Norbert Arnold - Publications

Affiliations: 
Ludwig-Maximilians-Universität München, München, Bayern, Germany 

150 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Dumont M, Weber-Lassalle N, Joly-Beauparlant C, Ernst C, Droit A, Feng BJ, Dubois S, Collin-Deschesnes AC, Soucy P, Vallée M, Fournier F, Lemaçon A, Adank MA, Allen J, Altmüller J, ... Arnold N, et al. Uncovering the Contribution of Moderate-Penetrance Susceptibility Genes to Breast Cancer by Whole-Exome Sequencing and Targeted Enrichment Sequencing of Candidate Genes in Women of European Ancestry. Cancers. 14. PMID 35884425 DOI: 10.3390/cancers14143363  0.303
2022 Rolfes M, Borde J, Möllenhoff K, Kayali M, Ernst C, Gehrig A, Sutter C, Ramser J, Niederacher D, Horváth J, Arnold N, Meindl A, Auber B, Rump A, Wang-Gohrke S, et al. Prevalence of Cancer Predisposition Germline Variants in Male Breast Cancer Patients: Results of the German Consortium for Hereditary Breast and Ovarian Cancer. Cancers. 14. PMID 35805063 DOI: 10.3390/cancers14133292  0.311
2021 Lakeman IMM, van den Broek AJ, Vos JAM, Barnes DR, Adlard J, Andrulis IL, Arason A, Arnold N, Arun BK, Balmaña J, Barrowdale D, Benitez J, Borg A, Caldés T, Caligo MA, et al. The predictive ability of the 313 variant-based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 34113011 DOI: 10.1038/s41436-021-01198-7  0.308
2021 Coignard J, Lush M, Beesley J, O'Mara TA, Dennis J, Tyrer JP, Barnes DR, McGuffog L, Leslie G, Bolla MK, Adank MA, Agata S, Ahearn T, Aittomäki K, Andrulis IL, ... ... Arnold N, et al. Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers. Nature Communications. 12: 2986. PMID 33990587 DOI: 10.1038/s41467-021-23162-4  0.309
2021 Coignard J, Lush M, Beesley J, O'Mara TA, Dennis J, Tyrer JP, Barnes DR, McGuffog L, Leslie G, Bolla MK, Adank MA, Agata S, Ahearn T, Aittomäki K, Andrulis IL, ... ... Arnold N, et al. A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers. Nature Communications. 12: 1078. PMID 33597508 DOI: 10.1038/s41467-020-20496-3  0.3
2021 Dorling L, Carvalho S, Allen J, González-Neira A, Luccarini C, Wahlström C, Pooley KA, Parsons MT, Fortuno C, Wang Q, Bolla MK, Dennis J, Keeman R, Alonso MR, ... ... Arnold N, et al. Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women. The New England Journal of Medicine. PMID 33471991 DOI: 10.1056/NEJMoa1913948  0.308
2020 Borde J, Ernst C, Wappenschmidt B, Niederacher D, Weber-Lassalle K, Schmidt G, Hauke J, Quante AS, Weber-Lassalle N, Horváth J, Pohl-Rescigno E, Arnold N, Rump A, Gehrig A, Hentschel J, et al. Performance of breast cancer polygenic risk scores in 760 female CHEK2 germline mutation carriers. Journal of the National Cancer Institute. PMID 33372680 DOI: 10.1093/jnci/djaa203  0.316
2020 Barnes DR, Rookus MA, McGuffog L, Leslie G, Mooij TM, Dennis J, Mavaddat N, Adlard J, Ahmed M, Aittomäki K, Andrieu N, Andrulis IL, Arnold N, Arun BK, Azzollini J, et al. Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 32665703 DOI: 10.1038/S41436-020-0862-X  0.421
2020 Liu J, Prager-van der Smissen WJC, Collée JM, Bolla MK, Wang Q, Michailidou K, Dennis J, Ahearn TU, Aittomäki K, Ambrosone CB, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Arnold N, et al. Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk. Scientific Reports. 10: 9688. PMID 32546843 DOI: 10.1038/S41598-020-65665-Y  0.45
2020 Wappenschmidt B, Hauke J, Faust U, Niederacher D, Wiesmüller L, Schmidt G, Groß E, Gehrig A, Sutter C, Ramser J, Rump A, Arnold N, Meindl A. Criteria of the German Consortium for Hereditary Breast and Ovarian Cancer for the Classification of Germline Sequence Variants in Risk Genes for Hereditary Breast and Ovarian Cancer. Geburtshilfe Und Frauenheilkunde. 80: 410-429. PMID 32322110 DOI: 10.1055/A-1110-0909  0.372
2019 Mijnes J, Tiedemann J, Eschenbruch J, Gasthaus J, Bringezu S, Bauerschlag D, Maass N, Arnold N, Weimer J, Anzeneder T, Fasching PA, Rübner M, Bruno B, Heindrichs U, Freres J, et al. SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection. Oncotarget. 10: 6494-6508. PMID 31741713 DOI: 10.18632/Oncotarget.27303  0.394
2019 Patel VL, Busch EL, Friebel TM, Cronin A, Leslie G, McGuffog L, Adlard J, Agata S, Agnarsson BA, Ahmed M, Aittomäki K, Alducci E, Andrulis IL, Arason A, Arnold N, et al. Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness. Cancer Research. PMID 31723001 DOI: 10.1158/0008-5472.Can-19-1840  0.342
2019 Figlioli G, Bogliolo M, Catucci I, Caleca L, Lasheras SV, Pujol R, Kiiski JI, Muranen TA, Barnes DR, Dennis J, Michailidou K, Bolla MK, Leslie G, Aalfs CM, ... ... Arnold N, et al. The :p.Arg658* truncating variant is associated with risk of triple-negative breast cancer. Npj Breast Cancer. 5: 38. PMID 31700994 DOI: 10.1038/s41523-019-0127-5  0.336
2019 Sepahi I, Faust U, Sturm M, Bosse K, Kehrer M, Heinrich T, Grundman-Hauser K, Bauer P, Ossowski S, Susak H, Varon R, Schröck E, Niederacher D, Auber B, Sutter C, ... Arnold N, et al. Investigating the effects of additional truncating variants in DNA-repair genes on breast cancer risk in BRCA1-positive women. Bmc Cancer. 19: 787. PMID 31395037 DOI: 10.1186/S12885-019-5946-0  0.428
2019 Qian F, Rookus MA, Leslie G, Risch HA, Greene MH, Aalfs CM, Adank MA, Adlard J, Agnarsson BA, Ahmed M, Aittomäki K, Andrulis IL, Arnold N, Arun BK, Ausems MGEM, et al. Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers. British Journal of Cancer. PMID 31213659 DOI: 10.1038/S41416-019-0492-8  0.37
2019 Parsons MT, Tudini E, Li H, Hahnen E, Wappenschmidt B, Feliubadaló L, Aalfs CM, Agata S, Aittomäki K, Alducci E, Alonso-Cerezo MC, Arnold N, Auber B, Austin R, Azzollini J, et al. Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification. Human Mutation. PMID 31131967 DOI: 10.1002/Humu.23818  0.357
2019 Engel C, Fischer C, Zachariae S, Bucksch K, Rhiem K, Giesecke J, Herold N, Wappenschmidt B, Hübbel V, Maringa M, Reichstein-Gnielinski S, Hahnen E, Bartram CR, Dikow N, Schott S, ... ... Arnold N, et al. Breast cancer risk in BRCA1/2 mutation carriers and non-carriers under prospective intensified surveillance. International Journal of Cancer. PMID 31081934 DOI: 10.1002/Ijc.32396  0.412
