David Gate, PhD - Related publications

2015 University of Southern California, Los Angeles, CA, United States 
 2015- Neurology Stanford University, Palo Alto, CA 
Alzheimer's disease, Aging, Neuroimmunology
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Kupz A, Pai S, Giacomin PR, Whan JA, Walker RA, Hammoudi PM, Smith NC, Miller CM. Treatment of mice with S4B6 IL-2 complex prevents lethal toxoplasmosis via IL-12- and IL-18-dependent interferon-gamma production by non-CD4 immune cells. Scientific Reports. 10: 13115. PMID 32753607 DOI: 10.1038/s41598-020-70102-1   
2020 Santos ARD, Fraga-Silva TF, F Almeida D, Dos Santos RF, Finato AC, Amorim BC, Andrade MI, Soares CT, Lara VS, Almeida NL, de Arruda OS, de Arruda MS, Venturini J. -host interplay of disseminated mucormycosis in immunocompetent mice. Future Microbiology. PMID 32686962 DOI: 10.2217/fmb-2019-0246   
2020 Tuyji Tok Y, Şener AG, Aksoy Gökmen A, Demirdal T, Kaya S. [Investigation of Regulatory T Cells and Secreted Immunomodulatory Cytokine IL-10 Levels in Patients with Hepatitis B]. Mikrobiyoloji Bulteni. 54: 266-278. PMID 32723282 DOI: 10.5578/mb.69340   
2020 De Pascalis R, Rossi AP, Mittereder L, Takeda K, Akue A, Kurtz SL, Elkins KL. Production of IFN-γ by splenic dendritic cells during innate immune responses against Francisella tularensis LVS depends on MyD88, but not TLR2, TLR4, or TLR9. Plos One. 15: e0237034. PMID 32745117 DOI: 10.1371/journal.pone.0237034   
2020 Poudel B, Yorek MS, Mazgaeen L, Brown SA, Kanneganti TD, Gurung P. Acute IL-4 Governs Pathogenic T Cell Responses during Infection. Immunohorizons. 4: 546-560. PMID 32948646 DOI: 10.4049/immunohorizons.2000076   
2020 Ma K, Du W, Xiao F, Han M, Huang E, Peng N, Tang Y, Deng C, Liu L, Chen Y, Li J, Yuan S, Huang Q, Hong X, Hu D, et al. IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis. Cellular & Molecular Immunology. PMID 32917979 DOI: 10.1038/s41423-020-00540-4   
2020 Lage DP, Ribeiro PAF, Dias DS, Mendonça DVC, Ramos FF, Carvalho LM, de Oliveira D, Steiner BT, Martins VT, Perin L, Machado AS, Santos TTO, Tavares GSV, Oliveira-da-Silva JA, Oliveira JS, et al. A candidate vaccine for human visceral leishmaniasis based on a specific T cell epitope-containing chimeric protein protects mice against infection. Npj Vaccines. 5: 75. PMID 32821440 DOI: 10.1038/s41541-020-00224-0   
2020 Di Pietro M, Filardo S, Alfano V, Pelloni M, Splendiani E, Po A, Paoli D, Ferretti E, Sessa R. elicits TLR3 expression but disrupts the inflammatory signaling down-modulating NFκB and IRF3 transcription factors in human Sertoli cells. Journal of Biological Regulators and Homeostatic Agents. 34: 977-986. PMID 32664712 DOI: 10.23812/20-80-A-29   
2020 de Brito Toscano EC, da Cunha Sousa LF, Ferreira RN, Lima GK, de Miranda AS, Mesquita LA, Soriani FM, Campos MA, Kroon EG, Vasconcelos AC, Vilela MC, Teixeira MM, Teixeira AL, Rachid MA. Neuroinflammation is associated with reduced SOCS2 and SOCS3 expression during intracranial HSV-1 infection. Neuroscience Letters. 135295. PMID 32800922 DOI: 10.1016/j.neulet.2020.135295   
2020 Lim JS, Kim JY, Lee S, Choi JK, Kim EN, Choi YA, Jang YH, Jeong GS, Kim SH. Bakuchicin attenuates atopic skin inflammation. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 129: 110466. PMID 32768955 DOI: 10.1016/j.biopha.2020.110466   
2020 Fernandes LGR, Perez-Riverol A, Bazon ML, Abram DM, Brochetto-Braga MR, Zollner RL. Functional Profile of Antigen Specific CD4 T Cells in the Immune Response to Phospholipase A1 Allergen from Venom. Toxins. 12. PMID 32521656 DOI: 10.3390/toxins12060379   
