Penelope Hallett - Related publications

2002-2006 Neurology Harvard Medical School, Boston, MA, United States 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Mustafa R, Rawas C, Mannal N, Kreiner G, Spittau B, Kamińska K, Yilmaz R, Pötschke C, Kirsch J, Liss B, Tucker KL, Parlato R. Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress. Antioxidants (Basel, Switzerland). 10. PMID 34439532 DOI: 10.3390/antiox10081284   
2021 Bastioli G, Regoni M, Cazzaniga F, De Luca CMG, Bistaffa E, Zanetti L, Moda F, Valtorta F, Sassone J. Animal Models of Autosomal Recessive Parkinsonism. Biomedicines. 9. PMID 34356877 DOI: 10.3390/biomedicines9070812   
2021 Mirzaei S, Kulkarni K, Zhou K, Crack PJ, Aguilar MI, Finkelstein DI, Forsythe JS. Biomaterial Strategies for Restorative Therapies in Parkinson's Disease. Acs Chemical Neuroscience. PMID 34634903 DOI: 10.1021/acschemneuro.1c00484   
2021 Harris KL, Mason SL, Vallin B, Barker RA. Reduced expression of dopamine D2 receptors on astrocytes in R6/1 HD mice and HD post-mortem tissue. Neuroscience Letters. 136289. PMID 34637857 DOI: 10.1016/j.neulet.2021.136289   
2021 Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, et al. A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons. Elife. 10. PMID 34550070 DOI: 10.7554/eLife.69795   
2021 Hsu YL, Hung HS, Tsai CW, Liu SP, Chiang YT, Kuo YH, Shyu WC, Lin SZ, Fu RH. Peiminine Reduces ARTS-Mediated Degradation of XIAP by Modulating the PINK1/Parkin Pathway to Ameliorate 6-Hydroxydopamine Toxicity and α-Synuclein Accumulation in Parkinson's Disease Models In Vivo and In Vitro. International Journal of Molecular Sciences. 22. PMID 34638579 DOI: 10.3390/ijms221910240   
2021 Holanda VAD, Didonet JJ, Costa MBB, do Nascimento Rangel AH, da Silva ED, Gavioli EC. Neuropeptide S Receptor as an Innovative Therapeutic Target for Parkinson Disease. Pharmaceuticals (Basel, Switzerland). 14. PMID 34451872 DOI: 10.3390/ph14080775   
2021 Filograna R, Lee S, Tiklova K, Mennuni M, Jonsson V, Ringnér M, Gillberg L, Sopova E, Shupliakov O, Koolmeister C, Olson L, Perlmann T, Larsson NG. Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response. Plos Genetics. 17: e1009822. PMID 34570766 DOI: 10.1371/journal.pgen.1009822   
2021 Shen Y, Cui X, Xu N, Hu Y, Zhang Z. lncRNA PART1 mitigates MPP-induced neuronal injury in SH-SY5Y cells via micRNA-106b-5p/MCL1 axis. American Journal of Translational Research. 13: 8897-8908. PMID 34540003   
2021 Thomas MH, Gui Y, Garcia P, Karout M, Gomez Ramos B, Jaeger C, Michelucci A, Gaigneaux A, Kollmus H, Centeno A, Schughart K, Balling R, Mittelbronn M, Nadeau JH, Sauter T, et al. Quantitative trait locus mapping identifies a locus linked to striatal dopamine and points to collagen IV alpha-6 chain (COL4A6) as a novel regulator of striatal axonal branching in mice. Genes, Brain, and Behavior. e12769. PMID 34453370 DOI: 10.1111/gbb.12769   
2021 Barker RA, Björklund A, Frucht SJ, Svendsen CN. Stem Cell-Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease? Journal of Parkinson's Disease. 11: 909-917. PMID 34334425 DOI: 10.3233/JPD-219008   
2021 Christmann A, Gries M, Scholz P, Stahr PL, Law JKY, Schulte S, Martin M, Lilischkis R, Ingebrandt S, Keck CM, Schäfer KH. The antioxidant Rutin counteracts the pathological impact of -synuclein on the enteric nervous system . Biological Chemistry. PMID 34582634 DOI: 10.1515/hsz-2021-0259   
