Terrence C. Town, Ph.D. - Publications

Physiology and Biophysics University of Southern California, Los Angeles, CA, United States 
Alzheimer's disease, neuroimmunolgy

128 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Haghani A, Cacciottolo M, Doty KR, D'Agostino C, Thorwald M, Safi N, Levine ME, Sioutas C, Town TC, Forman HJ, Zhang H, Morgan TE, Finch CE. Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and in interactions. Elife. 9. PMID 32579111 DOI: 10.7554/eLife.54822  0.48
2018 Mori T, Koyama N, Tan J, Segawa T, Maeda M, Town T. Combined treatment with the phenolics (-)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice. The Journal of Biological Chemistry. PMID 30563837 DOI: 10.1074/jbc.RA118.004280  0.6
2018 Meyer PF, Savard M, Poirier J, Labonté A, Rosa-Neto P, Weitz TM, Town T, Breitner J. Bi-Directional Association of Cerebrospinal Fluid Immune Markers with Stage of Alzheimer's Disease Pathogenesis. Journal of Alzheimer's Disease : Jad. PMID 29660934 DOI: 10.3233/JAD-170887  0.52
2017 Mori T, Koyama N, Tan J, Segawa T, Maeda M, Town T. Combination Therapy with Octyl Gallate and Ferulic Acid Improves Cognition and Neurodegeneration in a Transgenic Mouse Model of Alzheimer Disease. The Journal of Biological Chemistry. PMID 28512130 DOI: 10.1074/jbc.M116.762658  0.6
2016 Guillot-Sestier MV, Weitz TM, Town T. Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease. Journal of Visualized Experiments : Jove. PMID 28060279 DOI: 10.3791/54868  0.56
2016 Breunig JJ, Levy R, Antonuk CD, Molina J, Dutra-Clarke M, Park H, Akhtar AA, Kim GB, Town T, Hu X, Bannykh SI, Verhaak RG, Danielpour M. Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma. Cell Reports. 17: 3407. PMID 28009307 DOI: 10.1016/j.celrep.2016.12.026  0.72
2016 Paul AM, Acharya D, Le L, Wang P, Stokic DS, Leis AA, Alexopoulou L, Town T, Flavell RA, Fikrig E, Bai F. TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 27798161 DOI: 10.4049/jimmunol.1600902  0.72
2016 Acharya D, Wang P, Paul AM, Dai J, Gate D, Lowery JE, Stokic DS, Leis AA, Flavell RA, Town T, Fikrig E, Bai F. Interleukin-17A Promotes CD8+ T Cell Cytotoxicity to Facilitate West Nile Virus Clearance. Journal of Virology. PMID 27795421 DOI: 10.1128/JVI.01529-16  0.72
2016 Weitz TM, Town T. Amyloid Cascade into Clarity. Immunity. 45: 717-718. PMID 27760336 DOI: 10.1016/j.immuni.2016.10.006  0.52
2016 Matundan HH, Mott KR, Allen SJ, Wang S, Bresee CJ, Ghiasi YN, Town T, Wechsler SL, Ghiasi H. Interrelationship of primary virus replication, level of latency and time to reactivate in the trigeminal ganglia of latently infected mice. Journal of Virology. PMID 27512072 DOI: 10.1128/JVI.01373-16  0.4
2016 Heneka M, Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, ... ... Town T, et al. Targeting innate immunity for neurodegenerative disorders of the central nervous system. Journal of Neurochemistry. PMID 27248001 DOI: 10.1111/jnc.13667  0.72
2016 Mott KR, Gate D, Matundan HH, Ghiasi YN, Town T, Ghiasi H. CD8+ T cells play a bystander role in HSV-1 latently infected mice. Journal of Virology. PMID 26962220 DOI: 10.1128/JVI.00255-16  0.56
2015 Daianu M, Jacobs RE, Weitz TM, Town TC, Thompson PM. Multi-Shell Hybrid Diffusion Imaging (HYDI) at 7 Tesla in TgF344-AD Transgenic Alzheimer Rats. Plos One. 10: e0145205. PMID 26683657 DOI: 10.1371/journal.pone.0145205  0.72
2015 Tseng CW, Biancotti JC, Berg BL, Gate D, Kolar SL, Müller S, Rodriguez MD, Rezai-Zadeh K, Fan X, Beenhouwer DO, Town T, Liu GY. Increased Susceptibility of Humanized NSG Mice to Panton-Valentine Leukocidin and Staphylococcus aureus Skin Infection. Plos Pathogens. 11: e1005292. PMID 26618545 DOI: 10.1371/journal.ppat.1005292  0.72
2015 Guillot-Sestier MV, Doty KR, Town T. Innate Immunity Fights Alzheimer's Disease. Trends in Neurosciences. 38: 674-81. PMID 26549882 DOI: 10.1016/j.tins.2015.08.008  0.72
