Karen Bush, PhD - Publications

Affiliations: 
Indiana University, Bloomington, Bloomington, IN, United States 
Area:
Antibiotic resistance, beta-lactamases
Website:
https://biology.indiana.edu/about/faculty/bush-karen.html

151 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bush K. Classification for β-Lactamases: Historical Perspectives. Expert Review of Anti-Infective Therapy. PMID 36951174 DOI: 10.1080/14787210.2023.2194633  0.301
2022 Zhang Q, Neidig N, Chu TY, Divoky C, Carpenter J, Lee-Hsiao C, Threatt H, Sultana R, Bush K. In vitro antibacterial activity of cefiderocol against recent multidrug-resistant carbapenem-nonsusceptible Enterobacterales isolates. Diagnostic Microbiology and Infectious Disease. 103: 115651. PMID 35228130 DOI: 10.1016/j.diagmicrobio.2022.115651  0.378
2021 Das S, Bush K. Success and Challenges Associated with Large Scale Collaborative Surveillance for Carbapenemase Genes in Gram Negative Bacteria. Antimicrobial Agents and Chemotherapy. aac0229921. PMID 34930024 DOI: 10.1128/aac.02299-21  0.302
2020 Theuretzbacher U, Bush K, Harbarth S, Paul M, Rex JH, Tacconelli E, Thwaites GE. Critical analysis of antibacterial agents in clinical development. Nature Reviews. Microbiology. PMID 32152509 DOI: 10.1038/S41579-020-0340-0  0.446
2020 Bush K, Bradford PA. Epidemiology of β-Lactamase-Producing Pathogens. Clinical Microbiology Reviews. 33. PMID 32102899 DOI: 10.1128/Cmr.00047-19  0.423
2019 Carpenter J, Neidig N, Campbell A, Thornsberry T, Truex T, Fortney T, Zhang Y, Bush K. Activity of imipenem/relebactam against carbapenemase-producing Enterobacteriaceae with high colistin resistance. The Journal of Antimicrobial Chemotherapy. PMID 31430370 DOI: 10.1093/Jac/Dkz354  0.464
2019 Bush K, Bradford PA. Publisher Correction: Interplay between β-lactamases and new β-lactamase inhibitors. Nature Reviews. Microbiology. PMID 31040389 DOI: 10.1038/S41579-019-0206-5  0.312
2019 Bush K, Bradford PA. Interplay between β-lactamases and new β-lactamase inhibitors. Nature Reviews. Microbiology. PMID 30837684 DOI: 10.1038/S41579-019-0159-8  0.429
2018 Bush K. Past and Present Perspectives on β-Lactamases. Antimicrobial Agents and Chemotherapy. PMID 30061284 DOI: 10.1128/Aac.01076-18  0.442
2018 Hemarajata P, Amick T, Yang S, Gregson A, Holzmeyer C, Bush K, Humphries RM. Selection of hyperproduction of AmpC and SME-1 in a carbapenem-resistant Serratia marcescens isolate during antibiotic therapy. The Journal of Antimicrobial Chemotherapy. 73: 1256-1262. PMID 29471486 DOI: 10.1093/Jac/Dky028  0.438
2018 Bush K. Game Changers: New β-Lactamase Inhibitor Combinations Targeting Antibiotic Resistance in Gram-Negative Bacteria. Acs Infectious Diseases. 4: 84-87. PMID 29232103 DOI: 10.1021/Acsinfecdis.7B00243  0.494
2018 Yang S, Hemarajata P, Shevy L, Maciariello M, Culbreath K, Bush K, Humphries R. Unusual carbapenem resistant but ceftriaxone and cefepime susceptible isolated from a blood culture: Case report and whole-genome sequencing investigation. Idcases. 11: 9-11. PMID 29204354 DOI: 10.1016/J.Idcr.2017.11.007  0.37
2017 Zhang Y, Kashikar A, Bush K. In vitro activity of plazomicin against β-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE). The Journal of Antimicrobial Chemotherapy. 72: 2792-2795. PMID 29091224 DOI: 10.1093/Jac/Dkx261  0.426
2017 Zhang Y, Kashikar A, Brown CA, Denys G, Bush K. Unusual Escherichia coli PBP 3 Insertion Sequence Identified from a Collection of Carbapenem-Resistant Enterobacteriaceae Tested with a Combination of Ceftazidime-, Ceftaroline-, or Aztreonam-Avibactam. Antimicrobial Agents and Chemotherapy. 61. PMID 28559260 DOI: 10.1128/Aac.00389-17  0.406
2017 Bush K, Page MGP. What we may expect from novel antibacterial agents in the pipeline with respect to resistance and pharmacodynamic principles. Journal of Pharmacokinetics and Pharmacodynamics. 44: 113-132. PMID 28161807 DOI: 10.1007/S10928-017-9506-4  0.443
2016 Kao C, Lin X, Yi G, Zhang Y, Rowe-Magnus DA, Bush K. Cathelicidin Antimicrobial Peptides with Reduced Activation of Toll-Like Receptor Signaling Have Potent Bactericidal Activity against Colistin-Resistant Bacteria. Mbio. 7. PMID 27651360 DOI: 10.1128/Mbio.01418-16  0.343
2016 Zhang Y, Lin X, Bush K. In vitro susceptibility of β-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE) to eravacycline. The Journal of Antibiotics. 69: 600-4. PMID 27353166 DOI: 10.1038/Ja.2016.73  0.492
2016 Bush K, Bradford PA. β-Lactams and β-Lactamase Inhibitors: An Overview. Cold Spring Harbor Perspectives in Medicine. 6. PMID 27329032 DOI: 10.1101/Cshperspect.A025247  0.435
2016 Jacoby GA, Bonomo RA, Bradford PA, Bush K, Doi Y, Feldgarden M, Haft D, Klimke W, Nordmann P, Palzkill T, Poirel L, Prasad A, Rossolini GM, Walsh T. Comment on: Resistance gene naming and numbering: is it a new gene or not? The Journal of Antimicrobial Chemotherapy. 71: 2677-8. PMID 27261266 DOI: 10.1093/Jac/Dkw204  0.306
