Hirokazu Hirai - Publications

Affiliations: 
Neurophysiology and Neural Repair Gunma University Graduate School of Medicine, Maebashi-shi, Gunma-ken, Japan 

111 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Ninomiya A, Amano I, Kokubo M, Takatsuru Y, Ishii S, Hirai H, Hosoi N, Koibuchi N. Long-term depression-inductive stimulation causes long-term potentiation in mouse Purkinje cells with a mutant thyroid hormone receptor. Proceedings of the National Academy of Sciences of the United States of America. 119: e2210645119. PMID 36322758 DOI: 10.1073/pnas.2210645119  0.343
2022 Shuvaev AN, Belozor OS, Mozhei OI, Shuvaev AN, Fritsler YV, Khilazheva ED, Mosyagina AI, Hirai H, Teschemacher AG, Kasparov S. Indirect Negative Effect of Mutant Ataxin-1 on Short- and Long-Term Synaptic Plasticity in Mouse Models of Spinocerebellar Ataxia Type 1. Cells. 11. PMID 35883691 DOI: 10.3390/cells11142247  0.389
2022 Watanave M, Takahashi N, Hosoi N, Konno A, Yamamoto H, Yasui H, Kawachi M, Horii T, Matsuzaki Y, Hatada I, Hirai H. Protein kinase Cγ in cerebellar Purkinje cells regulates Ca-activated large-conductance K channels and motor coordination. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35145028 DOI: 10.1073/pnas.2113336119  0.307
2021 Nagao S, Hirai H, Kano M, Yuzaki M. Masao Ito-A Visionary Neuroscientist with a Passion for the Cerebellum. Neuroscience. 462: 1-3. PMID 33892899 DOI: 10.1016/j.neuroscience.2021.02.028  0.494
2021 Shuvaev AN, Belozor OS, Mozhei O, Yakovleva DA, Potapenko IV, Shuvaev AN, Smolnikova MV, Salmin VV, Salmina AB, Hirai H, Teschemacher AG, Kasparov S. Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1. Neurobiology of Disease. 105340. PMID 33753288 DOI: 10.1016/j.nbd.2021.105340  0.319
2020 Sato M, Ohta T, Morikawa Y, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H, Seki T. Ataxic phenotype and neurodegeneration are triggered by the impairment of chaperone-mediated autophagy in cerebellar neurons. Neuropathology and Applied Neurobiology. PMID 32722888 DOI: 10.1111/Nan.12649  0.35
2020 Kohara K, Inoue A, Nakano Y, Hirai H, Kobayashi T, Maruyama M, Baba R, Kawashima C. BATTLE: Genetically Engineered Strategies for Split-Tunable Allocation of Multiple Transgenes in the Nervous System. Iscience. 23: 101248. PMID 32629613 DOI: 10.1016/J.Isci.2020.101248  0.318
2020 Sato M, Ueda E, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H, Seki T. Glucocorticoids negatively regulates chaperone mediated autophagy and microautophagy. Biochemical and Biophysical Research Communications. 528: 199-205. PMID 32487317 DOI: 10.1016/J.Bbrc.2020.04.132  0.335
2020 Yasui H, Matsuzaki Y, Konno A, Hirai H. Global Knockdown of Retinoid-related Orphan Receptor α in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia. Neuroscience. PMID 32278059 DOI: 10.1016/J.Neuroscience.2020.04.004  0.43
2020 Chao OY, de Velasco EMF, Pathak SS, Maitra S, Zhang H, Duvick L, Wickman K, Orr HT, Hirai H, Yang YM. Targeting inhibitory cerebellar circuitry to alleviate behavioral deficits in a mouse model for studying idiopathic autism. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32179875 DOI: 10.1038/S41386-020-0656-5  0.348
2020 Ryu Y, Maekawa T, Yoshino D, Sakitani N, Takashima A, Inoue T, Suzurikawa J, Toyohara J, Tago T, Makuuchi M, Fujita N, Sawada K, Murase S, Watanave M, Hirai H, et al. Mechanical Regulation Underlies Effects of Exercise on Serotonin-Induced Signaling in the Prefrontal Cortex Neurons. Iscience. 23: 100874. PMID 32062453 DOI: 10.1016/J.Isci.2020.100874  0.31
