| Year |
Citation |
Score |
| 2020 |
Jian Y, Merceron R, De Munck S, Forbes HE, Hulpia F, Risseeuw MDP, Van Hecke K, Savvides SN, Munier-Lehmann H, Boshoff HIM, Van Calenbergh S. Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents. European Journal of Medicinal Chemistry. 206: 112659. PMID 32823003 DOI: 10.1016/J.Ejmech.2020.112659 |
0.336 |
|
| 2019 |
Persson EK, Verstraete K, Heyndrickx I, Gevaert E, Aegerter H, Percier JM, Deswarte K, Verschueren KHG, Dansercoer A, Gras D, Chanez P, Bachert C, Gonçalves A, Van Gorp H, De Haard H, ... ... Savvides SN, et al. Protein crystallization promotes type 2 immunity and is reversible by antibody treatment. Science (New York, N.Y.). 364. PMID 31123109 DOI: 10.1126/Science.Aaw4295 |
0.325 |
|
| 2019 |
Dejonghe W, Sharma I, Denoo B, De Munck S, Lu Q, Mishev K, Bulut H, Mylle E, De Rycke R, Vasileva M, Savatin DV, Nerinckx W, Staes A, Drozdzecki A, Audenaert D, ... ... Savvides SN, et al. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nature Chemical Biology. PMID 31011214 DOI: 10.1038/S41589-019-0262-1 |
0.327 |
|
| 2019 |
Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, Van Beeumen J, Svergun D, Gutsche I, Savvides SN, Verstraete K. Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature. PMID 30944476 DOI: 10.2210/Pdb6Hxh/Pdb |
0.378 |
|
| 2018 |
Fulara A, Vandenberghe I, Read RJ, Devreese B, Savvides SN. Structure and oligomerization of the periplasmic domain of GspL from the type II secretion system of Pseudomonas aeruginosa. Scientific Reports. 8: 16760. PMID 30425318 DOI: 10.1038/S41598-018-34956-W |
0.365 |
|
| 2018 |
Mishev K, Lu Q, Denoo B, Peurois F, Dejonghe W, Hullaert J, De Rycke RM, Boeren S, Bretou M, De Munck S, Sharma IS, Goodman K, Kalinowska K, Storme V, Nguyen L, ... ... Savvides S, et al. Nonselective chemical inhibition of Sec7 domain-containing ARF GEFs in Arabidopsis. The Plant Cell. PMID 30018157 DOI: 10.1105/Tpc.18.00145 |
0.347 |
|
| 2018 |
Song L, Merceron R, Gracia B, Quintana AL, Risseeuw MDP, Hulpia F, Cos P, Ainsa JA, Munier-Lehmann H, Savvides SN, Van Calenbergh S. Structure Guided Lead Generation towards non-chiral M. tuberculosis Thymidylate Kinase Inhibitors. Journal of Medicinal Chemistry. PMID 29510037 DOI: 10.1021/Acs.Jmedchem.7B01570 |
0.345 |
|
| 2017 |
Van Rompaey D, Verstraete K, Peelman F, Savvides SN, Augustyns K, Van Der Veken P, De Winter H. Virtual screening for inhibitors of the human TSLP:TSLPR interaction. Scientific Reports. 7: 17211. PMID 29222519 DOI: 10.1038/S41598-017-17620-7 |
0.348 |
|
| 2017 |
Elegheert J, Brigé A, Van Beeumen J, Savvides SN. Structural dissection of Shewanella oneidensis old yellow enzyme 4 bound to a Meisenheimer complex and (nitro)phenolic ligands. Febs Letters. 591: 3391-3401. PMID 28869767 DOI: 10.1002/1873-3468.12833 |
0.442 |
|
| 2017 |
Verstraete K, Peelman F, Braun H, Lopez J, Van Rompaey D, Dansercoer A, Vandenberghe I, Pauwels K, Tavernier J, Lambrecht BN, Hammad H, De Winter H, Beyaert R, Lippens G, Savvides SN. Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma. Nature Communications. 8: 14937. PMID 28368013 DOI: 10.1038/Ncomms14937 |
0.335 |
|
| 2016 |
