colibactin Metabolites from Wild-Type and Trapping of a Mature Colibactin Derivative. Journal of the American Chemical Society. PMID 33787233 DOI: 10.1021/jacs.1c01495  0.702
2021 Kobayashi T, Toyoda T, Tajima Y, Kishimoto S, Tsunematsu Y, Sato M, Matsushita K, Yamada T, Shimamura Y, Masuda S, Ochiai M, Ogawa K, Watanabe K, Takamura-Enya T, Totsuka Y, et al. -Anisidine Dimer, 2-Methoxy--(2-methoxyphenyl) Benzene-1,4-diamine, in Rat Urine Associated with Urinary bladder Carcinogenesis. Chemical Research in Toxicology. PMID 33587850 DOI: 10.1021/acs.chemrestox.0c00536  0.654
2020 Zhang Z, Tamura Y, Tang M, Qiao T, Sato M, Otsu Y, Sasamura S, Taniguchi M, Watanabe K, Tang Y. Biosynthesis of the Immunosuppressant (-)-FR901483. Journal of the American Chemical Society. PMID 33372776 DOI: 10.1021/jacs.0c12352  0.41
2020 Tsunematsu Y, Maeda N, Sato M, Hara K, Hashimoto H, Watanabe K, Hertweck C. Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis. Journal of the American Chemical Society. PMID 33351612 DOI: 10.1021/jacs.0c08879  0.758
2020 Matsushita T, Kishimoto S, Hara K, Hashimoto H, Watanabe K. Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidase from Fungal Natural Product Biosynthesis. Biochemistry. 59: 4787-4792. PMID 33332106 DOI: 10.1021/acs.biochem.0c00896  0.309
2020 Watanabe D, Murakami H, Ohno H, Tanisawa K, Konishi K, Tsunematsu Y, Sato M, Miyoshi N, Wakabayashi K, Watanabe K, Miyachi M. Association between dietary intake and the prevalence of tumourigenic bacteria in the gut microbiota of middle-aged Japanese adults. Scientific Reports. 10: 15221. PMID 32939005 DOI: 10.1038/S41598-020-72245-7  0.654
2020 Zhang Z, Qiao T, Watanabe K, Tang Y. Concise biosynthesis of phenylfuropyridones from fungi. Angewandte Chemie (International Ed. in English). PMID 32779306 DOI: 10.1002/Anie.202008321  0.519
2020 Asai S, Tsunematsu Y, Masuya T, Otaka J, Osada H, Watanabe K. Uncovering hidden sesquiterpene biosynthetic pathway through expression boost area-mediated productivity enhancement in basidiomycete. The Journal of Antibiotics. PMID 32759961 DOI: 10.1038/S41429-020-0355-9  0.737
2020 Yoshikawa Y, Tsunematsu Y, Matsuzaki N, Hirayama Y, Higashiguchi F, Sato M, Iwashita Y, Miyoshi N, Mutoh M, Ishikawa H, Sugimura H, Wakabayashi K, Watanabe K. Characterization of colibactin-producing Escherichia coli isolated from Japanese patients with colorectal cancer. Japanese Journal of Infectious Diseases. PMID 32475872 DOI: 10.7883/Yoken.Jjid.2020.066  0.65
2020 Uchikawa M, Kato M, Nagata A, Sanada S, Yoshikawa Y, Tsunematsu Y, Sato M, Suzuki T, Hashidume T, Watanabe K, Yoshikawa Y, Miyoshi N. Elevated levels of proinflammatory volatile metabolites in feces of high fat diet fed KK-A mice. Scientific Reports. 10: 5681. PMID 32231228 DOI: 10.1038/S41598-020-62541-7  0.638
2020 Kawanishi M, Shimohara C, Oda Y, Hisatomi Y, Tsunematsu Y, Sato M, Hirayama Y, Miyoshi N, Iwashita Y, Yoshikawa Y, Sugimura H, Mutoh M, Ishikawa H, Wakabayashi K, Yagi T, ... Watanabe K, et al. Genotyping of a gene cluster for production of colibactin and in vitro genotoxicity analysis of strains obtained from the Japan Collection of Microorganisms. Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society. 42: 12. PMID 32175032 DOI: 10.1186/S41021-020-00149-Z  0.692
2020 Sarmales-Murga C, Akaoka F, Sato M, Takanishi J, Mino T, Miyoshi N, Watanabe K. A new class of dimeric product isolated from the fungus Chaetomium globosum: evaluation of chemical structure and biological activity. The Journal of Antibiotics. PMID 32024969 DOI: 10.1038/S41429-020-0281-X  0.386
2019 Kawanishi M, Hisatomi Y, Oda Y, Shimohara C, Tsunematsu Y, Sato M, Hirayama Y, Miyoshi N, Iwashita Y, Yoshikawa Y, Sugimura H, Mutoh M, Ishikawa H, Wakabayashi K, Yagi T, ... Watanabe K, et al. In vitro genotoxicity analyses of colibactin-producing E. coli isolated from a Japanese colorectal cancer patient. The Journal of Toxicological Sciences. 44: 871-876. PMID 31813906 DOI: 10.2131/Jts.44.871  0.677