2015 Gate D, Danielpour M, Bannykh S, Town T. Characterization of cancer stem cells and primary cilia in medulloblastoma. Cns & Neurological Disorders Drug Targets. 14: 600-11. PMID 25921740  0.56
2015 Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, ... ... Town T, et al. Neuroinflammation in Alzheimer's disease. The Lancet. Neurology. 14: 388-405. PMID 25792098 DOI: 10.1016/S1474-4422(15)70016-5  0.72
2015 Stratigi K, Kapsetaki M, Aivaliotis M, Town T, Flavell RA, Spilianakis CG. Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expression. Proceedings of the National Academy of Sciences of the United States of America. 112: E1577-86. PMID 25770217 DOI: 10.1073/pnas.1502182112  0.72
2015 Guillot-Sestier MV, Doty KR, Gate D, Rodriguez J, Leung BP, Rezai-Zadeh K, Town T. Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology. Neuron. 85: 534-48. PMID 25619654 DOI: 10.1016/j.neuron.2014.12.068  0.72
2015 Doty KR, Guillot-Sestier MV, Town T. The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive? Brain Research. 1617: 155-73. PMID 25218556 DOI: 10.1016/j.brainres.2014.09.008  0.72
2014 Weitz TM, Gate D, Rezai-Zadeh K, Town T. MyD88 is dispensable for cerebral amyloidosis and neuroinflammation in APP/PS1 transgenic mice. The American Journal of Pathology. 184: 2855-61. PMID 25174876 DOI: 10.1016/j.ajpath.2014.07.004  0.72
2014 Mori T, Koyama N, Segawa T, Maeda M, Maruyama N, Kinoshita N, Hou H, Tan J, Town T. Methylene blue modulates β-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice. The Journal of Biological Chemistry. 289: 30303-17. PMID 25157105 DOI: 10.1074/jbc.M114.568212  0.6
2014 Gate D, Danielpour M, Rodriguez J, Kim GB, Levy R, Bannykh S, Breunig JJ, Kaech SM, Flavell RA, Town T. T-cell TGF-β signaling abrogation restricts medulloblastoma progression. Proceedings of the National Academy of Sciences of the United States of America. 111: E3458-66. PMID 25082897 DOI: 10.1073/pnas.1412489111  0.72
2014 Mott KR, Allen SJ, Zandian M, Konda B, Sharifi BG, Jones C, Wechsler SL, Town T, Ghiasi H. CD8α dendritic cells drive establishment of HSV-1 latency. Plos One. 9: e93444. PMID 24695322 DOI: 10.1371/journal.pone.0093444  0.72
2013 Breunig JJ, Guillot-Sestier MV, Town T. Brain injury, neuroinflammation and Alzheimer's disease. Frontiers in Aging Neuroscience. 5: 26. PMID 23874297 DOI: 10.3389/fnagi.2013.00026  0.72
2013 Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe CG, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG, Kepe V, Barrio JR, ... ... Town T, et al. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 6245-56. PMID 23575824 DOI: 10.1523/JNEUROSCI.3672-12.2013  0.72
2013 Guillot-Sestier MV, Town T. Innate immunity in Alzheimer's disease: a complex affair. Cns & Neurological Disorders Drug Targets. 12: 593-607. PMID 23574177  0.56
2013 Biancotti JC, Town T. Increasing hematopoietic stem cell yield to develop mice with human immune systems. Biomed Research International. 2013: 740892. PMID 23509770 DOI: 10.1155/2013/740892  0.36
2013 Mori T, Koyama N, Guillot-Sestier MV, Tan J, Town T. Ferulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice. Plos One. 8: e55774. PMID 23409038 DOI: 10.1371/journal.pone.0055774  0.6
2012 Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E. IL-22 signaling contributes to West Nile encephalitis pathogenesis. Plos One. 7: e44153. PMID 22952908 DOI: 10.1371/journal.pone.0044153  0.72
2012 Weitz TM, Town T. Microglia in Alzheimer's Disease: It's All About Context. International Journal of Alzheimer's Disease. 2012: 314185. PMID 22779026 DOI: 10.1155/2012/314185  0.72