2016 Bush K. Overcoming β-lactam resistance in Gram-negative pathogens. Future Medicinal Chemistry. 8: 921-4. PMID 27228233 DOI: 10.4155/Fmc-2016-0076  0.448
2015 Bush K. Investigational Agents for the Treatment of Gram-Negative Bacterial Infections: A Reality Check. Acs Infectious Diseases. 1: 509-11. PMID 27623407 DOI: 10.1021/Acsinfecdis.5B00100  0.453
2015 Bush K. A resurgence of β-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens. International Journal of Antimicrobial Agents. 46: 483-93. PMID 26498989 DOI: 10.1016/J.Ijantimicag.2015.08.011  0.474
2015 Bush K. Antibiotics: Synergistic MRSA combinations. Nature Chemical Biology. 11: 832-3. PMID 26485079 DOI: 10.1038/Nchembio.1935  0.42
2015 Li H, Estabrook M, Jacoby GA, Nichols WW, Testa RT, Bush K. In vitro susceptibility of characterized β-lactamase-producing strains tested with avibactam combinations. Antimicrobial Agents and Chemotherapy. 59: 1789-93. PMID 25534728 DOI: 10.1128/Aac.04191-14  0.419
2014 Grant EB, Foleno BD, Goldschmidt R, Hilliard JJ, Lin SC, Morrow B, Paget SD, Weidner-Wells MA, Xu X, Xu X, Murray WV, Bush K, Macielag MJ. 7-(4-Alkylidenylpiperidinyl)-quinolone bacterial topoisomerase inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 5502-6. PMID 25455493 DOI: 10.1016/j.bmcl.2014.10.014  0.318
2014 Page MG, Bush K. Discovery and development of new antibacterial agents targeting Gram-negative bacteria in the era of pandrug resistance: is the future promising? Current Opinion in Pharmacology. 18: 91-7. PMID 25277839 DOI: 10.1016/J.Coph.2014.09.008  0.457
2014 Estabrook M, Bussell B, Clugston SL, Bush K. In vitro activity of ceftolozane-tazobactam as determined by broth dilution and agar diffusion assays against recent U.S. Escherichia coli isolates from 2010 to 2011 carrying CTX-M-type extended-spectrum β-lactamases. Journal of Clinical Microbiology. 52: 4049-52. PMID 25143578 DOI: 10.1128/Jcm.02357-14  0.352
2014 Perez F, Arias CA, Bush K, Drusano GL, Lolans K, Munoz-Price LS, Nicolau DP, Queenan AM, Rice LB, Segreti J, Shlaes DM, Weinstein RA, Bonomo RA. In memoriam: John P. Quinn, MD. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 58: 748-50. PMID 24336826 DOI: 10.1093/Cid/Cit801  0.442
2014 Pucci MJ, Page MGP, Bush K. Cautious optimism for the antibacterial pipeline: Despite dire warnings, there is resurgent effort to develop novel antibiotics, with several dozen candidate drugs already entered into clinical trials Microbe. 9: 147-152. DOI: 10.1128/Microbe.9.147.1  0.388
2013 Bush K. Carbapenemases: Partners in crime. Journal of Global Antimicrobial Resistance. 1: 7-16. PMID 27873609 DOI: 10.1016/J.Jgar.2013.01.005  0.487
2013 Pucci MJ, Bush K. Investigational antimicrobial agents of 2013. Clinical Microbiology Reviews. 26: 792-821. PMID 24092856 DOI: 10.1128/Cmr.00033-13  0.422
2013 Bush K. The ABCD's of β-lactamase nomenclature. Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy. 19: 549-59. PMID 23828655 DOI: 10.1007/S10156-013-0640-7  0.388
2013 Hayakawa K, Gattu S, Marchaim D, Bhargava A, Palla M, Alshabani K, Gudur UM, Pulluru H, Bathina P, Sundaragiri PR, Sarkar M, Kakarlapudi H, Ramasamy B, Nanjireddy P, Mohin S, ... ... Bush K, et al. Epidemiology and risk factors for isolation of Escherichia coli producing CTX-M-type extended-spectrum β-lactamase in a large U.S. Medical Center. Antimicrobial Agents and Chemotherapy. 57: 4010-8. PMID 23752516 DOI: 10.1128/Aac.02516-12  0.308
2013 Bush K. Introduction to Antimicrobial Therapeutics Reviews: the bacterial cell wall as an antimicrobial target. Annals of the New York Academy of Sciences. 1277: v-vii. PMID 23346862 DOI: 10.1111/Nyas.12025  0.312
2013 Bush K. Proliferation and significance of clinically relevant β-lactamases. Annals of the New York Academy of Sciences. 1277: 84-90. PMID 23346859 DOI: 10.1111/Nyas.12023  0.453
2013 Bush K, Pannell M, Lock JL, Queenan AM, Jorgensen JH, Lee RM, Lewis JS, Jarrett D. Detection systems for carbapenemase gene identification should include the SME serine carbapenemase. International Journal of Antimicrobial Agents. 41: 1-4. PMID 23219246 DOI: 10.1016/J.Ijantimicag.2012.08.008  0.441
2012 Bush K. Antimicrobial agents targeting bacterial cell walls and cell membranes. Revue Scientifique Et Technique (International Office of Epizootics). 31: 43-56. PMID 22849267  0.319
2012 Bush K. Improving known classes of antibiotics: an optimistic approach for the future. Current Opinion in Pharmacology. 12: 527-34. PMID 22748801 DOI: 10.1016/J.Coph.2012.06.003  0.45
