Dorian B. McGavern, Ph.D. - Publications

Affiliations: 
Mayo Clinic, Rochester, MN, United States 
 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
 National Institutes of Health-NINDS 

137 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Fitzpatrick Z, Ghabdan Zanluqui N, Rosenblum JS, Tuong ZK, Lee CYC, Chandrashekhar V, Negro-Demontel ML, Stewart AP, Posner DA, Buckley M, Allinson KSJ, Mastorakos P, Chittiboina P, Maric D, Donahue D, ... ... McGavern DB, et al. Venous-plexus-associated lymphoid hubs support meningeal humoral immunity. Nature. PMID 38509366 DOI: 10.1038/s41586-024-07202-9  0.352
2023 Fernando N, Gopalakrishnan J, Behensky A, Reich L, Liu C, Bass V, Bono M, Montgomery W, De Pace R, Mattapallil M, Nagarajan V, Brooks S, Maric D, Caspi RR, McGavern DB, et al. Single-cell multiomic analysis reveals the involvement of Type I interferon-responsive CD8+ T cells in amyloid beta-associated memory loss. Biorxiv : the Preprint Server For Biology. PMID 37090642 DOI: 10.1101/2023.03.18.533293  0.322
2023 Mason H, Rai G, Kozyr A, De Jonge N, Gliniewicz E, Berg LJ, Wald G, Dorrier C, Henderson MJ, Zakharov A, Dyson T, Audley J, Pettinato AM, Padilha EC, Shah P, ... ... McGavern DB, et al. Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury. Redox Biology. 60: 102611. PMID 36709665 DOI: 10.1016/j.redox.2023.102611  0.778
2022 Zhang Y, Bailey JT, Xu E, Singh K, Lavaert M, Link VM, D'Souza S, Hafiz A, Cao J, Cao G, Sant'Angelo DB, Sun W, Belkaid Y, Bhandoola A, McGavern DB, et al. Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function. Nature Immunology. PMID 36411380 DOI: 10.1038/s41590-022-01349-1  0.39
2022 Rebejac J, Eme-Scolan E, Arnaud Paroutaud L, Kharbouche S, Teleman M, Spinelli L, Gallo E, Roussel-Queval A, Zarubica A, Sansoni A, Bardin Q, Hoest P, Michallet MC, Brousse C, Crozat K, ... ... McGavern DB, et al. Meningeal macrophages protect against viral neuroinfection. Immunity. 55: 2103-2117.e10. PMID 36323311 DOI: 10.1016/j.immuni.2022.10.005  0.802
2022 Christian DA, Adams TA, Shallberg LA, Phan AT, Smith TE, Abraha M, Perry J, Ruthel G, Clark JT, Pritchard GH, Aronson LR, Gossa S, McGavern DB, Kedl RM, Hunter CA. cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory. Science Immunology. 7: eabq7432. PMID 36179012 DOI: 10.1126/sciimmunol.abq7432  0.409
2022 Mason HD, McGavern DB. How the immune system shapes neurodegenerative diseases. Trends in Neurosciences. 45: 733-748. PMID 36075783 DOI: 10.1016/j.tins.2022.08.001  0.798
2022 Ampie L, McGavern DB. Immunological defense of CNS barriers against infections. Immunity. 55: 781-799. PMID 35545028 DOI: 10.1016/j.immuni.2022.04.012  0.349
2022 Shinzawa M, Moseman EA, Gossa S, Mano Y, Bhattacharya A, Guinter T, Alag A, Chen X, Cam M, McGavern DB, Erman B, Singer A. Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus. Nature Immunology. 23: 731-742. PMID 35523960 DOI: 10.1038/s41590-022-01187-1  0.307
2022 Liu L, Dodd S, Hunt RD, Pothayee N, Atanasijevic T, Bouraoud N, Maric D, Moseman EA, Gossa S, McGavern DB, Koretsky AP. Early detection of cerebrovascular pathology and protective antiviral immunity by MRI. Elife. 11. PMID 35510986 DOI: 10.7554/eLife.74462  0.459
2022 Dorrier CE, McGavern DB. Humoral immune defense of the central nervous system. Current Opinion in Immunology. 76: 102179. PMID 35468467 DOI: 10.1016/j.coi.2022.102179  0.363
2022 Buckley MW, McGavern DB. Immune dynamics in the CNS and its barriers during homeostasis and disease. Immunological Reviews. 306: 58-75. PMID 35067941 DOI: 10.1111/imr.13066  0.318
2022 Ciucci T, Vacchio MS, Chen T, Nie J, Chopp LB, McGavern DB, Kelly MC, Bosselut R. Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4+ T cells. The Journal of Experimental Medicine. 219. PMID 34792530 DOI: 10.1084/jem.20202343  0.307
2021 Chen H, Smith M, Herz J, Li T, Hasley R, Le Saout C, Zhu Z, Cheng J, Gronda A, Martina JA, Irusta PM, Karpova T, McGavern DB, Catalfamo M. The role of protease-activated receptor 1 signaling in CD8 T cell effector functions. Iscience. 24: 103387. PMID 34841225 DOI: 10.1016/j.isci.2021.103387  0.765
2021 Cannons JL, Villarino AV, Kapnick SM, Preite S, Shih HY, Gomez-Rodriguez J, Kaul Z, Shibata H, Reilley JM, Huang B, Handon R, McBain IT, Gossa S, Wu T, Su HC, ... McGavern DB, et al. PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8 T cells at the expense of central memory. Cell Reports. 37: 109804. PMID 34644563 DOI: 10.1016/j.celrep.2021.109804  0.333
