David Gate, PhD - Related publications

Affiliations: 
2015 University of Southern California, Los Angeles, CA, United States 
 2015-2021 Neurology Stanford University, Palo Alto, CA 
 2021- Neurology Northwestern University, Evanston, IL 
Area:
Alzheimer's disease, Aging, Neuroimmunology
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Snyder LM, Doherty CM, Mercer HL, Denkers EY. Induction of IL-12p40 and type 1 immunity by Toxoplasma gondii in the absence of the TLR-MyD88 signaling cascade. Plos Pathogens. 17: e1009970. PMID 34597344 DOI: 10.1371/journal.ppat.1009970   
2021 Rojo JM, Montes-Casado M, Aragoneses-Fenoll L, Ojeda G, Dianzani U, Portolés P. PI3-Kinase p110α Deficiency Modulates T Cell Homeostasis and Function and Attenuates Experimental Allergic Encephalitis in Mature Mice. International Journal of Molecular Sciences. 22. PMID 34445401 DOI: 10.3390/ijms22168698   
2021 Li H, Zhu L, Wang R, Xie L, Ren J, Ma S, Zhang W, Liu X, Huang Z, Chen B, Li Z, Feng H, Liu GH, Wang S, Qu J, et al. Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice. Protein & Cell. PMID 34748200 DOI: 10.1007/s13238-021-00882-3   
2021 Chakrabarti S, Prorok T, Roy A, Patel D, Dasarathi S, Pahan K. Upregulation of IL-1 Receptor Antagonist by Aspirin in Glial Cells via Peroxisome Proliferator-Activated Receptor-Alpha. Journal of Alzheimer's Disease Reports. 5: 647-661. PMID 34632302 DOI: 10.3233/ADR-210026   
2021 Kuo CF, Chen WY, Yu HH, Tsai YH, Chang YC, Chang CP, Tsao N. IL-33/ST2 Axis Plays a Protective Effect in Infection through Strengthening of the Innate Immunity. International Journal of Molecular Sciences. 22. PMID 34638904 DOI: 10.3390/ijms221910566   
2021 Bai Y, Guan F, Zhu F, Jiang C, Xu X, Zheng F, Liu W, Lei J. IL-33/ST2 Axis Deficiency Exacerbates Hepatic Pathology by Regulating Treg and Th17 Cells in Murine Schistosomiasis Japonica. Journal of Inflammation Research. 14: 5981-5998. PMID 34815688 DOI: 10.2147/JIR.S336404   
2021 Hajjar S, Nathan N, Joseph J, Mottawea W, Ariana A, Pyatibrat S, Harper ME, Alain T, Blais A, Russell RC, Sad S. Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10 model of colitis. Cell Death and Differentiation. PMID 34588632 DOI: 10.1038/s41418-021-00876-y   
2021 Xie L, Saimaier K, Wang C, Yang J, Han M, Lv J, Zhuang W, Liu G, Du C. Methyl acetate arrests Th1 in peripheral immune system and alleviates CNS inflammation in EAE. International Immunopharmacology. 108291. PMID 34799286 DOI: 10.1016/j.intimp.2021.108291   
2021 Roy U, de Oliveira RS, Galvez EJC, Gronow A, Basic M, Perez LG, Gagliani N, Bleich A, Huber S, Strowig T. Induction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells. Frontiers in Immunology. 12: 671331. PMID 34566952 DOI: 10.3389/fimmu.2021.671331   
2021 Huang J, Xu K, Yu L, Pu Y, Wang T, Sun R, Liang G, Yin L, Zhang J, Pu Y. Immunosuppression characterized by increased Treg cell and IL-10 levels in benzene-induced hematopoietic toxicity mouse model. Toxicology. 152990. PMID 34673135 DOI: 10.1016/j.tox.2021.152990   
2021 Li C, Yu T, Shi X, Yu J. Interleukin-33 Reinvigorates Antiviral Function of Viral-Specific CD8 T Cells in Chronic Hepatitis B Virus Infection. Viral Immunology. PMID 34818081 DOI: 10.1089/vim.2021.0140   
2021 Suwanpradid J, Lee MJ, Hoang P, Kwock J, Floyd LP, Smith JS, Yin Z, Atwater AR, Rajagopal S, Kedl RM, Corcoran DL, Zhang JY, MacLeod AS. IL-27 Derived From Macrophages Facilitates IL-15 Production and T Cell Maintenance Following Allergic Hypersensitivity Responses. Frontiers in Immunology. 12: 713304. PMID 34659203 DOI: 10.3389/fimmu.2021.713304   