2012 Pulcini C, Bush K, Craig WA, Frimodt-Møller N, Grayson ML, Mouton JW, Turnidge J, Harbarth S, Gyssens IC. Forgotten antibiotics: an inventory in Europe, the United States, Canada, and Australia. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 54: 268-74. PMID 22198992 DOI: 10.1093/Cid/Cir838  0.421
2011 Bush K. Introduction to Antimicrobial Therapeutics Reviews: antibiotics that target the ribosome. Annals of the New York Academy of Sciences. 1241: vii-ix. PMID 22191533 DOI: 10.1111/J.1749-6632.2011.06367.X  0.324
2011 Bush K, Courvalin P, Dantas G, Davies J, Eisenstein B, Huovinen P, Jacoby GA, Kishony R, Kreiswirth BN, Kutter E, Lerner SA, Levy S, Lewis K, Lomovskaya O, Miller JH, et al. Tackling antibiotic resistance. Nature Reviews. Microbiology. 9: 894-6. PMID 22048738 DOI: 10.1038/Nrmicro2693  0.413
2011 Bush K, Pucci MJ. New antimicrobial agents on the horizon. Biochemical Pharmacology. 82: 1528-39. PMID 21798250 DOI: 10.1016/J.Bcp.2011.07.077  0.427
2011 Bush K, Fisher JF. Epidemiological expansion, structural studies, and clinical challenges of new β-lactamases from gram-negative bacteria. Annual Review of Microbiology. 65: 455-78. PMID 21740228 DOI: 10.1146/Annurev-Micro-090110-102911  0.446
2010 Bush K. The coming of age of antibiotics: discovery and therapeutic value. Annals of the New York Academy of Sciences. 1213: 1-4. PMID 21175674 DOI: 10.1111/J.1749-6632.2010.05872.X  0.359
2010 Bush K. Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae. Current Opinion in Microbiology. 13: 558-64. PMID 20920882 DOI: 10.1016/J.Mib.2010.09.006  0.459
2010 Bush K, Macielag MJ. New β-lactam antibiotics and β-lactamase inhibitors. Expert Opinion On Therapeutic Patents. 20: 1277-93. PMID 20839927 DOI: 10.1517/13543776.2010.515588  0.455
2010 Bush K. Bench-to-bedside review: The role of beta-lactamases in antibiotic-resistant Gram-negative infections. Critical Care (London, England). 14: 224. PMID 20594363 DOI: 10.1186/Cc8892  0.506
2010 Amsler K, Santoro C, Foleno B, Bush K, Flamm R. Comparison of broth microdilution, agar dilution, and Etest for susceptibility testing of doripenem against gram-negative and gram-positive pathogens. Journal of Clinical Microbiology. 48: 3353-7. PMID 20592149 DOI: 10.1128/Jcm.00494-10  0.356
2010 Roll DM, Yang Y, Wildey MJ, Bush K, Lee MD. Inhibition of metallo-beta-lactamases by pyridine monothiocarboxylic acid analogs. The Journal of Antibiotics. 63: 255-7. PMID 20224603 DOI: 10.1038/Ja.2010.20  0.496
2010 Morrow BJ, He W, Amsler KM, Foleno BD, Macielag MJ, Lynch AS, Bush K. In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. Antimicrobial Agents and Chemotherapy. 54: 1955-64. PMID 20176911 DOI: 10.1128/AAC.01374-09  0.303
2010 Bush K, Jacoby GA. Updated functional classification of beta-lactamases. Antimicrobial Agents and Chemotherapy. 54: 969-76. PMID 19995920 DOI: 10.1128/Aac.01009-09  0.418
2010 Shang W, Davies TA, Flamm RK, Bush K. Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates. Antimicrobial Agents and Chemotherapy. 54: 956-9. PMID 19949055 DOI: 10.1128/AAC.01024-09  0.307
2009 Baum EZ, Crespo-Carbone SM, Morrow BJ, Davies TA, Foleno BD, He W, Queenan AM, Bush K. Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 53: 2785-90. PMID 19433554 DOI: 10.1128/Aac.00018-09  0.354
2008 Abbanat D, Morrow B, Bush K. New agents in development for the treatment of bacterial infections. Current Opinion in Pharmacology. 8: 582-92. PMID 18761107 DOI: 10.1016/j.coph.2008.08.001  0.344
2008 Davies TA, Yee YC, Bush K, Sahm D, Evangelista A, Goldschmidt R. Effects of the 7-valent pneumococcal conjugate vaccine on U.S. levofloxacin-resistant Streptococcus pneumoniae. Microbial Drug Resistance (Larchmont, N.Y.). 14: 187-96. PMID 18707553 DOI: 10.1089/Mdr.2008.0805  0.311
2008 Bush K. Extended-spectrum beta-lactamases in North America, 1987-2006. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. 14: 134-43. PMID 18154537 DOI: 10.1111/j.1469-0691.2007.01848.x  0.305
2008 Yigit H, Queenan AM, Anderson GJ, Domenech-Sanchez A, Biddle JW, Steward CD, Alberti S, Bush K, Tenover FC. Novel carbapenem-hydrolyzing β-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae (Antimicrobial Agents and Chemotherapy (2001) 45, 4, (1151-1161)) Antimicrobial Agents and Chemotherapy. 52: 809. DOI: 10.1128/Aac.01445-07  0.453
2007 Queenan AM, Bush K. Carbapenemases: the versatile beta-lactamases. Clinical Microbiology Reviews. 20: 440-58, table of con. PMID 17630334 DOI: 10.1128/Cmr.00001-07  0.317
2007 Davies TA, Page MG, Shang W, Andrew T, Kania M, Bush K. Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy. 51: 2621-4. PMID 17470659 DOI: 10.1128/AAC.00029-07  0.303
2007 Bush K, Heep M, Macielag MJ, Noel GJ. Anti-MRSA beta-lactams in development, with a focus on ceftobiprole: the first anti-MRSA beta-lactam to demonstrate clinical efficacy. Expert Opinion On Investigational Drugs. 16: 419-29. PMID 17371191 DOI: 10.1517/13543784.16.4.419   0.308