Felix J, Kandiah E, De Munck S, Bloch Y, van Zundert GC, Pauwels K, Dansercoer A, Novanska K, Read RJ, Bonvin AM, Vergauwen B, Verstraete K, Gutsche I, Savvides SN. Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF. Nature Communications. 7: 13228. PMID 27819269 DOI: 10.1038/Ncomms13228 |
0.335 |
|
| 2015 |
Felix J, De Munck S, Verstraete K, Meuris L, Callewaert N, Elegheert J, Savvides SN. Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure (London, England : 1993). 23: 1621-1631. PMID 26235028 DOI: 10.1016/J.Str.2015.06.019 |
0.335 |
|
| 2014 |
Desmet J, Verstraete K, Bloch Y, Lorent E, Wen Y, Devreese B, Vandenbroucke K, Loverix S, Hettmann T, Deroo S, Somers K, Henderikx P, Lasters I, Savvides SN. Structural basis of IL-23 antagonism by an Alphabody protein scaffold. Nature Communications. 5: 5237. PMID 25354530 DOI: 10.1038/Ncomms6237 |
0.367 |
|
| 2014 |
Wen Y, Behiels E, Felix J, Elegheert J, Vergauwen B, Devreese B, Savvides SN. The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence. Nucleic Acids Research. 42: 10134-47. PMID 25056321 DOI: 10.1093/Nar/Gku665 |
0.336 |
|
| 2014 |
Moharana K, Zabeau L, Peelman F, Ringler P, Stahlberg H, Tavernier J, Savvides SN. Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins. Structure (London, England : 1993). 22: 866-77. PMID 24882746 DOI: 10.1016/J.Str.2014.04.012 |
0.357 |
|
| 2014 |
Dondelinger Y, Declercq W, Montessuit S, Roelandt R, Goncalves A, Bruggeman I, Hulpiau P, Weber K, Sehon CA, Marquis RW, Bertin J, Gough PJ, Savvides S, Martinou JC, Bertrand MJ, et al. MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates. Cell Reports. 7: 971-81. PMID 24813885 DOI: 10.1016/J.Celrep.2014.04.026 |
0.302 |
|
| 2014 |
Verstraete K, van Schie L, Vyncke L, Bloch Y, Tavernier J, Pauwels E, Peelman F, Savvides SN. Structural basis of the proinflammatory signaling complex mediated by TSLP. Nature Structural & Molecular Biology. 21: 375-82. PMID 24632570 DOI: 10.1038/Nsmb.2794 |
0.334 |
|
| 2014 |
Al Atalah B, Vanderschaeghe D, Bloch Y, Proost P, Plas K, Callewaert N, Savvides SN, Van Damme EJ. Characterization of a type D1A EUL-related lectin from rice expressed in Pichia pastoris. Biological Chemistry. 395: 413-24. PMID 24231122 DOI: 10.1515/Hsz-2013-0267 |
0.322 |
|
| 2014 |
Desmet J, Verstraete K, Bloch Y, Lorent E, Wen Y, Devreese B, Vandenbroucke K, Loverix S, Hettmann T, Deroo S, Somers K, Henderikx P, Lasters I, Savvides S. Structural Basis Of Il-23 Antagonism By An Alphabody Protein Nature Communications. 5: 5237. DOI: 10.2210/Pdb5Mj4/Pdb |
0.303 |
|
| 2014 |
Felix J, Moharana K, Demunck S, Pannecoucke E, Elegheert J, Verstraete K, Shkumatov A, Svergun D, Gutsche I, Savvides S. Plasticity and cooperativity of cytokine-receptor assemblies at the cell surface Acta Crystallographica Section a Foundations and Advances. 70: C405-C405. DOI: 10.1107/S2053273314095941 |
0.348 |
|
| 2013 |
Vergauwen B, Verstraete K, Senadheera DB, Dansercoer A, Cvitkovitch DG, Guédon E, Savvides SN. Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans. Molecular Microbiology. 89: 288-303. PMID 23701283 DOI: 10.1111/Mmi.12274 |
0.405 |
|
| 2013 |