2019 Weber-Lassalle N, Borde J, Weber-Lassalle K, Horváth J, Niederacher D, Arnold N, Kaulfuß S, Ernst C, Paul VG, Honisch E, Klaschik K, Volk AE, Kubisch C, Rapp S, Lichey N, et al. Germline loss-of-function variants in the BARD1 gene are associated with early-onset familial breast cancer but not ovarian cancer. Breast Cancer Research : Bcr. 21: 55. PMID 31036035 DOI: 10.1186/S13058-019-1137-9  0.443
2019 Klaschik K, Hauke J, Neidhardt G, Tränkle C, Surowy HM, Heilmann-Heimbach S, Rappl G, Mangold E, Arnold N, Niederacher D, Sutter C, Burwinkel B, Engel C, Wappenschmidt B, Meindl A, et al. The GPRC5A frameshift variant c.183del is not associated with increased breast cancer risk in BRCA1 mutation carriers. International Journal of Cancer. 144: 1761-1763. PMID 30474284 DOI: 10.1002/Ijc.32016  0.433
2018 Forster M, Mark A, Egberts F, Rosati E, Rodriguez E, Stanulla M, Bauerschlag D, Schem C, Maass N, Amallraja A, Murphy KK, Prouse BR, Sulaiman RA, Young BM, Mathiak M, ... ... Arnold N, et al. RNA based individualized drug selection in breast cancer patients without patient-matched normal tissue. Oncotarget. 9: 32362-32372. PMID 30190792 DOI: 10.18632/Oncotarget.25981  0.309
2018 Hedemann N, Rogmans C, Sebens S, Wesch D, Reichert M, Schmidt-Arras D, Oberg HH, Pecks U, van Mackelenbergh M, Weimer J, Arnold N, Maass N, Bauerschlag DO. ADAM17 inhibition enhances platinum efficiency in ovarian cancer. Oncotarget. 9: 16043-16058. PMID 29662625 DOI: 10.18632/Oncotarget.24682  0.342
2018 Hauke J, Horvath J, Groß E, Gehrig A, Honisch E, Hackmann K, Schmidt G, Arnold N, Faust U, Sutter C, Hentschel J, Wang-Gohrke S, Smogavec M, Weber BHF, Weber-Lassalle N, et al. Gene panel testing of 5589 BRCA1/2-negative index patients with breast cancer in a routine diagnostic setting: results of the German Consortium for Hereditary Breast and Ovarian Cancer. Cancer Medicine. PMID 29522266 DOI: 10.1002/Cam4.1376  0.435
2018 Engel C, Rhiem K, Hahnen E, Loibl S, Weber KE, Seiler S, Zachariae S, Hauke J, Wappenschmidt B, Waha A, Blümcke B, Kiechle M, Meindl A, Niederacher D, Bartram CR, ... ... Arnold N, et al. Prevalence of pathogenic BRCA1/2 germline mutations among 802 women with unilateral triple-negative breast cancer without family cancer history. Bmc Cancer. 18: 265. PMID 29514593 DOI: 10.1186/S12885-018-4029-Y  0.43
2018 Weber-Lassalle N, Hauke J, Ramser J, Richters L, Groß E, Blümcke B, Gehrig A, Kahlert AK, Müller CR, Hackmann K, Honisch E, Weber-Lassalle K, Niederacher D, Borde J, Thiele H, ... ... Arnold N, et al. BRIP1 loss-of-function mutations confer high risk for familial ovarian cancer, but not familial breast cancer. Breast Cancer Research : Bcr. 20: 7. PMID 29368626 DOI: 10.1186/S13058-018-0935-9  0.447
2018 Kast K, Wimberger P, Arnold N. Changes in classification of genetic variants in BRCA1 and BRCA2. Archives of Gynecology and Obstetrics. PMID 29302806 DOI: 10.1007/S00404-017-4631-2  0.388
2018 Stuebs F, Heidemann S, Caliebe A, Mundhenke C, Arnold N. CDH1 mutation screen in a BRCA1/2-negative familial breast-/ovarian cancer cohort. Archives of Gynecology and Obstetrics. 297: 147-152. PMID 28993866 DOI: 10.1007/S00404-017-4551-1  0.409
2017 Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindström S, Hui S, Lemaçon A, Soucy P, Dennis J, Jiang X, Rostamianfar A, Finucane H, Bolla MK, McGuffog L, ... ... Arnold N, et al. Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Nature Genetics. PMID 29058716 DOI: 10.1038/Ng.3785  0.445
2017 Moghadasi S, Meeks HD, Vreeswijk MP, Janssen LA, Borg Å, Ehrencrona H, Paulsson-Karlsson Y, Wappenschmidt B, Engel C, Gehrig A, Arnold N, Hansen TVO, Thomassen M, Jensen UB, Kruse TA, et al. The BRCA1 c. 5096G>A p.Arg1699Gln (R1699Q) intermediate risk variant: breast and ovarian cancer risk estimation and recommendations for clinical management from the ENIGMA consortium. Journal of Medical Genetics. PMID 28490613 DOI: 10.1136/Jmedgenet-2017-104560  0.419
2017 Lecarpentier J, Silvestri V, Kuchenbaecker KB, Barrowdale D, Dennis J, McGuffog L, Soucy P, Leslie G, Rizzolo P, Navazio AS, Valentini V, Zelli V, Lee A, Amin Al Olama A, Tyrer JP, ... ... Arnold N, et al. Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2016694935. PMID 28448241 DOI: 10.1200/Jco.2016.69.4935  0.42
2017 Meisel C, Sadowski CE, Kohlstedt D, Keller K, Stäritz F, Grübling N, Becker K, Mackenroth L, Rump A, Schröck E, Arnold N, Wimberger P, Kast K. Spectrum of genetic variants of BRCA1 and BRCA2 in a German single center study. Archives of Gynecology and Obstetrics. PMID 28324225 DOI: 10.1007/S00404-017-4330-Z  0.327
2017 Pohl E, Hauke J, Horvath J, Dworniczak B, Gehrig A, Niederacher D, Arnold N, Sutter C, Smogavec M, Just W, Weber BHF, Hentschel J, Faust U, Hackmann K, Schmidt G, et al. NGS-based multi-gene panel analysis in BRCA1/2-negative breast and ovarian cancer families. Journal of Clinical Oncology. 35: 1526-1526. DOI: 10.1200/Jco.2017.35.15_Suppl.1526  0.451
2017 Pohl E, Richters L, Hauke J, Ernst C, Kröber S, Niederacher D, Arnold N, Ramser J, Groß E, Gehrig A, Schmidt G, Dutrannoy V, Kast K, Hahnen E, Schmutzler R. Abstract P3-09-04: BeyondCHEK2in breast cancer: Search for additional moderately penetrant risk gene variants by analyzing the oligogenic disease course inCHEK2mutation carriers Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-P3-09-04  0.413
2016 Rebbeck TR, Friebel TM, Mitra N, Wan F, Chen S, Andrulis IL, Apostolou P, Arnold N, Arun BK, Barrowdale D, Benitez J, Berger R, Berthet P, Borg A, Buys SS, et al. Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women. Breast Cancer Research : Bcr. 18: 112. PMID 27836010 DOI: 10.1186/S13058-016-0768-3  0.324
2016 Hamdi Y, Soucy P, Kuchenbaeker KB, Pastinen T, Droit A, Lemaçon A, Adlard J, Aittomäki K, Andrulis IL, Arason A, Arnold N, Arun BK, Azzollini J, Bane A, Barjhoux L, et al. Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3. Breast Cancer Research and Treatment. PMID 27796716 DOI: 10.1007/S10549-016-4018-2  0.47
2016 Andradas C, Blasco-Benito S, Castillo-Lluva S, Dillenburg-Pilla P, Diez-Alarcia R, Juanes-García A, García-Taboada E, Hernando-Llorente R, Soriano J, Hamann S, Wenners A, Alkatout I, Klapper W, Rocken C, Bauer M, ... Arnold N, et al. Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer. Oncotarget. PMID 27340777 DOI: 10.18632/Oncotarget.10206  0.401