2020 Oe Y, Wang X, Patriarchi T, Konno A, Ozawa K, Yahagi K, Hirai H, Tian L, McHugh TJ, Hirase H. Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance. Nature Communications. 11: 471. PMID 31980655 DOI: 10.1038/S41467-020-14378-X  0.355
2020 Ninomiya A, Hosoi N, Kokubo M, Amano I, Haijima A, Miyazaki W, Hirai H, Koibuchi N. SAT-454 A Novel Role of Thyroid Hormone Receptor in Synaptic Plasticity in Cerebellar Purkinje Cells Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.1706  0.415
2019 Hosoi N, Shibasaki K, Hosono M, Konno A, Shinoda Y, Kiyonari H, Inoue K, Muramatsu SI, Ishizaki Y, Hirai H, Furuichi T, Sadakata T. Deletion of class II ARFs in mice causes tremor by the Nav1.6 loss in cerebellar Purkinje cell axon initial segments. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31201232 DOI: 10.1523/Jneurosci.2002-18.2019  0.379
2019 Cendelin J, Buffo A, Hirai H, Magrassi L, Mitoma H, Sherrard R, Vozeh F, Manto M. Task Force Paper On Cerebellar Transplantation: Are We Ready to Treat Cerebellar Disorders with Cell Therapy? Cerebellum (London, England). PMID 30607797 DOI: 10.1007/S12311-018-0999-1  0.326
2019 Watanave M, Hoshino C, Konno A, Fukuzaki Y, Matsuzaki Y, Ishitani T, Hirai H. Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology. Neurobiology of Disease. 121: 263-273. PMID 30343032 DOI: 10.1016/J.Nbd.2018.10.014  0.755
2018 Watanave M, Matsuzaki Y, Nakajima Y, Ozawa A, Yamada M, Hirai H. Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning. Frontiers in Cellular Neuroscience. 12: 490. PMID 30618637 DOI: 10.3389/Fncel.2018.00490  0.422
2018 Shinohara Y, Konno A, Nitta K, Matsuzaki Y, Yasui H, Suwa J, Hiromura K, Hirai H. Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System. Molecular Neurobiology. PMID 30291583 DOI: 10.1007/S12035-018-1366-4  0.308
2018 Seki T, Sato M, Kibe Y, Ohta T, Oshima M, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H. Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240. Neurobiology of Disease. 120: 34-50. PMID 30184469 DOI: 10.1016/J.Nbd.2018.08.022  0.435
2018 Hirai H, Kano M. Type 1 metabotropic glutamate receptor and its signaling molecules as therapeutic targets for the treatment of cerebellar disorders. Current Opinion in Pharmacology. 38: 51-58. PMID 29525719 DOI: 10.1016/J.Coph.2018.02.002  0.401
2018 Ogawa Y, Kakumoto K, Yoshida T, Kuwako KI, Miyazaki T, Yamaguchi J, Konno A, Hata J, Uchiyama Y, Hirai H, Watanabe M, Darnell RB, Okano H, Okano HJ. Elavl3 is essential for the maintenance of Purkinje neuron axons. Scientific Reports. 8: 2722. PMID 29426875 DOI: 10.1038/S41598-018-21130-5  0.344
2018 Matsuzaki Y, Konno A, Mochizuki R, Shinohara Y, Nitta K, Okada Y, Hirai H. Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain. Neuroscience Letters. 665: 182-188. PMID 29175632 DOI: 10.1016/J.Neulet.2017.11.049  0.316
2018 Hirai H. Protein Kinase C in the Cerebellum: Its Significance and Remaining Conundrums. Cerebellum (London, England). 17: 23-27. PMID 29134360 DOI: 10.1007/S12311-017-0898-X  0.418
2017 Takahashi N, Shuvaev AN, Konno A, Matsuzaki Y, Watanave M, Hirai H. Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells. Journal of Neurochemistry. 143: 660-670. PMID 29049849 DOI: 10.1111/Jnc.14239  0.383
2017 Nitta K, Matsuzaki Y, Konno A, Hirai H. Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates. Molecular Therapy. Methods & Clinical Development. 6: 159-170. PMID 28828391 DOI: 10.1016/J.Omtm.2017.07.006  0.339
