Kai W. Wucherpfennig - Publications

Affiliations: 
Cancer Immunology and AIDS Dana-Farber Cancer Research Institute 
Area:
T Cell Biology and Cancer Immunology
Website:
http://www.fas.harvard.edu/~biophys/Kai_W_Wucherpfennig.htm

145 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, ... ... Wucherpfennig KW, et al. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science (New York, N.Y.). 363: 993-998. PMID 30819965 DOI: 10.1126/science.aat7186  0.44
2014 Sollid LM, Pos W, Wucherpfennig KW. Molecular mechanisms for contribution of MHC molecules to autoimmune diseases. Current Opinion in Immunology. 31: 24-30. PMID 25216261 DOI: 10.1016/j.coi.2014.08.005  1
2014 Cremasco V, Woodruff MC, Onder L, Cupovic J, Nieves-Bonilla JM, Schildberg FA, Chang J, Cremasco F, Harvey CJ, Wucherpfennig K, Ludewig B, Carroll MC, Turley SJ. B cell homeostasis and follicle confines are governed by fibroblastic reticular cells. Nature Immunology. 15: 973-81. PMID 25151489 DOI: 10.1038/ni.2965  1
2014 Zhou P, Wucherpfennig KW. Discovering cancer immunotherapy targets in vivo. Oncoimmunology. 3: e28500. PMID 25050218 DOI: 10.4161/onci.28500  1
2014 Bettini ML, Guy C, Dash P, Vignali KM, Hamm DE, Dobbins J, Gagnon E, Thomas PG, Wucherpfennig KW, Vignali DA. Membrane association of the CD3ε signaling domain is required for optimal T cell development and function. Journal of Immunology (Baltimore, Md. : 1950). 193: 258-67. PMID 24899501 DOI: 10.4049/jimmunol.1400322  1
2014 Kardava L, Moir S, Shah N, Wang W, Wilson R, Buckner CM, Santich BH, Kim LJ, Spurlin EE, Nelson AK, Wheatley AK, Harvey CJ, McDermott AB, Wucherpfennig KW, Chun TW, et al. Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals. The Journal of Clinical Investigation. 124: 3252-62. PMID 24892810 DOI: 10.1172/JCI74351  1
2014 Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, Dobbins J, Ozkan E, Davis MM, Wucherpfennig KW, Garcia KC. Deconstructing the peptide-MHC specificity of T cell recognition. Cell. 157: 1073-87. PMID 24855945 DOI: 10.1016/j.cell.2014.03.047  1
2014 Choudhuri K, Llodrá J, Roth EW, Tsai J, Gordo S, Wucherpfennig KW, Kam LC, Stokes DL, Dustin ML. Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse. Nature. 507: 118-23. PMID 24487619 DOI: 10.1038/nature12951  1
2014 Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, ... ... Wucherpfennig KW, et al. In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 506: 52-7. PMID 24476824 DOI: 10.1038/nature12988  1
2013 Sethi DK, Gordo S, Schubert DA, Wucherpfennig KW. Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop. Nature Communications. 4: 2623. PMID 24136005 DOI: 10.1038/ncomms3623  1
2013 Harvey CJ, Wucherpfennig KW. Cracking the code of human T-cell immunity. Nature Biotechnology. 31: 609-10. PMID 23839145 DOI: 10.1038/nbt.2626  1
2013 Pos W, Sethi DK, Wucherpfennig KW. Mechanisms of peptide repertoire selection by HLA-DM. Trends in Immunology. 34: 495-501. PMID 23835076 DOI: 10.1016/j.it.2013.06.002  1
2013 Reardon DA, Wucherpfennig KW, Freeman G, Wu CJ, Chiocca EA, Wen PY, Curry WT, Mitchell DA, Fecci PE, Sampson JH, Dranoff G. An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma. Expert Review of Vaccines. 12: 597-615. PMID 23750791 DOI: 10.1586/erv.13.41  1
2013 Torres AJ, Contento RL, Gordo S, Wucherpfennig KW, Love JC. Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells. Lab On a Chip. 13: 90-9. PMID 23070211 DOI: 10.1039/c2lc40869d  1
2012 Pos W, Sethi DK, Call MJ, Schulze MS, Anders AK, Pyrdol J, Wucherpfennig KW. Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection. Cell. 151: 1557-68. PMID 23260142 DOI: 10.1016/j.cell.2012.11.025  1
2012 Gagnon E, Schubert DA, Gordo S, Chu HH, Wucherpfennig KW. Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain. The Journal of Experimental Medicine. 209: 2423-39. PMID 23166358 DOI: 10.1084/jem.20120790  1
2012 Janas MM, Wang B, Harris AS, Aguiar M, Shaffer JM, Subrahmanyam YV, Behlke MA, Wucherpfennig KW, Gygi SP, Gagnon E, Novina CD. Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins. Rna (New York, N.Y.). 18: 2041-55. PMID 23019594 DOI: 10.1261/rna.035675.112  1
2012 Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, ... ... Wucherpfennig KW, et al. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 37: 276-89. PMID 22884313 DOI: 10.1016/j.immuni.2012.05.022  1