2021 Mastorakos P, Russo MV, Zhou T, Johnson K, McGavern DB. Antimicrobial immunity impedes CNS vascular repair following brain injury. Nature Immunology. 22: 1280-1293. PMID 34556874 DOI: 10.1038/s41590-021-01012-1  0.702
2021 Vezina A, Manglani M, Morris D, Foster B, McCord M, Song H, Zhang M, Davis D, Zhang W, Bills J, Nagashima K, Shankarappa P, Kindrick J, Walbridge S, Peer CJ, ... ... McGavern DB, et al. Adenosine A2A receptor activation enhances blood-tumor barrier permeability in a rodent glioma model. Molecular Cancer Research : McR. PMID 34521765 DOI: 10.1158/1541-7786.MCR-19-0995  0.766
2021 Mason HD, Johnson AM, Mihelson NA, Mastorakos P, McGavern DB. Glia limitans superficialis oxidation and breakdown promotes cortical cell death after repeat head injury. Jci Insight. PMID 34428178 DOI: 10.1172/jci.insight.149229  0.794
2021 Mihelson N, McGavern DB. Viral Control of Glioblastoma. Viruses. 13. PMID 34209584 DOI: 10.3390/v13071264  0.803
2021 Brooks DG, Tishon A, Oldstone MBA, McGavern DB. Prevention of CD8 T Cell Deletion during Chronic Viral Infection. Viruses. 13. PMID 34206262 DOI: 10.3390/v13071189  0.574
2021 Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, ... ... McGavern DB, et al. BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8 T cells. Nature Immunology. PMID 33574619 DOI: 10.1038/s41590-021-00868-7  0.306
2021 Rosenblum JS, Wang H, Dmitriev PM, Cappadona AJ, Mastorakos P, Xu C, Jha A, Edwards N, Donahue DR, Munasinghe J, Nazari MA, Knutsen RH, Rosenblum BR, Smirniotopoulos JG, Pappo A, ... ... McGavern DB, et al. Developmental vascular malformations in EPAS1-gain-of-function syndrome. Jci Insight. PMID 33497361 DOI: 10.1172/jci.insight.144368  0.606
2021 Mastorakos P, Mihelson N, Luby M, Burks SR, Johnson K, Hsia AW, Witko J, Frank JA, Latour L, McGavern DB. Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury. Nature Neuroscience. PMID 33462481 DOI: 10.1038/s41593-020-00773-6  0.793
2021 Ebina-Shibuya R, West EE, Spolski R, Li P, Oh J, Kazemian M, Gromer D, Swanson P, Du N, McGavern DB, Leonard WJ. Thymic stromal lymphopoietin limits primary and recall CD8 T-cell anti-viral responses. Elife. 10. PMID 33439121 DOI: 10.7554/eLife.61912  0.375
2020 Fitzpatrick Z, Frazer G, Ferro A, Clare S, Bouladoux N, Ferdinand J, Tuong ZK, Negro-Demontel ML, Kumar N, Suchanek O, Tajsic T, Harcourt K, Scott K, Bashford-Rogers R, Helmy A, ... ... McGavern DB, et al. Gut-educated IgA plasma cells defend the meningeal venous sinuses. Nature. PMID 33149302 DOI: 10.1038/s41586-020-2886-4  0.814
2020 Moseman EA, Blanchard AC, Nayak D, McGavern DB. T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection. Science Immunology. 5. PMID 32503876 DOI: 10.1126/Sciimmunol.Abb1817  0.83
2020 Kolev M, West EE, Kunz N, Chauss D, Moseman EA, Rahman J, Freiwald T, Balmer ML, Lötscher J, Dimeloe S, Rosser EC, Wedderburn LR, Mayer-Barber KD, Bohrer A, Lavender P, ... ... McGavern D, et al. Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells. Immunity. 52: 513-527.e8. PMID 32187519 DOI: 10.1016/J.Immuni.2020.02.006  0.779
2020 Elsaesser HJ, Mohtashami M, Osokine I, Snell LM, Cunningham CR, Boukhaled GM, McGavern DB, Zúñiga-Pflücker JC, Brooks DG. Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection. Proceedings of the National Academy of Sciences of the United States of America. PMID 32094187 DOI: 10.1073/Pnas.1913776117  0.661
2020 Mastorakos P, McGavern D. The anatomy and immunology of vasculature in the central nervous system. Science Immunology. 4. PMID 31300479 DOI: 10.1126/Sciimmunol.Aav0492  0.714
2020 McGavern D, Asakura K, Rodriquez M. Do Antibodies Stimulate Myelin Repair in Multiple Sclerosis? The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 5: 19-28. PMID 31118550 DOI: 10.1177/107385849900500104  0.305
2020 Lai Wu AM, Gossa S, Samala R, Chung M, Gril B, Yang H, Thorsheim H, Tran A, Wei D, Isanogle K, Yang Y, Dolan E, Robinson C, Difilippantonio S, Lee M, ... ... McGavern D, et al. 29. ROLE OF AGE AND CNS MYELOID CELLS ON BREAST CANCER BRAIN METASTASIS Neuro-Oncology Advances. 2: ii5-ii5. DOI: 10.1093/noajnl/vdaa073.017  0.801
