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Keyong O-K Chang - Publications

Affiliations: 
Veterinary Medicine Kansas State University, Manhattan, KS, United States 
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Rathnayake AD, Zheng J, Kim Y, Perera KD, Mackin S, Meyerholz DK, Kashipathy MM, Battaile KP, Lovell S, Perlman S, Groutas WC, Chang KO. 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice. Science Translational Medicine. PMID 32747425 DOI: 10.1126/Scitranslmed.Abc5332  0.676
2019 Chang KO, Kim Y, Lovell S, Rathnayake AD, Groutas WC. Antiviral Drug Discovery: Norovirus Proteases and Development of Inhibitors. Viruses. 11. PMID 30823509 DOI: 10.3390/V11020197  0.708
2018 Perera KD, Galasiti Kankanamalage AC, Rathnayake AD, Honeyfield A, Groutas W, Chang KO, Kim Y. Protease inhibitors broadly effective against feline, ferret and mink coronaviruses. Antiviral Research. PMID 30342822 DOI: 10.1016/J.Antiviral.2018.10.015  0.674
2018 Dang W, Xu L, Ma B, Chen S, Yin Y, Chang KO, Peppelenbosch MP, Pan Q. Nitazoxanide Inhibits Human Norovirus Replication and Synergizes with Ribavirin by Activation of Cellular Antiviral Response. Antimicrobial Agents and Chemotherapy. PMID 30104275 DOI: 10.1128/AAC.00707-18  0.352
2018 Galasiti Kankanamalage AC, Kim Y, Damalanka VC, Rathnayake AD, Fehr AR, Mehzabeen N, Battaile KP, Lovell S, Lushington GH, Perlman S, Chang KO, Groutas WC. Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element. European Journal of Medicinal Chemistry. 150: 334-346. PMID 29544147 DOI: 10.1016/J.Ejmech.2018.03.004  0.677
2018 Kim Y, Chang KO. Protein Disulfide Isomerases as potential therapeutic targets for Influenza A and B Viruses. Virus Research. PMID 29382552 DOI: 10.1016/J.Virusres.2018.01.010  0.306
2018 Damalanka VC, Kim Y, Galasiti Kankanamalage AC, Rathnayake AD, Mehzabeen N, Battaile KP, Lovell S, Nguyen HN, Lushington GH, Chang KO, Groutas WC. Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease. European Journal of Medicinal Chemistry. 143: 881-890. PMID 29227928 DOI: 10.1016/J.Ejmech.2017.12.014  0.675
2017 Pedersen NC, Kim Y, Liu H, Galasiti Kankanamalage AC, Eckstrand C, Groutas WC, Bannasch M, Meadows JM, Chang KO. Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis. Journal of Feline Medicine and Surgery. 1098612X17729626. PMID 28901812 DOI: 10.1177/1098612X17729626  0.512
2017 Dang W, Yin Y, Wang Y, Wang W, Su J, Sprengers D, van der Laan LJW, Felczak K, Pankiewicz KW, Chang KO, Koopmans MPG, Metselaar HJ, Peppelenbosch MP, Pan Q. Inhibition of calcineurin or IMPDH exerts moderate to potent antiviral activity against norovirus replication. Antimicrobial Agents and Chemotherapy. PMID 28807916 DOI: 10.1128/AAC.01095-17  0.414
2017 Galasiti Kankanamalage AC, Kim Y, Rathnayake AD, Alliston KR, Butler MM, Cardinale SC, Bowlin TL, Groutas WC, Chang KO. Design, Synthesis, and Evaluation of Novel Prodrugs of Transition State Inhibitors of Norovirus 3CL Protease. Journal of Medicinal Chemistry. PMID 28671827 DOI: 10.1021/Acs.Jmedchem.7B00497  0.656
2016 Damalanka VC, Kim Y, Galasiti Kankanamalage AC, Lushington GH, Mehzabeen N, Battaile KP, Lovell S, Chang KO, Groutas WC. Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease. European Journal of Medicinal Chemistry. 127: 41-61. PMID 28038326 DOI: 10.1016/J.Ejmech.2016.12.033  0.721
2016 Galasiti Kankanamalage AC, Kim Y, Rathnayake AD, Damalanka VC, Weerawarna PM, Doyle ST, Alsoudi AF, Dissanayake DM, Lushington GH, Mehzabeen N, Battaile KP, Lovell S, Chang KO, Groutas WC. Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors. European Journal of Medicinal Chemistry. 126: 502-516. PMID 27914364 DOI: 10.1016/J.Ejmech.2016.11.027  0.675
