Peter M. Blumberg - Publications

Affiliations: 
NIH (NCI) 

272 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kang JM, Kwon SO, Ann J, Lee S, Kim C, Do N, Jeong JJ, Blumberg PM, Ha H, Vu TNL, Yoon S, Choi S, Frank-Foltyn R, Lesch B, Bahrenberg G, et al. 2-(Halogenated Phenyl) Acetamides and Propanamides as Potent TRPV1 Antagonists. Bioorganic & Medicinal Chemistry Letters. 128266. PMID 34273488 DOI: 10.1016/j.bmcl.2021.128266  1
2021 Thorat SA, Lee Y, Jung A, Ann J, Ahn S, Baek J, Zuo D, Do N, Jeong JJ, Blumberg PM, Esch TE, Turcios NA, Pearce LV, Ha HJ, Yoo YD, et al. Discovery of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists and Antagonists and the Structural Elucidation of Their Activity Shift. Journal of Medicinal Chemistry. PMID 33385210 DOI: 10.1021/acs.jmedchem.0c00982  1
2020 Mi Kang J, Ok Kwon S, Ann J, Blumberg PM, Ha H, Dong Yoo Y, Frank-Foltyn R, Lesch B, Bahrenberg G, Stockhausen H, Christoph T, Lee J. Discovery of 1-(1H-Indazol-4-yl)-3-((1-Phenyl-1H-Pyrazol-5-yl)methyl) Ureas as Potent and Thermoneutral TRPV1 Antagonists. Bioorganic & Medicinal Chemistry Letters. 127548. PMID 32931910 DOI: 10.1016/j.bmcl.2020.127548  1
2019 Ahn S, Kim YS, Kim MS, Ann J, Ha H, Yoo YD, Kim YH, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, Lee J. Discovery of indane propanamides as potent and selective TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 126838. PMID 31864799 DOI: 10.1016/J.Bmcl.2019.126838  1
2019 Ann J, Kim HS, Thorat SA, Kim H, Ha H, Choi K, Kim YH, Kim M, Hwang SW, Pearce LV, Esch TE, Turcios NA, Blumberg PM, Lee J. Discovery of Non-pungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic. Journal of Medicinal Chemistry. PMID 31702924 DOI: 10.1021/Acs.Jmedchem.9B01046  1
2019 Lee H, Ahn S, Ann J, Ha H, Yoo YD, Kim YH, Hwang JY, Hur KH, Jang CG, Pearce LV, Esch TE, Lewin NE, Blumberg PM, Lee J. Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain. European Journal of Medicinal Chemistry. 182: 111634. PMID 31472474 DOI: 10.1016/J.Ejmech.2019.111634  1
2019 Pearce LV, Ann J, Blumberg PM, Lee J. Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level. Biomolecules & Therapeutics. PMID 31302951 DOI: 10.4062/Biomolther.2019.013  1
2019 Blanco FA, Czikora A, Kedei N, You Y, Mitchell GA, Pany S, Ghosh A, Blumberg PM, Das J. Munc13 Is a Molecular Target of Bryostatin 1. Biochemistry. PMID 31243993 DOI: 10.1021/Acs.Biochem.9B00427  1
2019 Cooke M, Casado-Medrano V, Ann J, Lee J, Blumberg PM, Abba MC, Kazanietz MG. Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes. Scientific Reports. 9: 6041. PMID 30988374 DOI: 10.1038/S41598-019-42581-4  1
2018 Kim C, Ann J, Lee S, Kim E, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, Lee J. 4-Aminophenyl acetamides and propanamides as potent transient receptor potential vanilloid 1 (TRPV1) ligands. Bioorganic & Medicinal Chemistry. PMID 30078610 DOI: 10.1016/J.Bmc.2018.07.040  1
2018 Kim C, Ann J, Lee S, Sun W, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, Lee J. Discovery of 2-(3,5-difluoro-4-methylsulfonaminophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 29884534 DOI: 10.1016/J.Bmcl.2018.05.043  1
2018 Ann J, Czikora A, Saini A, Zhou X, Mitchell GA, Lewin NE, Peach ML, Blumberg PM, Lee J. α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine Releasing Protein 3 (RasGRP3) Ligands. Journal of Medicinal Chemistry. PMID 29860841 DOI: 10.1021/Acs.Jmedchem.8B00661  1
2018 Cooke M, Zhou X, Casado-Medrano V, Lopez-Haber C, Baker MJ, Garg R, Ann J, Lee J, Blumberg PM, Kazanietz MG. Characterization of AJH-836, a DAG-lactone with selectivity for novel PKC isozymes. The Journal of Biological Chemistry. PMID 29636415 DOI: 10.1074/Jbc.Ra117.000235  1
2018 Zhao X, Kedei N, Michalowski AM, Lewin NE, Keck GE, Blumberg PM. Deletion of the C-26 Methyl Substituent from the Bryostatin Analogue Merle 23 has Negligible Impact on Its Biological Profile or Potency. Chembiochem : a European Journal of Chemical Biology. PMID 29517836 DOI: 10.1002/Cbic.201700677  1
2018 Cummins TJ, Kedei N, Czikora A, Lewin NE, Kirk S, Petersen ME, McGowan KM, Chen JQ, Luo X, Johnson RC, Ravichandran S, Blumberg PM, Keck GE. Synthesis and Biological Evaluation of Fluorescent Bryostatin Analogues. Chembiochem : a European Journal of Chemical Biology. PMID 29424951 DOI: 10.1002/Cbic.201700655  1
2018 Czikora A, Pany S, You Y, Saini AS, Lewin NE, Mitchell GA, Abramovitz A, Kedei N, Blumberg PM, Das J. Structural determinants of phorbol ester binding activity of the C1a and C1b domains of protein kinase C theta. Biochimica Et Biophysica Acta. PMID 29317197 DOI: 10.1016/J.Bbamem.2018.01.007  1
2017 Das J, Kedei N, Kelsey JS, You Y, Pany S, Mitchell GA, Lewin NE, Blumberg PM. Critical role of Trp-588 of presynaptic Munc13-1 for ligand binding and membrane translocation. Biochemistry. PMID 29244485 DOI: 10.1021/Acs.Biochem.7B00764  1
2017 Kelsey JS, Géczy T, Kaler CJ, Blumberg PM. The C1 domain of Vav3, a novel potential therapeutic target. Cellular Signalling. 40: 133-142. PMID 28927664 DOI: 10.1016/J.Cellsig.2017.09.008  1
2017 Czikora A, Kedei N, Kalish H, Blumberg PM. Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3. Biochimica Et Biophysica Acta. 1859: 2350-2360. PMID 28912101 DOI: 10.1016/J.Bbamem.2017.09.010  1
2017 Pearce LV, Ann J, Jung A, Thorat SA, Herold BKA, Habtemichael AD, Blumberg PM, Lee J. Novel Radiolabeled Vanilloid with Enhanced Specificity for Human Transient Receptor Potential Vanilloid 1 (TRPV1). Journal of Medicinal Chemistry. PMID 28892388 DOI: 10.1021/Acs.Jmedchem.7B00859  1
2017 Lee S, Kim C, Ann J, Thorat SA, Kim E, Park J, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, Lee J. Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 28838698 DOI: 10.1016/J.Bmcl.2017.08.020  1
2017 Ohashi N, Kobayashi R, Nomura W, Kobayakawa T, Czikora A, Herold B, Lewin N, Blumberg PM, Tamamura H. Synthesis and evaluation of dimeric derivatives of diacylglycerol-lactones as PKC ligands. Bioconjugate Chemistry. PMID 28671468 DOI: 10.1021/Acs.Bioconjchem.7B00299  1
2017 Elhalem E, Donadío LG, Zhou X, Lewin NE, Garcia LC, Lai CC, Kelley JA, Peach ML, Blumberg PM, Comin MJ. Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP. Bioorganic & Medicinal Chemistry. PMID 28392275 DOI: 10.1016/J.Bmc.2017.03.022  1
2017 Lee S, Kang DW, Ryu H, Kim C, Ann J, Lee H, Kim E, Hong S, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, Lee J. t-Butyl pyridine and phenyl C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry. PMID 28314510 DOI: 10.1016/J.Bmc.2017.03.004  1
2017 Abramovitz A, Kedei N, Blumberg PM. Abstract 5344: Understanding the structural requirements of C1 domains for phorbol ester binding, analysis of the atypical C1 domain of STAC2 Cancer Research. 77: 5344-5344. DOI: 10.1158/1538-7445.Am2017-5344  1
2017 Czikora A, Pany S, You Y, Saini A, Kedei N, Lewin NE, Abramovitz A, Das J, Blumberg PM. Abstract 2373: Analysis of the distinct activities of the C1a and C1b domains of protein kinase C theta Cancer Research. 77: 2373-2373. DOI: 10.1158/1538-7445.Am2017-2373  1
2017 Kedei N, Das S, Andresson T, Blumberg PM. Abstract 215: Characterization by mass spectrometry of protein kinase C substrates differentially phosphorylated in LNCaP cells in response to phorbol ester and bryostatin 1 treatment Cancer Research. 77: 215-215. DOI: 10.1158/1538-7445.Am2017-215  1
2016 Petersen ME, Kedei N, Lewin NE, Blumberg PM, Keck GE. Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC. Tetrahedron Letters. 57: 4749-4753. PMID 27713589 DOI: 10.1016/J.Tetlet.2016.09.040  1
2016 Ketcham JM, Volchkov I, Chen TY, Blumberg PM, Kedei N, Lewin NE, Krische MJ. Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology. Journal of the American Chemical Society. PMID 27676096 DOI: 10.1021/Jacs.6B08695  1
2016 Baumann DO, McGowan KM, Kedei N, Peach ML, Blumberg PM, Keck GE. Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-ring. The Journal of Organic Chemistry. PMID 27494208 DOI: 10.1021/Acs.Joc.6B01516  1
2016 Ann J, Sun W, Zhou X, Jung A, Baek J, Lee S, Kim C, Yoon S, Hong S, Choi S, Turcios NA, Herold BK, Esch TE, Lewin NE, Abramovitz A, ... ... Blumberg PM, et al. Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template. Bioorganic & Medicinal Chemistry Letters. PMID 27317643 DOI: 10.1016/J.Bmcl.2016.06.010  1
2016 Zhang F, Hanson SM, Jara-Oseguera A, Krepkiy D, Bae C, Pearce LV, Blumberg PM, Newstead S, Swartz KJ. Engineering vanilloid-sensitivity into the rat TRPV2 channel. Elife. 5. PMID 27177419 DOI: 10.7554/Elife.16409  1
2016 Czikora A, Lundberg DJ, Abramovitz A, Lewin NE, Kedei N, Peach ML, Zhou X, Merritt RC, Craft EA, Braun DC, Blumberg PM. Structural basis for the failure of the C1 domain of RasGRP2 to bind phorbol ester with high affinity. The Journal of Biological Chemistry. PMID 27022025 DOI: 10.1074/Jbc.M116.725333  1
2016 Feng Z, Pearce LV, Zhang Y, Xing C, Herold BK, Ma S, Hu Z, Turcios NA, Yang P, Tong Q, McCall AK, Blumberg PM, Xie XQ. Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation. The Aaps Journal. PMID 27000851 DOI: 10.1208/S12248-016-9888-Z  1