2021 Tamilanban T, Manasa K, Chitra V. In silico docking of Novel Phytoalkaloid Camalexin in the Management of Benomyl Induced Parkinson's disease and its In vivo Evaluation by Zebrafish Model. Cns & Neurological Disorders Drug Targets. PMID 34477539 DOI: 10.2174/1871527320666210903091447   
2021 Haque ME, Akther M, Azam S, Kim IS, Lin Y, Lee YH, Choi DK. Targeting α-synuclein aggregation and its role in mitochondrial dysfunction in Parkinson's disease. British Journal of Pharmacology. PMID 34528272 DOI: 10.1111/bph.15684   
2021 Fieblinger T. Striatal Control of Movement: A Role for New Neuronal (Sub-) Populations? Frontiers in Human Neuroscience. 15: 697284. PMID 34354577 DOI: 10.3389/fnhum.2021.697284   
2021 Rahul, Siddique Y. Neurodegenerative disorders and the current state, pathophysiology and management of Parkinson's disease. Cns & Neurological Disorders Drug Targets. PMID 34477534 DOI: 10.2174/1871527320666210903101841   
2021 Chetia Phukan B, Dutta A, Deb S, Saikia R, Mazumder MK, Paul R, Bhattacharya P, Sandhir R, Borah A. Garcinol blocks motor behavioural deficits by providing dopaminergic neuroprotection in MPTP mouse model of Parkinson's disease: involvement of anti-inflammatory response. Experimental Brain Research. PMID 34633467 DOI: 10.1007/s00221-021-06237-y   
2021 Giuliano C, Francavilla M, Ongari G, Petese A, Ghezzi C, Rossini N, Blandini F, Cerri S. Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson's Disease. International Journal of Molecular Sciences. 22. PMID 34445626 DOI: 10.3390/ijms22168920   
2021 Lerner S, Eilam R, Adler L, Baruteau J, Kreiser T, Tsoory M, Brandis A, Mehlman T, Ryten M, Botia JA, Ruiz SG, Garcia AC, Dionisi-Vici C, Ranucci G, Spada M, ... , et al. ASL expression in ALDH1A1 neurons in the substantia nigra metabolically contributes to neurodegenerative phenotype. Human Genetics. PMID 34417872 DOI: 10.1007/s00439-021-02345-5   
2021 Chung SJ, Lee PH, Sohn YH, Kim YJ. Glucocerebrosidase Mutations and Motor Reserve in Parkinson's Disease. Journal of Parkinson's Disease. PMID 34459414 DOI: 10.3233/JPD-212758   
2021 Ren C, Wang F, He KJ, Zhang YT, Li LX, Zhang JB, Chen J, Mao CJ, Liu CF. Early-life stress induces prodromal features of Parkinsonian with aging in rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 34448826 DOI: 10.1093/gerona/glab253   
2021 Ma YF, Lin YA, Huang CL, Hsu CC, Wang S, Yeh SR, Tsai YC. Lactiplantibacillus plantarum PS128 Alleviates Exaggerated Cortical Beta Oscillations and Motor Deficits in the 6-Hydroxydopamine Rat Model of Parkinson's Disease. Probiotics and Antimicrobial Proteins. PMID 34449056 DOI: 10.1007/s12602-021-09828-x   
2021 Scheffer DDL, Freitas FC, Aguiar AS, Ward C, Guglielmo LGA, Prediger RD, Cronin SJF, Walz R, Andrews NA, Latini A. Impaired dopamine metabolism is linked to fatigability in mice and fatigue in Parkinson's disease patients. Brain Communications. 3: fcab116. PMID 34423297 DOI: 10.1093/braincomms/fcab116   
2021 Zuo L, Dai C, Yi L, Dong Z. 7,8-dihydroxyflavone ameliorates motor deficits via regulating autophagy in MPTP-induced mouse model of Parkinson's disease. Cell Death Discovery. 7: 254. PMID 34545064 DOI: 10.1038/s41420-021-00643-5   
2021 Malave L, Zuelke DR, Uribe-Cano S, Starikov L, Rebholz H, Friedman E, Qin C, Li Q, Bezard E, Kottmann AH. Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson's disease and L-Dopa induced dyskinesia. Communications Biology. 4: 1071. PMID 34552196 DOI: 10.1038/s42003-021-02567-3   
2021 Zhang C, Zhao M, Wang B, Su Z, Guo B, Qin L, Zhang W, Zheng R. The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of Celastrol in Parkinson's disease. Redox Biology. 47: 102134. PMID 34600334 DOI: 10.1016/j.redox.2021.102134   