Felix J, Elegheert J, Gutsche I, Shkumatov AV, Wen Y, Bracke N, Pannecoucke E, Vandenberghe I, Devreese B, Svergun DI, Pauwels E, Vergauwen B, Savvides SN. Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor. Structure (London, England : 1993). 21: 528-39. PMID 23478061 DOI: 10.1016/J.Str.2013.01.018 |
0.309 |
|
| 2013 |
Buysschaert G, Verstraete K, Savvides SN, Vergauwen B. Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference. The Febs Journal. 280: 1358-70. PMID 23311896 DOI: 10.1111/Febs.12128 |
0.432 |
|
| 2013 |
Van der Meeren R, Wen Y, Van Gelder P, Tommassen J, Devreese B, Savvides SN. New insights into the assembly of bacterial secretins: structural studies of the periplasmic domain of XcpQ from Pseudomonas aeruginosa. The Journal of Biological Chemistry. 288: 1214-25. PMID 23188826 DOI: 10.1074/Jbc.M112.432096 |
0.337 |
|
| 2012 |
Verstraete K, Savvides SN. Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases. Nature Reviews. Cancer. 12: 753-66. PMID 23076159 DOI: 10.1038/Nrc3371 |
0.316 |
|
| 2012 |
Elegheert J, Bracke N, Pouliot P, Gutsche I, Shkumatov AV, Tarbouriech N, Verstraete K, Bekaert A, Burmeister WP, Svergun DI, Lambrecht BN, Vergauwen B, Savvides SN. Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1. Nature Structural & Molecular Biology. 19: 938-47. PMID 22902366 DOI: 10.1038/Nsmb.2367 |
0.328 |
|
| 2012 |
Buysschaert G, Verstraete K, Savvides SN, Vergauwen B. Crystallization of an atypical short-chain dehydrogenase from Vibrio vulnificus lacking the conserved catalytic tetrad. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 771-4. PMID 22750861 DOI: 10.1107/S1744309112018672 |
0.443 |
|
| 2012 |
Stout J, De Vos D, Vergauwen B, Savvides SN. Glutathione biosynthesis in bacteria by bifunctional GshF is driven by a modular structure featuring a novel hybrid ATP-grasp fold. Journal of Molecular Biology. 416: 486-94. PMID 22226834 DOI: 10.1016/J.Jmb.2011.12.046 |
0.425 |
|
| 2011 |
Elegheert J, Desfosses A, Shkumatov AV, Wu X, Bracke N, Verstraete K, Van Craenenbroeck K, Brooks BR, Svergun DI, Vergauwen B, Gutsche I, Savvides SN. Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles. Structure (London, England : 1993). 19: 1762-72. PMID 22153499 DOI: 10.1016/J.Str.2011.10.012 |
0.331 |
|
| 2011 |
Vergauwen B, Van der Meeren R, Dansercoer A, Savvides SN. Delineation of the Pasteurellaceae-specific GbpA-family of glutathione-binding proteins. Bmc Biochemistry. 12: 59. PMID 22087650 DOI: 10.1186/1471-2091-12-59 |
0.327 |
|
| 2011 |
Verstraete K, Remmerie B, Elegheert J, Lintermans B, Haegeman G, Vanhoenacker P, Van Craenenbroeck K, Savvides SN. Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 325-31. PMID 21393836 DOI: 10.1107/S1744309111003319 |
0.359 |
|
| 2011 |
Verstraete K, Vandriessche G, Januar M, Elegheert J, Shkumatov AV, Desfosses A, Van Craenenbroeck K, Svergun DI, Gutsche I, Vergauwen B, Savvides SN. Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex. Blood. 118: 60-8. PMID 21389326 DOI: 10.1182/Blood-2011-01-329532 |
0.349 |
|
| 2010 |
Vergauwen B, Elegheert J, Dansercoer A, Devreese B, Savvides SN. Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA. Proceedings of the National Academy of Sciences of the United States of America. 107: 13270-5. PMID 20628015 DOI: 10.1073/Pnas.1005198107 |