2016 Ann J, Ki Y, Yoon S, Kim MS, Lee JU, Kim C, Lee S, Jung A, Baek J, Hong S, Choi S, Pearce LV, Esch TE, Turcios NA, Lewin NE, ... ... Blumberg PM, et al. 2-Sulfonamidopyridine C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry. PMID 26860926 DOI: 10.1016/J.Bmc.2016.01.051  1
2016 Kelsey JS, Cataisson C, Chen J, Herrmann MA, Petersen ME, Baumann DA, McGowan KM, Yuspa SH, Keck GE, Blumberg PM. Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin. Molecular Carcinogenesis. PMID 26859836 DOI: 10.1002/Mc.22460  1
2016 Zhang F, Hanson SM, Jara-Oseguera A, Krepkiy D, Bae C, Pearce LV, Blumberg PM, Newstead S, Swartz KJ. Author response: Engineering vanilloid-sensitivity into the rat TRPV2 channel Elife. DOI: 10.7554/Elife.16409.015  1
2016 Kedei N, Paine EL, Jenkins LMM, Blumberg PM. Abstract 4423: Methylation and acetylation are novel post-translational modifications identified for the pre-apoptotic protein kinase C (PKC) delta Cancer Research. 76: 4423-4423. DOI: 10.1158/1538-7445.Am2016-4423  1
2016 Chen J, Kedei N, Goldstein DJ, Malik MQ, Blumberg PM. Abstract 3889: An aptamer-based multiplexed proteomic technology reveals differential PKC ligand responses Cancer Research. 76: 3889-3889. DOI: 10.1158/1538-7445.Am2016-3889  1
2016 Czikora A, Kedei N, Blumberg PM. Abstract 1126: Importance of the REM (Ras exchange) motif for membrane interactions by RasGRP3 Cancer Research. 76: 1126-1126. DOI: 10.1158/1538-7445.Am2016-1126  1
2015 Blumberg PM. To not be hot when TRPV1 is not. Temperature (Austin, Tex.). 2: 166-7. PMID 27227019 DOI: 10.1080/23328940.2015.1048045  0.01
2015 Ann J, Jung A, Kim MY, Kim HM, Ryu H, Kim S, Kang DW, Hong S, Cui M, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, et al. Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry. PMID 26474664 DOI: 10.1016/J.Bmc.2015.10.001  1
2015 Tran PT, Kim HS, Ann J, Kim SE, Kim C, Hong M, Hoang VH, Ngo VT, Hong S, Cui M, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, et al. α-Substituted 2-(3-fluoro-4-methylsulfonamidophenyl)acetamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 25: 2326-30. PMID 25937016 DOI: 10.1016/J.Bmcl.2015.04.024  1
2015 Kedei N, Kraft MB, Keck GE, Herald CL, Melody N, Pettit GR, Blumberg PM. Neristatin 1 provides critical insight into bryostatin 1 structure-function relationships. Journal of Natural Products. 78: 896-900. PMID 25808573 DOI: 10.1021/Acs.Jnatprod.5B00094  1
2015 Lee HK, Finniss S, Cazacu S, Xiang C, Poisson LM, Blumberg PM, Brodie C. RasGRP3 regulates the migration of glioma cells via interaction with Arp3. Oncotarget. 6: 1850-64. PMID 25682201 DOI: 10.18632/Oncotarget.2575  1
2015 Ryu H, Seo S, Lee JY, Ha TH, Lee S, Jung A, Ann J, Kim SE, Yoon S, Hong M, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Schiene K, Stockhausen H, et al. Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists. European Journal of Medicinal Chemistry. 93: 101-8. PMID 25659771 DOI: 10.1016/J.Ejmech.2015.02.001  1
2015 Feng Z, Pearce LV, Xu X, Yang X, Yang P, Blumberg PM, Xie XQ. Structural insight into tetrameric hTRPV1 from homology modeling, molecular docking, molecular dynamics simulation, virtual screening, and bioassay validations. Journal of Chemical Information and Modeling. 55: 572-88. PMID 25642729 DOI: 10.1021/Ci5007189  1
2015 Sun W, Kim HS, Lee S, Jung A, Kim SE, Ann J, Yoon S, Choi S, Lee JH, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Schiene K, Stockhausen H, Christoph T, et al. 6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 25: 803-6. PMID 25597011 DOI: 10.1016/J.Bmcl.2014.12.086  1
2015 Ann J, Yoon S, Baek J, Kim da H, Lewin NE, Hill CS, Blumberg PM, Lee J. Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones). European Journal of Medicinal Chemistry. 90: 332-41. PMID 25437619 DOI: 10.1016/J.Ejmech.2014.11.025  1
2015 Czifra G, Szöll?si A, Nagy Z, Boros M, Juhász I, Kiss A, Erd?di F, Szabó T, Kovács I, Török M, Kovács L, Blumberg PM, Bíró T. Protein kinase Cδ promotes proliferation and induces malignant transformation in skeletal muscle. Journal of Cellular and Molecular Medicine. 19: 396-407. PMID 25283340 DOI: 10.1111/Jcmm.12452  1
2015 Kedei N, Chen J, Herrmann M, Hu T, Chang K, Blumberg PM. Abstract 4977: Dramatic differences in the extents and patterns of PKC delta modification among the different members of the NCI-60 cancer cell line panel Cancer Research. 75: 4977-4977. DOI: 10.1158/1538-7445.Am2015-4977  1
2015 Czikora A, Lundberg DJ, Lewin NE, Kedei N, Blumberg PM. Abstract 3928: Structural basis for the failure of the C1 domain of RasGRP2 to bind phorbol ester Cancer Research. 75: 3928-3928. DOI: 10.1158/1538-7445.Am2015-3928  1
2014 Andrews IP, Ketcham JM, Blumberg PM, Kedei N, Lewin NE, Peach ML, Krische MJ. Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties. Journal of the American Chemical Society. 136: 13209-16. PMID 25207655 DOI: 10.1021/Ja507825S  1
2014 Kraft MB, Poudel YB, Kedei N, Lewin NE, Peach ML, Blumberg PM, Keck GE. Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone core. Journal of the American Chemical Society. 136: 13202-8. PMID 25207434 DOI: 10.1021/Ja5078188  1
2014 Ryu H, Seo S, Kim MS, Kim MY, Kim HS, Ann J, Tran PT, Hoang VH, Byun J, Cui M, Son K, Sharma PK, Choi S, Blumberg PM, Frank-Foltyn R, et al. 2-Aryl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 24: 4044-7. PMID 25011915 DOI: 10.1016/J.Bmcl.2014.05.072  1
2014 Ryu H, Seo S, Cho SH, Kim HS, Jung A, Kang DW, Son K, Cui M, Hong SH, Sharma PK, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, et al. 2-Alkyl/alkenyl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 24: 4039-43. PMID 24948568 DOI: 10.1016/j.bmcl.2014.05.074  1
2014 Kedei N, Chen JQ, Herrmann MA, Telek A, Goldsmith PK, Petersen ME, Keck GE, Blumberg PM. Molecular systems pharmacology: isoelectric focusing signature of protein kinase Cδ provides an integrated measure of its modulation in response to ligands. Journal of Medicinal Chemistry. 57: 5356-69. PMID 24906106 DOI: 10.1021/Jm500417B  1
2014 Garcia LC, Donadío LG, Mann E, Kolusheva S, Kedei N, Lewin NE, Hill CS, Kelsey JS, Yang J, Esch TE, Santos M, Peach ML, Kelley JA, Blumberg PM, Jelinek R, et al. Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP. Bioorganic & Medicinal Chemistry. 22: 3123-40. PMID 24794745 DOI: 10.1016/J.Bmc.2014.04.024  1
2014 Kim HS, Jin MK, Kang SU, Lim JO, Tran PT, Hoang VH, Ann J, Ha TH, Pearce LV, Pavlyukovets VA, Blumberg PM, Lee J. α-Methylated simplified resiniferatoxin (sRTX) thiourea analogues as potent and stereospecific TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 24: 2685-8. PMID 24794110 DOI: 10.1016/J.Bmcl.2014.04.054  1
2014 Nagy Z, Kovács I, Török M, Tóth D, Vereb G, Buzás K, Juhász I, Blumberg PM, Bíró T, Czifra G. Function of RasGRP3 in the formation and progression of human breast cancer. Molecular Cancer. 13: 96. PMID 24779681 DOI: 10.1186/1476-4598-13-96  1
2014 Kelsey JS, Geczy T, Lewin NE, Kedei N, Hill CS, Selezneva JS, Valle CJ, Woo W, Gorshkova I, Blumberg PM. Charge density influences C1 domain ligand affinity and membrane interactions. Chembiochem : a European Journal of Chemical Biology. 15: 1131-44. PMID 24777910 DOI: 10.1002/Cbic.201400041  1
2014 Pu Y, Kang JH, Sigano DM, Peach ML, Lewin NE, Marquez VE, Blumberg PM. Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains. Journal of Medicinal Chemistry. 57: 3835-44. PMID 24684293 DOI: 10.1021/Jm500165N  1
2014 Kim MS, Ki Y, Ahn SY, Yoon S, Kim SE, Park HG, Sun W, Son K, Cui M, Choi S, Pearce LV, Esch TE, Deandrea-Lazarus IA, Blumberg PM, Lee J. Asymmetric synthesis and receptor activity of chiral simplified resiniferatoxin (sRTX) analogues as transient receptor potential vanilloid 1 (TRPV1) ligands. Bioorganic & Medicinal Chemistry Letters. 24: 382-5. PMID 24321344 DOI: 10.1016/J.Bmcl.2013.10.064  1
2014 Chen J, Kedei N, Herrmann MA, Blumberg PM. Abstract 5315: Quantitative proteomic assessment of differential ligand responses downstream of protein kinase C activation Cancer Research. 74: 5315-5315. DOI: 10.1158/1538-7445.Am2014-5315  1
2014 Czikora A, Kedei N, Blumberg PM. Abstract 4450: Comparison of structural elements in RasGRP3 and RasGRP1 controlling membrane interaction Cancer Research. 74: 4450-4450. DOI: 10.1158/1538-7445.Am2014-4450  1
2014 Kedei N, Michalowski AM, Blumberg PM. Abstract 3195: Transient duration of action is the primary mechanism responsible for the unique biology of bryostatin 1 Cancer Research. 74: 3195-3195. DOI: 10.1158/1538-7445.Am2014-3195  1
2014 Kelsey J, Kedei N, Cataisson C, Petersen M, Yuspa S, Keck G, Blumberg P. Abstract 1642: Bryostatin 1 and the simplified analog Merle 23 have similar and opposing properties on mouse epidermal cells and mouse skin Cancer Research. 74: 1642-1642. DOI: 10.1158/1538-7445.Am2014-1642  1
2013 Ha TH, Ryu H, Kim SE, Kim HS, Ann J, Tran PT, Hoang VH, Son K, Cui M, Choi S, Blumberg PM, Frank R, Bahrenberg G, Schiene K, Christoph T, et al. TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides. Bioorganic & Medicinal Chemistry. 21: 6657-64. PMID 24035514 DOI: 10.1016/J.Bmc.2013.08.015  1
