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Katherine J. Wert, PhD - Publications

Affiliations: 
Whitehead Massachusetts Institute of Technology, Cambridge, MA, United States 
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Yee T, Wert KJ. Human retina-in-a-dish: Unlocking the potential to study mechanisms of inherited retinal disease. Molecular Therapy. Methods & Clinical Development. 30: 573-575. PMID 37693947 DOI: 10.1016/j.omtm.2023.08.019  0.396
2023 Kong Y, Liu PK, Li Y, Nolan ND, Quinn PMJ, Hsu CW, Jenny LA, Zhao J, Cui X, Chang YJ, Wert KJ, Sparrow JR, Wang NK, Tsang SH. HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy. Embo Molecular Medicine. e16525. PMID 36645044 DOI: 10.15252/emmm.202216525  0.564
2022 Rowe AA, Chen X, Nettesheim ER, Issioui Y, Dong T, Hu Y, Messahel S, Kayani SN, Gray SJ, Wert KJ. Long-term progression of retinal degeneration in a preclinical model of CLN7 Batten disease as a baseline for testing clinical therapeutics. Ebiomedicine. 85: 104314. PMID 36374771 DOI: 10.1016/j.ebiom.2022.104314  0.325
2022 Yee T, Wert KJ. Base and Prime Editing in the Retina-From Preclinical Research toward Human Clinical Trials. International Journal of Molecular Sciences. 23. PMID 36293232 DOI: 10.3390/ijms232012375  0.386
2021 Rowe AA, Patel PD, Gordillo R, Wert KJ. Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa. Jci Insight. PMID 34292885 DOI: 10.1172/jci.insight.150898  0.43
2020 Tang PH, Chemudupati T, Wert KJ, Folk JC, Mahajan M, Tsang SH, Bassuk AG, Mahajan VB. Phenotypic variance in Calpain-5 retinal degeneration. American Journal of Ophthalmology Case Reports. 18: 100627. PMID 32274441 DOI: 10.1016/J.Ajoc.2020.100627  0.554
2020 Wert KJ, Velez G, Kanchustambham VL, Shankar V, Evans LP, Sengillo JD, Zare RN, Bassuk AG, Tsang SH, Mahajan VB. Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration. Ebiomedicine. 52: 102636. PMID 32028070 DOI: 10.1016/J.Ebiom.2020.102636  0.582
2019 Wert KJ, Koch SF, Velez G, Hsu CW, Mahajan M, Bassuk AG, Tsang SH, Mahajan VB. CAPN5 genetic inactivation phenotype supports therapeutic inhibition trials. Human Mutation. PMID 31403230 DOI: 10.1002/Humu.23894  0.634
2019 Wert KJ, Bakall B, Bassuk AG, Tsang SH, Mahajan VB. Insights into Retinal Development Using Live Imaging in Female Carriers of Choroideremia. Ophthalmic Surgery, Lasers & Imaging Retina. 50: e158-e162. PMID 31100169 DOI: 10.3928/23258160-20190503-15  0.548
2019 Wert KJ, Mahajan VB. In Vivo Expression of Mutant Calpains in the Eye Using Lentivirus. Methods in Molecular Biology (Clifton, N.J.). 1915: 233-247. PMID 30617808 DOI: 10.1007/978-1-4939-8988-1_18  0.365
2018 Wert KJ, Velez G, Cross MR, Wagner BA, Teoh-Fitzgerald ML, Buettner GR, McAnany J, Olivier A, Tsang SH, Harper MM, Domann FE, Bassuk AG, Mahajan VB. Extracellular superoxide dismutase 3 (SOD3) regulates oxidative stress at the vitreoretinal interface. Free Radical Biology & Medicine. PMID 29940351 DOI: 10.1016/J.Freeradbiomed.2018.06.024  0.441
2018 Ma H, Wert KJ, Shvartsman D, Melton DA, Jaenisch R. Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas. Proceedings of the National Academy of Sciences of the United States of America. PMID 29599125 DOI: 10.1073/Pnas.1702059115  0.355
2016 Theunissen TW, Friedli M, He Y, Planet E, O'Neil RC, Markoulaki S, Pontis J, Wang H, Iouranova A, Imbeault M, Duc J, Cohen MA, Wert KJ, Castanon R, Zhang Z, et al. Molecular Criteria for Defining the Naive Human Pluripotent State. Cell Stem Cell. PMID 27424783 DOI: 10.1016/J.Stem.2016.06.011  0.323
2016 Wert KJ, Mahajan VB, Zhang L, Yan Y, Li Y, Tosi J, Hsu CW, Nagasaki T, Janisch KM, Grant MB, Mahajan M, Bassuk AG, Tsang SH. Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy. Signal Transduction and Targeted Therapy. 1. PMID 27195131 DOI: 10.1038/Sigtrans.2016.5  0.68