2012 Breunig JJ, Gate D, Levy R, Rodriguez J, Kim GB, Danielpour M, Svendsen CN, Town T. Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation. Neural Development. 7: 26. PMID 22776033 DOI: 10.1186/1749-8104-7-26  0.72
2012 Gate D, Danielpour M, Levy R, Breunig JJ, Town T. Basic biology and mechanisms of neural ciliogenesis and the B9 family. Molecular Neurobiology. 45: 564-70. PMID 22644387 DOI: 10.1007/s12035-012-8276-7  0.72
2012 Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, ... ... Town T, et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. 36: 401-14. PMID 22342844 DOI: 10.1016/j.immuni.2012.01.009  0.72
2012 Mori T, Rezai-Zadeh K, Koyama N, Arendash GW, Yamaguchi H, Kakuda N, Horikoshi-Sakuraba Y, Tan J, Town T. Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice. The Journal of Biological Chemistry. 287: 6912-27. PMID 22219198 DOI: 10.1074/jbc.M111.294025  0.72
2011 Gray P, Dagvadorj J, Michelsen KS, Brikos C, Rentsendorj A, Town T, Crother TR, Arditi M. Myeloid differentiation factor-2 interacts with Lyn kinase and is tyrosine phosphorylated following lipopolysaccharide-induced activation of the TLR4 signaling pathway. Journal of Immunology (Baltimore, Md. : 1950). 187: 4331-7. PMID 21918188 DOI: 10.4049/jimmunol.1100890  0.56
2011 Allen SJ, Mott KR, Wechsler SL, Flavell RA, Town T, Ghiasi H. Adaptive and innate transforming growth factor beta signaling impact herpes simplex virus 1 latency and reactivation. Journal of Virology. 85: 11448-56. PMID 21880769 DOI: 10.1128/JVI.00678-11  0.72
2011 Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, et al. Control of TH17 cells occurs in the small intestine. Nature. 475: 514-8. PMID 21765430 DOI: 10.1038/nature10228  0.72
2011 Rezai-Zadeh K, Gate D, Gowing G, Town T. How to get from here to there: macrophage recruitment in Alzheimer's disease. Current Alzheimer Research. 8: 156-63. PMID 21345166  0.72
2011 Allen SJ, Hamrah P, Gate D, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, BenMohamed L, Ahmed R, Wechsler SL, Ghiasi H. The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. Journal of Virology. 85: 4184-97. PMID 21307196 DOI: 10.1128/JVI.02290-10  0.72
2011 Zhu Y, Hou H, Rezai-Zadeh K, Giunta B, Ruscin A, Gemma C, Jin J, Dragicevic N, Bradshaw P, Rasool S, Glabe CG, Ehrhart J, Bickford P, Mori T, Obregon D, ... Town T, et al. CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1355-65. PMID 21273420 DOI: 10.1523/JNEUROSCI.3268-10.2011  0.72
2011 Mott KR, Gate D, Zandian M, Allen SJ, Rajasagi NK, van Rooijen N, Chen S, Arditi M, Rouse BT, Flavell RA, Town T, Ghiasi H. Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs. Investigative Ophthalmology & Visual Science. 52: 2321-33. PMID 21220560 DOI: 10.1167/iovs.10-6536  0.72
2011 Zhu Y, Obregon D, Hou H, Giunta B, Ehrhart J, Fernandez F, Mori T, Nikolic W, Zhao Y, Morgan D, Town T, Tan J. Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology. Journal of Cellular and Molecular Medicine. 15: 327-38. PMID 19900216 DOI: 10.1111/j.1582-4934.2009.00962.x  0.72
2010 Mori T, Asano T, Town T. Targeting S100B in Cerebral Ischemia and in Alzheimer's Disease. Cardiovascular Psychiatry and Neurology. 2010. PMID 20862385 DOI: 10.1155/2010/687067  0.4
2010 Gate D, Rezai-Zadeh K, Jodry D, Rentsendorj A, Town T. Macrophages in Alzheimer's disease: the blood-borne identity. Journal of Neural Transmission (Vienna, Austria : 1996). 117: 961-70. PMID 20517700 DOI: 10.1007/s00702-010-0422-7  0.72
2010 Town T. Alzheimer's Disease Beyond Abeta. Expert Review of Neurotherapeutics. 10: 671-5. PMID 20429127 DOI: 10.1586/ern.10.50  0.6
2010 Town T. Inflammation, immunity, and Alzheimer's disease. Cns & Neurological Disorders Drug Targets. 9: 129-31. PMID 20205648  0.6
2010 Mori T, Koyama N, Arendash GW, Horikoshi-Sakuraba Y, Tan J, Town T. Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease. Glia. 58: 300-14. PMID 19705461 DOI: 10.1002/glia.20924  0.72
