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Joel C. Watts - Publications

Affiliations: 
2003-2008 Centre for Research in Neurodegenerative Diseases University of Toronto, Toronto, ON, Canada 
 2008-2014 Institute for Neurodegenerative Diseases, Department of Neurology University of California, San Francisco, San Francisco, CA 
 2014- Tanz Centre for Research in Neurodegenerative Diseases, Department of Biochemistry University of Toronto, Toronto, ON, Canada 
Website:
http://biochemistry.utoronto.ca/person/joel-c-watts/
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67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Walsh DJ, Rees JR, Mehra S, Bourkas MEC, Kaczmarczyk L, Stuart E, Jackson WS, Watts JC, Supattapone S. Anti-prion drugs do not improve survival in knock-in models of inherited prion disease. Biorxiv : the Preprint Server For Biology. PMID 37808761 DOI: 10.1101/2023.09.28.559951  0.802
2023 Lau HHC, Martinez-Valbuena I, So RWL, Mehra S, Silver NRG, Mao A, Stuart E, Schmitt-Ulms C, Hyman BT, Ingelsson M, Kovacs GG, Watts JC. The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease. Acta Neuropathologica Communications. 11: 72. PMID 37138318 DOI: 10.1186/s40478-023-01570-5  0.618
2023 So RWL, Watts JC. α-Synuclein Conformational Strains as Drivers of Phenotypic Heterogeneity in Neurodegenerative Diseases. Journal of Molecular Biology. 168011. PMID 36792008 DOI: 10.1016/j.jmb.2023.168011  0.319
2023 Williams D, Yan BQ, Wang H, Negm L, Sackmann C, Verkuyl C, Rezai-Stevens V, Eid S, Vediya N, Sato C, Watts JC, Wille H, Schmitt-Ulms G. Somatostatin slows Aβ plaque deposition in aged APP mice by blocking Aβ aggregation. Scientific Reports. 13: 2337. PMID 36759538 DOI: 10.1038/s41598-023-29559-z  0.647
2022 Arshad H, Patel Z, Amano G, Li LY, Al-Azzawi ZAM, Supattapone S, Schmitt-Ulms G, Watts JC. A Single Protective Polymorphism in the Prion Protein Blocks Cross-Species Prion Replication in Cultured Cells. Journal of Neurochemistry. PMID 36511154 DOI: 10.1111/jnc.15739  0.817
2022 Arshad H, Watts JC. Genetically engineered cellular models of prion propagation. Cell and Tissue Research. PMID 35581386 DOI: 10.1007/s00441-022-03630-z  0.668
2021 Williams D, Mehrabian M, Arshad H, Eid S, Sackmann C, Zhao W, Wang X, Ghodrati F, Verkuyl CE, Watts JC, Schmitt-Ulms G. The cellular prion protein interacts with and promotes the activity of Na,K-ATPases. Plos One. 16: e0258682. PMID 34847154 DOI: 10.1371/journal.pone.0258682  0.763
2021 Arshad H, Patel Z, Mehrabian M, Bourkas MEC, Al-Azzawi ZAM, Schmitt-Ulms G, Watts JC. The aminoglycoside G418 hinders de novo prion infection in cultured cells. The Journal of Biological Chemistry. 101073. PMID 34390689 DOI: 10.1016/j.jbc.2021.101073  0.782
2021 Ruiz-Riquelme A, Mao A, Barghash MM, Lau HHC, Stuart E, Kovacs GG, Nilsson KPR, Fraser PE, Schmitt-Ulms G, Watts JC. Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice. Acta Neuropathologica Communications. 9: 83. PMID 33971978 DOI: 10.1186/s40478-021-01187-6  0.751
2021 Bélondrade M, Nicot S, Mayran C, Bruyere-Ostells L, Almela F, Di Bari MA, Levavasseur E, Watts JC, Fournier-Wirth C, Lehmann S, Haïk S, Nonno R, Bougard D. Sensitive protein misfolding cyclic amplification of sporadic Creutzfeldt-Jakob disease prions is strongly seed and substrate dependent. Scientific Reports. 11: 4058. PMID 33603091 DOI: 10.1038/s41598-021-83630-1  0.362
2020 Arshad H, Bourkas MEC, Watts JC. The utility of bank voles for studying prion disease. Progress in Molecular Biology and Translational Science. 175: 179-211. PMID 32958232 DOI: 10.1016/Bs.Pmbts.2020.08.009  0.811