2021 Pottenger AE, Bartlett MJ, Sherman SJ, Falk T, Morrison HW. Evaluation of microglia in a rodent model of Parkinson's disease primed with L-DOPA after sub-anesthetic ketamine treatment. Neuroscience Letters. 136251. PMID 34536508 DOI: 10.1016/j.neulet.2021.136251   
2021 Guo YJ, Xiong H, Chen K, Zou JJ, Lei P. Brain regions susceptible to alpha-synuclein spreading. Molecular Psychiatry. PMID 34561613 DOI: 10.1038/s41380-021-01296-7   
2021 Erhardt B, Marcora MS, Frenkel L, Bochicchio PA, Bodin DH, Silva BA, Farías MI, Allo MÁ, Höcht C, Ferrari CC, Pitossi FJ, Leal MC. Plasma membrane calcium ATPase downregulation in dopaminergic neurons alters cellular physiology and motor behaviour in Drosophila melanogaster. The European Journal of Neuroscience. PMID 34312939 DOI: 10.1111/ejn.15401   
2021 Liu Y, Huang Q, Wei Z, Ma S, Woodgett JR, Li M, Li J. GSK-3 mediates nuclear translocation of p62/SQSTM1 in MPTP-induced mouse model of Parkinson's disease. Neuroscience Letters. 136177. PMID 34400288 DOI: 10.1016/j.neulet.2021.136177   
2021 Cai P, Zheng Y, Sun Y, Zhang C, Zhang Q, Liu Q. New Blood-Brain Barrier Models Using Primary Parkinson's Disease Rat Brain Endothelial Cells and Astrocytes for the Development of Central Nervous System Drug Delivery Systems. Acs Chemical Neuroscience. PMID 34623131 DOI: 10.1021/acschemneuro.1c00118   
2021 Maillet A, Météreau E, Tremblay L, Favre E, Klinger H, Lhommée E, Le Bars D, Castrioto A, Prange S, Sgambato V, Broussolle E, Krack P, Thobois S. Serotonergic and Dopaminergic Lesions Underlying Parkinsonian Neuropsychiatric Signs. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 34494685 DOI: 10.1002/mds.28722   
2021 Heurtaux T, Kirchmeyer M, Koncina E, Felten P, Richart L, Uriarte Huarte O, Schohn H, Mittelbronn M. Apomorphine Reduces A53T α-Synuclein-Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway. Cellular and Molecular Neurobiology. PMID 34415465 DOI: 10.1007/s10571-021-01131-1   
2021 García-Pardo J, Novio F, Nador F, Cavaliere I, Suárez-García S, Lope-Piedrafita S, Candiota AP, Romero-Gimenez J, Rodríguez-Galván B, Bové J, Vila M, Lorenzo J, Ruiz-Molina D. Bioinspired Theranostic Coordination Polymer Nanoparticles for Intranasal Dopamine Replacement in Parkinson's Disease. Acs Nano. 15: 8592-8609. PMID 33885286 DOI: 10.1021/acsnano.1c00453   
2021 Nam MH, Park JH, Song HJ, Choi JW, Kim S, Jang BK, Yoon HH, Heo JY, Lee H, An H, Kim HJ, Park SJ, Cho DW, Yang YS, Han SC, et al. KDS2010, a Newly Developed Reversible MAO-B Inhibitor, as an Effective Therapeutic Candidate for Parkinson's Disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 34611843 DOI: 10.1007/s13311-021-01097-4   
2021 Metta V, Batzu L, Leta V, Trivedi D, Powdleska A, Mridula KR, Kukle P, Goyal V, Borgohain R, Chung-Faye G, Chaudhuri KR. Parkinson's Disease: Personalized Pathway of Care for Device-Aided Therapies (DAT) and the Role of Continuous Objective Monitoring (COM) Using Wearable Sensors. Journal of Personalized Medicine. 11. PMID 34357147 DOI: 10.3390/jpm11070680   
2021 Bantle CM, Rocha SM, French CT, Phillips AT, Tran K, Olson KE, Bass TA, Aboellail T, Smeyne RJ, Tjalkens RB. Astrocyte inflammatory signaling mediates α-synuclein aggregation and dopaminergic neuronal loss following viral encephalitis. Experimental Neurology. 346: 113845. PMID 34454938 DOI: 10.1016/j.expneurol.2021.113845   