2019 Tsunematsu Y, Takanishi J, Asai S, Masuya T, Nakazawa T, Watanabe K. Genomic Mushroom Hunting Decrypts Coprinoferrin, A Siderophore Secondary Metabolite Vital to Fungal Cell Development. Organic Letters. PMID 31496254 DOI: 10.1021/Acs.Orglett.9B02861  0.701
2019 Kishimoto S, Tsunematsu Y, Matsushita T, Hara K, Hashimoto H, Tang Y, Watanabe K. Functional and Structural Analyses of trans C-Methyltransferase in Fungal Polyketide Biosynthesis. Biochemistry. PMID 31486637 DOI: 10.1021/Acs.Biochem.9B00702  0.758
2019 Hirayama Y, Tsunematsu Y, Yoshikawa Y, Tamafune R, Matsuzaki N, Iwashita Y, Ohnishi I, Tanioka F, Sato M, Miyoshi N, Mutoh M, Ishikawa H, Sugimura H, Wakabayashi K, Watanabe K. Activity-Based Probe for Screening of High-Colibactin Producers from Clinical Samples. Organic Letters. PMID 31192617 DOI: 10.1021/Acs.Orglett.9B01345  0.665
2019 Masuya T, Tsunematsu Y, Hirayama Y, Sato M, Noguchi H, Nakazawa T, Watanabe K. Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions. Organic & Biomolecular Chemistry. 17: 234-239. PMID 30556075 DOI: 10.1039/C8Ob02814A  0.704
2018 Tsunematsu Y, Maeda N, Yokoyama M, Chankhamjon P, Watanabe K, Scherlach K, Hertweck C. Enzymatic Amide Tailoring Expedites Unusual Retro-Aldol-Type Amino Acid Conversion to Form Antifungal Cyclopeptide. Angewandte Chemie (International Ed. in English). PMID 30109903 DOI: 10.1002/Anie.201806740  0.747
2018 Kishimoto S, Hara K, Hashimoto H, Hirayama Y, Champagne PA, Houk KN, Tang Y, Watanabe K. Enzymatic one-step ring contraction for quinolone biosynthesis. Nature Communications. 9: 2826. PMID 30026518 DOI: 10.1038/S41467-018-05221-5  0.598
2018 Li L, Tang MC, Tang S, Gao SS, Soliman SSM, Hang L, Xu W, Ye T, Watanabe K, Tang Y. Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids. Journal of the American Chemical Society. PMID 29373009 DOI: 10.1021/Jacs.8B00056  0.48
2017 Nakazawa T, Izuno A, Horii M, Kodera R, Nishimura H, Hirayama Y, Tsunematsu Y, Miyazaki Y, Awano T, Muraguchi H, Watanabe K, Sakamoto M, Takabe K, Watanabe T, Isagi Y, et al. Effects of pex1 disruption on wood lignin biodegradation, fruiting development and the utilization of carbon sources in the white-rot Agaricomycete Pleurotus ostreatus and non-wood decaying Coprinopsis cinerea. Fungal Genetics and Biology : Fg & B. PMID 29030267 DOI: 10.1016/J.Fgb.2017.10.002  0.679
2017 Suwama T, Watanabe K, Monthakantirat O, Luecha P, Noguchi H, Watanabe K, Umehara K. Naphthalene glycosides in the Thai medicinal plant Diospyros mollis. Journal of Natural Medicines. PMID 29019024 DOI: 10.1007/S11418-017-1134-1  0.311
2017 Ohashi M, Liu F, Hai Y, Chen M, Tang MC, Yang Z, Sato M, Watanabe K, Houk KN, Tang Y. SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis. Nature. PMID 28902839 DOI: 10.1038/Nature23882  0.628
2017 Kishimoto S, Tsunematsu Y, Sato M, Watanabe K. Elucidation of biosynthetic pathways of natural products. Chemical Record (New York, N.Y.). PMID 28387469 DOI: 10.1002/Tcr.201700015  0.744
2017 Sato M, Dander JE, Sato C, Hung YS, Gao SS, Tang MC, Hang L, Winter JM, Garg NK, Watanabe K, Tang Y. Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases. Journal of the American Chemical Society. PMID 28365998 DOI: 10.1021/Jacs.7B02432  0.504
2017 Yokoyama M, Hirayama Y, Yamamoto T, Kishimoto S, Tsunematsu Y, Watanabe K. Integration of Chemical, Genetic, and Bioinformatic Approaches Delineates Fungal Polyketide-Peptide Hybrid Biosynthesis. Organic Letters. PMID 28361537 DOI: 10.1021/Acs.Orglett.7B00559  0.713
