Akinori Akaike, Ph.D. - Publications

Affiliations: 
Kyoto University, Kyōto-shi, Kyōto-fu, Japan 

199 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Nakagawa S, Izumi Y, Takada-Takatori Y, Akaike A, Kume T. Increased CCL6 expression in astrocytes and neuronal protection from neuron-astrocyte interactions. Biochemical and Biophysical Research Communications. PMID 31551151 DOI: 10.1016/j.bbrc.2019.09.030  0.32
2019 Takada-Takatori Y, Takeda Y, Imai R, Izumi Y, Akaike A, Tsuchida K, Kume T. Effects of 2'-3'-dihydroxy-4',6'-dimethoxychalcone derived from green perilla on auricle thickness in chronic contact dermatitis model mice. Journal of Pharmacological Sciences. PMID 31540843 DOI: 10.1016/j.jphs.2019.08.004  0.32
2019 Takada-Takatori Y, Tomii Y, Takemasa S, Takeda Y, Izumi Y, Akaike A, Tsuchida K, Kume T. Protective effects of 2'-3'-dihydroxy-4',6'-dimethoxychalcone derived from green perilla leaves against UV radiation-induced cell injury in human cultured keratinocytes. Biological & Pharmaceutical Bulletin. PMID 31462615 DOI: 10.1248/bpb.b19-00618  0.32
2019 Iwasaki M, Izuo N, Izumi Y, Takada-Takatori Y, Akaike A, Kume T. Protective effect of green perilla-derived chalcone derivative DDC on amyloid β protein-induced neurotoxicity in primary cortical neurons. Biological & Pharmaceutical Bulletin. PMID 31462605 DOI: 10.1248/bpb.b19-00657  0.32
2019 Takada-Takatori Y, Nakagawa S, Kimata R, Nao Y, Mizukawa Y, Urushidani T, Izumi Y, Akaike A, Tsuchida K, Kume T. Donepezil modulates amyloid precursor protein endocytosis and reduction by up-regulation of SNX33 expression in primary cortical neurons. Scientific Reports. 9: 11922. PMID 31417133 DOI: 10.1038/s41598-019-47462-4  0.32
2018 Ikeguchi S, Izumi Y, Kitamura N, Kishino S, Ogawa J, Akaike A, Kume T. Inhibitory effect of the gut microbial linoleic acid metabolites, 10-oxo-trans-11-octadecenoic acid and 10-hydroxy-cis-12-octadecenoic acid, on BV-2 microglial cell activation. Journal of Pharmacological Sciences. PMID 30243517 DOI: 10.1016/j.jphs.2018.06.015  0.32
2017 Izumi Y, Kataoka H, Inose Y, Akaike A, Koyama Y, Kume T. Neuroprotective effect of an Nrf2-ARE activator identified from a chemical library on dopaminergic neurons. European Journal of Pharmacology. PMID 29154837 DOI: 10.1016/j.ejphar.2017.11.023  0.32
2017 Okuda M, Fujita Y, Hijikuro I, Wada M, Uemura T, Kobayashi Y, Waku T, Tanaka N, Nishimoto T, Izumi Y, Kume T, Akaike A, Takahashi T, Sugimoto H. PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8. Journal of Alzheimer's Disease : Jad. PMID 28598836 DOI: 10.3233/JAD-161017  0.32
2017 Makitani K, Nakagawa S, Izumi Y, Akaike A, Kume T. Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes. Journal of Pharmacological Sciences. PMID 28499726 DOI: 10.1016/j.jphs.2017.03.008  0.32
2017 Izumi Y, Wakita S, Kanbara C, Nakai T, Akaike A, Kume T. Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons. Scientific Reports. 7: 42111. PMID 28176845 DOI: 10.1038/srep42111  0.32
2017 Yuta M, Izumi Y, Matsumura A, Akaike A, Kume T. Protective effect of Nrf2-ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson's disease model. European Journal of Pharmacology. PMID 28167258 DOI: 10.1016/j.ejphar.2017.02.005  0.32
2016 Izumi Y, Kondo N, Takahashi R, Akaike A, Kume T. Reduction of Immunoreactivity Against the C-Terminal Region of the Intracellular α-Synuclein by Exogenous α-Synuclein Aggregates: Possibility of Conformational Changes. Journal of Parkinson's Disease. PMID 27314756 DOI: 10.3233/JPD-160835  0.32
2016 Kume T, Suenaga A, Izumi Y, Akaike A. Protective Effect of Dimethyl Fumarate on an Oxidative Stress Model Induced by Sodium Nitroprusside in Mice. Biological & Pharmaceutical Bulletin. 39: 1055-9. PMID 27251510 DOI: 10.1248/bpb.b16-00134  0.32
2015 Izumi Y, Yamamoto N, Matsushima S, Yamamoto T, Takada-Takatori Y, Akaike A, Kume T. Compensatory role of the Nrf2-ARE pathway against paraquat toxicity: Relevance of 26S proteasome activity. Journal of Pharmacological Sciences. PMID 26598004 DOI: 10.1016/j.jphs.2015.09.003  0.36
2015 Fujimura K, Niidome T, Shinozuka Y, Izumi Y, Kihara T, Sugimoto H, Akaike A, Kume T. Integrin-associated protein promotes neuronal differentiation of neural stem/progenitor cells. Plos One. 10: e0116741. PMID 25706387 DOI: 10.1371/journal.pone.0116741  0.36
2014 Ioroi T, Akao M, Iguchi M, Kato M, Kimura T, Izumi Y, Akaike A, Kume T. Serofendic acid protects against myocardial ischemia-reperfusion injury in rats. Journal of Pharmacological Sciences. 126: 274-80. PMID 25367261 DOI: DN/JST.JSTAGE/jphs/14139FP  0.36
2014 Takemoto H, Omameuda Y, Ito M, Fukuda T, Kaneko S, Akaike A, Kobayashi Y. Inhalation administration of valerena-4,7(11)-diene from Nardostachys chinensis roots ameliorates restraint stress-induced changes in murine behavior and stress-related factors. Biological & Pharmaceutical Bulletin. 37: 1050-5. PMID 24882416 DOI: DN/JST.JSTAGE/bpb/b14-00136  0.36
2014 Akaike A. [Strategic construction of an innovative drug development pipeline by industry-academia cooperation - consortium for drug innovation in the Tokai region of Japan]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 143: 254-9. PMID 24813797 DOI: DN/JST.JSTAGE/fpj/143.254  0.36
2014 Izumi Y, Ezumi M, Takada-Takatori Y, Akaike A, Kume T. Endogenous dopamine is involved in the herbicide paraquat-induced dopaminergic cell death. Toxicological Sciences : An Official Journal of the Society of Toxicology. 139: 466-78. PMID 24743698 DOI: 10.1093/toxsci/kfu054  0.36
2014 Nazari QA, Takada-Takatori Y, Hashimoto T, Imaizumi A, Izumi Y, Akaike A, Kume T. Potential protective effect of highly bioavailable curcumin on an oxidative stress model induced by microinjection of sodium nitroprusside in mice brain. Food & Function. 5: 984-9. PMID 24637610 DOI: 10.1039/c4fo00009a  0.36
2014 Wakita S, Izumi Y, Nakai T, Adachi K, Takada-Takatori Y, Kume T, Akaike A. Staurosporine induces dopaminergic neurite outgrowth through AMP-activated protein kinase/mammalian target of rapamycin signaling pathway. Neuropharmacology. 77: 39-48. PMID 24067927 DOI: 10.1016/j.neuropharm.2013.09.012  0.36
2013 Ioroi T, Taguchi K, Izumi Y, Takada-Takatori Y, Akaike A, Kume T. Protective effect of serofendic acid, administered intravenously, on cerebral ischemia-reperfusion injury in rats. Brain Research. 1532: 99-105. PMID 23954678 DOI: 10.1016/j.brainres.2013.08.013  0.36
2013 Nazari QA, Kume T, Izuo N, Takada-Takatori Y, Imaizumi A, Hashimoto T, Izumi Y, Akaike A. Neuroprotective effects of curcumin and highly bioavailable curcumin on oxidative stress induced by sodium nitroprusside in rat striatal cell culture. Biological & Pharmaceutical Bulletin. 36: 1356-62. PMID 23902979 DOI: DN/JST.JSTAGE/bpb/b13-00300  0.36