2016 de la Hoya M, Soukarieh O, López-Perolio I, Vega A, Walker LC, van Ierland Y, Baralle D, Santamariña M, Lattimore V, Wijnen J, Whiley P, Blanco A, Raponi M, Hauke J, Wappenschmidt B, ... ... Arnold N, et al. Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms. Human Molecular Genetics. PMID 27008870 DOI: 10.1093/Hmg/Ddw094  0.328
2016 Kast K, Rhiem K, Wappenschmidt B, Hahnen E, Hauke J, Bluemcke B, Zarghooni V, Herold N, Ditsch N, Kiechle M, Braun M, Fischer C, Dikow N, Schott S, Rahner N, ... ... Arnold N, et al. Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer. Journal of Medical Genetics. PMID 26928436 DOI: 10.1136/Jmedgenet-2015-103672  0.427
2016 Dunning AM, Michailidou K, Kuchenbaecker KB, Thompson D, French JD, Beesley J, Healey CS, Kar S, Pooley KA, Lopez-Knowles E, Dicks E, Barrowdale D, Sinnott-Armstrong NA, Sallari RC, Hillman KM, ... ... Arnold N, et al. Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nature Genetics. PMID 26928228 DOI: 10.1038/Ng.3521  0.364
2016 Silvestri V, Barrowdale D, Mulligan AM, Neuhausen SL, Fox S, Karlan BY, Mitchell G, James P, Thull DL, Zorn KK, Carter NJ, Nathanson KL, Domchek SM, Rebbeck TR, Ramus SJ, ... ... Arnold N, et al. Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Research : Bcr. 18: 15. PMID 26857456 DOI: 10.1186/S13058-016-0671-Y  0.427
2016 Huang X, Weimer J, von Wurmb-Schwark N, Fredrik R, Arnold N, Schem C. Alteration of STR profiles in ovarian carcinoma cells during primary culture. Archives of Gynecology and Obstetrics. PMID 26825732 DOI: 10.1007/S00404-016-4018-9  0.313
2016 Rhiem K, Engel C, Engel J, Niederacher D, Sutter C, Varon-Mateeva R, Steinemann D, Arnold N, Dworniczak B, Wang-Gohrke S, Gehrig A, Wappenschmidt B, Meindl A, Schmutzler RK. BRCA1/2 mutation prevalence in triple-negative breast cancer patients without family history of breast and ovarian cancer. Journal of Clinical Oncology. 34: 1090-1090. DOI: 10.1200/Jco.2016.34.15_Suppl.1090  0.434
2015 Darabi H, McCue K, Beesley J, Michailidou K, Nord S, Kar S, Humphreys K, Thompson D, Ghoussaini M, Bolla MK, Dennis J, Wang Q, Canisius S, Scott CG, Apicella C, ... ... Arnold N, et al. Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression. American Journal of Human Genetics. 97: 22-34. PMID 26073781 DOI: 10.1016/J.Ajhg.2015.05.002  0.404
2015 Hollestelle A, van der Baan FH, Berchuck A, Johnatty SE, Aben KK, Agnarsson BA, Aittomäki K, Alducci E, Andrulis IL, Anton-Culver H, Antonenkova NN, Antoniou AC, Apicella C, Arndt V, ... Arnold N, et al. No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer. Gynecologic Oncology. PMID 25940428 DOI: 10.1016/J.Ygyno.2015.04.034  0.419
2015 Blein S, Bardel C, Danjean V, McGuffog L, Healey S, Barrowdale D, Lee A, Dennis J, Kuchenbaecker KB, Soucy P, Terry MB, Chung WK, Goldgar DE, Buys SS, ... ... Arnold N, et al. An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers. Breast Cancer Research : Bcr. 17: 61. PMID 25925750 DOI: 10.1186/S13058-015-0567-2  0.405
2015 Pérez-Gómez E, Andradas C, Blasco-Benito S, Caffarel MM, García-Taboada E, Villa-Morales M, Moreno E, Hamann S, Martín-Villar E, Flores JM, Wenners A, Alkatout I, Klapper W, Röcken C, Bronsert P, ... ... Arnold N, et al. Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer. Journal of the National Cancer Institute. 107: djv077. PMID 25855725 DOI: 10.1093/Jnci/Djv077  0.371
2015 Rebbeck TR, Mitra N, Wan F, Sinilnikova OM, Healey S, McGuffog L, Mazoyer S, Chenevix-Trench G, Easton DF, Antoniou AC, Nathanson KL, Laitman Y, Kushnir A, Paluch-Shimon S, ... ... Arnold N, et al. Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. Jama. 313: 1347-61. PMID 25849179 DOI: 10.1001/Jama.2014.5985  0.433
2015 Blanco I, Kuchenbaecker K, Cuadras D, Wang X, Barrowdale D, de Garibay GR, Librado P, Sánchez-Gracia A, Rozas J, Bonifaci N, McGuffog L, Pankratz VS, Islam A, Mateo F, Berenguer A, ... ... Arnold N, et al. Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers. Plos One. 10: e0120020. PMID 25830658 DOI: 10.1371/Journal.Pone.0120020  0.443
2015 Roessler J, Ammerpohl O, Gutwein J, Steinemann D, Schlegelberger B, Weyer V, Sariyar M, Geffers R, Arnold N, Schmutzler R, Bartram CR, Heinrich T, Abbas M, Antonopoulos W, Schipper E, et al. The CpG island methylator phenotype in breast cancer is associated with the lobular subtype. Epigenomics. 7: 187-99. PMID 25347269 DOI: 10.2217/Epi.14.74  0.364
2015 Peterlongo P, Chang-Claude J, Moysich KB, Rudolph A, Schmutzler RK, Simard J, Soucy P, Eeles RA, Easton DF, Hamann U, Wilkening S, Chen B, Rookus MA, Schmidt MK, van der Baan FH, ... ... Arnold N, et al. Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 24: 308-16. PMID 25336561 DOI: 10.1158/1055-9965.Epi-14-0532  0.441
2014 Kuchenbaecker KB, Neuhausen SL, Robson M, Barrowdale D, McGuffog L, Mulligan AM, Andrulis IL, Spurdle AB, Schmidt MK, Schmutzler RK, Engel C, Wappenschmidt B, Nevanlinna H, Thomassen M, Southey M, ... ... Arnold N, et al. Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research : Bcr. 16: 3416. PMID 25919761 DOI: 10.1186/S13058-014-0492-9  0.403
2014 Spurdle AB, Couch FJ, Parsons MT, McGuffog L, Barrowdale D, Bolla MK, Wang Q, Healey S, Schmutzler R, Wappenschmidt B, Rhiem K, Hahnen E, Engel C, Meindl A, Ditsch N, ... Arnold N, et al. Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia. Breast Cancer Research : Bcr. 16: 3419. PMID 25857409 DOI: 10.1186/S13058-014-0474-Y  0.379
2014 Kast K, Schmutzler RK, Rhiem K, Kiechle M, Fischer C, Niederacher D, Arnold N, Grimm T, Speiser D, Schlegelberger B, Varga D, Horvath J, Beer M, Briest S, Meindl A, et al. Validation of the Manchester scoring system for predicting BRCA1/2 mutations in 9,390 families suspected of having hereditary breast and ovarian cancer. International Journal of Cancer. Journal International Du Cancer. 135: 2352-61. PMID 24700448 DOI: 10.1002/Ijc.28875  0.403
2014 Osorio A, Milne RL, Kuchenbaecker K, Vaclová T, Pita G, Alonso R, Peterlongo P, Blanco I, de la Hoya M, Duran M, Díez O, Ramón Y Cajal T, Konstantopoulou I, Martínez-Bouzas C, Andrés Conejero R, ... ... Arnold N, et al. DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers. Plos Genetics. 10: e1004256. PMID 24698998 DOI: 10.1371/Journal.Pgen.1004256  0.436