0.399 |
|
| 2010 |
Remans K, Pauwels K, van Ulsen P, Buts L, Cornelis P, Tommassen J, Savvides SN, Decanniere K, Van Gelder P. Hydrophobic surface patches on LolA of Pseudomonas aeruginosa are essential for lipoprotein binding. Journal of Molecular Biology. 401: 921-30. PMID 20620146 DOI: 10.1016/J.Jmb.2010.06.067 |
0.345 |
|
| 2010 |
De Groeve MR, Remmery L, Van Hoorebeke A, Stout J, Desmet T, Savvides SN, Soetaert W. Construction of cellobiose phosphorylase variants with broadened acceptor specificity towards anomerically substituted glucosides. Biotechnology and Bioengineering. 107: 413-20. PMID 20517986 DOI: 10.1002/Bit.22818 |
0.342 |
|
| 2010 |
Van Hoorebeke A, Stout J, Van der Meeren R, Kyndt J, Van Beeumen J, Savvides SN. Crystallization and X-ray diffraction studies of inverting trehalose phosphorylase from Thermoanaerobacter sp. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 442-7. PMID 20383018 DOI: 10.1107/S1744309110005749 |
0.352 |
|
| 2010 |
Van Hoorebeke A, Stout J, Kyndt J, De Groeve M, Dix I, Desmet T, Soetaert W, Van Beeumen J, Savvides SN. Crystallization and X-ray diffraction studies of cellobiose phosphorylase from Cellulomonas uda. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 346-51. PMID 20208178 DOI: 10.1107/S1744309110002642 |
0.334 |
|
| 2010 |
De Groeve MR, Tran GH, Van Hoorebeke A, Stout J, Desmet T, Savvides SN, Soetaert W. Development and application of a screening assay for glycoside phosphorylases. Analytical Biochemistry. 401: 162-7. PMID 20188057 DOI: 10.1016/J.Ab.2010.02.028 |
0.312 |
|
| 2010 |
Elegheert J, van den Hemel D, Dix I, Stout J, Van Beeumen J, Brigé A, Savvides SN. Towards structural studies of the old yellow enzyme homologue SYE4 from Shewanella oneidensis and its complexes at atomic resolution. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 85-90. PMID 20057079 DOI: 10.1107/S1744309109050386 |
0.402 |
|
| 2009 |
Theunissen S, Vergauwen B, De Smet L, Van Beeumen J, Van Gelder P, Savvides SN. The agglutination protein AggA from Shewanella oneidensis MR-1 is a TolC-like protein and forms active channels in vitro. Biochemical and Biophysical Research Communications. 386: 380-5. PMID 19524550 DOI: 10.1016/J.Bbrc.2009.06.044 |
0.329 |
|
| 2009 |
Verstraete K, Koch S, Ertugrul S, Vandenberghe I, Aerts M, Vandriessche G, Thiede C, Savvides SN. Efficient production of bioactive recombinant human Flt3 ligand in E. coli. The Protein Journal. 28: 57-65. PMID 19184382 DOI: 10.1007/S10930-009-9164-5 |
0.319 |
|
| 2009 |
Fouquaert E, Smith DF, Peumans WJ, Proost P, Balzarini J, Savvides SN, Damme EJ. Related lectins from snowdrop and maize differ in their carbohydrate-binding specificity. Biochemical and Biophysical Research Communications. 380: 260-5. PMID 19167365 DOI: 10.1016/J.Bbrc.2009.01.048 |
0.32 |
|
| 2009 |
Rahlfs S, Koncarevic S, Iozef R, Mailu BM, Savvides SN, Schirmer RH, Becker K. Myristoylated adenylate kinase-2 of Plasmodium falciparum forms a heterodimer with myristoyltransferase. Molecular and Biochemical Parasitology. 163: 77-84. PMID 18973776 DOI: 10.1016/J.Molbiopara.2008.09.008 |
0.33 |
|
| 2008 |