2013 Izuo N, Murakami K, Sato M, Iwasaki M, Izumi Y, Shimizu T, Akaike A, Irie K, Kume T. Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease. Biochemical and Biophysical Research Communications. 438: 1-5. PMID 23747423 DOI: 10.1016/j.bbrc.2013.05.106  0.36
2013 Nazari QA, Kume T, Takada-Takatori Y, Izumi Y, Akaike A. Protective effect of luteolin on an oxidative-stress model induced by microinjection of sodium nitroprusside in mice. Journal of Pharmacological Sciences. 122: 109-17. PMID 23707972 DOI: DN/JST.JSTAGE/jphs/13019FP  0.36
2012 Izuo N, Kume T, Sato M, Murakami K, Irie K, Izumi Y, Akaike A. Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42. Acs Chemical Neuroscience. 3: 674-81. PMID 23019494 DOI: 10.1021/cn300033k  0.36
2012 Nazari QA, Mizuno K, Kume T, Takada-Takatori Y, Izumi Y, Akaike A. In vivo brain oxidative stress model induced by microinjection of sodium nitroprusside in mice. Journal of Pharmacological Sciences. 120: 105-11. PMID 23018898 DOI: DN/JST.JSTAGE/jphs/12143FP  0.36
2012 Matsuda S, Kuwako K, Okano HJ, Tsutsumi S, Aburatani H, Saga Y, Matsuzaki Y, Akaike A, Sugimoto H, Okano H. Sox21 promotes hippocampal adult neurogenesis via the transcriptional repression of the Hes5 gene. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 12543-57. PMID 22956844 DOI: 10.1523/JNEUROSCI.5803-11.2012  0.36
2012 Hongo H, Kihara T, Kume T, Izumi Y, Niidome T, Sugimoto H, Akaike A. Glycogen synthase kinase-3β activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization. Biochemical and Biophysical Research Communications. 426: 94-9. PMID 22922102 DOI: 10.1016/j.bbrc.2012.08.042  0.36
2012 Izumi Y, Matsumura A, Wakita S, Akagi K, Fukuda H, Kume T, Irie K, Takada-Takatori Y, Sugimoto H, Hashimoto T, Akaike A. Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis). Free Radical Biology & Medicine. 53: 669-79. PMID 22749808 DOI: 10.1016/j.freeradbiomed.2012.06.021  0.36
2012 Unemura K, Kume T, Kondo M, Maeda Y, Izumi Y, Akaike A. Glucocorticoids decrease astrocyte numbers by reducing glucocorticoid receptor expression in vitro and in vivo. Journal of Pharmacological Sciences. 119: 30-9. PMID 22641130 DOI: JST.JSTAGE/jphs/12047FP  0.36
2011 Kurokawa Y, Sekiguchi F, Kubo S, Yamasaki Y, Matsuda S, Okamoto Y, Sekimoto T, Fukatsu A, Nishikawa H, Kume T, Fukushima N, Akaike A, Kawabata A. Involvement of ERK in NMDA receptor-independent cortical neurotoxicity of hydrogen sulfide. Biochemical and Biophysical Research Communications. 414: 727-32. PMID 22001931 DOI: 10.1016/j.bbrc.2011.09.144  0.36
2011 Wang PL, Niidome T, Kume T, Akaike A, Kihara T, Sugimoto H. Functional and molecular interactions between Rac1 and FE65. Neuroreport. 22: 716-20. PMID 21878794 DOI: 10.1097/WNR.0b013e32834aca9d  0.36
2011 Ohnishi M, Katsuki H, Fukutomi C, Takahashi M, Motomura M, Fukunaga M, Matsuoka Y, Isohama Y, Izumi Y, Kume T, Inoue A, Akaike A. HMGB1 inhibitor glycyrrhizin attenuates intracerebral hemorrhage-induced injury in rats. Neuropharmacology. 61: 975-80. PMID 21752338 DOI: 10.1016/j.neuropharm.2011.06.026  0.36
2011 Oda T, Kume T, Izumi Y, Ishihara K, Sugmimoto H, Akaike A. Na+/Ca2+ exchanger inhibitors inhibit neurite outgrowth in PC12 cells. Journal of Pharmacological Sciences. 116: 128-31. PMID 21521931 DOI: JST.JSTAGE/jphs/11011SC  0.36
2011 Mizuno K, Kume T, Muto C, Takada-Takatori Y, Izumi Y, Sugimoto H, Akaike A. Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)--antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate. Journal of Pharmacological Sciences. 115: 320-8. PMID 21358121 DOI: JST.JSTAGE/jphs/10257FP  0.36
2011 Izumi Y, Kume T, Akaike A. [Regulation of dopaminergic neuronal death by endogenous dopamine and proteasome activity]. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan. 131: 21-7. PMID 21212609 DOI: JST.JSTAGE/yakushi/131.21  0.36
2010 Suzuki T, Murakami K, Izuo N, Kume T, Akaike A, Nagata T, Nishizaki T, Tomiyama T, Takuma H, Mori H, Irie K. E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity. International Journal of Alzheimer's Disease. 2011: 431320. PMID 21234376 DOI: 10.4061/2011/431320  0.36
2010 Nishimoto T, Matsumoto A, Kihara T, Akaike A, Sugimoto H. Protective effect of H2O2 against subsequent H2O2-induced cytotoxicity involves activation of the PI3K-Akt signaling pathway. Cellular and Molecular Biology (Noisy-Le-Grand, France). 56: OL1447-52. PMID 21215240 DOI: 10.1170/164  0.36
2010 Shen H, Kihara T, Hongo H, Wu X, Kem WR, Shimohama S, Akaike A, Niidome T, Sugimoto H. Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors. British Journal of Pharmacology. 161: 127-39. PMID 20718745 DOI: 10.1111/j.1476-5381.2010.00894.x  0.36
2010 Wu X, Kihara T, Hongo H, Akaike A, Niidome T, Sugimoto H. Angiotensin receptor type 1 antagonists protect against neuronal injury induced by oxygen-glucose depletion. British Journal of Pharmacology. 161: 33-50. PMID 20718738 DOI: 10.1111/j.1476-5381.2010.00840.x  0.36
2010 Wakita S, Izumi Y, Matsuo T, Kume T, Takada-Takatori Y, Sawada H, Akaike A. Reconstruction and quantitative evaluation of dopaminergic innervation of striatal neurons in dissociated primary cultures. Journal of Neuroscience Methods. 192: 83-9. PMID 20674606 DOI: 10.1016/j.jneumeth.2010.07.026  0.36
2010 Matsuo T, Izumi Y, Kume T, Takada-Takatori Y, Sawada H, Akaike A. Protective effect of aripiprazole against glutamate cytotoxicity in dopaminergic neurons of rat mesencephalic cultures. Neuroscience Letters. 481: 78-81. PMID 20600606 DOI: 10.1016/j.neulet.2010.06.049  0.36
2010 Ohnishi M, Katsuki H, Unemura K, Izumi Y, Kume T, Takada-Takatori Y, Akaike A. Heme oxygenase-1 contributes to pathology associated with thrombin-induced striatal and cortical injury in organotypic slice culture. Brain Research. 1347: 170-8. PMID 20515663 DOI: 10.1016/j.brainres.2010.05.077  0.36
2010 Matsuo T, Izumi Y, Wakita S, Kume T, Takada-Takatori Y, Sawada H, Akaike A. Haloperidol, spiperone, pimozide and aripiprazole reduce intracellular dopamine content in PC12 cells and rat mesencephalic cultures: Implication of inhibition of vesicular transport. European Journal of Pharmacology. 640: 68-74. PMID 20460122 DOI: 10.1016/j.ejphar.2010.04.043  0.36
2010 Akaike A, Kume T, Izumi Y, Osakada F. [Factors regulating regeneration and differentiation of the retina]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 135: 142-5. PMID 20410655 DOI: JST.JSTAGE/fpj/135.142  0.36