2013 Song X, Lopez-Campistrous A, Sun L, Dower NA, Kedei N, Yang J, Kelsey JS, Lewin NE, Esch TE, Blumberg PM, Stone JC. RasGRPs are targets of the anti-cancer agent ingenol-3-angelate. Plos One. 8: e72331. PMID 23991094 DOI: 10.1371/Journal.Pone.0072331  1
2013 Lim KS, Lee H, Kim SE, Ha TH, Ann J, Son K, Choi S, Sun W, Pearce LV, DeAndrea-Lazarus IA, Blumberg PM, Lee J. The carbonate analogues of 5'-halogenated resiniferatoxin as TRPV1 ligands. European Journal of Medicinal Chemistry. 68: 233-43. PMID 23981530 DOI: 10.1016/J.Ejmech.2013.07.042  1
2013 Chen JQ, Heldman MR, Herrmann MA, Kedei N, Woo W, Blumberg PM, Goldsmith PK. Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system. Analytical Biochemistry. 442: 97-103. PMID 23896461 DOI: 10.1016/J.Ab.2013.07.022  1
2013 Thorat SA, Kang DW, Ryu H, Kim MS, Kim HS, Ann J, Ha T, Kim SE, Son K, Choi S, Blumberg PM, Frank R, Bahrenberg G, Schiene K, Christoph T, et al. 2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: structure activity relationships of the 2-oxy pyridine C-region. European Journal of Medicinal Chemistry. 64: 589-602. PMID 23685943 DOI: 10.1016/J.Ejmech.2013.04.003  1
2013 van Veghel D, Cleynhens J, Pearce LV, DeAndrea-Lazarus IA, Blumberg PM, Van Laere K, Verbruggen A, Bormans G. New transient receptor potential vanilloid subfamily member 1 positron emission tomography radioligands: synthesis, radiolabeling, and preclinical evaluation. Acs Chemical Neuroscience. 4: 624-34. PMID 23421633 DOI: 10.1021/Cn300233V  1
2013 Kedei N, Lewin NE, Géczy T, Selezneva J, Braun DC, Chen J, Herrmann MA, Heldman MR, Lim L, Mannan P, Garfield SH, Poudel YB, Cummins TJ, Rudra A, Blumberg PM, et al. Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1. Acs Chemical Biology. 8: 767-77. PMID 23369356 DOI: 10.1021/Cb300671S  1
2013 Rahman GM, Shanker S, Lewin NE, Kedei N, Hill CS, Prasad BV, Blumberg PM, Das J. Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ). The Biochemical Journal. 451: 33-44. PMID 23289588 DOI: 10.1042/Bj20121307  1
2013 Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL. A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice. Journal of Immunology (Baltimore, Md. : 1950). 190: 147-58. PMID 23209318 DOI: 10.4049/Jimmunol.1201458  1
2013 Kedei N, Telek A, Michalowski AM, Kraft MB, Li W, Poudel YB, Rudra A, Petersen ME, Keck GE, Blumberg PM. Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action. Biochemical Pharmacology. 85: 313-24. PMID 23146662 DOI: 10.1016/J.Bcp.2012.10.028  1
2013 van Veghel D, Cleynhens J, Pearce LV, Blumberg PM, Van Laere K, Verbruggen A, Bormans G. Synthesis and biological evaluation of [¹¹C]SB366791: a new PET-radioligand for in vivo imaging of the TRPV1 receptor. Nuclear Medicine and Biology. 40: 141-7. PMID 23141549 DOI: 10.1016/J.Nucmedbio.2012.08.011  1
2013 Nagy Z, Orosz E, Kovács I, Török M, Tóth D, Bíró T, Blumberg PM, Czifra G. Abstract 4399: Investigation of RasGRP3 expression and function in human breast cancers and breast-derived ductal adenocarcinoma cell lines. Cancer Research. 73: 4399-4399. DOI: 10.1158/1538-7445.Am2013-4399  1
2013 Yang J, Esch T, Yang D, Blumberg P. Abstract 4292: RasGRP3 contributes to Ras signaling, growth, and migration of human lung cancer cell lines. Cancer Research. 73: 4292-4292. DOI: 10.1158/1538-7445.Am2013-4292  1
2013 Kelsey J, Kedei N, Cataisson C, Petersen M, Yuspa S, Keck G, Blumberg P. Abstract 2454: Comparison of the activity of the bryostatin derivative Merle 23 with that of bryostatin 1 and phorbol ester in mouse epidermal cells. Cancer Research. 73: 2454-2454. DOI: 10.1158/1538-7445.Am2013-2454  1
2013 Kedei N, Michalowski AM, Petersen ME, Keck GE, Blumberg PM. Abstract 2101: Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogue in LNCaP and U937 cells provides insight into their differential mechanism. Cancer Research. 73: 2101-2101. DOI: 10.1158/1538-7445.Am2013-2101  1
2012 Heldman M, Herrmann M, Kedei N, Blumberg P, Goldsmith P. A fully automated capillary western system for absolute quantitation of endogenous PKC proteins: An approach to correlate protein quantity with function. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 31. PMID 28142421 DOI: 10.1200/Jco.2012.30.30_Suppl.31  1
2012 Kim MS, Ryu H, Kang DW, Cho SH, Seo S, Park YS, Kim MY, Kwak EJ, Kim YS, Bhondwe RS, Kim HS, Park SG, Son K, Choi S, DeAndrea-Lazarus IA, ... ... Blumberg PM, et al. 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: structure-activity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3-ylmethyl) C-region. Journal of Medicinal Chemistry. 55: 8392-408. PMID 22957803 DOI: 10.1021/Jm300780P  1
2012 Cho Y, Kim MS, Kim HS, Ann J, Lee J, Pearce LV, Pavlyukovets VA, Morgan MA, Blumberg PM, Lee J. The SAR analysis of TRPV1 agonists with the α-methylated B-region. Bioorganic & Medicinal Chemistry Letters. 22: 5227-31. PMID 22796184 DOI: 10.1016/J.Bmcl.2012.06.059  1
2012 Keck GE, Poudel YB, Rudra A, Stephens JC, Kedei N, Lewin NE, Blumberg PM. Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity. Bioorganic & Medicinal Chemistry Letters. 22: 4084-8. PMID 22579485 DOI: 10.1016/J.Bmcl.2012.04.073  1
2012 Bhondwe RS, Kang DW, Kim MS, Kim HS, Park SG, Son K, Choi S, Kuhs KA, Pavlyukovets VA, Pearce LV, Blumberg PM, Lee J. Structure-activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl] thiourea template for TRPV1 antagonism. Bioorganic & Medicinal Chemistry Letters. 22: 3656-60. PMID 22546668 DOI: 10.1016/J.Bmcl.2012.04.034  1
2012 Geczy T, Peach ML, El Kazzouli S, Sigano DM, Kang JH, Valle CJ, Selezneva J, Woo W, Kedei N, Lewin NE, Garfield SH, Lim L, Mannan P, Marquez VE, Blumberg PM. Molecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester. The Journal of Biological Chemistry. 287: 13137-58. PMID 22351766 DOI: 10.1074/Jbc.M111.320010  1
2012 Sun W, Liu K, Ryu H, Kang DW, Kim YS, Kim MS, Cho Y, Bhondwe RS, Thorat SA, Kim HS, Pearce LV, Pavlyukovets VA, Tran R, Morgan MA, Lazar J, ... ... Blumberg PM, et al. 2-(4-Methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the B and C-regions. Bioorganic & Medicinal Chemistry. 20: 1310-8. PMID 22227463 DOI: 10.1016/J.Bmc.2011.12.014  1
2012 Kim YS, Kil MJ, Kang SU, Ryu H, Kim MS, Cho Y, Bhondwe RS, Thorat SA, Sun W, Liu K, Lee JH, Choi S, Pearce LV, Pavlyukovets VA, Morgan MA, ... ... Blumberg PM, et al. N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the A-region. Bioorganic & Medicinal Chemistry. 20: 215-24. PMID 22169633 DOI: 10.1016/J.Bmc.2011.11.008  1
2012 Kedei N, Telek A, Michalowski AM, Kraft MB, Li W, Poudel YB, Rudra A, Petersen ME, Keck GE, Blumberg PM. Abstract 3815: Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogues in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action Cancer Research. 72: 3815-3815. DOI: 10.1158/1538-7445.Am2012-3815  1
2011 Gal N, Kolusheva S, Kedei N, Telek A, Naeem TA, Lewin NE, Lim L, Mannan P, Garfield SH, El Kazzouli S, Sigano DM, Marquez VE, Blumberg PM, Jelinek R. N-methyl-substituted fluorescent DAG-indololactone isomers exhibit dramatic differences in membrane interactions and biological activity. Chembiochem : a European Journal of Chemical Biology. 12: 2331-40. PMID 23106081 DOI: 10.1002/Cbic.201100246  1
2011 Nomura W, Narumi T, Ohashi N, Serizawa Y, Lewin NE, Blumberg PM, Furuta T, Tamamura H. Synthetic caged DAG-lactones for photochemically controlled activation of protein kinase C. Chembiochem : a European Journal of Chemical Biology. 12: 535-9. PMID 22238145 DOI: 10.1002/Cbic.201000670  1
2011 Blumberg PM, Pearce LV, Lee J. TRPV1 activation is not an all-or-none event: TRPV1 partial agonism/antagonism and its regulatory modulation. Current Topics in Medicinal Chemistry. 11: 2151-8. PMID 21671879 DOI: 10.2174/156802611796904825  1
2011 Yang D, Tao J, Li L, Kedei N, Tóth ZE, Czap A, Velasquez JF, Mihova D, Michalowski AM, Yuspa SH, Blumberg PM. RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma. Oncogene. 30: 4590-600. PMID 21602881 DOI: 10.1038/Onc.2011.166  1
2011 Kedei N, Lubart E, Lewin NE, Telek A, Lim L, Mannan P, Garfield SH, Kraft MB, Keck GE, Kolusheva S, Jelinek R, Blumberg PM. Some phorbol esters might partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cells. Chembiochem : a European Journal of Chemical Biology. 12: 1242-51. PMID 21542090 DOI: 10.1002/Cbic.201100064  1
2011 Kedei N, Telek A, Czap A, Lubart ES, Czifra G, Yang D, Chen J, Morrison T, Goldsmith PK, Lim L, Mannan P, Garfield SH, Kraft MB, Li W, Keck GE, ... Blumberg PM, et al. The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line. Biochemical Pharmacology. 81: 1296-308. PMID 21458422 DOI: 10.1016/J.Bcp.2011.03.018  1
2011 Lee JH, Lee Y, Ryu H, Kang DW, Lee J, Lazar J, Pearce LV, Pavlyukovets VA, Blumberg PM, Choi S. Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies. Journal of Computer-Aided Molecular Design. 25: 317-27. PMID 21448716 DOI: 10.1007/S10822-011-9421-5  1
