| Year |
Citation |
Score |
| 2023 |
Mushtaq A, Wu P, Naseer MM. Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets. Pharmacology & Therapeutics. 254: 108579. PMID 38160914 DOI: 10.1016/j.pharmthera.2023.108579 |
0.31 |
|
| 2023 |
Borgelt L, Hohnen L, Pallesen JS, Hommen P, Goebel GL, Bosica F, Liu Y, O'Mahony G, Wu P. -Biphenyl Pyrrolinones and Dibenzofurans as RNA-Binding Protein LIN28 Inhibitors Disrupting the LIN28- Interaction. Acs Medicinal Chemistry Letters. 14: 1707-1715. PMID 38116413 DOI: 10.1021/acsmedchemlett.3c00341 |
0.838 |
|
| 2023 |
Borgelt L, Wu P. Targeting Ribonucleases with Small Molecules and Bifunctional Molecules. Acs Chemical Biology. PMID 37382390 DOI: 10.1021/acschembio.3c00191 |
0.748 |
|
| 2023 |
Hommen P, Hwang J, Huang F, Borgelt L, Hohnen L, Wu P. Chromenopyrazole-peptide conjugates as small-molecule based inhibitors disrupting the protein-RNA interaction of LIN28-let-7. Chembiochem : a European Journal of Chemical Biology. e202300376. PMID 37224100 DOI: 10.1002/cbic.202300376 |
0.803 |
|
| 2023 |
Hwang J, Haacke N, Borgelt L, Qiu X, Gasper R, Wu P. Rational design and evaluation of 2-((pyrrol-2-yl)methylene)thiophen-4-ones as RNase L inhibitors. European Journal of Medicinal Chemistry. 256: 115439. PMID 37201427 DOI: 10.1016/j.ejmech.2023.115439 |
0.841 |
|
| 2023 |
Borgelt L, Huang F, Hohnen L, Qiu X, Goebel GL, Hommen P, Wu P. Spirocyclic Chromenopyrazole Inhibitors Disrupting the Interaction between the RNA-binding protein LIN28 and Let-7. Chembiochem : a European Journal of Chemical Biology. e202300168. PMID 37129525 DOI: 10.1002/cbic.202300168 |
0.826 |
|
| 2022 |
Borgelt L, Haacke N, Lampe P, Qiu X, Gasper R, Schiller D, Hwang J, Sievers S, Wu P. Small-molecule screening of ribonuclease L binders for RNA degradation. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 154: 113589. PMID 36029542 DOI: 10.1016/j.biopha.2022.113589 |
0.791 |
|
| 2022 |
Goebel GL, Qiu X, Wu P. Kinase-targeting small-molecule inhibitors and emerging bifunctional molecules. Trends in Pharmacological Sciences. PMID 35589447 DOI: 10.1016/j.tips.2022.04.006 |
0.816 |
|
| 2022 |
Song H, Wang C, Zhu C, Wang Z, Yang H, Wu P, Cui X, Botas J, Dang Y, Ding Y, Fei Y, Lu B. Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide. Proceedings of the National Academy of Sciences of the United States of America. 119: e2114303119. PMID 35238684 DOI: 10.1073/pnas.2114303119 |
0.325 |
|
| 2022 |
Hwang J, Qiu X, Borgelt L, Haacke N, Kanis L, Petroulia S, Gasper R, Schiller D, Lampe P, Sievers S, Imig J, Wu P. Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents. Bioorganic & Medicinal Chemistry. 58: 116653. PMID 35152173 DOI: 10.1016/j.bmc.2022.116653 |
0.716 |
|
| 2021 |