2012 Angin M, King M, Altfeld M, Walker BD, Wucherpfennig KW, Addo MM. Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers. Aids (London, England). 26: 2112-5. PMID 22874519 DOI: 10.1097/QAD.0b013e328358cc75  1
2012 Schubert DA, Gordo S, Sabatino JJ, Vardhana S, Gagnon E, Sethi DK, Seth NP, Choudhuri K, Reijonen H, Nepom GT, Evavold BD, Dustin ML, Wucherpfennig KW. Self-reactive human CD4 T cell clones form unusual immunological synapses. The Journal of Experimental Medicine. 209: 335-52. PMID 22312112 DOI: 10.1084/jem.20111485  1
2012 Schulze MS, Wucherpfennig KW. The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway. Current Opinion in Immunology. 24: 105-11. PMID 22138314 DOI: 10.1016/j.coi.2011.11.004  1
2012 Janas MM, Wang B, Harris AS, Aguiar M, Shaffer JM, Subrahmanyam YVBK, Behlke MA, Wucherpfennig KW, Gygi SP, Gagnon E, Novina CD. Alternative RISC assembly: Binding and repression of microRNA-mRNA duplexes by human Ago proteins (RNA (2012) 18, (2041-2055)) Rna. 18: 2345.  1
2011 Peters A, Pitcher LA, Sullivan JM, Mitsdoerffer M, Acton SE, Franz B, Wucherpfennig K, Turley S, Carroll MC, Sobel RA, Bettelli E, Kuchroo VK. Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity. 35: 986-96. PMID 22177922 DOI: 10.1016/j.immuni.2011.10.015  1
2011 Wucherpfennig KW, Noelle RJ. Autoimmune diseases have been the focus of intense research efforts. Current Opinion in Immunology. 23: 699-701. PMID 22056155 DOI: 10.1016/j.coi.2011.10.003  1
2011 Wen F, Sethi DK, Wucherpfennig KW, Zhao H. Cell surface display of functional human MHC class II proteins: yeast display versus insect cell display. Protein Engineering, Design & Selection : Peds. 24: 701-9. PMID 21752831 DOI: 10.1093/protein/gzr035  1
2011 Franz B, May KF, Dranoff G, Wucherpfennig K. Ex vivo characterization and isolation of rare memory B cells with antigen tetramers. Blood. 118: 348-57. PMID 21551230 DOI: 10.1182/blood-2011-03-341917  1
2011 Lv H, Havari E, Pinto S, Gottumukkala RV, Cornivelli L, Raddassi K, Matsui T, Rosenzweig A, Bronson RT, Smith R, Fletcher AL, Turley SJ, Wucherpfennig K, Kyewski B, Lipes MA. Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans. The Journal of Clinical Investigation. 121: 1561-73. PMID 21436590 DOI: 10.1172/JCI44583  1
2011 Li S, Moffett HF, Lu J, Werner L, Zhang H, Ritz J, Neuberg D, Wucherpfennig KW, Brown JR, Novina CD. MicroRNA expression profiling identifies activated B cell status in chronic lymphocytic leukemia cells. Plos One. 6: e16956. PMID 21408091 DOI: 10.1371/journal.pone.0016956  1
2011 Wucherpfennig KW, Sethi D. T cell receptor recognition of self and foreign antigens in the induction of autoimmunity. Seminars in Immunology. 23: 84-91. PMID 21306912 DOI: 10.1016/j.smim.2011.01.007  1
2011 Sethi DK, Schubert DA, Anders AK, Heroux A, Bonsor DA, Thomas CP, Sundberg EJ, Pyrdol J, Wucherpfennig KW. A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC. The Journal of Experimental Medicine. 208: 91-102. PMID 21199956 DOI: 10.1084/jem.20100725  1
2011 Anders AK, Call MJ, Schulze MS, Fowler KD, Schubert DA, Seth NP, Sundberg EJ, Wucherpfennig KW. HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide. Nature Immunology. 12: 54-61. PMID 21131964 DOI: 10.1038/ni.1967  1
2010 Wucherpfennig KW. The first structures of T cell receptors bound to peptide-MHC. Journal of Immunology (Baltimore, Md. : 1950). 185: 6391-3. PMID 21084667 DOI: 10.4049/jimmunol.1090110  1
2010 Call ME, Wucherpfennig KW, Chou JJ. The structural basis for intramembrane assembly of an activating immunoreceptor complex. Nature Immunology. 11: 1023-9. PMID 20890284 DOI: 10.1038/ni.1943  1
2010 Gagnon E, Xu C, Yang W, Chu HH, Call ME, Chou JJ, Wucherpfennig KW. Response multilayered control of T cell receptor phosphorylation. Cell. 142: 669-71. PMID 20813252 DOI: 10.1016/j.cell.2010.08.019  1
2010 Wucherpfennig KW, Gagnon E, Call MJ, Huseby ES, Call ME. Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling. Cold Spring Harbor Perspectives in Biology. 2: a005140. PMID 20452950 DOI: 10.1101/cshperspect.a005140  1