2017 Zou Y, Garcia-Borràs M, Tang MC, Hirayama Y, Li DH, Li L, Watanabe K, Houk KN, Tang Y. Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis. Nature Chemical Biology. PMID 28114276 DOI: 10.1038/Nchembio.2283  0.633
2016 Li L, Yu P, Tang MC, Zou Y, Gao SS, Hung YS, Zhao M, Watanabe K, Houk KN, Tang Y. Biochemical Characterization of a Eukaryotic Decalin-Forming Diels-Alderase. Journal of the American Chemical Society. 138: 15837-15840. PMID 27960349 DOI: 10.1021/Jacs.6B10452  0.545
2016 Tang MC, Zou Y, Watanabe K, Walsh CT, Tang Y. Oxidative Cyclization in Natural Product Biosynthesis. Chemical Reviews. PMID 27936626 DOI: 10.1021/Acs.Chemrev.6B00478  0.491
2016 Chankhamjon P, Tsunematsu Y, Ishida-Ito M, Sasa Y, Meyer F, Boettger-Schmidt D, Urbansky B, Menzel KD, Scherlach K, Watanabe K, Hertweck C. Regioselective Dichlorination of a Non-Activated Aliphatic Carbon Atom and Phenolic Bismethylation by a Multifunctional Fungal Flavoenzyme. Angewandte Chemie (International Ed. in English). PMID 27559694 DOI: 10.1002/Anie.201604516  0.754
2016 Kishimoto S, Sato M, Tsunematsu Y, Watanabe K. Evaluation of Biosynthetic Pathway and Engineered Biosynthesis of Alkaloids. Molecules (Basel, Switzerland). 21. PMID 27548127 DOI: 10.3390/Molecules21081078  0.732
2016 Kato H, Tsunematsu Y, Yamamoto T, Namiki T, Kishimoto S, Noguchi H, Watanabe K. New natural products isolated from Metarhizium robertsii ARSEF 23 by chemical screening and identification of the gene cluster through engineered biosynthesis in Aspergillus nidulans A1145. The Journal of Antibiotics. PMID 27189118 DOI: 10.1038/Ja.2016.54  0.713
2016 Yamamoto T, Tsunematsu Y, Hara K, Suzuki T, Kishimoto S, Kawagishi H, Noguchi H, Hashimoto H, Tang Y, Hotta K, Watanabe K. Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis. Angewandte Chemie (International Ed. in English). PMID 27072782 DOI: 10.1002/Anie.201600940  0.761
2016 Sato M, Winter JM, Kishimoto S, Noguchi H, Tang Y, Watanabe K. Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin Biosynthesis. Organic Letters. PMID 26959241 DOI: 10.1021/Acs.Orglett.6B00380  0.643
2015 Yamamoto T, Tsunematsu Y, Noguchi H, Hotta K, Watanabe K. Elucidation of Pyranonigrin Biosynthetic Pathway Reveals a Mode of Tetramic Acid, Fused γ-Pyrone, and exo-Methylene Formation. Organic Letters. PMID 26414728 DOI: 10.1021/Acs.Orglett.5B02435  0.739
2015 Sato M, Yagishita F, Mino T, Uchiyama N, Patel A, Chooi YH, Goda Y, Xu W, Noguchi H, Yamamoto T, Hotta K, Houk KN, Tang Y, Watanabe K. Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition. Chembiochem : a European Journal of Chemical Biology. PMID 26360642 DOI: 10.1002/Cbic.201500386  0.615
2015 Winter JM, Cascio D, Dietrich D, Sato M, Watanabe K, Sawaya MR, Vederas JC, Tang Y. Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis. Journal of the American Chemical Society. PMID 26172141 DOI: 10.1021/Jacs.5B04520  0.48
2015 Zou Y, Zhan Z, Li D, Tang M, Cacho RA, Watanabe K, Tang Y. Tandem prenyltransferases catalyze isoprenoid elongation and complexity generation in biosynthesis of quinolone alkaloids. Journal of the American Chemical Society. 137: 4980-3. PMID 25859931 DOI: 10.1021/Jacs.5B03022  0.623
2015 Wong FT, Hotta K, Chen X, Fang M, Watanabe K, Kim CY. Epoxide hydrolase-lasalocid a structure provides mechanistic insight into polyether natural product biosynthesis. Journal of the American Chemical Society. 137: 86-9. PMID 25535803 DOI: 10.1021/Ja511374K  0.406
2015 Sato M, Yamada H, Hotta K, Watanabe K. Elucidation of the shanorellin biosynthetic pathway and functional analysis of associated enzymes Medchemcomm. 6: 425-430. DOI: 10.1039/C4Md00352G  0.436
2014 Zou Y, Xu W, Tsunematsu Y, Tang M, Watanabe K, Tang Y. Methylation-dependent acyl transfer between polyketide synthase and nonribosomal peptide synthetase modules in fungal natural product biosynthesis. Organic Letters. 16: 6390-3. PMID 25494235 DOI: 10.1021/Ol503179V  0.754