2007 Davies T, Sahm D, Flamm R, Bush K. P2026 Activity of ceftobiprole against Pseudomonas aeruginosa clinical isolates from Europe collected in 2005–2006 International Journal of Antimicrobial Agents. 29. DOI: 10.1016/S0924-8579(07)71865-4  0.318
2007 Davies T, Sahm D, Flamm R, Bush K. P710 Baseline activity of ceftobiprole against methicillin-susceptible and -resistant staphylococcal clinical isolates from Europe collected in 2005–2006 International Journal of Antimicrobial Agents. 29: S172. DOI: 10.1016/S0924-8579(07)70551-4  0.397
2006 Queenan AM, Shang W, Schreckenberger P, Lolans K, Bush K, Quinn J. SME-3, a novel member of the Serratia marcescens SME family of carbapenem-hydrolyzing beta-lactamases. Antimicrobial Agents and Chemotherapy. 50: 3485-7. PMID 17005839 DOI: 10.1128/Aac.00363-06  0.319
2006 Fakioglu E, Queenan AM, Bush K, Jenkins SG, Herold BC. Amp C beta-lactamase-producing Escherichia coli in neonatal meningitis: diagnostic and therapeutic challenge. Journal of Perinatology : Official Journal of the California Perinatal Association. 26: 515-7. PMID 16871223 DOI: 10.1038/Sj.Jp.7211550  0.401
2006 Davies TA, Shang W, Bush K. Activities of ceftobiprole and other beta-lactams against Streptococcus pneumoniae clinical isolates from the United States with defined substitutions in penicillin-binding proteins PBP 1a, PBP 2b, and PBP 2x. Antimicrobial Agents and Chemotherapy. 50: 2530-2. PMID 16801437 DOI: 10.1128/AAC.00238-06  0.325
2006 Davies TA, Yee YC, Goldschmidt R, Bush K, Sahm DF, Evangelista A. Infrequent occurrence of single mutations in topoisomerase IV and DNA gyrase genes among US levofloxacin-susceptible clinical isolates of Streptococcus pneumoniae from nine institutions (1999-2003). The Journal of Antimicrobial Chemotherapy. 57: 437-42. PMID 16431861 DOI: 10.1093/Jac/Dki487  0.311
2006 Robicsek A, Strahilevitz J, Jacoby GA, Macielag M, Abbanat D, Park CH, Bush K, Hooper DC. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nature Medicine. 12: 83-8. PMID 16369542 DOI: 10.1038/nm1347  0.342
2005 Frère JM, Galleni M, Bush K, Dideberg O. Is it necessary to change the classification of {beta}-lactamases? The Journal of Antimicrobial Chemotherapy. 55: 1051-3. PMID 15886262 DOI: 10.1093/Jac/Dki155  0.344
2005 Abbanat D, Webb G, Foleno B, Li Y, Macielag M, Montenegro D, Wira E, Bush K. In vitro activities of novel 2-fluoro-naphthyridine-containing ketolides. Antimicrobial Agents and Chemotherapy. 49: 309-15. PMID 15616310 DOI: 10.1128/AAC.49.1.309-315.2005  0.313
2004 Bush K, Macielag M, Weidner-Wells M. Taking inventory: antibacterial agents currently at or beyond phase 1. Current Opinion in Microbiology. 7: 466-76. PMID 15451501 DOI: 10.1016/j.mib.2004.08.013  0.341
2004 Queenan AM, Foleno B, Gownley C, Wira E, Bush K. Effects of inoculum and beta-lactamase activity in AmpC- and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae clinical isolates tested by using NCCLS ESBL methodology. Journal of Clinical Microbiology. 42: 269-75. PMID 14715764 DOI: 10.1128/Jcm.42.1.269-275.2004  0.348
2003 Yigit H, Queenan AM, Rasheed JK, Biddle JW, Domenech-Sanchez A, Alberti S, Bush K, Tenover FC. Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2. Antimicrobial Agents and Chemotherapy. 47: 3881-9. PMID 14638498 DOI: 10.1128/Aac.47.12.3881-3889.2003  0.472
2003 Jumbe N, Louie A, Leary R, Liu W, Deziel MR, Tam VH, Bachhawat R, Freeman C, Kahn JB, Bush K, Dudley MN, Miller MH, Drusano GL. Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy. The Journal of Clinical Investigation. 112: 275-85. PMID 12865415 DOI: 10.1172/Jci16814  0.409
2003 Davies TA, Goldschmidt R, Pfleger S, Loeloff M, Bush K, Sahm DF, Evangelista A. Cross-resistance, relatedness and allele analysis of fluoroquinolone-resistant US clinical isolates of Streptococcus pneumoniae (1998-2000). The Journal of Antimicrobial Chemotherapy. 52: 168-75. PMID 12837740 DOI: 10.1093/Jac/Dkg309  0.404
2003 Materon IC, Queenan AM, Koehler TM, Bush K, Palzkill T. Biochemical characterization of beta-lactamases Bla1 and Bla2 from Bacillus anthracis. Antimicrobial Agents and Chemotherapy. 47: 2040-2. PMID 12760895 DOI: 10.1128/Aac.47.6.2040-2042.2003  0.348
2003 Abbanat D, Macielag M, Bush K. Novel antibacterial agents for the treatment of serious Gram-positive infections. Expert Opinion On Investigational Drugs. 12: 379-99. PMID 12605562 DOI: 10.1517/13543784.12.3.379  0.343
2002 Bush K. The impact of beta-lactamases on the development of novel antimicrobial agents. Current Opinion in Investigational Drugs (London, England : 2000). 3: 1284-90. PMID 12498001  0.335
