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Kazuhisa Sekimizu - Publications

Affiliations: 
Department of Pharmacy Tokyo University, Minato-ku, Tōkyō-to, Japan 
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Year Citation  Score
2022 Miyashita A, Mitsutomi S, Mizushima T, Sekimizu K. Repurposing the PDMA-approved drugs in Japan using an insect model of staphylococcal infection. Fems Microbes. 3: xtac014. PMID 37332511 DOI: 10.1093/femsmc/xtac014  0.621
2022 Hamamoto H, Miyashita A, Kamura K, Horie R, Sekimizu K. Silkworm arylsulfatase in the midgut content is expressed in the silk gland and fed via smearing on the food from the spinneret. Drug Discoveries & Therapeutics. 16: 280-285. PMID 36450504 DOI: 10.5582/ddt.2022.01088  0.632
2022 Miyashita A, Sekimizu K, Kaito C. Surrounding gas composition affects the calling song development in the two-spotted cricket (Gryllus bimaculatus). Drug Discoveries & Therapeutics. PMID 36070890 DOI: 10.5582/ddt.2022.01058  0.591
2022 Li W, Miyashita A, Sekimizu K. Peanut triacylglycerols activate innate immunity both in insects and mammals. Scientific Reports. 12: 7464. PMID 35523841 DOI: 10.1038/s41598-022-11494-0  0.631
2021 Hamamoto H, Panthee S, Paudel A, Ishii K, Yasukawa J, Su J, Miyashita A, Itoh H, Tokumoto K, Inoue M, Sekimizu K. Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus. Nature Communications. 12: 6364. PMID 34737305 DOI: 10.1038/s41467-021-26702-0  0.658
2021 Miyashita A, Hamamoto H, Sekimizu K. Applying the silkworm model for the search of immunosuppressants. Drug Discoveries & Therapeutics. 15: 139-142. PMID 34234062 DOI: 10.5582/ddt.2021.01041  0.653
2021 Nakajima H, Miyashita A, Hamamoto H, Sekimizu K. A novel application of bubble-eye strain of Carassius auratus for ex vivo fish immunological studies. Scientific Reports. 11: 10757. PMID 34031429 DOI: 10.1038/s41598-021-89882-1  0.643
2021 Miyashita A, Sekimizu K. Using silkworms to search for lactic acid bacteria that contribute to infection prevention and improvement of hyperglycemia. Drug Discoveries & Therapeutics. PMID 33746185 DOI: 10.5582/ddt.2021.01020  0.648
2021 Miyashita A, Shimomura K, Nakajima H, Matsumoto Y, Sekimizu K. A digital scheme of human trials for the evaluation of functional foods. Drug Discoveries & Therapeutics. 15: 9-13. PMID 33642540 DOI: 10.5582/ddt.2021.01018  0.6
2020 Kaito C, Yoshikai H, Wakamatsu A, Miyashita A, Matsumoto Y, Fujiyuki T, Kato M, Ogura Y, Hayashi T, Isogai T, Sekimizu K. Non-pathogenic Escherichia coli acquires virulence by mutating a growth-essential LPS transporter. Plos Pathogens. 16: e1008469. PMID 32324807 DOI: 10.1371/Journal.Ppat.1008469  0.691
2020 Paudel A, Hamamoto H, Panthee S, Matsumoto Y, Sekimizu K. Large-scale screening and identification of novel pathogenic Staphylococcus aureus genes using a silkworm infection model. The Journal of Infectious Diseases. PMID 31912866 DOI: 10.1093/Infdis/Jiaa004  0.376
2019 Matsumoto Y, Ishii M, Hasegawa S, Sekimizu K. Enterococcus faecalis YM0831 suppresses sucrose-induced hyperglycemia in a silkworm model and in humans. Communications Biology. 2: 157. PMID 31925042 DOI: 10.1038/s42003-019-0407-5  0.6
2019 Mitsutomi S, Akimitsu N, Sekimizu K, Kaito C. Identification of 2H phosphoesterase superfamily proteins with 2´-CPDase activity. Biochimie. PMID 31422053 DOI: 10.1016/J.Biochi.2019.08.008  0.727
2019 Ishii M, Matsumoto Y, Katada T, Sekimizu K. Additive effects of Kothala himbutu (Salacia reticulata) extract and a lactic acid bacterium (Enterococcus faecalis YM0831) for suppression of sucrose-induced hyperglycemia in an in vivo silkworm evaluation system. Drug Discoveries & Therapeutics. 13: 133-136. PMID 31327788 DOI: 10.5582/Ddt.2019.01025  0.629
2019 Ryuno H, Nigo F, Naguro I, Sekimizu K, Kaito C. Staphylococcus aureus aggregation in the plasma fraction of silkworm hemolymph. Plos One. 14: e0217517. PMID 31145754 DOI: 10.1371/Journal.Pone.0217517  0.306
2019 Matsumoto Y, Ishii M, Hasegawa S, Sekimizu K. YM0831 suppresses sucrose-induced hyperglycemia in a silkworm model and in humans. Communications Biology. 2: 157. PMID 31069266 DOI: 10.1038/s42003-019-0407-5  0.598
2019 Matsumoto Y, Sekimizu K. Silkworm as an experimental animal for research on fungal infections. Microbiology and Immunology. PMID 30666711 DOI: 10.1111/1348-0421.12668  0.315
2019 Paudel A, Panthee S, Hamamoto H, Sekimizu K. GPI0363 inhibits the interaction of RNA polymerase with DNA in Staphylococcus aureus Rsc Advances. 9: 37889-37894. DOI: 10.1039/C9Ra06844A  0.309
2018 Ishii M, Matsumoto Y, Sekimizu K. Bacterial polysaccharides inhibit sucrose-induced hyperglycemia in silkworms. Drug Discoveries & Therapeutics. 12: 185-188. PMID 30146618 DOI: 10.5582/Ddt.2018.01040  0.636
2018 Ishii M, Matsumoto Y, Sekimizu K. Inhibitory effects of alpha-cyclodextrin and its derivative against sucrose-induced hyperglycemia in an in vivo evaluation system. Drug Discoveries & Therapeutics. 12: 122-125. PMID 29998992 DOI: 10.5582/Ddt.2018.01028  0.604
2018 Hamamoto H, Sekimizu K. [Development of Antibiotics Using Silkworm Bacteria and Fungi Infection Model]. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan. 138: 895-899. PMID 29962465 DOI: 10.1248/Yakushi.17-00202-4  0.306
2018 Ishii M, Matsumoto Y, Sekimizu K. Estimation of lactic acid bacterial cell number by DNA quantification. Drug Discoveries & Therapeutics. 12: 88-91. PMID 29760341 DOI: 10.5582/Ddt.2018.01019  0.635
2017 Matsumoto Y, Ishii M, Shimizu K, Kawamoto S, Sekimizu K. [A Silkworm Infection Model to Evaluate Antifungal Drugs for Cryptococcosis]. Medical Mycology Journal. 58: E131-E137. PMID 29187715 DOI: 10.3314/mmj.17.016  0.592
2017 Kochi Y, Matsumoto Y, Sekimizu K, Kaito C. Two-spotted cricket as an animal infection model of human pathogenic fungi. Drug Discoveries & Therapeutics. PMID 29081438 DOI: 10.5582/Ddt.2017.01052  0.316
2017 Urai M, Aizawa T, Imamura K, Hamamoto H, Sekimizu K. Characterization of the chemical structure and innate immune-stimulating activity of an extracellular polysaccharide from Rhizobium sp. strain M2 screened using a silkworm muscle contraction assay. Drug Discoveries & Therapeutics. 11: 238-245. PMID 29021503 DOI: 10.5582/Ddt.2017.01045  0.711
2017 Itoh H, Tokumoto K, Kaji T, Paudel A, Panthee S, Hamamoto H, Sekimizu K, Inoue M. Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic. The Journal of Organic Chemistry. PMID 29019678 DOI: 10.1021/Acs.Joc.7B02318  0.307
2017 Ishii M, Matsumoto Y, Yamada T, Abe S, Sekimizu K. An invertebrate infection model for evaluating anti-fungal agents against dermatophytosis. Scientific Reports. 7: 12289. PMID 28947778 DOI: 10.1038/S41598-017-12523-Z  0.644
2017 Tabuchi F, Matsumoto Y, Ishii M, Tatsuno K, Okazaki M, Sato T, Moriya K, Sekimizu K. D-cycloserine increases the effectiveness of vancomycin against vancomycin-highly resistant Staphylococcus aureus. The Journal of Antibiotics. PMID 28588223 DOI: 10.1038/Ja.2017.56  0.627
2017 Paudel A, Hamamoto H, Panthee S, Kaneko K, Matsunaga S, Kanai M, Suzuki Y, Sekimizu K. A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in Staphylococcus aureus. Frontiers in Microbiology. 8: 712. PMID 28487682 DOI: 10.3389/Fmicb.2017.00712  0.352
2017 Nishida S, Ishii M, Nishiyama Y, Abe S, Ono Y, Sekimizu K. Lactobacillus paraplantarum 11-1 Isolated from Rice Bran Pickles Activated Innate Immunity and Improved Survival in a Silkworm Bacterial Infection Model. Frontiers in Microbiology. 8: 436. PMID 28373863 DOI: 10.3389/Fmicb.2017.00436  0.641
2017 Panthee S, Paudel A, Hamamoto H, Sekimizu K. Advantages of the Silkworm As an Animal Model for Developing Novel Antimicrobial Agents. Frontiers in Microbiology. 8: 373. PMID 28326075 DOI: 10.3389/Fmicb.2017.00373  0.324
2017 Ishii M, Matsumoto Y, Nakamura I, Sekimizu K. Silkworm fungal infection model for identification of virulence genes in pathogenic fungus and screening of novel antifungal drugs. Drug Discoveries & Therapeutics. PMID 28228617 DOI: 10.5582/Ddt.2016.01080  0.634
2017 Ishii M, Matsumoto Y, Nishida S, Sekimizu K. Decreased sugar concentration in vegetable and fruit juices by growth of functional lactic acid bacteria. Drug Discoveries & Therapeutics. PMID 28202883 DOI: 10.5582/Ddt.2016.01079  0.628
2017 Ishii M, Nishida S, Kataoka K, Nishiyama Y, Abe S, Sekimizu K. Lactic acid bacteria of the Leuconostoc genus with high innate immunity-stimulating activity. Drug Discoveries & Therapeutics. PMID 28202882 DOI: 10.5582/Ddt.2016.01078  0.639
2017 Tabuchi F, Matsumoto Y, Ishii M, Tatsuno K, Okazaki M, Sato T, Moriya K, Sekimizu K. Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus. The Journal of Antibiotics. PMID 28196977 DOI: 10.1038/Ja.2017.7  0.628
2016 Yamamoto M, Kashimoto T, Yoshimura Y, Tachibana N, Kuroda S, Miki Y, Kitabayashi S, Tong P, Xiao J, Tanaka K, Hamamoto H, Sekimizu K, Yamamoto K. A silkworm infection model to investigate Vibrio vulnificus virulence genes. Molecular Medicine Reports. PMID 27748924 DOI: 10.3892/Mmr.2016.5782  0.321
2016 Kizaki H, Omae Y, Tabuchi F, Saito Y, Sekimizu K, Kaito C. Cell-Surface Phenol Soluble Modulins Regulate Staphylococcus aureus Colony Spreading. Plos One. 11: e0164523. PMID 27723838 DOI: 10.1371/Journal.Pone.0164523  0.336
2016 Imae K, Saito Y, Kizaki H, Ryuno H, Mao H, Miyashita A, Suzuki Y, Sekimizu K, Kaito C. Novel nucleoside diphosphatase contributes to Staphylococcus aureus virulence. The Journal of Biological Chemistry. PMID 27422825 DOI: 10.1074/Jbc.M116.721845  0.697
2016 Kochi Y, Miyashita A, Tsuchiya K, Mitsuyama M, Sekimizu K, Kaito C. A human pathogenic bacterial infection model using the two-spotted cricket, Gryllus bimaculatus. Fems Microbiology Letters. 363. PMID 27377894 DOI: 10.1093/Femsle/Fnw163  0.681
2016 Matsumoto Y, Ishii M, Sekimizu K. An in vivo invertebrate evaluation system for identifying substances that suppress sucrose-induced postprandial hyperglycemia. Scientific Reports. 6: 26354. PMID 27194587 DOI: 10.1038/Srep26354  0.619
2016 Miyashita A, Kizaki H, Sekimizu K, Kaito C. Body-enlarging effect of royal jelly in a non-holometabolous insect species, Gryllus bimaculatus. Biology Open. 5: 770-6. PMID 27185266 DOI: 10.1242/Bio.019190  0.629
2016 Nishida S, Ono Y, Sekimizu K. Lactic acid bacteria activating innate immunity improve survival in bacterial infection model of silkworm. Drug Discoveries & Therapeutics. 10: 49-56. PMID 26971556 DOI: 10.5582/Ddt.2016.01022  0.324
2016 Matsumoto Y, Yasukawa J, Ishii M, Hayashi Y, Miyazaki S, Sekimizu K. A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus. Scientific Reports. 6: 22894. PMID 26961421 DOI: 10.1038/Srep22894  0.656
2016 Ishii M, Matsumoto Y, Sekimizu K. Usefulness of silkworm as a host animal for understanding pathogenicity of Cryptococcus neoformans. Drug Discoveries & Therapeutics. 10: 9-13. PMID 26902902 DOI: 10.5582/Ddt.2016.01015  0.633
2016 Miyashita A, Kizaki H, Sekimizu K, Kaito C. No Effect of Body Size on the Frequency of Calling and Courtship Song in the Two-Spotted Cricket, Gryllus bimaculatus. Plos One. 11: e0146999. PMID 26785351 DOI: 10.1371/Journal.Pone.0146999  0.618
2015 Ishii M, Matsumoto Y, Sekimizu K. Usefulness of silkworm as a model animal for understanding the molecular mechanisms of fungal pathogenicity. Drug Discoveries & Therapeutics. 9: 234-7. PMID 26370522 DOI: 10.5582/Ddt.2015.01052  0.644
2015 Ishii M, Matsumoto Y, Sekimizu K. Compounds in a particular production lot of tryptic soy broth inhibit Staphylococcus aureus cell growth. Drug Discoveries & Therapeutics. 9: 178-83. PMID 26193939 DOI: 10.5582/Ddt.2015.01030  0.639
2015 Yoshikai H, Kizaki H, Saito Y, Omae Y, Sekimizu K, Kaito C. Multidrug-resistance transporter AbcA secretes Staphylococcus aureus cytolytic toxins. The Journal of Infectious Diseases. PMID 26160745 DOI: 10.1093/Infdis/Jiv376  0.346
2015 Miyashita A, Takahashi S, Ishii K, Sekimizu K, Kaito C. Primed Immune Responses Triggered by Ingested Bacteria Lead to Systemic Infection Tolerance in Silkworms. Plos One. 10: e0130486. PMID 26107254 DOI: 10.1371/Journal.Pone.0130486  0.685
2015 Inagaki Y, Matsumoto Y, Ishii M, Uchino K, Sezutsu H, Sekimizu K. Fluorescence imaging for a noninvasive in vivo toxicity-test using a transgenic silkworm expressing green fluorescent protein. Scientific Reports. 5: 11180. PMID 26061948 DOI: 10.1038/Srep11180  0.614