2010 Yi W, Seth NP, Martillotti T, Wucherpfennig KW, Sant'Angelo DB, Denzin LK. Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. The Journal of Clinical Investigation. 120: 1324-36. PMID 20200448 DOI: 10.1172/JCI40220  1
2009 Wucherpfennig KW, Gagnon E. Positively selecting peptides: their job does not end in the thymus. Nature Immunology. 10: 1143-4. PMID 19841646 DOI: 10.1038/ni1109-1143  1
2009 Wucherpfennig KW, Call MJ, Deng L, Mariuzza R. Structural alterations in peptide-MHC recognition by self-reactive T cell receptors. Current Opinion in Immunology. 21: 590-5. PMID 19699075 DOI: 10.1016/j.coi.2009.07.008  1
2009 McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, ... ... Wucherpfennig KW, et al. Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. Journal of Immunology (Baltimore, Md. : 1950). 183: 4067-76. PMID 19687098 DOI: 10.4049/jimmunol.0801888  1
2009 Call MJ, Xing X, Cuny GD, Seth NP, Altmann DM, Fugger L, Krogsgaard M, Stein RL, Wucherpfennig KW. In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. Journal of Immunology (Baltimore, Md. : 1950). 182: 6342-52. PMID 19414787 DOI: 10.4049/jimmunol.0803464  1
2009 Perone MJ, Bertera S, Shufesky WJ, Divito SJ, Montecalvo A, Mathers AR, Larregina AT, Pang M, Seth N, Wucherpfennig KW, Trucco M, Baum LG, Morelli AE. Suppression of autoimmune diabetes by soluble galectin-1. Journal of Immunology (Baltimore, Md. : 1950). 182: 2641-53. PMID 19234158 DOI: 10.4049/jimmunol.0800839  1
2008 Xu C, Gagnon E, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ, Wucherpfennig KW. Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. Cell. 135: 702-13. PMID 19013279 DOI: 10.1016/j.cell.2008.09.044  1
2008 McLaughlin KA, Wucherpfennig KW. B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases. Advances in Immunology. 98: 121-49. PMID 18772005 DOI: 10.1016/S0065-2776(08)00404-5  1
2008 Bowen DG, Shoukry NH, Grakoui A, Fuller MJ, Cawthon AG, Dong C, Hasselschwert DL, Brasky KM, Freeman GJ, Seth NP, Wucherpfennig KW, Houghton M, Walker CM. Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. Journal of Virology. 82: 5109-14. PMID 18337576 DOI: 10.1128/JVI.00060-08  1
2008 Verginis P, McLaughlin KA, Wucherpfennig KW, von Boehmer H, Apostolou I. Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Proceedings of the National Academy of Sciences of the United States of America. 105: 3479-84. PMID 18299571 DOI: 10.1073/pnas.0800149105  1
2007 Nose H, Kubota R, Seth NP, Goon PK, Tanaka Y, Izumo S, Usuku K, Ohara Y, Wucherpfennig KW, Bangham CR, Osame M, Saito M. Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide. The Journal of Infectious Diseases. 196: 1761-72. PMID 18190256 DOI: 10.1086/522966  1
2007 Call ME, Wucherpfennig KW. Common themes in the assembly and architecture of activating immune receptors. Nature Reviews. Immunology. 7: 841-50. PMID 17960150 DOI: 10.1038/nri2186  1
2007 Grotenbreg GM, Nicholson MJ, Fowler KD, Wilbuer K, Octavio L, Yang M, Chakraborty AK, Ploegh HL, Wucherpfennig KW. Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association. The Journal of Biological Chemistry. 282: 21425-36. PMID 17525157 DOI: 10.1074/jbc.M702844200  1
2007 Lu L, Ikizawa K, Hu D, Werneck MB, Wucherpfennig KW, Cantor H. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity. 26: 593-604. PMID 17509909 DOI: 10.1016/j.immuni.2007.03.017  1
2007 Garibyan L, Lobito AA, Siegel RM, Call ME, Wucherpfennig KW, Geha RS. Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). The Journal of Clinical Investigation. 117: 1550-7. PMID 17492055 DOI: 10.1172/JCI31023  1
2007 Wucherpfennig KW, Allen PM, Celada F, Cohen IR, De Boer R, Garcia KC, Goldstein B, Greenspan R, Hafler D, Hodgkin P, Huseby ES, Krakauer DC, Nemazee D, Perelson AS, Pinilla C, et al. Polyspecificity of T cell and B cell receptor recognition. Seminars in Immunology. 19: 216-24. PMID 17398114 DOI: 10.1016/j.smim.2007.02.012  1
2007 Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, Bäckström BT, Sobel RA, Wucherpfennig KW, Strom TB, Oukka M, Kuchroo VK. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nature Medicine. 13: 423-31. PMID 17384649 DOI: 10.1038/nm1564  1
2007 Moza B, Varma AK, Buonpane RA, Zhu P, Herfst CA, Nicholson MJ, Wilbuer AK, Seth NP, Wucherpfennig KW, McCormick JK, Kranz DM, Sundberg EJ. Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1. The Embo Journal. 26: 1187-97. PMID 17268555 DOI: 10.1038/sj.emboj.7601531  1