2014 Watanabe K. Effective use of heterologous hosts for characterization of biosynthetic enzymes allows production of natural products and promotes new natural product discovery. Chemical & Pharmaceutical Bulletin. 62: 1153-65. PMID 25450623 DOI: 10.1248/Cpb.C14-00471  0.477
2014 Ishikawa N, Tanaka H, Koyama F, Noguchi H, Wang CC, Hotta K, Watanabe K. Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alkaloids. Angewandte Chemie (International Ed. in English). 53: 12880-4. PMID 25251934 DOI: 10.1002/Anie.201407920  0.559
2014 Tsunematsu Y, Fukutomi M, Saruwatari T, Noguchi H, Hotta K, Tang Y, Watanabe K. Elucidation of pseurotin biosynthetic pathway points to trans-acting C-methyltransferase: generation of chemical diversity. Angewandte Chemie (International Ed. in English). 53: 8475-9. PMID 24939566 DOI: 10.1002/Anie.201404804  0.791
2014 Saruwatari T, Yagishita F, Mino T, Noguchi H, Hotta K, Watanabe K. Cytochrome P450 as dimerization catalyst in diketopiperazine alkaloid biosynthesis. Chembiochem : a European Journal of Chemical Biology. 15: 656-9. PMID 24677498 DOI: 10.1002/Cbic.201300751  0.421
2014 Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y. Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway. Journal of the American Chemical Society. 136: 4426-36. PMID 24568283 DOI: 10.1021/Ja500881E  0.771
2014 Hotta K, Keegan RM, Ranganathan S, Fang M, Bibby J, Winn MD, Sato M, Lian M, Watanabe K, Rigden DJ, Kim CY. Conversion of a disulfide bond into a thioacetal group during echinomycin biosynthesis. Angewandte Chemie (International Ed. in English). 53: 824-8. PMID 24302672 DOI: 10.1002/Anie.201307404  0.349
2013 Hiratsuka T, Koketsu K, Minami A, Kaneko S, Yamazaki C, Watanabe K, Oguri H, Oikawa H. Core assembly mechanism of quinocarcin/SF-1739: bimodular complex nonribosomal peptide synthetases for sequential mannich-type reactions. Chemistry & Biology. 20: 1523-35. PMID 24269153 DOI: 10.1016/J.Chembiol.2013.10.011  0.4
2013 Tsunematsu Y, Ishikawa N, Wakana D, Goda Y, Noguchi H, Moriya H, Hotta K, Watanabe K. Distinct mechanisms for spiro-carbon formation reveal biosynthetic pathway crosstalk. Nature Chemical Biology. 9: 818-25. PMID 24121553 DOI: 10.1038/Nchembio.1366  0.744
2013 Nakazawa T, Ishiuchi K, Sato M, Tsunematsu Y, Sugimoto S, Gotanda Y, Noguchi H, Hotta K, Watanabe K. Targeted disruption of transcriptional regulators in Chaetomium globosum activates biosynthetic pathways and reveals transcriptional regulator-like behavior of aureonitol. Journal of the American Chemical Society. 135: 13446-55. PMID 23941144 DOI: 10.1021/Ja405128K  0.74
2013 Sato M, Nakazawa T, Tsunematsu Y, Hotta K, Watanabe K. Echinomycin biosynthesis. Current Opinion in Chemical Biology. 17: 537-45. PMID 23856054 DOI: 10.1016/j.cbpa.2013.06.022  0.714
2013 Tsunematsu Y, Ishiuchi K, Hotta K, Watanabe K. Yeast-based genome mining, production and mechanistic studies of the biosynthesis of fungal polyketide and peptide natural products. Natural Product Reports. 30: 1139-49. PMID 23824111 DOI: 10.1039/C3Np70037B  0.737
2013 Minami A, Oguri H, Watanabe K, Oikawa H. Biosynthetic machinery of ionophore polyether lasalocid: enzymatic construction of polyether skeleton. Current Opinion in Chemical Biology. 17: 555-61. PMID 23796908 DOI: 10.1016/J.Cbpa.2013.06.004  0.383
2013 Ishiuchi K, Nakazawa T, Yagishita F, Mino T, Noguchi H, Hotta K, Watanabe K. Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis. Journal of the American Chemical Society. 135: 7371-7. PMID 23611317 DOI: 10.1021/Ja402828W  0.458
2013 Koketsu K, Minami A, Watanabe K, Oguri H, Oikawa H. The Pictet-Spengler mechanism involved in the biosynthesis of tetrahydroisoquinoline antitumor antibiotics: a novel function for a nonribosomal peptide synthetase. Methods in Enzymology. 516: 79-98. PMID 23034225 DOI: 10.1016/B978-0-12-394291-3.00026-5  0.391