Goebel GL, Hohnen L, Borgelt L, Hommen P, Qiu X, Lightfoot H, Wu P. Small molecules with tetrahydroquinoline-containing Povarov scaffolds as inhibitors disrupting the Protein-RNA interaction of LIN28-let-7. European Journal of Medicinal Chemistry. 228: 114014. PMID 34883291 DOI: 10.1016/j.ejmech.2021.114014 |
0.768 |
|
| 2021 |
Borgelt L, Li F, Hommen P, Lampe P, Hwang J, Goebel GL, Sievers S, Wu P. Trisubstituted Pyrrolinones as Small-Molecule Inhibitors Disrupting the Protein-RNA Interaction of LIN28 and . Acs Medicinal Chemistry Letters. 12: 893-898. PMID 34136077 DOI: 10.1021/acsmedchemlett.0c00546 |
0.833 |
|
| 2020 |
Wu P. Inhibition of RNA-binding proteins with small molecules. Nature Reviews. Chemistry. 4: 441-458. PMID 37127961 DOI: 10.1038/s41570-020-0201-4 |
0.481 |
|
| 2020 |
Hwang J, Borgelt L, Wu P. Multicomponent Petasis Reaction for the Synthesis of Functionalized 2-Aminothiophenes and Thienodiazepines. Acs Combinatorial Science. PMID 32985878 DOI: 10.1021/acscombsci.0c00173 |
0.776 |
|
| 2020 |
Siriwardena SU, Munkanatta Godage DNP, Shoba VM, Lai S, Shi M, Wu P, Chaudhary SK, Schreiber SL, Choudhary A. Phosphorylation-Inducing Chimeric Small Molecules. Journal of the American Chemical Society. PMID 32787262 DOI: 10.1021/Jacs.0C05537 |
0.76 |
|
| 2020 |
Manna D, Wu P. Optochemical control of protein degradation. Chembiochem : a European Journal of Chemical Biology. PMID 32227452 DOI: 10.1002/Cbic.202000113 |
0.686 |
|
| 2019 |
Wu P, Givskov M, Nielsen TE. Reactivity and Synthetic Applications of Multicomponent Petasis Reactions. Chemical Reviews. PMID 31454230 DOI: 10.1021/Acs.Chemrev.9B00214 |
0.63 |
|
| 2019 |
Maji B, Gangopadhyay SA, Lee M, Shi M, Wu P, Heler R, Mok B, Lim D, Siriwardena SU, Paul B, Dančík V, Vetere A, Mesleh MF, Marraffini LA, Liu DR, et al. A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9. Cell. 177: 1067-1079.e19. PMID 31051099 DOI: 10.1016/J.Cell.2019.04.009 |
0.781 |
|
| 2018 |
Wu P, Nielsen TE. Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds. Drug Discovery Today. Technologies. 29: 27-33. PMID 30471670 DOI: 10.1016/J.Ddtec.2018.06.010 |
0.662 |
|
| 2018 |
Liao G, Yang D, Ma L, Li W, Hu L, Zeng L, Wu P, Duan L, Liu Z. The development of piperidinones as potent MDM2-P53 protein-protein interaction inhibitors for cancer therapy. European Journal of Medicinal Chemistry. 159: 1-9. PMID 30253242 DOI: 10.1016/j.ejmech.2018.09.044 |
0.319 |
|
| 2017 |
Hamadani KM, Howe J, Jensen MK, Wu P, Cate JHD, Marqusee S. An in-vitro tag-and-modify protein sample generation method for singlemolecule FRET. The Journal of Biological Chemistry. PMID 28754692 DOI: 10.1074/Jbc.M117.791723 |
0.459 |
|
| 2017 |
Ishoey M, Petersen RG, Petersen MÅ, Wu P, Clausen MH, Nielsen TE. Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels-Alder and ROM-RCM reactions. Chemical Communications (Cambridge, England). PMID 28714998 DOI: 10.1039/C7Cc02948A |