2015 Matsumoto Y, Ishii M, Hayashi Y, Miyazaki S, Sugita T, Sumiya E, Sekimizu K. Diabetic silkworms for evaluation of therapeutically effective drugs against type II diabetes. Scientific Reports. 5: 10722. PMID 26024298 DOI: 10.1038/Srep10722  0.609
2015 Kyuma T, Kimura S, Hanada Y, Suzuki T, Sekimizu K, Kaito C. Ribosomal RNA methyltransferases contribute to Staphylococcus aureus virulence. The Febs Journal. 282: 2570-84. PMID 25893373 DOI: 10.1111/Febs.13302  0.329
2015 Ishii K, Hamamoto H, Sekimizu K. Studies of host-pathogen interactions and immune-related drug development using the silkworm: interdisciplinary immunology, microbiology, and pharmacology studies. Drug Discoveries & Therapeutics. 9: 238-46. PMID 25865526 DOI: 10.5582/Ddt.2015.01015  0.318
2015 Adachi T, Matsumoto Y, Inagaki Y, Sekimizu K. Niemann-Pick disease type C2 protein induces autophagy and inhibits growth in FM3A breast cancer cells. Drug Discoveries & Therapeutics. 9: 282-8. PMID 25843701 DOI: 10.5582/Ddt.2015.01014  0.775
2015 Miyashita A, Hirai Y, Sekimizu K, Kaito C. Antibiotic-producing bacteria from stag beetle mycangia. Drug Discoveries & Therapeutics. 9: 33-7. PMID 25639488 DOI: 10.5582/Ddt.2015.01000  0.671
2015 Ishii K, Hamamoto H, Sekimizu K. Paralytic peptide: an insect cytokine that mediates innate immunity. Archives of Insect Biochemistry and Physiology. 88: 18-30. PMID 25521626 DOI: 10.1002/Arch.21215  0.304
2015 Hamamoto H, Urai M, Ishii K, Yasukawa J, Paudel A, Murai M, Kaji T, Kuranaga T, Hamase K, Katsu T, Su J, Adachi T, Uchida R, Tomoda H, Yamada M, ... ... Sekimizu K, et al. Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane. Nature Chemical Biology. 11: 127-33. PMID 25485686 DOI: 10.1038/Nchembio.1710  0.771
2014 Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y, Sato H, Yoneda M, Kai C, Yada T, Suzuki Y, Yamada T, Ozawa T, ... ... Sekimizu K, et al. Long Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune Stimuli. Molecular Cell. 54: 1055. PMID 36457191 DOI: 10.1016/j.molcel.2014.06.013  0.764
2014 Uchida R, Hanaki H, Matsui H, Hamamoto H, Sekimizu K, Iwatsuki M, Kim YP, Tomoda H. In vitro and in vivo anti-MRSA activities of nosokomycins. Drug Discoveries & Therapeutics. 8: 249-54. PMID 25639304 DOI: 10.5582/Ddt.2014.01050  0.313
2014 Matsumoto Y, Ishii M, Ishii K, Miyaguchi W, Horie R, Inagaki Y, Hamamoto H, Tatematsu K, Uchino K, Tamura T, Sezutsu H, Sekimizu K. Transgenic silkworms expressing human insulin receptors for evaluation of therapeutically active insulin receptor agonists. Biochemical and Biophysical Research Communications. 455: 159-64. PMID 25449269 DOI: 10.1016/J.Bbrc.2014.10.143  0.6
2014 Ikuo M, Nagano G, Saito Y, Mao H, Sekimizu K, Kaito C. Inhibition of exotoxin production by mobile genetic element SCCmec-encoded psm-mec RNA is conserved in staphylococcal species. Plos One. 9: e100260. PMID 24926994 DOI: 10.1371/Journal.Pone.0100260  0.32
2014 Miyashita A, Kizaki H, Kawasaki K, Sekimizu K, Kaito C. Primed immune responses to gram-negative peptidoglycans confer infection resistance in silkworms. The Journal of Biological Chemistry. 289: 14412-21. PMID 24706746 DOI: 10.1074/Jbc.M113.525139  0.685
2014 Ishii K, Hamamoto H, Sekimizu K. Establishment of a bacterial infection model using the European honeybee, Apis mellifera L. Plos One. 9: e89917. PMID 24587122 DOI: 10.1371/Journal.Pone.0089917  0.337
2014 Ishii K, Adachi T, Hara T, Hamamoto H, Sekimizu K. Identification of a Serratia marcescens virulence factor that promotes hemolymph bleeding in the silkworm, Bombyx mori. Journal of Invertebrate Pathology. 117: 61-7. PMID 24530643 DOI: 10.1016/J.Jip.2014.02.001  0.785
2014 Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y, Sato H, Yoneda M, Kai C, Yada T, Suzuki Y, Yamada T, Ozawa T, ... ... Sekimizu K, et al. Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli. Molecular Cell. 53: 393-406. PMID 24507715 DOI: 10.1016/J.Molcel.2014.01.009  0.771
2014 Numata S, Nagata M, Mao H, Sekimizu K, Kaito C. CvfA protein and polynucleotide phosphorylase act in an opposing manner to regulate Staphylococcus aureus virulence. The Journal of Biological Chemistry. 289: 8420-31. PMID 24492613 DOI: 10.1074/Jbc.M114.554329  0.316
2014 Aoyagi T, Kaito C, Sekimizu K, Omae Y, Saito Y, Mao H, Inomata S, Hatta M, Endo S, Kanamori H, Gu Y, Tokuda K, Yano H, Kitagawa M, Kaku M. Impact of psm-mec in the mobile genetic element on the clinical characteristics and outcome of SCCmec-II methicillin-resistant Staphylococcus aureus bacteraemia in Japan. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. 20: 912-9. PMID 24476401 DOI: 10.1111/1469-0691.12575  0.316
2014 Ishii K, Adachi T, Yasukawa J, Suzuki Y, Hamamoto H, Sekimizu K. Induction of virulence gene expression in Staphylococcus aureus by pulmonary surfactant. Infection and Immunity. 82: 1500-10. PMID 24452679 DOI: 10.1128/Iai.01635-13  0.778
2014 Adachi T, Ishii K, Matsumoto Y, Hayashi Y, Hamamoto H, Sekimizu K. Niemann-Pick disease type C2 protein induces triglyceride accumulation in silkworm and mammalian cell lines. The Biochemical Journal. 459: 137-47. PMID 24438076 DOI: 10.1042/Bj20130876  0.777
2014 Ishii K, Adachi T, Hamamoto H, Sekimizu K. Serratia marcescens suppresses host cellular immunity via the production of an adhesion-inhibitory factor against immunosurveillance cells. The Journal of Biological Chemistry. 289: 5876-88. PMID 24398686 DOI: 10.1074/Jbc.M113.544536  0.79
2014 Tsubota T, Uchino K, Kamimura M, Ishikawa M, Hamamoto H, Sekimizu K, Sezutsu H. Establishment of transgenic silkworms expressing GAL4 specifically in the haemocyte oenocytoid cells Insect Molecular Biology. 23: 165-174. PMID 24237591 DOI: 10.1111/Imb.12071  0.309
2013 Hu Y, Hamamoto H, Sekimizu K. Use of silkworms to evaluate the pathogenicity of bacteria attached to cedar pollen. Drug Discoveries & Therapeutics. 7: 153-7. PMID 24071577 DOI: 10.5582/Ddt.2013.V7.4.153  0.305
2013 Omae Y, Hanada Y, Sekimizu K, Kaito C. Silkworm apolipophorin protein inhibits hemolysin gene expression of Staphylococcus aureus via binding to cell surface lipoteichoic acids. The Journal of Biological Chemistry. 288: 25542-50. PMID 23873929 DOI: 10.1074/Jbc.M113.495051  0.358
2013 Paudel A, Kaneko K, Watanabe A, Matsunaga S, Shigeki M, Kanai M, Motomu K, Hamamoto H, Sekimizu K. Structure-activity relationship study of novel iminothiadiazolo-pyrimidinone antimicrobial agents. The Journal of Antibiotics. 66: 663-7. PMID 23820613 DOI: 10.1038/Ja.2013.69  0.32
2013 Dzoyem JP, Hamamoto H, Ngameni B, Ngadjui BT, Sekimizu K. Antimicrobial action mechanism of flavonoids from Dorstenia species. Drug Discoveries & Therapeutics. 7: 66-72. PMID 23715504 DOI: 10.5582/Ddt.2013.V7.2.66  0.334
2013 Kaito C, Saito Y, Ikuo M, Omae Y, Mao H, Nagano G, Fujiyuki T, Numata S, Han X, Obata K, Hasegawa S, Yamaguchi H, Inokuchi K, Ito T, Hiramatsu K, ... Sekimizu K, et al. Mobile genetic element SCCmec-encoded psm-mec RNA suppresses translation of agrA and attenuates MRSA virulence. Plos Pathogens. 9: e1003269. PMID 23592990 DOI: 10.1371/Journal.Ppat.1003269  0.325
2013 Ishii K, Adachi T, Hamamoto H, Oonishi T, Kamimura M, Imamura K, Sekimizu K. Insect cytokine paralytic peptide activates innate immunity via nitric oxide production in the silkworm Bombyx mori. Developmental and Comparative Immunology. 39: 147-53. PMID 23178406 DOI: 10.1016/J.Dci.2012.10.014  0.782
2012 Nakayama M, Kurokawa K, Nakamura K, Lee BL, Sekimizu K, Kubagawa H, Hiramatsu K, Yagita H, Okumura K, Takai T, Underhill DM, Aderem A, Ogasawara K. Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence. Journal of Immunology (Baltimore, Md. : 1950). 189: 5903-11. PMID 23152562 DOI: 10.4049/Jimmunol.1201940  0.36
2012 Ishii K, Adachi T, Imamura K, Takano S, Usui K, Suzuki K, Hamamoto H, Watanabe T, Sekimizu K. Serratia marcescens induces apoptotic cell death in host immune cells via a lipopolysaccharide- and flagella-dependent mechanism. The Journal of Biological Chemistry. 287: 36582-92. PMID 22859304 DOI: 10.1074/Jbc.M112.399667  0.791
2012 Miyashita A, Iyoda S, Ishii K, Hamamoto H, Sekimizu K, Kaito C. Lipopolysaccharide O-antigen of enterohemorrhagic Escherichia coli O157:H7 is required for killing both insects and mammals. Fems Microbiology Letters. 333: 59-68. PMID 22612664 DOI: 10.1111/J.1574-6968.2012.02599.X  0.672
2012 Shiratsuchi A, Mori T, Sakurai K, Nagaosa K, Sekimizu K, Lee BL, Nakanishi Y. Independent recognition of Staphylococcus aureus by two receptors for phagocytosis in Drosophila. The Journal of Biological Chemistry. 287: 21663-72. PMID 22547074 DOI: 10.1074/Jbc.M111.333807  0.339
2012 Omae Y, Sekimizu K, Kaito C. Inhibition of colony-spreading activity of Staphylococcus aureus by secretion of δ-hemolysin. The Journal of Biological Chemistry. 287: 15570-9. PMID 22411996 DOI: 10.1074/Jbc.M112.357848  0.338
2012 Hamamoto H, Urai M, Paudel A, Horie R, Murakami K, Sekimizu K. [Identification of novel therapeutically effective antibiotics using silkworm infection model]. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan. 132: 79-84. PMID 22214583 DOI: 10.1248/Yakushi.132.79  0.306
2012 Paudel A, Hamamoto H, Kobayashi Y, Yokoshima S, Fukuyama T, Sekimizu K. Identification of novel deoxyribofuranosyl indole antimicrobial agents. The Journal of Antibiotics. 65: 53-7. PMID 22167161 DOI: 10.1038/Ja.2011.110  0.329
2012 Miyazaki S, Matsumoto Y, Sekimizu K, Kaito C. Evaluation of Staphylococcus aureus virulence factors using a silkworm model. Fems Microbiology Letters. 326: 116-24. PMID 22092964 DOI: 10.1111/J.1574-6968.2011.02439.X  0.374
2011 Imamura K, Ishii K, Hamamoto H, Sekimizu K. Hemocytes and humoral factors in silkworm blood are cooperatively involved in sheep erythrocyte aggregation. Drug Discoveries & Therapeutics. 5: 125-9. PMID 22466241 DOI: 10.5582/Ddt.2011.V5.3.125  0.695
2011 Kaito C, Usui K, Kyuma T, Sekimizu K. Isolation of mammalian pathogenic bacteria using silkworms. Drug Discoveries & Therapeutics. 5: 66-70. PMID 22466142 DOI: 10.5582/Ddt.2011.V5.2.66  0.326
2011 Hanada Y, Sekimizu K, Kaito C. Silkworm apolipophorin protein inhibits Staphylococcus aureus virulence. The Journal of Biological Chemistry. 286: 39360-9. PMID 21937431 DOI: 10.1074/Jbc.M111.278416  0.373
2011 Ueno K, Matsumoto Y, Uno J, Sasamoto K, Sekimizu K, Kinjo Y, Chibana H. Intestinal resident yeast Candida glabrata requires Cyb2p-mediated lactate assimilation to adapt in mouse intestine. Plos One. 6: e24759. PMID 21931845 DOI: 10.1371/Journal.Pone.0024759  0.318
2011 Kaito C, Hirano T, Omae Y, Sekimizu K. Digestion of extracellular DNA is required for giant colony formation of Staphylococcus aureus. Microbial Pathogenesis. 51: 142-8. PMID 21539906 DOI: 10.1016/J.Micpath.2011.04.007  0.332
2011 Ueda T, Kaito C, Omae Y, Sekimizu K. Sugar-responsive gene expression and the agr system are required for colony spreading in Staphylococcus aureus. Microbial Pathogenesis. 51: 178-85. PMID 21514374 DOI: 10.1016/J.Micpath.2011.04.003  0.322
2011 Kaito C, Saito Y, Nagano G, Ikuo M, Omae Y, Hanada Y, Han X, Kuwahara-Arai K, Hishinuma T, Baba T, Ito T, Hiramatsu K, Sekimizu K. Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence. Plos Pathogens. 7: e1001267. PMID 21304931 DOI: 10.1371/Journal.Ppat.1001267  0.322
2010 Ishii K, Hamamoto H, Imamura K, Adachi T, Shoji M, Nakayama K, Sekimizu K. Porphyromonas gingivalis peptidoglycans induce excessive activation of the innate immune system in silkworm larvae. The Journal of Biological Chemistry. 285: 33338-47. PMID 20702417 DOI: 10.1074/Jbc.M110.112987  0.784
2010 Tabuchi Y, Shiratsuchi A, Kurokawa K, Gong JH, Sekimizu K, Lee BL, Nakanishi Y. Inhibitory role for D-alanylation of wall teichoic acid in activation of insect Toll pathway by peptidoglycan of Staphylococcus aureus. Journal of Immunology (Baltimore, Md. : 1950). 185: 2424-31. PMID 20639481 DOI: 10.4049/Jimmunol.1000625  0.37
2010 Ishii K, Hamamoto H, Kamimura M, Nakamura Y, Noda H, Imamura K, Mita K, Sekimizu K. Insect cytokine paralytic peptide (PP) induces cellular and humoral immune responses in the silkworm Bombyx mori. The Journal of Biological Chemistry. 285: 28635-42. PMID 20622022 DOI: 10.1074/Jbc.M110.138446  0.746