2021 Hlaka L, Ozturk M, Chia JE, Jones SS, Pillay S, Poswayo SKL, Mpotje T, Nono JK, Simelane S, Parihar SP, Roy S, Suzuki H, Brombacher F, Guler R. IL-4i1 regulates immune protection during Mycobacterium tuberculosis infection. The Journal of Infectious Diseases. PMID 34739044 DOI: 10.1093/infdis/jiab558   
2021 Nouveau L, Buatois V, Cons L, Chatel L, Pontini G, Pleche N, Ferlin WG. Immunological analysis of the murine anti-CD3-induced cytokine release syndrome model and therapeutic efficacy of anti-cytokine antibodies. European Journal of Immunology. 51: 2074-2085. PMID 33945643 DOI: 10.1002/eji.202149181   
2021 Oh JS, Lee SJ, Choung SY. Alleviates Atopic Dermatitis-like Skin Lesions by Restoring Immune Balance and Skin Barrier Function in 2.4-Dinitrochlorobenzene-Induced NC/Nga Mice. Nutrients. 13. PMID 34579088 DOI: 10.3390/nu13093209   
2021 Bjanes E, Sillas RG, Matsuda R, Demarco B, Fettrelet T, DeLaney AA, Kornfeld OS, Lee BL, Rodríguez López EM, Grubaugh D, Wynosky-Dolfi MA, Philip NH, Krespan E, Tovar D, Joannas L, et al. Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection. Plos Pathogens. 17: e1009967. PMID 34648590 DOI: 10.1371/journal.ppat.1009967   
2021 Manigat LC, Granade ME, Taori S, Miller CA, Vass LR, Zhong XP, Harris TE, Purow BW. Loss of Diacylglycerol Kinase α Enhances Macrophage Responsiveness. Frontiers in Immunology. 12: 722469. PMID 34804012 DOI: 10.3389/fimmu.2021.722469   
2021 Zhang Y, Wang X, Yang X, Yang X, Xue J, Yang Y. Ganoderic Acid A To Alleviate Neuroinflammation of Alzheimer's Disease in Mice by Regulating the Imbalance of the Th17/Tregs Axis. Journal of Agricultural and Food Chemistry. PMID 34798773 DOI: 10.1021/acs.jafc.1c06304   
2021 Liu X, Hu Z, Zhang J, Ma T, Wu W, Wei X, Wang Z, Zhen H, Zhou H, Huang N, Li J. IL-30 ameliorates imiquimod and K14-VEGF induced psoriasis-like disease by inhibiting both innate and adaptive immunity disorders. Biochemical and Biophysical Research Communications. 579: 97-104. PMID 34597998 DOI: 10.1016/j.bbrc.2021.09.042   
2021 Ruiz-Jiménez C, Celias D, Valdés B, Ramos-Pérez WD, Cervi L, Espino AM. Fasciola hepatica fatty acid binding protein (Fh12) induces apoptosis and tolerogenic properties in murine bone marrow derived dendritic cells. Experimental Parasitology. 231: 108174. PMID 34752732 DOI: 10.1016/j.exppara.2021.108174   
2021 Chen BR, Hsu KT, Li TL, Chan YL, Wu CJ. Topical application of fucoidan derived from Cladosiphon okamuranus alleviates atopic dermatitis symptoms through immunomodulation. International Immunopharmacology. 108362. PMID 34801417 DOI: 10.1016/j.intimp.2021.108362   
2021 Wang S, Kozai M, Mita H, Cai Z, Masum MA, Ichii O, Takada K, Inaba M. REV-ERB agonist suppresses IL-17 production in γδT cells and improves psoriatic dermatitis in a mouse model. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 144: 112283. PMID 34628169 DOI: 10.1016/j.biopha.2021.112283   
2021 Kovtonyuk LV, Caiado F, Garcia-Martin S, Manz EM, Helbling PM, Takizawa H, Boettcher S, Al-Shahrour F, Nombela-Arrieta C, Slack E, Manz MG. IL-1 Mediates Microbiome-Induced Inflamm-Ageing of Hematopoietic Stem Cells in Mice. Blood. PMID 34525198 DOI: 10.1182/blood.2021011570   
2021 Baars I, Lokau J, Sauerland I, Müller AJ, Garbers C. Interleukin-11 receptor expression on monocytes is dispensable for their recruitment and pathogen uptake during Leishmania major infection. Cytokine. 148: 155699. PMID 34530329 DOI: 10.1016/j.cyto.2021.155699   