2014 Wang L, Wenners A, Hilpert F, Fredrik R, Micci F, Onkes W, Caliebe A, Maass N, Weimer J, Arnold N. Frequent translocations of 11q13.2 and 19p13.2 in ovarian cancer Genes Chromosomes and Cancer. 53: 447-453. PMID 24615723 DOI: 10.1002/Gcc.22152  0.382
2013 Couch FJ, Wang X, McGuffog L, Lee A, Olswold C, Kuchenbaecker KB, Soucy P, Fredericksen Z, Barrowdale D, Dennis J, Gaudet MM, Dicks E, Kosel M, Healey S, Sinilnikova OM, ... ... Arnold N, et al. Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. Plos Genetics. 9: e1003212. PMID 23544013 DOI: 10.1371/Journal.Pgen.1003212  0.441
2013 Gaudet MM, Kuchenbaecker KB, Vijai J, Klein RJ, Kirchhoff T, McGuffog L, Barrowdale D, Dunning AM, Lee A, Dennis J, Healey S, Dicks E, Soucy P, Sinilnikova OM, Pankratz VS, ... ... Arnold N, et al. Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. Plos Genetics. 9: e1003173. PMID 23544012 DOI: 10.1371/Journal.Pgen.1003173  0.469
2013 Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP, Edwards SL, Pickett HA, Shen HC, Smart CE, Hillman KM, Mai PL, Lawrenson K, Stutz MD, Lu Y, ... ... Arnold N, et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nature Genetics. 45: 371-84, 384e1-2. PMID 23535731 DOI: 10.1038/Ng.2566  0.403
2013 Onkes W, Fredrik R, Micci F, Schönbeck BJ, Martin-Subero JI, Ullmann R, Hilpert F, Bräutigam K, Janssen O, Maass N, Siebert R, Heim S, Arnold N, Weimer J. Breakpoint characterization of the der(19)t(11;19)(q13;p13) in the ovarian cancer cell line SKOV-3. Genes, Chromosomes & Cancer. 52: 512-22. PMID 23362175 DOI: 10.1002/Gcc.22048  0.335
2013 Volkmann J, Reuning U, Rudelius M, Häfner N, Schuster T, Aaron AB, Weimer J, Hilpert F, Kiechle M, Dürst M, Arnold N, Schmalfeldt B, Meindl A, Ramser J. High expression of crystallin αb represents an independent molecular marker for unfavourable ovarian cancer patient outcome and impairs TRAIL- and cisplatin-induced apoptosis in human ovarian cancer cells International Journal of Cancer. 132: 2820-2832. PMID 23225306 DOI: 10.1002/Ijc.27975  0.355
2013 Salaverria I, Martin-Guerrero I, Burkhardt B, Kreuz M, Zenz T, Oschlies I, Arnold N, Baudis M, Bens S, García-Orad A, Lisfeld J, Schwaenen C, Szczepanowski M, Wessendorf S, Pfreundschuh M, et al. High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas. Genes, Chromosomes & Cancer. 52: 150-5. PMID 23073988 DOI: 10.1002/Gcc.22014  0.307
2012 Wappenschmidt B, Becker AA, Hauke J, Weber U, Engert S, Köhler J, Kast K, Arnold N, Rhiem K, Hahnen E, Meindl A, Schmutzler RK. Analysis of 30 putative BRCA1 splicing mutations in hereditary breast and ovarian cancer families identifies exonic splice site mutations that escape in silico prediction. Plos One. 7: e50800. PMID 23239986 DOI: 10.1371/Journal.Pone.0050800  0.395
2012 Wenners AS, Mehta K, Loibl S, Park H, Mueller B, Arnold N, Hamann S, Weimer J, Ataseven B, Darb-Esfahani S, Schem C, Mundhenke C, Khandan F, Thomssen C, Jonat W, et al. Neutrophil gelatinase-associated lipocalin (NGAL) predicts response to neoadjuvant chemotherapy and clinical outcome in primary human breast cancer. Plos One. 7: e45826. PMID 23056218 DOI: 10.1371/Journal.Pone.0045826  0.329
2012 Lühr I, Friedl A, Overath T, Tholey A, Kunze T, Hilpert F, Sebens S, Arnold N, Rösel F, Oberg HH, Maass N, Mundhenke C, Jonat W, Bauer M. Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals. Cancer Letters. 325: 175-88. PMID 22776560 DOI: 10.1016/J.Canlet.2012.06.014  0.329
2012 Ding YC, McGuffog L, Healey S, Friedman E, Laitman Y, Paluch-Shimon S, Kaufman B, Liljegren A, Lindblom A, Olsson H, Kristoffersson U, Stenmark-Askmalm M, Melin B, Domchek SM, ... ... Arnold N, et al. A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 21: 1362-70. PMID 22729394 DOI: 10.1158/1055-9965.Epi-12-0229  0.446
2012 Jakubowska A, Rozkrut D, Antoniou A, Hamann U, Scott RJ, McGuffog L, Healy S, Sinilnikova OM, Rennert G, Lejbkowicz F, Flugelman A, Andrulis IL, Glendon G, Ozcelik H, ... ... Arnold N, et al. Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study. British Journal of Cancer. 106: 2016-24. PMID 22669161 DOI: 10.1038/Bjc.2012.160  0.448
2012 Heidemann S, Fischer C, Engel C, Fischer B, Harder L, Schlegelberger B, Niederacher D, Goecke TO, Doelken SC, Dikow N, Jonat W, Morlot S, Schmutzler RC, Arnold NK. Double heterozygosity for mutations in BRCA1 and BRCA2 in German breast cancer patients: implications on test strategies and clinical management. Breast Cancer Research and Treatment. 134: 1229-39. PMID 22535016 DOI: 10.1007/s10549-012-2050-4  0.327
2012 Couch FJ, Gaudet MM, Antoniou AC, Ramus SJ, Kuchenbaecker KB, Soucy P, Beesley J, Chen X, Wang X, Kirchhoff T, McGuffog L, Barrowdale D, Lee A, Healey S, Sinilnikova OM, ... ... Arnold N, et al. Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 21: 645-57. PMID 22351618 DOI: 10.1158/1055-9965.Epi-11-0888  0.462
2012 Antoniou AC, Kuchenbaecker KB, Soucy P, Beesley J, Chen X, McGuffog L, Lee A, Barrowdale D, Healey S, Sinilnikova OM, Caligo MA, Loman N, Harbst K, Lindblom A, Arver B, ... ... Arnold N, et al. Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast Cancer Research : Bcr. 14: R33. PMID 22348646 DOI: 10.1186/Bcr3121  0.414
2012 Ramus SJ, Antoniou AC, Kuchenbaecker KB, Soucy P, Beesley J, Chen X, McGuffog L, Sinilnikova OM, Healey S, Barrowdale D, Lee A, Thomassen M, Gerdes AM, Kruse TA, Jensen UB, ... ... Arnold N, et al. Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. Human Mutation. 33: 690-702. PMID 22253144 DOI: 10.1002/Humu.22025  0.406
2012 Mavaddat N, Barrowdale D, Andrulis IL, Domchek SM, Eccles D, Nevanlinna H, Ramus SJ, Spurdle A, Robson M, Sherman M, Mulligan AM, Couch FJ, Engel C, McGuffog L, Healey S, ... ... Arnold N, et al. Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 21: 134-47. PMID 22144499 DOI: 10.1158/1055-9965.Epi-11-0775  0.421
2012 Dick MG, Versmold B, Engel C, Meindl A, Arnold N, Varon-Mateeva R, Sutter C, Niederacher D, Deissler H, Preisler-Adams S, Kast K, Schäfer D, Gadzicki D, Heinritz W, Wappenschmidt B, et al. Association of death receptor 4 variant (683A > C) with ovarian cancer risk in BRCA1 mutation carriers. International Journal of Cancer. 130: 1314-8. PMID 21484799 DOI: 10.1002/Ijc.26134  0.438