2010 Ikuo M, Kaito C, Sekimizu K. The cvfC operon of Staphylococcus aureus contributes to virulence via expression of the thyA gene. Microbial Pathogenesis. 49: 1-7. PMID 20347953 DOI: 10.1016/J.Micpath.2010.03.010  0.3
2010 Matsuo M, Kurokawa K, Lee BL, Sekimizu K. Shuttle vectors derived from pN315 for study of essential genes in Staphylococcus aureus. Biological & Pharmaceutical Bulletin. 33: 198-203. PMID 20118540 DOI: 10.1248/Bpb.33.198  0.347
2010 Shiratsuchi A, Shimizu K, Watanabe I, Hashimoto Y, Kurokawa K, Razanajatovo IM, Park KH, Park HK, Lee BL, Sekimizu K, Nakanishi Y. Auxiliary role for D-alanylated wall teichoic acid in Toll-like receptor 2-mediated survival of Staphylococcus aureus in macrophages. Immunology. 129: 268-77. PMID 19845797 DOI: 10.1111/J.1365-2567.2009.03168.X  0.341
2009 Hashimoto Y, Tabuchi Y, Sakurai K, Kutsuna M, Kurokawa K, Awasaki T, Sekimizu K, Nakanishi Y, Shiratsuchi A. Identification of lipoteichoic acid as a ligand for draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes. Journal of Immunology (Baltimore, Md. : 1950). 183: 7451-60. PMID 19890048 DOI: 10.4049/Jimmunol.0901032  0.372
2009 Kurokawa K, Mizumura H, Takaki T, Ishii Y, Ichihashi N, Lee BL, Sekimizu K. Rapid exchange of bound ADP on the Staphylococcus aureus replication initiation protein DnaA. The Journal of Biological Chemistry. 284: 34201-10. PMID 19841480 DOI: 10.1074/Jbc.M109.060681  0.33
2009 Kurokawa K, Hamamoto H, Matsuo M, Nishida S, Yamane N, Lee BL, Murakami K, Maki H, Sekimizu K. Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model. Antimicrobial Agents and Chemotherapy. 53: 4025-7. PMID 19546371 DOI: 10.1128/Aac.00200-09  0.308
2009 Okuyama-Nishida Y, Akiyama N, Sugimori G, Nomura K, Ogawa K, Homma KJ, Sekimizu K, Tsujimoto M, Natori S. Prevention of death in bacterium-infected mice by a synthetic antimicrobial peptide, L5, through activation of host immunity. Antimicrobial Agents and Chemotherapy. 53: 2510-6. PMID 19289519 DOI: 10.1128/Aac.00863-08  0.327
2009 Nagata M, Ito T, Arimitsu N, Koyama H, Sekimizu K. Transcription arrest relief by S-II/TFIIS during gene expression in erythroblast differentiation. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 14: 371-80. PMID 19210546 DOI: 10.1111/J.1365-2443.2008.01277.X  0.301
2009 Takabatake N, Iseki H, Ikehara Y, Kanuka H, Yokoyama N, Sekimizu K, Igarashi I. Isolation and pathogenic characterization of an OB1 variant of Babesia rodhaini which has a glycophorin A-independent pathway to murine red blood cells. Veterinary Parasitology. 159: 97-104. PMID 19084340 DOI: 10.1016/J.Vetpar.2008.10.022  0.308
2009 Oku Y, Kurokawa K, Matsuo M, Yamada S, Lee BL, Sekimizu K. Pleiotropic roles of polyglycerolphosphate synthase of lipoteichoic acid in growth of Staphylococcus aureus cells. Journal of Bacteriology. 191: 141-51. PMID 18952789 DOI: 10.1128/Jb.01221-08  0.329
2008 Kaito C, Omae Y, Matsumoto Y, Nagata M, Yamaguchi H, Aoto T, Ito T, Hiramatsu K, Sekimizu K. A novel gene, fudoh, in the SCCmec region suppresses the colony spreading ability and virulence of Staphylococcus aureus. Plos One. 3: e3921. PMID 19079549 DOI: 10.1371/Journal.Pone.0003921  0.317
2008 Orihara Y, Hamamoto H, Kasuga H, Shimada T, Kawaguchi Y, Sekimizu K. A silkworm baculovirus model for assessing the therapeutic effects of antiviral compounds: characterization and application to the isolation of antivirals from traditional medicines. The Journal of General Virology. 89: 188-194. PMID 18089742 DOI: 10.1099/Vir.0.83208-0  0.328
2008 Kurokawa K, Kaito C, Sekimizu K. Two-component signaling in the virulence of Staphylococcus aureus: a silkworm larvae-pathogenic agent infection model of virulence. Methods in Enzymology. 422: 233-44. PMID 17628142 DOI: 10.1016/S0076-6879(06)22011-1  0.327
2007 Nagata M, Kaito C, Sekimizu K. Phosphodiesterase activity of CvfA is required for virulence in Staphylococcus aureus. The Journal of Biological Chemistry. 283: 2176-84. PMID 17951247 DOI: 10.1074/Jbc.M705309200  0.372
2007 Ishii K, Hamamoto H, Kamimura M, Sekimizu K. Activation of the silkworm cytokine by bacterial and fungal cell wall components via a reactive oxygen species-triggered mechanism. The Journal of Biological Chemistry. 283: 2185-91. PMID 17947232 DOI: 10.1074/Jbc.M705480200  0.336
2007 Li Y, Kurokawa K, Reutimann L, Mizumura H, Matsuo M, Sekimizu K. DnaB and DnaI temperature-sensitive mutants of Staphylococcus aureus: evidence for involvement of DnaB and DnaI in synchrony regulation of chromosome replication. Microbiology (Reading, England). 153: 3370-3379. PMID 17906136 DOI: 10.1099/Mic.0.2007/009001-0  0.327
2007 Ito T, Saso K, Arimitsu N, Sekimizu K. Defective FESTA/EAF2-mediated transcriptional activation in S-II-deficient embryonic stem cells. Biochemical and Biophysical Research Communications. 363: 603-9. PMID 17892859 DOI: 10.1016/J.Bbrc.2007.09.009  0.339
2007 Takabatake N, Okamura M, Yokoyama N, Ikehara Y, Akimitsu N, Arimitsu N, Hamamoto H, Sekimizu K, Suzuki H, Igarashi I. Glycophorin A-knockout mice, which lost sialoglycoproteins from the red blood cell membrane, are resistant to lethal infection of Babesia rodhaini. Veterinary Parasitology. 148: 93-101. PMID 17651898 DOI: 10.1016/J.Vetpar.2007.06.011  0.736
2007 Ishibashi M, Kurokawa K, Nishida S, Ueno K, Matsuo M, Sekimizu K. Isolation of temperature-sensitive mutations in murC of Staphylococcus aureus. Fems Microbiology Letters. 274: 204-9. PMID 17608695 DOI: 10.1111/J.1574-6968.2007.00829.X  0.35
2007 Koyama H, Ito T, Nakanishi T, Sekimizu K. Stimulation of RNA polymerase II transcript cleavage activity contributes to maintain transcriptional fidelity in yeast. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 12: 547-59. PMID 17535246 DOI: 10.1111/J.1365-2443.2007.01072.X  0.329
2007 Ikeda R, Saito F, Matsuo M, Kurokawa K, Sekimizu K, Yamaguchi M, Kawamoto S. Contribution of the mannan backbone of cryptococcal glucuronoxylomannan and a glycolytic enzyme of Staphylococcus aureus to contact-mediated killing of Cryptococcus neoformans. Journal of Bacteriology. 189: 4815-26. PMID 17483230 DOI: 10.1128/Jb.00412-07  0.353
2007 Hattori K, Hirayama M, Suzuki H, Hamamoto H, Sekimizu K, Tamura HO. Cloning and expression of a novel sulfotransferase with unique substrate specificity from Bombyx mori. Bioscience, Biotechnology, and Biochemistry. 71: 1044-51. PMID 17420592 DOI: 10.1271/Bbb.60703  0.305
2007 Matsumoto Y, Kaito C, Morishita D, Kurokawa K, Sekimizu K. Regulation of exoprotein gene expression by the Staphylococcus aureus cvfB gene. Infection and Immunity. 75: 1964-72. PMID 17283102 DOI: 10.1128/Iai.01552-06  0.345
2007 Kaito C, Morishita D, Matsumoto Y, Kurokawa K, Sekimizu K. Novel DNA binding protein SarZ contributes to virulence in Staphylococcus aureus. Molecular Microbiology. 62: 1601-17. PMID 17087772 DOI: 10.1111/J.1365-2958.2006.05480.X  0.368
2006 Kaito C, Sekimizu K. Colony spreading in Staphylococcus aureus. Journal of Bacteriology. 189: 2553-7. PMID 17194792 DOI: 10.1128/Jb.01635-06  0.307
2006 Hossain MS, Hamamoto H, Matsumoto Y, Razanajatovo IM, Larranaga J, Kaito C, Kasuga H, Sekimizu K. Use of silkworm larvae to study pathogenic bacterial toxins. Journal of Biochemistry. 140: 439-44. PMID 16891331 DOI: 10.1093/Jb/Mvj171  0.326
2006 Ito T, Arimitsu N, Takeuchi M, Kawamura N, Nagata M, Saso K, Akimitsu N, Hamamoto H, Natori S, Miyajima A, Sekimizu K. Transcription elongation factor S-II is required for definitive hematopoiesis. Molecular and Cellular Biology. 26: 3194-203. PMID 16581793 DOI: 10.1128/Mcb.26.8.3194-3203.2006  0.732
2006 Murai N, Kurokawa K, Ichihashi N, Matsuo M, Sekimizu K. Isolation of a temperature-sensitive dnaA mutant of Staphylococcus aureus Fems Microbiology Letters. 254: 19-26. PMID 16451174 DOI: 10.1111/J.1574-6968.2005.00012.X  0.329
2006 Nishida S, Kurokawa K, Matsuo M, Sakamoto K, Ueno K, Kita K, Sekimizu K. Identification and characterization of amino acid residues essential for the active site of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from Staphylococcus aureus. The Journal of Biological Chemistry. 281: 1714-24. PMID 16236703 DOI: 10.1074/Jbc.M509277200  0.31
2005 Yamaguchi S, Katagiri S, Sekimizu K, Natori S, Homma KJ. Involvement of EDTP, an egg-derived tyrosine phosphatase, in the early development of Drosophila melanogaster. Journal of Biochemistry. 138: 721-8. PMID 16428301 DOI: 10.1093/Jb/Mvi176  0.304
2005 Aramaki Y, Ogawa K, Toh Y, Ito T, Akimitsu N, Hamamoto H, Sekimizu K, Matsusue K, Kono A, Iguchi H, Takiguchi S. Direct interaction between metastasis-associated protein 1 and endophilin 3. Febs Letters. 579: 3731-6. PMID 15978591 DOI: 10.1016/J.Febslet.2005.05.069  0.724
2005 Kaito C, Kurokawa K, Matsumoto Y, Terao Y, Kawabata S, Hamada S, Sekimizu K. Silkworm pathogenic bacteria infection model for identification of novel virulence genes. Molecular Microbiology. 56: 934-44. PMID 15853881 DOI: 10.1111/J.1365-2958.2005.04596.X  0.368
2005 Rungruang T, Kaneko O, Murakami Y, Tsuboi T, Hamamoto H, Akimitsu N, Sekimizu K, Kinoshita T, Torii M. Erythrocyte surface glycosylphosphatidyl inositol anchored receptor for the malaria parasite. Molecular and Biochemical Parasitology. 140: 13-21. PMID 15694483 DOI: 10.1016/J.Molbiopara.2004.11.017  0.73
2004 Hossain MS, Kurokawa K, Sekimizu K. Induction of fusion-competent myoblast-specific gene expression during myogenic differentiation of Drosophila Schneider cells by DNA double-strand breaks or replication inhibition. Biochimica Et Biophysica Acta. 1743: 176-86. PMID 15777853 DOI: 10.1016/J.Bbamcr.2004.09.033  0.331
2004 Hossain MS, Kurokawa K, Akimitsu N, Sekimizu K. DNA topoisomerase II is required for the G0-to-S phase transition in Drosophila Schneider cells, but not in yeast. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 9: 905-17. PMID 15461662 DOI: 10.1111/J.1365-2443.2004.00783.X  0.73
2004 Ishida T, Akimitsu N, Kashioka T, Hatano M, Kubota T, Ogata Y, Sekimizu K, Katayama T. DiaA, a novel DnaA-binding protein, ensures the timely initiation of Escherichia coli chromosome replication. The Journal of Biological Chemistry. 279: 45546-55. PMID 15326179 DOI: 10.1074/Jbc.M402762200  0.749
2004 Akimitsu N, Kim HS, Hamamoto H, Kamura K, Fukuma N, Arimitsu N, Ono K, Wataya Y, Torii M, Sekimizu K. Duffy antigen is important for the lethal effect of the lethal strain of Plasmodium yoelii 17XL. Parasitology Research. 93: 499-503. PMID 15278442 DOI: 10.1007/S00436-004-1165-X  0.724
2004 Jilma B, Akimitsu N, Fukuma N, Sekimizu K, Jilma-Stohlawetz P. Man, mouse and Duffy genotype-phenotype-specific pharmacokinetics of monocyte chemotactic protein-1. Transfusion Medicine. 14: 251-252. PMID 15180820 DOI: 10.1111/J.0958-7578.2004.00508.X  0.717
2004 Li Y, Kurokawa K, Matsuo M, Fukuhara N, Murakami K, Sekimizu K. Identification of temperature-sensitive dnaD mutants of Staphylococcus aureus that are defective in chromosomal DNA replication. Molecular Genetics and Genomics : Mgg. 271: 447-57. PMID 15042355 DOI: 10.1007/S00438-004-0996-6  0.321
2004 Hamamoto H, Kurokawa K, Kaito C, Kamura K, Manitra Razanajatovo I, Kusuhara H, Santa T, Sekimizu K. Quantitative evaluation of the therapeutic effects of antibiotics using silkworms infected with human pathogenic microorganisms. Antimicrobial Agents and Chemotherapy. 48: 774-9. PMID 14982763 DOI: 10.1128/Aac.48.3.774-779.2004  0.321
2004 Oku Y, Kurokawa K, Ichihashi N, Sekimizu K. Characterization of the Staphylococcus aureus mprF gene, involved in lysinylation of phosphatidylglycerol. Microbiology (Reading, England). 150: 45-51. PMID 14702396 DOI: 10.1099/Mic.0.26706-0  0.365
2003 Kashiwazaki M, Tanaka T, Kanda H, Ebisuno Y, Izawa D, Fukuma N, Akimitsu N, Sekimizu K, Monden M, Miyasaka M. A high endothelial venule-expressing promiscuous chemokine receptor DARC can bind inflammatory, but not lymphoid, chemokines and is dispensable for lymphocyte homing under physiological conditions. International Immunology. 15: 1219-27. PMID 13679391 DOI: 10.1093/Intimm/Dxg121  0.721
2003 Arimitsu N, Akimitsu N, Kotani N, Takasaki S, Kina T, Hamamoto H, Kamura K, Sekimizu K. Glycophorin A requirement for expression of O-linked antigens on the erythrocyte membrane. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 8: 769-77. PMID 12940824 DOI: 10.1046/J.1365-2443.2003.00674.X  0.718