2020 Burke CM, Mark KMK, Walsh DJ, Noble GP, Steele AD, Diack AB, Manson JC, Watts JC, Supattapone S. Identification of a homology-independent linchpin domain controlling mouse and bank vole prion protein conversion. Plos Pathogens. 16: e1008875. PMID 32898162 DOI: 10.1371/Journal.Ppat.1008875  0.697
2020 Lau HHC, Ingelsson M, Watts JC. The existence of Aβ strains and their potential for driving phenotypic heterogeneity in Alzheimer's disease. Acta Neuropathologica. PMID 32743745 DOI: 10.1007/S00401-020-02201-2  0.502
2020 Krance SH, Luke R, Shenouda M, Israwi AR, Colpitts SJ, Darwish L, Strauss M, Watts JC. Cellular Models for Discovering Prion Disease Therapeutics: Progress and Challenges. Journal of Neurochemistry. e14956. PMID 31943194 DOI: 10.1111/Jnc.14956  0.492
2019 Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, Stuart E, Menon S, Visanji NP, Meisl G, Faidi R, Marano MM, Schmitt-Ulms C, Wang Z, Fraser PE, ... ... Watts JC, et al. α-Synuclein strains target distinct brain regions and cell types. Nature Neuroscience. PMID 31792467 DOI: 10.1038/S41593-019-0541-X  0.728
2019 Watts JC. Calling α-synuclein a prion is scientifically justifiable. Acta Neuropathologica. PMID 31407029 DOI: 10.1007/S00401-019-02058-0  0.313
2019 Burke C, Walsh D, Steele A, Agrimi U, Di Bari MA, Watts JC, Supattapone S. Full restoration of specific infectivity and strain properties from pure mammalian prion protein. Plos Pathogens. 15: e1007662. PMID 30908557 DOI: 10.1371/Journal.Ppat.1007662  0.688
2019 Bourkas MEC, Arshad H, Al-Azzawi ZAM, Halgas O, Shikiya RA, Mehrabian M, Schmitt-Ulms G, Bartz JC, Watts JC. Engineering a murine cell line for the stable propagation of hamster prions. The Journal of Biological Chemistry. PMID 30705093 DOI: 10.1074/Jbc.Ra118.007135  0.802
2018 Ghodrati F, Mehrabian M, Williams D, Halgas O, Bourkas MEC, Watts JC, Pai EF, Schmitt-Ulms G. The prion protein is embedded in a molecular environment that modulates transforming growth factor β and integrin signaling. Scientific Reports. 8: 8654. PMID 29872131 DOI: 10.1038/S41598-018-26685-X  0.797
2018 Lau HHC, Lau A, Watts JC. Discriminating Strains of Self-Propagating Protein Aggregates Using a Conformational Stability Assay. Methods in Molecular Biology (Clifton, N.J.). 1777: 339-354. PMID 29744847 DOI: 10.1007/978-1-4939-7811-3_22  0.75
2018 Ruiz-Riquelme A, Lau HHC, Stuart E, Goczi AN, Wang Z, Schmitt-Ulms G, Watts JC. Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression. Acta Neuropathologica Communications. 6: 26. PMID 29615128 DOI: 10.1186/S40478-018-0529-X  0.677
2018 Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, et al. Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311311 DOI: 10.1073/Pnas.1714966115  0.751
2018 Watts JC, Bourkas MEC, Arshad H. The function of the cellular prion protein in health and disease. Acta Neuropathologica. 135: 159-178. PMID 29151170 DOI: 10.1007/S00401-017-1790-Y  0.814
2017 Wang X, Noroozian Z, Lynch M, Armstrong N, Schneider R, Liu M, Ghodrati F, Zhang AB, Yang YJ, Hall AC, Solarski M, Killackey SA, Watts JC. Strains of Pathological Protein Aggregates in Neurodegenerative Diseases. Discoveries (Craiova, Romania). 5: e78. PMID 32309596 DOI: 10.15190/d.2017.8  0.406
2017 Wang H, Muiznieks LD, Ghosh P, Williams D, Solarski M, Fang A, Ruiz-Riquelme A, Pomès R, Watts JC, Chakrabartty A, Wille H, Sharpe S, Schmitt-Ulms G. Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers. Elife. 6. PMID 28650319 DOI: 10.7554/Elife.28401  0.645