2002 Rasheed JK, Anderson GJ, Queenan AM, Biddle JW, Oliver A, Jacoby GA, Bush K, Tenover FC. TEM-71, a novel plasmid-encoded, extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy. 46: 2000-3. PMID 12019125 DOI: 10.1128/Aac.46.6.2000-2003.2002  0.443
2002 Docquier JD, Pantanella F, Giuliani F, Thaller MC, Amicosante G, Galleni M, Frère JM, Bush K, Rossolini GM. CAU-1, a subclass B3 metallo-beta-lactamase of low substrate affinity encoded by an ortholog present in the Caulobacter crescentus chromosome. Antimicrobial Agents and Chemotherapy. 46: 1823-30. PMID 12019096 DOI: 10.1128/Aac.46.6.1823-1830.2002  0.421
2002 Davies TA, Evangelista A, Pfleger S, Bush K, Sahm DF, Goldschmidt R. Prevalence of single mutations in topoisomerase type II genes among levofloxacin-susceptible clinical strains of Streptococcus pneumoniae isolated in the United States in 1992 to 1996 and 1999 to 2000. Antimicrobial Agents and Chemotherapy. 46: 119-24. PMID 11751121 DOI: 10.1128/Aac.46.1.119-124.2002  0.318
2002 Wong-Beringer A, Hindler J, Loeloff M, Queenan AM, Lee N, Pegues DA, Quinn JP, Bush K. Molecular correlation for the treatment outcomes in bloodstream infections caused by Escherichia coli and Klebsiella pneumoniae with reduced susceptibility to ceftazidime. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 34: 135-46. PMID 11740699 DOI: 10.1086/324742  0.399
2001 Queenan AM, Jenkins S, Bush K. Cloning and biochemical characterization of FOX-5, an AmpC-type plasmid-encoded beta-lactamase from a New York City Klebsiella pneumoniae clinical isolate. Antimicrobial Agents and Chemotherapy. 45: 3189-94. PMID 11600376 DOI: 10.1128/Aac.45.11.3189-3194.2001  0.447
2001 Baum EZ, Montenegro DA, Licata L, Turchi I, Webb GC, Foleno BD, Bush K. Identification and Characterization of New Inhibitors of the Escherichia coli MurA Enzyme Antimicrobial Agents and Chemotherapy. 45: 3182-3188. PMID 11600375 DOI: 10.1128/Aac.45.11.3182-3188.2001  0.426
2001 Bush K. New beta-lactamases in gram-negative bacteria: diversity and impact on the selection of antimicrobial therapy. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 32: 1085-9. PMID 11264037 DOI: 10.1086/319610  0.468
2001 Yigit H, Queenan AM, Anderson GJ, Domenech-Sanchez A, Biddle JW, Steward CD, Alberti S, Bush K, Tenover FC. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy. 45: 1151-61. PMID 11257029 DOI: 10.1128/Aac.45.4.1151-1161.2001  0.48
2000 Urban C, Mariano N, Rahman N, Queenan AM, Montenegro D, Bush K, Rahal JJ. Detection of multiresistant ceftazidime-susceptible Klebsiella pneumoniae isolates lacking TEM-26 after class restriction of cephalosporins. Microbial Drug Resistance (Larchmont, N.Y.). 6: 297-303. PMID 11272258 DOI: 10.1089/Mdr.2000.6.297  0.47
2000 Queenan AM, Torres-Viera C, Gold HS, Carmeli Y, Eliopoulos GM, Moellering RC, Quinn JP, Hindler J, Medeiros AA, Bush K. SME-type carbapenem-hydrolyzing class A beta-lactamases from geographically diverse Serratia marcescens strains. Antimicrobial Agents and Chemotherapy. 44: 3035-9. PMID 11036019 DOI: 10.1128/Aac.44.11.3035-3039.2000  0.457
2000 Grant EB, Guiadeen D, Baum EZ, Foleno BD, Jin H, Montenegro DA, Nelson EA, Bush K, Hlasta DJ. The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors. Bioorganic & Medicinal Chemistry Letters. 10: 2179-82. PMID 11012024 DOI: 10.1016/S0960-894X(00)00444-3  0.398
2000 Fogarty C, Goldschmidt R, Bush K. Bacteremic pneumonia due to multidrug-resistant pneumococci in 3 patients treated unsuccessfully with azithromycin and successfully with levofloxacin. Clinical Infectious Diseases. 31: 613-615. PMID 10987733 DOI: 10.1086/313976  0.396
2000 Bush K, Macielag M. New approaches in the treatment of bacterial infections Current Opinion in Chemical Biology. 4: 433-439. PMID 10959772 DOI: 10.1016/S1367-5931(00)00106-X  0.328
1999 Yang Y, Testa RT, Bhachech N, Rasmussen BA, Bush K. Biochemical characterization of novel tetrahydrofuranyl 1beta-methylcarbapenems: stability to hydrolysis by renal dehydropeptidases and bacterial beta-lactamases, binding to penicillin binding proteins, and permeability properties. Antimicrobial Agents and Chemotherapy. 43: 2904-9. PMID 10582880 DOI: 10.1128/Aac.43.12.2904  0.438
1999 Bush K. beta-Lactamases of increasing clinical importance. Current Pharmaceutical Design. 5: 839-45. PMID 10539991  0.323
1999 Ahmad M, Urban C, Mariano N, Bradford PA, Calcagni E, Projan SJ, Bush K, Rahal JJ. Clinical characteristics and molecular epidemiology associated with imipenem-resistant Klebsiella pneumoniae. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 29: 352-5. PMID 10476741 DOI: 10.1086/520214  0.438
1999 Hilliard JJ, Goldschmidt RM, Licata L, Baum EZ, Bush K. Multiple Mechanisms of Action for Inhibitors of Histidine Protein Kinases from Bacterial Two-Component Systems Antimicrobial Agents and Chemotherapy. 43: 1693-1699. PMID 10390224 DOI: 10.1128/Aac.43.7.1693  0.305