2003 Akimitsu N, Kamura K, Toné S, Sakaguchi A, Kikuchi A, Hamamoto H, Sekimizu K. Induction of apoptosis by depletion of DNA topoisomerase IIalpha in mammalian cells. Biochemical and Biophysical Research Communications. 307: 301-7. PMID 12859955 DOI: 10.1016/S0006-291X(03)01169-0  0.727
2003 Hossain MS, Akimitsu N, Kurokawa K, Sekimizu K. Myogenic differentiation of Drosophila Schneider cells by DNA double-strand break-inducing drugs. Differentiation; Research in Biological Diversity. 71: 271-80. PMID 12823228 DOI: 10.1046/J.1432-0436.2003.7104504.X  0.735
2003 Ichihashi N, Kurokawa K, Matsuo M, Kaito C, Sekimizu K. Inhibitory effects of basic or neutral phospholipid on acidic phospholipid-mediated dissociation of adenine nucleotide bound to DnaA protein, the initiator of chromosomal DNA replication. The Journal of Biological Chemistry. 278: 28778-86. PMID 12767975 DOI: 10.1074/Jbc.M212202200  0.341
2003 Matsuo M, Kurokawa K, Nishida S, Li Y, Takimura H, Kaito C, Fukuhara N, Maki H, Miura K, Murakami K, Sekimizu K. Isolation and mutation site determination of the temperature-sensitive murB mutants of Staphylococcus aureus. Fems Microbiology Letters. 222: 107-13. PMID 12757953 DOI: 10.1016/S0378-1097(03)00260-X  0.341
2003 Akimitsu N, Adachi N, Hirai H, Hossain MS, Hamamoto H, Kobayashi M, Aratani Y, Koyama H, Sekimizu K. Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase IIα Genes to Cells. 8: 393-402. PMID 12653966 DOI: 10.1046/J.1365-2443.2003.00643.X  0.739
2003 Fukuma N, Akimitsu N, Hamamoto H, Kusuhara H, Sugiyama Y, Sekimizu K. A role of the Duffy antigen for the maintenance of plasma chemokine concentrations. Biochemical and Biophysical Research Communications. 303: 137-9. PMID 12646177 DOI: 10.1016/S0006-291X(03)00293-6  0.686
2002 Kaito C, Akimitsu N, Watanabe H, Sekimizu K. Silkworm larvae as an animal model of bacterial infection pathogenic to humans. Microbial Pathogenesis. 32: 183-90. PMID 12079408 DOI: 10.1006/Mpat.2002.0494  0.74
2002 Koyanagi-Katsuta R, Akimitsu N, Hamamoto H, Arimitsu N, Hatano T, Sekimizu K. Embryonic lethality of mutant mice deficient in the p116 gene. Journal of Biochemistry. 131: 833-7. PMID 12038979 DOI: 10.1093/Oxfordjournals.Jbchem.A003172  0.705
2002 Kaito C, Kurokawa K, Hossain MS, Akimitsu N, Sekimizu K. Isolation and characterization of temperature-sensitive mutants of the Staphylococcus aureus dnaC gene. Fems Microbiology Letters. 210: 157-64. PMID 12023093 DOI: 10.1111/J.1574-6968.2002.Tb11175.X  0.749
2002 Hossain MS, Akimitsu N, Takaki T, Hirai H, Sekimizu K. ICRF-193, a catalytic inhibitor of DNA topoisomerase II, inhibits re-entry into the cell division cycle from quiescent state in mammalian cells. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 7: 285-94. PMID 11918672 DOI: 10.1046/J.1365-2443.2002.00521.X  0.725
2002 Aozasa N, Kubo T, Sekimizu K, Natori S. Identification and characterization of a Drosophila homologue of ATBP. Insect Molecular Biology. 11: 31-6. PMID 11841500 DOI: 10.1046/J.0962-1075.2001.00304.X  0.321
2002 Nishida S, Fujimitsu K, Sekimizu K, Ohmura T, Ueda T, Katayama T. A nucleotide switch in the Escherichia coli DnaA protein initiates chromosomal replication: evidnece from a mutant DnaA protein defective in regulatory ATP hydrolysis in vitro and in vivo. The Journal of Biological Chemistry. 277: 14986-95. PMID 11839737 DOI: 10.1074/Jbc.M108303200  0.317
2001 Takeuchi H, Kage E, Sawata M, Kamikouchi A, Ohashi K, Ohara M, Fujiyuki T, Kunieda T, Sekimizu K, Natori S, Kubo T. Identification of a novel gene, Mblk-1, that encodes a putative transcription factor expressed preferentially in the large-type Kenyon cells of the honeybee brain. Insect Molecular Biology. 10: 487-94. PMID 11881813 DOI: 10.1046/J.0962-1075.2001.00288.X  0.326
2001 Inoue R, Kaito C, Tanabe M, Kamura K, Akimitsu N, Sekimizu K. Genetic identification of two distinct DNA polymerases, DnaE and PolC, that are essential for chromosomal DNA replication in Staphylococcus aureus. Molecular Genetics and Genomics : Mgg. 266: 564-71. PMID 11810227 DOI: 10.1007/S004380100564  0.739
2001 Kawakami H, Iwura T, Takata M, Sekimizu K, Hiraga S, Katayama T. Arrest of cell division and nucleoid partition by genetic alterations in the sliding clamp of the replicase and in DnaA. Molecular Genetics and Genomics : Mgg. 266: 167-79. PMID 11683257 DOI: 10.1007/S004380100546  0.331
2001 Aozasa N, Shiraishi H, Kobayashi A, Sekimizu K, Kubo T, Natori S. Interaction between ATBP and DmUbc9 in the expression of the Sarcophaga lectin gene. Biochemical and Biophysical Research Communications. 286: 949-52. PMID 11527391 DOI: 10.1006/Bbrc.2001.5499  0.313
2001 Aozasa N, Shiraishi H, Nakanishi-Matsui M, Kobayashi A, Sekimizu K, Kubo T, Natori S. Activation of the Sarcophaga lectin gene promoter by (A + T)-stretch binding protein. European Journal of Biochemistry / Febs. 268: 2506-11. PMID 11298770 DOI: 10.1046/J.1432-1327.2001.02133.X  0.311
2000 Koyanagi-Katsuta R, Akimitsu N, Arimitsu N, Hatano T, Sekimizu K. Apoptosis of mouse embryonic stem cells induced by single cell suspension. Tissue & Cell. 32: 66-70. PMID 10798319 DOI: 10.1054/Tice.1999.0087  0.729
2000 Takata M, Guo L, Katayama T, Hase M, Seyama Y, Miki T, Sekimizu K. Mutant DnaA proteins defective in duplex opening of oriC, the origin of chromosomal DNA replication in Escherichia coli. Molecular Microbiology. 35: 454-62. PMID 10652106 DOI: 10.1046/J.1365-2958.2000.01722.X  0.332
2000 AKimitsu N, Hamamoto H, Inoue R, Shoji M, Akamine A, Takemori K, Hamasaki N, Sekimizu K. Increase in resistance of methicillin-resistant Staphylococcus aureus to beta-lactams caused by mutations conferring resistance to benzalkonium chloride, a disinfectant widely used in hospitals. Antimicrobial Agents and Chemotherapy. 43: 3042-3. PMID 10651623 DOI: 10.1128/Aac.43.12.3042  0.711
2000 Kurokawa K, Nishida S, Emoto A, Sekimizu K, Katayama T. Replication cycle-coordinated change of the adenine nucleotide-bound forms of DnaA protein in Escherichia coli. The Embo Journal. 18: 6642-52. PMID 10581238 DOI: 10.1093/Emboj/18.23.6642  0.309
2000 Katayama T, Sekimizu K. Inactivation of Escherichia coli DnaA protein by DNA polymerase III and negative regulations for initiation of chromosomal replication. Biochimie. 81: 835-40. PMID 10572296 DOI: 10.1016/S0300-9084(99)00213-8  0.314
1999 Guo L, Katayama T, Seyama Y, Sekimizu K, Miki T. Isolation and characterization of novel cold-sensitive dnaA mutants of Escherichia coli. Fems Microbiology Letters. 176: 357-66. PMID 10427718 DOI: 10.1111/J.1574-6968.1999.Tb13684.X  0.32
1999 Ohba A, Inoue R, Akimitsu N, Mizushima T, Sekimizu K. Identification of proteins whose amounts are altered by mutation in the pgsA gene of Escherichia coli. Biological & Pharmaceutical Bulletin. 21: 1139-41. PMID 9853401 DOI: 10.1248/Bpb.21.1139  0.738
1998 Mizushima T, Takaki T, Kubota T, Tsuchiya T, Miki T, Katayama T, Sekimizu K. Site-directed mutational analysis for the ATP binding of DnaA protein. Functions of two conserved amino acids (Lys-178 and Asp-235) located in the ATP-binding domain of DnaA protein in vitro and in vivo. The Journal of Biological Chemistry. 273: 20847-51. PMID 9694830 DOI: 10.1074/Jbc.273.33.20847  0.322
1998 Katayama T, Kubota T, Kurokawa K, Crooke E, Sekimizu K. The initiator function of DnaA protein is negatively regulated by the sliding clamp of the E. coli Chromosomal replicase Cell. 94: 61-71. PMID 9674428 DOI: 10.1016/S0092-8674(00)81222-2  0.308
1998 Kurokawa K, Mizushima T, Kubota T, Tsuchiya T, Katayama T, Sekimizu K. A stimulation factor for hydrolysis of ATP bound to DnaA protein, the initiator of chromosomal DNA replication in Escherichia coli. Biochemical and Biophysical Research Communications. 243: 90-5. PMID 9473485 DOI: 10.1006/Bbrc.1997.8069  0.308
1998 Katayama T, Takata M, Sekimizu K. CedA is a novel Escherichia coli protein that activates the cell division inhibited by chromosomal DNA over-replication. Molecular Microbiology. 26: 687-97. PMID 9427399 DOI: 10.1046/J.1365-2958.1997.5941967.X  0.368
1997 Katayama T, Akimitsu N, Mizushima T, Miki T, Sekimizu K. Overinitiation of chromosome replication in the Escherichia coli dnaAcos mutant depends on activation of oriC function by the dam gene product. Molecular Microbiology. 25: 661-70. PMID 9379896 DOI: 10.1046/J.1365-2958.1997.5001872.X  0.746
1997 Ogata Y, Inoue R, Mizushima T, Kano Y, Miki T, Sekimizu K. Heat shock-induced excessive relaxation of DNA in Escherichia coli mutants lacking the histone-like protein HU. Biochimica Et Biophysica Acta. 1353: 298-306. PMID 9349725 DOI: 10.1016/S0167-4781(97)00105-X  0.305
1997 Mizushima T, Yokoyama K, Mima S, Tsuchiya T, Sekimizu K. Inhibition of thymidine transport in dnaA mutants of Escherichia coli. The Journal of Biological Chemistry. 272: 21195-200. PMID 9261126 DOI: 10.1074/Jbc.272.34.21195  0.322
1997 Katayama H, Mizushima T, Miki T, Sekimizu K. Molecular cloning and sequence analysis of the dnaA gene of Staphylococcus aureus. Biological & Pharmaceutical Bulletin. 20: 820-2. PMID 9255428 DOI: 10.1248/Bpb.20.820  0.322
1997 Mizushima T, Nishida S, Kurokawa K, Katayama T, Miki T, Sekimizu K. Negative control of DNA replication by hydrolysis of ATP bound to DnaA protein, the initiator of chromosomal DNA replication in Escherichia coli. The Embo Journal. 16: 3724-30. PMID 9218813 DOI: 10.1093/Emboj/16.12.3724  0.345
1997 Ohtsuka Y, Mizushima T, Miki T, Sekimizu K. Transient DNA relaxation in Escherichia coli induced by nalidixic acid. Biological & Pharmaceutical Bulletin. 20: 467-70. PMID 9178922 DOI: 10.1248/Bpb.20.467  0.309
1997 Nishida S, Mizushima T, Miki T, Sekimizu K. Immotile phenotype of an Escherichia coli mutant lacking the histone-like protein HU. Fems Microbiology Letters. 150: 297-301. PMID 9170274 DOI: 10.1111/J.1574-6968.1997.Tb10384.X  0.325
1997 Mizushima T, Koyanagi R, Katayama T, Miki T, Sekimizu K. Decrease in expression of the master operon of flagellin synthesis in a dnaA46 mutant of Escherichia coli. Biological & Pharmaceutical Bulletin. 20: 327-31. PMID 9145203 DOI: 10.1248/Bpb.20.327  0.323
1997 Ohba A, Mizushima T, Katayama T, Sekimizu K. Amounts of proteins altered by mutations in the dnaA gene of Escherichia coli. Febs Letters. 404: 125-8. PMID 9119048 DOI: 10.1016/S0014-5793(97)00108-7  0.328
1997 Mizushima T, Ohtsuka Y, Mori H, Miki T, Sekimizu K. Increase in synthesis and stability of sigma 32 on treatment with inhibitors of DNA gyrase in Escherichia coli. Molecular & General Genetics : Mgg. 253: 297-302. PMID 9003316 DOI: 10.1007/Pl00008596  0.338
1997 Katayama T, Kubota T, Takata M, Akimitsu N, Sekimizu K. Disruption of the hslU gene, which encodes an ATPase subunit of the eukaryotic 26S proteasome homolog in Escherichia coli, suppresses the temperature-sensitive dnaA46 mutation. Biochemical and Biophysical Research Communications. 229: 219-24. PMID 8954109 DOI: 10.1006/Bbrc.1996.1783  0.745
1997 Akimitsu N, Mizushima T, Suzuki E, Miki T, Sekimizu K. Growth phenotypes of Escherichia coli carrying a mutation of acidic phospholipid synthesis. Biological & Pharmaceutical Bulletin. 19: 1275-8. PMID 8913496 DOI: 10.1248/Bpb.19.1275  0.735
1997 Kurokawa K, Mizushima T, Miki T, Sekimizu K. Influence of the linking number of template DNA on sigma 32-dependent transcription initiation in vitro of the Escherichia coli groE gene. Biological & Pharmaceutical Bulletin. 19: 922-31. PMID 8839962 DOI: 10.1248/Bpb.19.922  0.312
1996 Kaneko T, Mizushima T, Ohtsuka Y, Kurokawa K, Kataoka K, Miki T, Sekimizu K. Co-induction of DNA relaxation and synthesis of DnaK and GroEL proteins in Escherichia coli by expression of LetD (CcdB) protein, an inhibitor of DNA gyrase encoded by the F factor. Molecular & General Genetics : Mgg. 250: 593-600. PMID 8676862 DOI: 10.1007/Bf02174447  0.328
1996 Murayama N, Shimizu H, Takiguchi S, Baba Y, Amino H, Horiuchi T, Sekimizu K, Miki T. Evidence for involvement of Escherichia coli genes pmbA, csrA and a previously unrecognized gene tldD, in the control of DNA gyrase by letD (ccdB) of sex factor F. Journal of Molecular Biology. 256: 483-502. PMID 8604133 DOI: 10.1006/Jmbi.1996.0103  0.329
1996 Mizushima T, Koyanagi R, Suzuki E, Tomura A, Kutsukake K, Miki T, Sekimizu K. Control by phosphatidylglycerol of expression of the flhD gene in Escherichia coli. Biochimica Et Biophysica Acta. 1245: 397-401. PMID 8541318 DOI: 10.1016/0304-4165(95)00114-X  0.336