2017 Shinohara Y, Ohtani T, Konno A, Hirai H. Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo. Cerebellum (London, England). PMID 28508170 DOI: 10.1007/S12311-017-0866-5  0.305
2016 Gonçalves N, Simões AT, Prediger RS, Hirai H, Cunha RA, Pereira de Almeida L. Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia. Annals of Neurology. PMID 28032667 DOI: 10.1002/Ana.24867  0.43
2016 Huda F, Fan Y, Suzuki M, Konno A, Matsuzaki Y, Takahashi N, Chan JK, Hirai H. Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice. Plos One. 11: e0164202. PMID 27802273 DOI: 10.1371/Journal.Pone.0164202  0.406
2016 Arsenault J, Gholizadeh S, Niibori Y, Pacey LK, Halder SK, Koxhioni E, Konno A, Hirai H, Hampson DR. FMRP Expression Levels in Mouse CNS Neurons Determine Behavioral Phenotype. Human Gene Therapy. PMID 27604541 DOI: 10.1089/Hum.2016.090  0.408
2016 Shinohara Y, Konno A, Takahashi N, Matsuzaki Y, Kishi S, Hirai H. Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains. Plos One. 11: e0162023. PMID 27571575 DOI: 10.1371/Journal.Pone.0162023  0.319
2016 Shuvaev AN, Hosoi N, Sato Y, Yanagihara D, Hirai H. Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice. The Journal of Physiology. PMID 27440721 DOI: 10.1113/Jp272950  0.445
2016 Sawada Y, Konno A, Nagaoka J, Hirai H. Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia. Scientific Reports. 6: 27758. PMID 27291422 DOI: 10.1038/Srep27758  0.352
2016 Yanai T, Kurosawa A, Nikaido Y, Nakajima N, Saito T, Osada H, Konno A, Hirai H, Takeda S. Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. PMID 27184081 DOI: 10.1111/Gtc.12378  0.315
2016 Suto N, Mieda T, Iizuka A, Nakamura K, Hirai H. Morphological and Functional Attenuation of Degeneration of Peripheral Neurons by Mesenchymal Stem Cell-Conditioned Medium in Spinocerebellar Ataxia Type 1-Knock-in Mice. Cns Neuroscience & Therapeutics. PMID 27140210 DOI: 10.1111/Cns.12560  0.388
2016 Monai H, Ohkura M, Tanaka M, Oe Y, Konno A, Hirai H, Mikoshiba K, Itohara S, Nakai J, Iwai Y, Hirase H. Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain. Nature Communications. 7: 11100. PMID 27000523 DOI: 10.1016/J.Clinph.2016.10.413  0.357
2016 Matsuzaki Y, Konno A, Mukai R, Honda F, Hirato M, Yoshimoto Y, Hirai H. Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors. Molecular Neurobiology. PMID 26884266 DOI: 10.1007/S12035-016-9777-6  0.342
2016 Conceição M, Mendonça L, Nóbrega C, Gomes C, Costa P, Hirai H, Moreira JN, Lima MC, Manjunath N, Pereira de Almeida L. Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype. Biomaterials. 82: 124-37. PMID 26757259 DOI: 10.1016/J.Biomaterials.2015.12.021  0.316
2015 Mieda T, Suto N, Iizuka A, Matsuura S, Iizuka H, Takagishi K, Nakamura K, Hirai H. Mesenchymal stem cells attenuate peripheral neuronal degeneration in spinocerebellar ataxia type 1 knockin mice. Journal of Neuroscience Research. PMID 26707550 DOI: 10.1002/Jnr.23698  0.343
2015 Ageta-Ishihara N, Yamazaki M, Konno K, Nakayama H, Abe M, Hashimoto K, Nishioka T, Kaibuchi K, Hattori S, Miyakawa T, Tanaka K, Huda F, Hirai H, Hashimoto K, Watanabe M, et al. A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance. Nature Communications. 6: 10090. PMID 26657011 DOI: 10.1038/Ncomms10090  0.395
2015 Nóbrega C, Carmo-Silva S, Albuquerque D, Vasconcelos-Ferreira A, Vijayakumar UG, Mendonça L, Hirai H, Pereira de Almeida L. Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease. Brain : a Journal of Neurology. PMID 26490332 DOI: 10.1093/Brain/Awv298  0.332