2007 O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, ... ... Wucherpfennig KW, et al. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nature Medicine. 13: 211-7. PMID 17237795 DOI: 10.1038/nm1488  1
2007 Wucherpfennig KW. The structure and function of antigen receptors Seminars in Immunology. 19: 215. DOI: 10.1016/j.smim.2007.04.004  1
2006 Call ME, Schnell JR, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW. The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell. 127: 355-68. PMID 17055436 DOI: 10.1016/j.cell.2006.08.044  1
2006 Xu C, Call ME, Wucherpfennig KW. A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor. The Journal of Biological Chemistry. 281: 36977-84. PMID 17023417 DOI: 10.1074/jbc.M607164200  1
2006 Ulsenheimer A, Lucas M, Seth NP, Tilman Gerlach J, Gruener NH, Loughry A, Pape GR, Wucherpfennig KW, Diepolder HM, Klenerman P. Transient immunological control during acute hepatitis C virus infection: ex vivo analysis of helper T-cell responses. Journal of Viral Hepatitis. 13: 708-14. PMID 16970603 DOI: 10.1111/j.1365-2893.2006.00747.x  1
2006 Feng J, Call ME, Wucherpfennig KW. The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site. Plos Biology. 4: e142. PMID 16623599 DOI: 10.1371/journal.pbio.0040142  1
2006 Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW. Small molecules that enhance the catalytic efficiency of HLA-DM. Journal of Immunology (Baltimore, Md. : 1950). 176: 4208-20. PMID 16547258  1
2005 Wucherpfennig KW. The structural interactions between T cell receptors and MHC-peptide complexes place physical limits on self-nonself discrimination. Current Topics in Microbiology and Immunology. 296: 19-37. PMID 16329190  1
2005 Seth N, Kaufmann D, Lahey T, Rosenberg ES, Wucherpfennig KW. Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication. Journal of Immunology (Baltimore, Md. : 1950). 175: 6948-58. PMID 16272355  1
2005 Reddy J, Waldner H, Zhang X, Illes Z, Wucherpfennig KW, Sobel RA, Kuchroo VK. Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 175: 5591-5. PMID 16237044  1
2005 Nicholson MJ, Hahn M, Wucherpfennig KW. Unusual features of self-peptide/MHC binding by autoimmune T cell receptors. Immunity. 23: 351-60. PMID 16226501 DOI: 10.1016/j.immuni.2005.09.009  1
2005 O'Connor KC, Appel H, Bregoli L, Call ME, Catz I, Chan JA, Moore NH, Warren KG, Wong SJ, Hafler DA, Wucherpfennig KW. Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. Journal of Immunology (Baltimore, Md. : 1950). 175: 1974-82. PMID 16034142  1
2005 Garrity D, Call ME, Feng J, Wucherpfennig KW. The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure. Proceedings of the National Academy of Sciences of the United States of America. 102: 7641-6. PMID 15894612 DOI: 10.1073/pnas.0502439102  1
2005 Feng J, Garrity D, Call ME, Moffett H, Wucherpfennig KW. Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors. Immunity. 22: 427-38. PMID 15845448 DOI: 10.1016/j.immuni.2005.02.005  1
2005 Hahn M, Nicholson MJ, Pyrdol J, Wucherpfennig KW. Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor. Nature Immunology. 6: 490-6. PMID 15821740 DOI: 10.1038/ni1187  1
2005 Call ME, Wucherpfennig KW. The T cell receptor: critical role of the membrane environment in receptor assembly and function. Annual Review of Immunology. 23: 101-25. PMID 15771567 DOI: 10.1146/annurev.immunol.23.021704.115625  1
2004 Appel H, Kuon W, Kuhne M, Hülsmeyer M, Kollnberger S, Kuhlmann S, Weiss E, Zeitz M, Wucherpfennig K, Bowness P, Sieper J. The solvent-inaccessible Cys67 residue of HLA-B27 contributes to T cell recognition of HLA-B27/peptide complexes Journal of Immunology. 173: 6564-6573. PMID 15557146  1
2004 Reddy J, Illes Z, Zhang X, Encinas J, Pyrdol J, Nicholson L, Sobel RA, Wucherpfennig KW, Kuchroo VK. Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America. 101: 15434-9. PMID 15492218 DOI: 10.1073/pnas.0404444101  1
2004 Haining WN, Evans JW, Seth NP, Callaway GD, Wucherpfennig KW, Nadler LM, Guinan EC. Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation. British Journal of Haematology. 127: 322-5. PMID 15491293 DOI: 10.1111/j.1365-2141.2004.05204.x  1