2021 Li B, Yang S, Ye J, Chu S, Chen N, An Z. Flavin-containing monooxygenase 1 deficiency promotes neuroinflammation in dopaminergic neurons in mice. Neuroscience Letters. 136222. PMID 34500002 DOI: 10.1016/j.neulet.2021.136222   
2021 Shan J, Qu Y, Wang S, Wei Y, Chang L, Ma L, Hashimoto K. Regulation of neurotoxicity in the striatum and colon of MPTP-induced Parkinson's disease mice by gut microbiome. Brain Research Bulletin. PMID 34560239 DOI: 10.1016/j.brainresbull.2021.09.009   
2021 Jiang W, Zou W, Hu M, Tian Q, Xiao F, Li M, Zhang P, Chen YJ, Jiang JM. Hydrogen sulfide attenuates neuronal apoptosis of substantia nigra by reestablishing autophagic flux via promoting leptin signaling in a 6-hydroxydopamine rat model of Parkinson's disease. Clinical and Experimental Pharmacology & Physiology. PMID 34494284 DOI: 10.1111/1440-1681.13587   
2021 Kang B, Li N, Liu S, Qi S, Mu S. Protective Effect of Isopulegol in Alleviating Neuroinflammation in Lipopolysaccharide-Induced BV-2 Cells and in Parkinson Disease Model Induced with MPTP. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society For Environmental Toxicology and Cancer. 40: 75-85. PMID 34587406 DOI: 10.1615/JEnvironPatholToxicolOncol.2021038944   
2021 Burbulla LF, Zheng J, Song P, Jiang W, Johnson ME, Brundin P, Krainc D. Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson's disease models. Jci Insight. 6. PMID 34622801 DOI: 10.1172/jci.insight.148649   
2021 Huang M, Lou D, Charli A, Kong D, Jin H, Zenitsky G, Anantharam V, Kanthasamy A, Wang Z, Kanthasamy AG. Mitochondrial dysfunction-induced H3K27 hyperacetylation perturbs enhancers in Parkinson's disease. Jci Insight. 6. PMID 34494552 DOI: 10.1172/jci.insight.138088   
2021 Sharma A, Müller J, Schuetze K, Rolfes V, Bissinger R, Rosero N, Ahmad A, Franklin BS, Zur B, Fröhlich H, Lang F, Oldenburg J, Pötzsch B, Wüllner U. Comprehensive Profiling of Blood Coagulation and Fibrinolysis Marker Reveals Elevated Plasmin-Antiplasmin Complexes in Parkinson's Disease. Biology. 10. PMID 34439949 DOI: 10.3390/biology10080716   
2021 Prasad EM, Hung SY. Current Therapies in Clinical Trials of Parkinson's Disease: A 2021 Update. Pharmaceuticals (Basel, Switzerland). 14. PMID 34451813 DOI: 10.3390/ph14080717   
2021 Cai HY, Fu XX, Jiang H, Han S. Adjusting vascular permeability, leukocyte infiltration, and microglial cell activation to rescue dopaminergic neurons in rodent models of Parkinson's disease. Npj Parkinson's Disease. 7: 91. PMID 34625569 DOI: 10.1038/s41531-021-00233-3   
2021 Rodriguez-Pallares J, Garcia-Garrote M, Parga JA, Labandeira-Garcia JL. Dose-dependent effect of mesenchymal stromal cells co-grafted with dopaminergic neurons in a Parkinson's disease rat model. Journal of Cellular and Molecular Medicine. PMID 34535974 DOI: 10.1111/jcmm.16900   
2021 Kwon SH, Kim S, Park AY, Lee S, Gadhe CG, Seo BA, Park JS, Jo S, Oh Y, Kweon SH, Ma SX, Kim WR, Kim M, Kim H, Kim JE, et al. A Novel, Selective c-Abl Inhibitor, Compound 5, Prevents Neurodegeneration in Parkinson's Disease. Journal of Medicinal Chemistry. PMID 34583507 DOI: 10.1021/acs.jmedchem.1c01022   
2021 Cattaneo S, Regoni M, Sassone J, Taverna S. Cell-attached and Whole-cell Patch-clamp Recordings of Dopamine Neurons in the Substantia Nigra Pars Compacta of Mouse Brain Slices. Bio-Protocol. 11: e4109. PMID 34458403 DOI: 10.21769/BioProtoc.4109   
2021 Hwu PW, Kiening K, Anselm I, Compton DR, Nakajima T, Opladen T, Pearl PL, Roubertie A, Roujeau T, Muramatsu SI. Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease. Embo Molecular Medicine. 13: e14712. PMID 34423905 DOI: 10.15252/emmm.202114712