2016 Weerawarna PM, Kim Y, Galasiti Kankanamalage AC, Damalanka VC, Lushington GH, Alliston KR, Mehzabeen N, Battaile KP, Lovell S, Chang KO, Groutas WC. Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies. European Journal of Medicinal Chemistry. 119: 300-318. PMID 27235842 DOI: 10.1016/J.Ejmech.2016.04.013  0.698
2016 Kim Y, Liu H, Kankanamalage AC, Weerasekara S, Hua DH, Groutas WC, Chang KO, Pedersen NC. Correction: Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor. Plos Pathogens. 12: e1005650. PMID 27166862 DOI: 10.1371/Journal.Ppat.1005650  0.581
2016 Kim Y, Liu H, Galasiti Kankanamalage AC, Weerasekara S, Hua DH, Groutas WC, Chang KO, Pedersen NC. Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor. Plos Pathogens. 12: e1005531. PMID 27027316 DOI: 10.1371/Journal.Ppat.1005531  0.638
2016 Galasiti Kankanamalage AC, Weerawarna PM, Kim Y, Chang KO, Groutas WC. Anti-Norovirus Therapeutics: A Patent Review (2010-2015). Expert Opinion On Therapeutic Patents. PMID 26881878 DOI: 10.1517/13543776.2016.1153065  0.591
2016 Damalanka VC, Kim Y, Alliston KR, Weerawarna PM, Galasiti Kankanamalage AC, Lushington GH, Mehzabeen N, Battaile KP, Lovell SW, Chang KO, Groutas WC. Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease. Journal of Medicinal Chemistry. PMID 26823007 DOI: 10.1021/Acs.Jmedchem.5B01464  0.697
2015 Kim Y, Galasiti Kankanamalage AC, Damalanka VC, Weerawarna PM, Groutas WC, Chang KO. Potent Inhibition of Enterovirus D68 and Human Rhinoviruses by Dipeptidyl Aldehydes and α-Ketoamides. Antiviral Research. PMID 26658373 DOI: 10.1016/J.Antiviral.2015.11.010  0.598
2015 Kim Y, Galasiti Kankanamalage AC, Chang KO, Groutas WC. Recent Advances in the Discovery of Norovirus Therapeutics. Journal of Medicinal Chemistry. PMID 26258852 DOI: 10.1021/Acs.Jmedchem.5B00762  0.595
2015 Galasiti Kankanamalage AC, Kim Y, Weerawarna PM, Uy RA, Damalanka VC, Mandadapu SR, Alliston KR, Mehzabeen N, Battaile KP, Lovell S, Chang KO, Groutas WC. Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies. Journal of Medicinal Chemistry. 58: 3144-55. PMID 25761614 DOI: 10.1021/Jm5019934  0.689
2015 Kim Y, Shivanna V, Narayanan S, Prior AM, Weerasekara S, Hua DH, Kankanamalage AC, Groutas WC, Chang KO. Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses. Journal of Virology. 89: 4942-50. PMID 25694593 DOI: 10.1128/Jvi.03688-14  0.704
2013 Prior AM, Kim Y, Weerasekara S, Moroze M, Alliston KR, Uy RA, Groutas WC, Chang KO, Hua DH. Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 6317-20. PMID 24125888 DOI: 10.1016/J.Bmcl.2013.09.070  0.656
2013 Takahashi D, Kim Y, Lovell S, Prakash O, Groutas WC, Chang KO. Structural and inhibitor studies of norovirus 3C-like proteases. Virus Research. 178: 437-44. PMID 24055466 DOI: 10.1016/J.Virusres.2013.09.008  0.654
2013 Mandadapu SR, Gunnam MR, Galasiti Kankanamalage AC, Uy RA, Alliston KR, Lushington GH, Kim Y, Chang KO, Groutas WC. Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics. Bioorganic & Medicinal Chemistry Letters. 23: 5941-4. PMID 24054123 DOI: 10.1016/J.Bmcl.2013.08.073  0.636
2013 Mandadapu SR, Weerawarna PM, Prior AM, Uy RA, Aravapalli S, Alliston KR, Lushington GH, Kim Y, Hua DH, Chang KO, Groutas WC. Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus. Bioorganic & Medicinal Chemistry Letters. 23: 3709-12. PMID 23727045 DOI: 10.1016/J.Bmcl.2013.05.021  0.61
2013 Kim Y, Mandadapu SR, Groutas WC, Chang KO. Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease. Antiviral Research. 97: 161-8. PMID 23219425 DOI: 10.1016/J.Antiviral.2012.11.005  0.702
2013 Mandadapu SR, Gunnam MR, Tiew KC, Uy RA, Prior AM, Alliston KR, Hua DH, Kim Y, Chang KO, Groutas WC. Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 62-5. PMID 23218713 DOI: 10.1016/J.Bmcl.2012.11.026  0.665