0.593 |
|
| 2017 |
Wang Z, Yang L, Fan H, Wu P, Zhang F, Zhang C, Liu W, Li M. Screening of a natural compound library identifies emodin, a natural compound from Rheum palmatum Linn that inhibits DPP4. Peerj. 5: e3283. PMID 28507818 DOI: 10.7717/peerj.3283 |
0.312 |
|
| 2017 |
Wu P, Nielsen TE. Scaffold Diversity from N-Acyliminium Ions. Chemical Reviews. PMID 28493667 DOI: 10.1021/Acs.Chemrev.6B00806 |
0.57 |
|
| 2016 |
Wu P, Petersen MÅ, Cohrt AE, Petersen R, Morgentin R, Lemoine H, Roche C, Willaume A, Clausen MH, Nielsen TE. A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production. Organic & Biomolecular Chemistry. PMID 27356738 DOI: 10.1039/C6Ob01148A |
0.654 |
|
| 2016 |
Wu P, Petersen MÅ, Petersen R, Flagstad T, Guilleux R, Ohsten M, Morgentin R, Nielsen TE, Clausen MH. Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries Rsc Advances. 6: 46654-46657. DOI: 10.1039/C6Ra08786H |
0.515 |
|
| 2015 |
Wu P, Clausen MH, Nielsen TE. Allosteric small-molecule kinase inhibitors. Pharmacology & Therapeutics. PMID 26478442 DOI: 10.1016/J.Pharmthera.2015.10.002 |
0.729 |
|
| 2015 |
Wu P, Wang L, Cowling BJ, Yu J, Fang VJ, Li F, Zeng L, Wu JT, Li Z, Leung GM, Yu H. Live Poultry Exposure and Public Response to Influenza A(H7N9) in Urban and Rural China during Two Epidemic Waves in 2013-2014. Plos One. 10: e0137831. PMID 26367002 DOI: 10.1371/journal.pone.0137831 |
0.341 |
|
| 2015 |
Wu P, Nielsen TE, Clausen MH. Small-molecule kinase inhibitors: an analysis of FDA-approved drugs. Drug Discovery Today. PMID 26210956 DOI: 10.1016/J.Drudis.2015.07.008 |
0.719 |
|
| 2015 |
Lv X, Ying H, Ma X, Qiu N, Wu P, Yang B, Hu Y. Design, synthesis and biological evaluation of novel 4-alkynyl-quinoline derivatives as PI3K/mTOR dual inhibitors. European Journal of Medicinal Chemistry. 99: 36-50. PMID 26046312 DOI: 10.1016/J.Ejmech.2015.05.025 |
0.517 |
|
| 2015 |
Wu P, Nielsen TE, Clausen MH. FDA-approved small-molecule kinase inhibitors. Trends in Pharmacological Sciences. 36: 422-39. PMID 25975227 DOI: 10.1016/J.Tips.2015.04.005 |
0.728 |
|
| 2015 |
Zhao X, Fang Y, Yang Y, Qin Y, Wu P, Wang T, Lai H, Meng L, Wang D, Zheng Z, Lu X, Zhang H, Gao Q, Zhou J, Ma D. Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells. Autophagy. 0. PMID 25893854 DOI: 10.1080/15548627.2015.1017185 |
0.3 |
|
| 2015 |
Petersen R, Cohrt AE, Petersen MÅ, Wu P, Clausen MH, Nielsen TE. Synthesis of hexahydropyrrolo[2,1-a]isoquinoline compound libraries through a Pictet-Spengler cyclization/metal-catalyzed cross coupling/amidation sequence. Bioorganic & Medicinal Chemistry. 23: 2646-9. PMID 25703308 DOI: 10.1016/J.Bmc.2015.01.039 |
0.655 |
|
| 2015 |
Nordstrøm LU, Sironi J, Aranda E, Maisonet J, Perez-Soler R, Wu P, Schwartz EL. Discovery of autophagy inhibitors with antiproliferative activity in lung and pancreatic cancer cells. Acs Medicinal Chemistry Letters. 6: 134-9. PMID 25699157 DOI: 10.1021/Ml500348P |