2020 Angkasekwinai P, Dong C. IL-9-producing T cells: potential players in allergy and cancer. Nature Reviews. Immunology. PMID 32788707 DOI: 10.1038/s41577-020-0396-0   
2020 Crawford MP, Sinha S, Renavikar PS, Borcherding N, Karandikar NJ. CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression. Proceedings of the National Academy of Sciences of the United States of America. PMID 32719138 DOI: 10.1073/pnas.2005010117   
2020 Segueni N, Jacobs M, Ryffel B. Innate type 1 immune response, but not IL-17 cells control tuberculosis infection. Biomedical Journal. PMID 32798210 DOI: 10.1016/j.bj.2020.06.011   
2020 Dadaglio G, Fayolle C, Oberkampf M, Tang A, Rudilla F, Couillin I, Torheim EA, Rosenbaum P, Leclerc C. IL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8 T-cell responses. Oncoimmunology. 9: 1758606. PMID 32923117 DOI: 10.1080/2162402X.2020.1758606   
2020 Panigrahi S, Chen B, Fang M, Potashnikova D, Komissarov AA, Lebedeva A, Michaelson GM, Wyrick JM, Morris SR, Sieg SF, Paiardini M, Villinger FJ, Harth K, Kashyap VS, Cameron MJ, et al. CX3CL1 and IL-15 Promote CD8 T cell chemoattraction in HIV and in atherosclerosis. Plos Pathogens. 16: e1008885. PMID 32976527 DOI: 10.1371/journal.ppat.1008885   
2020 Almanan M, Raynor J, Ogunsulire I, Malyshkina A, Mukherjee S, Hummel SA, Ingram JT, Saini A, Xie MM, Alenghat T, Way SS, Deepe GS, Divanovic S, Singh H, Miraldi E, et al. IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression. Science Advances. 6: eabb0806. PMID 32832688 DOI: 10.1126/sciadv.abb0806   
2020 Mezouar S, Lepidi H, Omar Osman I, Gorvel JP, Raoult D, Mege JL, Bechah Y. T-Bet Controls Susceptibility of Mice to Infection. Frontiers in Microbiology. 11: 1546. PMID 32765448 DOI: 10.3389/fmicb.2020.01546   
2020 He F, Qin X, Xu N, Li P, Wu X, Duan L, Du Y, Fang R, Hardwidge PR, Li N, Peng Y. Pm0442 Affects Virulence Gene Expression and Targets TLR2 to Induce Inflammatory Responses. Frontiers in Microbiology. 11: 1972. PMID 32922380 DOI: 10.3389/fmicb.2020.01972   
2020 Duan F, Guo L, Yang L, Han Y, Thakur A, Nilsson-Payant BE, Wang P, Zhang Z, Ma CY, Zhou X, Han T, Zhang T, Wang X, Xu D, Duan X, et al. Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2. Research Square. PMID 32839764 DOI: 10.21203/rs.3.rs-62758/v1   
2020 Abbas AK. The Surprising Story of IL-2: From Experimental Models to Clinical Application. The American Journal of Pathology. 190: 1776-1781. PMID 32828360 DOI: 10.1016/j.ajpath.2020.05.007   
2020 Liu X, Boyer MA, Holmgren AM, Shin S. Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial Inflammation. Cell Host & Microbe. PMID 32841604 DOI: 10.1016/j.chom.2020.07.019   
2020 Peng J, Xiao Y, Wan X, Chen Q, Wang H, Li J, Chen J, Gao R. Enhancement of Immune Response and Anti-Infection of Mice by Porcine Antimicrobial Peptides and Interleukin-4/6 Fusion Gene Encapsulated in Chitosan Nanoparticles. Vaccines. 8. PMID 32967351 DOI: 10.3390/vaccines8030552   
2020 Peng J, Xiao Y, Wan X, Chen Q, Wang H, Li J, Chen J, Gao R. Enhancement of Immune Response and Anti-Infection of Mice by Porcine Antimicrobial Peptides and Interleukin-4/6 Fusion Gene Encapsulated in Chitosan Nanoparticles. Vaccines. 8. PMID 32967351 DOI: 10.3390/vaccines8030552   
2020 Yang X, Xia YH, Wang JY, Li YT, Chang YF, Chang HT, Liu HY, Chen L, Wang CQ. The role of GtxA during Gallibacterium anatis infection of primary chicken oviduct epithelial cells. Molecular and Cellular Probes. 101641. PMID 32735874 DOI: 10.1016/j.mcp.2020.101641   
