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Christoph Fahrni, PhD - Publications

Affiliations: 
Chemistry Georgia Institute of Technology, Atlanta, GA 
Area:
Metals in Biology
Website:
http://ww2.chemistry.gatech.edu/dept/faculty/Fahrni/
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63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Yu J, Bacsa J, Fahrni CJ. Conformationally Preorganized High-Affinity Ligands for Copper Biology with Hinged and Rigid Thiophene Backbones. Inorganic Chemistry. 62: 1287-1296. PMID 36661323 DOI: 10.1021/acs.inorgchem.2c03524  0.406
2020 Abeyrathna N, Abeyrathna S, Morgan MT, Fahrni CJ, Meloni G. Transmembrane Cu(i) P-type ATPase pumps are electrogenic uniporters. Dalton Transactions (Cambridge, England : 2003). PMID 32469032 DOI: 10.1039/d0dt01380c  0.327
2019 Morgan MT, Bourassa D, Harankhedkar S, McCallum AM, Zlatic SA, Calvo JS, Meloni G, Faundez V, Fahrni CJ. Ratiometric two-photon microscopy reveals attomolar copper buffering in normal and Menkes mutant cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 31160463 DOI: 10.1073/Pnas.1900172116  0.371
2019 Saeedifard F, Morgan MT, Bacsa J, Fahrni CJ. Preorganized PSP Ligands Yield Monomeric Cu(I) Complexes with Subzeptomolar Cu(I) Dissociation Constants. Inorganic Chemistry. PMID 31124662 DOI: 10.1021/acs.inorgchem.9b00965  0.363
2018 Morgan MT, Yang B, Harankhedkar S, Nabatilan A, Bourassa D, McCallum AM, Sun F, Wu R, Forest CR, Fahrni CJ. Stabilization of aliphatic phosphines by auxiliary phosphine sulfides offers zeptomolar affinity and unprecedented selectivity for probing biological Cu(I). Angewandte Chemie (International Ed. in English). PMID 29885022 DOI: 10.1002/Anie.201804072  0.377
2018 Bourassa D, Elitt CM, McCallum AM, Sumalekshmy S, McRae RL, Morgan MT, Siegel N, Perry JW, Rosenberg PA, Fahrni CJ. Chromis-1, a Ratiometric Fluorescent Probe Optimized for Two-Photon Microscopy Reveals Dynamic Changes in Labile Zn(II) in Differentiating Oligodendrocytes. Acs Sensors. PMID 29431427 DOI: 10.1021/Acssensors.7B00887  0.788
2017 Morgan MT, Nguyen LAH, Hancock HL, Fahrni CJ. Glutathione limits aquacopper(I) to sub-femtomolar concentrations through cooperative assembly of a tetranuclear cluster. The Journal of Biological Chemistry. PMID 29101230 DOI: 10.1074/jbc.M117.817452  0.301
2016 Morgan MT, McCallum AM, Fahrni CJ. Rational design of a water-soluble, lipid-compatible fluorescent probe for Cu(I) with sub-part-per-trillion sensitivity Chemical Science. 7: 1468-1473. DOI: 10.1039/c5sc03643g  0.304
2014 Morgan MT, Sumalekshmy S, Sarwar M, Beck H, Crooke S, Fahrni CJ. Probing ternary complex equilibria of crown ether ligands by time-resolved fluorescence spectroscopy. The Journal of Physical Chemistry. B. 118: 14196-202. PMID 25313708 DOI: 10.1021/jp5077406  0.394
2014 Vogt S, Gleber SC, Jin Q, Chen S, Finney L, Jacobsen C, Ralle M, Fahrni C, Mustafi D. Biological X-ray fluorescence microscopy: Advances and unique opportunities Microscopy and Microanalysis. 20: 1306-1307. DOI: 10.1017/S1431927614008265  0.625
2014 Vogt S, Gleber SC, Jin Q, Chen S, Finney L, Jacobsen C, Ralle M, Fahrni C, Mustafi D. Biological X-ray fluorescence microscopy: Advances and unique opportunities Microscopy and Microanalysis. 20: 1306-1307. DOI: 10.1017/S1431927614008265  0.625
