| Year |
Citation |
Score |
| 2015 |
Pertusati F, McGuigan C, Serpi M. Symmetrical diamidate prodrugs of nucleotide analogues for drug delivery. Current Protocols in Nucleic Acid Chemistry. 60: 15.6.1-15.6.10. PMID 25754890 DOI: 10.1002/0471142700.nc1506s60 |
0.323 |
|
| 2011 |
McGuigan C, Madela K, Aljarah M, Bourdin C, Arrica M, Barrett E, Jones S, Kolykhalov A, Bleiman B, Bryant KD, Ganguly B, Gorovits E, Henson G, Hunley D, Hutchins J, et al. Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents. Journal of Medicinal Chemistry. 54: 8632-45. PMID 22039920 DOI: 10.1021/Jm2011673 |
0.344 |
|
| 2011 |
McGuigan C, Murziani P, Slusarczyk M, Gonczy B, Vande Voorde J, Liekens S, Balzarini J. Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside. Journal of Medicinal Chemistry. 54: 7247-58. PMID 21892829 DOI: 10.1021/jm200815w |
0.304 |
|
| 2011 |
Trippier PC, Balzarini J, McGuigan C. Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: bisphenylboronic acids. Antiviral Chemistry & Chemotherapy. 21: 129-42. PMID 21233534 DOI: 10.3851/IMP1707 |
0.604 |
|
| 2010 |
Derudas M, Quintiliani M, Brancale A, Andrei G, Snoeck R, Balzarini J, McGuigan C. Evaluation of novel phosphoramidate ProTides of the 2'-fluoro derivatives of a potent anti-varicella zoster virus bicyclic nucleoside analogue. Antiviral Chemistry & Chemotherapy. 21: 15-31. PMID 21045257 DOI: 10.3851/IMP1661 |
0.309 |
|
| 2010 |
Trippier PC, McGuigan C, Balzarini J. Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: monophenylboronic acids. Antiviral Chemistry & Chemotherapy. 20: 249-57. PMID 20710065 DOI: 10.3851/IMP1632 |
0.607 |
|
| 2010 |
Derudas M, Brancale A, Naesens L, Neyts J, Balzarini J, McGuigan C. Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin. Bioorganic & Medicinal Chemistry. 18: 2748-55. PMID 20207546 DOI: 10.1016/j.bmc.2010.02.015 |
0.338 |
|
| 2010 |
Trippier PC, McGuigan C. Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications Medchemcomm. 1: 183. DOI: 10.1039/C0MD00119H |
0.58 |
|
| 2010 |
MCGUIGAN C, TURNER S, MAHMOOD N, HAY AJ. ChemInform Abstract: A Rapid Synthesis of Some 5′-Amino-nucleosides and Nucleotides as Potential Antiviral Compounds. Cheminform. 28: no-no. DOI: 10.1002/CHIN.199714190 |
0.301 |
|
| 2010 |
MCGUIGAN C, NARASHINAN P. ChemInform Abstract: Synthesis of Some Amino Acid Linked Nitrogen Mustard Derivatives. Cheminform. 24: no-no. DOI: 10.1002/CHIN.199339246 |
0.339 |
|
| 2007 |
Perrone P, Daverio F, Valente R, Rajyaguru S, Martin JA, Lévêque V, Le Pogam S, Najera I, Klumpp K, Smith DB, McGuigan C. First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus. Journal of Medicinal Chemistry. 50: 5463-70. PMID 17914786 DOI: 10.1021/jm070362i |
0.337 |
|
| 2006 |
Congiatu C, Brancale A, Mason MD, Jiang WG, McGuigan C. Novel potential anticancer naphthyl phosphoramidates of BVdU: separation of diastereoisomers and assignment of the absolute configuration of the phosphorus center. Journal of Medicinal Chemistry. 49: 452-5. PMID 16420029 DOI: 10.1021/JM0509896 |
0.312 |
|
| 2005 |
Luoni GM, McGuigan C, Andrei G, Snoeck R, De Clercq E, Balzarini J. Bicyclic nucleoside inhibitors of varicella-zoster virus modified on the sugar moiety: 3' and 5' derivatives. Antiviral Chemistry & Chemotherapy. 15: 333-41. PMID 15646647 DOI: 10.1177/095632020401500606 |
0.306 |
|
| 2004 |
McGuigan C, Carangio A, Snoeck R, Andrei G, De Clercq E, Balzarini J. Synthesis and antiviral evaluation of some 3'-fluoro bicyclic nucleoside analogues. Nucleosides, Nucleotides & Nucleic Acids. 23: 1-5. PMID 15043132 DOI: 10.1081/NCN-120027813 |
0.303 |
|
| 2004 |