2019 Riggle BA, Manglani M, Maric D, Johnson KR, Lee MH, Lopes Abath Neto O, Taylor TE, Seydel KB, Nath A, Miller LH, McGavern DB, Pierce SK. CD8+ T cells target cerebrovasculature in children with cerebral malaria. The Journal of Clinical Investigation. PMID 31821175 DOI: 10.1172/Jci133474  0.802
2019 Magen A, Nie J, Ciucci T, Tamoutounour S, Zhao Y, Mehta M, Tran B, McGavern DB, Hannenhalli S, Bosselut R. Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4 T Cells. Cell Reports. 29: 3019-3032.e6. PMID 31801070 DOI: 10.1016/J.Celrep.2019.10.131  0.448
2019 Tiwari R, de la Torre JC, McGavern DB, Nayak D. Beyond Tethering the Viral Particles: Immunomodulatory Functions of Tetherin (). Dna and Cell Biology. PMID 31502877 DOI: 10.1089/Dna.2019.4777  0.613
2019 Collins N, Han SJ, Enamorado M, Link VM, Huang B, Moseman EA, Kishton RJ, Shannon JP, Dixit D, Schwab SR, Hickman HD, Restifo NP, McGavern DB, Schwartzberg PL, Belkaid Y. The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction. Cell. 178: 1088-1101.e15. PMID 31442402 DOI: 10.1016/J.Cell.2019.07.049  0.388
2019 Vacchio MS, Ciucci T, Gao Y, Watanabe M, Balmaceno-Criss M, McGinty MT, Huang A, Xiao Q, McConkey C, Zhao Y, Shetty J, Tran B, Pepper M, Vahedi G, Jenkins MK, ... McGavern DB, et al. A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation. Immunity. PMID 31422869 DOI: 10.1016/J.Immuni.2019.06.023  0.386
2019 Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Cheng J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, ... ... McGavern DB, et al. Single-cell RNA-seq reveals TOX as a key regulator of CD8 T cell persistence in chronic infection. Nature Immunology. PMID 31209400 DOI: 10.1038/S41590-019-0403-4  0.824
2019 Rua R, Lee JY, Silva AB, Swafford IS, Maric D, Johnson KR, McGavern DB. Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity. Nature Immunology. PMID 30886419 DOI: 10.1038/S41590-019-0344-Y  0.809
2019 Manglani M, Rua R, Hendricksen A, Braunschweig D, Gao Q, Tan W, Houser B, McGavern DB, Oh K. Method to Quantify Cytokines and Chemokines in Mouse Brain Tissue Using Bio-Plex Multiplex Immunoassays. Methods (San Diego, Calif.). PMID 30742997 DOI: 10.1016/J.Ymeth.2019.02.007  0.778
2019 Ciucci T, Vacchio MS, Gao Y, Tomassoni Ardori F, Candia J, Mehta M, Zhao Y, Tran B, Pepper M, Tessarollo L, McGavern DB, Bosselut R. The Emergence and Functional Fitness of Memory CD4 T Cells Require the Transcription Factor Thpok. Immunity. 50: 91-105.e4. PMID 30638736 DOI: 10.1016/J.Immuni.2018.12.019  0.429
2018 Preite S, Huang B, Cannons JL, McGavern DB, Schwartzberg PL. PI3K Orchestrates T Follicular Helper Cell Differentiation in a Context Dependent Manner: Implications for Autoimmunity. Frontiers in Immunology. 9: 3079. PMID 30666254 DOI: 10.3389/Fimmu.2018.03079  0.504
2018 Greenhalgh AD, Zarruk JG, Healy LM, Baskar Jesudasan SJ, Jhelum P, Salmon CK, Formanek A, Russo MV, Antel JP, McGavern DB, McColl BW, David S. Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury. Plos Biology. 16: e2005264. PMID 30332405 DOI: 10.1371/Journal.Pbio.2005264  0.36
2018 Manglani M, Gossa S, McGavern DB. Leukocyte Isolation from Brain, Spinal Cord, and Meninges for Flow Cytometric Analysis. Current Protocols in Immunology. 121: e44. PMID 30040211 DOI: 10.1002/Cpim.44  0.79
2018 Urata S, Kenyon E, Nayak D, Cubitt B, Kurosaki Y, Yasuda J, de la Torre JC, McGavern DB. BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection. Plos Pathogens. 14: e1007172. PMID 30028868 DOI: 10.1371/Journal.Ppat.1007172  0.84
2018 Kwong B, Rua R, Gao Y, Flickinger J, Wang Y, Kruhlak MJ, Zhu J, Vivier E, McGavern DB, Lazarevic V. Author Correction: T-bet-dependent NKp46 innate lymphoid cells regulate the onset of T17-induced neuroinflammation. Nature Immunology. PMID 29959442 DOI: 10.1038/S41590-018-0139-6  0.756
2018 Rua R, McGavern DB. Advances in Meningeal Immunity. Trends in Molecular Medicine. 24: 542-559. PMID 29731353 DOI: 10.1016/J.Molmed.2018.04.003  0.766
2018 Russo MV, Latour LL, McGavern DB. Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury. Nature Immunology. 19: 442-452. PMID 29662169 DOI: 10.1038/S41590-018-0086-2  0.395
2018 Manglani M, McGavern DB. Intravital Imaging of Neuroimmune Interactions Through a Thinned Skull. Current Protocols in Immunology. 120: 24.2.1-24.2.12. PMID 29512146 DOI: 10.1002/Cpim.46  0.796