2015 Duarte-Neves J, Gonçalves N, Cunha-Santos J, Simões AT, den Dunnen WF, Hirai H, Kügler S, Cavadas C, Pereira de Almeida L. Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease. Human Molecular Genetics. 24: 5451-63. PMID 26220979 DOI: 10.1093/Hmg/Ddv271  0.362
2015 Iizuka A, Matsuzaki Y, Konno A, Hirai H. Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous RORα. Brain Structure & Function. PMID 26122696 DOI: 10.1007/S00429-015-1077-9  0.445
2015 Iizuka A, Nakamura K, Hirai H. Long-term oral administration of the NMDA receptor antagonist memantine extends life span in spinocerebellar ataxia type 1 knock-in mice. Neuroscience Letters. 592: 37-41. PMID 25725171 DOI: 10.1016/J.Neulet.2015.02.055  0.442
2015 Kusakari S, Saitow F, Ago Y, Shibasaki K, Sato-Hashimoto M, Matsuzaki Y, Kotani T, Murata Y, Hirai H, Matsuda T, Suzuki H, Matozaki T, Ohnishi H. Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice. Molecular and Cellular Biology. 35: 1557-72. PMID 25713104 DOI: 10.1128/Mcb.01339-14  0.401
2015 Mendonça LS, Nóbrega C, Hirai H, Kaspar BK, Pereira de Almeida L. Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice. Brain : a Journal of Neurology. 138: 320-35. PMID 25527827 DOI: 10.1093/Brain/Awu352  0.385
2015 Uesaka N, Uchigashima M, Mikuni T, Hirai H, Watanabe M, Kano M. Retrograde signaling for climbing fiber synapse elimination. Cerebellum (London, England). 14: 4-7. PMID 25338972 DOI: 10.1007/S12311-014-0615-Y  0.382
2015 Nakamura K, Mieda T, Suto N, Matsuura S, Hirai H. Mesenchymal stem cells as a potential therapeutic tool for spinocerebellar ataxia. Cerebellum (London, England). 14: 165-70. PMID 25280585 DOI: 10.1007/S12311-014-0604-1  0.339
2015 Takahashi H, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, Shuvaev AN, Sugimoto T, Seki T, Hamada D, Irie K, Hirai H, Sakai N, Saito N. Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein. Human Molecular Genetics. 24: 525-39. PMID 25217572 DOI: 10.1093/Hmg/Ddu472  0.304
2015 Suto N, Nakamura K, Hirai H. Exercise Differentially Affects Cerebellar Cytotoxic Microglia in Spinocerebellar Ataxia Model Mice The Kitakanto Medical Journal. 65: 123-124. DOI: 10.2974/Kmj.65.123  0.307
2015 Huda F, Fan Y, Konno A, Matsuzaki Y, Takahashi N, Chan J, Hirai H. 598. Fusion of Mesenchymal Stem Cells Exclusively with “Degenerating” Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice Molecular Therapy. 23: S237. DOI: 10.1016/S1525-0016(16)34207-1  0.41
2014 Huda F, Konno A, Matsuzaki Y, Goenawan H, Miyake K, Shimada T, Hirai H. Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model. Molecular Therapy. Methods & Clinical Development. 1: 14032. PMID 26015973 DOI: 10.1038/Mtm.2014.32  0.394
2014 Yoshihara S, Takahashi H, Nishimura N, Kinoshita M, Asahina R, Kitsuki M, Tatsumi K, Furukawa-Hibi Y, Hirai H, Nagai T, Yamada K, Tsuboi A. Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons. Cell Reports. 8: 843-57. PMID 25088421 DOI: 10.1016/J.Celrep.2014.06.056  0.301
2014 Saida H, Matsuzaki Y, Takayama K, Iizuka A, Konno A, Yanagi S, Hirai H. One-year follow-up of transgene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice. Gene Therapy. 21: 820-7. PMID 24989813 DOI: 10.1038/Gt.2014.60  0.4
2014 Uesaka N, Uchigashima M, Mikuni T, Nakazawa T, Nakao H, Hirai H, Aiba A, Watanabe M, Kano M. Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain. Science (New York, N.Y.). 344: 1020-3. PMID 24831527 DOI: 10.1126/Science.1252514  0.382