2009 Rezai-Zadeh K, Gate D, Szekely CA, Town T. Can peripheral leukocytes be used as Alzheimer's disease biomarkers? Expert Review of Neurotherapeutics. 9: 1623-33. PMID 19903022 DOI: 10.1586/ern.09.118  0.72
2009 Bai F, Town T, Qian F, Wang P, Kamanaka M, Connolly TM, Gate D, Montgomery RR, Flavell RA, Fikrig E. IL-10 signaling blockade controls murine West Nile virus infection. Plos Pathogens. 5: e1000610. PMID 19816558 DOI: 10.1371/journal.ppat.1000610  0.72
2009 Giunta B, Figueroa KP, Town T, Tan J. SOLUBLE CD40 LIGAND IN DEMENTIA. Drugs of the Future. 34: 333-340. PMID 19777117 DOI: 10.1358/dof.2009.034.04.1358595  0.6
2009 Rezai-Zadeh K, Gate D, Town T. CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease? Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 462-75. PMID 19669892 DOI: 10.1007/s11481-009-9166-2  0.72
2009 O'Connor W, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, Kolls JK, Flavell RA. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nature Immunology. 10: 603-9. PMID 19448631 DOI: 10.1038/ni.1736  0.72
2009 Mott KR, Underhill D, Wechsler SL, Town T, Ghiasi H. A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages. Virology Journal. 6: 56. PMID 19439086 DOI: 10.1186/1743-422X-6-56  0.72
2009 Town T. Alternative Abeta immunotherapy approaches for Alzheimer's disease. Cns & Neurological Disorders Drug Targets. 8: 114-27. PMID 19355932 DOI: 10.2174/187152709787847306  0.56
2009 Town T, Bai F, Wang T, Kaplan AT, Qian F, Montgomery RR, Anderson JF, Flavell RA, Fikrig E. Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity. 30: 242-53. PMID 19200759 DOI: 10.1016/j.immuni.2008.11.012  0.72
2009 Rezai-Zadeh K, Douglas Shytle R, Bai Y, Tian J, Hou H, Mori T, Zeng J, Obregon D, Town T, Tan J. Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production. Journal of Cellular and Molecular Medicine. 13: 574-88. PMID 18410522 DOI: 10.1111/j.1582-4934.2008.00344.x  0.72
2008 Giunta B, Fernandez F, Nikolic WV, Obregon D, Rrapo E, Town T, Tan J. Inflammaging as a prodrome to Alzheimer's disease. Journal of Neuroinflammation. 5: 51. PMID 19014446 DOI: 10.1186/1742-2094-5-51  0.72
2008 Breunig JJ, Sarkisian MR, Arellano JI, Morozov YM, Ayoub AE, Sojitra S, Wang B, Flavell RA, Rakic P, Town T. Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proceedings of the National Academy of Sciences of the United States of America. 105: 13127-32. PMID 18728187 DOI: 10.1073/pnas.0804558105  0.72
2008 Laouar Y, Town T, Jeng D, Tran E, Wan Y, Kuchroo VK, Flavell RA. TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America. 105: 10865-70. PMID 18669656 DOI: 10.1073/pnas.0805058105  0.72
2008 Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, Wang T. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 181: 2084-91. PMID 18641347  0.72
2008 Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS, Flavell RA. Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nature Medicine. 14: 681-7. PMID 18516051 DOI: 10.1038/nm1781  0.72
2008 Mori T, Tan J, Arendash GW, Koyama N, Nojima Y, Town T. Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemia. Stroke; a Journal of Cerebral Circulation. 39: 2114-21. PMID 18451356 DOI: 10.1161/STROKEAHA.107.503821  0.72
2008 Mohanty S, Town T, Yagi T, Scheidig C, Kwan KY, Allore HG, Flavell RA, Shaw AC. Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta. Proceedings of the National Academy of Sciences of the United States of America. 105: 5063-8. PMID 18367668 DOI: 10.1073/pnas.0801235105  0.72
2008 Nikolic WV, Hou H, Town T, Zhu Y, Giunta B, Sanberg CD, Zeng J, Luo D, Ehrhart J, Mori T, Sanberg PR, Tan J. Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice. Stem Cells and Development. 17: 423-39. PMID 18366296 DOI: 10.1089/scd.2008.0018  0.72