2010 Katsuki H, Kurosu S, Michinaga S, Hisatsune A, Isohama Y, Izumi Y, Kume T, Akaike A. Depolarizing stimuli cause persistent and selective loss of orexin in rat hypothalamic slice culture. Peptides. 31: 1131-8. PMID 20307612 DOI: 10.1016/j.peptides.2010.03.006  0.36
2010 Ohnishi M, Katsuki H, Izumi Y, Kume T, Takada-Takatori Y, Akaike A. Mitogen-activated protein kinases support survival of activated microglia that mediate thrombin-induced striatal injury in organotypic slice culture. Journal of Neuroscience Research. 88: 2155-64. PMID 20175209 DOI: 10.1002/jnr.22375  0.36
2010 Takada-Takatori Y, Kume T, Izumi Y, Niidome T, Fujii T, Sugimoto H, Akaike A. Mechanisms of chronic nicotine treatment-induced enhancement of the sensitivity of cortical neurons to the neuroprotective effect of donepezil in cortical neurons. Journal of Pharmacological Sciences. 112: 265-72. PMID 20173312 DOI: JST.JSTAGE/jphs/09311FP  0.36
2010 Kihara T, Shimmyo Y, Akaike A, Niidome T, Sugimoto H. Abeta-induced BACE-1 cleaves N-terminal sequence of mPGES-2. Biochemical and Biophysical Research Communications. 393: 728-33. PMID 20171164 DOI: 10.1016/j.bbrc.2010.02.069  0.36
2010 Sagane K, Sugimoto H, Akaike A. Biological characterization of ADAM22 variants reveals the importance of a disintegrin domain sequence in cell surface expression. Journal of Receptor and Signal Transduction Research. 30: 72-7. PMID 20156119 DOI: 10.3109/10799891003614790  0.36
2010 Yamamoto N, Izumi Y, Matsuo T, Wakita S, Kume T, Takada-Takatori Y, Sawada H, Akaike A. Elevation of heme oxygenase-1 by proteasome inhibition affords dopaminergic neuroprotection. Journal of Neuroscience Research. 88: 1934-42. PMID 20155807 DOI: 10.1002/jnr.22363  0.36
2010 Wu X, Kihara T, Akaike A, Niidome T, Sugimoto H. PI3K/Akt/mTOR signaling regulates glutamate transporter 1 in astrocytes. Biochemical and Biophysical Research Communications. 393: 514-8. PMID 20152809 DOI: 10.1016/j.bbrc.2010.02.038  0.36
2010 Takahashi J, Hijikuro I, Kihara T, Murugesh MG, Fuse S, Tsumura Y, Akaike A, Niidome T, Takahashi T, Sugimoto H. Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 1721-3. PMID 20137941 DOI: 10.1016/j.bmcl.2010.01.035  0.36
2010 Takahashi J, Hijikuro I, Kihara T, Murugesh MG, Fuse S, Kunimoto R, Tsumura Y, Akaike A, Niidome T, Okuno Y, Takahashi T, Sugimoto H. Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 1718-20. PMID 20137934 DOI: 10.1016/j.bmcl.2010.01.057  0.36
2010 Yamakawa K, Izumi Y, Takeuchi H, Yamamoto N, Kume T, Akaike A, Takahashi R, Shimohama S, Sawada H. Dopamine facilitates alpha-synuclein oligomerization in human neuroblastoma SH-SY5Y cells. Biochemical and Biophysical Research Communications. 391: 129-34. PMID 19900407 DOI: 10.1016/j.bbrc.2009.11.015  0.36
2010 Akaike A, Takada-Takatori Y, Kume T, Izumi Y. Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. Journal of Molecular Neuroscience : Mn. 40: 211-6. PMID 19714494 DOI: 10.1007/s12031-009-9236-1  0.36
2009 Niidome T, Nonaka H, Akaike A, Kihara T, Sugimoto H. Basic fibroblast growth factor promotes the generation of microtubule-associated protein 2-positive cells from microglia. Biochemical and Biophysical Research Communications. 390: 1018-22. PMID 19854155 DOI: 10.1016/j.bbrc.2009.10.100  0.36
2009 Hama Y, Katsuki H, Izumi Y, Kume T, Akaike A. Excitotoxicity-associated p53 expression in adult rat retina is mediated by calpain activity but not by Cl- influx. Journal of Pharmacological Sciences. 110: 493-6. PMID 19652454 DOI: JST.JSTAGE/jphs/09105SC  0.36
2009 Niidome T, Goto Y, Kato M, Wang PL, Goh S, Tanaka N, Akaike A, Kihara T, Sugimoto H. Non-fibrillar amyloid-beta peptide reduces NMDA-induced neurotoxicity, but not AMPA-induced neurotoxicity. Biochemical and Biophysical Research Communications. 386: 734-8. PMID 19563781 DOI: 10.1016/j.bbrc.2009.06.130  0.36
2009 Kita A, Kinoshita T, Kohayakawa H, Furukawa K, Akaike A. Lack of tolerance to anxiolysis and withdrawal symptoms in mice repeatedly treated with AC-5216, a selective TSPO ligand. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 33: 1040-5. PMID 19497344 DOI: 10.1016/j.pnpbp.2009.05.018  0.36
2009 Takahashi K, Niidome T, Akaike A, Kihara T, Sugimoto H. Amyloid precursor protein promotes endoplasmic reticulum stress-induced cell death via C/EBP homologous protein-mediated pathway. Journal of Neurochemistry. 109: 1324-37. PMID 19476545 DOI: 10.1111/j.1471-4159.2009.06067.x  0.36
2009 Katsuki H, Kurimoto E, Takemori S, Kurauchi Y, Hisatsune A, Isohama Y, Izumi Y, Kume T, Shudo K, Akaike A. Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling. Journal of Neurochemistry. 110: 707-18. PMID 19457078 DOI: 10.1111/j.1471-4159.2009.06171.x  0.36
2009 Izumi Y, Yamamoto N, Matsuo T, Wakita S, Takeuchi H, Kume T, Katsuki H, Sawada H, Akaike A. Vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and MAPK activation. Journal of Neurochemistry. 110: 745-55. PMID 19457068 DOI: 10.1111/j.1471-4159.2009.06178.x  0.36
2009 Kubota Y, Yano Y, Morimoto T, Seki S, Takada K, Kuramoto N, Maeda Y, Akaike A, Hiraide A. Reliability of evaluation for communication competency in pharmaceutical objective structured clinical examination (OSCE). Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan. 129: 609-16. PMID 19420892 DOI: JST.JSTAGE/yakushi/129.609  0.36
2009 Wang PL, Niidome T, Akaike A, Kihara T, Sugimoto H. Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene. Journal of Neuroscience Research. 87: 2105-14. PMID 19267423 DOI: 10.1002/jnr.22039  0.36
2009 Takada-Takatori Y, Kume T, Izumi Y, Ohgi Y, Niidome T, Fujii T, Sugimoto H, Akaike A. Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation. Biological & Pharmaceutical Bulletin. 32: 318-24. PMID 19252271 DOI: JST.JSTAGE/bpb/32.318  0.36
2009 Akaike A. Functional changes induced by long-term stimulation of nicotinic acetylcholine receptors. Foreword. Biological & Pharmaceutical Bulletin. 32: 317. PMID 19252270 DOI: JST.JSTAGE/bpb/32.317  0.36
2009 Nonaka H, Niidome T, Shinozuka Y, Akaike A, Kihara T, Sugimoto H. A role for SOX2 in the generation of microtubule-associated protein 2-positive cells from microglia. Biochemical and Biophysical Research Communications. 380: 60-4. PMID 19161985 DOI: 10.1016/j.bbrc.2009.01.027  0.36
2009 Nishimoto T, Kihara T, Akaike A, Niidome T, Sugimoto H. AMPA reduces surface expression of NR1 through regulation of GSK3beta. Neuroreport. 20: 161-5. PMID 19151600 DOI: 10.1097/WNR.0b013e3283118450  0.36
2009 Kume T, Ito R, Taguchi R, Izumi Y, Katsuki H, Niidome T, Takada-Takatori Y, Sugimoto H, Akaike A. Serofendic acid promotes stellation induced by cAMP and cGMP analogs in cultured cortical astrocytes. Journal of Pharmacological Sciences. 109: 110-8. PMID 19122367 DOI: JST.JSTAGE/jphs/08254FP  0.36