2018 Manglani M, McGavern DB. New advances in CNS immunity against viral infection. Current Opinion in Virology. 28: 116-126. PMID 29289900 DOI: 10.1016/J.Coviro.2017.12.003  0.829
2017 Jassam YN, Izzy S, Whalen M, McGavern DB, El Khoury J. Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift. Neuron. 95: 1246-1265. PMID 28910616 DOI: 10.1016/J.Neuron.2017.07.010  0.39
2017 Kwong B, Rua R, Gao Y, Flickinger J, Wang Y, Kruhlak MJ, Zhu J, Vivier E, McGavern DB, Lazarevic V. T-bet-dependent NKp46(+) innate lymphoid cells regulate the onset of TH17-induced neuroinflammation. Nature Immunology. PMID 28805812 DOI: 10.1038/Ni.3816  0.774
2017 Pandya H, Shen MJ, Ichikawa DM, Sedlock AB, Choi Y, Johnson KR, Kim G, Brown MA, Elkahloun AG, Maric D, Sweeney CL, Gossa S, Malech HL, McGavern DB, Park JK. Differentiation of human and murine induced pluripotent stem cells to microglia-like cells. Nature Neuroscience. PMID 28253233 DOI: 10.1038/Nn.4534  0.801
2016 Wu T, Ji Y, Moseman EA, Xu HC, Manglani M, Kirby M, Anderson SM, Handon R, Kenyon E, Elkahloun A, Wu W, Lang PA, Gattinoni L, McGavern DB, Schwartzberg PL. The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness. Science Immunology. 1. PMID 28018990 DOI: 10.1126/Sciimmunol.Aai8593  0.824
2016 Swanson PA, Hart GT, Russo MV, Nayak D, Yazew T, Peña M, Khan SM, Janse CJ, Pierce SK, McGavern DB. CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature. Plos Pathogens. 12: e1006022. PMID 27907215 DOI: 10.1371/Journal.Ppat.1006022  0.803
2016 Moseman EA, Wu T, de la Torre JC, Schwartzberg PL, McGavern DB. Type I interferon suppresses virus-specific B cell responses by modulating CD8(+) T cell differentiation. Science Immunology. 1. PMID 27812556 DOI: 10.1126/Sciimmunol.Aah3565  0.817
2016 Konradt C, Ueno N, Christian DA, Delong JH, Pritchard GH, Herz J, Bzik DJ, Koshy AA, McGavern DB, Lodoen MB, Hunter CA. Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system. Nature Microbiology. 1: 16001. PMID 27572166 DOI: 10.1038/Nmicrobiol.2016.1  0.762
2016 Russo MV, McGavern DB. Inflammatory neuroprotection following traumatic brain injury. Science (New York, N.Y.). 353: 783-5. PMID 27540166 DOI: 10.1126/Science.Aaf6260  0.358
2016 Huber BR, Meabon JS, Hoffer ZS, Zhang J, Hoekstra JG, Pagulayan KF, McMillan PJ, Mayer CL, Banks WA, Kraemer BC, Raskind MA, McGavern DB, Peskind ER, Cook DG. Blast Exposure Causes Dynamic Microglial/Macrophage Responses and Microdomains of Brain Microvessel Dysfunction. Neuroscience. PMID 26777891 DOI: 10.1016/J.Neuroscience.2016.01.022  0.326
2015 Russo MV, McGavern DB. Immune Surveillance of the CNS following Infection and Injury. Trends in Immunology. 36: 637-650. PMID 26431941 DOI: 10.1016/J.It.2015.08.002  0.463
2015 Wu T, Shin HM, Moseman EA, Ji Y, Huang B, Harly C, Sen JM, Berg LJ, Gattinoni L, McGavern DB, Schwartzberg PL. TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. Cell Reports. PMID 26365183 DOI: 10.1016/J.Celrep.2015.08.049  0.805
2015 Lawson BR, Gonzalez-Quintial R, Eleftheriadis T, Farrar MA, Miller SD, Sauer K, McGavern DB, Kono DH, Baccala R, Theofilopoulos AN. Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation. Clinical Immunology (Orlando, Fla.). 161: 260-269. PMID 26319414 DOI: 10.1016/J.Clim.2015.08.007  0.387
2015 Wan CK, Andraski AB, Spolski R, Li P, Kazemian M, Oh J, Samsel L, Swanson PA, McGavern DB, Sampaio EP, Freeman AF, Milner JD, Holland SM, Leonard WJ. Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 9394-9. PMID 26170288 DOI: 10.1073/Pnas.1511711112  0.72
2015 Rua R, McGavern DB. Elucidation of monocyte/macrophage dynamics and function by intravital imaging. Journal of Leukocyte Biology. 98: 319-32. PMID 26162402 DOI: 10.1189/Jlb.4Ri0115-006Rr  0.75
2015 Herz J, Johnson KR, McGavern DB. Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells. The Journal of Experimental Medicine. PMID 26122661 DOI: 10.1084/Jem.20142047  0.821
2015 Torchia ML, Munitic I, Castro E, Herz J, McGavern DB, Ashwell JD. c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival. European Journal of Immunology. PMID 26096449 DOI: 10.1002/Eji.201445342  0.752
2015 Rua R, McGavern DB. Pentraxin 3 innately preps damaged tissue for wound healing. The Journal of Experimental Medicine. 212: 829. PMID 26034115 DOI: 10.1084/Jem.2126Insight2  0.692