2014 Okonogi N, Nakamura K, Suzuki Y, Suto N, Suzue K, Kaminuma T, Nakano T, Hirai H. Cranial irradiation induces bone marrow-derived microglia in adult mouse brain tissue. Journal of Radiation Research. 55: 713-9. PMID 24706998 DOI: 10.1093/Jrr/Rru015  0.347
2014 Matsuzaki Y, Oue M, Hirai H. Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter. Journal of Neuroscience Methods. 223: 133-43. PMID 24361760 DOI: 10.1016/J.Jneumeth.2013.12.004  0.374
2014 Matsuura S, Shuvaev AN, Iizuka A, Nakamura K, Hirai H. Mesenchymal stem cells ameliorate cerebellar pathology in a mouse model of spinocerebellar ataxia type 1. Cerebellum (London, England). 13: 323-30. PMID 24242763 DOI: 10.1007/S12311-013-0536-1  0.398
2014 Irie T, Matsuzaki Y, Sekino Y, Hirai H. Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells. The Journal of Physiology. 592: 229-47. PMID 24218544 DOI: 10.1113/Jphysiol.2013.264309  0.602
2014 Konno A, Shuvaev AN, Miyake N, Miyake K, Iizuka A, Matsuura S, Huda F, Nakamura K, Yanagi S, Shimada T, Hirai H. Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar Purkinje cells. Cerebellum (London, England). 13: 29-41. PMID 23955261 DOI: 10.1007/S12311-013-0516-5  0.499
2013 Miki T, Hirai H, Takahashi T. Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+ channel subtypes mediating neurotransmitter release. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 18755-63. PMID 24285882 DOI: 10.1523/Jneurosci.3161-13.2013  0.347
2013 Nascimento-Ferreira I, Nóbrega C, Vasconcelos-Ferreira A, Onofre I, Albuquerque D, Aveleira C, Hirai H, Déglon N, Pereira de Almeida L. Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease. Brain : a Journal of Neurology. 136: 2173-88. PMID 23801739 DOI: 10.1093/Brain/Awt144  0.39
2013 Mikuni T, Uesaka N, Okuno H, Hirai H, Deisseroth K, Bito H, Kano M. Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum. Neuron. 78: 1024-35. PMID 23791196 DOI: 10.1016/J.Neuron.2013.04.036  0.368
2013 Yamaura H, Hirai H, Yanagihara D. Postural dysfunction in a transgenic mouse model of spinocerebellar ataxia type 3. Neuroscience. 243: 126-35. PMID 23567815 DOI: 10.1016/J.Neuroscience.2013.03.044  0.347
2013 Nóbrega C, Nascimento-Ferreira I, Onofre I, Albuquerque D, Hirai H, Déglon N, de Almeida LP. Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice. Plos One. 8: e52396. PMID 23349684 DOI: 10.1371/Journal.Pone.0052396  0.414
2013 Takechi Y, Mieda T, Iizuka A, Toya S, Suto N, Takagishi K, Nakazato Y, Nakamura K, Hirai H. Impairment of spinal motor neurons in spinocerebellar ataxia type 1-knock-in mice. Neuroscience Letters. 535: 67-72. PMID 23328439 DOI: 10.1016/J.Neulet.2012.12.057  0.389
2013 Suto N, Nakamura K, Hirai H. Exercise differentially affects cerebellar cytotoxic microglia in spinocerebellar ataxia model mice Kitakanto Medical Journal. 63: 209-215. DOI: 10.2974/Kmj.63.209  0.307
2012 Oue M, Handa H, Matsuzaki Y, Suzue K, Murakami H, Hirai H. The murine stem cell virus promoter drives correlated transgene expression in the leukocytes and cerebellar Purkinje cells of transgenic mice. Plos One. 7: e51015. PMID 23226450 DOI: 10.1371/Journal.Pone.0051015  0.384
2012 Goenawan H, Hirai H. Modulation of lentiviral vector tropism in cerebellar Purkinje cells in vivo by a lysosomal cysteine protease cathepsin K. Journal of Neurovirology. 18: 521-31. PMID 23070819 DOI: 10.1007/S13365-012-0134-X  0.367
2012 Uesaka N, Mikuni T, Hashimoto K, Hirai H, Sakimura K, Kano M. Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11657-70. PMID 22915109 DOI: 10.1523/Jneurosci.1097-12.2012  0.401