2017 Woerman AL, Watts JC, Aoyagi A, Giles K, Middleton LT, Prusiner SB. α-Synuclein: Multiple System Atrophy Prions. Cold Spring Harbor Perspectives in Medicine. PMID 28213437 DOI: 10.1101/Cshperspect.A024588  0.782
2017 Watts JC, Prusiner SB. β-Amyloid Prions and the Pathobiology of Alzheimer's Disease. Cold Spring Harbor Perspectives in Medicine. PMID 28193770 DOI: 10.1101/Cshperspect.A023507  0.603
2017 Watts JC, Prusiner SB. Experimental Models of Inherited PrP Prion Diseases. Cold Spring Harbor Perspectives in Medicine. PMID 28096244 DOI: 10.1101/Cshperspect.A027151  0.634
2017 Wang H, Muiznieks LD, Ghosh P, Williams D, Solarski M, Fang A, Ruiz-Riquelme A, Pomès R, Watts JC, Chakrabartty A, Wille H, Sharpe S, Schmitt-Ulms G. Author response: Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers Elife. DOI: 10.7554/Elife.28401.022  0.606
2016 Visanji NP, Brotchie JM, Kalia LV, Koprich JB, Tandon A, Watts JC, Lang AE. α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era. Trends in Neurosciences. PMID 27776749 DOI: 10.1016/J.Tins.2016.09.003  0.34
2016 Watts JC, Giles K, Saltzberg DJ, Dugger BN, Patel S, Oehler A, Bhardwaj S, Sali A, Prusiner SB. Guinea pig prion protein supports rapid propagation of bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease prions. Journal of Virology. PMID 27440899 DOI: 10.1128/Jvi.01106-16  0.628
2016 Watts JC, Giles K, Bourkas ME, Patel S, Oehler A, Gavidia M, Bhardwaj S, Lee J, Prusiner SB. Towards authentic transgenic mouse models of heritable PrP prion diseases. Acta Neuropathologica. PMID 27350609 DOI: 10.1007/S00401-016-1585-6  0.808
2015 Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, et al. Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proceedings of the National Academy of Sciences of the United States of America. 112: E5308-17. PMID 26324905 DOI: 10.1073/Pnas.1514475112  0.781
2015 Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, et al. Propagation of prions causing synucleinopathies in cultured cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E4949-58. PMID 26286986 DOI: 10.1073/Pnas.1513426112  0.801
2015 Watts JC, Giles K, Serban A, Patel S, Oehler A, Bhardwaj S, Guan S, Greicius MD, Miller BL, DeArmond SJ, Geschwind MD, Prusiner SB. Modulation of Creutzfeldt-Jakob disease prion propagation by the A224V mutation. Annals of Neurology. 78: 540-53. PMID 26094969 DOI: 10.1002/Ana.24463  0.552
2015 Wan W, Wille H, Stöhr J, Kendall A, Bian W, McDonald M, Tiggelaar S, Watts JC, Prusiner SB, Stubbs G. Structural studies of truncated forms of the prion protein PrP. Biophysical Journal. 108: 1548-54. PMID 25809267 DOI: 10.1016/J.Bpj.2015.01.008  0.561
2015 Watts JC, Giles K, Grillo SK, Lemus A, DeArmond SJ, Prusiner SB. Correction for Watts et al., Bioluminescence imaging of Aβ deposition in bigenic mouse models of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 112. PMID 25675539 DOI: 10.1073/Pnas.1502028112  0.48
2014 Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB. Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients. Proceedings of the National Academy of Sciences of the United States of America. 111: 10323-8. PMID 24982139 DOI: 10.1073/Pnas.1408900111  0.751
2014 Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB. Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 10329-34. PMID 24982137 DOI: 10.1073/Pnas.1408968111  0.774
2014 Watts JC, Prusiner SB. Mouse models for studying the formation and propagation of prions. The Journal of Biological Chemistry. 289: 19841-9. PMID 24860095 DOI: 10.1074/Jbc.R114.550707  0.624