2015 Hwang S, Palin AC, Li L, Song KD, Lee J, Herz J, Tubo N, Chu H, Pepper M, Lesourne R, Zvezdova E, Pinkhasov J, Jenkins MK, McGavern D, Love PE. TCR ITAM multiplicity is required for the generation of follicular helper T-cells. Nature Communications. 6: 6982. PMID 25959494 DOI: 10.1038/Ncomms7982  0.758
2015 Cardoso FL, Herz J, Fernandes A, Rocha J, Sepodes B, Brito MA, McGavern DB, Brites D. Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects. Journal of Neuroinflammation. 12: 82. PMID 25924675 DOI: 10.1186/S12974-015-0299-3  0.775
2015 Swanson PA, McGavern DB. Viral diseases of the central nervous system. Current Opinion in Virology. 11: 44-54. PMID 25681709 DOI: 10.1016/J.Coviro.2014.12.009  0.735
2015 Corps KN, Roth TL, McGavern DB. Inflammation and neuroprotection in traumatic brain injury. Jama Neurology. 72: 355-62. PMID 25599342 DOI: 10.1001/Jamaneurol.2014.3558  0.772
2015 Pandya H, Ichikawa DM, Shen MJ, Sedlock AB, Johnson KR, Maric D, McGavern DB, Malech HL, Park JK. Abstract 5029: Microglia differentiated from induced pluripotent stem cells treat glioma tumors in mice Cancer Research. 75: 5029-5029. DOI: 10.1158/1538-7445.Am2015-5029  0.393
2015 Wan CK, Andraski AB, Spolski R, Li P, Kazemian M, Oh J, Samsel L, Swanson PA, McGavern DB, Sampaio EP, Freeman AF, Milner JD, Holland SM, Leonard WJ. Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells Proceedings of the National Academy of Sciences of the United States of America. 112: 9394-9399. DOI: 10.1073/pnas.1511711112  0.695
2014 Gossa S, Nayak D, Zinselmeyer BH, McGavern DB. Development of an immunologically tolerated combination of fluorescent proteins for in vivo two-photon imaging. Scientific Reports. 4: 6664. PMID 25322934 DOI: 10.1038/Srep06664  0.765
2014 Nayak D, Roth TL, McGavern DB. Microglia development and function. Annual Review of Immunology. 32: 367-402. PMID 24471431 DOI: 10.1146/Annurev-Immunol-032713-120240  0.762
2014 Roth TL, Nayak D, Atanasijevic T, Koretsky AP, Latour LL, McGavern DB. Transcranial amelioration of inflammation and cell death after brain injury. Nature. 505: 223-8. PMID 24317693 DOI: 10.1038/Nature12808  0.756
2014 Herz J, Mcgavern D. Therapeutic antiviral T cells noncytopathically clear persistently infected microglia following conversion into antigen presenting cells Journal of Neuroimmunology. 275: 220-221. DOI: 10.1016/J.Jneuroim.2014.08.592  0.79
2013 Moseman EA, McGavern DB. The great balancing act: regulation and fate of antiviral T-cell interactions. Immunological Reviews. 255: 110-24. PMID 23947351 DOI: 10.1111/Imr.12093  0.806
2013 Nayak D, Johnson KR, Heydari S, Roth TL, Zinselmeyer BH, McGavern DB. Type I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous system. Plos Pathogens. 9: e1003395. PMID 23737750 DOI: 10.1371/Journal.Ppat.1003395  0.83
2013 Navarathna DH, Munasinghe J, Lizak MJ, Nayak D, McGavern DB, Roberts DD. MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasis. Nmr in Biomedicine. 26: 1125-34. PMID 23606437 DOI: 10.1002/Nbm.2926  0.585
2013 Zinselmeyer BH, Heydari S, Sacristán C, Nayak D, Cammer M, Herz J, Cheng X, Davis SJ, Dustin ML, McGavern DB. PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. The Journal of Experimental Medicine. 210: 757-74. PMID 23530125 DOI: 10.1084/Jem.20121416  0.824
2012 Nayak D, Zinselmeyer BH, Corps KN, McGavern DB. In vivo dynamics of innate immune sentinels in the CNS. Intravital. 1: 95-106. PMID 24078900 DOI: 10.4161/intv.22823  0.819
2012 Oldstone MB, Edelmann KH, McGavern DB, Cruite JT, Welch MJ. Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes. Plos Pathogens. 8: e1003044. PMID 23209415 DOI: 10.1371/Journal.Ppat.1003044  0.573
2012 Herz J, Zinselmeyer BH, McGavern DB. Two-photon imaging of microbial immunity in living tissues. Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 18: 730-41. PMID 22846498 DOI: 10.1017/S1431927612000281  0.822
2012 Garidou L, Heydari S, Gossa S, McGavern DB. Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection. Journal of Virology. 86: 7060-71. PMID 22553324 DOI: 10.1128/Jvi.00164-12  0.822
2011 Fahey LM, Wilson EB, Elsaesser H, Fistonich CD, McGavern DB, Brooks DG. Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells. The Journal of Experimental Medicine. 208: 987-99. PMID 21536743 DOI: 10.1084/Jem.20101773  0.624