2012 Yoshihara S, Takahashi H, Nishimura N, Naritsuka H, Shirao T, Hirai H, Yoshihara Y, Mori K, Stern PL, Tsuboi A. 5T4 glycoprotein regulates the sensory input-dependent development of a specific subtype of newborn interneurons in the mouse olfactory bulb. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 2217-26. PMID 22323733 DOI: 10.1523/Jneurosci.5907-11.2012  0.315
2012 Jin D, Muramatsu S, Shimizu N, Yokoyama S, Hirai H, Yamada K, Liu HX, Higashida C, Hashii M, Higashida A, Asano M, Ohkuma S, Higashida H. Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice. Neurochemistry International. 61: 907-12. PMID 22265874 DOI: 10.1016/J.Neuint.2011.12.021  0.354
2012 Hirai H. Basic research on cerebellar gene therapy using lentiviral vectors. Cerebellum (London, England). 11: 443-5. PMID 22120847 DOI: 10.1007/S12311-011-0330-X  0.35
2011 Shuvaev AN, Horiuchi H, Seki T, Goenawan H, Irie T, Iizuka A, Sakai N, Hirai H. Mutant PKCγ in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14324-34. PMID 21976518 DOI: 10.1523/Jneurosci.5530-10.2011  0.62
2011 Mitsumura K, Hosoi N, Furuya N, Hirai H. Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice. The Journal of Physiology. 589: 3191-209. PMID 21558162 DOI: 10.1113/Jphysiol.2011.207563  0.459
2011 Hirai H, Anton S, Seki T, Sakai N. Disruption of climbing fiber synapse elimination and LTD expression in cerebellar Purkinje cells by mutant γPKC found in spinocerebellar ataxia type 14 Neuroscience Research. 71: e57. DOI: 10.1016/J.Neures.2011.07.241  0.387
2011 Shuvaev AN, Horiuchi H, Seki T, Hanna G, Irie T, Iizuka A, Sakai N, Hirai H. Mutant γPKC found in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo Neuroscience Research. 71. DOI: 10.1016/J.Neures.2011.07.1272  0.563
2011 Hosoi N, Mitsumura K, Hirai H. Impairment of mGluR signaling at cerebellar parallel fiber–Purkinje cell synapses in staggerer mutant mice Neuroscience Research. 71: e246. DOI: 10.1016/J.Neures.2011.07.1075  0.429
2010 Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, ... ... Hirai H, et al. The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature. 465: 497-501. PMID 20463662 DOI: 10.1038/Nature09023  0.407
2010 Sawada Y, Kajiwara G, Iizuka A, Takayama K, Shuvaev AN, Koyama C, Hirai H. High transgene expression by lentiviral vectors causes maldevelopment of Purkinje cells in vivo. Cerebellum (London, England). 9: 291-302. PMID 20178014 DOI: 10.1007/S12311-010-0161-1  0.405
2009 Oue M, Mitsumura K, Torashima T, Koyama C, Yamaguchi H, Furuya N, Hirai H. Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells. Brain Research. 1255: 9-17. PMID 19103174 DOI: 10.1016/J.Brainres.2008.12.014  0.441
2009 Iizuka A, Torashima T, Mitsumura K, Koyama C, Iino M, Hirai H. Lentiviral vector-mediated rescue of motor behavior in hereditary ataxic mice Neuroscience Research. 65: S96. DOI: 10.1016/J.Neures.2009.09.406  0.335
2009 Sawada Y, Kajiwara G, Torashima T, Takayama K, Horiuchi H, Iizuka A, Mitsumura K, Hirai H. Influence of lentiviral vector infection on the development of cerebellar Purkinje cells in vivo Neuroscience Research. 65: S89-S90. DOI: 10.1016/J.Neures.2009.09.366  0.319
2009 Hirai H, Torashima T, Iizuka A. Progress of the δ2 glutamate receptor research from the viewpoint of functional domains Neuroscience Research. 65: S9. DOI: 10.1016/J.Neures.2009.09.1517  0.303
2009 Shuvaev A, Horiuchi H, Iizuka A, Irie T, Iino M, Seki T, Sakai N, Hirai H. A PKCγ mutation in spinocerebellar ataxia type 14 impairs PKC functions in a dominant-negative manner in cerebellar Purkinje cells in vivo Neuroscience Research. 65: S247. DOI: 10.1016/J.Neures.2009.09.1401  0.578