1999 Wiener J, Quinn JP, Bradford PA, Goering RV, Nathan C, Bush K, Weinstein RA. Multiple antibiotic-resistant Klebsiella and Escherichia coli in nursing homes. Jama. 281: 517-23. PMID 10022107 DOI: 10.1001/Jama.281.6.517  0.441
1998 Bush K, Miller GH. Bacterial enzymatic resistance: beta-lactamases and aminoglycoside-modifying enzymes. Current Opinion in Microbiology. 1: 509-15. PMID 10066532 DOI: 10.1016/S1369-5274(98)80082-9  0.442
1998 Bush K. Metallo-beta-lactamases: a class apart. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 27: S48-53. PMID 9710671  0.359
1998 Yang Y, Bhachech N, Bradford PA, Jett BD, Sahm DF, Bush K. Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 beta-lactamases from St. Louis, Missouri. Antimicrobial Agents and Chemotherapy. 42: 1671-6. PMID 9661002 DOI: 10.1128/Aac.42.7.1671  0.507
1998 Bush K, Mobashery S. How β-Lactamases Have Driven Pharmaceutical Drug Discovery Advances in Experimental Medicine and Biology. 456: 71-98. DOI: 10.1007/978-1-4615-4897-3_5  0.483
1997 Bush K. Antimicrobial agents. Current Opinion in Chemical Biology. 1: 169-75. PMID 9667849  0.337
1997 Concha NO, Rasmussen BA, Bush K, Herzberg O. Crystal structures of the cadmium- and mercury-substituted metallo-beta-lactamase from Bacteroides fragilis. Protein Science : a Publication of the Protein Society. 6: 2671-6. PMID 9416622 DOI: 10.1002/Pro.5560061225  0.34
1997 Bush K. The evolution of beta-lactamases. Ciba Foundation Symposium. 207: 152-63; discussion 1. PMID 9189640  0.356
1997 Fung-Tomc J, Bush K, Minassian B, Kolek B, Flamm R, Gradelski E, Bonner D. Antibacterial activity of BMS-180680, a new catechol-containing monobactam. Antimicrobial Agents and Chemotherapy. 41: 1010-6. PMID 9145861 DOI: 10.1128/Aac.41.5.1010  0.419
1997 Bradford PA, Urban C, Mariano N, Projan SJ, Rahal JJ, Bush K. Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein. Antimicrobial Agents and Chemotherapy. 41: 563-9. PMID 9055993 DOI: 10.1128/Aac.41.3.563  0.452
1997 Rasmussen BA, Bush K, Tally FP. Antimicrobial resistance in anaerobes. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 24: S110-20. PMID 8994790  0.371
1997 Lin YI, Bitha P, Li Z, Sakya SM, Strohmeyer TW, Lang SA, Yang Y, Bhachech N, Weiss WJ, Petersen PJ, Jacobus NV, Bush K, Testa RT. Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems Bioorganic and Medicinal Chemistry Letters. 7: 1811-1816. DOI: 10.1016/S0960-894X(97)00305-3  0.315
1997 Lin YI, Bitha P, Sakya SM, Strohmeyer TW, Li Z, Lee VJ, Lang SA, Yang Y, Bhachech N, Weiss WJ, Petersen PJ, Jacobus NV, Bush K, Testa RT, Tally FP. Synthesis and structure-activity relationships of novel THF 1β- methylcarbapenems Bioorganic and Medicinal Chemistry Letters. 7: 1671-1676. DOI: 10.1016/S0960-894X(97)00282-5  0.334
1996 Yang Y, Bush K. Biochemical characterization of the carbapenem-hydrolyzing beta-lactamase AsbM1 from Aeromonas sobria AER 14M: a member of a novel subgroup of metallo-beta-lactamases. Fems Microbiology Letters. 137: 193-200. PMID 8998985 DOI: 10.1111/J.1574-6968.1996.Tb08105.X  0.414
1996 Rasmussen BA, Bush K, Keeney D, Yang Y, Hare R, O'Gara C, Medeiros AA. Characterization of IMI-1 beta-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae. Antimicrobial Agents and Chemotherapy. 40: 2080-6. PMID 8878585 DOI: 10.1128/Aac.40.9.2080  0.472
1996 Concha NO, Rasmussen BA, Bush K, Herzberg O. Crystal structure of the wide-spectrum binuclear zinc beta-lactamase from Bacteroides fragilis. Structure (London, England : 1993). 4: 823-36. PMID 8805566 DOI: 10.1016/S0969-2126(96)00089-5  0.422
1996 Bush K. Is it important to identify extended-spectrum beta-lactamase-producing isolates? European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology. 15: 361-4. PMID 8793392  0.31
1996 Bradford PA, Jacobus NV, Bhachech N, Bush K. TEM-28 from an Escherichia coli clinical isolate is a member of the His-164 family of TEM-1 extended-spectrum beta-lactamases. Antimicrobial Agents and Chemotherapy. 40: 260-2. PMID 8787920 DOI: 10.1128/Aac.40.1.260  0.425
1996 Concha NO, Rasmussen BA, Bush K, Herzberg O. Crystal structure of the wide-spectrum binuclear zinc β-lactamase from Bacteroides fragilis Acta Crystallographica Section A. 52: 132-132. DOI: 10.1107/S0108767396093944  0.31
1996 Hedberg M, Bush K, Bradford PA, Bhachech N, Edlund C, Tunér K, Nord CE. The role of penicillin-binding proteins for β-lactam resistance in a β-lactamase producing bacteroides uniformis strain Anaerobe. 2: 111-115. DOI: 10.1006/Anae.1996.0014  0.355
1995 Bradford PA, Urban C, Jaiswal A, Mariano N, Rasmussen BA, Projan SJ, Rahal JJ, Bush K. SHV-7, a novel cefotaxime-hydrolyzing beta-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patients. Antimicrobial Agents and Chemotherapy. 39: 899-905. PMID 7785992 DOI: 10.1128/Aac.39.4.899  0.428