1993 Tomura A, Ishikawa T, Sagara Y, Miki T, Sekimizu K. Requirement of phosphatidylglycerol for flagellation of Escherichia coli. Febs Letters. 329: 287-90. PMID 8396044 DOI: 10.1016/0014-5793(93)80239-Q  0.317
1989 Hirashima S, Horikoshi N, Sekimizu K, Natori S. Production of functional S-II in Bombyx mori cells. Biochemical and Biophysical Research Communications. 160: 1093-9. PMID 2730640 DOI: 10.1016/S0006-291X(89)80115-9  0.31
1987 Hirashima S, Horikoshi M, Nakanishi Y, Hirai H, Sekimizu K, Mizuno D, Natori S. A rapid and simple procedure for purification of S-II, a transcription factor of ribonucleic acid polymerase II. Chemical & Pharmaceutical Bulletin. 35: 877-81. PMID 3594699 DOI: 10.1248/Cpb.35.877  0.547
1987 Sekimizu K, Bramhill D, Kornberg A. ATP activates dnaA protein in initiating replication of plasmids bearing the origin of the E. coli chromosome. Cell. 50: 259-65. PMID 3036372 DOI: 10.1016/0092-8674(87)90221-2  0.421
1986 Baker TA, Sekimizu K, Funnell BE, Kornberg A. Extensive unwinding of the plasmid template during staged enzymatic initiation of DNA replication from the origin of the Escherichia coli chromosome. Cell. 45: 53-64. PMID 3006926 DOI: 10.1016/0092-8674(86)90537-4  0.589
1985 Ohtsuki M, Sekimizu K, Natori S. Accurate transcription initiation in an Ehrlich ascites tumor cell lysate. Journal of Biochemistry. 96: 1267-72. PMID 6097590 DOI: 10.1093/Oxfordjournals.Jbchem.A134945  0.315
1981 Tamura H, Sekimizu K, Obinata M, Natori S. Measurement of a stimulatory protein of RNA polymerase II in various mouse organs by the complement fixation test. Journal of Biochemistry. 88: 1475-80. PMID 7462190 DOI: 10.1093/Oxfordjournals.Jbchem.A133117  0.313
1981 Ueno K, Sekimizu K, Obinata M, Mizuno D, Natori S. Stimulation of messenger ribonucleic acid synthesis in isolated nuclei by a protein that stimulates RNA polymerase II. Biochemistry. 20: 634-40. PMID 6163447 DOI: 10.1021/Bi00506A029  0.553
1979 Sekimizu K, Mizuno D, Natori S. Localization of a factor stimulating RNA polymerase II in the nucleoplasm, revealed by immunofluorescence. Experimental Cell Research. 124: 63-72. PMID 387429 DOI: 10.1016/0014-4827(79)90257-X  0.564
1979 Ueno K, Sekimizu K, Mizuno D, Natori S. Antibody against a stimulatory factor of RNA polymerase II inhibits nuclear RNA synthesis. Nature. 277: 145-6. PMID 366437 DOI: 10.1038/277145A0  0.571
1979 Sekimizu K, Nakanishi Y, Mizuno D, Natori S. Purification and preparation of antibody to RNA polymerase II stimulatory factors from Ehrlich ascites tumor cells. Biochemistry. 18: 1582-8. PMID 106887 DOI: 10.1021/Bi00575A031  0.561
1978 Nakanishi Y, Sekimizu K, Mizuno D, Natori S. Apparent difference in the way of RNA synthesis stimulation by two stimulatory factors of RNA polymerase II. Febs Letters. 93: 357-60. PMID 568564 DOI: 10.1016/0014-5793(78)81139-9  0.531
1977 Sekimizu K, Mizuno D, Natori S. Enhancement of ormation of the initiation complex by factor stimulating RNA polymerase II from Ehrlich ascites tumor cells. Biochimica Et Biophysica Acta. 479: 180-7. PMID 921995 DOI: 10.1016/0005-2787(77)90138-1  0.552
1977 Kuroiwa A, Sekimizu K, Ueno K, Mizuno D, Natori S. Separation of a stimulatory factor of RNA polymerase II from protein kinase activity of Ehrlich ascites tumor cells. Febs Letters. 75: 183-6. PMID 852580 DOI: 10.1016/0014-5793(77)80082-3  0.567
1976 Sekimizu K, Kobayashi N, Mizuno D, Natori S. Purification of a factor from Ehrlich ascites tumor cells specifically stimulating RNA polymerase II. Biochemistry. 15: 5064-70. PMID 990265 DOI: 10.1021/Bi00668A018  0.547
Low-probability matches (unlikely to be authored by this person)
2018 Maruyama T, Baba T, Maemoto Y, Hara-Miyauchi C, Hasegawa-Ogawa M, Okano HJ, Enda Y, Matsumoto K, Arimitsu N, Nakao K, Hamamoto H, Sekimizu K, Ohto-Nakanishi T, Nakanishi H, Tokuyama T, et al. Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis. Cell Death & Disease. 9: 797. PMID 30038238 DOI: 10.1038/S41419-018-0815-3  0.3
1984 Ohtsuki M, Sekimizu K, Agemori M, Shizuta Y, Natori S. Effect of the DNA-binding domain of poly(ADP-ribose)synthetase on accurate transcription initiation in a HeLa cell lysate. Febs Letters. 168: 275-7. PMID 6327367 DOI: 10.1016/0014-5793(84)80261-6  0.299
2016 Nakamura I, Kanasaki R, Yoshikawa K, Furukawa S, Fujie A, Hamamoto H, Sekimizu K. Discovery of a new antifungal agent ASP2397 using a silkworm model of Aspergillus fumigatus infection. The Journal of Antibiotics. PMID 27577982 DOI: 10.1038/Ja.2016.106  0.299
2017 Hamamoto H, Sekimizu K. Development of Novel Antibiotic Lysocin E Identified by Silkworm Infection Model. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan. 137: 389-392. PMID 28381711 DOI: 10.1248/Yakushi.16-00235-4  0.298
2015 Ishii K, Tabuchi F, Matsuo M, Tatsuno K, Sato T, Okazaki M, Hamamoto H, Matsumoto Y, Kaito C, Aoyagi T, Hiramatsu K, Kaku M, Moriya K, Sekimizu K. Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis. Scientific Reports. 5: 17092. PMID 26603341 DOI: 10.1038/Srep17092  0.298
2008 Iijima R, Kunieda T, Yamaguchi S, Kamigaki H, Fujii-Taira I, Sekimizu K, Kubo T, Natori S, Homma KJ. The extracellular adenosine deaminase growth factor, ADGF/CECR1, plays a role in Xenopus embryogenesis via the adenosine/P1 receptor. The Journal of Biological Chemistry. 283: 2255-64. PMID 18032387 DOI: 10.1074/Jbc.M709279200  0.298
2008 Kurokawa K, Nishida S, Ishibashi M, Mizumura H, Ueno K, Yutsudo T, Maki H, Murakami K, Sekimizu K. Staphylococcus aureus MurC participates in L-alanine recognition via histidine 343, a conserved motif in the shallow hydrophobic pocket. Journal of Biochemistry. 143: 417-24. PMID 18084043 DOI: 10.1093/Jb/Mvm237  0.297
2017 Anantaworasakul P, Hamamoto H, Sekimizu K, Okonogi S. In vitro antibacterial activity and in vivo therapeutic effect of Sesbania grandiflora in bacterial infected silkworms. Pharmaceutical Biology. 55: 1256-1262. PMID 28253823 DOI: 10.1080/13880209.2017.1297467  0.297
2004 Nakata A, Ito T, Nagata M, Hori S, Sekimizu K. GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 9: 1125-35. PMID 15507123 DOI: 10.1111/J.1365-2443.2004.00795.X  0.297
2016 Hamamoto H, Sekimizu K. Identification of lysocin E using a silkworm model of bacterial infection. Drug Discoveries & Therapeutics. 10: 24-9. PMID 26911796 DOI: 10.5582/Ddt.2016.01012  0.297
1994 Takata Y, Sagara Y, Kono A, Sekimizu K, Horiuchi T. Gene structure of bovine adrenodoxin reductase. Biological & Pharmaceutical Bulletin. 16: 1200-6. PMID 8130767 DOI: 10.1248/Bpb.16.1200  0.297
2019 Nwibo DD, Panthee S, Hamamoto H, Sekimizu K. Molecular characterization of multi-drug resistant coagulase negative cocci in non-hospital environment. Drug Discoveries & Therapeutics. PMID 31231110 DOI: 10.5582/Ddt.2019.01031  0.296
2019 Matsumoto Y, Takahashi M, Umehara M, Asano M, Maruki-Uchida H, Morita M, Sekimizu K. Suppressive effects of whey protein hydrolysate on sucrose-induced hyperglycemia in silkworms. Drug Discoveries & Therapeutics. PMID 31611487 DOI: 10.5582/Ddt.2019.01069  0.296
2008 Morishita D, Katayama R, Sekimizu K, Tsuruo T, Fujita N. Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Research. 68: 5076-85. PMID 18593906 DOI: 10.1158/0008-5472.Can-08-0634  0.296
2008 Shiokawa K, Aso M, Kondo T, Uchiyama H, Kuroyanagi S, Takai J, Takahashi S, Kajitani M, Kaito C, Sekimizu K, Takayama E, Igarashi K, Hara H. Gene expression in Pre-MBT embryos and activation of maternally-inherited program of apoptosis to be executed at around MBT as a fail-safe mechanism in Xenopus early embryogenesis. Gene Regulation and Systems Biology. 2: 213-31. PMID 19787085 DOI: 10.4137/Grsb.S579  0.295
1985 Sekimizu K, Natori S. Immunological analysis of eukaryotic transcription factor S-II in a HeLa cell lysate. Biochemical and Biophysical Research Communications. 127: 956-61. PMID 3985959 DOI: 10.1016/S0006-291X(85)80037-1  0.295
2004 Okuyama Y, Cho JH, Nakajima Y, Homma K, Sekimizu K, Natori S. Binding between azurocidin and calreticulin: its involvement in the activation of peripheral monocytes. Journal of Biochemistry. 135: 171-7. PMID 15047718 DOI: 10.1093/Jb/Mvh020  0.294
2008 Koyama H, Sumiya E, Nagata M, Ito T, Sekimizu K. Transcriptional repression of the IMD2 gene mediated by the transcriptional co-activator Sub1. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 13: 1113-26. PMID 18823333 DOI: 10.1111/J.1365-2443.2008.01229.X  0.294
2010 Wang DL, Qi FH, Xu HL, Inagaki Y, Orihara Y, Sekimizu K, Kokudo N, Wang FS, Tang W. Apoptosis-inducing activity of compounds screened and characterized from cinobufacini by bioassay-guided isolation. Molecular Medicine Reports. 3: 717-22. PMID 21472305 DOI: 10.3892/Mmr_00000323  0.294
2015 Nwibo DD, Matsumoto Y, Sekimizu K. Identification and methods for prevention of Enterococcus mundtii infection in silkworm larvae, Bombyx mori, reared on artificial diet. Drug Discoveries & Therapeutics. 9: 184-90. PMID 26193940 DOI: 10.5582/Ddt.2015.01036  0.293
1991 Kanai A, Kuzuhara T, Sekimizu K, Natori S. Heterogeneity and tissue-specific expression of eukaryotic transcription factor S-II-related protein mRNA. Journal of Biochemistry. 109: 674-7. PMID 1917889 DOI: 10.1093/Oxfordjournals.Jbchem.A123439  0.291
1983 Sekimizu K, Horikoshi M, Okajima H, Natori S. Identification of subunits of rna polymerase II from ehrlich ascites tumor cells Journal of Biochemistry. 93: 1523-1530. PMID 6684113 DOI: 10.1093/Oxfordjournals.Jbchem.A134290  0.291
2020 Panthee S, Paudel A, Hamamoto H, Uhlemann AC, Sekimizu K. The Role of Amino Acid Substitution in HepT Toward Menaquinone Isoprenoid Chain Length Definition and Lysocin E Sensitivity in . Frontiers in Microbiology. 11: 2076. PMID 32983054 DOI: 10.3389/Fmicb.2020.02076  0.291
2015 Su J, Iehara M, Yasukawa J, Matsumoto Y, Hamamoto H, Sekimizu K. A novel mutation in the vraS gene of Staphylococcus aureus contributes to reduce susceptibility against daptomycin. The Journal of Antibiotics. PMID 25899124 DOI: 10.1038/Ja.2015.42  0.291
1994 Nakamura K, Horiuchi T, Yasukochi T, Sekimizu K, Hara T, Sagara Y. Significant contribution of arginine-112 and its positive charge of Pseudomonas putida cytochrome P-450cam in the electron transport from putidaredoxin. Biochimica Et Biophysica Acta. 1207: 40-8. PMID 8043608 DOI: 10.1016/0167-4838(94)90049-3  0.291
2016 Panthee S, Hamamoto H, Paudel A, Sekimizu K. Lysobacter species: a potential source of novel antibiotics. Archives of Microbiology. PMID 27541998 DOI: 10.1007/S00203-016-1278-5  0.29
1994 Mizushima T, Ohtsuka Y, Miki T, Sekimizu K. Temperature shift-up leads to simultaneous and continuous plasmid DNA relaxation and induction of DnaK and GroEL proteins in anaerobically growing Escherichia coli cells. Fems Microbiology Letters. 121: 333-6. PMID 7926689 DOI: 10.1111/J.1574-6968.1994.Tb07122.X  0.29
2020 Matsumoto Y, Takahashi M, Sekimizu K. Polysaccharides of a fermented food, natto, suppress sucrose-induced hyperglycemia in an in vivo evaluation system and inhibit glucose uptake by human intestinal cells. Drug Discoveries & Therapeutics. 14: 8-13. PMID 32147629 DOI: 10.5582/Ddt.2020.01002  0.29
2009 Kurokawa K, Lee H, Roh KB, Asanuma M, Kim YS, Nakayama H, Shiratsuchi A, Choi Y, Takeuchi O, Kang HJ, Dohmae N, Nakanishi Y, Akira S, Sekimizu K, Lee BL. The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2. The Journal of Biological Chemistry. 284: 8406-11. PMID 19139093 DOI: 10.1074/Jbc.M809618200  0.29
2017 Urai M, Kataoka K, Nishida S, Sekimizu K. Structural analysis of an innate immunostimulant from broccoli, Brassica oleracea var. italica. Drug Discoveries & Therapeutics. PMID 29021502 DOI: 10.5582/Ddt.2017.01044  0.29
1997 Kubota T, Katayama T, Ito Y, Mizushima T, Sekimizu K. Conformational transition of DnaA protein by ATP: structural analysis of DnaA protein, the initiator of Escherichia coli chromosome replication. Biochemical and Biophysical Research Communications. 232: 130-5. PMID 9125116 DOI: 10.1006/Bbrc.1997.6244  0.29
1996 Maki S, Takiguchi S, Horiuchi T, Sekimizu K, Miki T. Partner switching mechanisms in inactivation and rejuvenation of Escherichia coli DNA gyrase by F plasmid proteins LetD (CcdB) and LetA (CcdA). Journal of Molecular Biology. 256: 473-82. PMID 8604132 DOI: 10.1006/Jmbi.1996.0102  0.289