2011 Ohashi N, Nomura W, Narumi T, Lewin NE, Itotani K, Blumberg PM, Tamamura H. Fluorescent-responsive synthetic C1b domains of protein kinase Cδ as reporters of specific high-affinity ligand binding. Bioconjugate Chemistry. 22: 82-7. PMID 21175182 DOI: 10.1021/Bc100414A  1
2011 Lim KS, Kang DW, Kim YS, Kim MS, Park SG, Choi S, Pearce LV, Blumberg PM, Lee J. Receptor activity and conformational analysis of 5'-halogenated resiniferatoxin analogs as TRPV1 ligands. Bioorganic & Medicinal Chemistry Letters. 21: 299-302. PMID 21111618 DOI: 10.1016/J.Bmcl.2010.11.012  1
2011 Kedei N, Telek A, Lubart ES, Lewin NE, Yang D, Chen J, Herrmann MA, Goldsmith PK, Lim L, Mannam P, Garfield SH, Blumberg PM. Abstract 4058: Diverse patterns of biological response to phorbol esters and related protein kinaseC activators in LNCaP human prostate cancer cells Cancer Research. 71: 4058-4058. DOI: 10.1158/1538-7445.Am2011-4058  1
2011 Geczy T, Valle CJ, Selezneva JS, Kedei N, Lewin NE, Lim L, Mannam P, Garfield SH, Peach ML, Blumberg PM. Abstract 3854: Identification of crucial residues at the rim of the binding cleft of the C1 domain of Vav1 that determine its ligand sensitivity Cancer Research. 71: 3854-3854. DOI: 10.1158/1538-7445.Am2011-3854  1
2010 Kang DW, Kim YS, Lim KS, Kim MS, Pearce LV, Pavlyukovets VA, Tao AK, Lang-Kuhs KA, Blumberg PM, Lee J. Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin. Bioorganic & Medicinal Chemistry. 18: 8092-105. PMID 20937561 DOI: 10.1016/J.Bmc.2010.09.001  1
2010 Yang D, Kedei N, Li L, Tao J, Velasquez JF, Michalowski AM, Tóth BI, Marincsák R, Varga A, Bíró T, Yuspa SH, Blumberg PM. RasGRP3 contributes to formation and maintenance of the prostate cancer phenotype. Cancer Research. 70: 7905-17. PMID 20876802 DOI: 10.1158/0008-5472.Can-09-4729  1
2010 Raifman O, Kolusheva S, El Kazzouli S, Sigano DM, Kedei N, Lewin NE, Lopez-Nicolas R, Ortiz-Espin A, Gomez-Fernandez JC, Blumberg PM, Marquez VE, Corbalan-Garcia S, Jelinek R. Membrane-surface anchoring of charged diacylglycerol-lactones correlates with biological activities. Chembiochem : a European Journal of Chemical Biology. 11: 2003-9. PMID 20715268 DOI: 10.1002/Cbic.201000343  1
2010 Keck GE, Poudel YB, Rudra A, Stephens JC, Kedei N, Lewin NE, Peach ML, Blumberg PM. Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1. Angewandte Chemie (International Ed. in English). 49: 4580-4. PMID 20491108 DOI: 10.1002/Anie.201001200  1
2010 Kang JH, Kim Y, Won SH, Park SK, Lee CW, Kim HM, Lewin NE, Perry NA, Pearce LV, Lundberg DJ, Surawski RJ, Blumberg PM, Lee J. Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents. Bioorganic & Medicinal Chemistry Letters. 20: 1008-12. PMID 20045644 DOI: 10.1016/J.Bmcl.2009.12.058  1
2010 Raifman O, Kolusheva S, Comin MJ, Kedei N, Lewin NE, Blumberg PM, Marquez VE, Jelinek R. Membrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities. The Febs Journal. 277: 233-43. PMID 19961537 DOI: 10.1111/J.1742-4658.2009.07477.X  1
2010 Yang D, Juan T, Kedei N, Li L, Yuspa S, Blumberg P. Abstract 5029: RasGRP3- a new therapeutic target in human melanoma Cancer Research. 70: 5029-5029. DOI: 10.1158/1538-7445.Am10-5029  1
2010 Kedei N, Telek A, Czifra G, Czap A, Chen J, Goldsmith PK, Keck GE, Blumberg PM. Abstract 4500: What distinguishes a PKC activator like phorbol ester from a PKC functional antagonist like bryostatin 1? Bryologues permit mechanistic insight Cancer Research. 70: 4500-4500. DOI: 10.1158/1538-7445.Am10-4500  1
2009 Lázár J, Gharat L, Khairathkar-Joshi N, Blumberg PM, Szallasi A. Screening TRPV1 antagonists for the treatment of pain: lessons learned over a decade. Expert Opinion On Drug Discovery. 4: 159-80. PMID 23480514 DOI: 10.1517/17460440802681300  1
2009 Ohashi N, Nomura W, Kato M, Narumi T, Lewin NE, Blumberg PM, Tamamura H. Synthesis of protein kinase Cdelta C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding. Journal of Peptide Science : An Official Publication of the European Peptide Society. 15: 642-6. PMID 19672879 DOI: 10.1002/Psc.1161  1
2009 Tóth A, Blumberg PM, Boczán J. Anandamide and the vanilloid receptor (TRPV1). Vitamins and Hormones. 81: 389-419. PMID 19647120 DOI: 10.1016/S0083-6729(09)81015-7  1
2009 Sosa MS, Lewin NE, Choi SH, Blumberg PM, Kazanietz MG. Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains. Biochemistry. 48: 8171-8. PMID 19618918 DOI: 10.1021/Bi9010623  1
2009 Keck GE, Li W, Kraft MB, Kedei N, Lewin NE, Blumberg PM. The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses. Organic Letters. 11: 2277-80. PMID 19419164 DOI: 10.1021/Ol900585T  1
2009 Kozikowski AP, Chen Y, Subhasish T, Lewin NE, Blumberg PM, Zhong Z, D'Annibale MA, Wang WL, Shen Y, Langley B. Searching for disease modifiers - PKC activation and HDAC inhibition - A dual drug approach to Alzheimer's disease that decreases Aβ production while blocking oxidative stress Chemmedchem. 4: 1095-1105. PMID 19396896 DOI: 10.1002/Cmdc.200900045  1
2009 Comin MJ, Czifra G, Kedei N, Telek A, Lewin NE, Kolusheva S, Velasquez JF, Kobylarz R, Jelinek R, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths. Journal of Medicinal Chemistry. 52: 3274-83. PMID 19379015 DOI: 10.1021/Jm900186M  1
2009 Choi HK, Choi S, Lee Y, Kang DW, Ryu H, Maeng HJ, Chung SJ, Pavlyukovets VA, Pearce LV, Toth A, Tran R, Wang Y, Morgan MA, Blumberg PM, Lee J. Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists. Bioorganic & Medicinal Chemistry. 17: 690-8. PMID 19135377 DOI: 10.1016/J.Bmc.2008.11.085  1
2009 Keck GE, Poudel YB, Welch DS, Kraft MB, Truong AP, Stephens JC, Kedei N, Lewin NE, Blumberg PM. Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters. Organic Letters. 11: 593-6. PMID 19113896 DOI: 10.1021/Ol8027253  1
2009 Stang SL, Lopez-Campistrous A, Song X, Dower NA, Blumberg PM, Wender PA, Stone JC. A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells. Experimental Hematology. 37: 122-134. PMID 19100522 DOI: 10.1016/J.Exphem.2008.09.008  1
2009 Pu Y, Garfield SH, Kedei N, Blumberg PM. Characterization of the differential roles of the twin C1a and C1b domains of protein kinase C-delta. The Journal of Biological Chemistry. 284: 1302-12. PMID 19001377 DOI: 10.1074/Jbc.M804796200  1
2009 Szegedi A, Páyer E, Czifra G, Tóth BI, Schmidt E, Kovács L, Blumberg PM, Bíró T. Protein kinase C isoenzymes differentially regulate the differentiation-dependent expression of adhesion molecules in human epidermal keratinocytes. Experimental Dermatology. 18: 122-9. PMID 18637128 DOI: 10.1111/J.1600-0625.2008.00771.X  1
2009 Lim JO, Jin MK, Ryu H, Kang DW, Lee J, Pearce LV, Tran R, Toth A, Blumberg PM. Conformationally constrained analogues of N'-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists. European Journal of Medicinal Chemistry. 44: 322-31. PMID 18406014 DOI: 10.1016/J.Ejmech.2008.02.026  1
2008 Philosof-Mazor L, Volinsky R, Comin MJ, Lewin NE, Kedei N, Blumberg PM, Marquez VE, Jelinek R. Self-assembly and lipid interactions of diacylglycerol lactone derivatives studied at the air/water interface. Langmuir : the Acs Journal of Surfaces and Colloids. 24: 11043-52. PMID 18788772 DOI: 10.1021/La802204N  1
2008 El Kazzouli S, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteins. Journal of Medicinal Chemistry. 51: 5371-86. PMID 18707088 DOI: 10.1021/Jm800380B  1
2008 Duan D, Sigano DM, Kelley JA, Lai CC, Lewin NE, Kedei N, Peach ML, Lee J, Abeyweera TP, Rotenberg SA, Kim H, Kim YH, El Kazzouli S, Chung JU, Young HA, ... ... Blumberg PM, et al. Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. Journal of Medicinal Chemistry. 51: 5198-220. PMID 18698758 DOI: 10.1021/Jm8001907  1
2008 Keck GE, Kraft MB, Truong AP, Li W, Sanchez CC, Kedei N, Lewin NE, Blumberg PM. Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function. Journal of the American Chemical Society. 130: 6660-1. PMID 18452293 DOI: 10.1021/Ja8022169  1
2008 Lomonaco SL, Kahana S, Blass M, Brody Y, Okhrimenko H, Xiang C, Finniss S, Blumberg PM, Lee HK, Brodie C. Phosphorylation of protein kinase Cδ on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1: Role in the apoptotic effect of etoposide Journal of Biological Chemistry. 283: 17731-17739. PMID 18434324 DOI: 10.1074/Jbc.M801727200  1
2008 Choi SH, Czifra G, Kedei N, Lewin NE, Lazar J, Pu Y, Marquez VE, Blumberg PM. Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta. The Journal of Biological Chemistry. 283: 10543-9. PMID 18263588 DOI: 10.1074/Jbc.M707463200  1
2008 Pearce LV, Toth A, Ryu H, Kang DW, Choi HK, Jin MK, Lee J, Blumberg PM. Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors. Naunyn-Schmiedeberg's Archives of Pharmacology. 377: 149-57. PMID 18259730 DOI: 10.1007/S00210-007-0258-3  1
2008 Gönczi M, Telek A, Czifra G, Balogh A, Blumberg PM, Bíró T, Csernoch L. Altered calcium handling following the recombinant overexpression of protein kinase C isoforms in HaCaT cells. Experimental Dermatology. 17: 584-91. PMID 18177346 DOI: 10.1111/J.1600-0625.2007.00678.X  1