2014 Watts JC, Giles K, Patel S, Oehler A, DeArmond SJ, Prusiner SB. Evidence that bank vole PrP is a universal acceptor for prions. Plos Pathogens. 10: e1003990. PMID 24699458 DOI: 10.1371/Journal.Ppat.1003990  0.615
2014 Mays CE, Coomaraswamy J, Watts JC, Yang J, Ko KW, Strome B, Mercer RC, Wohlgemuth SL, Schmitt-Ulms G, Westaway D. Endoproteolytic processing of the mammalian prion glycoprotein family. The Febs Journal. 281: 862-76. PMID 24286250 DOI: 10.1111/Febs.12654  0.629
2014 Watts J, Giles K, Grillo S, Lemus A, DeArmond S, Prusiner S. Erratum: Bioluminescence imaging of Aβ deposition in bigenic mouse models of Alzheimer's disease (Proceedings of the National Academy of Sciences of the United States of America (2011) 108 (2528-2533) DOI: 10.1073/pnas. 1019034108) Proceedings of the National Academy of Sciences of the United States of America. 111: 3895. DOI: 10.1073/Pnas.1401579111  0.498
2013 Mercer RC, Ma L, Watts JC, Strome R, Wohlgemuth S, Yang J, Cashman NR, Coulthart MB, Schmitt-Ulms G, Jhamandas JH, Westaway D. The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. The Journal of Biological Chemistry. 288: 37241-55. PMID 24225951 DOI: 10.1074/Jbc.M113.488650  0.662
2013 Watts JC, Giles K, Oehler A, Middleton L, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB. Transmission of multiple system atrophy prions to transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 110: 19555-60. PMID 24218576 DOI: 10.1073/Pnas.1318268110  0.593
2013 Berry DB, Lu D, Geva M, Watts JC, Bhardwaj S, Oehler A, Renslo AR, DeArmond SJ, Prusiner SB, Giles K. Drug resistance confounding prion therapeutics. Proceedings of the National Academy of Sciences of the United States of America. 110: E4160-9. PMID 24128760 DOI: 10.1073/Pnas.1317164110  0.616
2013 Stoehr J, Watts J, Oehler A, DeArmond S, Giles K, Prusiner SB. P1-043: Synthetic beta-amyloid prions Alzheimer's & Dementia. 9: P168-P168. DOI: 10.1016/J.Jalz.2013.05.263  0.438
2012 Stöhr J, Watts JC, Mensinger ZL, Oehler A, Grillo SK, DeArmond SJ, Prusiner SB, Giles K. Purified and synthetic Alzheimer's amyloid beta (Aβ) prions. Proceedings of the National Academy of Sciences of the United States of America. 109: 11025-30. PMID 22711819 DOI: 10.1073/Pnas.1206555109  0.586
2012 Watts JC, Giles K, Stöhr J, Oehler A, Bhardwaj S, Grillo SK, Patel S, DeArmond SJ, Prusiner SB. Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein. Proceedings of the National Academy of Sciences of the United States of America. 109: 3498-503. PMID 22331873 DOI: 10.1073/Pnas.1121556109  0.615
2012 Stoehr J, Watts J, Mensinger Z, Oehler A, Grillo S, DeArmond S, Prusiner S, Giles K. O3-04-01: Brain-derived and synthetic Aβ aggregates are prions Alzheimer's & Dementia. 8: P434-P434. DOI: 10.1016/J.Jalz.2012.05.1158  0.509
2011 Watts JC, Stöhr J, Bhardwaj S, Wille H, Oehler A, Dearmond SJ, Giles K, Prusiner SB. Protease-resistant prions selectively decrease Shadoo protein. Plos Pathogens. 7: e1002382. PMID 22163178 DOI: 10.1371/Journal.Ppat.1002382  0.641
2011 Stöhr J, Watts JC, Legname G, Oehler A, Lemus A, Nguyen HO, Sussman J, Wille H, DeArmond SJ, Prusiner SB, Giles K. Spontaneous generation of anchorless prions in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 21223-8. PMID 22160704 DOI: 10.1073/Pnas.1117827108  0.642
2011 Ghaemmaghami S, Watts JC, Nguyen HO, Hayashi S, DeArmond SJ, Prusiner SB. Conformational transformation and selection of synthetic prion strains. Journal of Molecular Biology. 413: 527-42. PMID 21839745 DOI: 10.1016/J.Jmb.2011.07.021  0.695