1995 Yang Y, Bhachech N, Bush K. Biochemical comparison of imipenem, meropenem and biapenem: permeability, binding to penicillin-binding proteins, and stability to hydrolysis by beta-lactamases. The Journal of Antimicrobial Chemotherapy. 35: 75-84. PMID 7768785 DOI: 10.1093/Jac/35.1.75  0.441
1994 Urban C, Meyer KS, Mariano N, Rahal JJ, Flamm R, Rasmussen BA, Bush K. Identification of TEM-26 beta-lactamase responsible for a major outbreak of ceftazidime-resistant Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy. 38: 392-5. PMID 8192474 DOI: 10.1128/Aac.38.2.392  0.479
1994 Bradford PA, Cherubin CE, Idemyor V, Rasmussen BA, Bush K. Multiply resistant Klebsiella pneumoniae strains from two Chicago hospitals: identification of the extended-spectrum TEM-12 and TEM-10 ceftazidime-hydrolyzing beta-lactamases in a single isolate. Antimicrobial Agents and Chemotherapy. 38: 761-6. PMID 8031043 DOI: 10.1128/Aac.38.4.761  0.46
1994 Gonzalez Leiza M, Perez-Diaz JC, Ayala J, Casellas JM, Martinez-Beltran J, Bush K, Baquero F. Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid-mediated beta-lactamase with two molecular variants. Antimicrobial Agents and Chemotherapy. 38: 2150-7. PMID 7811034  0.344
1994 Rasmussen BA, Yang Y, Jacobus N, Bush K. Contribution of enzymatic properties, cell permeability, and enzyme expression to microbiological activities of beta-lactams in three Bacteroides fragilis isolates that harbor a metallo-beta-lactamase gene. Antimicrobial Agents and Chemotherapy. 38: 2116-20. PMID 7811029 DOI: 10.1128/Aac.38.9.2116  0.477
1994 Rasmussen BA, Keeney D, Yang Y, Bush K. Cloning and expression of a cloxacillin-hydrolyzing enzyme and a cephalosporinase from Aeromonas sobria AER 14M in Escherichia coli: requirement for an E. coli chromosomal mutation for efficient expression of the class D enzyme. Antimicrobial Agents and Chemotherapy. 38: 2078-85. PMID 7811022 DOI: 10.1128/Aac.38.9.2078  0.421
1993 Bush K, Macalintal C, Rasmussen BA, Lee VJ, Yang Y. Kinetic interactions of tazobactam with β-lactamases from all major structural classes Antimicrobial Agents and Chemotherapy. 37: 851-858. PMID 8388201 DOI: 10.1128/Aac.37.4.851  0.379
1993 Rasmussen BA, Bush K, Tally FP. Antimicrobial resistance in Bacteroides. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 16: S390-400. PMID 8324154 DOI: 10.1093/Clinids/16.Supplement_4.S390  0.484
1993 Rasmussen BA, Bradford PA, Quinn JP, Wiener J, Weinstein RA, Bush K. Genetically diverse ceftazidime-resistant isolates from a single center: biochemical and genetic characterization of TEM-10 beta-lactamases encoded by different nucleotide sequences. Antimicrobial Agents and Chemotherapy. 37: 1989-92. PMID 8239618 DOI: 10.1128/Aac.37.9.1989  0.442
1992 Yang Y, Rasmussen BA, Bush K. Biochemical characterization of the metallo-beta-lactamase CcrA from Bacteroides fragilis TAL3636. Antimicrobial Agents and Chemotherapy. 36: 1155-7. PMID 1510410 DOI: 10.1128/Aac.36.5.1155  0.437
1992 Naumovski L, Quinn JP, Miyashiro D, Patel M, Bush K, Singer SB, Graves D, Palzkill T, Arvin AM. Outbreak of ceftazidime resistance due to a novel extended-spectrum beta-lactamase in isolates from cancer patients. Antimicrobial Agents and Chemotherapy. 36: 1991-6. PMID 1416892 DOI: 10.1128/AAC.36.9.1991  0.377
1991 Sowek JA, Singer SB, Ohringer S, Malley MF, Dougherty TJ, Gougoutas JZ, Bush K. Substitution of lysine at position 104 or 240 of TEM-1pTZ18R beta-lactamase enhances the effect of serine-164 substitution on hydrolysis or affinity for cephalosporins and the monobactam aztreonam. Biochemistry. 30: 3179-88. PMID 1901218 DOI: 10.1021/Bi00227A004  0.363
1991 Bush K, Flamm RK, Ohringer S, Singer SB, Summerill R, Bonner DP. Effect of clavulanic acid on activity of beta-lactam antibiotics in Serratia marcescens isolates producing both a TEM beta-lactamase and a chromosomal cephalosporinase. Antimicrobial Agents and Chemotherapy. 35: 2203-8. PMID 1803992  0.345
1989 Quinn JP, Miyashiro D, Sahm D, Flamm R, Bush K. Novel plasmid-mediated beta-lactamase (TEM-10) conferring selective resistance to ceftazidime and aztreonam in clinical isolates of Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy. 33: 1451-6. PMID 2684007 DOI: 10.1128/Aac.33.9.1451  0.497
1989 Bush K, Singer SB. Biochemical characteristics of extended broad spectrum beta-lactamases. Infection. 17: 429-33. PMID 2613337  0.314
1988 Bush K, Smith SA, Tanaka SK, Bonner DP. Inactivation of beta-lactamases from Enterobacter cloacae by monophosphams. The Journal of Antimicrobial Chemotherapy. 22: 801-9. PMID 3266620 DOI: 10.1093/jac/22.6.801  0.301
1988 Bush K. Beta-lactamase inhibitors from laboratory to clinic. Clinical Microbiology Reviews. 1: 109-23. PMID 3060240  0.382