2021 Cannons JL, Villarino AV, Kapnick SM, Preite S, Shih HY, Gomez-Rodriguez J, Kaul Z, Shibata H, Reilley JM, Huang B, Handon R, McBain IT, Gossa S, Wu T, Su HC, et al. PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8 T cells at the expense of central memory. Cell Reports. 37: 109804. PMID 34644563 DOI: 10.1016/j.celrep.2021.109804   
2021 No H, Nam SH, Seo HW, Seo J, Park SH, Kim SB, Jung JS, Park J, Choi J, Lee JY, Suh HW, Lim SS, Kim JK. Purple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice. Animal Cells and Systems. 25: 272-282. PMID 34745434 DOI: 10.1080/19768354.2021.1974938   
2021 Jiang Y, Huang F, Chai X, Yuan W, Ding H, Wu X. The role of IP-10 and its receptor CXCR3 in early pregnancy. Molecular Immunology. 140: 59-69. PMID 34655920 DOI: 10.1016/j.molimm.2021.09.013   
2021 Olbei M, Thomas JP, Hautefort I, Treveil A, Bohar B, Madgwick M, Gul L, Csabai L, Modos D, Korcsmaros T. CytokineLink: A Cytokine Communication Map to Analyse Immune Responses-Case Studies in Inflammatory Bowel Disease and COVID-19. Cells. 10. PMID 34571891 DOI: 10.3390/cells10092242   
2021 Cardoso A, Martins AC, Maceiras AR, Liu W, Castro I, Castro AG, Bandeira A, Di Santo JP, Cumano A, Li Y, Vieira P, Saraiva M. Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis. Cell Reports. 37: 109887. PMID 34706233 DOI: 10.1016/j.celrep.2021.109887   
2021 Wang C, Yang J, Xie L, Saimaier K, Zhuang W, Han M, Liu G, Lv J, Shi G, Li N, Du C. Methyl Butyrate Alleviates Experimental Autoimmune Encephalomyelitis and Regulates the Balance of Effector T Cells and Regulatory T Cells. Inflammation. PMID 34786625 DOI: 10.1007/s10753-021-01596-8   
2021 Yan H, Lu J, Wang J, Chen L, Wang Y, Li L, Miao L, Zhang H. Prevention of Cyclophosphamide-Induced Immunosuppression in Mice With Traditional Chinese Medicine Xuanfei Baidu Decoction. Frontiers in Pharmacology. 12: 730567. PMID 34737699 DOI: 10.3389/fphar.2021.730567   
2021 Ghildiyal S, Fatima T, Singh D, Upadhyay S, Dhole TN, Himanshu Reddy D, Kumar A. Pro-inflammatory and anti-inflamatory cytokine genes polymorphisms and susceptibility to Japanese encephalitis disease in the North Indian population. Cytokine. 149: 155716. PMID 34634652 DOI: 10.1016/j.cyto.2021.155716   
2021 Berrien-Elliott MM, Becker-Hapak M, Cashen AF, Jacobs MT, Wong P, Foster M, McClain E, Desai S, Pence P, Cooley S, Brunstein CG, Gao F, Abboud CN, Uy GL, Westervelt P, et al. Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy. Blood. PMID 34797911 DOI: 10.1182/blood.2021011532   
2021 Brito CVB, Rodrigues ÉDL, Martins FMS, Tavares LD, Lima ALSN, Ferreira LC, Santana CJL, Brito JAGSM, Casseb LMN, Diniz Junior JAP. Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection. Revista Do Instituto De Medicina Tropical De Sao Paulo. 63: e28. PMID 33852711 DOI: 10.1590/S1678-9946202163028   
2021 Asadzadeh R, Ahmadpoor P, Nafar M, Samavat S, Nikoueinejad H, Hosseinzadeh M, Mamizadeh N, Hatami S, Masoumi E, Amirzargar A. Association of IL-15 and IP-10 Serum Levels with Cytomegalovirus Infection, CMV Viral Load and Cyclosporine Level after Kidney Transplantation. Reports of Biochemistry & Molecular Biology. 10: 216-223. PMID 34604411 DOI: 10.52547/rbmb.10.2.216   
2021 Ding Z, Cheng R, Yang Y, Zhao Y, Ge W, Sun X, Xu X, Wang S, Zhang J. The succinoglycan riclin restores beta cell function through the regulation of macrophages on Th1 and Th2 differentiation in type 1 diabetic mice. Food & Function. PMID 34714317 DOI: 10.1039/d1fo02315b   