2009 Ohnishi M, Katsuki H, Takagi M, Kume T, Akaike A. Long-term treatment with nicotine suppresses neurotoxicity of, and microglial activation by, thrombin in cortico-striatal slice cultures. European Journal of Pharmacology. 602: 288-93. PMID 19063881 DOI: 10.1016/j.ejphar.2008.11.041  0.36
2009 Kitamura O, Uemura K, Kitamura H, Sugimoto H, Akaike A, Ono T. Serofendic acid protects from iodinated contrast medium and high glucose probably against superoxide production in LLC-PK1 cells. Clinical and Experimental Nephrology. 13: 15-24. PMID 18827965 DOI: 10.1007/s10157-008-0081-2  0.36
2009 Takeuchi H, Yanagida T, Inden M, Takata K, Kitamura Y, Yamakawa K, Sawada H, Izumi Y, Yamamoto N, Kihara T, Uemura K, Inoue H, Taniguchi T, Akaike A, Takahashi R, et al. Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models. Journal of Neuroscience Research. 87: 576-85. PMID 18803299 DOI: 10.1002/jnr.21869  0.36
2009 Herng TS, Lau SP, Wang L, Zhao BC, Yu SF, Tanemura M, Akaike A, Teng KS. Magnetotransport properties of p -type carbon-doped ZnO thin films Applied Physics Letters. 95. DOI: 10.1063/1.3176434  0.36
2008 Takahashi K, Niidome T, Akaike A, Kihara T, Sugimoto H. Phosphorylation of amyloid precursor protein (APP) at Tyr687 regulates APP processing by alpha- and gamma-secretase. Biochemical and Biophysical Research Communications. 377: 544-9. PMID 18854169 DOI: 10.1016/j.bbrc.2008.10.013  0.36
2008 Oda T, Kume T, Izumi Y, Takada-Takatori Y, Niidome T, Akaike A. Bromocriptine, a dopamine D(2) receptor agonist with the structure of the amino acid ergot alkaloids, induces neurite outgrowth in PC12 cells. European Journal of Pharmacology. 598: 27-31. PMID 18835264 DOI: 10.1016/j.ejphar.2008.09.015  0.36
2008 Niidome T, Taniuchi N, Akaike A, Kihara T, Sugimoto H. Differential regulation of neurogenesis in two neurogenic regions of APPswe/PS1dE9 transgenic mice. Neuroreport. 19: 1361-4. PMID 18766011 DOI: 10.1097/WNR.0b013e32830e6dd6  0.36
2008 Shimmyo Y, Kihara T, Akaike A, Niidome T, Sugimoto H. Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation. Neuroreport. 19: 1329-33. PMID 18695518 DOI: 10.1097/WNR.0b013e32830b8ae1  0.36
2008 Kume T, Kawato Y, Osakada F, Izumi Y, Katsuki H, Nakagawa T, Kaneko S, Niidome T, Takada-Takatori Y, Akaike A. Dibutyryl cyclic AMP induces differentiation of human neuroblastoma SH-SY5Y cells into a noradrenergic phenotype. Neuroscience Letters. 443: 199-203. PMID 18691633 DOI: 10.1016/j.neulet.2008.07.079  0.36
2008 Takada-Takatori Y, Kume T, Ohgi Y, Izumi Y, Niidome T, Fujii T, Sugimoto H, Akaike A. Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil. Journal of Neuroscience Research. 86: 3575-83. PMID 18655200 DOI: 10.1002/jnr.21798  0.36
2008 Hama Y, Katsuki H, Suminaka C, Kume T, Akaike A. Chloride-dependent acute excitotoxicity in adult rat retinal ganglion cells. Neuropharmacology. 55: 677-86. PMID 18586043 DOI: 10.1016/j.neuropharm.2008.06.006  0.36
2008 Takada-Takatori Y, Kume T, Ohgi Y, Fujii T, Niidome T, Sugimoto H, Akaike A. Mechanisms of alpha7-nicotinic receptor up-regulation and sensitization to donepezil induced by chronic donepezil treatment. European Journal of Pharmacology. 590: 150-6. PMID 18585378 DOI: 10.1016/j.ejphar.2008.06.027  0.36
2008 Akasofu S, Sawada K, Kosasa T, Hihara H, Ogura H, Akaike A. Donepezil attenuates excitotoxic damage induced by membrane depolarization of cortical neurons exposed to veratridine. European Journal of Pharmacology. 588: 189-97. PMID 18508044 DOI: 10.1016/j.ejphar.2008.03.064  0.36
2008 Nakamura T, Kume T, Katsuki H, Niidome T, Sugimoto H, Akaike A. Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats. European Journal of Pharmacology. 586: 151-5. PMID 18423598 DOI: 10.1016/j.ejphar.2008.02.079  0.36
2008 Niidome T, Matsuda S, Nonaka H, Akaike A, Kihara T, Sugimoto H. A molecular pathway involved in the generation of microtubule-associated protein 2-positive cells from microglia. Biochemical and Biophysical Research Communications. 370: 184-8. PMID 18361915 DOI: 10.1016/j.bbrc.2008.03.068  0.36
2008 Shimmyo Y, Kihara T, Akaike A, Niidome T, Sugimoto H. Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features. Biochimica Et Biophysica Acta. 1780: 819-25. PMID 18295609 DOI: 10.1016/j.bbagen.2008.01.017  0.36
2008 Matsuda S, Niidome T, Nonaka H, Goto Y, Fujimura K, Kato M, Nakanishi M, Akaike A, Kihara T, Sugimoto H. Microtubule-associated protein 2-positive cells derived from microglia possess properties of functional neurons. Biochemical and Biophysical Research Communications. 368: 971-6. PMID 18284917 DOI: 10.1016/j.bbrc.2008.02.038  0.36
2008 Goto Y, Niidome T, Hongo H, Akaike A, Kihara T, Sugimoto H. Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease. European Journal of Pharmacology. 583: 84-91. PMID 18282567 DOI: 10.1016/j.ejphar.2008.01.030  0.36
2008 Shimmyo Y, Kihara T, Akaike A, Niidome T, Sugimoto H. Three distinct neuroprotective functions of myricetin against glutamate-induced neuronal cell death: involvement of direct inhibition of caspase-3. Journal of Neuroscience Research. 86: 1836-45. PMID 18265412 DOI: 10.1002/jnr.21629  0.36
2008 Izumi Y, Yamamoto N, Kume T, Katsuki H, Sawada H, Akaike A. Regulation of intracellular dopamine levels by dopaminergic drugs: involvement of vesicular monoamine transporter. European Journal of Pharmacology. 582: 52-61. PMID 18261722 DOI: 10.1016/j.ejphar.2007.12.015  0.36
2008 Osakada F, Ikeda H, Mandai M, Wataya T, Watanabe K, Yoshimura N, Akaike A, Akaike A, Sasai Y, Takahashi M. Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nature Biotechnology. 26: 215-24. PMID 18246062 DOI: 10.1038/nbt1384  0.52
2008 Nishimoto T, Kihara T, Akaike A, Niidome T, Sugimoto H. alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionate attenuates glutamate-induced caspase-3 cleavage via regulation of glycogen synthase kinase 3beta. Journal of Neuroscience Research. 86: 1096-105. PMID 18041091 DOI: 10.1002/jnr.21567  0.36
2008 Fujimoto S, Katsuki H, Ohnishi M, Takagi M, Kume T, Akaike A. Plasminogen potentiates thrombin cytotoxicity and contributes to pathology of intracerebral hemorrhage in rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 506-15. PMID 17940541 DOI: 10.1038/sj.jcbfm.9600547  0.36
2008 Yanagisawa D, Kitamura Y, Inden M, Takata K, Taniguchi T, Morikawa S, Morita M, Inubushi T, Tooyama I, Taira T, Iguchi-Ariga SM, Akaike A, Ariga H. DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 563-78. PMID 17882163 DOI: 10.1038/sj.jcbfm.9600553  0.36
2008 Shimmyo Y, Kihara T, Akaike A, Niidome T, Sugimoto H. Multifunction of myricetin on A beta: neuroprotection via a conformational change of A beta and reduction of A beta via the interference of secretases. Journal of Neuroscience Research. 86: 368-77. PMID 17722071 DOI: 10.1002/jnr.21476  0.36