2012 Kast K, Arnold N. Gene diagnostics for hereditary tumors Gynakologe. 45: 28-34. DOI: 10.1007/S00129-011-2857-9  0.351
2011 Wenners AS, Mehta K, Loibl S, Park H, Arnold N, Hamann S, Weimer J, Ataseven B, Schem C, Khandan F, Thomssen C, Jonat W, Holzhausen H, Von Minckwitz G, Denkert C, et al. Evaluation of neutrophil gelatinase-associated lipocalin (NGAL) as predictor of response to neoadjuvant chemotherapy (NACT) in primary breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 595. PMID 28021535 DOI: 10.1200/Jco.2011.29.15_Suppl.595  0.359
2011 Maxwell CA, Benítez J, Gómez-Baldó L, Osorio A, Bonifaci N, Fernández-Ramires R, Costes SV, Guinó E, Chen H, Evans GJ, Mohan P, Català I, Petit A, Aguilar H, Villanueva A, ... ... Arnold N, et al. Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. Plos Biology. 9: e1001199. PMID 22110403 DOI: 10.1371/Journal.Pbio.1001199  0.436
2011 Mulligan AM, Couch FJ, Barrowdale D, Domchek SM, Eccles D, Nevanlinna H, Ramus SJ, Robson M, Sherman M, Spurdle AB, Wappenschmidt B, Lee A, McGuffog L, Healey S, Sinilnikova OM, ... ... Arnold N, et al. Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Research : Bcr. 13: R110. PMID 22053997 DOI: 10.1186/Bcr3052  0.451
2011 Focken T, Steinemann D, Skawran B, Hofmann W, Ahrens P, Arnold N, Kroll P, Kreipe H, Schlegelberger B, Gadzicki D. Human BRCA1-associated breast cancer: no increase in numerical chromosomal instability compared to sporadic tumors. Cytogenetic and Genome Research. 135: 84-92. PMID 22024613 DOI: 10.1159/000332005  0.433
2011 Cox DG, Simard J, Sinnett D, Hamdi Y, Soucy P, Ouimet M, Barjhoux L, Verny-Pierre C, McGuffog L, Healey S, Szabo C, Greene MH, Mai PL, Andrulis IL, ... ... Arnold N, et al. Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers. Human Molecular Genetics. 20: 4732-47. PMID 21890493 DOI: 10.1093/Hmg/Ddr388  0.457
2011 Hellebrand H, Sutter C, Honisch E, Gross E, Wappenschmidt B, Schem C, Deissler H, Ditsch N, Gress V, Kiechle M, Bartram CR, Schmutzler RK, Niederacher D, Arnold N, Meindl A. Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer. Human Mutation. 32: E2176-88. PMID 21618343 DOI: 10.1002/Humu.21478  0.41
2011 Antoniou AC, Kartsonaki C, Sinilnikova OM, Soucy P, McGuffog L, Healey S, Lee A, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Cattaneo E, Barile M, Pensotti V, Pasini B, ... ... Arnold N, et al. Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers. Human Molecular Genetics. 20: 3304-21. PMID 21593217 DOI: 10.1093/Hmg/Ddr226  0.446
2011 Ramus SJ, Kartsonaki C, Gayther SA, Pharoah PD, Sinilnikova OM, Beesley J, Chen X, McGuffog L, Healey S, Couch FJ, Wang X, Fredericksen Z, Peterlongo P, Manoukian S, Peissel B, ... ... Arnold N, et al. Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Journal of the National Cancer Institute. 103: 105-16. PMID 21169536 DOI: 10.1093/Jnci/Djq494  0.451
2011 Wang F, Hu Z, Yang R, Tang J, Liu Y, Hemminki K, Sutter C, Wappenschmidt B, Niederacher D, Arnold N, Meindl A, Bartram CR, Schmutzler RK, Burwinkel B, Shen H. A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk. Breast Cancer Research and Treatment. 127: 769-75. PMID 21140207 DOI: 10.1007/S10549-010-1157-8  0.402
2011 Yang R, Dick M, Marme F, Schneeweiss A, Langheinz A, Hemminki K, Sutter C, Bugert P, Wappenschmidt B, Varon R, Schott S, Weber BH, Niederacher D, Arnold N, Meindl A, et al. Genetic variants within miR-126 and miR-335 are not associated with breast cancer risk. Breast Cancer Research and Treatment. 127: 549-54. PMID 21046227 DOI: 10.1007/S10549-010-1244-X  0.305
2011 Bräutigam K, Biernath-Wüpping J, Bauerschlag DO, Kaisenberg CSv, Jonat W, Maass N, Arnold N, Meinhold-Heerlein I. Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines Journal of Cancer Research and Clinical Oncology. 137: 875-886. PMID 20878528 DOI: 10.1007/S00432-010-0952-2  0.322
2010 Antoniou AC, Beesley J, McGuffog L, Sinilnikova OM, Healey S, Neuhausen SL, Ding YC, Rebbeck TR, Weitzel JN, Lynch HT, Isaacs C, Ganz PA, Tomlinson G, Olopade OI, Couch FJ, ... ... Arnold N, et al. Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction. Cancer Research. 70: 9742-54. PMID 21118973 DOI: 10.1158/0008-5472.Can-10-1907  0.441
2010 Gaudet MM, Kirchhoff T, Green T, Vijai J, Korn JM, Guiducci C, Segrè AV, McGee K, McGuffog L, Kartsonaki C, Morrison J, Healey S, Sinilnikova OM, Stoppa-Lyonnet D, Mazoyer S, ... ... Arnold N, et al. Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. Plos Genetics. 6: e1001183. PMID 21060860 DOI: 10.1371/Journal.Pgen.1001183  0.444
2010 Engel C, Versmold B, Wappenschmidt B, Simard J, Easton DF, Peock S, Cook M, Oliver C, Frost D, Mayes R, Evans DG, Eeles R, Paterson J, Brewer C, ... ... Arnold N, et al. Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 19: 2859-68. PMID 20978178 DOI: 10.1158/1055-9965.Epi-10-0517  0.461
2010 Antoniou AC, Wang X, Fredericksen ZS, McGuffog L, Tarrell R, Sinilnikova OM, Healey S, Morrison J, Kartsonaki C, Lesnick T, Ghoussaini M, Barrowdale D, Peock S, Cook M, ... ... Arnold N, et al. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nature Genetics. 42: 885-92. PMID 20852631 DOI: 10.1038/Ng.669  0.439
2010 Micci F, Skotheim RI, Haugom L, Weimer J, Eibak AM, Abeler VM, Trope CG, Arnold N, Lothe RA, Heim S. Array-CGH analysis of microdissected chromosome 19 markers in ovarian carcinoma identifies candidate target genes. Genes, Chromosomes & Cancer. 49: 1046-53. PMID 20725991 DOI: 10.1002/Gcc.20813  0.309
2010 Yang R, Schlehe B, Hemminki K, Sutter C, Bugert P, Wappenschmidt B, Volkmann J, Varon R, Weber BHF, Niederacher D, Arnold N, Meindl A, Bartram CR, Schmutzler RK, Burwinkel B. A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk Breast Cancer Research and Treatment. 121: 693-702. PMID 19921425 DOI: 10.1007/S10549-009-0633-5  0.352
2010 Hemminki K, Müller-Myhsok B, Lichtner P, Engel C, Chen B, Burwinkel B, Försti A, Sutter C, Wappenschmidt B, Hellebrand H, Illig T, Arnold N, Niederacher D, Dworniczak B, Deissler H, et al. Low-risk variants FGFR2, TNRC9 and LSP1 in German familial breast cancer patients. International Journal of Cancer. 126: 2858-2862. PMID 19856316 DOI: 10.1002/Ijc.24986  0.373