2012 Winter JM, Sato M, Sugimoto S, Chiou G, Garg NK, Tang Y, Watanabe K. Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase. Journal of the American Chemical Society. 134: 17900-3. PMID 23072467 DOI: 10.1021/Ja3090498  0.609
2012 Tsunematsu Y, Ichinoseki S, Nakazawa T, Ishikawa N, Noguchi H, Hotta K, Watanabe K. Overexpressing transcriptional regulator in Chaetomium globosum activates a silent biosynthetic pathway: evaluation of shanorellin biosynthesis. The Journal of Antibiotics. 65: 377-80. PMID 22569160 DOI: 10.1038/Ja.2012.34  0.663
2012 Minami A, Shimaya M, Suzuki G, Migita A, Shinde SS, Sato K, Watanabe K, Tamura T, Oguri H, Oikawa H. Sequential enzymatic epoxidation involved in polyether lasalocid biosynthesis. Journal of the American Chemical Society. 134: 7246-9. PMID 22506807 DOI: 10.1021/Ja301386G  0.427
2012 Nakazawa T, Ishiuchi K, Praseuth A, Noguchi H, Hotta K, Watanabe K. Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce a novel polyketide. Chembiochem : a European Journal of Chemical Biology. 13: 855-61. PMID 22447538 DOI: 10.1002/Cbic.201200107  0.394
2012 Ishiuchi K, Nakazawa T, Ookuma T, Sugimoto S, Sato M, Tsunematsu Y, Ishikawa N, Noguchi H, Hotta K, Moriya H, Watanabe K. Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics. Chembiochem : a European Journal of Chemical Biology. 13: 846-54. PMID 22447505 DOI: 10.1002/Cbic.201100798  0.737
2012 Koketsu K, Minami A, Watanabe K, Oguri H, Oikawa H. Pictet-Spenglerase involved in tetrahydroisoquinoline antibiotic biosynthesis. Current Opinion in Chemical Biology. 16: 142-9. PMID 22409961 DOI: 10.1016/J.Cbpa.2012.02.021  0.372
2012 Hotta K, Chen X, Paton RS, Minami A, Li H, Swaminathan K, Mathews II, Watanabe K, Oikawa H, Houk KN, Kim CY. Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis. Nature. 483: 355-8. PMID 22388816 DOI: 10.1038/Nature10865  0.433
2011 Minami A, Migita A, Inada D, Hotta K, Watanabe K, Oguri H, Oikawa H. Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis. Organic Letters. 13: 1638-41. PMID 21375229 DOI: 10.1021/Ol200100E  0.327
2011 Saruwatari T, Praseuth AP, Sato M, Torikai K, Noguchi H, Watanabe K. A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases. The Journal of Antibiotics. 64: 9-17. PMID 21102597 DOI: 10.1038/Ja.2010.130  0.459
2011 Torikai K, Saruwatari T, Kitano T, Sano T, Nakane A, Noguchi H, Watanabe K. Practical Synthesis of DOPA Derivative for Biosynthetic Production of Potent Antitumor Natural Products, Saframycins and Ecteinascidin 743 Letters in Organic Chemistry. 8: 686-689. DOI: 10.2174/157017811799304160  0.343
2010 Hirose Y, Watanabe K, Minami A, Nakamura T, Oguri H, Oikawa H. Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics. The Journal of Antibiotics. 64: 117-22. PMID 21102595 DOI: 10.1038/Ja.2010.142  0.408
2010 Koketsu K, Watanabe K, Suda H, Oguri H, Oikawa H. Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms. Nature Chemical Biology. 6: 408-10. PMID 20453862 DOI: 10.1038/Nchembio.365  0.344
2010 Matsuura Y, Shichijo Y, Minami A, Migita A, Oguri H, Watanabe M, Tokiwano T, Watanabe K, Oikawa H. Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A. Organic Letters. 12: 2226-9. PMID 20394359 DOI: 10.1021/Ol100541E  0.386
2010 Chino A, Watanabe K, Moriya H. Plasmid Construction Using Recombination Activity in the Fission Yeast Schizosaccharomyces pombe Plos One. 5. PMID 20300182 DOI: 10.1371/Journal.Pone.0009652  0.31
2009 Pickens LB, Kim W, Wang P, Zhou H, Watanabe K, Gomi S, Tang Y. Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575. Journal of the American Chemical Society. 131: 17677-89. PMID 19908837 DOI: 10.1021/Ja907852C  0.623