2008 Ryu H, Jin MK, Kim SY, Choi HK, Kang SU, Kang DW, Lee J, Pearce LV, Pavlyukovets VA, Morgan MA, Tran R, Toth A, Lundberg DJ, Blumberg PM. Stereospecific high-affinity TRPV1 antagonists: chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues. Journal of Medicinal Chemistry. 51: 57-67. PMID 18072720 DOI: 10.1021/Jm701049P  1
2008 Zhu H, Yang Y, Zhang H, Han Y, Li Y, Zhang Y, Yin D, He Q, Zhao Z, Blumberg PM, Han J, Wang Y. Interaction between protein kinase D1 and transient receptor potential V1 in primary sensory neurons is involved in heat hypersensitivity. Pain. 137: 574-88. PMID 18063480 DOI: 10.1016/J.Pain.2007.10.025  1
2007 Blumberg PM. Lighting a backfire to quench the blaze: a combined drug approach targeting the vanilloid receptor TRPV1. Molecular Interventions. 7: 310-2. PMID 18199852 DOI: 10.1124/mi.7.6.5  0.01
2007 Chung JU, Kim SY, Lim JO, Choi HK, Kang SU, Yoon HS, Ryu H, Kang DW, Lee J, Kang B, Choi S, Toth A, Pearce LV, Pavlyukovets VA, Lundberg DJ, ... Blumberg PM, et al. Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists. Bioorganic & Medicinal Chemistry. 15: 6043-53. PMID 17629487 DOI: 10.1016/J.Bmc.2007.06.041  1
2007 Choi Y, Pu Y, Peach ML, Kang JH, Lewin NE, Sigano DM, Garfield SH, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta. Journal of Medicinal Chemistry. 50: 3465-81. PMID 17591763 DOI: 10.1021/Jm0702579  1
2007 Tang L, Chen Y, Chen Z, Blumberg PM, Kozikowski AP, Wang ZJ. Antinociceptive pharmacology of N-(4-chlorobenzyl)-N'-(4-hydroxy-3-iodo-5-methoxybenzyl) thiourea, a high-affinity competitive antagonist of the transient receptor potential vanilloid 1 receptor. The Journal of Pharmacology and Experimental Therapeutics. 321: 791-8. PMID 17312187 DOI: 10.1124/Jpet.106.117572  1
2007 Malolanarasimhan K, Kedei N, Sigano DM, Kelley JA, Lai CC, Lewin NE, Surawski RJ, Pavlyukovets VA, Garfield SH, Wincovitch S, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups. Journal of Medicinal Chemistry. 50: 962-78. PMID 17284021 DOI: 10.1021/Jm061289J  1
2007 Kang DW, Ryu H, Lee J, Lang KA, Pavlyukovets VA, Pearce LV, Ikeda T, Lazar J, Blumberg PM. Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin. Bioorganic & Medicinal Chemistry Letters. 17: 214-9. PMID 17035013 DOI: 10.1016/J.Bmcl.2006.09.059  1
2006 Pu Y, Peach ML, Garfield SH, Wincovitch S, Marquez VE, Blumberg PM. Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms. The Journal of Biological Chemistry. 281: 33773-88. PMID 16950780 DOI: 10.1074/Jbc.M606560200  1
2006 Mach UR, Lewin NE, Blumberg PM, Kozikowski AP. Synthesis and pharmacological evaluation of 8- and 9-substituted benzolactam-V8 derivatives as potent ligands for protein kinase C, a therapeutic target for Alzheimer's disease Chemmedchem. 1: 307-314. PMID 16892365 DOI: 10.1002/Cmdc.200500068  1
2006 Kang JH, Benzaria S, Sigano DM, Lewin NE, Pu Y, Peach ML, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions. Journal of Medicinal Chemistry. 49: 3185-203. PMID 16722637 DOI: 10.1021/Jm060011O  1
2006 Lee J, Kang JH, Han KC, Kim Y, Kim SY, Youn HS, Mook-Jung I, Kim H, Lo Han JH, Ha HJ, Kim YH, Marquez VE, Lewin NE, Pearce LV, Lundberg DJ, ... Blumberg PM, et al. Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators. Journal of Medicinal Chemistry. 49: 2028-36. PMID 16539391 DOI: 10.1021/Jm0509391  1
2006 Lazar J, Braun DC, Tóth A, Wang Y, Pearce LV, Pavlyukovets VA, Blumberg PM, Garfield SH, Wincovitch S, Choi HK, Lee J. Kinetics of penetration influence the apparent potency of vanilloids on TRPV1. Molecular Pharmacology. 69: 1166-73. PMID 16418338 DOI: 10.1124/Mol.105.019158  1
2006 Czifra G, Tóth IB, Marincsák R, Juhász I, Kovács I, Acs P, Kovács L, Blumberg PM, Bíró T. Insulin-like growth factor-I-coupled mitogenic signaling in primary cultured human skeletal muscle cells and in C2C12 myoblasts. A central role of protein kinase Cdelta. Cellular Signalling. 18: 1461-72. PMID 16403461 DOI: 10.1016/J.Cellsig.2005.11.007  1
2006 Lee J, Lee JH, Kim SY, Perry NA, Lewin NE, Ayres JA, Blumberg PM. 2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands. Bioorganic & Medicinal Chemistry. 14: 2022-31. PMID 16297629 DOI: 10.1016/J.Bmc.2005.10.051  1
2005 Kang JH, Peach ML, Pu Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C. Journal of Medicinal Chemistry. 48: 5738-48. PMID 16134942 DOI: 10.1021/Jm050352M  1
2005 Lee J, Kang SU, Kil MJ, Shin M, Lim JO, Choi HK, Jin MK, Kim SY, Kim SE, Lee YS, Min KH, Kim YH, Ha HJ, Tran R, Welter JD, ... ... Blumberg PM, et al. Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 15: 4136-42. PMID 16005215 DOI: 10.1016/J.Bmcl.2005.06.009  1
2005 Lee J, Jin MK, Kang SU, Kim SY, Lee J, Shin M, Hwang J, Cho S, Choi YS, Choi HK, Kim SE, Suh YG, Lee YS, Kim YH, Ha HJ, ... ... Blumberg PM, et al. Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 15: 4143-50. PMID 15993063 DOI: 10.1016/j.bmcl.2005.06.006  1
2005 Pu Y, Perry NA, Yang D, Lewin NE, Kedei N, Braun DC, Choi SH, Blumberg PM, Garfield SH, Stone JC, Duan D, Marquez VE. A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha. The Journal of Biological Chemistry. 280: 27329-38. PMID 15923197 DOI: 10.1074/Jbc.M414132200  1
2005 Qiang YW, Walsh K, Yao L, Kedei N, Blumberg PM, Rubin JS, Shaughnessy J, Rudikoff S. Wnts induce migration and invasion of myeloma plasma cells. Blood. 106: 1786-93. PMID 15886323 DOI: 10.1182/Blood-2005-01-0049  1
2005 Tóth A, Boczán J, Kedei N, Lizanecz E, Bagi Z, Papp Z, Edes I, Csiba L, Blumberg PM. Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain. Brain Research. Molecular Brain Research. 135: 162-8. PMID 15857679 DOI: 10.1016/J.Molbrainres.2004.12.003  1
2005 Tóth A, Wang Y, Kedei N, Tran R, Pearce LV, Kang SU, Jin MK, Choi HK, Lee J, Blumberg PM. Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1. Life Sciences. 76: 2921-32. PMID 15820503 DOI: 10.1016/J.Lfs.2004.10.056  1
2005 Okhrimenko H, Lu W, Xiang C, Ju D, Blumberg PM, Gomel R, Kazimirsky G, Brodie C. Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis. The Journal of Biological Chemistry. 280: 23643-52. PMID 15774464 DOI: 10.1074/Jbc.M501374200  1
2005 Braun DC, Garfield SH, Blumberg PM. Analysis by fluorescence resonance energy transfer of the interaction between ligands and protein kinase Cdelta in the intact cell. The Journal of Biological Chemistry. 280: 8164-71. PMID 15611119 DOI: 10.1074/Jbc.M413896200  1
2004 Wang Y, Kedei N, Wang M, Wang QJ, Huppler AR, Toth A, Tran R, Blumberg PM. Interaction between protein kinase Cmu and the vanilloid receptor type 1. The Journal of Biological Chemistry. 279: 53674-82. PMID 15471852 DOI: 10.1074/Jbc.M410331200  1
2004 Pearce LV, Petukhov PA, Szabo T, Kedei N, Bizik F, Kozikowski AP, Blumberg PM. Evodiamine functions as an agonist for the vanilloid receptor TRPV1 Organic and Biomolecular Chemistry. 2: 2281-2286. PMID 15305207 DOI: 10.1039/B404506H  1
2004 Kang JH, Siddiqui MA, Sigano DM, Krajewski K, Lewin NE, Pu Y, Blumberg PM, Lee J, Marquez VE. Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones. Organic Letters. 6: 2413-6. PMID 15228292 DOI: 10.1021/Ol0492041  1
2004 Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM. PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters. Molecular Pharmacology. 66: 76-84. PMID 15213298 DOI: 10.1124/Mol.66.1.76  1
2004 Lee J, Kim SY, Lee J, Kang M, Kil MJ, Choi HK, Jin MK, Wang Y, Toth A, Pearce LV, Lundberg DJ, Tran R, Blumberg PM. Analysis of structure-activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism. Bioorganic & Medicinal Chemistry. 12: 3411-20. PMID 15186827 DOI: 10.1016/J.Bmc.2004.04.040  1
2004 Kedei N, Lundberg DJ, Toth A, Welburn P, Garfield SH, Blumberg PM. Characterization of the interaction of ingenol 3-angelate with protein kinase C. Cancer Research. 64: 3243-55. PMID 15126366 DOI: 10.1158/0008-5472.Can-03-3403  1
2004 Lázár J, Szabó T, Marincsák R, Kovács L, Blumberg PM, Bíró T. Sensitization of recombinant vanilloid receptor-1 by various neurotrophic factors. Life Sciences. 75: 153-63. PMID 15120568 DOI: 10.1016/J.Lfs.2003.11.023  1
2004 Papp H, Czifra G, Bodó E, Lázár J, Kovács I, Aleksza M, Juhász I, Acs P, Sipka S, Kovács L, Blumberg PM, Bíró T. Opposite roles of protein kinase C isoforms in proliferation, differentiation, apoptosis, and tumorigenicity of human HaCaT keratinocytes. Cellular and Molecular Life Sciences : Cmls. 61: 1095-105. PMID 15112056 DOI: 10.1007/S00018-004-4014-2  1
2004 Lee J, Kang SU, Choi HK, Lee J, Lim JO, Kil MJ, Jin MK, Kim KP, Sung JH, Chung SJ, Ha HJ, Kim YH, Pearce LV, Tran R, Lundberg DJ, ... ... Blumberg PM, et al. Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity. Bioorganic & Medicinal Chemistry Letters. 14: 2291-7. PMID 15081027 DOI: 10.1016/J.Bmcl.2004.02.002  1
2004 Pettit GR, Hoffmann H, Herald DL, McNulty J, Murphy A, Higgs KC, Hamel E, Lewin NE, Pearce LV, Blumberg PM, Pettit RK, Knight JC. Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine. The Journal of Organic Chemistry. 69: 2251-6. PMID 15049616 DOI: 10.1021/Jo0300486  1
2004 Pettit GR, Hoffmann H, Herald DL, Blumberg PM, Hamel E, Schmidt JM, Chang Y, Pettit RK, Lewin NE, Pearce LV. Antineoplastic agents. 499. Synthesis of hystatin 2 and related 1H-benzo[de][1,6]-naphthyridinium salts from aaptamine. Journal of Medicinal Chemistry. 47: 1775-82. PMID 15027869 DOI: 10.1021/Jm030070R  1