2010 Catucci I, Yang R, Verderio P, Pizzamiglio S, Heesen L, Hemminki K, Sutter C, Wappenschmidt B, Dick M, Arnold N, Bugert P, Niederacher D, Meindl A, Schmutzler RK, Bartram CC, et al. Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases Human Mutation. 31. PMID 19847796 DOI: 10.1002/Humu.21141  0.366
2010 Tchatchou S, Riedel A, Lyer S, Schmutzhard J, Strobel-Freidekind O, Gronert-Sum S, Mietag C, D'Amato M, Schlehe B, Hemminki K, Sutter C, Ditsch N, Blackburn A, Hill LZ, Jerry DJ, ... ... Arnold N, et al. Identification of a DMBT1 polymorphism associated with increased breast cancer risk and decreased promoter activity. Human Mutation. 31: 60-6. PMID 19830809 DOI: 10.1002/Humu.21134  0.447
2010 Gaudet MM, Kirchhoff T, Green T, Vijai J, Korn JM, Guiducci C, Segrè AV, McGee K, McGuffog L, Kartsonaki C, Morrison J, Healey S, Sinilnikova OM, Stoppa-Lyonnet D, Mazoyer S, ... ... Arnold N, et al. Correction: Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer Plos Genetics. 6. DOI: 10.1371/Annotation/B28Cf02D-7196-4A16-8B36-6562A0B84F75  0.374
2009 Hartmaier RJ, Tchatchou S, Richter AS, Wang J, McGuire SE, Skaar TC, Rae JM, Hemminki K, Sutter C, Ditsch N, Bugert P, Weber BH, Niederacher D, Arnold N, Varon-Mateeva R, et al. Nuclear receptor coregulator SNP discovery and impact on breast cancer risk. Bmc Cancer. 9: 438. PMID 20003447 DOI: 10.1186/1471-2407-9-438  0.41
2009 Osorio A, Milne RL, Pita G, Peterlongo P, Heikkinen T, Simard J, Chenevix-Trench G, Spurdle AB, Beesley J, Chen X, Healey S, Neuhausen SL, Ding YC, Couch FJ, ... ... Arnold N, et al. Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA). British Journal of Cancer. 101: 2048-54. PMID 19920816 DOI: 10.1038/Sj.Bjc.6605416  0.45
2009 Graeser MK, Engel C, Rhiem K, Gadzicki D, Bick U, Kast K, Froster UG, Schlehe B, Bechtold A, Arnold N, Preisler-Adams S, Nestle-Kraemling C, Zaino M, Loeffler M, Kiechle M, et al. Contralateral Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers Journal of Clinical Oncology. 27: 5887-5892. PMID 19858402 DOI: 10.1200/Jco.2008.19.9430  0.451
2009 Sinilnikova OM, Antoniou AC, Simard J, Healey S, Léoné M, Sinnett D, Spurdle AB, Beesley J, Chen X, Greene MH, Loud JT, Lejbkowicz F, Rennert G, Dishon S, ... ... Arnold N, et al. The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. British Journal of Cancer. 101: 1456-60. PMID 19707196 DOI: 10.1038/Sj.Bjc.6605279  0.421
2009 Antoniou AC, Sinilnikova OM, McGuffog L, Healey S, Nevanlinna H, Heikkinen T, Simard J, Spurdle AB, Beesley J, Chen X, Neuhausen SL, Ding YC, Couch FJ, Wang X, ... ... Arnold N, et al. Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers. Human Molecular Genetics. 18: 4442-56. PMID 19656774 DOI: 10.1093/Hmg/Ddp372  0.452
2009 Bug S, Dürig J, Oyen F, Klein-Hitpass L, Martin-Subero JI, Harder L, Baudis M, Arnold N, Kordes U, Dührsen U, Schneppenheim R, Siebert R. Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition. Cancer Genetics and Cytogenetics. 192: 44-7. PMID 19480937 DOI: 10.1016/J.Cancergencyto.2009.03.001  0.322
2009 Pfisterer J, Bois AD, Bentz E, Kommoss F, Harter P, Huober J, Schmalfeldt B, Burchardi N, Arnold N, Hilpert F. Prognostic value of human epidermal growth factor receptor 2 (Her-2)/neu in patients with advanced ovarian cancer treated with platinum/paclitaxel as first-line chemotherapy: a retrospective evaluation of the AGO-OVAR 3 Trial by the AGO OVAR Germany. International Journal of Gynecological Cancer. 19: 109-115. PMID 19258951 DOI: 10.1111/Igc.0B013E3181991A7C  0.31
2009 Yang R, Chen B, Hemminki K, Wappenschmidt B, Engel C, Sutter C, Ditsch N, Weber BHF, Niederacher D, Arnold N, Meindl A, Bartram CR, Schmutzler RK, Burwinkel B. Polymorphisms in BRCA2 resulting in aberrant codon-usage and their analysis on familial breast cancer risk. Breast Cancer Research and Treatment. 118: 407-413. PMID 19229607 DOI: 10.1007/S10549-009-0348-7  0.43
2009 Sadr-Nabavi A, Ramser J, Volkmann J, Naehrig J, Wiesmann F, Betz B, Hellebrand H, Engert S, Seitz S, Kreutzfeld R, Sasaki T, Arnold N, Schmutzler R, Kiechle M, Niederacher D, et al. Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker International Journal of Cancer. 124: 1727-1735. PMID 19115204 DOI: 10.1002/Ijc.24108  0.414
2009 Klein A, Olendrowitz C, Schmutzler R, Hampl J, Schlag PM, Maass N, Arnold N, Wessel R, Ramser J, Meindl A, Scherneck S, Seitz S. Identification of brain- and bone-specific breast cancer metastasis genes. Cancer Letters. 276: 212-20. PMID 19114293 DOI: 10.1016/J.Canlet.2008.11.017  0.34
2009 Tchatchou S, Jung A, Hemminki K, Sutter C, Wappenschmidt B, Bugert P, Weber BHF, Niederacher D, Arnold N, Varon-Mateeva R, Ditsch N, Meindl A, Schmutzler RK, Bartram CR, Burwinkel B. A variant affecting a putative miRNA target site in estrogen receptor (ESR) 1 is associated with breast cancer risk in premenopausal women. Carcinogenesis. 30: 59-64. PMID 19028706 DOI: 10.1093/Carcin/Bgn253  0.387
2009 Vater I, Wagner F, Kreuz M, Berger H, Martín-Subero JI, Pott C, Martinez-Climent JA, Klapper W, Krause K, Dyer MJ, Gesk S, Harder L, Zamo A, Dreyling M, Hasenclever D, ... Arnold N, et al. GeneChip analyses point to novel pathogenetic mechanisms in mantle cell lymphoma. British Journal of Haematology. 144: 317-31. PMID 19016712 DOI: 10.1111/J.1365-2141.2008.07443.X  0.314
2009 Yang R, Frank B, Hemminki K, Bartram CR, Wappenschmidt B, Sutter C, Kiechle M, Bugert P, Schmutzler RK, Arnold N, Weber BHF, Niederacher D, Meindl A, Burwinkel B. SNPs in ultraconserved elements and familial breast cancer risk. Carcinogenesis. 30: 351-355. PMID 18174240 DOI: 10.1093/Carcin/Bgm290  0.409
2009 Kast K, Schmutzler R, Distler W, Arnold N, Bartram C, Bick U, Froster U, Grimm T, Kreienberg R, Naestle-Kraemling C, Schlegelberger B, Wieacker P, Meindl A, Engel C. Prevalence Rates of Pathogenic Mutations in theBRCA1andBRCA2Genes in Families with Different Disease Histories: Results from the German Consortium for Hereditary Breast and Ovarian Cancer. Cancer Research. 69: 4073-4073. DOI: 10.1158/0008-5472.Sabcs-09-4073  0.428
2008 Osorio A, Pollán M, Pita G, Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Preisler-Adams S, Niederacher D, Hofmann W, Gadzicki D, Jakubowska A, Hamann U, Lubinski J, et al. An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BRCA1 and BRCA2 mutation carriers. British Journal of Cancer. 99: 974-7. PMID 18781154 DOI: 10.1038/Sj.Bjc.6604624  0.443