2008 Town T, Breunig JJ, Sarkisian MR, Spilianakis C, Ayoub AE, Liu X, Ferrandino AF, Gallagher AR, Li MO, Rakic P, Flavell RA. The stumpy gene is required for mammalian ciliogenesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 2853-8. PMID 18287022 DOI: 10.1073/pnas.0712385105  0.72
2008 Dai J, Wang P, Bai F, Town T, Fikrig E. Icam-1 participates in the entry of west nile virus into the central nervous system. Journal of Virology. 82: 4164-8. PMID 18256150 DOI: 10.1128/JVI.02621-07  0.72
2008 Obregon D, Hou H, Bai Y, Nikolic WV, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T, Tan J. CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation. Neurobiology of Disease. 29: 336-53. PMID 18055209 DOI: 10.1016/j.nbd.2007.09.009  0.72
2007 Arjona A, Ledizet M, Anthony K, Bonafé N, Modis Y, Town T, Fikrig E. West Nile virus envelope protein inhibits dsRNA-induced innate immune responses. Journal of Immunology (Baltimore, Md. : 1950). 179: 8403-9. PMID 18056386  0.72
2007 Deane JA, Pisitkun P, Barrett RS, Feigenbaum L, Town T, Ward JM, Flavell RA, Bolland S. Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity. 27: 801-10. PMID 17997333 DOI: 10.1016/j.immuni.2007.09.009  0.72
2007 Arjona A, Foellmer HG, Town T, Leng L, McDonald C, Wang T, Wong SJ, Montgomery RR, Fikrig E, Bucala R. Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. The Journal of Clinical Investigation. 117: 3059-66. PMID 17909632 DOI: 10.1172/JCI32218  0.72
2007 Watanabe A, Hashmi A, Gomes DA, Town T, Badou A, Flavell RA, Mehal WZ. Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9. Hepatology (Baltimore, Md.). 46: 1509-18. PMID 17705260 DOI: 10.1002/hep.21867  0.72
2007 Szekely CA, Town T, Zandi PP. NSAIDs for the chemoprevention of Alzheimer's disease. Sub-Cellular Biochemistry. 42: 229-48. PMID 17612054  0.72
2007 Nikolic WV, Bai Y, Obregon D, Hou H, Mori T, Zeng J, Ehrhart J, Shytle RD, Giunta B, Morgan D, Town T, Tan J. Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage. Proceedings of the National Academy of Sciences of the United States of America. 104: 2507-12. PMID 17264212 DOI: 10.1073/pnas.0609377104  0.72
2007 Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E. Antiviral peptides targeting the west nile virus envelope protein. Journal of Virology. 81: 2047-55. PMID 17151121 DOI: 10.1128/JVI.01840-06  0.72
2006 Wang R, Town T, Gokarn V, Flavell RA, Chandawarkar RY. HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways. The Journal of Surgical Research. 136: 58-69. PMID 16979664 DOI: 10.1016/j.jss.2006.06.003  0.72
2006 Mori T, Town T, Tan J, Yada N, Horikoshi Y, Yamamoto J, Shimoda T, Kamanaka Y, Tateishi N, Asano T. Arundic Acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice. The Journal of Pharmacology and Experimental Therapeutics. 318: 571-8. PMID 16709678 DOI: 10.1124/jpet.106.105171  0.6
2006 Obregon DF, Rezai-Zadeh K, Bai Y, Sun N, Hou H, Ehrhart J, Zeng J, Mori T, Arendash GW, Shytle D, Town T, Tan J. ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein. The Journal of Biological Chemistry. 281: 16419-27. PMID 16624814 DOI: 10.1074/jbc.M600617200  0.72
2006 Town T, Jeng D, Alexopoulou L, Tan J, Flavell RA. Microglia recognize double-stranded RNA via TLR3. Journal of Immunology (Baltimore, Md. : 1950). 176: 3804-12. PMID 16517751  0.72
2006 Harris JR, Almouzni G, Kirschner D, Dimitrova D, Nickerson JA, Underwood J, Wagner S, Korbei B, Foisner R, Walther TC, Hetzer M, Peters R, Walev I, de Kroon AIPM, Staffhorst RWHM, ... ... Town T, et al. In Vitro Techniques Cell Biology Protocols. 201-378. DOI: 10.1002/0470033487.ch6  0.72
2005 Town T, Nikolic V, Tan J. The microglial "activation" continuum: from innate to adaptive responses. Journal of Neuroinflammation. 2: 24. PMID 16259628 DOI: 10.1186/1742-2094-2-24  0.6