2008 Osakada F, Ikeda H, Mandai M, Wataya T, Watanabe K, Yoshimura N, Akaike A, Sasai Y, Takahashi M. Corrigendum: Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells (Nature Biotechnology (2008) 26, (215-224)) Nature Biotechnology. 26: 352. DOI: 10.1038/nbt0308-352b  0.52
2007 Taniuchi N, Niidome T, Goto Y, Akaike A, Kihara T, Sugimoto H. Decreased proliferation of hippocampal progenitor cells in APPswe/PS1dE9 transgenic mice. Neuroreport. 18: 1801-5. PMID 18090315 DOI: 10.1097/WNR.0b013e3282f1c9e9  0.36
2007 Akao M, Takeda T, Kita T, Kume T, Akaike A. Serofendic acid, a substance extracted from fetal calf serum, as a novel drug for cardioprotection. Cardiovascular Drug Reviews. 25: 333-41. PMID 18078433 DOI: 10.1111/j.1527-3466.2007.00026.x  0.36
2007 Terauchi T, Asai N, Doko T, Taguchi R, Takenaka O, Sakurai H, Yonaga M, Kimura T, Kajiwara A, Niidome T, Kume T, Akaike A, Sugimoto H. Synthesis and pharmacological profile of serofendic acids A and B. Bioorganic & Medicinal Chemistry. 15: 7098-107. PMID 17804246 DOI: 10.1016/j.bmc.2007.07.037  0.36
2007 Katsuki H, Watanabe Y, Fujimoto S, Kume T, Akaike A. Contribution of endogenous glycine and d-serine to excitotoxic and ischemic cell death in rat cerebrocortical slice cultures. Life Sciences. 81: 740-9. PMID 17698151 DOI: 10.1016/j.lfs.2007.07.001  0.36
2007 Oda T, Kume T, Katsuki H, Niidome T, Sugimoto H, Akaike A. Donepezil potentiates nerve growth factor-induced neurite outgrowth in PC12 cells. Journal of Pharmacological Sciences. 104: 349-54. PMID 17675796 DOI: JST.JSTAGE/jphs/FP0070563  0.36
2007 Ohnishi M, Katsuki H, Fujimoto S, Takagi M, Kume T, Akaike A. Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury. Experimental Neurology. 206: 43-52. PMID 17498698 DOI: 10.1016/j.expneurol.2007.03.030  0.36
2007 Niidome T, Takahashi K, Goto Y, Goh S, Tanaka N, Kamei K, Ichida M, Hara S, Akaike A, Kihara T, Sugimoto H. Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity. Neuroreport. 18: 813-6. PMID 17471072 DOI: 10.1097/WNR.0b013e3280dce5af  0.36
2007 Osakada F, Ooto S, Akagi T, Mandai M, Akaike A, Takahashi M. Wnt signaling promotes regeneration in the retina of adult mammals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4210-9. PMID 17428999 DOI: 10.1523/JNEUROSCI.4193-06.2007  0.36
2007 Nakanishi M, Niidome T, Matsuda S, Akaike A, Kihara T, Sugimoto H. Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells. The European Journal of Neuroscience. 25: 649-58. PMID 17328769 DOI: 10.1111/j.1460-9568.2007.05309.x  0.36
2007 Izumi Y, Sawada H, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A. Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity. European Journal of Pharmacology. 557: 132-40. PMID 17161393 DOI: 10.1016/j.ejphar.2006.11.011  0.36
2007 Yamamoto N, Sawada H, Izumi Y, Kume T, Katsuki H, Shimohama S, Akaike A. Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease. The Journal of Biological Chemistry. 282: 4364-72. PMID 17158454 DOI: 10.1074/jbc.M603712200  0.36
2007 Okawara M, Katsuki H, Kurimoto E, Shibata H, Kume T, Akaike A. Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. Biochemical Pharmacology. 73: 550-60. PMID 17147953 DOI: 10.1016/j.bcp.2006.11.003  0.36
2007 Fujimoto S, Katsuki H, Ohnishi M, Takagi M, Kume T, Akaike A. Thrombin induces striatal neurotoxicity depending on mitogen-activated protein kinase pathways in vivo Neuroscience. 144: 694-701. PMID 17084034 DOI: 10.1016/j.neuroscience.2006.09.049  0.36
2007 Katsuki H, Akaike A. Brain slice preparation for evaluation of the pathophysiological functions of D-Serine D-Amino Acids: a New Frontier in Amino Acid and Protein Research - Practical Methods and Protocols. 181-186.  0.36
2006 Sawada H, Yamakawa K, Shimohama S, Takahashi R, Akaike A, Kitamura Y, Taniguchi T. [Lewy bodies: neuroprotective?]. Rinshō Shinkeigaku = Clinical Neurology. 46: 893. PMID 17432212  0.36
2006 Goto Y, Niidome T, Akaike A, Kihara T, Sugimoto H. Amyloid beta-peptide preconditioning reduces glutamate-induced neurotoxicity by promoting endocytosis of NMDA receptor. Biochemical and Biophysical Research Communications. 351: 259-65. PMID 17054909 DOI: 10.1016/j.bbrc.2006.10.030  0.36
2006 Takada-Takatori Y, Kume T, Sugimoto M, Katsuki H, Niidome T, Sugimoto H, Fujii T, Okabe S, Akaike A. Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity. European Journal of Pharmacology. 549: 19-26. PMID 16996497 DOI: 10.1016/j.ejphar.2006.08.017  0.36
2006 Niidome T, Morimoto N, Iijima S, Akaike A, Kihara T, Sugimoto H. Mechanisms of cell death of neural progenitor cells caused by trophic support deprivation. European Journal of Pharmacology. 548: 1-8. PMID 16965769 DOI: 10.1016/j.ejphar.2006.07.052  0.36
2006 Yanagisawa D, Qi M, Kim DH, Kitamura Y, Inden M, Tsuchiya D, Takata K, Taniguchi T, Yoshimoto K, Shimohama S, Akaike A, Sumi S, Inoue K. Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells. Neuroscience Letters. 407: 74-9. PMID 16959414 DOI: 10.1016/j.neulet.2006.08.007  0.36
2006 Hama Y, Katsuki H, Tochikawa Y, Suminaka C, Kume T, Akaike A. Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo. Neuroscience Research. 56: 279-85. PMID 16934894 DOI: 10.1016/j.neures.2006.07.008  0.36
2006 Terauchi T, Doko T, Yonaga M, Kajiwara A, Niidome T, Taguchi R, Kume T, Akaike A, Sugimoto H. Synthesis and neuroprotective effects of serofendic acid analogues. Bioorganic & Medicinal Chemistry Letters. 16: 5080-3. PMID 16904319 DOI: 10.1016/j.bmcl.2006.07.038  0.36
2006 Kume T, Taguchi R, Katsuki H, Akao M, Sugimoto H, Kaneko S, Akaike A. Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation. European Journal of Pharmacology. 542: 69-76. PMID 16806165 DOI: 10.1016/j.ejphar.2006.04.038  0.36
2006 Akaike A. Preclinical evidence of neuroprotection by cholinesterase inhibitors. Alzheimer Disease and Associated Disorders. 20: S8-11. PMID 16772755 DOI: 10.1097/01.wad.0000213802.74434.d6  0.36
2006 Takada-Takatori Y, Kume T, Sugimoto M, Katsuki H, Sugimoto H, Akaike A. Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade. Neuropharmacology. 51: 474-86. PMID 16762377 DOI: 10.1016/j.neuropharm.2006.04.007  0.36
2006 Takeda T, Akao M, Matsumoto-Ida M, Kato M, Takenaka H, Kihara Y, Kume T, Akaike A, Kita T. Serofendic acid, a novel substance extracted from fetal calf serum, protects against oxidative stress in neonatal rat cardiac myocytes. Journal of the American College of Cardiology. 47: 1882-90. PMID 16682316 DOI: 10.1016/j.jacc.2005.12.055  0.36