2012 Kim Y, Lovell S, Tiew KC, Mandadapu SR, Alliston KR, Battaile KP, Groutas WC, Chang KO. Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses. Journal of Virology. 86: 11754-62. PMID 22915796 DOI: 10.1128/Jvi.01348-12  0.683
2012 Perry JW, Ahmed M, Chang KO, Donato NJ, Showalter HD, Wobus CE. Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response. Plos Pathogens. 8: e1002783. PMID 22792064 DOI: 10.1371/Journal.Ppat.1002783  0.395
2012 Mandadapu SR, Weerawarna PM, Gunnam MR, Alliston KR, Lushington GH, Kim Y, Chang KO, Groutas WC. Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles. Bioorganic & Medicinal Chemistry Letters. 22: 4820-6. PMID 22698498 DOI: 10.1016/J.Bmcl.2012.05.055  0.628
2012 Pokhrel L, Kim Y, Nguyen TD, Prior AM, Lu J, Chang KO, Hua DH. Synthesis and anti-norovirus activity of pyranobenzopyrone compounds. Bioorganic & Medicinal Chemistry Letters. 22: 3480-4. PMID 22513282 DOI: 10.1016/J.Bmcl.2012.03.084  0.336
2012 Kim Y, George D, Prior AM, Prasain K, Hao S, Le DD, Hua DH, Chang KO. Novel triacsin C analogs as potential antivirals against rotavirus infections. European Journal of Medicinal Chemistry. 50: 311-8. PMID 22365411 DOI: 10.1016/J.Ejmech.2012.02.010  0.344
2012 Dou D, Tiew KC, Mandadapu SR, Gunnam MR, Alliston KR, Kim Y, Chang KO, Groutas WC. Potent norovirus inhibitors based on the acyclic sulfamide scaffold. Bioorganic & Medicinal Chemistry. 20: 2111-8. PMID 22356738 DOI: 10.1016/J.Bmc.2012.01.030  0.673
2012 Chang KO, Takahashi D, Prakash O, Kim Y. Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay. Virology. 423: 125-33. PMID 22200497 DOI: 10.1016/J.Virol.2011.12.002  0.357
2012 Dou D, He G, Mandadapu SR, Aravapalli S, Kim Y, Chang KO, Groutas WC. Inhibition of noroviruses by piperazine derivatives. Bioorganic & Medicinal Chemistry Letters. 22: 377-9. PMID 22119464 DOI: 10.1016/J.Bmcl.2011.10.122  0.65
2012 Thapa M, Kim Y, Desper J, Chang KO, Hua DH. Synthesis and antiviral activity of substituted quercetins. Bioorganic & Medicinal Chemistry Letters. 22: 353-6. PMID 22115591 DOI: 10.1016/J.Bmcl.2011.10.119  0.38
2012 Dou D, Mandadapu SR, Alliston KR, Kim Y, Chang KO, Groutas WC. Cyclosulfamide-based derivatives as inhibitors of noroviruses. European Journal of Medicinal Chemistry. 47: 59-64. PMID 22063754 DOI: 10.1016/J.Ejmech.2011.10.019  0.65
2012 Takahashi D, Kim Y, Chang KO, Anbanandam A, Prakash O. Backbone and side-chain ¹H, ¹⁵N, and ¹³C resonance assignments of Norwalk virus protease. Biomolecular Nmr Assignments. 6: 19-21. PMID 21647610 DOI: 10.1007/S12104-011-9316-3  0.369
2011 Dou D, Tiew KC, He G, Mandadapu SR, Aravapalli S, Alliston KR, Kim Y, Chang KO, Groutas WC. Potent inhibition of Norwalk virus by cyclic sulfamide derivatives. Bioorganic & Medicinal Chemistry. 19: 5975-83. PMID 21925886 DOI: 10.1016/J.Bmc.2011.08.054  0.624
2011 Dou D, Mandadapu SR, Alliston KR, Kim Y, Chang KO, Groutas WC. Design and synthesis of inhibitors of noroviruses by scaffold hopping. Bioorganic & Medicinal Chemistry. 19: 5749-55. PMID 21893416 DOI: 10.1016/J.Bmc.2011.08.032  0.645
2011 Tiew KC, He G, Aravapalli S, Mandadapu SR, Gunnam MR, Alliston KR, Lushington GH, Kim Y, Chang KO, Groutas WC. Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease. Bioorganic & Medicinal Chemistry Letters. 21: 5315-9. PMID 21802286 DOI: 10.1016/J.Bmcl.2011.07.016  0.703
2011 Takahashi D, Kim Y, Chang K, Anbanandam A, Prakash O. Solution Structure Determination of Norwalk Virus 3C-Like Cysteine Protease Biophysical Journal. 100: 605a-606a. DOI: 10.1016/J.Bpj.2010.12.3486  0.332
2010 Kim Y, Narayanan S, Chang KO. Inhibition of influenza virus replication by plant-derived isoquercetin. Antiviral Research. 88: 227-35. PMID 20826184 DOI: 10.1016/J.Antiviral.2010.08.016  0.305
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