0.301 |
|
| 2015 |
Petersen MÅ, Mortensen MA, Cohrt AE, Petersen R, Wu P, Fleury-Brégeot N, Morgentin R, Lardy C, Nielsen TE, Clausen MH. Synthesis of 1,4,5 trisubstituted γ-lactams via a 3-component cascade reaction. Bioorganic & Medicinal Chemistry. 23: 2695-8. PMID 25684425 DOI: 10.1016/J.Bmc.2015.01.041 |
0.652 |
|
| 2015 |
Wu P, Petersen MÅ, Petersen R, Rasmussen MO, Bonnet K, Nielsen TE, Clausen MH. Synthesis of (Arylamido)pyrrolidinone Libraries through Ritter-Type Cascade Reactions of Dihydroxylactams European Journal of Organic Chemistry. 2015: 5633-5639. DOI: 10.1002/Ejoc.201500712 |
0.492 |
|
| 2014 |
Wang L, Cowling BJ, Wu P, Yu J, Li F, Zeng L, Wu JT, Li Z, Leung GM, Yu H. Human exposure to live poultry and psychological and behavioral responses to influenza A(H7N9), China. Emerging Infectious Diseases. 20: 1296-305. PMID 25076186 DOI: 10.3201/Eid2008.131821 |
0.342 |
|
| 2013 |
Liu Y, Si M, Tang L, Shangguan S, Wu H, Li J, Wu P, Ma X, Liu T, Hu Y. Synthesis and biological evaluation of novel benzyl-substituted (S)-phenylalanine derivatives as potent dipeptidyl peptidase 4 inhibitors. Bioorganic & Medicinal Chemistry. 21: 5679-87. PMID 23938053 DOI: 10.1016/J.Bmc.2013.07.034 |
0.476 |
|
| 2013 |
Zhang J, Wu P, Hu Y. Clinical and marketed proteasome inhibitors for cancer treatment. Current Medicinal Chemistry. 20: 2537-2551. PMID 23531219 DOI: 10.2174/09298673113209990122 |
0.483 |
|
| 2013 |
Liu Y, Wu Y, Wu H, Tang L, Wu P, Liu T, Hu Y. Design, synthesis, biological evaluation, and docking studies of (s)-phenylalanine derivatives with a 2-cyanopyrrolidine moiety as potent dipeptidyl peptidase 4 inhibitors. Chemical Biology & Drug Design. 82: 140-6. PMID 23530834 DOI: 10.1111/Cbdd.12139 |
0.495 |
|
| 2013 |
Liu Y, Jiang C, Wu H, Wu P, Si M, Hu Y, Liu T. Design, Synthesis and Biological Evaluation of Novel Imidazolone Derivatives as Dipeptidyl Peptidase 4 Inhibitors Medicinal Chemistry. 9: 938-946. PMID 23083118 DOI: 10.2174/1573406411309070007 |
0.424 |
|
| 2012 |
Wu P, Su Y, Guan X, Liu X, Zhang J, Dong X, Huang W, Hu Y. Identification of novel piperazinylquinoxaline derivatives as potent phosphoinositide 3-kinase (PI3K) inhibitors. Plos One. 7: e43171. PMID 22905224 DOI: 10.1371/journal.pone.0043171 |
0.339 |
|
| 2012 |
Dong X, Yan J, Du L, Wu P, Huang S, Liu T, Hu Y. Pharmacophore identification, docking and “in silico” screening for novel CDK1 inhibitors Journal of Molecular Graphics & Modelling. 37: 77-86. PMID 22622012 DOI: 10.1016/J.Jmgm.2012.04.003 |
0.406 |
|
| 2012 |
Wu P, Su Y, Liu X, Yang B, He Q, Hu Y. Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase α (PI3Kα) inhibitors. Bioorganic & Medicinal Chemistry. 20: 2837-44. PMID 22480851 DOI: 10.1016/J.Bmc.2012.03.026 |