2011 McGavern DB, Kang SS. Illuminating viral infections in the nervous system. Nature Reviews. Immunology. 11: 318-29. PMID 21508982 DOI: 10.1038/Nri2971  0.685
2011 Kang SS, Herz J, Kim JV, Nayak D, Stewart-Hutchinson P, Dustin ML, McGavern DB. Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection. The Journal of Experimental Medicine. 208: 747-59. PMID 21464219 DOI: 10.1084/Jem.20101295  0.831
2011 Combs CA, Smirnov A, Chess D, McGavern DB, Schroeder JL, Riley J, Kang SS, Lugar-Hammer M, Gandjbakhche A, Knutson JR, Balaban RS. Optimizing multiphoton fluorescence microscopy light collection from living tissue by noncontact total emission detection (epiTED). Journal of Microscopy. 241: 153-61. PMID 21118209 DOI: 10.1111/J.1365-2818.2010.03411.X  0.537
2010 Kang SS, McGavern DB. Microbial induction of vascular pathology in the CNS. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 5: 370-86. PMID 20401700 DOI: 10.1007/S11481-010-9208-9  0.631
2010 McGavern DB. A little 'help' from IL-21 during persistent viral infection. Journal of Molecular Cell Biology. 2: 8-10. PMID 19797314 DOI: 10.1093/Jmcb/Mjp021  0.468
2009 Truong P, Heydari S, Garidou L, McGavern DB. Persistent viral infection elevates central nervous system MHC class I through chronic production of interferons. Journal of Immunology (Baltimore, Md. : 1950). 183: 3895-905. PMID 19717517 DOI: 10.4049/Jimmunol.0803085  0.812
2009 Garidou L, Heydari S, Truong P, Brooks DG, McGavern DB. Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection. Journal of Virology. 83: 8905-15. PMID 19553326 DOI: 10.1128/Jvi.00027-09  0.826
2009 Kang SS, McGavern DB. Inflammation on the mind: visualizing immunity in the central nervous system. Current Topics in Microbiology and Immunology. 334: 227-63. PMID 19521688 DOI: 10.1007/978-3-540-93864-4_10  0.665
2009 Emonet SF, Garidou L, McGavern DB, de la Torre JC. Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest. Proceedings of the National Academy of Sciences of the United States of America. 106: 3473-8. PMID 19208813 DOI: 10.1073/Pnas.0900088106  0.748
2009 Marsolais D, Hahm B, Walsh KB, Edelmann KH, McGavern D, Hatta Y, Kawaoka Y, Rosen H, Oldstone MB. A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection. Proceedings of the National Academy of Sciences of the United States of America. 106: 1560-5. PMID 19164548 DOI: 10.1073/Pnas.0812689106  0.64
2009 Kim JV, Kang SS, Dustin ML, McGavern DB. Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature. 457: 191-5. PMID 19011611 DOI: 10.1038/Nature07591  0.728
2008 Trifilo MJ, Sanchez-Alavez M, Solforosi L, Bernard-Trifilo J, Kunz S, McGavern D, Oldstone MB. Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway. Journal of Virology. 82: 9890-9. PMID 18667494 DOI: 10.1128/Jvi.00486-08  0.511
2008 Truong P, McGavern DB. A novel virus carrier state to evaluate immunotherapeutic regimens: regulatory T cells modulate the pathogenicity of antiviral memory cells. Journal of Immunology (Baltimore, Md. : 1950). 181: 1161-9. PMID 18606669 DOI: 10.4049/Jimmunol.181.2.1161  0.85
2008 Kang SS, McGavern DB. Lymphocytic choriomeningitis infection of the central nervous system. Frontiers in Bioscience : a Journal and Virtual Library. 13: 4529-43. PMID 18508527 DOI: 10.2741/3021  0.7
2008 Brooks DG, Lee AM, Elsaesser H, McGavern DB, Oldstone MB. IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. The Journal of Experimental Medicine. 205: 533-41. PMID 18332180 DOI: 10.1084/Jem.20071948  0.687
2007 Lauterbach H, Truong P, McGavern DB. Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification. Virology Journal. 4: 53. PMID 17553158 DOI: 10.1186/1743-422X-4-53  0.844
2006 Brooks DG, Trifilo MJ, Edelmann KH, Teyton L, McGavern DB, Oldstone MB. Interleukin-10 determines viral clearance or persistence in vivo. Nature Medicine. 12: 1301-9. PMID 17041596 DOI: 10.1038/Nm1492  0.705
2006 Kunz S, Rojek JM, Roberts AJ, McGavern DB, Oldstone MB, de la Torre JC. Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus. Journal of Virology. 80: 9082-92. PMID 16940520 DOI: 10.1128/Jvi.00795-06  0.591
2006 Lauterbach H, Zuniga EI, Truong P, Oldstone MB, McGavern DB. Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection. The Journal of Experimental Medicine. 203: 1963-75. PMID 16847068 DOI: 10.1084/Jem.20060039  0.84