2004 Tian C, Bagley J, Cretin N, Seth N, Wucherpfennig KW, Iacomini J. Prevention of type 1 diabetes by gene therapy. The Journal of Clinical Investigation. 114: 969-78. PMID 15467836 DOI: 10.1172/JCI22103  1
2004 Ferlin WG, Mougneau E, Hugues S, Appel H, Jang MH, Cazareth J, Beaudoin L, Schricke C, Lehuen A, Wucherpfennig KW, Glaichenhaus N. Self-peptides that bind with low affinity to the diabetes-associated I-A(g7) molecule readily induce T cell tolerance in non-obese diabetic mice. European Journal of Immunology. 34: 2656-63. PMID 15368281 DOI: 10.1002/eji.200425413  1
2004 Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK, Hafler DA. Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. Journal of Immunology (Baltimore, Md. : 1950). 173: 1689-98. PMID 15265898  1
2004 Havari E, Lennon-Dumenil AM, Klein L, Neely D, Taylor JA, McInerney MF, Wucherpfennig KW, Lipes MA. Expression of the B7.1 costimulatory molecule on pancreatic beta cells abrogates the requirement for CD4 T cells in the development of type 1 diabetes. Journal of Immunology (Baltimore, Md. : 1950). 173: 787-96. PMID 15240665  1
2004 Call ME, Pyrdol J, Wucherpfennig KW. Stoichiometry of the T-cell receptor-CD3 complex and key intermediates assembled in the endoplasmic reticulum. The Embo Journal. 23: 2348-57. PMID 15152191 DOI: 10.1038/sj.emboj.7600245  1
2004 Panoutsakopoulou V, Huster KM, McCarty N, Feinberg E, Wang R, Wucherpfennig KW, Cantor H. Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes. The Journal of Clinical Investigation. 113: 1218-24. PMID 15085201 DOI: 10.1172/JCI20772  1
2004 Call ME, Wucherpfennig KW. Molecular mechanisms for the assembly of the T cell receptor-CD3 complex. Molecular Immunology. 40: 1295-305. PMID 15072848 DOI: 10.1016/j.molimm.2003.11.017  1
2004 Wucherpfennig KW. T cell receptor crossreactivity as a general property of T cell recognition. Molecular Immunology. 40: 1009-17. PMID 15036904 DOI: 10.1016/j.molimm.2003.11.003  1
2004 Taylor JA, Havari E, McInerney MF, Bronson R, Wucherpfennig KW, Lipes MA. A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8. Journal of Immunology (Baltimore, Md. : 1950). 172: 2651-8. PMID 14764740  1
2004 Wucherpfennig KW. Presentation of a self-peptide in two distinct conformations by a disease-associated HLA-B27 subtype. The Journal of Experimental Medicine. 199: 151-4. PMID 14734520 DOI: 10.1084/jem.20032050  1
2004 Wucherpfennig KW. Implications of T Cell Receptor Crossreactivity for the Pathogenesis of Autoimmune Diseases Infection and Autoimmunity, 2nd Edition. 7-18. DOI: 10.1016/B978-044451271-0.50002-8  1
2003 Wucherpfennig KW. MHC-linked susceptibility to type 1 diabetes: a structural perspective. Annals of the New York Academy of Sciences. 1005: 119-27. PMID 14679046 DOI: 10.1196/annals.1288.013  1
2003 Berretta F, Butler RH, Diaz G, Sanarico N, Arroyo J, Fraziano M, Aichinger G, Wucherpfennig KW, Colizzi V, Saltini C, Amicosante M. Detailed analysis of the effects of Glu/Lys beta69 human leukocyte antigen-DP polymorphism on peptide-binding specificity. Tissue Antigens. 62: 459-71. PMID 14617029 DOI: 10.1046/j.1399-0039.2003.00131.x  1
2003 Jang MH, Seth NP, Wucherpfennig KW. Ex vivo analysis of thymic CD4 T cells in nonobese diabetic mice with tetramers generated from I-A(g7)/class II-associated invariant chain peptide precursors. Journal of Immunology (Baltimore, Md. : 1950). 171: 4175-86. PMID 14530340  1
2003 Day CL, Seth NP, Lucas M, Appel H, Gauthier L, Lauer GM, Robbins GK, Szczepiorkowski ZM, Casson DR, Chung RT, Bell S, Harcourt G, Walker BD, Klenerman P, Wucherpfennig KW. Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. The Journal of Clinical Investigation. 112: 831-42. PMID 12975468 DOI: 10.1172/JCI18509  1
2003 Maecker B, Sherr DH, Vonderheide RH, von Bergwelt-Baildon MS, Hirano N, Anderson KS, Xia Z, Butler MO, Wucherpfennig KW, O'Hara C, Cole G, Kwak SS, Ramstedt U, Tomlinson AJ, Chicz RM, et al. The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. Blood. 102: 3287-94. PMID 12869499 DOI: 10.1182/blood-2003-05-1374  1
2003 O'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW, Hafler DA. Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions. Journal of Neuroimmunology. 136: 140-8. PMID 12620653 DOI: 10.1016/S0165-5728(03)00002-X  1