2008 Sato T, Torashima T, Sugihara K, Hirai H, Asano M, Yoshioka K. The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling. Molecular and Cellular Neurosciences. 39: 569-78. PMID 18804538 DOI: 10.1016/J.Mcn.2008.08.003  0.364
2008 Takayama K, Torashima T, Horiuchi H, Hirai H. Purkinje-cell-preferential transduction by lentiviral vectors with the murine stem cell virus promoter. Neuroscience Letters. 443: 7-11. PMID 18675313 DOI: 10.1016/J.Neulet.2008.07.058  0.364
2008 Han L, Suda M, Tsuzuki K, Wang R, Ohe Y, Hirai H, Watanabe T, Takeuchi T, Hosaka M. A large form of secretogranin III functions as a sorting receptor for chromogranin A aggregates in PC12 cells. Molecular Endocrinology (Baltimore, Md.). 22: 1935-49. PMID 18483175 DOI: 10.1210/Me.2008-0006  0.334
2008 Hirai H. Progress in transduction of cerebellar Purkinje cells in vivo using viral vectors. Cerebellum (London, England). 7: 273-8. PMID 18418690 DOI: 10.1007/S12311-008-0012-5  0.378
2008 Torashima T, Koyama C, Iizuka A, Mitsumura K, Takayama K, Yanagi S, Oue M, Yamaguchi H, Hirai H. Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia. Embo Reports. 9: 393-9. PMID 18344973 DOI: 10.1038/Embor.2008.31  0.428
2007 Nakamura K, Hirai H, Torashima T, Miyazaki T, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Tsukamoto K, Nishimura H, Ono M, Watanabe M, Hirose S. CD3 and immunoglobulin G Fc receptor regulate cerebellar functions. Molecular and Cellular Biology. 27: 5128-34. PMID 17502348 DOI: 10.1128/Mcb.01072-06  0.426
2007 Kakegawa W, Miyazaki T, Hirai H, Motohashi J, Mishina M, Watanabe M, Yuzaki M. Ca2+ permeability of the channel pore is not essential for the delta2 glutamate receptor to regulate synaptic plasticity and motor coordination. The Journal of Physiology. 579: 729-35. PMID 17255161 DOI: 10.1113/Jphysiol.2006.127100  0.62
2006 Hisatsune C, Kuroda Y, Akagi T, Torashima T, Hirai H, Hashikawa T, Inoue T, Mikoshiba K. Inositol 1,4,5-trisphosphate receptor type 1 in granule cells, not in Purkinje cells, regulates the dendritic morphology of Purkinje cells through brain-derived neurotrophic factor production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10916-24. PMID 17050730 DOI: 10.1523/Jneurosci.3269-06.2006  0.441
2006 Torashima T, Yamada N, Itoh M, Yamamoto A, Hirai H. Exposure of lentiviral vectors to subneutral pH shifts the tropism from Purkinje cell to Bergmann glia. The European Journal of Neuroscience. 24: 371-80. PMID 16836635 DOI: 10.1111/J.1460-9568.2006.04927.X  0.348
2006 Torashima T, Okoyama S, Nishizaki T, Hirai H. In vivo transduction of murine cerebellar Purkinje cells by HIV-derived lentiviral vectors. Brain Research. 1082: 11-22. PMID 16516872 DOI: 10.1016/J.Brainres.2006.01.104  0.376
2006 Qin Q, Inatome R, Hotta A, Kojima M, Yamamura H, Hirai H, Yoshizawa T, Tanaka H, Fukami K, Yanagi S. A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein. The Journal of Cell Biology. 172: 497-504. PMID 16461359 DOI: 10.1083/Jcb.200505079  0.31
2005 Hirai H, Pang Z, Bao D, Miyazaki T, Li L, Miura E, Parris J, Rong Y, Watanabe M, Yuzaki M, Morgan JI. Cbln1 is essential for synaptic integrity and plasticity in the cerebellum. Nature Neuroscience. 8: 1534-41. PMID 16234806 DOI: 10.1038/Nn1576  0.63
2005 Hirai H, Miyazaki T, Kakegawa W, Matsuda S, Mishina M, Watanabe M, Yuzaki M. Rescue of abnormal phenotypes of the delta2 glutamate receptor-null mice by mutant delta2 transgenes. Embo Reports. 6: 90-5. PMID 15592450 DOI: 10.1038/Sj.Embor.7400312  0.635