Berkholz DS, Faber HR, Savvides SN, Karplus PA. Catalytic cycle of human glutathione reductase near 1 A resolution. Journal of Molecular Biology. 382: 371-84. PMID 18638483 DOI: 10.1016/J.Jmb.2008.06.083 |
0.716 |
|
| 2008 |
Remmerie B, Vandenbroucke K, De Smet L, Carpentier W, De Vos D, Stout J, Van Beeumen J, Savvides SN. Expression, purification, crystallization and structure determination of two glutathione S-transferase-like proteins from Shewanella oneidensis. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 548-53. PMID 18540073 DOI: 10.1107/S1744309108014589 |
0.39 |
|
| 2008 |
Fouquaert E, Peumans WJ, Smith DF, Proost P, Savvides SN, Van Damme EJ. The "old" Euonymus europaeus agglutinin represents a novel family of ubiquitous plant proteins. Plant Physiology. 147: 1316-24. PMID 18451263 DOI: 10.1104/Pp.108.116764 |
0.333 |
|
| 2007 |
Van Petegem F, De Vos D, Savvides S, Vergauwen B, Van Beeumen J. Understanding nicotinamide dinucleotide cofactor and substrate specificity in class I flavoprotein disulfide oxidoreductases: crystallographic analysis of a glutathione amide reductase. Journal of Molecular Biology. 374: 883-9. PMID 17977556 DOI: 10.1016/J.Jmb.2007.09.072 |
0.444 |
|
| 2007 |
Greco MN, Hawkins MJ, Powell ET, Almond HR, De Garavilla L, Hall J, Minor LK, Wang Y, Corcoran TW, Di Cera E, Cantwell AM, Savvides SN, Damiano BP, Maryanoff BE. Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase Journal of Medicinal Chemistry. 50: 1727-1730. PMID 17361995 DOI: 10.1021/Jm0700619 |
0.301 |
|
| 2007 |
Stout J, Van Driessche G, Savvides SN, Van Beeumen J. X-ray crystallographic analysis of the sulfur carrier protein SoxY from Chlorobium limicola f. thiosulfatophilum reveals a tetrameric structure. Protein Science : a Publication of the Protein Society. 16: 589-601. PMID 17327392 DOI: 10.1110/Ps.062633607 |
0.424 |
|
| 2007 |
Kyndt JA, Savvides SN, Memmi S, Koh M, Fitch JC, Meyer TE, Heyn MP, Van Beeumen JJ, Cusanovich MA. Structural role of tyrosine 98 in photoactive yellow protein: Effects on fluorescence, gateway, and photocycle recovery Biochemistry. 46: 95-105. PMID 17198379 DOI: 10.1021/Bi061867Y |
0.31 |
|
| 2006 |
Stout J, De Smet L, Panjikar S, Weiss MS, Savvides SN, Van Beeumen J. Crystallization, preliminary crystallographic analysis and phasing of the thiosulfate-binding protein SoxY from Chlorobium limicola f. thiosulfatophilum. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 1093-6. PMID 17077486 DOI: 10.1107/S1744309106036566 |
0.368 |
|
| 2006 |
van den Hemel D, Brigé A, Savvides SN, Van Beeumen J. Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding. The Journal of Biological Chemistry. 281: 28152-61. PMID 16857682 DOI: 10.1074/Jbc.M603946200 |
0.446 |
|
| 2006 |
De Vos D, Collins T, Nerinckx W, Savvides SN, Claeyssens M, Gerday C, Feller G, Van Beeumen J. Oligosaccharide binding in family 8 glycosidases: crystal structures of active-site mutants of the beta-1,4-xylanase pXyl from Pseudoaltermonas haloplanktis TAH3a in complex with substrate and product. Biochemistry. 45: 4797-807. PMID 16605248 DOI: 10.1021/Bi052193E |
0.411 |
|
| 2006 |