2011 Watts JC, Giles K, Grillo SK, Lemus A, DeArmond SJ, Prusiner SB. Bioluminescence imaging of Abeta deposition in bigenic mouse models of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 108: 2528-33. PMID 21262831 DOI: 10.1073/Pnas.1019034108  0.582
2011 Ehsani S, Huo H, Salehzadeh A, Pocanschi CL, Watts JC, Wille H, Westaway D, Rogaeva E, St George-Hyslop PH, Schmitt-Ulms G. Family reunion--the ZIP/prion gene family. Progress in Neurobiology. 93: 405-20. PMID 21163327 DOI: 10.1016/J.Pneurobio.2010.12.001  0.688
2010 Daude N, Ng V, Watts JC, Genovesi S, Glaves JP, Wohlgemuth S, Schmitt-Ulms G, Young H, McLaurin J, Fraser PE, Westaway D. Wild-type Shadoo proteins convert to amyloid-like forms under native conditions. Journal of Neurochemistry. 113: 92-104. PMID 20067571 DOI: 10.1111/J.1471-4159.2010.06575.X  0.678
2010 Wille H, Ehsani S, Watts JC, Westaway D, Schmitt-Ulms G. Descent of the Prion Protein Gene Family from the Extracellular Domain of an Ancestral Zip Metal Ion Transporter Biophysical Journal. 98: 708a. DOI: 10.1016/J.Bpj.2009.12.3883  0.675
2009 Watts JC, Huo H, Bai Y, Ehsani S, Jeon AH, Won AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson GA, Williams D, Westaway D, Schmitt-Ulms G. Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones. Plos Pathogens. 5: e1000608. PMID 19798432 DOI: 10.1371/Journal.Ppat.1000608  0.689
2009 Schmitt-Ulms G, Ehsani S, Watts JC, Westaway D, Wille H. Evolutionary descent of prion genes from the ZIP family of metal ion transporters. Plos One. 4: e7208. PMID 19784368 DOI: 10.1371/Journal.Pone.0007208  0.665
2009 Schmitt-Ulms G, Ehsani S, Watts JC, Westaway D, Wille H. Evolutionary descent of prion genes from a ZIP metal ion transport ancestor Nature Precedings. 4: 1-1. DOI: 10.1038/Npre.2009.2867.1  0.668
2008 Bai Y, Markham K, Chen F, Weerasekera R, Watts J, Horne P, Wakutani Y, Bagshaw R, Mathews PM, Fraser PE, Westaway D, St George-Hyslop P, Schmitt-Ulms G. The in vivo brain interactome of the amyloid precursor protein. Molecular & Cellular Proteomics : McP. 7: 15-34. PMID 17934213 DOI: 10.1074/Mcp.M700077-Mcp200  0.677
2007 Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, et al. The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. The Embo Journal. 26: 4038-50. PMID 17703189 DOI: 10.1038/Sj.Emboj.7601830  0.692
2007 Watts JC, Westaway D. The prion protein family: diversity, rivalry, and dysfunction. Biochimica Et Biophysica Acta. 1772: 654-72. PMID 17562432 DOI: 10.1016/J.Bbadis.2007.05.001  0.475
2006 Watts JC, Balachandran A, Westaway D. The expanding universe of prion diseases Plos Pathogens. 2. PMID 16609731 DOI: 10.1371/Journal.Ppat.0020026  0.436
2006 Ng VW, Watts JC, Schmitt-Ulms G, Westaway D. P4-150: Preliminary characterization and structural analysis of the prion protein Homolog, Shadoo Alzheimer's & Dementia. 2: S560-S560. DOI: 10.1016/J.Jalz.2006.05.1889  0.632
2006 Watts JC, Drisaldi B, Strome B, Yang J, Fraser PE, Mount HT, Schmitt-Ulms G, Westaway D. P4-149: Shadoo is a novel mammalian protein exhibiting partial redundancy with PRPC Alzheimer's & Dementia. 2: S559-S559. DOI: 10.1016/J.Jalz.2006.05.1888  0.626
2004 Drisaldi B, Coomaraswamy J, Mastrangelo P, Strome B, Yang J, Watts JC, Chishti MA, Marvi M, Windl O, Ahrens R, Major F, Sy MS, Kretzschmar H, Fraser PE, Mount HT, et al. Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region. The Journal of Biological Chemistry. 279: 55443-54. PMID 15459186 DOI: 10.1074/Jbc.M404794200  0.454
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