2005 Town T, Tan J, Flavell RA, Mullan M. T-cells in Alzheimer's disease. Neuromolecular Medicine. 7: 255-64. PMID 16247185 DOI: 10.1385/NMM:7:3:255  0.72
2005 Rezai-Zadeh K, Shytle D, Sun N, Mori T, Hou H, Jeanniton D, Ehrhart J, Townsend K, Zeng J, Morgan D, Hardy J, Town T, Tan J. Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8807-14. PMID 16177050 DOI: 10.1523/JNEUROSCI.1521-05.2005  0.72
2005 Kimberly WT, Zheng JB, Town T, Flavell RA, Selkoe DJ. Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5533-43. PMID 15944381 DOI: 10.1523/JNEUROSCI.4883-04.2005  0.72
2005 Spilianakis CG, Lalioti MD, Town T, Lee GR, Flavell RA. Interchromosomal associations between alternatively expressed loci. Nature. 435: 637-45. PMID 15880101 DOI: 10.1038/nature03574  0.72
2005 Mori T, Town T, Tan J, Tateishi N, Asano T. Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 isoform after permanent focal ischemia in apolipoprotein E knock-in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 25: 748-62. PMID 15689951 DOI: 10.1038/sj.jcbfm.9600063  0.6
2005 Townsend KP, Town T, Mori T, Lue LF, Shytle D, Sanberg PR, Morgan D, Fernandez F, Flavell RA, Tan J. CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide. European Journal of Immunology. 35: 901-10. PMID 15688347 DOI: 10.1002/eji.200425585  0.72
2004 Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nature Medicine. 10: 1366-73. PMID 15558055 DOI: 10.1038/nm1140  0.72
2004 Todd Roach J, Volmar CH, Dwivedi S, Town T, Crescentini R, Crawford F, Tan J, Mullan M. Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice. Brain Research. 1015: 161-8. PMID 15223380 DOI: 10.1016/j.brainres.2004.05.004  0.72
2004 Mori T, Town T, Kobayashi M, Tan J, Fujita SC, Asano T. Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 24: 646-56. PMID 15181372 DOI: 10.1097/01.WCB.0000120787.53851.A4  0.6
2004 Townsend KP, Vendrame M, Ehrhart J, Faza B, Zeng J, Town T, Tan J. CD45 isoform RB as a molecular target to oppose lipopolysaccharide-induced microglial activation in mice. Neuroscience Letters. 362: 26-30. PMID 15147773 DOI: 10.1016/j.neulet.2004.01.082  0.72
2004 Mott RT, Ait-Ghezala G, Town T, Mori T, Vendrame M, Zeng J, Ehrhart J, Mullan M, Tan J. Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production. Glia. 46: 369-79. PMID 15095367 DOI: 10.1002/glia.20009  0.72
2003 Mori T, Kobayashi M, Town T, Fujita SC, Asano T. Increased vulnerability to focal ischemic brain injury in human apolipoprotein E4 knock-in mice. Journal of Neuropathology and Experimental Neurology. 62: 280-91. PMID 12638732  0.4
2002 Tan J, Town T, Abdullah L, Wu Y, Placzek A, Small B, Kroeger J, Crawford F, Richards D, Mullan M. CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease. Journal of Neuroimmunology. 132: 164-72. PMID 12417447 DOI: 10.1016/S0165-5728(02)00309-0  0.72
2002 Town T, Vendrame M, Patel A, Poetter D, DelleDonne A, Mori T, Smeed R, Crawford F, Klein T, Tan J, Mullan M. Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's beta-amyloid(1-42). Journal of Neuroimmunology. 132: 49-59. PMID 12417433 DOI: 10.1016/S0165-5728(02)00307-7  0.72
2002 Tan J, Town T, Crawford F, Mori T, DelleDonne A, Crescentini R, Obregon D, Flavell RA, Mullan MJ. Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nature Neuroscience. 5: 1288-93. PMID 12402041 DOI: 10.1038/nn968  0.72
2002 Tan J, Town T, Mullan M. CD40-CD40L interaction in Alzheimer's disease. Current Opinion in Pharmacology. 2: 445-51. PMID 12127879 DOI: 10.1016/S1471-4892(02)00180-7  0.72
2002 Town T, Zolton J, Shaffner R, Schnell B, Crescentini R, Wu Y, Zeng J, DelleDonne A, Obregon D, Tan J, Mullan M. p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro. Journal of Neuroscience Research. 69: 362-72. PMID 12125077 DOI: 10.1002/jnr.10299  0.72