2006 Kaneko S, Kawakami S, Hara Y, Wakamori M, Itoh E, Minami T, Takada Y, Kume T, Katsuki H, Mori Y, Akaike A. A critical role of TRPM2 in neuronal cell death by hydrogen peroxide Journal of Pharmacological Sciences. 101: 66-76. PMID 16651700 DOI: 10.1254/jphs.FP0060128  0.36
2006 Katsuki H, Okawara M, Shibata H, Kume T, Akaike A. Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture Journal of Neurochemistry. 97: 1232-1242. PMID 16638023 DOI: 10.1111/j.1471-4159.2006.03752.x  0.36
2006 Taguchi R, Shirakawa H, Yamaguchi T, Kume T, Katsuki H, Akaike A. Nitric oxide-mediated effect of nipradilol, an α- and β-adrenergic blocker, on glutamate neurotoxicity in rat cortical cultures European Journal of Pharmacology. 535: 86-94. PMID 16516884 DOI: 10.1016/j.ejphar.2006.01.036  0.36
2006 Shirakawa H, Katsuki H, Kume T, Kaneko S, Akaike A. Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons British Journal of Pharmacology. 147: 729-736. PMID 16474421 DOI: 10.1038/sj.bjp.0706636  0.36
2006 Fujimoto S, Katsuki H, Kume T, Akaike A. Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures Neurobiology of Disease. 22: 130-142. PMID 16330215 DOI: 10.1016/j.nbd.2005.10.008  0.36
2006 Shibata H, Katsuki H, Okawara M, Kume T, Akaike A. C-Jun N-terminal kinase inhibition and α-tocopherol protect midbrain dopaminergic neurons from interferon-γ/lipopolysaccharide-induced injury without affecting nitric oxide production Journal of Neuroscience Research. 83: 102-109. PMID 16307444 DOI: 10.1002/jnr.20700  0.36
2006 Nakatsu Y, Kotake Y, Komasaka K, Hakozaki H, Taguchi R, Kume T, Akaike A, Ohta S. Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons. Toxicological Sciences : An Official Journal of the Society of Toxicology. 89: 235-42. PMID 16207939 DOI: 10.1093/toxsci/kfj007  0.36
2006 Takahata K, Shimazu S, Katsuki H, Yoneda F, Akaike A. Effects of selegiline on antioxidant systems in the nigrostriatum in rat Journal of Neural Transmission. 113: 151-158. PMID 15959853 DOI: 10.1007/s00702-005-0309-1  0.36
2006 Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M, Takeda M. Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease Psychogeriatrics. 6: S57-S63. DOI: 10.1111/j.1479-8301.2006.00172.x  0.36
2006 Akaike A, Katsuki H, Kume T, Takada-Takatori Y. Neuroprotective action of donepezil mediated by neuronal nicotinic receptors Psychogeriatrics. 6: S47-S56. DOI: 10.1111/j.1479-8301.2006.00171.x  0.36
2005 Kume T, Sugimoto M, Takada Y, Yamaguchi T, Yonezawa A, Katsuki H, Sugimoto H, Akaike A. Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons European Journal of Pharmacology. 527: 77-85. PMID 16313899 DOI: 10.1016/j.ejphar.2005.10.028  0.36
2005 Akaike A, Katsuki H, Kume T. Endogenous factors regulating neuronal apoptosis Japanese Journal of Neuropsychopharmacology. 25: 245-250. PMID 16313102  0.36
2005 Inden M, Kitamura Y, Kondo J, Hayashi K, Yanagida T, Takata K, Tsuchiya D, Yanagisawa D, Nishimura K, Taniguchi T, Shimohama S, Sugimoto H, Akaike A. Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats. Journal of Neurochemistry. 95: 950-61. PMID 16135081 DOI: 10.1111/j.1471-4159.2005.03413.x  0.36
2005 Izumi Y, Sawada H, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A. Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells. Journal of Neuroscience Research. 82: 126-37. PMID 16108071 DOI: 10.1002/jnr.20595  0.36
2005 Hirami C, Takahata K, Shimazu S, Yoneda F, Hayashi K, Katsuki H, Akaike A. Effects of R-(-)-BPAP on the expressions of neurotrophins and their receptors in mesencephalic slices Biological and Pharmaceutical Bulletin. 28: 1524-1526. PMID 16079507 DOI: 10.1248/bpb.28.1524  0.36
2005 Katsuki H, Akaike A. Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation Neuroreport. 16: 1157-1161. PMID 16012340 DOI: 10.1097/00001756-200508010-00005  0.36
2005 Kume T, Kawai Y, Yoshida K, Nakamizo T, Kanki R, Sawada H, Katsuki H, Shimohama S, Sugimoto H, Akaike A. Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons. Neuroscience Letters. 383: 199-202. PMID 15955411 DOI: 10.1016/j.neulet.2005.04.015  0.36
2005 Shirakawa H, Katsuki H, Kume T, Kaneko S, Akaike A. Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons European Journal of Neuroscience. 21: 2329-2335. PMID 15932592 DOI: 10.1111/j.1460-9568.2005.04079.x  0.36
2005 Kita T, Nakagawa T, Kim TS, Iwai K, Takebayashi S, Akaike A, Ito J. Serofendic acid promotes survival of auditory hair cells and neurons of mice. Neuroreport. 16: 689-92. PMID 15858407 DOI: 10.1097/00001756-200505120-00007  0.36
2005 Nakamizo T, Kawamata J, Yamashita H, Kanki R, Kihara T, Sawada H, Akaike A, Shimohama S. Stimulation of nicotinic acetylcholine receptors protects motor neurons. Biochemical and Biophysical Research Communications. 330: 1285-9. PMID 15823582 DOI: 10.1016/j.bbrc.2005.03.115  0.36
2005 Izumi Y, Sawada H, Sakka N, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A. p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly. Journal of Neuroscience Research. 79: 849-60. PMID 15712215 DOI: 10.1002/jnr.20382  0.36
2005 Katsuki H, Shinohara A, Fujimoto S, Kume T, Akaike A. Tetraethylammonium exacerbates ischemic neuronal injury in rat cerebrocortical slice cultures European Journal of Pharmacology. 508: 85-91. PMID 15680257 DOI: 10.1016/j.ejphar.2004.11.058  0.36
2004 Osakada F, Hashino A, Kume T, Katsuki H, Kaneko S, Akaike A. Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology. 47: 904-15. PMID 15527824 DOI: 10.1016/j.neuropharm.2004.06.029  0.36
2004 Fujimoto S, Katsuki H, Kume T, Kaneko S, Akaike A. Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures Neuroscience Research. 50: 179-187. PMID 15380325 DOI: 10.1016/j.neures.2004.06.013  0.36
2004 Inden M, Kim D, Gu Y, Kitamura Y, Kondo J, Tsuchiya D, Taniguchi T, Shimohama S, Akaike A, Sumi S, Inoue K. Pharmacological characteristics of rotational behavior in hemiparkinsonian rats transplanted with mouse embryonic stem cell-derived neurons. Journal of Pharmacological Sciences. 96: 53-64. PMID 15351793 DOI: JST.JSTAGE/jphs/FPJ04010X  0.36
2004 Kume T, Katsuki H, Akaike A. Endogenous factors regulating neuronal death induced by radical stress Biological and Pharmaceutical Bulletin. 27: 964-967. PMID 15256723 DOI: 10.1248/bpb.27.964  0.36
2004 Katsuki H, Nonaka M, Shirakawa H, Kume T, Akaike A. Endogenous D-serine is involved in induction of neuronal death by N-methyl-D-aspartate and simulated ischemia in rat cerebrocortical slices Journal of Pharmacology and Experimental Therapeutics. 311: 836-844. PMID 15240826 DOI: 10.1124/jpet.104.070912  0.36