2009 Watanabe K, Hotta K, Praseuth AP, Searcey M, Wang CC, Oguri H, Oikawa H. Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli. Chembiochem : a European Journal of Chemical Biology. 10: 1965-8. PMID 19588480 DOI: 10.1002/Cbic.200900260  0.547
2009 Watanabe K, Hotta K, Nakaya M, Praseuth AP, Wang CC, Inada D, Takahashi K, Fukushi E, Oguri H, Oikawa H. Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product. Journal of the American Chemical Society. 131: 9347-53. PMID 19514719 DOI: 10.1021/Ja902261A  0.613
2009 Bok JW, Chiang YM, Szewczyk E, Reyes-Dominguez Y, Davidson AD, Sanchez JF, Lo HC, Watanabe K, Strauss J, Oakley BR, Wang CC, Keller NP. Chromatin-level regulation of biosynthetic gene clusters. Nature Chemical Biology. 5: 462-4. PMID 19448638 DOI: 10.1038/Nchembio.177  0.482
2009 Watanabe K, Praseuth AP, Praseuth MB, Hotta K. Chapter 15. Plasmid-borne gene cluster assemblage and heterologous biosynthesis of nonribosomal peptides in Escherichia coli. Methods in Enzymology. 458: 379-99. PMID 19374991 DOI: 10.1016/S0076-6879(09)04815-0  0.477
2009 Watanabe K, Oguri H, Oikawa H. Diversification of echinomycin molecular structure by way of chemoenzymatic synthesis and heterologous expression of the engineered echinomycin biosynthetic pathway. Current Opinion in Chemical Biology. 13: 189-196. PMID 19278894 DOI: 10.1016/J.Cbpa.2009.02.012  0.388
2009 Migita A, Watanabe M, Hirose Y, Watanabe K, Tokiwano T, Kinashi H, Oikawa H. Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis. Bioscience, Biotechnology, and Biochemistry. 73: 169-76. PMID 19129623 DOI: 10.1271/Bbb.80631  0.422
2009 Watanabe K, Oguri H, Oikawa H. Enzymatic Synthesis of Molecular Skeletons of Complex Antitumor Antibiotics with Non-ribosomal Peptide Synthetases Journal of Synthetic Organic Chemistry, Japan. 67: 1152-1160. DOI: 10.5059/Yukigoseikyokaishi.67.1152  0.358
2008 Praseuth AP, Wang CC, Watanabe K, Hotta K, Oguri H, Oikawa H. Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus. Biotechnology Progress. 24: 1226-31. PMID 19194935 DOI: 10.1002/Btpr.34  0.537
2008 Watanabe K. Exploring the biosynthesis of natural products and their inherent suitability for the rational design of desirable compounds through genetic engineering. Bioscience, Biotechnology, and Biochemistry. 72: 2491-506. PMID 18838806 DOI: 10.1271/Bbb.80323  0.455
2008 Koketsu K, Oguri H, Watanabe K, Oikawa H. Enzymatic macrolactonization in the presence of DNA leading to triostin A analogs. Chemistry & Biology. 15: 818-28. PMID 18721753 DOI: 10.1016/J.Chembiol.2008.05.022  0.331
2008 Shichijo Y, Migita A, Oguri H, Watanabe M, Tokiwano T, Watanabe K, Oikawa H. Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis. Journal of the American Chemical Society. 130: 12230-12231. PMID 18710235 DOI: 10.1021/Ja8040543  0.428
2008 Zhan J, Watanabe K, Tang Y. Synergistic actions of a monooxygenase and cyclases in aromatic polyketide biosynthesis. Chembiochem : a European Journal of Chemical Biology. 9: 1710-5. PMID 18604835 DOI: 10.1002/Cbic.200800178  0.552
2008 Chiang YM, Szewczyk E, Nayak T, Davidson AD, Sanchez JF, Lo HC, Ho WY, Simityan H, Kuo E, Praseuth A, Watanabe K, Oakley BR, Wang CC. Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway. Chemistry & Biology. 15: 527-32. PMID 18559263 DOI: 10.1016/J.Chembiol.2008.05.010  0.572
2008 Zhou H, Zhan J, Watanabe K, Xie X, Tang Y. A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proceedings of the National Academy of Sciences of the United States of America. 105: 6249-54. PMID 18427109 DOI: 10.1073/Pnas.0800657105  0.62
2008 Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J. Identifying the minimal enzymes required for anhydrotetracycline biosynthesis. Journal of the American Chemical Society. 130: 6068-9. PMID 18422316 DOI: 10.1021/Ja800951E  0.629