2003 Reddy J, Bettelli E, Nicholson L, Waldner H, Jang MH, Wucherpfennig KW, Kuchroo VK. Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers. Journal of Immunology (Baltimore, Md. : 1950). 170: 870-7. PMID 12517952  1
2002 Call ME, Pyrdol J, Wiedmann M, Wucherpfennig KW. The organizing principle in the formation of the T cell receptor-CD3 complex. Cell. 111: 967-79. PMID 12507424 DOI: 10.1016/S0092-8674(02)01194-7  1
2002 Belmares MP, Busch R, Wucherpfennig KW, McConnell HM, Mellins ED. Structural factors contributing to DM susceptibility of MHC class II/peptide complexes. Journal of Immunology (Baltimore, Md. : 1950). 169: 5109-17. PMID 12391227  1
2002 Lang HL, Jacobsen H, Ikemizu S, Andersson C, Harlos K, Madsen L, Hjorth P, Sondergaard L, Svejgaard A, Wucherpfennig K, Stuart DI, Bell JI, Jones EY, Fugger L. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nature Immunology. 3: 940-3. PMID 12244309 DOI: 10.1038/ni835  1
2002 Wucherpfennig KW. Infectious triggers for inflammatory neurological diseases. Nature Medicine. 8: 455-7. PMID 11984586 DOI: 10.1038/nm0502-455  1
2002 von Bergwelt-Baildon MS, Vonderheide RH, Maecker B, Hirano N, Anderson KS, Butler MO, Xia Z, Zeng WY, Wucherpfennig KW, Nadler LM, Schultze JL. Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application. Blood. 99: 3319-25. PMID 11964299 DOI: 10.1182/blood.V99.9.3319  1
2001 Vonderheide RH, Schultze JL, Anderson KS, Maecker B, Butler MO, Xia Z, Kuroda MJ, von Bergwelt-Baildon MS, Bedor MM, Hoar KM, Schnipper DR, Brooks MW, Letvin NL, Stephans KF, Wucherpfennig KW, et al. Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals. Cancer Research. 61: 8366-70. PMID 11731409  1
2001 Wucherpfennig KW. Insights into autoimmunity gained from structural analysis of MHC-peptide complexes. Current Opinion in Immunology. 13: 650-6. PMID 11677085 DOI: 10.1016/S0952-7915(01)00274-6  1
2001 Wucherpfennig KW. Mechanisms for the induction of autoimmunity by infectious agents. The Journal of Clinical Investigation. 108: 1097-104. PMID 11602615 DOI: 10.1172/JCI14235  1
2001 Wucherpfennig KW, Eisenbarth GS. Type 1 diabetes. Nature Immunology. 2: 767-8. PMID 11526380 DOI: 10.1038/ni0901-767  1
2001 Panoutsakopoulou V, Sanchirico ME, Huster KM, Jansson M, Granucci F, Shim DJ, Wucherpfennig KW, Cantor H. Analysis of the relationship between viral infection and autoimmune disease. Immunity. 15: 137-47. PMID 11485745 DOI: 10.1016/S1074-7613(01)00172-8  1
2001 Lee KH, Wucherpfennig KW, Wiley DC. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nature Immunology. 2: 501-7. PMID 11376336 DOI: 10.1038/88694  1
2001 Wucherpfennig KW. Structural basis of molecular mimicry. Journal of Autoimmunity. 16: 293-302. PMID 11334495 DOI: 10.1006/jaut.2000.0499  1
2001 Appel H, Seth NP, Gauthier L, Wucherpfennig KW. Anergy induction by dimeric TCR ligands. Journal of Immunology (Baltimore, Md. : 1950). 166: 5279-85. PMID 11290814  1
2000 Yu B, Gauthier L, Hausmann DH, Wucherpfennig KW. Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes. European Journal of Immunology. 30: 2497-506. PMID 11009082 DOI: 10.1002/1521-4141(200009)30:9<2497::AID-IMMU2497>3.0.CO;2-J  1
2000 Krogsgaard M, Wucherpfennig KW, Cannella B, Hansen BE, Svejgaard A, Pyrdol J, Ditzel H, Raine C, Engberg J, Fugger L, Canella B. Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex. The Journal of Experimental Medicine. 191: 1395-412. PMID 10770805 DOI: 10.1084/jem.191.8.1395  1
2000 Appel H, Gauthier L, Pyrdol J, Wucherpfennig KW. Kinetics of T-cell receptor binding by bivalent HLA-DR. Peptide complexes that activate antigen-specific human T-cells. The Journal of Biological Chemistry. 275: 312-21. PMID 10617620 DOI: 10.1074/jbc.275.1.312  1
1999 Madsen LS, Andersson EC, Jansson L, krogsgaard M, Andersen CB, Engberg J, Strominger JL, Svejgaard A, Hjorth JP, Holmdahl R, Wucherpfennig KW, Fugger L. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nature Genetics. 23: 343-7. PMID 10610182 DOI: 10.1038/15525  1
1999 Hausmann DH, Yu B, Hausmann S, Wucherpfennig KW. pH-dependent peptide binding properties of the type I diabetes-associated I-Ag7 molecule: rapid release of CLIP at an endosomal pH. The Journal of Experimental Medicine. 189: 1723-34. PMID 10359576 DOI: 10.1084/jem.189.11.1723  1