McGuigan C, Pathirana RN, Snoeck R, Andrei G, De Clercq E, Balzarini J. Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides: action via a novel non-nucleosidic mechanism. Journal of Medicinal Chemistry. 47: 1847-51. PMID 15027877 DOI: 10.1021/JM030857H |
0.325 |
|
| 2003 |
Luoni G, McGuigan C, Andrei G, Snoeck R, De Clercq E, Balzarini J. Bicyclic nucleoside inhibitors of varicella-zoster virus: 5'-chloro and 3'-chloro derivatives. Nucleosides, Nucleotides & Nucleic Acids. 22: 931-3. PMID 14565314 DOI: 10.1081/NCN-120022688 |
0.304 |
|
| 2003 |
Carangio A, McGuigan C, Andrei G, Snoeck R, De Clercq E, Balzarini J. Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): Pd-catalysed synthesis of 5-aryl derivatives and their biological evaluation. Antiviral Chemistry & Chemotherapy. 12: 187-97. PMID 12959327 DOI: 10.1177/095632020101200306 |
0.305 |
|
| 2002 |
Harris SA, McGuigan C, Andrei G, Snoeck R, De Clercq E, Balzarini J. Synthesis and antiviral evaluation of phosphoramidate derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine. Antiviral Chemistry & Chemotherapy. 12: 293-300. PMID 11900348 DOI: 10.1177/095632020101200504 |
0.332 |
|
| 2001 |
Brancale A, Srinivasan S, McGuigan C, Andrei G, Snoeck R, De Clercq E, Balzarini J. Synthesis and anti-varicella-zoster virus activity of some novel bicyclic nucleoside inhibitors: effect of enhanced aqueous solubility. Antiviral Chemistry & Chemotherapy. 11: 383-93. PMID 11227996 DOI: 10.1177/095632020001100605 |
0.314 |
|
| 2001 |
McGuigan C, Pathirana RN, Jones G, Andrei G, Snoeck R, De Clercq E, Balzarini J. Anti-varicella-zoster virus bicyclic nucleosides: replacement of furo by pyrro base reduces antiviral potency. Antiviral Chemistry & Chemotherapy. 11: 343-8. PMID 11142633 DOI: 10.1177/095632020001100505 |
0.31 |
|
| 2000 |
McGuigan C, Bidois L, Hiouni A, Ballatore C, De Clercq E, Balzarini J. Phosphoramidate derivatives of stavudine as inhibitors of HIV: unnatural amino acids may substitute for alanine. Antiviral Chemistry & Chemotherapy. 11: 111-6. PMID 10819435 DOI: 10.1177/095632020001100203 |
0.375 |
|
| 1999 |
McGuigan C, Yarnold CJ, Jones G, Velázquez S, Barucki H, Brancale A, Andrei G, Snoeck R, De Clercq E, Balzarini J. Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base. Journal of Medicinal Chemistry. 42: 4479-84. PMID 10579812 DOI: 10.1021/JM990346O |
0.331 |
|
| 1999 |
McGuigan C, Tsang HW, Sutton PW, De Clercq E, Balzarini J. Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency. Antiviral Chemistry & Chemotherapy. 9: 109-15. PMID 9875382 DOI: 10.1177/095632029800900202 |
0.348 |
|
| 1999 |
McGuigan C, Cahard D, Ballatore C, Siddiqui A, De Clercq E, Balzarini J. Lactate cannot substitute for alanine in d4T-based anti-HIV nucleotide prodrugs--despite efficient esterase-mediated hydrolysis. Bioorganic & Medicinal Chemistry Letters. 8: 2949-54. PMID 9873653 DOI: 10.1016/S0960-894X(98)00530-7 |
0.359 |
|
| 1999 |
McGuigan C, Sutton PW, Cahard D, Turner K, O'Leary G, Wang Y, Gumbleton M, De Clercq E, Balzarini J. Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T). Antiviral Chemistry & Chemotherapy. 9: 473-9. PMID 9865385 DOI: 10.1177/095632029800900603 |
0.336 |
|
| 1998 |
Balzarini J, Cahard D, Wedgwood O, Salgado A, Velázquez S, Yarnold CJ, De Clercq E, McGuigan C, Thormar H. Marked inhibitory activity of masked aryloxy aminoacyl phosphoramidate derivatives of dideoxynucleoside analogues against visna virus infection. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association. 17: 296-302. PMID 9525429 DOI: 10.1097/00042560-199804010-00002 |
0.35 |
|
| 1997 |