2016 Cohen MA, Wert KJ, Goldmann J, Markoulaki S, Buganim Y, Fu D, Jaenisch R. Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos. Proceedings of the National Academy of Sciences of the United States of America. PMID 26811475 DOI: 10.1073/Pnas.1525518113  0.364
2015 D'Alessio AC, Fan ZP, Wert KJ, Baranov P, Cohen MA, Saini JS, Cohick E, Charniga C, Dadon D, Hannett NM, Young MJ, Temple S, Jaenisch R, Lee TI, Young RA. A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity. Stem Cell Reports. PMID 26603904 DOI: 10.1016/J.Stemcr.2015.09.016  0.367
2015 Wert KJ, Bassuk AG, Wu WH, Gakhar L, Coglan D, Mahajan M, Wu S, Yang J, Lin CS, Tsang SH, Mahajan VB. CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model. Human Molecular Genetics. 24: 4584-98. PMID 25994508 DOI: 10.1093/Hmg/Ddv189  0.582
2015 Wert KJ, Bassuk AG, Wu WH, Gakhar L, Coglan D, Mahajan M, Wu S, Yang J, Lin CS, Tsang SH, Mahajan VB. CAPN5 mutation in hereditary uveitis: The R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model Human Molecular Genetics. 24: 4584-4598. DOI: 10.1093/hmg/ddv189  0.329
2014 Tsang SH, Chan L, Tsai YT, Wu WH, Hsu CW, Yang J, Tosi J, Wert KJ, Davis RJ, Mahajan VB. Silencing of tuberin enhances photoreceptor survival and function in a preclinical model of retinitis pigmentosa (an american ophthalmological society thesis). Transactions of the American Ophthalmological Society. 112: 103-15. PMID 25646031  0.683
2014 Wert KJ, Lin JH, Tsang SH. General pathophysiology in retinal degeneration. Developments in Ophthalmology. 53: 33-43. PMID 24732759 DOI: 10.1159/000357294  0.618
2014 Wert KJ, Skeie JM, Bassuk AG, Olivier AK, Tsang SH, Mahajan VB. Functional validation of a human CAPN5 exome variant by lentiviral transduction into mouse retina. Human Molecular Genetics. 23: 2665-77. PMID 24381307 DOI: 10.1093/Hmg/Ddt661  0.586
2014 Wert KJ, Sancho-Pelluz J, Tsang SH. Mid-stage intervention achieves similar efficacy as conventional early-stage treatment using gene therapy in a pre-clinical model of retinitis pigmentosa. Human Molecular Genetics. 23: 514-23. PMID 24101599 DOI: 10.1093/Hmg/Ddt452  0.572
2014 Tsang SH, Chan L, Tsai YT, Wu WH, Hsu CW, Yang J, Tosi J, Wert KJ, Davis RJ, Mahajan VB. Silencing of tuberin enhances photoreceptor survival and function in a preclinical model of retinitis pigmentosa (an American ophthalmological society thesis) Transactions of the American Ophthalmological Society. 112: 103-115.  0.691
2013 Davis RJ, Hsu CW, Tsai YT, Wert KJ, Sancho-Pelluz J, Lin CS, Tsang SH. Therapeutic margins in a novel preclinical model of retinitis pigmentosa. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 13475-83. PMID 23946405 DOI: 10.1523/Jneurosci.0419-13.2013  0.602
2013 Wert KJ, Davis RJ, Sancho-Pelluz J, Nishina PM, Tsang SH. Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa. Human Molecular Genetics. 22: 558-67. PMID 23108158 DOI: 10.1093/Hmg/Dds466  0.631
2012 Wert KJ, Skeie JM, Davis RJ, Tsang SH, Mahajan VB. Subretinal injection of gene therapy vectors and stem cells in the perinatal mouse eye. Journal of Visualized Experiments : Jove. PMID 23207897 DOI: 10.3791/4286  0.561
2010 Nan-Kai W, Tosi J, Kasanuki JM, Chou CL, Kong J, Parmalee N, Wert KJ, Allikmets R, Lai CC, Chien CL, Nagasaki T, Lin CS, Tsang SH. Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for Retinitis Pigmentosa: Transplantation 2010 April 27;89 (8): 911-919. Annals of Neurosciences. 17: 185-6. PMID 25205903 DOI: 10.5214/Ans.0972.7531.1017408  0.691
2010 Wang NK, Tosi J, Kasanuki JM, Chou CL, Kong J, Parmalee N, Wert KJ, Allikmets R, Lai CC, Chien CL, Nagasaki T, Lin CS, Tsang SH. Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa. Transplantation. 89: 911-9. PMID 20164818 DOI: 10.1097/Tp.0B013E3181D45A61  0.721
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