1999 Hausmann S, Biddison WE, Smith KJ, Ding YH, Garboczi DN, Utz U, Wiley DC, Wucherpfennig KW. Peptide recognition by two HLA-A2/Tax11-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures. Journal of Immunology (Baltimore, Md. : 1950). 162: 5389-97. PMID 10228016  1
1999 Fridkis-Hareli M, Neveu JM, Robinson RA, Lane WS, Gauthier L, Wucherpfennig KW, Sela M, Strominger JL. Binding motifs of copolymer 1 to multiple sclerosis- and rheumatoid arthritis-associated HLA-DR molecules. Journal of Immunology (Baltimore, Md. : 1950). 162: 4697-704. PMID 10202010  1
1999 Hausmann S, Martin M, Gauthier L, Wucherpfennig KW. Structural features of autoreactive TCR that determine the degree of degeneracy in peptide recognition. Journal of Immunology (Baltimore, Md. : 1950). 162: 338-44. PMID 9886404  1
1998 Ufret-Vincenty RL, Quigley L, Tresser N, Pak SH, Gado A, Hausmann S, Wucherpfennig KW, Brocke S. In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis. The Journal of Experimental Medicine. 188: 1725-38. PMID 9802984 DOI: 10.1084/jem.188.9.1725  1
1998 Smith KJ, Pyrdol J, Gauthier L, Wiley DC, Wucherpfennig KW. Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein. The Journal of Experimental Medicine. 188: 1511-20. PMID 9782128 DOI: 10.1084/jem.188.8.1511  1
1998 Gauthier L, Smith KJ, Pyrdol J, Kalandadze A, Strominger JL, Wiley DC, Wucherpfennig KW. Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic protein. Proceedings of the National Academy of Sciences of the United States of America. 95: 11828-33. PMID 9751750  1
1998 Eble JA, Wucherpfennig KW, Gauthier L, Dersch P, Krukonis E, Isberg RR, Hemler ME. Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner. Biochemistry. 37: 10945-55. PMID 9692987 DOI: 10.1021/bi980175+  1
1998 Liedtke W, Cannella B, Mazzaccaro RJ, Clements JM, Miller KM, Wucherpfennig KW, Gearing AJ, Raine CS. Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. Annals of Neurology. 44: 35-46. PMID 9667591 DOI: 10.1002/ana.410440110  1
1998 Brocke S, Hausmann S, Steinman L, Wucherpfennig KW. Microbial peptides and superantigens in the pathogenesis of autoimmune diseases of the central nervous system. Seminars in Immunology. 10: 57-67. PMID 9529656 DOI: 10.1006/smim.1997.0105  1
1997 Hausmann S, Wucherpfennig KW. Activation of autoreactive T cells by peptides from human pathogens. Current Opinion in Immunology. 9: 831-8. PMID 9492986 DOI: 10.1016/S0952-7915(97)80186-0  1
1997 Warren KG, Catz I, Wucherpfennig KW. Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P85 VVHFFKNIVTP96 in chronic progressive multiple sclerosis. Journal of the Neurological Sciences. 152: 31-8. PMID 9395124 DOI: 10.1016/S0022-510X(97)00130-5  1
1997 Wucherpfennig KW, Catz I, Hausmann S, Strominger JL, Steinman L, Warren KG. Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes. The Journal of Clinical Investigation. 100: 1114-22. PMID 9276728 DOI: 10.1172/JCI119622  1
1996 Kalandadze A, Galleno M, Foncerrada L, Strominger JL, Wucherpfennig KW. Expression of recombinant HLA-DR2 molecules. Replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the assembly and secretion of soluble DR alpha beta heterodimers. The Journal of Biological Chemistry. 271: 20156-62. PMID 8702739 DOI: 10.1074/jbc.271.33.20156  1
1995 Wucherpfennig KW, Yu B, Bhol K, Monos DS, Argyris E, Karr RW, Ahmed AR, Strominger JL. Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris. Proceedings of the National Academy of Sciences of the United States of America. 92: 11935-9. PMID 8524878  1
1995 Wucherpfennig KW, Strominger JL. Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases. The Journal of Experimental Medicine. 181: 1597-601. PMID 7722439  1
1995 Wucherpfennig KW, Hafler DA, Strominger JL. Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes. Proceedings of the National Academy of Sciences of the United States of America. 92: 8896-900. PMID 7568039 DOI: 10.1073/pnas.92.19.8896  1
1995 Wucherpfennig KW, Hafler DA. A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide. Annals of the New York Academy of Sciences. 756: 241-58. PMID 7544075 DOI: 10.1111/j.1749-6632.1995.tb44522.x  1