2008 Praseuth AP, Praseuth MB, Oguri H, Oikawa H, Watanabe K, Wang CC. Improved production of triostin A in engineered Escherichia coli with furnished quinoxaline chromophore by design of experiments in small-scale culture. Biotechnology Progress. 24: 134-9. PMID 18173279 DOI: 10.1021/Bp070298Y  0.553
2008 Ma SM, Zhan J, Xie X, Watanabe K, Tang Y, Zhang W. Redirecting the cyclization steps of fungal polyketide synthase. Journal of the American Chemical Society. 130: 38-9. PMID 18072779 DOI: 10.1021/Ja078091O  0.513
2007 Ma SM, Zhan J, Watanabe K, Xie X, Zhang W, Wang CC, Tang Y. Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. Journal of the American Chemical Society. 129: 10642-3. PMID 17696354 DOI: 10.1021/Ja074865P  0.603
2007 Zhang W, Watanabe K, Wang CC, Tang Y. Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway. The Journal of Biological Chemistry. 282: 25717-25. PMID 17631493 DOI: 10.1074/Jbc.M703437200  0.686
2007 Zhang W, Wilke BI, Zhan J, Watanabe K, Boddy CN, Tang Y. A new mechanism for benzopyrone formation in aromatic polyketide biosynthesis. Journal of the American Chemical Society. 129: 9304-5. PMID 17625867 DOI: 10.1021/Ja0736919  0.76
2007 Watanabe K, Praseuth AP, Wang CC. A comprehensive and engaging overview of the type III family of polyketide synthases. Current Opinion in Chemical Biology. 11: 279-86. PMID 17482864 DOI: 10.1016/J.Cbpa.2006.11.041  0.594
2007 Koketsu K, Oguri H, Watanabe K, Oikawa H. Identification and stereochemical assignment of the beta-hydroxytryptophan intermediate in the echinomycin biosynthetic pathway. Organic Letters. 8: 4719-22. PMID 17020286 DOI: 10.1021/Ol061738+  0.339
2006 Watanabe K, Oikawa H. Robust platform for de novo production of heterologous polyketides and nonribosomal peptides in Escherichia coli. Organic & Biomolecular Chemistry. 5: 593-602. PMID 17285165 DOI: 10.1039/B615589H  0.444
2006 Zhang W, Watanabe K, Wang CC, Tang Y. Heterologous biosynthesis of amidated polyketides with novel cyclization regioselectivity from oxytetracycline polyketide synthase. Journal of Natural Products. 69: 1633-6. PMID 17125237 DOI: 10.1021/Np060290I  0.667
2006 Xie X, Watanabe K, Wojcicki WA, Wang CC, Tang Y. Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. Chemistry & Biology. 13: 1161-9. PMID 17113998 DOI: 10.1016/J.Chembiol.2006.09.008  0.686
2006 Watanabe K, Hotta K, Praseuth AP, Koketsu K, Migita A, Boddy CN, Wang CC, Oguri H, Oikawa H. Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli. Nature Chemical Biology. 2: 423-8. PMID 16799553 DOI: 10.1038/Nchembio803  0.737
2005 Hung VS, Hatada Y, Goda S, Lu J, Hidaka Y, Li Z, Akita M, Ohta Y, Watanabe K, Matsui H, Ito S, Horikoshi K. alpha-Glucosidase from a strain of deep-sea Geobacillus: a potential enzyme for the biosynthesis of complex carbohydrates. Applied Microbiology and Biotechnology. 68: 757-65. PMID 15940457 DOI: 10.1007/S00253-005-1977-3  0.366
2005 Senoura T, Isono N, Yoshikawa M, Asao A, Hamada S, Watanabe K, Ito H, Matsui H. Characterization of starch synthase I and II expressed in early developing seeds of kidney bean (Phaseolus vulgaris L.). Bioscience, Biotechnology, and Biochemistry. 68: 1949-60. PMID 15388972 DOI: 10.1271/Bbb.68.1949  0.335
2004 Morimoto N, Yasukawa Y, Watanabe K, Unno T, Ito H, Matsui H. Cloning and heterologous expression of a glucodextranase gene from Arthrobacter globiformis I42, and experimental evidence for the catalytic diad of the recombinant enzyme. Journal of Bioscience and Bioengineering. 97: 127-130. PMID 16233603 DOI: 10.1016/S1389-1723(04)70179-6  0.341
2004 Thompson TB, Katayama K, Watanabe K, Hutchinson CR, Rayment I. Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase. The Journal of Biological Chemistry. 279: 37956-63. PMID 15231835 DOI: 10.1074/Jbc.M406144200  0.391