2021 Snyder KJ, Choe HK, Gao Y, Sell NE, Braunreiter KM, Zitzer NC, Neidemire-Colley L, Kalyan S, Dorrance AM, Keller A, Mihaylova MM, Singh S, Sehgal L, Bollag G, Ma Y, et al. Inhibition of Bromodomain and Extra Terminal (BET) Domain Activity Modulates the IL-23R/IL-17 Axis and Suppresses Acute Graft--Host Disease. Frontiers in Oncology. 11: 760789. PMID 34722316 DOI: 10.3389/fonc.2021.760789   
2021 Leyva-Castillo JM, Das M, Kane J, Strakosha M, Singh S, Wong DSH, Horswill AR, Karasuyama H, Brombacher F, Miller LS, Geha RS. Basophil-derived IL-4 promotes cutaneous Staphylococcus aureus infection. Jci Insight. 6. PMID 34747366 DOI: 10.1172/jci.insight.149953   
2021 Chun J, Lee SM, Ahn YM, Baek MG, Yi H, Shin S, Jung J. Modulation of the Gut Microbiota by - Shapes the Immune Responses of Atopic Dermatitis. Frontiers in Pharmacology. 12: 722730. PMID 34616298 DOI: 10.3389/fphar.2021.722730   
2021 Howard JE, Smith JNP, Fredman G, MacNamara KC. IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock. Stem Cell Reports. PMID 34798063 DOI: 10.1016/j.stemcr.2021.10.011   
2021 Boki H, Kimura T, Miyagaki T, Suga H, Blauvelt A, Okochi H, Sugaya M, Sato S. Lymphatic dysfunction exacerbates cutaneous tumorigenesis and psoriasis-like skin inflammation through accumulation of inflammatory cytokines. The Journal of Investigative Dermatology. PMID 34780714 DOI: 10.1016/j.jid.2021.05.039   
2021 Ming S, Yin H, Li X, Gong S, Zhang G, Wu Y. GITR Promotes the Polarization of TFH-Like Cells in -Positive Gastritis. Frontiers in Immunology. 12: 736269. PMID 34589088 DOI: 10.3389/fimmu.2021.736269   
2021 Noto CN, Hoft SG, Bockerstett KA, Jackson NM, Ford EL, Vest LS, DiPaolo RJ. IL-13 acts directly on gastric epithelial cells to promote metaplasia development during chronic gastritis. Cellular and Molecular Gastroenterology and Hepatology. PMID 34587523 DOI: 10.1016/j.jcmgh.2021.09.012   
2021 Zebley CC, Abdelsamed HA, Ghoneim HE, Alli S, Brown C, Haydar D, Mi T, Harris T, McGargill MA, Krenciute G, Youngblood B. Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation. Cell Reports. 37: 109796. PMID 34644568 DOI: 10.1016/j.celrep.2021.109796   
2021 Bent EH, Millán-Barea LR, Zhuang I, Goulet DR, Fröse J, Hemann MT. Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy. Nature Communications. 12: 6218. PMID 34711820 DOI: 10.1038/s41467-021-26407-4   
2021 Oleszycka E, Rodgers AM, Xu L, Moynagh PN. Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway. Journal of Immunology (Baltimore, Md. : 1950). PMID 34588221 DOI: 10.4049/jimmunol.2100236   
2021 Yoon KW, Chu KB, Kang HJ, Kim MJ, Eom GD, Lee SH, Moon EK, Quan FS. Mucosal Administration of Recombinant Baculovirus Displaying ROP4 Confers Protection Against Challenge Infection in Mice. Frontiers in Cellular and Infection Microbiology. 11: 735191. PMID 34660343 DOI: 10.3389/fcimb.2021.735191   
2021 Ye C, Yano H, Workman CJ, Vignali DAA. Interleukin-35: Structure, Function and Its Impact on Immune-Related Diseases. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 41: 391-406. PMID 34788131 DOI: 10.1089/jir.2021.0147   
2021 Liu H, Zhou YC, Song W. Involvement of IL-10R/STAT3 pathway in amyloid β clearance by microlgia in Alzheimer's disease. International Immunopharmacology. 101: 108263. PMID 34710847 DOI: 10.1016/j.intimp.2021.108263   
2021 Otsuka R, Wada H, Seino KI. IL-34, the rationale of its expression in physiological and pathological condition. Seminars in Immunology. 101517. PMID 34774392 DOI: 10.1016/j.smim.2021.101517