2003 Hirai H, Launey T, Mikawa S, Torashima T, Yanagihara D, Kasaura T, Miyamoto A, Yuzaki M. New role of delta2-glutamate receptors in AMPA receptor trafficking and cerebellar function. Nature Neuroscience. 6: 869-76. PMID 12833050 DOI: 10.1038/Nn1086  0.63
2003 Matsuda S, Launey T, Mikawa S, Hirai H. Erratum: Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons (EMBO Journal (2000) 19 (2765-2774)) The Embo Journal. 22. DOI: 10.1093/Emboj/Cdg049  0.325
2002 Matsuda S, Mikawa S, Hirai H. Phosphorylation of Serine‐880 in GluR2 by Protein Kinase C Prevents Its C Terminus from Binding with Glutamate Receptor‐Interacting Protein Journal of Neurochemistry. 73: 1765-1768. PMID 10501226 DOI: 10.1046/J.1471-4159.1999.731765.X  0.353
2002 Hirai H, Launey T, Mikawa S, Yanagihara D, Kasaura T, Miyamoto A, Yuzaki M. Antibody against a putative ligand-binding site reveals delta2 glutamate receptor function Annals of the New York Academy of Sciences. 978: 519. DOI: 10.1111/J.1749-6632.2002.Tb07600.X  0.544
2001 Hirai H. Ca2+-dependent regulation of synaptic delta2 glutamate receptor density in cultured rat Purkinje neurons. European Journal of Neuroscience. 14: 73-82. PMID 11488951 DOI: 10.1046/J.0953-816X.2001.01630.X  0.387
2001 Hirai H. Modification of AMPA receptor clustering regulates cerebellar synaptic plasticity. Neuroscience Research. 39: 261-7. PMID 11248365 DOI: 10.1016/S0168-0102(00)00237-6  0.393
2000 Hirai H, Launey T. The regulatory connection between the activity of granule cell NMDA receptors and dendritic differentiation of cerebellar Purkinje cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 5217-24. PMID 10884305 DOI: 10.1523/Jneurosci.20-14-05217.2000  0.414
2000 Matsuda S, Launey T, Mikawa S, Hirai H. Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons. The Embo Journal. 19: 2765-74. PMID 10856222 DOI: 10.1093/Emboj/19.12.2765  0.383
2000 Hirai H. Clustering of δ glutamate receptors is regulated by the actin cytoskeleton in the dendritic spines of cultured rat Purkinje cells European Journal of Neuroscience. 12: 563-570. PMID 10712635 DOI: 10.1046/J.1460-9568.2000.00938.X  0.365
2000 Hirai H, Matsuda S. Interaction of the C-terminal domain of delta glutamate receptor with spectrin in the dendritic spines of cultured Purkinje cells. Neuroscience Research. 34: 281-7. PMID 10576550 DOI: 10.1016/S0168-0102(99)00061-9  0.38
1999 Hirai H, Yoshioka K, Yamada K. Regulation of Phosphatidylcholine Biosynthesis by mGluR1α Expressed in Human Embryonic Kidney 293 Cells— A 31P-NMR Study Molecular and Cellular Neuroscience. 14: 444-454. PMID 10656252 DOI: 10.1006/Mcne.1999.0797  0.38
1999 Matsuda S, Hirai H. The clustering of NMDA receptor NR1 subunit is regulated by the interaction between the C-terminal exon cassettes and the cytoskeleton. Neuroscience Research. 34: 157-63. PMID 10515258 DOI: 10.1016/S0168-0102(99)00046-2  0.342
1998 Hirai H, Torashima T, Ito M, Yoshioka K, Yamada K. Phospholipid metabolism activated by the stimulation of glutamate receptors in HEK 293 cells stably expressing glutamate receptors-31P-NMR study- Neuroscience Research. 31: S87. DOI: 10.1016/S0168-0102(98)81894-4  0.345
1997 Laube B, Hirai H, Sturgess M, Betz H, Kuhse J. Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit. Neuron. 18: 493-503. PMID 9115742 DOI: 10.1016/S0896-6273(00)81249-0  0.321
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