2004 Ose T, Watanabe K, Yao M, Honma M, Oikawa H, Tanaka I. Structure of macrophomate synthase. Acta Crystallographica. Section D, Biological Crystallography. 60: 1187-97. PMID 15213379 DOI: 10.1107/S0907444904008881  0.351
2004 Tochihara T, Sasaki K, Araki O, Morimoto N, Watanabe K, Hatada Y, Ito S, Ito H, Matsui H. Site-directed mutagenesis establishes aspartic acids-227 and -342 as essential for enzyme activity in an isomalto-dextranase from Arthrobacter globiformis Biotechnology Letters. 26: 659-664. PMID 15200177 DOI: 10.1023/B:Bile.0000023026.55433.6A  0.317
2004 Toyomasu T, Nakaminami K, Toshima H, Mie T, Watanabe K, Ito H, Matsui H, Mitsuhashi W, Sassa T, Oikawa H. Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha. Bioscience, Biotechnology, and Biochemistry. 68: 146-52. PMID 14745177 DOI: 10.1271/Bbb.68.146  0.343
2003 Watanabe K, Khosla C, Stroud RM, Tsai SC. Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. Journal of Molecular Biology. 334: 435-44. PMID 14623185 DOI: 10.1016/J.Jmb.2003.10.021  0.558
2003 Watanabe K, Wang CC, Boddy CN, Cane DE, Khosla C. Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. The Journal of Biological Chemistry. 278: 42020-6. PMID 12923197 DOI: 10.1074/Jbc.M305339200  0.757
2003 Watanabe K, Rude MA, Walsh CT, Khosla C. Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 100: 9774-8. PMID 12888623 DOI: 10.1073/Pnas.1632167100  0.804
2003 Ose T, Watanabe K, Mie T, Honma M, Watanabe H, Yao M, Oikawa H, Tanaka I. Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase. Nature. 422: 185-9. PMID 12634789 DOI: 10.1038/Nature01454  0.421
2000 Oikawa H, Yagi K, Ohashi S, Watanabe K, Takashi M, Ichihara A, Honma M, Kobayashi K. Potent inhibition of macrophomate synthase by reaction intermediate analogs. Bioscience, Biotechnology, and Biochemistry. 64: 2368-2379. PMID 11193404 DOI: 10.1271/Bbb.64.2368  0.306
2000 Watanabe K, Mie T, Ichihara A, Oikawa H, Honma M. Detailed reaction mechanism of macrophomate synthase: extraordinary enzyme catalyzing five-step transformation from 2-pyrones to benzoates. Journal of Biological Chemistry. 275: 38393-38401. PMID 10984474 DOI: 10.1074/Jbc.M003119200  0.376
2000 Watanabe K, Mie T, Ichihara A, Oikawa H, Honma M. Substrate diversity of macrophomate synthase catalyzing an unusual multistep transformation from 2-pyrones to benzoates. Bioscience, Biotechnology, and Biochemistry. 64: 530-538. PMID 10803950 DOI: 10.1271/Bbb.64.530  0.366
2000 Watanabe K, Oikawa H, Yagi K, Ohashi S, Mie T, Ichihara A, Honma M. Macrophomate synthase: characterization, sequence, and expression in Escherichia coli of the novel enzyme catalyzing unusual multistep transformation of 2-pyrones to benzoates. Journal of Biochemistry. 127: 467-473. PMID 10731719 DOI: 10.1093/Oxfordjournals.Jbchem.A022629  0.333
2000 Watanabe K, Mie T, Ichihara A, Oikawa H, Honma M. Reaction mechanism of the macrophomate synthase: Experimental evidence on intermediacy of a bicyclic compound. Tetrahedron Letters. 41: 1443-1446. DOI: 10.1016/S0040-4039(99)02311-4  0.363
1999 Oikawa H, Watanabe K, Yagi K, Ohashi S, Mie T, Ichihara A, Honma M. Macrophomate synthase: unusual enzyme catalyzing multiple reactions from pyrones to benzoates Tetrahedron Letters. 40: 6983-6986. DOI: 10.1016/S0040-4039(99)01441-0  0.358
1997 Oikawa H, Yagi K, Watanabe K, Honma M, Ichihara A. Biosynthesis of macrophomic acid: plausible involvement ofintermolecular Diels–Alder reaction Chemical Communications. 97-98. DOI: 10.1039/A607412J  0.33
1987 Tsuboi S, Mimura S, Ono S, Watanabe K, Takeda A. Oxidation of 2,4-Alkadienoic Esters with Selenium Dioxide. A New Synthesis of Furans and Selenophenes Bulletin of the Chemical Society of Japan. 60: 1807-1812. DOI: 10.1246/Bcsj.60.1807  0.322
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