Pauwels K, Lustig A, Wyns L, Tommassen J, Savvides SN, Van Gelder P. Structure of a membrane-based steric chaperone in complex with its lipase substrate. Nature Structural & Molecular Biology. 13: 374-5. PMID 16518399 DOI: 10.1038/Nsmb1065 |
0.395 |
|
| 2006 |
De Smet L, Savvides SN, Van Horen E, Pettigrew G, Van Beeumen JJ. Structural and mutagenesis studies on the cytochrome c peroxidase from Rhodobacter capsulatus provide new insights into structure-function relationships of bacterial di-heme peroxidases. The Journal of Biological Chemistry. 281: 4371-9. PMID 16314410 DOI: 10.1074/Jbc.M509582200 |
0.441 |
|
| 2006 |
Stout J, Savvides SN, De Smet L, Vergauwen B, Van Beeumen J. Structural insights in the SoxY protein ofChlorobium limicolaf.thiosulfatophilum Acta Crystallographica Section a Foundations of Crystallography. 62: s299-s299. DOI: 10.1107/S0108767306094037 |
0.326 |
|
| 2005 |
Agapay RC, Savvides SN, Van Driessche G, Devreese B, Van Beeumen J, Jongejan JA, Hagen WR. Expression, purification, crystallization and preliminary crystallographic analysis of a stand-alone RAM domain with hydrolytic activity from the hyperthermophile Pyrococcus furiosus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 914-6. PMID 16511194 DOI: 10.1107/S1744309105028393 |
0.349 |
|
| 2005 |
De Vos D, Hulpiau P, Vergauwen B, Savvides SN, Van Beeumen J. Expression, purification, crystallization and preliminary X-ray crystallographic studies of a cold-adapted aspartate carbamoyltransferase from Moritella profunda. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 279-81. PMID 16511017 DOI: 10.1107/S174430910500285X |
0.401 |
|
| 2005 |
Collins T, De Vos D, Hoyoux A, Savvides SN, Gerday C, Van Beeumen J, Feller G. Study of the active site residues of a glycoside hydrolase family 8 xylanase. Journal of Molecular Biology. 354: 425-35. PMID 16246370 DOI: 10.1016/J.Jmb.2005.09.064 |
0.382 |
|
| 2005 |
Dolashka-Angelova P, Dolashki A, Savvides SN, Hristova R, Van Beeumen J, Voelter W, Devreese B, Weser U, Di Muro P, Salvato B, Stevanovic S. Structure of hemocyanin subunit CaeSS2 of the crustacean Mediterranean crab Carcinus aestuarii. Journal of Biochemistry. 138: 303-12. PMID 16169881 DOI: 10.1093/Jb/Mvi130 |
0.38 |
|
| 2004 |
Pineda AO, Zhang E, Guinto ER, Savvides SN, Tulinsky A, Di Cera E. Crystal structure of the thrombin mutant D221A/D222K: the Asp222:Arg187 ion-pair stabilizes the fast form. Biophysical Chemistry. 112: 253-6. PMID 15572256 DOI: 10.1016/J.Bpc.2004.07.027 |
0.364 |
|
| 2004 |
Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. The Journal of Biological Chemistry. 279: 39824-8. PMID 15252033 DOI: 10.1074/Jbc.M407272200 |
0.437 |
|
| 2004 |
Savvides SN, Raghunathan S, Fütterer K, Kozlov AG, Lohman TM, Waksman G. The C-terminal domain of full-length E. coli SSB is disordered even when bound to DNA. Protein Science : a Publication of the Protein Society. 13: 1942-7. PMID 15169953 DOI: 10.1110/Ps.04661904 |
0.341 |
|
| 2003 |
Sarma GN, Savvides SN, Becker K, Schirmer M, Schirmer RH, Karplus PA. Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development. Journal of Molecular Biology. 328: 893-907. PMID 12729762 DOI: 10.1016/S0022-2836(03)00347-4 |
0.608 |
|
| 2003 |