2013 Bagchi P, Morgan MT, Bacsa J, Fahrni CJ. Robust affinity standards for Cu(I) biochemistry Journal of the American Chemical Society. 135: 18549-18559. PMID 24298878 DOI: 10.1021/ja408827d  0.331
2013 Fahrni CJ. Synthetic fluorescent probes for monovalent copper Current Opinion in Chemical Biology. 17: 656-662. PMID 23769869 DOI: 10.1016/j.cbpa.2013.05.019  0.408
2013 Fahrni CJ. Synthetic fluorescent probes for monovalent copper Current Opinion in Chemical Biology. 17: 656-662. PMID 23769869 DOI: 10.1016/j.cbpa.2013.05.019  0.364
2013 McRae R, Lai B, Fahrni CJ. Subcellular redistribution and mitotic inheritance of transition metals in proliferating mouse fibroblast cells Metallomics. 5: 52-61. PMID 23212029 DOI: 10.1039/C2Mt20176C  0.775
2013 Morgan MT, Bagchi P, Fahrni CJ. High-contrast fluorescence sensing of aqueous Cu(i) with triarylpyrazoline probes: Dissecting the roles of ligand donor strength and excited state proton transfer Dalton Transactions. 42: 3240-3248. PMID 23169532 DOI: 10.1039/c2dt31985c  0.452
2013 Morgan MT, Bagchi P, Fahrni CJ. High-contrast fluorescence sensing of aqueous Cu(i) with triarylpyrazoline probes: Dissecting the roles of ligand donor strength and excited state proton transfer Dalton Transactions. 42: 3240-3248. PMID 23169532 DOI: 10.1039/c2dt31985c  0.415
2011 Sumalekshmy S, Fahrni CJ. Metal Ion-Responsive Fluorescent Probes for Two-Photon Excitation Microscopy. Chemistry of Materials : a Publication of the American Chemical Society. 23: 483-500. PMID 28503029 DOI: 10.1021/cm1021905  0.321
2011 Chaudhry AF, Mandal S, Hardcastle KI, Fahrni CJ. High-contrast Cu(I)-selective fluorescent probes based on synergistic electronic and conformational switching. Chemical Science (Royal Society of Chemistry : 2010). 2: 1016-1024. PMID 21949587 DOI: 10.1039/C1SC00024A  0.433
2011 Chaudhry AF, Mandal S, Hardcastle KI, Fahrni CJ. High-contrast Cu(I)-selective fluorescent probes based on synergistic electronic and conformational switching. Chemical Science (Royal Society of Chemistry : 2010). 2: 1016-1024. PMID 21949587 DOI: 10.1039/C1SC00024A  0.433
2011 Morgan MT, Bagchi P, Fahrni CJ. Designed to dissolve: Suppression of colloidal aggregation of Cu(I)-selective fluorescent probes in aqueous buffer and in-gel detection of a metallochaperone Journal of the American Chemical Society. 133: 15906-15909. PMID 21916472 DOI: 10.1021/ja207004v  0.318
2011 Morgan MT, Bagchi P, Fahrni CJ. Designed to dissolve: Suppression of colloidal aggregation of Cu(I)-selective fluorescent probes in aqueous buffer and in-gel detection of a metallochaperone Journal of the American Chemical Society. 133: 15906-15909. PMID 21916472 DOI: 10.1021/ja207004v  0.402
2011 Sumalekshmy S, Fahrni CJ. Metal-ion-responsive fluorescent probes for two-photon excitation microscopy Chemistry of Materials. 23: 483-500. DOI: 10.1021/cm1021905  0.31
2011 Sumalekshmy S, Fahrni CJ. Metal-ion-responsive fluorescent probes for two-photon excitation microscopy Chemistry of Materials. 23: 483-500. DOI: 10.1021/cm1021905  0.31
2010 Verma M, Chaudhry AF, Morgan MT, Fahrni CJ. Electronically tuned 1,3,5-triarylpyrazolines as Cu(I)-selective fluorescent probes Organic and Biomolecular Chemistry. 8: 363-370. PMID 20066271 DOI: 10.1039/b918311f  0.45
2010 Verma M, Chaudhry AF, Morgan MT, Fahrni CJ. Electronically tuned 1,3,5-triarylpyrazolines as Cu(I)-selective fluorescent probes Organic and Biomolecular Chemistry. 8: 363-370. PMID 20066271 DOI: 10.1039/b918311f  0.356