2020 Shimba A, Ikuta K. Immune-enhancing effects of glucocorticoids in response to day-night cycles and stress. International Immunology. PMID 32710629 DOI: 10.1093/intimm/dxaa048   
2020 M Povroznik J, Robinson CM. IL-27 regulation of innate immunity and control of microbial growth. Future Science Oa. 6: FSO588. PMID 32802395 DOI: 10.2144/fsoa-2020-0032   
2020 Conti P, Caraffa A, Tetè G, Gallenga CE, Ross R, Kritas SK, Frydas I, Younes A, Di Emidio P, Ronconi G. Mast cells activated by SARS-CoV-2 release histamine which increases IL-1 levels causing cytokine storm and inflammatory reaction in COVID-19. Journal of Biological Regulators and Homeostatic Agents. 34. PMID 32945158 DOI: 10.23812/20-2EDIT   
2020 Gandhi J, Naik P, Kaur I, Kumar A, Joseph J. Microglial Response to and : Implications in Endophthalmitis. Journal of Fungi (Basel, Switzerland). 6. PMID 32899547 DOI: 10.3390/jof6030162   
2020 Qi J, Zhang Z, Tang X, Li W, Chen W, Yao G. IL-27 Regulated CD4IL-10 T Cells in Experimental Sjögren Syndrome. Frontiers in Immunology. 11: 1699. PMID 32849596 DOI: 10.3389/fimmu.2020.01699   
2020 Wang WW, Wang Y, Li K, Tadagavadi R, Friedrichs WE, Budatha M, Reeves WB. IL-10 from dendritic cells but not from T regulatory cells protects against cisplatin-induced nephrotoxicity. Plos One. 15: e0238816. PMID 32898157 DOI: 10.1371/journal.pone.0238816   
2020 Tosti N, Cremonesi E, Governa V, Basso C, Kancherla V, Coto-Llerena M, Amicarella F, Weixler B, Däster S, Sconocchia G, Majno PE, Christoforidis D, Tornillo L, Terracciano L, Ng CKY, et al. Infiltration by interleukin-22 producing T cells promotes neutrophil recruitment and predicts favorable clinical outcome in human colorectal cancer. Cancer Immunology Research. PMID 32839156 DOI: 10.1158/2326-6066.CIR-19-0934   
2020 Huang X, Yang W, Yao S, Bilotta AJ, Lu Y, Zhou Z, Kumar P, Dann SM, Cong Y. IL-21 Promotes Intestinal Memory IgA Responses. Journal of Immunology (Baltimore, Md. : 1950). PMID 32859726 DOI: 10.4049/jimmunol.1900766   
2020 Krause G, Hassenrück F, Hallek M. Relevant Cytokines in the B Cell Lymphoma Micro-Environment. Cancers. 12. PMID 32899476 DOI: 10.3390/cancers12092525   
2020 Keewan E, Naser SA. Notch-1 Signaling Modulates Macrophage Polarization and Immune Defense against Infection in Inflammatory Diseases. Microorganisms. 8. PMID 32635645 DOI: 10.3390/microorganisms8071006   
2020 Muthusami S, Kumaran RI, Babu KN, Krishnamoorthy S, Guruswamy A, Queimado L, Chaudhuri G, Ramachandran I. Role of inflammation in the development of colorectal cancer. Endocrine, Metabolic & Immune Disorders Drug Targets. PMID 32901590 DOI: 10.2174/1871530320666200909092908   
2020 Chen C, Xu H, Peng Y, Luo H, Huang GX, Wu XJ, Dai YC, Luo HL, Zhang JA, Zheng BY, Zhang XN, Chen ZW, Xu JF. Elevation in the counts of IL-35-producing B cells infiltrating into lung tissue in mycobacterial infection is associated with the downregulation of Th1/Th17 and upregulation of Foxp3Treg. Scientific Reports. 10: 13212. PMID 32764544 DOI: 10.1038/s41598-020-69984-y   
2020 Cao G, Zhang X, Song Y, Sun Y, Ling H, Han X, Lin J. Local promotion of B10 function alleviates experimental periodontitis bone loss through antagonizing Receptor Activator of NF-KappaB Ligand-expressing neutrophils. Journal of Periodontology. PMID 32845513 DOI: 10.1002/JPER.20-0074   