2004 Kanki R, Nakamizo T, Yamashita H, Kihara T, Sawada H, Uemura K, Kawamata J, Shibasaki H, Akaike A, Shimohama S. Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons. Brain Research. 1015: 73-81. PMID 15223368 DOI: 10.1016/j.brainres.2004.04.044  0.36
2004 Osakada F, Kawato Y, Kume T, Katsuki H, Sugimoto H, Akaike A. Serofendic acid, a sulfur-containing diterpenoid derived from fetal calf serum, attenuates reactive oxygen species-induced oxidative stress in cultured striatal neurons. The Journal of Pharmacology and Experimental Therapeutics. 311: 51-9. PMID 15159446 DOI: 10.1124/jpet.104.070334  0.36
2004 Katsuki H, Akaike A. Excitotoxic degeneration of hypothalamic orexin neurons in slice culture Neurobiology of Disease. 15: 61-69. PMID 14751771 DOI: 10.1016/j.nbd.2003.09.003  0.36
2004 Katsuki H, Yamamoto R, Nakata D, Kume T, Akaike A. Neuronal Nitric Oxide Synthase Is Crucial for Ganglion Cell Death in Rat Retinal Explant Cultures Journal of Pharmacological Sciences. 94: 77-80. PMID 14745122 DOI: 10.1254/jphs.94.77  0.36
2004 Sawada H, Kohno R, Kihara T, Izumi Y, Sakka N, Ibi M, Nakanishi M, Nakamizo T, Yamakawa K, Shibasaki H, Yamamoto N, Akaike A, Inden M, Kitamura Y, Taniguchi T, et al. Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions. The Journal of Biological Chemistry. 279: 10710-9. PMID 14672949 DOI: 10.1074/jbc.M308434200  0.36
2003 Sakka N, Sawada H, Izumi Y, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A. Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone. Neuroreport. 14: 2425-8. PMID 14663204 DOI: 10.1097/01.wnr.0000099604.19426.06  0.36
2003 Shimazu S, Tsunekawa H, Yoneda F, Katsuki H, Akaike A, Janowsky A. Transporter-mediated actions of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane. European Journal of Pharmacology. 482: 9-16. PMID 14659999 DOI: 10.1016/j.ejphar.2003.09.044  0.36
2003 Akaike A, Katsuki H, Kume T. Pharmacological and physiological properties of serofendic acid, a novel neuroprotective substance isolated from fetal calf serum Life Sciences. 74: 263-269. PMID 14607254 DOI: 10.1016/j.lfs.2003.09.013  0.36
2003 Taguchi R, Nishikawa H, Kume T, Terauchi T, Kaneko S, Katsuki H, Yonaga M, Sugimoto H, Akaike A. Serofendic acid prevents acute glutamate neurotoxicity in cultured cortical neurons European Journal of Pharmacology. 477: 195-203. PMID 14522357 DOI: 10.1016/j.ejphar.2003.08.027  0.36
2003 Takahata K, Katsuki H, Kume T, Ito K, Tochikawa Y, Muraoka S, Yoneda F, Kashii S, Honda Y, Akaike A. Retinal neurotoxicity of nitric oxide donors with different half-life of nitric oxide release: Involvement of N-methyl-D-aspartate receptor Journal of Pharmacological Sciences. 92: 428-432. PMID 12939529  0.36
2003 Shibata H, Katsuki H, Nishiwaki M, Kume T, Kaneko S, Akaike A. Lipopolysaccharide-induced dopaminergic cell death in rat midbrain slice cultures: Role of inducible nitric oxide synthase and protection by indomethacin Journal of Neurochemistry. 86: 1201-1212. PMID 12911628  0.36
2003 Yamauchi T, Kashii S, Yasuyoshi H, Zhang S, Honda Y, Ujihara H, Akaike A. Inhibition of glutamate-induced nitric oxide synthase activation by dopamine in cultured rat retinal neurons Neuroscience Letters. 347: 155-158. PMID 12875909 DOI: 10.1016/S0304-3940(03)00669-4  0.36
2003 Yamauchi T, Kashii S, Yasuyoshi H, Zhang S, Honda Y, Akaike A. Mitochondrial ATP-sensitive potassium channel: A novel site for neuroprotection Investigative Ophthalmology and Visual Science. 44: 2750-2756. PMID 12766083 DOI: 10.1167/iovs.02-0815  0.36
2003 Kitamura Y, Taniguchi T, Shimohama S, Akaike A, Nomura Y. Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists. Neurochemical Research. 28: 1035-40. PMID 12737528 DOI: 10.1023/A:1023207222944  0.36
2003 Takada Y, Yonezawa A, Kume T, Katsuki H, Kaneko S, Sugimoto H, Akaike A. Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons Journal of Pharmacology and Experimental Therapeutics. 306: 772-777. PMID 12734391 DOI: 10.1124/jpet.103.050104  0.36
2003 Katsuki H, Shibata H, Takenaka C, Kume T, Kaneko S, Akaike A. N-methyl-D-aspartate receptors contribute to the maintenance of dopaminergic neurons in rat midbrain slice cultures Neuroscience Letters. 341: 123-126. PMID 12686381 DOI: 10.1016/S0304-3940(03)00176-9  0.36
2003 Takahata K, Katsuki H, Kume T, Nakata D, Ito K, Muraoka S, Yoneda F, Kashii S, Honda Y, Akaike A. Retinal neuronal death induced by intraocular administration of a nitric oxide donor and its rescue by neurotrophic factors in rats Investigative Ophthalmology and Visual Science. 44: 1760-1766. PMID 12657619 DOI: 10.1167/iovs.02-0471  0.36
2003 Osakada F, Hashino A, Kume T, Katsuki H, Kaneko S, Akaike A. Neuroprotective effects of alpha-tocopherol on oxidative stress in rat striatal cultures. European Journal of Pharmacology. 465: 15-22. PMID 12650828 DOI: 10.1016/S0014-2999(03)01495-X  0.36
2003 Kitamura Y, Ishida Y, Takata K, Mizutani H, Kakimura J, Inden M, Nakata J, Taniguchi T, Tsukahara T, Akaike A, Shimohama S. Hyperbilirubinemia protects against focal ischemia in rats. Journal of Neuroscience Research. 71: 544-50. PMID 12548710 DOI: 10.1002/jnr.10514  0.36
2003 Nakamizo T, Kawamata J, Yoshida K, Kawai Y, Kanki R, Sawada H, Kihara T, Yamashita H, Shibasaki H, Akaike A, Shimohama S. Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons. Journal of Neuroscience Research. 71: 485-95. PMID 12548704 DOI: 10.1002/jnr.10483  0.36
2003 Takahata K, Katsuki H, Kobayashi Y, Muraoka S, Yoneda F, Kume T, Kashii S, Honda Y, Akaike A. Protective effects of selegiline and desmethylselegiline against N-methyl-D-aspartate-induced rat retinal damage. European Journal of Pharmacology. 458: 81-9. PMID 12498910 DOI: 10.1016/S0014-2999(02)02729-2  0.36
2002 Kume T, Nishikawa H, Taguchi R, Hashino A, Katsuki H, Kaneko S, Minami M, Satoh M, Akaike A. Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro. European Journal of Pharmacology. 455: 91-100. PMID 12445574 DOI: 10.1016/S0014-2999(02)02582-7  0.36
2002 Manabe SI, Kashii S, Honda Y, Yamamoto R, Katsuki H, Akaike A. Quantification of axotomized ganglion cell death by explant culture of the rat retina Neuroscience Letters. 334: 33-36. PMID 12431769 DOI: 10.1016/S0304-3940(02)01047-9  0.36
2002 Shirakawa H, Katsuki H, Kume T, Kaneko S, Ito J, Akaike A. Regulation of N-methyl-D-aspartate cytotoxicity by neuroactive steroids in rat cortical neurons European Journal of Pharmacology. 454: 165-175. PMID 12421643 DOI: 10.1016/S0014-2999(02)02493-7  0.36
2002 Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Kanki R, Yamashita H, Akaike A. Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. Journal of Neuroscience Research. 70: 274-82. PMID 12391586 DOI: 10.1002/jnr.10426  0.36