2010 Chaudhry AF, Verma M, Thomas Morgan M, Henary MM, Siegel N, Hales JM, Perry JW, Fahrni CJ. Kinetically controlled photoinduced electron transfer switching in Cu(I)-responsive fluorescent probes Journal of the American Chemical Society. 132: 737-747. PMID 20020716 DOI: 10.1021/Ja908326Z  0.439
2010 McRae R, Lai B, Fahrni CJ. Copper redistribution in Atox1-deficient mouse fibroblast cells Journal of Biological Inorganic Chemistry. 15: 99-105. PMID 19865834 DOI: 10.1007/S00775-009-0598-1  0.761
2009 Fahrni CJ. Fluorescent Probes and Labels for Cellular Imaging. Chimia. 63: 714-720. PMID 29104302 DOI: 10.2533/chimia.2009.714  0.343
2009 McRae R, Bagchi P, Sumalekshmy S, Fahrni CJ. In situ imaging of metals in cells and tissues Chemical Reviews. 109: 4780-4827. PMID 19772288 DOI: 10.1021/Cr900223A  0.743
2008 Cody J, Mandal S, Yang L, Fahrni CJ. Differential tuning of the electron transfer parameters in 1,3,5-triarylpyrazolines: A rational design approach for optimizing the contrast ratio of fluorescent probes Journal of the American Chemical Society. 130: 13023-13032. PMID 18767839 DOI: 10.1021/Ja803074Y  0.774
2008 McRae RL, Phillips RL, Kim IB, Bunz UH, Fahrni CJ. Molecular recognition based on low-affinity polyvalent interactions: selective binding of a carboxylated polymer to fibronectin fibrils of live fibroblast cells. Journal of the American Chemical Society. 130: 7851-3. PMID 18507462 DOI: 10.1021/Ja8007402  0.741
2008 McRae RL, Phillips RL, Kim IB, Bunz UH, Fahrni CJ. Molecular recognition based on low-affinity polyvalent interactions: selective binding of a carboxylated polymer to fibronectin fibrils of live fibroblast cells. Journal of the American Chemical Society. 130: 7851-3. PMID 18507462 DOI: 10.1021/Ja8007402  0.741
2007 Sumalekshmy S, Henary MM, Siegel N, Lawson PV, Wu Y, Schmidt K, Brédas JL, Perry JW, Fahrni CJ. Design of emission ratiometric metal-ion sensors with enhanced two-photon cross section and brightness Journal of the American Chemical Society. 129: 11888-11889. PMID 17845038 DOI: 10.1021/Ja073240O  0.661
2007 Sumalekshmy S, Henary MM, Siegel N, Lawson PV, Wu Y, Schmidt K, Brédas JL, Perry JW, Fahrni CJ. Design of emission ratiometric metal-ion sensors with enhanced two-photon cross section and brightness Journal of the American Chemical Society. 129: 11888-11889. PMID 17845038 DOI: 10.1021/Ja073240O  0.661
2007 Henary MM, Wu Y, Cody J, Sumalekshmy S, Li J, Mandal S, Fahrni CJ. Excited-state intramolecular proton transfer in 2-(2′- arylsulfonamidophenyl)benzimidazole derivatives: The effect of donor and acceptor substituents Journal of Organic Chemistry. 72: 4784-4797. PMID 17523666 DOI: 10.1021/Jo070433L  0.795
2007 Henary MM, Wu Y, Cody J, Sumalekshmy S, Li J, Mandal S, Fahrni CJ. Excited-state intramolecular proton transfer in 2-(2′- arylsulfonamidophenyl)benzimidazole derivatives: The effect of donor and acceptor substituents Journal of Organic Chemistry. 72: 4784-4797. PMID 17523666 DOI: 10.1021/Jo070433L  0.795
2007 Wu Y, Lawson PV, Henary MM, Schmidt K, Brédas JL, Fahrni CJ. Excited state intramolecular proton transfer in 2-(2′- arylsulfonamidophenyl)benzimidazole derivatives: insights into the origin of donor substituent-induced emission energy shifts Journal of Physical Chemistry A. 111: 4584-4595. PMID 17489564 DOI: 10.1021/Jp068832S  0.611