2004 Gavva NR, Klionsky L, Qu Y, Shi L, Tamir R, Edenson S, Zhang TJ, Viswanadhan VN, Toth A, Pearce LV, Vanderah TW, Porreca F, Blumberg PM, Lile J, Sun Y, et al. Molecular determinants of vanilloid sensitivity in TRPV1. The Journal of Biological Chemistry. 279: 20283-95. PMID 14996838 DOI: 10.1074/Jbc.M312577200  1
2004 Lee J, Kim SY, Park S, Lim JO, Kim JM, Kang M, Lee J, Kang SU, Choi HK, Jin MK, Welter JD, Szabo T, Tran R, Pearce LV, Toth A, ... Blumberg PM, et al. Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding. Bioorganic & Medicinal Chemistry. 12: 1055-69. PMID 14980619 DOI: 10.1016/J.Bmc.2003.12.005  1
2004 Tóth A, Blumberg PM, Chen Z, Kozikowski AP. Design of a High-Affinity Competitive Antagonist of the Vanilloid Receptor Selective for the Calcium Entry-Linked Receptor Population Molecular Pharmacology. 65: 282-291. PMID 14742669 DOI: 10.1124/Mol.65.2.282  1
2004 Lee J, Kang SU, Lim JO, Choi HK, Jin MK, Toth A, Pearce LV, Tran R, Wang Y, Szabo T, Blumberg PM. N-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure-activity relationships for the "C-Region". Bioorganic & Medicinal Chemistry. 12: 371-85. PMID 14723956 DOI: 10.1016/J.Bmc.2003.10.047  1
2003 Wang QJ, Fang TW, Yang D, Lewin NE, Van Lint J, Marquez VE, Blumberg PM. Ligand structure-activity requirements and phospholipid dependence for the binding of phorbol esters to protein kinase D. Molecular Pharmacology. 64: 1342-8. PMID 14645664 DOI: 10.1124/Mol.64.6.1342  1
2003 Rambaratsingh RA, Stone JC, Blumberg PM, Lorenzo PS. RasGRP1 Represents a Novel Non-protein Kinase C Phorbol Ester Signaling Pathway in Mouse Epidermal Keratinocytes Journal of Biological Chemistry. 278: 52792-52801. PMID 14532295 DOI: 10.1074/jbc.M308240200  1
2003 Hamer DH, Bocklandt S, McHugh L, Chun TW, Blumberg PM, Sigano DM, Marquez VE. Rational design of drugs that induce human immunodeficiency virus replication. Journal of Virology. 77: 10227-36. PMID 12970407 DOI: 10.1128/Jvi.77.19.10227-10236.2003  1
2003 Sridhar J, Wei ZL, Nowak I, Lewin NE, Ayres JA, Pearce LV, Blumberg PM, Kozikowski AP. New bivalent PKC ligands linked by a carbon spacer: Enhancement in binding affinity Journal of Medicinal Chemistry. 46: 4196-4204. PMID 12954072 DOI: 10.1021/Jm0302041  1
2003 Bocklandt S, Blumberg PM, Hamer DH. Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate. Antiviral Research. 59: 89-98. PMID 12895692 DOI: 10.1016/S0166-3542(03)00034-2  1
2003 Wang Y, Toth A, Tran R, Szabo T, Welter JD, Blumberg PM, Lee J, Kang SU, Lim JO, Lee J. High-affinity partial agonists of the vanilloid receptor. Molecular Pharmacology. 64: 325-33. PMID 12869637 DOI: 10.1124/Mol.64.2.325  1
2003 Lee J, Lee J, Kang M, Shin M, Kim JM, Kang SU, Lim JO, Choi HK, Suh YG, Park HG, Oh U, Kim HD, Park YH, Ha HJ, Kim YH, ... ... Blumberg PM, et al. N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor. Journal of Medicinal Chemistry. 46: 3116-26. PMID 12825950 DOI: 10.1021/Jm030089U  1
2003 Kang JH, Chung HE, Kim SY, Kim Y, Lee J, Lewin NE, Pearce LV, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones Bioorganic and Medicinal Chemistry. 11: 2529-2539. PMID 12757721 DOI: 10.1016/S0968-0896(03)00156-1  1
2003 Kozikowski AP, Nowak I, Petukhov PA, Etcheberrigaray R, Mohamed A, Tan M, Lewin N, Hennings H, Pearce LL, Blumberg PM. New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα Journal of Medicinal Chemistry. 46: 364-373. PMID 12540236 DOI: 10.1021/Jm020350R  1
2003 Brodie C, Blumberg PM. Regulation of cell apoptosis by protein kinase c delta. Apoptosis : An International Journal On Programmed Cell Death. 8: 19-27. PMID 12510148 DOI: 10.1023/A:1021640817208  1
2002 Pettit GR, Ducki S, Tan R, Gardella RS, McMahon JB, Boyd MR, Pettit GR, Blumberg PM, Lewin NE, Doubek DL, Tackett LP, Williams MD. Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp. Journal of Natural Products. 65: 1262-5. PMID 12350143 DOI: 10.1021/Np020115B  1
2002 Wang Y, Szabo T, Welter JD, Toth A, Tran R, Lee J, Kang SU, Suh YG, Blumberg PM, Lee J. High affinity antagonists of the vanilloid receptor. Molecular Pharmacology. 62: 947-56. PMID 12237342 DOI: 10.1124/Mol.62.4.947  1
2002 Wei ZL, Sakamuri S, Petukhov PA, George C, Lewin NE, Blumberg PM, Kozikowski AP. Synthesis and modeling study of (2S,5R,6R)- and (2S,5R,6S)-6-Hydroxy-8-(1-decynyl)-benzolactam-V8 as protein kinase C modulators Organic Letters. 4: 2169-2172. PMID 12074659 DOI: 10.1021/Ol026013U  1
2002 Tóth A, Kedei N, Szabó T, Wang Y, Blumberg PM. Thapsigargin binds to and inhibits the cloned vanilloid receptor-1. Biochemical and Biophysical Research Communications. 293: 777-82. PMID 12054538 DOI: 10.1016/S0006-291X(02)00293-0  1
2002 Zrachia A, Dobroslav M, Blass M, Kazimirsky G, Kronfeld I, Blumberg PM, Kobiler D, Lustig S, Brodie C. Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis. The Journal of Biological Chemistry. 277: 23693-701. PMID 11927579 DOI: 10.1074/jbc.M111658200  1
2002 Lee J, Lee J, Kang MS, Kim KP, Chung SJ, Blumberg PM, Yi JB, Park YH. Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics. Bioorganic & Medicinal Chemistry. 10: 1171-9. PMID 11836128 DOI: 10.1016/S0968-0896(01)00387-X  1
2002 Szabo T, Biro T, Gonzalez AF, Palkovits M, Blumberg PM. Pharmacological characterization of vanilloid receptor located in the brain. Brain Research. Molecular Brain Research. 98: 51-7. PMID 11834295 DOI: 10.1016/S0169-328X(01)00313-8  1
2002 Rong SB, Enyedy IJ, Qiao L, Zhao L, Ma D, Pearce LL, Lorenzo PS, Stone JC, Blumberg PM, Wang S, Kozikowski AP. Structural basis of RasGRP binding to high-affinity PKC ligands. Journal of Medicinal Chemistry. 45: 853-60. PMID 11831896 DOI: 10.1021/Jm010422Z  1
2002 Blass M, Kronfeld I, Kazimirsky G, Blumberg PM, Brodie C. Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide. Molecular and Cellular Biology. 22: 182-95. PMID 11739733 DOI: 10.1128/Mcb.22.1.182-195.2002  1
2002 Garcia-Bermejo ML, Leskow FC, Fujii T, Wang Q, Blumberg PM, Ohba M, Kuroki T, Han KC, Lee J, Marquez VE, Kazanietz MG. Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha. The Journal of Biological Chemistry. 277: 645-55. PMID 11584014 DOI: 10.1074/Jbc.M107639200  1
2002 Nacro K, Lee J, Barchi JJ, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). Part 19: Asymmetric syntheses of (3R)- and (3S)-3-hydroxy-4,4-disubstituted heptono-1,4-lactones as protein kinase C (PK-C) ligands with increased hydrophilicity Tetrahedron. 58: 5335-5345. DOI: 10.1016/S0040-4020(02)00477-5  1
2001 Kuzhikandathil EV, Wang H, Szabo T, Morozova N, Blumberg PM, Oxford GS. Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 8697-706. PMID 11698581 DOI: 10.1523/Jneurosci.21-22-08697.2001  1
2001 Shao L, Lewin NE, Lorenzo PS, Hu Z, Enyedy IJ, Garfield SH, Stone JC, Marner FJ, Blumberg PM, Wang S. Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily. Journal of Medicinal Chemistry. 44: 3872-80. PMID 11689073 DOI: 10.1021/Jm010258F  1
2001 Lee J, Lee J, Szabo T, Gonzalez AF, Welter JD, Blumberg PM. N-(3-acyloxy-2-benzylpropyl)-N'-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline thiourea analogues as vanilloid receptor ligands. Bioorganic & Medicinal Chemistry. 9: 1713-20. PMID 11425572 DOI: 10.1016/S0968-0896(01)00068-2  1
2001 Nacro K, Sigano DM, Yan S, Nicklaus MC, Pearce LL, Lewin NE, Garfield SH, Blumberg PM, Marquez VE. An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P). Journal of Medicinal Chemistry. 44: 1892-904. PMID 11384235 DOI: 10.1021/Jm010052E  1
2001 Kedei N, Szabo T, Lile JD, Treanor JJ, Olah Z, Iadarola MJ, Blumberg PM. Analysis of the native quaternary structure of vanilloid receptor 1. The Journal of Biological Chemistry. 276: 28613-9. PMID 11358970 DOI: 10.1074/Jbc.M103272200  1
2001 Lee J, Lee J, Kim J, Kim SY, Chun MW, Cho H, Hwang SW, Oh U, Park YH, Marquez VE, Beheshti M, Szabo T, Blumberg PM. N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics. Bioorganic & Medicinal Chemistry. 9: 19-32. PMID 11197340 DOI: 10.1016/S0968-0896(00)00216-9  1
2001 Olah Z, Szabo T, Karai L, Hough C, Fields RD, Caudle RM, Blumberg PM, Iadarola MJ. Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1. The Journal of Biological Chemistry. 276: 11021-30. PMID 11124944 DOI: 10.1074/Jbc.M008392200  1
2000 Kronfeld I, Kazimirsky G, Lorenzo PS, Garfield SH, Blumberg PM, Brodie C. Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions. The Journal of Biological Chemistry. 275: 35491-8. PMID 10945993 DOI: 10.1074/Jbc.M005991200  1
2000 Wang QJ, Fang TW, Fenick D, Garfield S, Bienfait B, Marquez VE, Blumberg PM. The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein. The Journal of Biological Chemistry. 275: 12136-46. PMID 10766849 DOI: 10.1074/Jbc.275.16.12136  1
2000 Mezey E, Tóth ZE, Cortright DN, Arzubi MK, Krause JE, Elde R, Guo A, Blumberg PM, Szallasi A. Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proceedings of the National Academy of Sciences of the United States of America. 97: 3655-60. PMID 10725386 DOI: 10.1073/Pnas.97.7.3655  1