2006 Brooks DG, McGavern DB, Oldstone MB. Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection. The Journal of Clinical Investigation. 116: 1675-85. PMID 16710479 DOI: 10.1172/Jci26856  0.715
2006 Tishon A, Lewicki H, Andaya A, McGavern D, Martin L, Oldstone MB. CD4 T cell control primary measles virus infection of the CNS: regulation is dependent on combined activity with either CD8 T cells or with B cells: CD4, CD8 or B cells alone are ineffective. Virology. 347: 234-45. PMID 16529787 DOI: 10.1016/J.Virol.2006.01.050  0.612
2006 McGavern DB. Immunotherapeutic relief from persistent infections and amyloid disorders. Neurology. 66: S59-64. PMID 16432147 DOI: 10.1212/01.Wnl.0000192109.81449.7A  0.404
2005 McGavern DB. The role of bystander T cells in CNS pathology and pathogen clearance. Critical Reviews in Immunology. 25: 289-303. PMID 16167882 DOI: 10.1615/Critrevimmunol.V25.I4.30  0.454
2005 Brooks DG, Teyton L, Oldstone MB, McGavern DB. Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection. Journal of Virology. 79: 10514-27. PMID 16051844 DOI: 10.1128/Jvi.79.16.10514-10527.2005  0.721
2004 Zuniga EI, McGavern DB, Pruneda-Paz JL, Teng C, Oldstone MB. Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection. Nature Immunology. 5: 1227-34. PMID 15531885 DOI: 10.1038/Ni1136  0.561
2004 Christen U, Edelmann KH, McGavern DB, Wolfe T, Coon B, Teague MK, Miller SD, Oldstone MB, von Herrath MG. A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes. The Journal of Clinical Investigation. 114: 1290-8. PMID 15520861 DOI: 10.1172/Jci22557  0.568
2004 McGavern DB, Truong P. Rebuilding an immune-mediated central nervous system disease: weighing the pathogenicity of antigen-specific versus bystander T cells. Journal of Immunology (Baltimore, Md. : 1950). 173: 4779-90. PMID 15470017 DOI: 10.4049/Jimmunol.173.8.4779  0.845
2004 Homann D, McGavern DB, Oldstone MB. Visualizing the viral burden: phenotypic and functional alterations of T cells and APCs during persistent infection. Journal of Immunology (Baltimore, Md. : 1950). 172: 6239-50. PMID 15128812 DOI: 10.4049/Jimmunol.172.10.6239  0.653
2004 Sevilla N, McGavern DB, Teng C, Kunz S, Oldstone MB. Viral targeting of hematopoietic progenitors and inhibition of DC maturation as a dual strategy for immune subversion. The Journal of Clinical Investigation. 113: 737-45. PMID 14991072 DOI: 10.1172/Jci20243  0.603
2004 Solforosi L, Criado JR, McGavern DB, Wirz S, Sánchez-Alavez M, Sugama S, DeGiorgio LA, Volpe BT, Wiseman E, Abalos G, Masliah E, Gilden D, Oldstone MB, Conti B, Williamson RA. Cross-linking cellular prion protein triggers neuronal apoptosis in vivo. Science (New York, N.Y.). 303: 1514-6. PMID 14752167 DOI: 10.1126/Science.1094273  0.463
2003 Christen U, McGavern DB, Luster AD, von Herrath MG, Oldstone MB. Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease. Journal of Immunology (Baltimore, Md. : 1950). 171: 6838-45. PMID 14662890 DOI: 10.4049/Jimmunol.171.12.6838  0.594
2003 Stratmann T, Martin-Orozco N, Mallet-Designe V, Poirot L, McGavern D, Losyev G, Dobbs CM, Oldstone MB, Yoshida K, Kikutani H, Mathis D, Benoist C, Haskins K, Teyton L. Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity. The Journal of Clinical Investigation. 112: 902-14. PMID 12975475 DOI: 10.1172/Jci18337  0.56
2003 Zoecklein LJ, Pavelko KD, Gamez J, Papke L, McGavern DB, Ure DR, Njenga MK, Johnson AJ, Nakane S, Rodriguez M. Direct comparison of demyelinating disease induced by the Daniel's strain and BeAn strain of Theiler's murine encephalomyelitis virus. Brain Pathology (Zurich, Switzerland). 13: 291-308. PMID 12946019 DOI: 10.1111/J.1750-3639.2003.Tb00029.X  0.54
2003 Sevilla N, Kunz S, McGavern D, Oldstone MB. Infection of dendritic cells by lymphocytic choriomeningitis virus. Current Topics in Microbiology and Immunology. 276: 125-44. PMID 12797446 DOI: 10.1007/978-3-662-06508-2_6  0.612
2002 McGavern DB, Homann D, Oldstone MB. T cells in the central nervous system: the delicate balance between viral clearance and disease. The Journal of Infectious Diseases. 186: S145-51. PMID 12424690 DOI: 10.1086/344264  0.634
2002 McGavern DB, Christen U, Oldstone MB. Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo. Nature Immunology. 3: 918-25. PMID 12352968 DOI: 10.1038/Ni843  0.611