2007 Wu Y, Lawson PV, Henary MM, Schmidt K, Brédas JL, Fahrni CJ. Excited state intramolecular proton transfer in 2-(2′- arylsulfonamidophenyl)benzimidazole derivatives: insights into the origin of donor substituent-induced emission energy shifts Journal of Physical Chemistry A. 111: 4584-4595. PMID 17489564 DOI: 10.1021/Jp068832S  0.611
2006 McRae R, Lai B, Vogt S, Fahrni CJ. Correlative microXRF and optical immunofluorescence microscopy of adherent cells labeled with ultrasmall gold particles Journal of Structural Biology. 155: 22-29. PMID 16473527 DOI: 10.1016/J.Jsb.2005.09.013  0.737
2005 Yang L, McRae R, Henary MM, Patel R, Lai B, Vogt S, Fahrni CJ. Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron x-ray fluorescence microscopy Proceedings of the National Academy of Sciences of the United States of America. 102: 11179-11184. PMID 16061820 DOI: 10.1073/Pnas.0406547102  0.804
2005 Yang L, McRae R, Henary MM, Patel R, Lai B, Vogt S, Fahrni CJ. Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron x-ray fluorescence microscopy Proceedings of the National Academy of Sciences of the United States of America. 102: 11179-11184. PMID 16061820 DOI: 10.1073/Pnas.0406547102  0.804
2004 Zhou Z, Fahrni CJ. A fluorogenic probe for the copper(I)-catalyzed azide-alkyne ligation reaction: Modulation of the fluorescence emission via 3(n, π*)-1(π,π*) inversion Journal of the American Chemical Society. 126: 8862-8863. PMID 15264794 DOI: 10.1021/Ja049684R  0.336
2004 Zhou Z, Fahrni CJ. A fluorogenic probe for the copper(I)-catalyzed azide-alkyne ligation reaction: Modulation of the fluorescence emission via 3(n, π*)-1(π,π*) inversion Journal of the American Chemical Society. 126: 8862-8863. PMID 15264794 DOI: 10.1021/ja049684r  0.327
2004 Henary MM, Wu Y, Fahrni CJ. Zinc(II)-selective ratiometric fluorescent sensors based on inhibition of excited-state intramolecular proton transfer. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 3015-25. PMID 15214085 DOI: 10.1002/Chem.200305299  0.662
2004 Samia ACS, Cody J, Fahrni CJ, Burda C. The Effect of Ligand Constraints on the Metal-to-Ligand Charge-Tranfer Relaxation Dynamics of Copper(I)-Phenanthroline Complexes: A Comparative Study by Femtosecond Time-Resolved Spectroscopy Journal of Physical Chemistry B. 108: 563-569. DOI: 10.1021/Jp036857A  0.79
2004 Cody J, Fahrni CJ. Fluorescence sensing based on cation-induced conformational switching: Copper-selective modulation of the photoinduced intramolecular charge transfer of a donor-acceptor biphenyl fluorophore Tetrahedron. 60: 11099-11107. DOI: 10.1016/J.Tet.2004.08.056  0.829
2004 Cody J, Fahrni CJ. Fluorescence sensing based on cation-induced conformational switching: Copper-selective modulation of the photoinduced intramolecular charge transfer of a donor-acceptor biphenyl fluorophore Tetrahedron. 60: 11099-11107. DOI: 10.1016/j.tet.2004.08.056  0.326
2004 Henary MM, Wu Y, Fahrni CJ. Zinc(II)-selective ratiometric fluorescent sensors based on inhibition of excited-state intramolecular proton transfer Chemistry - a European Journal. 10: 3015-3025. DOI: 10.1002/chem.200305299  0.628
2003 Cody J, Dennisson J, Gilmore J, VanDerveer DG, Henary MM, Gabrielli A, Sherrill CD, Zhang Y, Pan CP, Burda C, Fahrni CJ. X-ray structures, photophysical characterization, and computational analysis of geometrically constrained copper(I)--phenanthroline complexes. Inorganic Chemistry. 42: 4918-29. PMID 12895116 DOI: 10.1021/Ic034529J  0.81