1999 Wang QJ, Bhattacharyya D, Garfield S, Nacro K, Marquez VE, Blumberg PM. Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein. The Journal of Biological Chemistry. 274: 37233-9. PMID 10601287 DOI: 10.1074/Jbc.274.52.37233  1
1999 Lee J, Park SU, Kim JY, Kim JK, Lee J, Oh U, Marquez VE, Beheshti M, Wang QJ, Modarres S, Blumberg PM. 3-Acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid as novel vanilloid receptor agonists. Bioorganic & Medicinal Chemistry Letters. 9: 2909-14. PMID 10571146 DOI: 10.1016/S0960-894X(99)00513-2  1
1999 Szabo T, Olah Z, Iadarola MJ, Blumberg PM. Epidural resiniferatoxin induced prolonged regional analgesia to pain. Brain Research. 840: 92-8. PMID 10517956 DOI: 10.1016/S0006-8993(99)01763-1  1
1999 Lee J, Kang JH, Lee SY, Han KC, Torres CM, Bhattacharyya DK, Blumberg PM, Marquez VE. Protein kinase C ligands based on tetrahydrofuran templates containing a new set of phorbol ester pharmacophores Journal of Medicinal Chemistry. 42: 4129-4139. PMID 10514283 DOI: 10.1021/Jm980713G  1
1999 Szallasi A, Szabó T, Bíró T, Modarres S, Blumberg PM, Krause JE, Cortright DN, Appendino G. Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1. British Journal of Pharmacology. 128: 428-34. PMID 10510454 DOI: 10.1038/sj.bjp.0702810  1
1999 Szallasi A, Blumberg PM, Annicelli LL, Krause JE, Cortright DN. The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons. Molecular Pharmacology. 56: 581-7. PMID 10462546 DOI: 10.1124/Mol.56.3.581  1
1999 Swann PG, Odom S, Zhou YJ, Szallasi Z, Blumberg PM, Draber P, Rivera J. Requirement for a negative charge at threonine 60 of the FcRγ for complete activation of Syk Journal of Biological Chemistry. 274: 23068-23077. PMID 10438475 DOI: 10.1074/jbc.274.33.23068  1
1999 Szallasi A, Bíró T, Szabó T, Modarres S, Petersen M, Klusch A, Blumberg PM, Krause JE, Sterner O. A non-pungent triprenyl phenol of fungal origin, scutigeral, stimulates rat dorsal root ganglion neurons via interaction at vanilloid receptors. British Journal of Pharmacology. 126: 1351-8. PMID 10217528 DOI: 10.1038/sj.bjp.0702440  1
1999 Romanova LY, Alexandrov IA, Blagosklonny MV, Nordan RP, Garfield S, Acs P, Nguyen P, Trepel J, Blumberg PM, Mushinski JF. Regulation of actin cytoskeleton in lymphocytes: PKC-delta disrupts IL-3-induced membrane ruffles downstream of Rac1. Journal of Cellular Physiology. 179: 157-69. PMID 10199555 DOI: 10.1002/(Sici)1097-4652(199905)179:2<157::Aid-Jcp6>3.0.Co;2-4  1
1999 Winkler JD, Kim S, Harrison S, Lewin NE, Blumberg PM. Synthesis and biological evaluation of highly functionalized analogues of ingenol Journal of the American Chemical Society. 121: 296-300. DOI: 10.1021/Ja9741842  1
1998 Brodie C, Bogi K, Acs P, Lorenzo PS, Baskin L, Blumberg PM. Protein kinase C delta (PKCdelta) inhibits the expression of glutamine synthetase in glial cells via the PKCdelta regulatory domain and its tyrosine phosphorylation. The Journal of Biological Chemistry. 273: 30713-8. PMID 9804846 DOI: 10.1074/Jbc.273.46.30713  1
1998 Szallasi A, Bíró T, Modarres S, Garlaschelli L, Petersen M, Klusch A, Vidari G, Jonassohn M, De Rosa S, Sterner O, Blumberg PM, Krause JE. Dialdehyde sesquiterpenes and other terpenoids as vanilloids. European Journal of Pharmacology. 356: 81-9. PMID 9761427 DOI: 10.1016/S0014-2999(98)00514-7  1
1998 Brodie C, Blumberg PM, Jacobson KA. Activation of the A2A adenosine receptor inhibits nitric oxide production in glial cells. Febs Letters. 429: 139-42. PMID 9650577 DOI: 10.1016/S0014-5793(98)00556-0  1
1998 Brodie C, Kuperstein I, Acs P, Blumberg PM. Differential role of specific PKC isoforms in the proliferation of glial cells and the expression of the astrocytic markers GFAP and glutamine synthetase. Brain Research. Molecular Brain Research. 56: 108-17. PMID 9602083 DOI: 10.1016/S0169-328X(98)00035-7  1
1997 Acs P, Wang QJ, Bögi K, Marquez AM, Lorenzo PS, Bíró T, Szállási Z, Mushinski JF, Blumberg PM. Both the catalytic and regulatory domains of protein kinase C chimeras modulate the proliferative properties of NIH 3T3 cells. The Journal of Biological Chemistry. 272: 28793-9. PMID 9353351 DOI: 10.1074/Jbc.272.45.28793  1
1997 Acs P, Bögi K, Lorenzo PS, Marquez AM, Bíró T, Szállási Z, Blumberg PM. The catalytic domain of protein kinase C chimeras modulates the affinity and targeting of phorbol ester-induced translocation. The Journal of Biological Chemistry. 272: 22148-53. PMID 9268359 DOI: 10.1074/Jbc.272.35.22148  1
1997 Rosson D, O'Brien TG, Kampherstein JA, Szallasi Z, Bogi K, Blumberg PM, Mullin JM. Protein kinase C-alpha activity modulates transepithelial permeability and cell junctions in the LLC-PK1 epithelial cell line. The Journal of Biological Chemistry. 272: 14950-3. PMID 9169467 DOI: 10.1074/Jbc.272.23.14950  1
1997 Hurley JH, Newton AC, Parker PJ, Blumberg PM, Nishizuka Y. Taxonomy and function of C1 protein kinase C homology domains. Protein Science : a Publication of the Protein Society. 6: 477-80. PMID 9041654 DOI: 10.1002/Pro.5560060228  1
1997 Wang QJ, Acs P, Goodnight J, Giese T, Blumberg PM, Mischak H, Mushinski JF. The catalytic domain of protein kinase C-delta in reciprocal delta and epsilon chimeras mediates phorbol ester-induced macrophage differentiation of mouse promyelocytes. The Journal of Biological Chemistry. 272: 76-82. PMID 8995230 DOI: 10.1074/JBC.272.1.76  1
1996 Noland TA, Raynor RL, Jideama NM, Guo X, Kazanietz MG, Blumberg PM, Solaro RJ, Kuo JF. Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants. Biochemistry. 35: 14923-31. PMID 8942657 DOI: 10.1021/bi9616357  1
1996 Szallasi A, Acs G, Cravotto G, Blumberg PM, Lundberg JM, Appendino G. A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor. European Journal of Pharmacology. 299: 221-8. PMID 8901026 DOI: 10.1016/0014-2999(95)00864-0  1
1996 Pettit GR, Gao F, Blumberg PM, Herald CL, Coll JC, Kamano Y, Lewin NE, Schmidt JM, Chapuis JC. Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18. Journal of Natural Products. 59: 286-9. PMID 8882431 DOI: 10.1021/Np960100B  1
1996 Szallasi A, Nilsson S, Blumberg PM, Hökfelt T, Lundberg JM. Binding of neuroleptic drugs (trifluoperazine and rimcazole) to vanilloid receptors in porcine dorsal horn. European Journal of Pharmacology. 298: 321-7. PMID 8846833 DOI: 10.1016/0014-2999(95)00805-5  1
1996 Jideama NM, Noland TA, Raynor RL, Blobe GC, Fabbro D, Kazanietz MG, Blumberg PM, Hannun YA, Kuo JF. Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. The Journal of Biological Chemistry. 271: 23277-83. PMID 8798526 DOI: 10.1074/Jbc.271.38.23277  1
1996 Farkas-Szallasi T, Bennett GJ, Blumberg PM, Hökfelt T, Lundberg JM, Szallasi A. Vanilloid receptor loss is independent of the messenger plasticity that follows systemic resiniferatoxin administration. Brain Research. 719: 213-8. PMID 8782884 DOI: 10.1016/0006-8993(96)00065-0  1
1995 Szallasi A, Nilsson S, Farkas-Szallasi T, Blumberg PM, Hökfelt T, Lundberg JM. Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment. Brain Research. 703: 175-83. PMID 8719630 DOI: 10.1016/0006-8993(95)01094-7  1
1995 Kazanietz MG, Barchi JJ, Omichinski JG, Blumberg PM. Low affinity binding of phorbol esters to protein kinase C and its recombinant cysteine-rich region in the absence of phospholipids Journal of Biological Chemistry. 270: 14679-14684. PMID 7782331 DOI: 10.1074/Jbc.270.24.14679  1
1995 Zhang G, Kazanietz MG, Blumberg PM, Hurley JH. Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester. Cell. 81: 917-24. PMID 7781068 DOI: 10.1016/0092-8674(95)90011-X  1
1995 Szallasi A, Blumberg PM, Lundberg JM. Proton inhibition of [3H]resiniferatoxin binding to vanilloid (capsaicin) receptors in rat spinal cord. European Journal of Pharmacology. 289: 181-7. PMID 7621890 DOI: 10.1016/0922-4106(95)90093-4  1
1995 Szallasi Z, Denning MF, Chang EY, Rivera J, Yuspa SH, Lehel C, Olah Z, Anderson WB, Blumberg PM. Development of a rapid approach to identification of tyrosine phosphorylation sites: Application to PKCδ phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells Biochemical and Biophysical Research Communications. 214: 888-894. PMID 7575560 DOI: 10.1006/Bbrc.1995.2370  1
1994 Szallasi A, Blumberg PM, Nilsson S, Hökfelt T, Lundberg JM. Visualization by [3H]resiniferatoxin autoradiography of capsaicin-sensitive neurons in the rat, pig and man. European Journal of Pharmacology. 264: 217-21. PMID 7851486 DOI: 10.1016/0014-2999(94)00526-5  1
1993 Winkler JD, Hong BC, Bahador A, Kazanietz MG, Blumberg PM. Synthesis of ingenol analogs wth affinity for protein kinase C Bioorganic and Medicinal Chemistry Letters. 3: 577-580. DOI: 10.1016/S0960-894X(01)81232-4  1
1992 Gustafson KR, Cardellina JH, McMahon JB, Gulakowski RJ, Ishitoya J, Szallasi Z, Lewin NE, Blumberg PM, Weislow OS, Beutler JA. A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. Journal of Medicinal Chemistry. 35: 1978-86. PMID 1597853 DOI: 10.1021/Jm00089A006  1