2002 Ait-Ghezala G, Abdullah L, Crescentini R, Crawford F, Town T, Singh S, Richards D, Duara R, Mullan M. Confirmation of association between D10S583 and Alzheimer's disease in a case--control sample. Neuroscience Letters. 325: 87-90. PMID 12044628 DOI: 10.1016/S0304-3940(02)00243-4  0.72
2002 Tan J, Town T, Mori T, Obregon D, Wu Y, DelleDonne A, Rojiani A, Crawford F, Flavell RA, Mullan M. CD40 is expressed and functional on neuronal cells. The Embo Journal. 21: 643-52. PMID 11847112 DOI: 10.1093/emboj/21.4.643  0.72
2002 Schinka JA, Town T, Abdullah L, Crawford FC, Ordorica PI, Francis E, Hughes P, Graves AB, Mortimer JA, Mullan M. A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances. Molecular Psychiatry. 7: 224-8. PMID 11840318 DOI: 10.1038/sj.mp.4000951  0.72
2001 Town T, Tan J, Mullan M. CD40 signaling and Alzheimer's disease pathogenesis. Neurochemistry International. 39: 371-80. PMID 11578772 DOI: 10.1016/S0197-0186(01)00044-4  0.72
2001 Mori T, Paris D, Town T, Rojiani AM, Sparks DL, Delledonne A, Crawford F, Abdullah LI, Humphrey JA, Dickson DW, Mullan MJ. Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice. Journal of Neuropathology and Experimental Neurology. 60: 778-85. PMID 11487052  0.72
2001 Town T, Tan J, Sansone N, Obregon D, Klein T, Mullan M. Characterization of murine immunoglobulin G antibodies against human amyloid-beta1-42. Neuroscience Letters. 307: 101-4. PMID 11427310 DOI: 10.1016/S0304-3940(01)01951-6  0.72
2001 Mori T, Nagata K, Town T, Tan J, Matsui T, Asano T. Intracisternal increase of superoxide anion production in a canine subarachnoid hemorrhage model. Stroke; a Journal of Cerebral Circulation. 32: 636-42. PMID 11239179  0.6
2000 Town T, Schinka J, Tan J, Mullan M. The opioid receptor system and alcoholism: a genetic perspective. European Journal of Pharmacology. 410: 243-248. PMID 11134673 DOI: 10.1016/S0014-2999(00)00818-9  0.72
2000 Tan J, Town T, Mori T, Wu Y, Saxe M, Crawford F, Mullan M. CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7587-94. PMID 11027218  0.72
2000 Tan J, Town T, Mullan M. CD45 inhibits CD40L-induced microglial activation via negative regulation of the Src/p44/42 MAPK pathway. The Journal of Biological Chemistry. 275: 37224-31. PMID 10978311 DOI: 10.1074/jbc.M002006200  0.72
2000 Paris D, Town T, Humphrey J, Yokota K, Mullan M. Cholesterol modulates vascular reactivity to endothelin-1 by stimulating a pro-inflammatory pathway. Biochemical and Biophysical Research Communications. 274: 553-8. PMID 10913376 DOI: 10.1006/bbrc.2000.3174  0.72
2000 Paris D, Town T, Mori T, Parker TA, Humphrey J, Mullan M. Soluble beta-amyloid peptides mediate vasoactivity via activation of a pro-inflammatory pathway. Neurobiology of Aging. 21: 183-97. PMID 10867203 DOI: 10.1016/S0197-4580(99)00111-6  0.72
2000 Paris D, Town T, Parker T, Humphrey J, Mullan M. beta-Amyloid vasoactivity and proinflammation in microglia can be blocked by cGMP-elevating agents. Annals of the New York Academy of Sciences. 903: 446-50. PMID 10818536  0.72
2000 Paris D, Town T, Parker T, Humphrey J, Mullan M. A beta vasoactivity: an inflammatory reaction. Annals of the New York Academy of Sciences. 903: 97-109. PMID 10818494 DOI: 10.1111/j.1749-6632.2000.tb06355.x  0.72
2000 Paris D, Town T, Mullan M. Novel strategies for opposing murine microglial activation. Neuroscience Letters. 278: 5-8. PMID 10643787 DOI: 10.1016/S0304-3940(99)00901-5  0.72
1999 Tan J, Town T, Paris D, Mori T, Suo Z, Crawford F, Mattson MP, Flavell RA, Mullan M. Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. Science (New York, N.Y.). 286: 2352-5. PMID 10600748 DOI: 10.1126/science.286.5448.2352  0.72