2002 Katayama T, Minami M, Nakamura M, Ito M, Katsuki H, Akaike A, Satoh M. Excitotoxic injury induces production of monocyte chemoattractant protein-1 in rat cortico-striatal slice cultures. Neuroscience Letters. 328: 277-80. PMID 12147325 DOI: 10.1016/S0304-3940(02)00550-5  0.36
2002 Sawada H, Ibi M, Kihara T, Honda K, Nakamizo T, Kanki R, Nakanishi M, Sakka N, Akaike A, Shimohama S. Estradiol protects dopaminergic neurons in a MPP+Parkinson's disease model. Neuropharmacology. 42: 1056-64. PMID 12128007 DOI: 10.1016/S0028-3908(02)00049-7  0.36
2002 Wang XD, Kashii S, Zhao L, Tonchev AB, Katsuki H, Akaike A, Honda Y, Yamashita J, Yamashima T. Vitamin B6 protects primate retinal neurons from ischemic injury Brain Research. 940: 36-43. PMID 12020872 DOI: 10.1016/S0006-8993(02)02587-8  0.36
2002 Kume T, Asai N, Nishikawa H, Mano N, Terauchi T, Taguchi R, Shirakawa H, Osakada F, Mori H, Asakawa N, Yonaga M, Nishizawa Y, Sugimoto H, Shimohama S, Katsuki H, ... ... Akaike A, et al. Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum. Proceedings of the National Academy of Sciences of the United States of America. 99: 3288-93. PMID 11867740 DOI: 10.1073/pnas.052693999  0.36
2002 Akaike A, Katsuki H, Kume T. Role of nitric oxide in survival and death of neurons Folia Pharmacologica Japonica. 119: 15-20. PMID 11862752 DOI: 10.1254/fpj.119.15  0.36
2002 Yoshida K, Nakagawa T, Kaneko S, Akaike A, Satoh M. Adenosine 5′-triphosphate inhibits slow depolarization induced by repetitive dorsal root stimulation via P2Y purinoceptors in substantia gelatinosa neurons of the adult rat spinal cord slices with the dorsal root attached Neuroscience Letters. 320: 121-124. PMID 11852177 DOI: 10.1016/S0304-3940(02)00018-6  0.36
2002 Yasuyoshi H, Kashii S, Kikuchi M, Zhang S, Honda Y, Akaike A. New insight into the functional role of acetylcholine in developing embryonic rat retinal neurons Investigative Ophthalmology and Visual Science. 43: 446-451. PMID 11818389  0.36
2002 Kaneko S, Cooper CB, Nishioka N, Yamasaki H, Suzuki A, Jarvis SE, Akaike A, Satoh M, Zamponi GW. Identification and characterization of novel human Ca(v)2.2 (alpha 1B) calcium channel variants lacking the synaptic protein interaction site. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 82-92. PMID 11756491  0.36
2002 Terauchi T, Asai N, Yonaga M, Kume T, Akaike A, Sugimoto H. Synthesis and absolute configuration of serofendic acids Tetrahedron Letters. 43: 3625-3628. DOI: 10.1016/S0040-4039(02)00651-2  0.36
2001 Kanki H, Kinoshita M, Akaike A, Satoh M, Mori Y, Kaneko S. Activation of inositol 1,4,5-trisphosphate receptor is essential for the opening of mouse TRP5 channels Molecular Pharmacology. 60: 989-998. PMID 11641427  0.36
2001 Shimazu S, Takahata K, Katsuki H, Tsunekawa H, Tanigawa A, Yoneda F, Knoll J, Akaike A. ( - )-1-(Benzofuran-2-yl)-2-propylaminopentane enhances locomotor activity in rats due to its ability to induce dopamine release European Journal of Pharmacology. 421: 181-189. PMID 11516435 DOI: 10.1016/S0014-2999(01)01040-8  0.36
2001 Kinoshita M, Nukada T, Asano T, Mori Y, Akaike A, Satoh M, Kaneko S. Binding of Gαo N Terminus Is Responsible for the Voltage-resistant Inhibition of α1A (P/Q-type, Ca v2.1) Ca2+ Channels Journal of Biological Chemistry. 276: 28731-28738. PMID 11395521 DOI: 10.1074/jbc.M104806200  0.36
2001 Honda K, Shimohama S, Sawada H, Kihara T, Nakamizo T, Shibasaki H, Akaike A. Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons. Journal of Neuroscience Research. 64: 466-75. PMID 11391701 DOI: 10.1002/jnr.1098  0.36
2001 Ibi M, Sawada H, Nakanishi M, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A. Protective effects of 1 alpha,25-(OH)(2)D(3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture. Neuropharmacology. 40: 761-71. PMID 11369030 DOI: 10.1016/S0028-3908(01)00009-0  0.36
2001 Kitamura Y, Ishida Y, Takata K, Kakimura J, Mizutani H, Shimohama S, Akaike A, Taniguchi T. Alpha-synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia. Brain Research. 898: 181-5. PMID 11292464 DOI: 10.1016/S0006-8993(01)02159-X  0.36
2001 Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A. alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. The Journal of Biological Chemistry. 276: 13541-6. PMID 11278378 DOI: 10.1074/jbc.M008035200  0.36
2001 Katsuki H, Tomita M, Takenaka C, Shirakawa H, Shimazu S, Ibi M, Kume T, Kaneko S, Akaike A. Superoxide dismutase activity in organotypic midbrain-striatum co-cultures is associated with resistance of dopaminergic neurons to excitotoxicity Journal of Neurochemistry. 76: 1336-1345. PMID 11238718 DOI: 10.1046/j.1471-4159.2001.00136.x  0.36
2001 Katsuki H, Takenaka C, Kume T, Kaneko S, Akaike A. Requirement of neural activity for the maintenance of dopaminergic neurons in rat midbrain slice cultures Neuroscience Letters. 300: 166-170. PMID 11226637 DOI: 10.1016/S0304-3940(01)01570-1  0.36
2001 Urushitani M, Nakamizo T, Inoue R, Sawada H, Kihara T, Honda K, Akaike A, Shimohama S. N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx. Journal of Neuroscience Research. 63: 377-87. PMID 11223912 DOI: 10.1002/1097-4547(20010301)63:5<377::AID-JNR1032>3.0.CO;2-#  0.36
1999 Akaike A, Katsuki H, Kume T, Maeda T. Reactive oxygen species in NMDA receptor-mediated glutamate neurotoxicity. Parkinsonism & Related Disorders. 5: 203-7. PMID 18591141  0.32
1985 Shaw KP, Aracava Y, Akaike A, Daly JW, Rickett DL, Albuquerque EX. The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex. Molecular Pharmacology. 28: 527-38. PMID 2417099  0.44
1984 Albuquerque EX, Akaike A, Shaw KP, Rickett DL. The interaction of anticholinesterase agents with the acetylcholine receptor-ionic channel complex. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 4: S27-33. PMID 6327444 DOI: 10.1016/0272-0590(84)90135-0  0.44
1984 Pascuzzo GJ, Akaike A, Maleque MA, Shaw KP, Aronstam RS, Rickett DL, Albuquerque EX. The nature of the interactions of pyridostigmine with the nicotinic acetylcholine receptor-ionic channel complex. I. Agonist, desensitizing, and binding properties. Molecular Pharmacology. 25: 92-101. PMID 6323955  0.44
1984 Akaike A, Ikeda SR, Brookes N, Pascuzzo GJ, Rickett DL, Albuquerque EX. The nature of the interactions of pyridostigmine with the nicotinic acetylcholine receptor-ionic channel complex. II. Patch clamp studies. Molecular Pharmacology. 25: 102-12. PMID 6323946  0.44
1984 Allen CN, Akaike A, Albuquerque EX. The frog interosseal muscle fiber as a new model for patch clamp studies of chemosensitive- and voltage-sensitive ion channels: actions of acetylcholine and batrachotoxin. Journal De Physiologie. 79: 338-43. PMID 6099417  0.44
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