McGuigan C, Tsang HW, Cahard D, Turner K, Velazquez S, Salgado A, Bidois L, Naesens L, De Clercq E, Balzarini J. Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation. Antiviral Research. 35: 195-204. PMID 9298759 DOI: 10.1016/S0166-3542(97)00029-6 |
0.406 |
|
| 1997 |
Naesens L, Cahard D, Salgado A, Bidois L, De Clercq E, McGuigan C, Balzarini J. Anti-HIV activity and metabolism of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety Antiviral Research. 34: A54. DOI: 10.1016/S0166-3542(97)83180-4 |
0.321 |
|
| 1997 |
Naesens L, Cahard D, Salgado A, Bidois L, De Clercq E, McGuigan C, Balzarini J. Metabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety Clinical Biochemistry. 30: 271. DOI: 10.1016/S0009-9120(97)87750-8 |
0.321 |
|
| 1996 |
McGuigan C, Salgado A, Yarnold C, Harries T, De Clercq E, Balzarini J. Novel Nucleoside Phosphoramidates as Inhibitors of HIV: Studies on the Stereochemical Requirements of the Phosphoramidate Amino Acid Antiviral Chemistry and Chemotherapy. 7: 184-188. DOI: 10.1177/095632029600700402 |
0.411 |
|
| 1996 |
McGuigan C, Cahard D, Salgado A, De Clercq E, Balzarini J. Phosphoramidates as Potent Prodrugs of anti-HIV Nucleotides: Studies in the Amino Region Antiviral Chemistry and Chemotherapy. 7: 31-36. DOI: 10.1177/095632029600700106 |
0.35 |
|
| 1996 |
McGuigan C, Turner S, Mahmood N, Hay AJ. A rapid synthesis of some 5′-amino- nucleosides and nucleotides as potential antiviral compounds Bioorganic & Medicinal Chemistry Letters. 6: 2445-2448. DOI: 10.1016/0960-894X(96)00446-5 |
0.308 |
|
| 1993 |
McGuigan C, Pathirana RN, Choi SS, Kinchington D, O'Connor TJ. Phosphoramidate Derivatives of AZT as Inhibitors of HIV: Studies on the Carboxyl Terminus Antiviral Chemistry and Chemotherapy. 4: 97-101. DOI: 10.1177/095632029300400204 |
0.385 |
|
| 1993 |
Mcguigan C, Narashiman P. Synthesis of Some Amino Acid Linked Nitrogen Mustard Derivatives Synthesis. 1993: 311-314. DOI: 10.1055/S-1993-25855 |
0.346 |
|
| 1993 |
McGuigan C, Sheeka HM, Mahmood N, Hay A. Phosphate derivatives of d4T as inhibitors of HIV Bioorganic and Medicinal Chemistry Letters. 3: 1203-1206. DOI: 10.1016/S0960-894X(00)80315-7 |
0.311 |
|
| 1991 |
McGuigan C, Devine KG, O'Connor TJ, Kinchington D. Synthesis and anti-HIV activity of some haloalkyl phosphoramidate derivatives of 3'-azido-3'-deoxythymidine (AZT): potent activity of the trichloroethyl methoxyalaninyl compound. Antiviral Research. 15: 255-63. PMID 1888176 DOI: 10.1016/0166-3542(91)90071-x |
0.331 |
|
| 1991 |
Jones BCNM, McGuigan C, O'Connor TJ, Jeffries DJ, Kinchington D. Synthesis and anti-HIV Activity of Some Novel Phosphorodiamidate Derivatives of 3′-azido-3′-deoxythymidine (AZT) Antiviral Chemistry and Chemotherapy. 2: 35-39. DOI: 10.1177/095632029100200106 |
0.41 |
|
| 1990 |
McGuigan C, Devine KG, O'Connor TJ, Galpin SA, Jeffries DJ, Kinchington D. Synthesis and Evaluation of Some Novel Phosphoramidate Derivatives of 3′-Azido-3′-Deoxythymidine (AZT) as Anti-HIV Compounds Antiviral Chemistry and Chemotherapy. 1: 107-113. DOI: 10.1177/095632029000100205 |
0.407 |
|
| 1986 |
BUFFEL DK, MCGUIGAN C, ROBINS MJ. ChemInform Abstract: Nucleic Acid Related Compounds. Part 48. Photoaddition of Methanol to 9-(β-D- Ribofuranosyl)purine (Nebularine) to give Inhibitors of Adenosine Deaminase. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198602322 |
0.491 |
|
| 1985 |
Buffel DK, McGuigan C, Robins MJ. Nucleic acid related compounds. 48. Photoaddition of methanol to 9-(.beta.-D-ribofuranosyl) purine (nebularine) to give inhibitors of adenosine deaminase. The Journal of Organic Chemistry. 50: 2664-2667. DOI: 10.1021/Jo00215A014 |
0.426 |
|
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