1982 Nakanishi Y, Sekimizu K, Tamura H, Natori S. Purification of a new protein stimulating RNA polymerase II from Ehrlich ascites tumor cells: comparison with proteins purified before. Journal of Biochemistry. 90: 805-14. PMID 7309703 DOI: 10.1093/Oxfordjournals.Jbchem.A133537  0.289
2005 Kawamura N, Kurokawa K, Ito T, Hamamoto H, Koyama H, Kaito C, Sekimizu K. Participation of Rho-dependent transcription termination in oxidative stress sensitivity caused by an rpoB mutation. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 10: 477-87. PMID 15836776 DOI: 10.1111/J.1365-2443.2005.00849.X  0.289
2011 Fukuyama N, Ino C, Suzuki Y, Kobayashi N, Hamamoto H, Sekimizu K, Orihara Y. Antimicrobial sesquiterpenoids from Laurus nobilis L. Natural Product Research. 25: 1295-303. PMID 21678158 DOI: 10.1080/14786419.2010.502532  0.288
2017 Yagi A, Uchida R, Hamamoto H, Sekimizu K, Kimura KI, Tomoda H. Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis. The Journal of Antibiotics. 70: 685-690. PMID 28446822 DOI: 10.1038/Ja.2017.23  0.287
2010 Koyama H, Ueda T, Ito T, Sekimizu K. Novel RNA polymerase II mutation suppresses transcriptional fidelity and oxidative stress sensitivity in rpb9Delta yeast. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 15: 151-9. PMID 20088966 DOI: 10.1111/J.1365-2443.2009.01372.X  0.287
1998 Hase M, Ishikawa Y, Sekimizu K, Tsuchiya T, Mizushima T. Effect of glycerol on the affinity of DnaA protein for ATP in the presence of cardiolipin. Journal of Biochemistry. 123: 680-3. PMID 9538261 DOI: 10.1093/Oxfordjournals.Jbchem.A021991  0.286
2007 Ishino T, Kunieda T, Natori S, Sekimizu K, Kubo T. Identification of novel members of the Xenopus Ca2+ -dependent lectin family and analysis of their gene expression during tail regeneration and development. Journal of Biochemistry. 141: 479-88. PMID 17298960 DOI: 10.1093/Jb/Mvm048  0.286
1985 Hirashima S, Nakanishi Y, Sekimizu K, Natori S. Phosphorylation of S-II is not affected by inhibitors of RNA synthesis. Biochemical and Biophysical Research Communications. 131: 524-31. PMID 2413843 DOI: 10.1016/0006-291X(85)91267-7  0.286
1990 Tamura H, Ikegami Y, Ono K, Sekimizu K, Andoh T. Acidic phospholipids directly inhibit DNA binding of mammalian DNA topoisomerase I. Febs Letters. 261: 151-4. PMID 2155130 DOI: 10.1016/0014-5793(90)80658-6  0.285
1985 Matsumoto N, Sekimizu K, Soma G, Ohmura Y, Andoh T, Nakanishi Y, Obinata M, Natori S. Structural analysis of a developmentally regulated 25-kDa protein gene of Sarcophaga peregrina. Journal of Biochemistry. 97: 1501-8. PMID 2993269 DOI: 10.1093/Oxfordjournals.Jbchem.A135205  0.285
2009 Usui K, Miyazaki S, Kaito C, Sekimizu K. Purification of a soil bacteria exotoxin using silkworm toxicity to measure specific activity Microbial Pathogenesis. 46: 59-62. PMID 19041713 DOI: 10.1016/J.Micpath.2008.10.010  0.285
1994 Yasukochi T, Okada O, Hara T, Sagara Y, Sekimizu K, Horiuchi T. Putative functions of phenylalanine-350 of Pseudomonas putida cytochrome P-450cam. Biochimica Et Biophysica Acta. 1204: 84-90. PMID 8305479 DOI: 10.1016/0167-4838(94)90036-1  0.285
1985 Horikoshi M, Sekimizu K, Natori S. Conformational change of DNA binding subunit of RNA polymerase II on binding to DNA. Biochemical and Biophysical Research Communications. 129: 141-7. PMID 3890852 DOI: 10.1016/0006-291X(85)91414-7  0.285
2018 Paudel A, Panthee S, Urai M, Hamamoto H, Ohwada T, Sekimizu K. Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model. Scientific Reports. 8: 1578. PMID 29371643 DOI: 10.1038/S41598-018-19867-0  0.285
2016 Paudel A, Hamamoto H, Panthee S, Sekimizu K. Menaquinone as a potential target of antibacterial agents. Drug Discoveries & Therapeutics. 10: 123-8. PMID 27431268 DOI: 10.5582/Ddt.2016.01041  0.285
2019 Hamamoto H, Horie R, Sekimizu K. Pharmacokinetics of anti-infectious reagents in silkworms. Scientific Reports. 9: 9451. PMID 31263251 DOI: 10.1038/S41598-019-46013-1  0.285
1998 Shah GH, Kataoka K, Ueno A, Ohtsuka Y, Mizushima T, Sekimizu K. Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity. Biological & Pharmaceutical Bulletin. 20: 1233-4. PMID 9448094 DOI: 10.1248/Bpb.20.1233  0.284
1985 Sekimizu K, Horikoshi M, Natori S. Enhancement of the frequency of initiation by a stimulatory protein of RNA polymerase II. Journal of Biochemistry. 96: 1859-65. PMID 6085080 DOI: 10.1093/Oxfordjournals.Jbchem.A135020  0.284
2007 Nagata M, Arimitsu N, Ito T, Sekimizu K. Antioxidant N-acetyl-L-cysteine inhibits erythropoietin-induced differentiation of erythroid progenitors derived from mouse fetal liver. Cell Biology International. 31: 252-6. PMID 17174578 DOI: 10.1016/J.Cellbi.2006.11.001  0.284
1991 Hirai H, Natori S, Sekimizu K. Inhibitory action of phospholipid-interacting drugs on transcription initiation in a nuclear extract of Ehrlich ascites tumor cells. Biochimica Et Biophysica Acta. 1088: 191-6. PMID 2001395 DOI: 10.1016/0167-4781(91)90054-P  0.283
2003 Ishino T, Shirai M, Kunieda T, Sekimizu K, Natori S, Kubo T. Identification of genes induced in regenerating Xenopus tadpole tails by using the differential display method. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 226: 317-25. PMID 12557209 DOI: 10.1002/Dvdy.10229  0.283
2017 Panthee S, Hamamoto H, Paudel A, Sekimizu K. Genomic analysis of vancomycin-resistant Staphylococcus aureus VRS3b and its comparison with other VRSA isolates. Drug Discoveries & Therapeutics. PMID 28458299 DOI: 10.5582/Ddt.2017.01024  0.282
1989 Takeda S, Sugiyama H, Natori S, Sekimizu K. Nuclear GTP-binding proteins of Swiss 3T3 cells. Febs Letters. 244: 469-72. PMID 2493399 DOI: 10.1016/0014-5793(89)80585-X  0.282
2015 Kyuma T, Kizaki H, Ryuno H, Sekimizu K, Kaito C. 16S rRNA methyltransferase KsgA contributes to oxidative stress resistance and virulence in Staphylococcus aureus. Biochimie. 119: 166-74. PMID 26545800 DOI: 10.1016/J.Biochi.2015.10.027  0.282
2016 Kaji T, Murai M, Itoh H, Yasukawa J, Hamamoto H, Sekimizu K, Inoue M. Total Synthesis and Functional Evaluation of Fourteen Derivatives of Lysocin E: Importance of Cationic, Hydrophobic, and Aromatic Moieties for Antibacterial Activity. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27739191 DOI: 10.1002/Chem.201604022  0.282
1984 Horikoshi M, Tamura H, Sekimizu K, Obinata M, Natori S. Identification of the DNA binding subunit of RNA polymerase II from Ehrlich ascites tumor cells. Journal of Biochemistry. 94: 1761-7. PMID 6686976 DOI: 10.1093/Oxfordjournals.Jbchem.A134527  0.282
2007 Ashibe B, Hirai T, Higashi K, Sekimizu K, Motojima K. Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicing. The Journal of Biological Chemistry. 282: 20763-73. PMID 17510064 DOI: 10.1074/Jbc.M611853200  0.281
2018 Nakajima H, Matsumoto Y, Sekimizu K. Establishment of a gnotobiotic silkworm model. Drug Discoveries & Therapeutics. 12: 291-294. PMID 30464160 DOI: 10.5582/Ddt.2018.01048  0.281
2019 Itoh H, Tokumoto K, Kaji T, Paudel A, Panthee S, Hamamoto H, Sekimizu K, Inoue M. Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E. Nature Communications. 10: 2992. PMID 31278250 DOI: 10.1038/S41467-019-10754-4  0.28
2009 Fujiyuki T, Matsuzaka E, Nakaoka T, Takeuchi H, Wakamoto A, Ohka S, Sekimizu K, Nomoto A, Kubo T. Distribution of Kakugo virus and its effects on the gene expression profile in the brain of the worker honeybee Apis mellifera L. Journal of Virology. 83: 11560-8. PMID 19726502 DOI: 10.1128/Jvi.00519-09  0.28
2011 Dhital S, Hamamoto H, Urai M, Ishii K, Sekimizu K. Purification of innate immunostimulant from green tea using a silkworm muscle contraction assay. Drug Discoveries & Therapeutics. 5: 18-25. PMID 22466092 DOI: 10.5582/Ddt.V5.1.18  0.279
2012 Fujiyuki T, Hamamoto H, Ishii K, Urai M, Kataoka K, Takeda T, Shibata S, Sekimizu K. Evaluation of innate immune stimulating activity of polysaccharides using a silkworm (Bombyx mori) muscle contraction assay. Drug Discoveries and Therapeutics. 6: 88-93. DOI: 10.5582/Ddt.2012.V6.2.88  0.278
2001 Kaito C, Kai M, Higo T, Takayama E, Fukamachi H, Sekimizu K, Shiokawa K. Activation of the maternally preset program of apoptosis by microinjection of 5-aza-2'-deoxycytidine and 5-methyl-2'-deoxycytidine-5'-triphosphate in Xenopus laevis embryos. Development, Growth & Differentiation. 43: 383-90. PMID 11473545 DOI: 10.1046/J.1440-169X.2001.00579.X  0.277
1981 Sekimizu K, Kubo Y, Segawa K, Natori S. Difference in phosphorylation of two factors stimulating RNA polymerase II of Ehrlich ascites tumor cells. Biochemistry. 20: 2286-92. PMID 7236599 DOI: 10.1021/Bi00511A033  0.277
1995 Takeda S, Kita K, Miyazaki H, Natori S, Sekimizu K. Purification of low-molecular-weight GTP-binding proteins structurally related to MTG33, a mitochondrial GTP-binding protein of Ehrlich ascites tumor cells. Journal of Biochemistry. 118: 791-5. PMID 8576094 DOI: 10.1093/Oxfordjournals.Jbchem.A124981  0.277
2015 Murai M, Kaji T, Kuranaga T, Hamamoto H, Sekimizu K, Inoue M. Total synthesis and biological evaluation of the antibiotic lysocin E and its enantiomeric, epimeric, and N-demethylated analogues. Angewandte Chemie (International Ed. in English). 54: 1556-60. PMID 25504563 DOI: 10.1002/Anie.201410270  0.276
2011 Arimitsu N, Kogure T, Baba T, Nakao K, Hamamoto H, Sekimizu K, Yamamoto A, Nakanishi H, Taguchi R, Tagaya M, Tani K. p125/Sec23-interacting protein (Sec23ip) is required for spermiogenesis. Febs Letters. 585: 2171-6. PMID 21640725 DOI: 10.1016/J.Febslet.2011.05.050  0.275
2010 Matsumoto Y, Xu Q, Miyazaki S, Kaito C, Farr CL, Axelrod HL, Chiu HJ, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Sekimizu K, et al. Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module. Structure (London, England : 1993). 18: 537-47. PMID 20399190 DOI: 10.1016/J.Str.2010.02.007  0.274
1989 Lee DI, Hirai H, Natori S, Sekimizu K. Restricted degradation of U6 RNA in a nuclear extract of Ehrlich ascites tumor cells. Journal of Biochemistry. 105: 526-8. PMID 2760013 DOI: 10.1093/Oxfordjournals.Jbchem.A122700  0.274
2017 Maruki-Uchida H, Sai M, Sekimizu K. Evaluation of the innate immune-stimulating activity of amazake using a silkworm muscle contraction assay. Drug Discoveries & Therapeutics. 11: 288-290. PMID 29081455 DOI: 10.5582/Ddt.2017.01051  0.274
2001 Kuroda M, Ohta T, Uchiyama I, Baba T, Yuzawa H, Kobayashi I, Cui L, Oguchi A, Aoki K, Nagai Y, Lian J, Ito T, Kanamori M, Matsumaru H, Maruyama A, ... ... Sekimizu K, et al. Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet. 357: 1225-40. PMID 11418146 DOI: 10.1016/S0140-6736(00)04403-2  0.273
1981 Nakanishi Y, Mitsuhashi Y, Sekimizu K, Yokoi H, Tanaka Y, Horikoshi M, Natori S. Characterization of three proteins stimulating RNA polymerase II. Febs Letters. 130: 69-72. PMID 6169551 DOI: 10.1016/0014-5793(81)80667-9  0.272
1988 Hirai H, Sekimizu K, Horikoshi M, Nakanishi Y, Natori S. Stimulation of transcription from accurate initiation sites by purified S-II. Febs Letters. 238: 119-22. PMID 3169244 DOI: 10.1016/0014-5793(88)80239-4  0.272
2012 Kushida A, Horie R, Hattori K, Hamamoto H, Sekimizu K, Tamura H. Xanthurenic acid is an endogenous substrate for the silkworm cytosolic sulfotransferase, bmST1. Journal of Insect Physiology. 58: 83-8. PMID 22036934 DOI: 10.1016/J.Jinsphys.2011.10.003  0.269
2017 Mitsutomi S, Sekimizu K, Kaito C. Isolation of antibiotic-producing Pseudomonas species with low-temperature cultivation of temperate soil. Drug Discoveries & Therapeutics. 11: 267-275. PMID 29081439 DOI: 10.5582/Ddt.2017.01053  0.269
2011 Matsumoto Y, Sumiya E, Sugita T, Sekimizu K. An invertebrate hyperglycemic model for the identification of anti-diabetic drugs. Plos One. 6: e18292. PMID 21479175 DOI: 10.1371/Journal.Pone.0018292  0.268
1997 NISHIDA S, MIZUSHIMA T, MIKI T, SEKIMIZU K. Immotile phenotype of an mutant lacking the histone-like protein HU Fems Microbiology Letters. 150: 297-301. DOI: 10.1016/S0378-1097(97)00134-1  0.268
1996 Kataoka K, Mizushima T, Ogata Y, Miki T, Sekimizu K. Heat shock-induced DNA relaxation in vitro by DNA gyrase of Escherichia coli in the presence of ATP. The Journal of Biological Chemistry. 271: 24806-10. PMID 8798753 DOI: 10.1074/Jbc.271.40.24806  0.267
1996 Kaneko T, Mizushima T, Ohtsuka Y, Kurokawa K, Kataoka K, Miki T, Sekimizu K. Co-induction of DNA relaxation and synthesis of DnaK and GroEL proteins in Molecular Genetics and Genomics. 250: 593. DOI: 10.1007/S004380050112  0.267