Savvides SN, Yeo HJ, Beck MR, Blaesing F, Lurz R, Lanka E, Buhrdorf R, Fischer W, Haas R, Waksman G. VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretion. The Embo Journal. 22: 1969-80. PMID 12727865 DOI: 10.1093/Emboj/Cdg223 |
0.387 |
|
| 2002 |
Pineda AO, Savvides SN, Waksman G, Di Cera E. Crystal structure of the anticoagulant slow form of thrombin. The Journal of Biological Chemistry. 277: 40177-80. PMID 12205081 DOI: 10.1074/Jbc.C200465200 |
0.428 |
|
| 2002 |
Savvides SN, Scheiwein M, Bohme CC, Arteel GE, Karplus PA, Becker K, Schirmer RH. Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite. The Journal of Biological Chemistry. 277: 2779-84. PMID 11705998 DOI: 10.1074/Jbc.M108190200 |
0.626 |
|
| 2002 |
Yeo H, Savvides S, Lanka E, Waksman G. Crystal structure of the hexameric traffic ATPase of theHelicobacter pyloritype IV secretion system: insights into function and mode of action Acta Crystallographica Section a Foundations of Crystallography. 58: c303-c303. DOI: 10.1107/S0108767302097088 |
0.326 |
|
| 2000 |
Yeo HJ, Savvides SN, Herr AB, Lanka E, Waksman G. Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system Molecular Cell. 6: 1461-1472. PMID 11163218 DOI: 10.1016/S1097-2765(00)00142-8 |
0.37 |
|
| 2000 |
Savvides SN, Boone T, Karplus PA. Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots Nature Structural Biology. 7: 486-491. PMID 10881197 DOI: 10.1038/75896 |
0.566 |
|
| 1998 |
Becker K, Savvides SN, Keese M, Schirmer RH, Karplus PA. Enzyme inactivation through sulfhydryl oxidation by physiologic NO- carriers Nature Structural Biology. 5: 267-271. PMID 9546215 DOI: 10.1038/Nsb0498-267 |
0.596 |
|
| 1996 |
Faerman CH, Savvides SN, Strickland C, Breidenbach MA, Ponasik JA, Ganem B, Ripoll D, Krauth-Siegel RL, Karplus PA. Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors. Bioorganic & Medicinal Chemistry. 4: 1247-53. PMID 8879546 DOI: 10.1016/0968-0896(96)00120-4 |
0.567 |
|
| 1996 |
Savvides SN, Karplus PA. Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitor Journal of Biological Chemistry. 271: 8101-8107. PMID 8626496 DOI: 10.1074/Jbc.271.14.8101 |
0.605 |
|
| 1996 |
Savvides SN, Karplus PA. Characterization of a non-competitive inhibitor of human glutathione reductase Acta Crystallographica Section a Foundations of Crystallography. 52: C206-C207. DOI: 10.1107/S010876739609109X |
0.496 |
|
| 1995 |
Strickland CL, Puchalski R, Savvides SN, Karplus PA. Overexpression of Crithidia fasciculata trypanothione reductase and crystallization using a novel geometry. Acta Crystallographica. Section D, Biological Crystallography. 51: 337-41. PMID 15299300 DOI: 10.1107/S0907444994010772 |
0.58 |
|
| 1995 |
Ponasik JA, Strickland C, Faerman C, Savvides S, Karplus PA, Ganem B. Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase. The Biochemical Journal. 311: 371-5. PMID 7487870 DOI: 10.1042/Bj3110371 |
0.57 |
|
| 1995 |
Strickland CL, Puchalski R, Savvides SN, Karplus PA. Overexpression of Crithidia fasciculata trypanothione reductase and crystallization using a novel ggeometry Acta Crystallographica - Section D Biological Crystallography. 51: 337-341. DOI: 10.1107/S0907444994010772 |
0.5 |
|
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