2002 Lucchinetti CF, Mandler RN, McGavern D, Bruck W, Gleich G, Ransohoff RM, Trebst C, Weinshenker B, Wingerchuk D, Parisi JE, Lassmann H. A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica. Brain : a Journal of Neurology. 125: 1450-61. PMID 12076996 DOI: 10.1093/Brain/Awf151  0.309
2002 Murray PD, McGavern DB, Pease LR, Rodriguez M. Cellular sources and targets of IFN-gamma-mediated protection against viral demyelination and neurological deficits. European Journal of Immunology. 32: 606-15. PMID 11857334 DOI: 10.1002/1521-4141(200203)32:3<606::Aid-Immu606>3.0.Co;2-D  0.562
2001 Kunz S, Sevilla N, McGavern DB, Campbell KP, Oldstone MB. Molecular analysis of the interaction of LCMV with its cellular receptor [alpha]-dystroglycan. The Journal of Cell Biology. 155: 301-10. PMID 11604425 DOI: 10.1083/Jcb.200104103  0.477
2001 Murray PD, McGavern DB, Sathornsumetee S, Rodriguez M. Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis. Brain : a Journal of Neurology. 124: 1403-16. PMID 11408335 DOI: 10.1093/Brain/124.7.1403  0.552
2000 Sathornsumetee S, McGavern DB, Ure DR, Rodriguez M. Quantitative ultrastructural analysis of a single spinal cord demyelinated lesion predicts total lesion load, axonal loss, and neurological dysfunction in a murine model of multiple sclerosis. The American Journal of Pathology. 157: 1365-76. PMID 11021839 DOI: 10.1016/S0002-9440(10)64650-0  0.436
2000 Rodriguez M, Roos RP, McGavern D, Zoecklein L, Pavelko K, Sang H, Lin X. The CD4-mediated immune response is critical in determining the outcome of infection using Theiler's viruses with VP1 capsid protein point mutations. Virology. 275: 9-19. PMID 11017783 DOI: 10.1006/Viro.2000.0493  0.554
2000 McGavern DB, Zoecklein L, Sathornsumetee S, Rodriguez M. Assessment of hindlimb gait as a powerful indicator of axonal loss in a murine model of progressive CNS demyelination. Brain Research. 877: 396-400. PMID 10986359 DOI: 10.1016/S0006-8993(00)02710-4  0.43
2000 Pavelko KD, Drescher KM, McGavern DB, David CS, Rodriguez M. HLA-DQ polymorphism influences progression of demyelination and neurologic deficits in a viral model of multiple sclerosis. Molecular and Cellular Neurosciences. 15: 495-509. PMID 10860577 DOI: 10.1006/Mcne.2000.0843  0.448
2000 McGavern DB, Murray PD, Rivera-Quiñones C, Schmelzer JD, Low PA, Rodriguez M. Axonal loss results in spinal cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosis. Brain : a Journal of Neurology. 123: 519-31. PMID 10686175 DOI: 10.1093/Brain/123.3.519  0.435
1999 McGavern DB, Murray PD, Rodriguez M. Quantitation of spinal cord demyelination, remyelination, atrophy, and axonal loss in a model of progressive neurologic injury. Journal of Neuroscience Research. 58: 492-504. PMID 10533042 DOI: 10.1002/(Sici)1097-4547(19991115)58:4<492::Aid-Jnr3>3.0.Co;2-P  0.438
1999 McGavern DB, Zoecklein L, Drescher KM, Rodriguez M. Quantitative assessment of neurologic deficits in a chronic progressive murine model of CNS demyelination. Experimental Neurology. 158: 171-81. PMID 10448429 DOI: 10.1006/Exnr.1999.7082  0.478
1999 Njenga MK, Murray PD, McGavern D, Lin X, Drescher KM, Rodriguez M. Absence of spontaneous central nervous system remyelination in class II-deficient mice infected with Theiler's virus. Journal of Neuropathology and Experimental Neurology. 58: 78-91. PMID 10068316 DOI: 10.1097/00005072-199901000-00009  0.502
1998 Rivera-Quiñones C, McGavern D, Schmelzer JD, Hunter SF, Low PA, Rodriguez M. Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis. Nature Medicine. 4: 187-193. PMID 9461192 DOI: 10.1038/Nm0298-187  0.483
1998 Murray PD, McGavern DB, Lin X, Njenga MK, Leibowitz J, Pease LR, Rodriguez M. Perforin-Dependent Neurologic Injury in a Viral Model of Multiple Sclerosis The Journal of Neuroscience. 18: 7306-7314. DOI: 10.1523/Jneurosci.18-18-07306.1998  0.599
1998 McGavern D, Rodriguez M. A novel method for the quantification of spinal cord damage in a murine viral model of multiple sclerosis Journal of Neuroimmunology. 90: 58. DOI: 10.1016/S0165-5728(98)91528-4  0.341
1997 Horwitz MS, Evans CF, McGavern DB, Rodriguez M, Oldstone MB. Primary demyelination in transgenic mice expressing interferon-gamma. Nature Medicine. 3: 1037-41. PMID 9288735 DOI: 10.1038/Nm0997-1037  0.625
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