2020 Jin SW, Lee GH, Jang MJ, Hong GE, Kim JY, Park GD, Jin H, Kim HS, Choi JH, Choi CY, Lee SG, Jeong HG, Hwang YP. Immunomodulatory Activity of GCWB1176 in Cyclophosphamide-Induced Immunosuppression Model. Microorganisms. 8. PMID 32748895 DOI: 10.3390/microorganisms8081175   
2020 Chamoun MN, Sullivan MJ, Goh KGK, Acharya D, Ipe DS, Katupitiya L, Gosling D, Peters KM, Sweet MJ, Sester DP, Schembri MA, Ulett GC. Restriction of chronic Escherichia coli urinary tract infection depends upon T cell-derived interleukin-17, a deficiency of which predisposes to flagella-driven bacterial persistence. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32901999 DOI: 10.1096/fj.202000760R   
2020 Zhou Q, Zhang H, Wang Z, Zeng H, Liu Z, Huang Q, Lin Z, Qu Y, Xiong Y, Wang J, Chang Y, Bai Q, Xia Y, Wang Y, Liu L, et al. Poor clinical outcomes and immunoevasive contexture in interleukin-9 abundant muscle-invasive bladder cancer. International Journal of Cancer. PMID 32734613 DOI: 10.1002/ijc.33237   
2020 Qin SK, Li Q, Xu JM, Liang J, Cheng Y, Fan Y, Jiang J, Ye H, Tao H, Li L, Zheng L, Wei Z, Li S, Meng K, Ye B, et al. Icaritin Induced Immunomodulatory Efficacy in Advanced HBV-Related Hepatocellular Carcinoma:Immunodynamic Biomarkers and Overall Survival. Cancer Science. PMID 32889778 DOI: 10.1111/cas.14641   
2020 Liu H, Liu P, Sun D, Xing D, Wang X, Yang J, Wang S. Adenovirus-mediated overexpression of interleukin-21 regulates the development of oral squamous cell carcinoma . Oncology Letters. 20: 3006-3014. PMID 32782618 DOI: 10.3892/ol.2020.11822   
2020 Wilharm A, Brigas HC, Sandrock I, Ribeiro M, Amado T, Reinhardt A, Demera A, Hoenicke L, Strowig T, Carvalho T, Prinz I, Ribot JC. Microbiota-dependent expansion of testicular IL-17-producing Vγ6 γδ T cells upon puberty promotes local tissue immune surveillance. Mucosal Immunology. PMID 32733025 DOI: 10.1038/s41385-020-0330-6   
2020 Cunha LL, Perazzio SF, Azzi J, Cravedi P, Riella LV. Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response. Frontiers in Immunology. 11: 1748. PMID 32849623 DOI: 10.3389/fimmu.2020.01748   
2020 Kale SD, Mehrkens BN, Stegman MM, Kastelberg B, Carnes H, McNeill RJ, Rizzo A, Karyala SV, Coutermarsh-Ott S, Fretz JA, Sun Y, Koff JL, Rajagopalan G. "Small" Intestinal Immunopathology Plays a "Big" Role in Lethal Cytokine Release Syndrome, and Its Modulation by Interferon-γ, IL-17A, and a Janus Kinase Inhibitor. Frontiers in Immunology. 11: 1311. PMID 32676080 DOI: 10.3389/fimmu.2020.01311   
2020 Giuffrida L, Sek K, Henderson MA, House IG, Lai J, Chen AXY, Todd KL, Petley EV, Mardiana S, Todorovski I, Gruber E, Kelly MJ, Solomon BJ, Vervoort SJ, Johnstone RW, et al. IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 32735774 DOI: 10.1016/j.ymthe.2020.07.018   
2020 Miyagawa F, Tagaya Y, Ozato K, Horie K, Asada H. Inflammatory monocyte-derived dendritic cells mediate autoimmunity in murine model of systemic lupus erythematosus. Journal of Translational Autoimmunity. 3: 100060. PMID 32743540 DOI: 10.1016/j.jtauto.2020.100060   
2020 Liang Y, Yi P, Ru W, Jie Z, Wang H, Ghanayem T, Wang X, Alamer E, Liu J, Hu H, Soong L, Cai J, Sun J. IL-22 hinders antiviral T cell responses and exacerbates ZIKV encephalitis in immunocompetent neonatal mice. Journal of Neuroinflammation. 17: 249. PMID 32843067 DOI: 10.1186/s12974-020-01928-9   
2020 Pei L, Gao X, Liu W, Feng X, Zhao Z, Lai Y. Lapiferin protects against H1N1 virus-induced pulmonary inflammation by negatively regulating NF-kB signaling. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas. 53: e9183. PMID 32901688 DOI: 10.1590/1414-431X20209183