1995 Wucherpfennig KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 80: 695-705. PMID 7534214 DOI: 10.1016/0092-8674(95)90348-8  1
1994 Wucherpfennig KW. Autoimmunity in the central nervous system: mechanisms of antigen presentation and recognition. Clinical Immunology and Immunopathology. 72: 293-306. PMID 8062444 DOI: 10.1006/clin.1994.1145  1
1994 Chung S, Wucherpfennig KW, Friedman SM, Hafler DA, Strominger JL. Functional three-domain single-chain T-cell receptors. Proceedings of the National Academy of Sciences of the United States of America. 91: 12654-8. PMID 7809095 DOI: 10.1073/pnas.91.26.12654  1
1994 Wucherpfennig KW, Zhang J, Witek C, Matsui M, Modabber Y, Ota K, Hafler DA. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. Journal of Immunology (Baltimore, Md. : 1950). 152: 5581-92. PMID 7514641  1
1994 Wucherpfennig KW, Sette A, Southwood S, Oseroff C, Matsui M, Strominger JL, Hafler DA. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. The Journal of Experimental Medicine. 179: 279-90. PMID 7505801 DOI: 10.1084/jem.179.1.279  1
1993 Wucherpfennig KW, Liao YJ, Prendergast M, Prendergast J, Hafler DA, Strominger JL. Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells. The Journal of Experimental Medicine. 177: 425-32. PMID 8093893  1
1992 Wucherpfennig KW, Höllsberg P, Richardson JH, Benjamin D, Hafler DA. T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. Proceedings of the National Academy of Sciences of the United States of America. 89: 2110-4. PMID 1549569  1
1992 Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA. Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions. Proceedings of the National Academy of Sciences of the United States of America. 89: 4588-92. PMID 1374907  1
1992 Höllsberg P, Wucherpfennig KW, Ausubel LJ, Calvo V, Bierer BE, Hafler DA. Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. Journal of Immunology (Baltimore, Md. : 1950). 148: 3256-63. PMID 1374452  1
1992 Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA. T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions. The Journal of Experimental Medicine. 175: 993-1002. PMID 1348083  1
1991 Lee SJ, Wucherpfennig KW, Brod SA, Benjamin D, Weiner HL, Hafler DA. Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis. Annals of Neurology. 29: 33-40. PMID 1847614 DOI: 10.1002/ana.410290109  1
1991 Lauer K, Hafler DA, Wucherpfennig KW, Brod SA, Weiner HL. T-cell receptor biology and multiple sclerosis [2] Annals of Neurology. 30: 623-624. PMID 1789690  1
1991 Hafler DA, Matsui M, Wucherpfennig KW, Ota K, Weiner HL. The potential of restricted T cell recognition of myelin basic protein epitopes in the therapy of multiple sclerosis. Annals of the New York Academy of Sciences. 636: 251-65. PMID 1724362  1
1991 Wucherpfennig KW, Weiner HL, Hafler DA. T-cell recognition of myelin basic protein. Immunology Today. 12: 277-82. PMID 1716903 DOI: 10.1016/0167-5699(91)90126-E  1
1991 Balk SP, Ebert EC, Blumenthal RL, McDermott FV, Wucherpfennig KW, Landau SB, Blumberg RS. Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes. Science (New York, N.Y.). 253: 1411-5. PMID 1716785  1
1990 Wucherpfennig KW, Weiner HL. Immunologic mechanisms in chronic demyelinating diseases of the central and peripheral nervous system. Research Publications - Association For Research in Nervous and Mental Disease. 68: 105-16. PMID 2158131  1
1990 Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL, Hafler DA. Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science (New York, N.Y.). 248: 1016-9. PMID 1693015  1
1989 Richardson JH, Wucherpfennig KW, Endo N, Rudge P, Dalgleish AG, Hafler DA. PCR analysis of DNA from multiple sclerosis patients for the presence of HTLV-I (II) Science. 246: 821-823. PMID 2683085  1
1989 Bangham CRM, Nightingale S, Cruickshank JK, Daenke S, Richardson JH, Wucherpfennig KW, Endo N, Rudge P, Dalgleish AG, Hafler DA, Reddy EP. PCR analysis of DNA from multiple sclerosis patients for the presence of HTLV-I Science. 246: 821-824.  1
1988 Schluesener HJ, Wucherpfennig KW, Weiner HL. Gene activation during experimental allergic encephalomyelitis. Cloning of new cDNAs. Annals of the New York Academy of Sciences. 540: 264-5. PMID 3207255  1
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