1997 Suzuki E, Mizushima T, Sekimizu K. Alteration of fatty acid composition in a pgsA3 mutant of Escherichia coli. Biological & Pharmaceutical Bulletin. 20: 479-81. PMID 9178924 DOI: 10.1248/Bpb.20.479  0.267
2005 Shiokawa K, Takayama E, Higo T, Kuroyanagi S, Kaito C, Hara H, Kajitani M, Sekimizu K, Tadakuma T, Miura K, Igarashi K, Yaoita Y. Occurrence of pre-MBT synthesis of caspase-8 mRNA and activation of caspase-8 prior to execution of SAMDC (S-adenosylmethionine decarboxylase)-induced, but not p53-induced, apoptosis in Xenopus late blastulae. Biochemical and Biophysical Research Communications. 336: 682-91. PMID 16143307 DOI: 10.1016/J.Bbrc.2005.08.144  0.266
2017 Anantaworasakul P, Hamamoto H, Sekimizu K, Okonogi S. Biological activities and antibacterial biomarker of Sesbania grandiflora bark extract. Drug Discoveries & Therapeutics. 11: 70-77. PMID 28458298 DOI: 10.5582/Ddt.2017.01013  0.263
1991 Hirai H, Takahashi N, Natori S, Sekimizu K. Binding of simian virus 40 large tumor antigen to phospholipid vesicles. Biochimica Et Biophysica Acta. 1090: 305-10. PMID 1954252 DOI: 10.1016/0167-4781(91)90194-Q  0.261
2014 Omae Y, Sekimizu K, Kaito C. Identification of Staphylococcus aureus colony-spreading stimulatory factors from mammalian serum. Plos One. 9: e97670. PMID 24831518 DOI: 10.1371/Journal.Pone.0097670  0.259
1974 Natori S, Sekimizu K, Mizuno D. Organ Specificity and Sensitivity to Alkaline Phosphatase of Factors Stimulating RNA Polymerase II Journal of Biochemistry. 76: 695-702. DOI: 10.1093/Oxfordjournals.Jbchem.A130615  0.259
2016 Inagaki Y, Matsumoto Y, Tang W, Sekimizu K. Dividing phase-dependent cytotoxicity profiling of human embryonic lung fibroblast identifies candidate anticancer reagents. Drug Discoveries & Therapeutics. 10: 195-200. PMID 27594296 DOI: 10.5582/Ddt.2016.01049  0.259
1988 Hirai H, Lee DI, Natori S, Sekimizu K. Uridylation of U6 RNA in a nuclear extract in Ehrlich ascites tumor cells. Journal of Biochemistry. 104: 991-4. PMID 3243771 DOI: 10.1093/Oxfordjournals.Jbchem.A122597  0.258
2011 Matsumoto Y, Miyazaki S, Fukunaga DH, Shimizu K, Kawamoto S, Sekimizu K. Quantitative evaluation of cryptococcal pathogenesis and antifungal drugs using a silkworm infection model with Cryptococcus neoformans. Journal of Applied Microbiology. 112: 138-46. PMID 22040451 DOI: 10.1111/J.1365-2672.2011.05186.X  0.258
2001 Kubota T, Ito Y, Sekimizu K, Tagaya M, Katayama T. DnaA protein Lys-415 is close to the ATP-binding site: ATP-pyridoxal affinity labeling. Biochemical and Biophysical Research Communications. 288: 1141-8. PMID 11700030 DOI: 10.1006/Bbrc.2001.5898  0.258
2016 Nakadai M, Tomida S, Sekimizu K. An Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces. Scientific Reports. 6: 18543. PMID 26730437 DOI: 10.1038/Srep18543  0.256
2016 Inagaki Y, Matsumoto Y, Sekimizu K. Using silkworms to establish alternative animal models for evaluation of drug-induced tissue injury. Drug Discoveries & Therapeutics. 10: 40-3. PMID 26971554 DOI: 10.5582/Ddt.2016.01023  0.256
2008 Koyama H, Sumiya E, Ito T, Sekimizu K. Improved method for the PCR-based gene disruption in Saccharomyces cerevisiae. Fems Yeast Research. 8: 193-4. PMID 18028397 DOI: 10.1111/J.1567-1364.2007.00334.X  0.255
2008 Hamamoto H, Tonoike A, Narushima K, Horie R, Sekimizu K. Silkworm as a model animal to evaluate drug candidate toxicity and metabolism. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp. 149: 334-9. PMID 18804554 DOI: 10.1016/J.Cbpc.2008.08.008  0.255
2012 Inagaki Y, Matsumoto Y, Kataoka K, Matsuhashi N, Sekimizu K. Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph. Bmc Pharmacology & Toxicology. 13: 13. PMID 23137391 DOI: 10.1186/2050-6511-13-13  0.252
1995 Saruta F, Kuramochi T, Nakamura K, Takamiya S, Yu Y, Aoki T, Sekimizu K, Kojima S, Kita K. Stage-specific isoforms of complex II (succinate-ubiquinone oxidoreductase) in mitochondria from the parasitic nematode, Ascaris suum. The Journal of Biological Chemistry. 270: 928-32. PMID 7822332 DOI: 10.1074/Jbc.270.2.928  0.251
1993 Koga H, Sagara Y, Yaoi T, Tsujimura M, Nakamura K, Sekimizu K, Makino R, Shimada H, Ishimura Y, Yura K. Essential role of the Arg112 residue of cytochrome P450cam for electron transfer from reduced putidaredoxin. Febs Letters. 331: 109-13. PMID 8405387 DOI: 10.1016/0014-5793(93)80307-G  0.249
2011 Morishita D, Takami M, Yoshikawa S, Katayama R, Sato S, Kukimoto-Niino M, Umehara T, Shirouzu M, Sekimizu K, Yokoyama S, Fujita N. Cell-permeable carboxyl-terminal p27(Kip1) peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase. The Journal of Biological Chemistry. 286: 2681-8. PMID 21062737 DOI: 10.1074/Jbc.M109.092452  0.246
2019 Ishijima SA, Hiruma M, Sekimizu K, Abe S. Detection of Trichophyton spp. from footwear of patients with tinea pedis. Drug Discoveries & Therapeutics. 13: 207-211. PMID 31534072 DOI: 10.5582/Ddt.2019.01060  0.246
1988 Ohtsuki M, Nakanishi Y, Sekimizu K, Natori S. Difference between supercoiled and linear deoxyribonucleic acids in preinitiation complex formation for accurate transcription in vitro. Chemical & Pharmaceutical Bulletin. 36: 2517-22. PMID 3240472 DOI: 10.1248/Cpb.36.2517  0.245
2016 Matsumoto Y, Sekimizu K. A hyperglycemic silkworm model for evaluating hypoglycemic activity of Rehmanniae Radix, an herbal medicine. Drug Discoveries & Therapeutics. 10: 14-8. PMID 26902904 DOI: 10.5582/Ddt.2016.01016  0.245
2018 Panthee S, Hamamoto H, Ishijima SA, Paudel A, Sekimizu K. Utilization of hybrid assembly approach to determine the genome of an opportunistic pathogenic fungus, Candida albicans TIMM 1768. Genome Biology and Evolution. PMID 30059981 DOI: 10.1093/Gbe/Evy166  0.244
2014 Kaito C, Sekimizu K. 1SAP-04 Role of toxin in Staphylococcus aureus colony spreading(1SAP Supramoleular motility machinery functioning in multi-scale scenes,Symposium,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)) Seibutsu Butsuri. 54: S120. DOI: 10.2142/Biophys.54.S120_3  0.242
2015 Nwibo DD, Hamamoto H, Matsumoto Y, Kaito C, Sekimizu K. Current use of silkworm larvae (Bombyx mori) as an animal model in pharmaco-medical research. Drug Discoveries & Therapeutics. 9: 133-5. PMID 25994065 DOI: 10.5582/Ddt.2015.01026  0.241
2019 Panthee S, Paudel A, Blom J, Hamamoto H, Sekimizu K. Complete Genome Sequence of 0916-4-2 and Its Comparative Genomic Analysis. Frontiers in Microbiology. 10: 1619. PMID 31396169 DOI: 10.3389/Fmicb.2019.01619  0.239
2005 Hamamoto H, Kamura K, Razanajatovo IM, Murakami K, Santa T, Sekimizu K. Effects of molecular mass and hydrophobicity on transport rates through non-specific pathways of the silkworm larva midgut. International Journal of Antimicrobial Agents. 26: 38-42. PMID 15963696 DOI: 10.1016/J.Ijantimicag.2005.03.008  0.237
2015 Mao J, Kuranaga T, Hamamoto H, Sekimizu K, Inoue M. Rational design, synthesis, and biological evaluation of lactam-bridged gramicidin A analogues: discovery of a low-hemolytic antibacterial peptide. Chemmedchem. 10: 540-5. PMID 25510221 DOI: 10.1002/Cmdc.201402473  0.234
2010 Asami Y, Horie R, Hamamoto H, Sekimizu K. Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources. Bmc Pharmacology. 10: 7. PMID 20537191 DOI: 10.1186/1471-2210-10-7  0.23
2017 Panthee S, Paudel A, Hamamoto H, Sekimizu K. Draft Genome Sequence of the Vancomycin-Resistant Clinical Isolate Staphylococcus aureus VRS3b. Genome Announcements. 5. PMID 28572324 DOI: 10.1128/Genomea.00452-17  0.228
2017 Sekimizu K. The Usefulness of Silkworms as a Model Animal for Evaluating the Effectiveness of Medicine and Food. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan. 137: 551-562. PMID 28458287 DOI: 10.1248/Yakushi.16-00249  0.226
2017 Kheawfu K, Pikulkaew S, Hamamoto H, Sekimizu K, Okonogi S. Influence of clove oil and eugenol on muscle contraction of silkworm (Bombyx mori). Drug Discoveries & Therapeutics. PMID 28458297 DOI: 10.5582/Ddt.2017.01012  0.226
2020 Paudel A, Panthee S, Hamamoto H, Sekimizu K. A simple artificial diet available for research of silkworm disease models. Drug Discoveries & Therapeutics. PMID 32830169 DOI: 10.5582/Ddt.2020.03061  0.225
2004 Takeuchi K, Takahashi H, Sugai M, Iwai H, Kohno T, Sekimizu K, Natori S, Shimada I. Channel-forming membrane permeabilization by an antibacterial protein, sapecin: determination of membrane-buried and oligomerization surfaces by NMR. The Journal of Biological Chemistry. 279: 4981-7. PMID 14630928 DOI: 10.1074/Jbc.M307815200  0.224
2017 Inoue M, Fujino H, Nagatomo M, Paudel A, Panthee S, Hamamoto H, Sekimizu K. Unified Total Synthesis of Polyoxin J, L, and Their Fluorinated Analogues Based on Decarbonylative Radical Coupling Reactions. Angewandte Chemie (International Ed. in English). PMID 28727238 DOI: 10.1002/Ange.201706671  0.221
2016 Matsumoto Y, Yasukawa J, Ishii M, Hayashi Y, Miyazaki S, Sekimizu K. A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus Scientific Reports. 6. DOI: 10.1038/srep22894  0.22
2005 Sekimizu K, Larranaga J, Hamamoto H, Sekine M, Furuchi T, Katane M, Homma H, Matsuki N. D-Glutamic acid-induced muscle contraction in the silkworm, Bombyx mori. Journal of Biochemistry. 137: 199-203. PMID 15749834 DOI: 10.1093/Jb/Mvi019  0.22
2017 Panthee S, Hamamoto H, Suzuki Y, Sekimizu K. In silico identification of lysocin biosynthetic gene cluster from Lysobacter sp. RH2180-5. The Journal of Antibiotics. 70: 204-207. PMID 27553855 DOI: 10.1038/Ja.2016.102  0.217
1996 Sagara Y, Matsunaga K, Nakamura K, Aramaki H, Watanabe Y, Hara T, Sekimizu K, Horiuchi T. Purification and characterization of rat adrenodoxin. Biochimie. 77: 719-23. PMID 8789462 DOI: 10.1016/0300-9084(96)88188-0  0.216
2002 Nakanishi T, Sekimizu K. SDT1/SSM1, a multicopy suppressor of S-II null mutant, encodes a novel pyrimidine 5'-nucleotidase. The Journal of Biological Chemistry. 277: 22103-6. PMID 11934891 DOI: 10.1074/JBC.M200573200  0.215
2016 Sekimizu K, Hamamoto H. Using silkworms as a laboratory animal to evaluate medicines and foods. Drug Discoveries & Therapeutics. 10: 1-2. PMID 26971551 DOI: 10.5582/Ddt.2016.01018  0.214
1985 Hayashi H, Nishimura Y, Tsuboi M, Sekimizu K, Nakanishi Y, Natori S. Raman spectrum of a closed-circular DNA. Biopolymers. 24: 1107-11. PMID 4027339 DOI: 10.1002/Bip.360240614  0.214
2015 Mao J, Kuranaga T, Hamamoto H, Sekimizu K, Inoue M. Back Cover: Rational Design, Synthesis, and Biological Evaluation of Lactam-Bridged Gramicidin A Analogues: Discovery of a Low-Hemolytic Antibacterial Peptide (ChemMedChem 3/2015) Chemmedchem. 10: 584-584. DOI: 10.1002/Cmdc.201590006  0.214
2006 Eguchi Y, Ueno S, Kaito C, Sekimizu K, Shiokawa K. Cleavage and survival ofXenopus embryos exposed to 8-T static magnetic Bioelectromagnetics. 27: 612-612. DOI: 10.1002/Bem.20295  0.211
2003 Saso K, Ito T, Natori S, Sekimizu K. Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II. Journal of Biochemistry. 133: 493-500. PMID 12761297 DOI: 10.1093/Jb/Mvg065  0.209
2016 Matsumoto Y, Sekimizu K. Evaluation of anti-diabetic drugs by using silkworm, Bombyx mori. Drug Discoveries & Therapeutics. 10: 19-23. PMID 26961328 DOI: 10.5582/Ddt.2016.01017  0.204
2003 Ubukata T, Shimizu T, Adachi N, Sekimizu K, Nakanishi T. Cleavage, but not read-through, stimulation activity is responsible for three biologic functions of transcription elongation factor S-II. The Journal of Biological Chemistry. 278: 8580-5. PMID 12496271 DOI: 10.1074/jbc.M211384200  0.204
1994 Mizushima T, Tomura A, Shinpuku T, Miki T, Sekimizu K. Loss of flagellation in dnaA mutants of Escherichia coli. Journal of Bacteriology. 176: 5544-6. PMID 8071236 DOI: 10.1128/JB.176.17.5544-5546.1994  0.203
2016 Usui K, Nishida S, Sugita T, Ueki T, Matsumoto Y, Okumura H, Sekimizu K. Acute oral toxicity test of chemical compounds in silkworms. Drug Discoveries & Therapeutics. 10: 57-61. PMID 26971557 DOI: 10.5582/Ddt.2016.01025  0.203
2006 Eguchi Y, Ueno S, Kaito C, Sekimizu K, Shiokawa K. Cleavage and survival of Xenopus embryos exposed to 8 T static magnetic fields in a rotating clinostat. Bioelectromagnetics. 27: 307-13. PMID 16557503 DOI: 10.1002/Bem.20215  0.202
2021 Panthee S, Hamamoto H, Nishiyama Y, Paudel A, Sekimizu K. Novel Pathogenic Mucorales Identified Using the Silkworm Infection Model. Journal of Fungi (Basel, Switzerland). 7. PMID 34829282 DOI: 10.3390/jof7110995  0.202