1988 Bush K. Recent developments in beta-lactamase research and their implications for the future. Reviews of Infectious Diseases. 10: 681-90. PMID 3055169  0.33
1987 Bush K, Smith SA, Ohringer S, Tanaka SK, Bonner DP. Improved sensitivity in assays for binding of novel beta-lactam antibiotics to penicillin-binding proteins of Escherichia coli. Antimicrobial Agents and Chemotherapy. 31: 1271-3. PMID 3307621 DOI: 10.1128/Aac.31.8.1271  0.33
1987 Tanaka SK, Summerill RA, Minassian BF, Bush K, Visnic DA, Bonner DP, Sykes RB. In vitro evaluation of tigemonam, a novel oral monobactam. Antimicrobial Agents and Chemotherapy. 31: 219-25. PMID 3105448  0.353
1986 Joris B, De Meester F, Galleni M, Masson S, Dusart J, Frère JM, Van Beeumen J, Bush K, Sykes R. Properties of a class C beta-lactamase from Serratia marcescens. The Biochemical Journal. 239: 581-6. PMID 3548700 DOI: 10.1042/Bj2390581  0.436
1985 Bush K, Tanaka SK, Bonner DP, Sykes RB. Resistance caused by decreased penetration of beta-lactam antibiotics into Enterobacter cloacae. Antimicrobial Agents and Chemotherapy. 27: 555-60. PMID 3873900 DOI: 10.1128/Aac.27.4.555  0.465
1984 Bush K, Henry PR, Slusarchyk DS. Muraceins--muramyl peptides produced by Nocardia orientalis as angiotensin-converting enzyme inhibitors. I. Taxonomy, fermentation and biological properties. The Journal of Antibiotics. 37: 330-335. PMID 6327590 DOI: 10.7164/Antibiotics.37.330  0.301
1984 Bush K, Henry PR, Souser-Woehleke M, Trejo WH, Slusarchyk DS. Phenacein--an angiotensin-converting enzyme inhibitor produced by a streptomycete. I. Taxonomy, fermentation and biological properties. The Journal of Antibiotics. 37: 1308-1312. PMID 6096340 DOI: 10.7164/Antibiotics.37.1308  0.35
1983 Cooper R, Bush K, Principe PA, Trejo WH, Wells JS, Sykes RB. Two new monobactam antibiotics produced by a Flexibacter sp. I. Taxonomy, fermentation, isolation and biological properties. The Journal of Antibiotics. 36: 1252-7. PMID 6643274 DOI: 10.7164/Antibiotics.36.1252  0.43
1982 Bush K, Freudenberger JS, Sykes RB. Interaction of azthreonam and related monobactams with beta-lactamases from gram-negative bacteria. Antimicrobial Agents and Chemotherapy. 22: 414-20. PMID 6982680  0.304
1982 Sykes RB, Bonner DP, Bush K, Georgopapadakou NH. Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria. Antimicrobial Agents and Chemotherapy. 21: 85-92. PMID 6979307 DOI: 10.1128/Aac.21.1.85  0.428
1982 Wells JS, Trejo WH, Principe PA, Bush K, Georgopapadakou N, Bonner DP, Sykes RB. EM5400, a family of monobactam antibiotics produced by Agrobacterium radiobacter. I. Taxonomy, fermentation and biological properties. The Journal of Antibiotics. 35: 295-9. PMID 6978878 DOI: 10.7164/Antibiotics.35.295  0.436
1982 Wells JS, Trejo WH, Principe PA, Bush K, Georgopapadakou N, Bonner DP, Sykes RB. SQ 26,180, a novel monobactam. I Taxonomy, fermentation and biological properties. The Journal of Antibiotics. 35: 184-8. PMID 6978877 DOI: 10.7164/Antibiotics.35.184  0.478
1981 Sykes RB, Cimarusti CM, Bonner DP, Bush K, Floyd DM, Georgopapadakou NH, Koster WM, Liu WC, Parker WL, Principe PA, Rathnum ML, Slusarchyk WA, Trejo WH, Wells JS. Monocyclic beta-lactam antibiotics produced by bacteria. Nature. 291: 489-91. PMID 7015152 DOI: 10.1038/291489a0  0.329
1981 Sykes RB, Bonner DP, Bush K, Georgopapadakou NH, Wells JS. Monobactams--monocyclic beta-lactam antibiotics produced by bacteria. The Journal of Antimicrobial Chemotherapy. 8: 1-16. PMID 6976959 DOI: 10.1093/JAC/8.SUPPL_E.1  0.329
1981 SYKES RB, CIMARUSTI CM, BONNER DP, BUSH K, FLOYD DM, GEORGOPAPADAKOU NH, KOSTER WH, LIU WC, PARKER WL, PRINCIPE PA, RATHNUM ML, SLUSARCHYK WA, TREJO WH, WELLS JS. ChemInform Abstract: MONOCYCLIC β-LACTAM ANTIBIOTICS PRODUCED BY BACTERIA Chemischer Informationsdienst. 12. DOI: 10.1002/Chin.198139343  0.419
1980 Bush K, Bonner DP, Sykes RB. Izumenolide-a novel beta-lactamase inhibitor produced by Micromonospora. II. Biological properties. The Journal of Antibiotics. 33: 1262-9. PMID 6972939 DOI: 10.7164/Antibiotics.33.1262  0.438
1973 Bush K, Shiner VJ, Mahler HR. Deuterium isotope effects on initial rates of the liver alcohol dehydrogenase reaction. Biochemistry. 12: 4802-5. PMID 4359375 DOI: 10.1021/Bi00747A037  0.493
1972 Bush KJ, Sweeney BM. The Activity of Ribulose Diphosphate Carboxylase in Extracts of Gonyaulax polyedra in the Day and the Night Phases of the Circadian Rhythm of Photosynthesis. Plant Physiology. 50: 446-51. PMID 16658193 DOI: 10.1104/Pp.50.4.446  0.541
1971 Bush K, Mahler HR, Shiner VJ. Deuterium effects on binding of reduced coenzyme alcohol dehydrogenase isoenzyme EE. Science (New York, N.Y.). 172: 478-80. PMID 4323799 DOI: 10.1126/Science.172.3982.478  0.491
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