2008 Giefing M, Arnemann J, Martin-Subero JI, Nieländer I, Bug S, Hartmann S, Arnold N, Tiacci E, Frank M, Hansmann M, Küppers R, Siebert R. Identification of candidate tumour suppressor gene loci for Hodgkin and Reed-Sternberg cells by characterisation of homozygous deletions in classical Hodgkin lymphoma cell lines British Journal of Haematology. 142: 916-924. PMID 18671701 DOI: 10.1111/J.1365-2141.2008.07262.X  0.319
2008 Antoniou AC, Spurdle AB, Sinilnikova OM, Healey S, Pooley KA, Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Hofmann W, Sutter C, Niederacher D, Deissler H, Caldes T, et al. Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. American Journal of Human Genetics. 82: 937-48. PMID 18355772 DOI: 10.1016/J.Ajhg.2008.02.008  0.455
2008 Meinhold-Heerlein I, Bräutigam K, Bauerschlag DO, Maass N, Arnold N. Translationale Forschung in der gynäkologischen Onkologie: Serum-Tumormarker zur Früherkennung des Ovarialkarzinoms Geburtshilfe Und Frauenheilkunde. 68: 830-837. DOI: 10.1055/S-2008-1038858  0.361
2008 Bräutigam K, Bauerschlag DO, Maass N, Jonat W, Arnold N, Bauknecht T, Meinhold-Heerlein I. Synergistic effects of the PKCβII inhibitor enzastaurin and the antifolate pemetrexed in chemoresistant ovarian cancer cell lines Ejc Supplements. 6: 137. DOI: 10.1016/S1359-6349(08)71700-2  0.325
2007 Antoniou AC, Sinilnikova OM, Simard J, Léoné M, Dumont M, Neuhausen SL, Struewing JP, Stoppa-Lyonnet D, Barjhoux L, Hughes DJ, Coupier I, Belotti M, Lasset C, Bonadona V, Bignon YJ, ... ... Arnold N, et al. RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies. American Journal of Human Genetics. 81: 1186-200. PMID 17999359 DOI: 10.1086/522611  0.426
2007 Vaclavicek A, Bermejo JL, Schmutzler RK, Sutter C, Wappenschmidt B, Meindl A, Kiechle M, Arnold N, Weber BHF, Niederacher D, Burwinkel B, Bartram CR, Hemminki K, Försti A. Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer Endocrine-Related Cancer. 14: 267-277. PMID 17639043 DOI: 10.1677/Erc-06-0077  0.359
2007 Klein A, Wessel R, Graessmann M, Jürgens M, Petersen I, Schmutzler R, Niederacher D, Arnold N, Meindl A, Scherneck S, Seitz S, Graessmann A. Comparison of gene expression data from human and mouse breast cancers: identification of a conserved breast tumor gene set. International Journal of Cancer. Journal International Du Cancer. 121: 683-8. PMID 17410534 DOI: 10.1002/Ijc.22630  0.398
2007 Hammer S, Arnold N, Hilpert F, Bräutigam K, Sommer A, Winsel S, Klar U, Hoffmann J. 5009 ORAL Significant antitumour activity of the novel epothilone ZK-EPO against in vitro and in vivo models of ovarian cancer Ejc Supplements. 5: 313-314. DOI: 10.1016/S1359-6349(07)71181-3  0.315
2006 Wirtenberger M, Schmutzhard J, Hemminki K, Meindl A, Sutter C, Schmutzler RK, Wappenschmidt B, Kiechle M, Arnold N, Weber BHF, Niederacher D, Bartram CR, Burwinkel B. The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer. Carcinogenesis. 28: 423-426. PMID 16956908 DOI: 10.1093/Carcin/Bgl164  0.427
2006 Wirtenberger M, Tchatchou S, Hemminki K, Schmutzhard J, Sutter C, Schmutzler RK, Meindl A, Wappenschmidt B, Kiechle M, Arnold N, Weber BHF, Niederacher D, Bartram CR, Burwinkel B. Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer Carcinogenesis. 27: 2201-2208. PMID 16704985 DOI: 10.1093/Carcin/Bgl067  0.449
2006 Seitz S, Korsching E, Weimer J, Jacobsen A, Arnold N, Meindl A, Arnold W, Gustavus D, Klebig C, Petersen I, Scherneck S. Genetic background of different cancer cell lines influences the gene set involved in chromosome 8 mediated tumor suppression Genes Chromosomes and Cancer. 45: 612-627. PMID 16552773 DOI: 10.1002/Gcc.20325  0.411
2006 Sommer A, Hilpert F, Arnold N. Gene Expression Profiling of Epithelial Ovarian Cancer Current Genomics. 7: 115-135. DOI: 10.2174/138920206777304641  0.334
2006 Sontag B, Rüth M, Spiteller P, Arnold N, Steglich W, Reichert M, Bringmann G. Chromogenic Meroterpenoids from the MushroomsRussula ochroleuca andR. viscida European Journal of Organic Chemistry. 2006: 1023-1033. DOI: 10.1002/Ejoc.200500714  0.406
2005 Wirtenberger M, Frank B, Hemminki K, Klaes R, Schmutzler RK, Wappenschmidt B, Meindl A, Kiechle M, Arnold N, Weber BHF, Niederacher D, Bartram CR, Burwinkel B. Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer. Carcinogenesis. 27: 1655-1660. PMID 16501249 DOI: 10.1093/Carcin/Bgi374  0.453
2005 Wappenschmidt B, Fimmers R, Rhiem K, Brosig M, Wardelmann E, Meindl A, Arnold N, Mallmann P, Schmutzler RK. Strong evidence that the common variant S384F in BRCA2 has no pathogenic relevance in hereditary breast cancer. Breast Cancer Research : Bcr. 7: R775-9. PMID 16168123 DOI: 10.1186/Bcr1291  0.446
2005 Seitz S, Frege R, Jacobsen A, Weimer J, Arnold W, Von Haefen C, Niederacher D, Schmutzler R, Arnold N, Scherneck S. A network of clinically and functionally relevant genes is involved in the reversion of the tumorigenic phenotype of MDA-MB-231 breast cancer cells after transfer of human chromosome 8 Oncogene. 24: 869-879. PMID 15580292 DOI: 10.1038/Sj.Onc.1208260  0.402
2005 Meinhold-Heerlein I, Bauerschlag D, Hilpert F, Dimitrov P, Sapinoso LM, Orlowska-Volk M, Bauknecht T, Park TW, Jonat W, Jacobsen A, Sehouli J, Luttges J, Krajewski M, Krajewski S, Reed JC, ... Arnold N, et al. Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential. Oncogene. 24: 1053-65. PMID 15558012 DOI: 10.1038/Sj.Onc.1208298  0.303
2005 Strissel J, Seitz S, Arnold W, Weimer J, Jacobsen A, Arnold N, Scherneck S. Microcell-mediated transfer of chromosome 6 into the breast cancer cell line MDA-MB-231: a specific set of genes is involved in the reversion of the tumorigenic phenotype Breast Cancer Research. 7: 1-2. DOI: 10.1186/Bcr1144  0.412
2005 Seitz S, Korsching E, Weimer J, Jacobsen A, Arnold N, Meindl A, Arnold W, Gustavus D, Klebig C, Petersen I, Scherneck S. Identification of clinically relevant gene sets and pathways using functional models of breast tumor suppression Breast Cancer Research. 7: 1-1. DOI: 10.1186/Bcr1143  0.41