2018 Sekimizu K, Itoh K. [Platform Development for Drug Discovery Utilizing Silkworm towards "Novel Industrial Revolution"]. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan. 138: 861-862. PMID 29962461 DOI: 10.1248/Yakushi.17-00202-F  0.199
2022 Hamamoto H, Panthee S, Paudel A, Ohgi S, Suzuki Y, Makimura K, Sekimizu K. Transcriptome change of Staphylococcus aureus in infected mouse liver. Communications Biology. 5: 721. PMID 35859002 DOI: 10.1038/s42003-022-03674-5  0.198
1996 Mizushima T, Tanino J, Miki T, Sekimizu K. Decrease in the linking number of plasmid DNA in dnaA mutants of Escherichia coli. Biochemical and Biophysical Research Communications. 218: 137-41. PMID 8573119 DOI: 10.1006/BBRC.1996.0024  0.197
2021 Paudel A, Panthee S, Hamamoto H, Grunert T, Sekimizu K. YjbH regulates virulence genes expression and oxidative stress resistance in . Virulence. 12: 470-480. PMID 33487122 DOI: 10.1080/21505594.2021.1875683  0.191
1996 Mizushima T, Shinpuku T, Katayama H, Kataoka K, Guo L, Miki T, Sekimizu K. Phenotypes of dnaA mutants of Escherichia coli sensitive to phenothiazine derivatives. Molecular & General Genetics : Mgg. 252: 212-5. PMID 8804395 DOI: 10.1007/S004389670024  0.185
2021 Mikami K, Sonobe K, Ishino K, Noda T, Kato M, Hanao M, Hamamoto H, Sekimizu K, Okazaki M. Evaluation of pathogenicity and therapeutic effectiveness of antibiotics using silkworm Nocardia infection model. Drug Discoveries & Therapeutics. 15: 73-77. PMID 33952779 DOI: 10.5582/ddt.2021.01035  0.181
1992 Mizushima T, Natori S, Sekimizu K. Inhibition of Escherichia coli DNA topoisomerase I activity by phospholipids. The Biochemical Journal. 285: 503-6. PMID 1322135 DOI: 10.1042/BJ2850503  0.18
2019 Paudel A, Panthee S, Hamamoto H, Sekimizu K. GPI0363 inhibits the interaction of RNA polymerase with DNA in . Rsc Advances. 9: 37889-37894. PMID 35541796 DOI: 10.1039/c9ra06844a  0.171
1992 Tanji K, Mizushima T, Natori S, Sekimizu K. Induction by psychotropic drugs and local anesthetics of DnaK and GroEL proteins in Escherichia coli. Biochimica Et Biophysica Acta. 1129: 172-6. PMID 1346093 DOI: 10.1016/0167-4781(92)90483-G  0.171
1993 Mizushima T, Natori S, Sekimizu K. Inhibition of DNA synthesis in Meth A cells by chlorpromazine. Biological & Pharmaceutical Bulletin. 16: 953-5. PMID 8287043 DOI: 10.1248/BPB.16.953  0.17
1994 Ogata Y, Miki T, Sekimizu K. A role of heat shock proteins for homologous recombination in Escherichia coli. Biochemical and Biophysical Research Communications. 197: 34-9. PMID 7902713 DOI: 10.1006/BBRC.1993.2437  0.168
1996 Mizushima T, Sasaki S, Ohishi H, Kobayashi M, Katayama T, Miki T, Maeda M, Sekimizu K. Molecular design of inhibitors of in vitro oriC DNA replication based on the potential to block the ATP binding of DnaA protein. The Journal of Biological Chemistry. 271: 25178-83. PMID 8810275 DOI: 10.1074/Jbc.271.41.25178  0.168
1995 Katayama T, Crooke E, Sekimizu K. Characterization of Escherichia coli DnaAcos protein in replication systems reconstituted with highly purified proteins Molecular Microbiology. 18: 813-820. PMID 8825085 DOI: 10.1111/J.1365-2958.1995.18050813.X  0.168
1997 Mizushima T, Matsuo M, Sekimizu K. Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli. Antimicrobial Agents and Chemotherapy. 41: 193-5. PMID 8980780 DOI: 10.1128/Aac.41.1.193  0.167
1996 Mizushima T, Katayama T, Sekimizu K. Effect on DNA topology by DnaA protein, the initiation factor of chromosomal DNA replication in Escherichia coli. Biochemistry. 35: 11512-6. PMID 8784207 DOI: 10.1021/Bi953088F  0.165
1993 Mizushima T, Natori S, Sekimizu K. Relaxation of supercoiled DNA associated with induction of heat shock proteins in Escherichia coli. Molecular & General Genetics : Mgg. 238: 1-5. PMID 8097554 DOI: 10.1007/BF00279523  0.165
1997 Mizushima T, Kataoka K, Ogata Y, Inoue R, Sekimizu K. Increase in negative supercoiling of plasmid DNA in Escherichia coli exposed to cold shock. Molecular Microbiology. 23: 381-6. PMID 9044271 DOI: 10.1046/J.1365-2958.1997.2181582.X  0.163
2021 Hamamoto H, Panthee S, Hashimoto K, Tsuchida T, Sekimizu K. An efficient method to screen for the soil bacteria producing therapeutically effective antibiotics. The Journal of Antibiotics. PMID 34493849 DOI: 10.1038/s41429-021-00476-5  0.163
1995 Shinpuku T, Mizushima T, Guo L, Miki T, Sekimizu K. Phenotypes of dnaA mutants of Escherichia coli sensitive to detergents and organic solvents. Biochemical and Biophysical Research Communications. 212: 84-9. PMID 7612021 DOI: 10.1006/BBRC.1995.1939  0.161
2000 KONDO T, MIMA S, FUKUMA N, SEKIMIZU K, TSUCHIYA T, MIZUSHIMA T. Suppression of temperature-sensitivity of a dnaA46 mutant by excessive DNA supercoiling Biochemical Journal. 348: 375. DOI: 10.1042/0264-6021:3480375  0.158
1997 Ogata Y, Mizushima T, Kataoka K, Kita K, Miki T, Sekimizu K. DnaK heat shock protein of Escherichia coli maintains the negative supercoiling of DNA against thermal stress. The Journal of Biological Chemistry. 271: 29407-14. PMID 8910606 DOI: 10.1074/Jbc.271.46.29407  0.149
1992 Hirai H, Natori S, Sekimizu K. Reversal by phosphatidylglycerol and cardiolipin of inhibition of transcription and replication by histones in vitro. Archives of Biochemistry and Biophysics. 298: 458-63. PMID 1329658 DOI: 10.1016/0003-9861(92)90435-Y  0.148
1993 Hirai H, Takeda S, Natori S, Sekimizu K. Inhibition of SV40 DNA replication in vitro by chlorpromazine. Biological & Pharmaceutical Bulletin. 16: 565-7. PMID 8395935 DOI: 10.1248/BPB.16.565  0.146
2015 Miyashita A, Takahashi S, Ishii K, Sekimizu K, Kaito C. Primed immune responses triggered by ingested bacteria lead to systemic infection tolerance in silkworms Plos One. 10. DOI: 10.1371/journal.pone.0130486  0.145
1997 Matsuo M, Ohtsuka Y, Kataoka K, Mizushima T, Sekimizu K. Transient relaxation of plasmid DNA in Escherichia coli by fluoroquinolones. The Journal of Pharmacy and Pharmacology. 48: 985-7. PMID 8910869 DOI: 10.1111/J.2042-7158.1996.Tb06018.X  0.144
2016 Matsumoto Y, Ishii M, Sekimizu K. An in vivo invertebrate evaluation system for identifying substances that suppress sucrose-induced postprandial hyperglycemia Scientific Reports. 6. DOI: 10.1038/srep26354  0.137
2003 Koyama H, Ito T, Nakanishi T, Kawamura N, Sekimizu K. Transcription elongation factor S-II maintains transcriptional fidelity and confers oxidative stress resistance. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 8: 779-88. PMID 14531857 DOI: 10.1046/J.1365-2443.2003.00677.X  0.137
2014 Kaito C, Sekimizu K. Western Blotting for Staphylococcus aureus AgrA Bio-Protocol. 4. DOI: 10.21769/BIOPROTOC.1071  0.135
1996 Katayama T, Takata M, Sekimizu K. The nucleoid protein H-NS facilitates chromosome DNA replication in Escherichia coli dnaA mutants. Journal of Bacteriology. 178: 5790-2. PMID 8824628 DOI: 10.1128/JB.178.19.5790-5792.1996  0.134
1994 Ogata Y, Mizushima T, Kataoka K, Miki T, Sekimizu K. Identification of DNA topoisomerases involved in immediate and transient DNA relaxation induced by heat shock in Escherichia coli. Molecular & General Genetics : Mgg. 244: 451-5. PMID 8078472 DOI: 10.1007/Bf00583895  0.13
1993 Takeda S, Sagara Y, Kita K, Natori S, Sekimizu K. Purification of a GTP-binding protein localized in mitochondria. Journal of Biochemistry. 114: 684-90. PMID 8113221 DOI: 10.1093/OXFORDJOURNALS.JBCHEM.A124237  0.13
2022 Geberetsadik G, Inaizumi A, Nishiyama A, Yamaguchi T, Hamamoto H, Panthee S, Tamaru A, Hayatsu M, Mizutani Y, Kaboso SA, Hakamata M, Ilinov A, Ozeki Y, Tateishi Y, Sekimizu K, et al. Lysocin E Targeting Menaquinone in the Membrane of Mycobacterium tuberculosis Is a Promising Lead Compound for Antituberculosis Drugs. Antimicrobial Agents and Chemotherapy. e0017122. PMID 35969044 DOI: 10.1128/aac.00171-22  0.13
1996 Mizushima T, Shinpuku T, Katayama H, Kataoka K, Guo L, Miki T, Sekimizu K. Phenotypes ofdnaA mutants ofEscherichia coli sensitive to phenothiazine derivatives Molecular and General Genetics Mgg. 252: 212-215. DOI: 10.1007/BF02173222  0.129
2021 Panthee S, Paudel A, Hamamoto H, Ogasawara AA, Iwasa T, Blom J, Sekimizu K. Complete genome sequence and comparative genomic analysis of Enterococcus faecalis EF-2001, a probiotic bacterium. Genomics. 113: 1534-1542. PMID 33771633 DOI: 10.1016/j.ygeno.2021.03.021  0.117
2022 Hamamoto H, Ogasawara AA, Iwasa M, Sekimizu K. Establishment of a polymerase chain reaction-based method for strain-level management of EF-2001 using species-specific sequences identified by whole genome sequences. Frontiers in Microbiology. 13: 959063. PMID 36033901 DOI: 10.3389/fmicb.2022.959063  0.114
2020 Takada Y, Itoh H, Paudel A, Panthee S, Hamamoto H, Sekimizu K, Inoue M. Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library. Nature Communications. 11: 4935. PMID 33004797 DOI: 10.1038/s41467-020-18711-2  0.112
1993 Sagara Y, Wada A, Takata Y, Waterman MR, Sekimizu K, Horiuchi T. Direct expression of adrenodoxin reductase in Escherichia coli and the functional characterization. Biological & Pharmaceutical Bulletin. 16: 627-30. PMID 8401393 DOI: 10.1248/Bpb.16.627  0.109
1996 Mizushima T, Ishikawa Y, Obana E, Hase M, Kubota T, Katayama T, Kunitake T, Watanabe E, Sekimizu K. Influence of cluster formation of acidic phospholipids on decrease in the affinity for ATP of DnaA protein. The Journal of Biological Chemistry. 271: 3633-8. PMID 8631973 DOI: 10.1074/JBC.271.7.3633  0.108
2023 Nakata Y, Fu J, Itoh H, Panthee S, Hamamoto H, Sekimizu K, Inoue M. Construction of Five Tryptophan Isomers and Application of the Isomers to Solid-Phase Total Syntheses of Lysocin E Derivatives. Chemistry (Weinheim An Der Bergstrasse, Germany). e202301225. PMID 37198137 DOI: 10.1002/chem.202301225  0.108
1996 Saruta F, Hirawake H, Takamiya S, Ma YC, Aoki T, Sekimizu K, Kojima S, Kita K. Cloning of a cDNA encoding the small subunit of cytochrome b558 (cybS) of mitochondrial fumarate reductase (complex II) from adult Ascaris suum. Biochimica Et Biophysica Acta. 1276: 1-5. PMID 8764887 DOI: 10.1016/0005-2728(96)00070-9  0.107
2013 Ishii K, Hamamoto H, Sekimizu K. [Regulation of innate immunity by the insect cytokine paralytic peptide in the silkworm Bombyx mori]. Seikagaku. the Journal of Japanese Biochemical Society. 85: 1091-5. PMID 24505942  0.107
1993 Haq S, Natori S, Sekimizu K. Heat-induced DNA relaxation in vitro by mouse DNA topoisomerase I in the presence of ethidium bromide. Journal of Biochemistry. 113: 620-4. PMID 8393438 DOI: 10.1093/OXFORDJOURNALS.JBCHEM.A124092  0.1
2023 Fu J, Nakata Y, Itoh H, Panthee S, Hamamoto H, Sekimizu K, Inoue M. Molecular Editing Enhances Oxidation Resistance of Mena-quinone-Targeting Antibiotics Lysocin E and WAP-8294A2. Chemistry (Weinheim An Der Bergstrasse, Germany). e202301224. PMID 37328428 DOI: 10.1002/chem.202301224  0.086
2022 Panthee S, Hamamoto H, Paudel A, Kaito C, Suzuki Y, Sekimizu K. Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain of subsp. aureus RN4220. Heliyon. 8: e11376. PMID 36387480 DOI: 10.1016/j.heliyon.2022.e11376  0.083
1997 Saruta F, Hirawake H, Takamiya S, Ma Y, Aoki T, Sekimizu K, Kojima S, Kita K. Cloning of a cDNA encoding the small subunit of cytochrome b558 (cybS) of mitochondrial fumarate reductase (complex II) from adult Ascaris suum Parasitology International. 46: 83. DOI: 10.1016/S1383-5769(97)82561-5  0.073
2014 Hamamoto H, Sekimizu K. [Silkworm as a model animal for drug development]. Seikagaku. the Journal of Japanese Biochemical Society. 86: 578-82. PMID 25509323  0.057
2012 Tomoda H, Sekimizu K. [Recent advance in research of new anti-infectious agents-discovery chemical biology and development-]. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan. 132: 35-6. PMID 22214577 DOI: JST.JSTAGE/yakushi/132.35  0.047
2020 Sekimizu K, Hamamoto H. Use of silkworms as evaluation animals for food and medicine Jsm Mycotoxins. 70: 23-29. DOI: 10.2520/myco.70-1-1  0.047
1996 Mizushima T, Ohtsuka Y, Mori H, Miki T, Sekimizu K. Increase in synthesis and stability of Mgg Molecular & General Genetics. 253: 297. DOI: 10.1007/S004380050325  0.043
2014 Matsumoto Y, Sekimizu K. [Drug discovery for treatment against diabetes by using hyperglycemic silkworms]. Seikagaku. the Journal of Japanese Biochemical Society. 86: 613-9. PMID 25509329  0.028
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