1992 Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF, Mischak H. The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-zeta. Gene. 122: 305-11. PMID 1487145 DOI: 10.1016/0378-1119(92)90219-F  1
1992 Teng K, Marquez VE, Milne GWA, Barchi JJ, Kazanietz MG, Lewin NE, Blumberg PM, Abushanab E. Conformationally constrained analogues of diacylglycerol. Interaction of γ-lactones with the phorbol ester receptor of protein kinase C Journal of the American Chemical Society. 114: 1059-1070.  1
1991 Szolcsanyi J, Szallasi A, Szallasi Z, Joo F, Blumberg PM. Resiniferatoxin. An ultrapotent neurotoxin of capsaicin-sensitive primary afferent neurons. Annals of the New York Academy of Sciences. 632: 473-5. PMID 1952635 DOI: 10.1111/J.1749-6632.1991.TB33161.X  1
1989 Tauber AI, Cox JA, Curnutte JT, Carrol PM, Nakakuma H, Warren B, Gilbert H, Blumberg PM. Activation of human neutrophil NADPH-oxidase in vitro by the catalytic fragment of protein kinase-C. Biochemical and Biophysical Research Communications. 158: 884-90. PMID 2920044 DOI: 10.1016/0006-291X(89)92805-2  1
1989 Szallasi A, Joo F, Blumberg PM. Duration of desensitization and ultrastructural changes in dorsal root ganglia in rats treated with resiniferatoxin, an ultrapotent capsaicin analog. Brain Research. 503: 68-72. PMID 2611660 DOI: 10.1016/0006-8993(89)91705-8  1
1989 Pettit GR, Kamano Y, Schaufelberger D, Herald CL, Blumberg PM, May SW. High performance liquid chromatographic separation of bryostatins 1–12 Journal of Liquid Chromatography. 12: 553-561. DOI: 10.1080/01483918908051757  1
1988 Wender PA, Cribbs CM, Koehler KF, Sharkey NA, Herald CL, Kamano Y, Pettit GR, Blumberg PM. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 85: 7197-201. PMID 3174627 DOI: 10.1073/Pnas.85.19.7197  1
1987 Lacal JC, Fleming TP, Warren BS, Blumberg PM, Aaronson SA. Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product Molecular and Cellular Biology. 7: 4146-4149. PMID 3323889 DOI: 10.1128/Mcb.7.11.4146  1
1987 Leach KL, Frost MM, Blumberg PM, Bressler JP. Second stage tumor promoters: Differences in biological potency and phorbol ester receptor affinity in C6 cells Cancer Letters. 36: 139-147. PMID 3040225 DOI: 10.1016/0304-3835(87)90085-1  1
1987 BLUMBERG PM, NAKADATE T, WARREN BS, DELL'AQUILA M, SAKO T, PASTI G, SHARKEY NA. Phorbol esters as probes of the modulatory site on protein kinase C–an overview Botanical Journal of the Linnean Society. 94: 283-292. DOI: 10.1111/J.1095-8339.1987.Tb01051.X  1
1986 Sharkey NA, Blumberg PM. Short communication: Comparison of the activity of phorbol 12-myristate 13-acetate and the diglyceride glycerol 1-myristate 2-acetate Carcinogenesis. 7: 677-679. PMID 3486050 DOI: 10.1093/Carcin/7.4.677  1
1986 Wender PA, Koehler KF, Sharkey NA, Dell'Aquila ML, Blumberg PM. Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs. Proceedings of the National Academy of Sciences of the United States of America. 83: 4214-8. PMID 3086877 DOI: 10.1073/Pnas.83.12.4214  1
1985 Blumberg PM, Leach KL, König B, Jeng AY, Sharkey NA. Receptors for the phorbol ester tumour promoters Ciba Foundation Symposium. 116: 205-223. PMID 4075903 DOI: 10.1002/9780470720974.ch13  1
1985 Sharkey NA, Blumberg PM. Kinetic evidence that 1,2-diolein inhibits phorbol ester binding to protein kinase C via a competitive mechanism Biochemical and Biophysical Research Communications. 133: 1051-1056. PMID 3936500 DOI: 10.1016/0006-291X(85)91242-2  1
1985 Cox JA, Jeng AY, Sharkey NA, Blumberg PM, Tauber AI. Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C Journal of Clinical Investigation. 76: 1932-1938. PMID 2997297 DOI: 10.1172/Jci112190  1
1984 Blumberg PM, Jaken S, König B, Sharkey NA, Leach KL, Jeng AY, Yeh E. Mechanism of action of the phorbol ester tumor promoters: Specific receptors for lipophilic ligands Biochemical Pharmacology. 33: 933-940. PMID 6324806 DOI: 10.1016/0006-2952(84)90448-9  1
1984 Sharkey NA, Leach KL, Blumberg PM. Competitive inhibition by diacylglycerol of specific phorbol ester binding Proceedings of the National Academy of Sciences of the United States of America. 81: 607-610. PMID 6320198 DOI: 10.1073/Pnas.81.2.607  1
1983 Blumberg PM, Delclos KB, Dunn JA, Jaken S, Leach KL, Yeh E. Phorbol ester receptors and the in vitro effects of tumor promoters Annals of the New York Academy of Sciences. 407: 303-315. PMID 6309054 DOI: 10.1111/J.1749-6632.1983.Tb47836.X  1
1983 Leach KL, James ML, Blumberg PM. Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol Proceedings of the National Academy of Sciences of the United States of America. 80: 4208-4212. PMID 6308606 DOI: 10.1073/Pnas.80.14.4208  1
1982 Burstein DE, Blumberg PM, Greene LA. Nerve growth factor-induced neuronal differentiation of PC12 pheochromocytoma cells: Lack of inhibition by a tumor promoter Brain Research. 247: 115-119. PMID 7127107 DOI: 10.1016/0006-8993(82)91033-2  1
1982 Tauber AI, Brettler DB, Kennington EA, Blumberg PM. Relation of human neutrophil phorbol ester receptor occupancy and NADPH-oxidase activity Blood. 60: 333-339. PMID 6953983 DOI: 10.1182/Blood.V60.2.333.333  1
1982 Lew KK, Chritton S, Blumberg PM. Biological responsiveness to the phorbol esters and specific binding of [3H]phorbol 12,13-dibutyrate in the nematode Caenorhabditis elegans, a manipulable genetic system. Teratogenesis, Carcinogenesis, and Mutagenesis. 2: 19-30. PMID 6122277 DOI: 10.1002/1520-6866(1990)2:1<19::AID-TCM1770020104>3.0.CO;2-3  0.01
1981 Blumberg PM, Butler-Gralla E, Herschman HR. Analysis of phorbol ester receptors in phorbol ester unresponsive 3T3 cell variants. Biochemical and Biophysical Research Communications. 102: 818-23. PMID 6946773 DOI: 10.1016/0006-291X(81)91611-9  0.01
1980 Dunphy WG, Lau CC, Blumberg PM. Phorbol related diterpene esters have similar structure-activity relations in swiss 3t3 cells and chicken embryo fibroblasts Carcinogenesis. 1: 347-351. PMID 7273274 DOI: 10.1093/carcin/1.4.347  1
1980 Goldberg AR, Barry Delclos K, Blumberg PM. Phorbol ester action is independent of viral and cellular src kinase levels Science. 208: 191-192. PMID 6244621 DOI: 10.1126/science.6244621  1
1975 Blumberg PM, Strominger JL. Covalent affinity chromatography of penicillin-binding components from bacterial membranes. Methods in Enzymology. 34: 401-5. PMID 4217420 DOI: 10.1016/S0076-6879(74)34046-3  1
1975 Robbins PW, Wickus GG, Branton PE, Gaffney BJ, Hirschberg CB, Fuchs P, Blumberg P. The chick fibroblast cell surface after transformation by Rous sarcoma virus. Cold Spring Harbor Symposia On Quantitative Biology. 39: 1173-80. PMID 169019 DOI: 10.1101/Sqb.1974.039.01.135  0.01
1974 Strominger JL, Willoughby E, Kamiryo T, Blumberg PM, Yocum RR. Penicillin-sensitive enzymes and penicillin-binding components in bacterial cells. Annals of the New York Academy of Sciences. 235: 210-24. PMID 4277601 DOI: 10.1111/J.1749-6632.1974.Tb43267.X  1
1974 Anwar RA, Blumberg PM, Strominger JL. Penicillin binding components in Bacillus subtilis during sporulation Journal of Bacteriology. 117: 924-925. PMID 4204446 DOI: 10.1128/Jb.117.2.924-925.1974  1
1974 Blumberg PM, Strominger JL. Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes. Bacteriological Reviews. 38: 291-335. DOI: 10.1128/mmbr.38.3.291-335.1974  1
1974 Sharpe A, Blumberg PM, Strominger JL. d-Alanine Carboxypeptidase and Cell Wall Cross-Linking in Bacillus subtilis Journal of Bacteriology. 117: 926-927. DOI: 10.1128/jb.117.2.926-927.1974  1
1974 Anwar RA, Blumberg PM, Strominger JL. Penicillin Binding Components in Bacillius subtilis During Sporulation Journal of Bacteriology. 117: 924-925. DOI: 10.1128/jb.117.2.924-925.1974  1
1974 Storm DR, Blumberg PM, Strominger JL. Inhibition of the Bacillus subtilis Membrane-Bound d-Alanine Carboxypeptidase by 6-Aminopenicillanic Acid Covalently Coupled to Sepharose Journal of Bacteriology. 117: 783-785. DOI: 10.1128/Jb.117.2.783-785.1974  1
1974 Matsuhashi S, Kamiryo T, Blumberg PM, Linnett P, Willoughby E, Strominger JL. Mechanism of Action and Development of Resistance to a New Amidino Penicillin Journal of Bacteriology. 117: 578-587. DOI: 10.1128/jb.117.2.578-587.1974  1
1973 Blumberg PM, Strominger JL. Isolation by covalent affinity chromatography of the penicillin-binding components from membranes of Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 69: 3751-5. PMID 4630162 DOI: 10.1073/Pnas.69.12.3751  1
1972 Blumberg PM, Strominger JL. Inactivation of D-alanine carboxypeptidase by penicillins and cephalosporins is not lethal in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 68: 2814-7. PMID 4330943 DOI: 10.1073/Pnas.68.11.2814  1
1971 Steiner LA, Blumberg PM. Mercury derivatives of the fab and Fc fragments of a human myeloma protein Biochemistry. 10: 4725-4739. PMID 5003799 DOI: 10.1021/Bi00801A020  1
1971 Strominger JL, Blumberg PM, Suginaka H, Umbreit J, Wickus GG. How penicillin kills bacteria: progress and problems. Proceedings of the Royal Society of London. Series B, Biological Sciences. 179: 369-83. PMID 4401416 DOI: 10.1098/Rspb.1971.0103  1
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