0.486 |
|
| 2012 |
Wu P, Hu Y. Small molecules targeting phosphoinositide 3-kinases Medchemcomm. 3: 1337-1355. DOI: 10.1039/C2Md20044A |
0.466 |
|
| 2012 |
Wu P, Su Y, Liu X, Yan J, Ye Y, Zhang L, Xu J, Weng S, Li Y, Liu T, Dong X, Sun M, Yang B, He Q, Hu Y. Discovery of novel morpholino-quinoxalines as PI3Kα inhibitors by pharmacophore-based screening Medchemcomm. 3: 659-662. DOI: 10.1039/C2Md00255H |
0.444 |
|
| 2012 |
Huang S, Zhao Y, Zhou X, Wu Y, Wu P, Liu T, Yang B, Hu Y, Dong X. Design, synthesis and biological evaluation of 3-benzylideneflavanone derivatives as cytotoxic agents Medicinal Chemistry Research. 21: 4150-4157. DOI: 10.1007/S00044-011-9959-8 |
0.375 |
|
| 2011 |
Huang W, Tang L, Shi Y, Huang S, Xu L, Sheng R, Wu P, Li J, Zhou N, Hu Y. Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H₃R and BACE 1 inhibitory activities. Bioorganic & Medicinal Chemistry. 19: 7158-67. PMID 22019465 DOI: 10.1016/J.Bmc.2011.09.061 |
0.339 |
|
| 2011 |
Dong X, Wang Y, Liu T, Wu P, Gao J, Xu J, Yang B, Hu Y. Flavonoids as vasorelaxant agents: synthesis, biological evaluation and quantitative structure activities relationship (QSAR) studies. Molecules (Basel, Switzerland). 16: 8257-72. PMID 21959298 DOI: 10.3390/Molecules16108257 |
0.364 |
|
| 2011 |
Wu P, Su Y, Liu X, Zhang L, Ye Y, Xu J, Weng S, Li Y, Liu T, Huang S, Yang B, He Q, Hu Y. Synthesis and biological evaluation of novel 2-arylamino-3-(arylsulfonyl)quinoxalines as PI3Kα inhibitors. European Journal of Medicinal Chemistry. 46: 5540-8. PMID 21945250 DOI: 10.1016/J.Ejmech.2011.09.015 |
0.405 |
|
| 2010 |
Wu P, Hu Y. PI3K/Akt/mTOR Pathway Inhibitors in Cancer: A Perspective on Clinical Progress Current Medicinal Chemistry. 17: 4326-4341. PMID 20939811 DOI: 10.2174/092986710793361234 |
0.411 |
|
| 2010 |
Huang W, Lv D, Yu H, Sheng R, Kim SC, Wu P, Luo K, Li J, Hu Y. Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimer's disease. Bioorganic & Medicinal Chemistry. 18: 5610-5. PMID 20620068 DOI: 10.1016/J.Bmc.2010.06.042 |
0.41 |
|
| 2009 |
Wu P, Liu T, Hu Y. PI3K Inhibitors for Cancer Therapy : What has been Achieved So Far? Current Medicinal Chemistry. 16: 916-930. PMID 19275602 DOI: 10.2174/092986709787581905 |
0.4 |
|
| 2008 |
Dong X, Liu T, Yan J, Wu P, Chen J, Hu Y. Synthesis, biological evaluation and quantitative structure-activities relationship of flavonoids as vasorelaxant agents. Bioorganic & Medicinal Chemistry. 17: 716-26. PMID 19070497 DOI: 10.1016/J.Bmc.2008.11.052 |
0.346 |
|
| 2008 |
Wu P, Hu Y. Synthesis of Novel 1,4-Benzoxazine-2,3-Dicarboximides from Maleic Anhydride and Substituted Aromatic Amines Synthetic Communications. 39: 70-84. DOI: 10.1080/00397910802369638 |
0.302 |
|
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