2003 Fahrni CJ, Yang L, VanDerveer DG. Tuning the photoinduced electron-transfer thermodynamics in 1,3,5-triaryl-2-pyrazoline fluorophores: X-ray structures, photophysical characterization, computational analysis, and in vivo evaluation Journal of the American Chemical Society. 125: 3799-3812. PMID 12656613 DOI: 10.1021/Ja028266O  0.751
2002 Fahrni CJ, Henary MM, VanDerveer DG. Excited-state intramolecular proton transfer in 2-(2′-tosylaminophenyl)benzimidazole Journal of Physical Chemistry A. 106: 7655-7663. DOI: 10.1021/Jp0204915  0.319
2002 Fahrni CJ, Henary MM, VanDerveer DG. Excited-state intramolecular proton transfer in 2-(2′-tosylaminophenyl)benzimidazole Journal of Physical Chemistry A. 106: 7655-7663. DOI: 10.1021/Jp0204915  0.319
2002 Henary MM, Fahrni CJ. Excited state intramolecular proton transfer and metal ion complexation of 2-(2′-hydroxyphenyl)benzazoles in aqueous solution Journal of Physical Chemistry A. 106: 5210-5220. DOI: 10.1021/Jp014634J  0.365
2002 Henary MM, Fahrni CJ. Excited state intramolecular proton transfer and metal ion complexation of 2-(2′-hydroxyphenyl)benzazoles in aqueous solution Journal of Physical Chemistry A. 106: 5210-5220. DOI: 10.1021/Jp014634J  0.365
1999 Nasir MS, Fahrni CJ, Suhy DA, Kolodsick KJ, Singer CP, O'Halloran TV. The chemical cell biology of zinc: structure and intracellular fluorescence of a zinc-quinolinesulfonamide complex. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 4: 775-83. PMID 10631609 DOI: 10.1007/S007750050350  0.803
1999 Nasir MS, Fahrni CJ, Suhy DA, Kolodsick KJ, Singer CP, O'Halloran TV. The chemical cell biology of zinc: structure and intracellular fluorescence of a zinc-quinolinesulfonamide complex. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 4: 775-83. PMID 10631609 DOI: 10.1007/S007750050350  0.803
1999 Fahrni CJ, O'Halloran TV. Aqueous coordination chemistry of quinoline-based fluorescence probes for the biological chemistry of zinc Journal of the American Chemical Society. 121: 11448-11458. DOI: 10.1021/Ja992709F  0.629
1999 Fahrni CJ, O'Halloran TV. Aqueous coordination chemistry of quinoline-based fluorescence probes for the biological chemistry of zinc Journal of the American Chemical Society. 121: 11448-11458. DOI: 10.1021/Ja992709F  0.629
1998 Fahrni CJ, Pfaltz A, Neuburger M, Zehnder M. Structure and Properties of Transition-Metal Complexes with Chiral C2-Symmetric Binucleating Ligands Helvetica Chimica Acta. 81: 507-524. DOI: 10.1002/Hlca.19980810305  0.518
1998 Fahrni CJ, Pfaltz A. Synthesis of Chiral C2-Symmetric Binucleating Ligands Helvetica Chimica Acta. 81: 491-506. DOI: 10.1002/Hlca.19980810304  0.463
1997 Pufahl RA, Singer CP, Peariso KL, Lin SJ, Schmidt PJ, Fahrni CJ, Culotta VC, Penner-Hahn JE, O'Halloran TV. Metal ion chaperone function of the soluble Cu(I) receptor Atx1. Science (New York, N.Y.). 278: 853-6. PMID 9346482 DOI: 10.1126/Science.278.5339.853  0.741
1992 Leutenegger U, Umbricht G, Fahrni C, von Matt P, Pfaltz A. 5-aza-semicorrins: A new class of bidentate nitrogen ligands for enantioselective catalysis Tetrahedron. 48: 2143-2156. DOI: 10.1016/S0040-4020(01)88880-3  0.55
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