2005 Trautmann H, Starczynowski DT, Pott C, Harder L, Arnold N, Siebert R, Kneba M, Gilmore TD. An Activating Mutation (Ser525Pro) within the Transactivation Domain of REL in Two Patients with Human B-Cell Lymphomas Enhances REL’s In Vitro Transforming Activity. Blood. 106: 2617-2617. DOI: 10.1182/Blood.V106.11.2617.2617  0.303
2004 Hartmann C, John AL, Klaes R, Hofmann W, Bielen R, Koehler R, Janssen B, Bartram CR, Arnold N, Zschocke J. Large BRCA1 gene deletions are found in 3% of German high-risk breast cancer families. Human Mutation. 24: 534. PMID 15532023 DOI: 10.1002/Humu.9291  0.418
2004 Dufault MR, Betz B, Wappenschmidt B, Hofmann W, Bandick K, Golla A, Pietschmann A, Nestle-Krämling C, Rhiem K, Hüttner C, Von Lindern C, Dall P, Kiechle M, Untch M, Jonat W, ... ... Arnold N, et al. Limited relevance of the CHEK2 gene in hereditary breast cancer International Journal of Cancer. 110: 320-325. PMID 15095295 DOI: 10.1002/Ijc.20073  0.453
2003 Spiteller P, Arnold N, Spiteller M, Steglich W. Lilacinone, a red aminobenzoquinone pigment from Lactarius lilacinus. Journal of Natural Products. 66: 1402-3. PMID 14575448 DOI: 10.1021/Np0303052  0.408
2003 Hofmann W, Görgens H, John A, Horn D, Hüttner C, Arnold N, Scherneck S, Schackert HK. Screening for large rearrangements of the BRCA1 gene in German breast or ovarian cancer families using semi-quantitative multiplex PCR method. Human Mutation. 22: 103-4. PMID 12815601 DOI: 10.1002/Humu.9154  0.419
2003 Hilpert F, Schemm S, Arnold N, Jonat W. Klinik, Histopathologie und Molekularbiologie des Tubenkarzinoms Geburtshilfe Und Frauenheilkunde. 63: 853-859. DOI: 10.1055/S-2003-42572  0.351
2003 Lück HJ, Kommoss F, Riener E, Arnold N, Adams HP, Hilpert F, Bois AD, Pfisterer J. 41 HER2-expression in advanced ovarian cancer: A prognostic and predictive marker? An study of the AGO ovarian study group Ejc Supplements. 1. DOI: 10.1016/S1359-6349(03)90075-9  0.324
2002 Arnold N, Peper H, Bandick K, Kreikemeier M, Karow D, Teegen B, Jonat W. Establishing a control population to screen for the occurrence of nineteen unclassified variants in the BRCA1 gene by denaturing high-performance liquid chromatography. Journal of Chromatography B. 782: 99-104. PMID 12457999 DOI: 10.1016/S1570-0232(02)00696-7  0.424
2001 Reifenberger J, Arnold N, Kiechle M, Reifenberger G, Hauschild A. Coincident PTCH and BRCA1 germline mutations in a patient with nevoid basal cell carcinoma syndrome and familial breast cancer. Journal of Investigative Dermatology. 116: 472-474. PMID 11231326 DOI: 10.1046/J.1523-1747.2001.01279-2.X  0.405
2001 Gross E, Kiechle M, Arnold N. Mutation analysis of p53 in ovarian tumors by DHPLC Journal of Biochemical and Biophysical Methods. 47: 73-81. PMID 11179763 DOI: 10.1016/S0165-022X(00)00153-6  0.35
2001 Kiechle M, Jacobsen BSA, Schwarz-Boeger U, Hedderich BSJ, Pfisterer J, Arnold N. Comparative genomic hybridization detects genetic imbalances in primary ovarian carcinomas as correlated with grade of differentiation. Cancer. 91: 534-540. PMID 11169935 DOI: 10.1002/1097-0142(20010201)91:3<534::Aid-Cncr1031>3.0.Co;2-T  0.324
2000 Kiechle M, Gross E, Schwarz-Boeger U, Pfisterer J, Jonat W, Gerber W, Albacht B, Fischer B, Schlegelberger B, Arnold N. Ten novel BRCA1 and BRCA2 mutations in breast and/or ovarian cancer families from northern Germany. Human Mutation. 16: 529-530. PMID 11102986 DOI: 10.1002/1098-1004(200012)16:6<529::Aid-Humu14>3.0.Co;2-K  0.393
2000 Gross E, Arnold N, Pfeifer K, Bandick K, Kiechle M. Identification of specific BRCA1 and BRCA2 variants by DHPLC Human Mutation. 16: 345-353. PMID 11013445 DOI: 10.1002/1098-1004(200010)16:4<345::AID-HUMU7>3.0.CO;2-#  0.366
2000 Aulinger K, Arnold N, Steglich W. Metabolites of 2-aminophenol from fruit bodies of Lepiota americana (Agaricales). Zeitschrift Fur Naturforschung. C, Journal of Biosciences. 55: 481-4. PMID 10928564 DOI: 10.1515/Znc-2000-5-628  0.406
2000 Kiechle M, Hinrichs M, Jacobsen A, Lüttges J, Pfisterer J, Kommoss F, Arnold N. Genetic imbalances in precursor lesions of endometrial cancer detected by comparative genomic hybridization. American Journal of Pathology. 156: 1827-1833. PMID 10854205 DOI: 10.1016/S0002-9440(10)65055-9  0.329
1999 Sontag B, Arnold N, Steglich W, Anke T. Montadial A, a cytotoxic metabolite from Bondarzewia montana. Journal of Natural Products. 62: 1425-6. PMID 10543907 DOI: 10.1021/Np9900876  0.406
1999 Arnold N, Gross E, Schwarz-Boeger U, Pfisterer J, Jonat W, Kiechle M. A highly sensitive, fast, and economical technique for mutation analysis in hereditary breast and ovarian cancers. Human Mutation. 14: 333-339. PMID 10502781 DOI: 10.1002/(Sici)1098-1004(199910)14:4<333::Aid-Humu9>3.0.Co;2-C  0.386
1999 Gross E, Arnold N, Goette J, Schwarz-Boeger U, Kiechle M. A comparison of BRCA1 mutation analysis by direct sequencing, SSCP and DHPLC. Human Genetics. 105: 72-78. PMID 10480358 DOI: 10.1007/S004399900092  0.346
1999 Arnold N, Groß E, Schwarz-Boeger U, Pfisterer J, Jonat W, Kiechle M. A Fast, Highly Sensitive and Cheap Tool for Mutation Analysis of Complex Genes Disease Markers. 15: 118-118. DOI: 10.1155/1999/473180  0.31
1999 Sontag B, Dasenbrock J, Arnold N, Steglich W. Metabolites from the Wood-Rotting BasidiomyceteHapalopilusmutans (Aphyllophorales) European Journal of Organic Chemistry. 1999: 1051-1055. DOI: 10.1002/(Sici)1099-0690(199905)1999:5<1051::Aid-Ejoc1051>3.0.Co;2-9  0.413
1997 Ye Y, Aulinger K, Arnold N, Spahl W, Steglich W. Biosynthesis of the Azoxycarboxamide Lyophyllin and Formation of Some of its Unnatural Analogues in Fruit-bodies of Lyophyllum connatum Tetrahedron Letters. 38: 8013-8016. DOI: 10.1016/S0040-4039(97)10177-0  0.39
1996 Arnold N, Hägele L, Walz L, Schempp W, Pfisterer J, Bauknecht T, Kiechle M. Overrepresentation of 3q and 8q material and loss of 18q material are recurrent findings in advanced human ovarian cancer Genes, Chromosomes and Cancer. 16: 46-54. PMID 9162197 DOI: 10.1002/(Sici)1098-2264(199605)16:1<46::Aid-Gcc7>3.0.Co;2-3  0.308
1996 Ye Y, Josten I, Arnold N, Steffan B, Steglich W. Isolation of a fluorone pigment from the Indian paint fungus Echinodontium tinctorium and Pyrofomes albomarginatus Tetrahedron. 52: 5793-5798. DOI: 10.1016/0040-4020(96)00204-9  0.399
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