1999 Tan J, Town T, Saxe M, Paris D, Wu Y, Mullan M. Ligation of microglial CD40 results in p44/42 mitogen-activated protein kinase-dependent TNF-alpha production that is opposed by TGF-beta 1 and IL-10. Journal of Immunology (Baltimore, Md. : 1950). 163: 6614-21. PMID 10586056  0.72
1999 Tan J, Town T, Suo Z, Wu Y, Song S, Kundtz A, Kroeger J, Humphrey J, Crawford F, Mullan M. Induction of CD40 on human endothelial cells by Alzheimer's beta-amyloid peptides. Brain Research Bulletin. 50: 143-8. PMID 10535333 DOI: 10.1016/S0361-9230(99)00122-7  0.72
1999 Tan J, Town T, Placzek A, Kundtz A, Yu H, Mullan M. Bcl-X(L) inhibits apoptosis and necrosis produced by Alzheimer's beta-amyloid1-40 peptide in PC12 cells. Neuroscience Letters. 272: 5-8. PMID 10507529 DOI: 10.1016/S0304-3940(99)00525-X  0.68
1999 Town T, Paris D, Parker TA, Kundtz A, Tan J, Duara R, Gold M, Crawford F, Mullan M. Alzheimers disease is not associated with the hypertension genetic risk factors PLA(2) or G protein beta3, either independently or interactively with apolipoprotein E. American Journal of Medical Genetics. 88: 465-8. PMID 10490699 DOI: 10.1002/(SICI)1096-8628(19991015)88:5<465::AID-AJMG5>3.0.CO;2-M  0.72
1999 Town T, Abdullah L, Crawford F, Schinka J, Ordorica PI, Francis E, Hughes P, Duara R, Mullan M. Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency. American Journal of Medical Genetics. 88: 458-61. PMID 10490697 DOI: 10.1002/(SICI)1096-8628(19991015)88:5<458::AID-AJMG3>3.0.CO;2-S  0.72
1999 Crawford F, Freeman M, Town T, Fallin D, Gold M, Duara R, Mullan M. No genetic association between polymorphisms in the Tau gene and Alzheimer's disease in clinic or population based samples. Neuroscience Letters. 266: 193-6. PMID 10465706 DOI: 10.1016/S0304-3940(99)00303-1  0.72
1999 Crawford F, Town T, Freeman M, Schinka J, Gold M, Duara R, Mullan M. The alpha-2 macroglobulin gene is not associated with Alzheimer's disease in a case-control sample. Neuroscience Letters. 270: 133-6. PMID 10462112 DOI: 10.1016/S0304-3940(99)00470-X  0.72
1999 Tan J, Town T, Paris D, Placzek A, Parker T, Crawford F, Yu H, Humphrey J, Mullan M. Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis. Journal of Neuroimmunology. 97: 77-85. PMID 10408982 DOI: 10.1016/S0165-5728(99)00053-3  0.72
1999 Paris D, Town T, Parker TA, Tan J, Humphrey J, Crawford F, Mullan M. Inhibition of Alzheimer's beta-amyloid induced vasoactivity and proinflammatory response in microglia by a cGMP-dependent mechanism. Experimental Neurology. 157: 211-21. PMID 10222124 DOI: 10.1006/exnr.1999.7055  0.72
1998 Paris D, Town T, Parker TA, Humphrey J, Mullan M. Isoform-specific vasoconstriction induced by apolipoprotein E and modulation of this effect by Alzheimer's beta-amyloid peptide. Neuroscience Letters. 256: 73-6. PMID 9853706  0.68
1998 Town T, Paris D, Fallin D, Duara R, Barker W, Gold M, Crawford F, Mullan M. The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism. Neuroscience Letters. 252: 95-8. PMID 9756330 DOI: 10.1016/S0304-3940(98)00567-9  0.72
1998 Paris D, Parker TA, Town T, Suo Z, Fang C, Humphrey J, Crawford F, Mullan M. Role of peroxynitrite in the vasoactive and cytotoxic effects of Alzheimer's beta-amyloid1-40 peptide. Experimental Neurology. 152: 116-22. PMID 9682018 DOI: 10.1006/exnr.1998.6828  0.72
1997 Fallin D, Kundtz A, Town T, Gauntlett AC, Duara R, Barker W, Crawford F, Mullan M. No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample. Neuroscience Letters. 233: 145-7. PMID 9350853 DOI: 10.1016/S0304-3940(97)00634-4  0.72
1997 Town T, Fallin D, Crawford F, Walsh S, Solomon R, Mullan M. Lack of association between the apolipoprotein E epsilon4 allele (APOE epsilon4) and chronic schizophrenia. American Journal of Medical Genetics. 74: 451-2. PMID 9259385 DOI: 10.1002/(SICI)1096-8628(19970725)74:4<451::AID-AJMG20>3.0.CO;2-G  0.68
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