Marco Bortolato, MD, PhD - Publications

Affiliations: 
Pharmacology and Toxicology University of Kansas, Lawrence, KS, United States 
Area:
Behavioral Neuroscience, dopamine, neurosteroids, aggression, Tourette syndrome, schizophrenia, autism

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Godar SC, Mosher LJ, Scheggi S, Devoto P, Moench KM, Strathman HJ, Jones CM, Frau R, Melis M, Gambarana C, Wilkinson B, DeMontis MG, Fowler SC, Coba MP, Wellman CL, ... ... Bortolato M, et al. Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT receptor activation. Neuropharmacology. PMID 30716416 DOI: 10.1016/j.neuropharm.2019.01.028  0.36
2018 Mosher LJ, Godar SC, Morissette M, McFarlin KM, Scheggi S, Gambarana C, Fowler SC, Di Paolo T, Bortolato M. Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors. Psychoneuroendocrinology. 91: 95-104. PMID 29544191 DOI: 10.1016/j.psyneuen.2018.02.007  0.36
2017 Jarmolowicz DP, Hudnall JL, Hale L, Fowler SC, Bortolato M, Lemley SM, Sofis MJ. Delay discounting as impaired valuation: Delayed rewards in an animal obesity model. Journal of the Experimental Analysis of Behavior. 108: 171-183. PMID 28940395 DOI: 10.1002/jeab.275  0.36
2017 Mosher LJ, Godar SC, Nelson M, Fowler SC, Pinna G, Bortolato M. Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models. Scientific Reports. 7: 3348. PMID 28611376 DOI: 10.1038/s41598-017-03649-1  0.36
2017 Fowler SC, Mosher LJ, Godar SC, Bortolato M. Assessment of gait and sensorimotor deficits in the D1CT-7 mouse model of Tourette syndrome. Journal of Neuroscience Methods. PMID 28099872 DOI: 10.1016/j.jneumeth.2017.01.009  0.36
2016 Pes R, Godar SC, Fox AT, Burgeno LM, Strathman HJ, Jarmolowicz DP, Devoto P, Levant B, Phillips PE, Fowler SC, Bortolato M. Pramipexole enhances disadvantageous decision-making: Lack of relation to changes in phasic dopamine release. Neuropharmacology. PMID 27889491 DOI: 10.1016/j.neuropharm.2016.11.014  0.36
2016 Godar SC, Fite PJ, McFarlin KM, Bortolato M. The role of monoamine oxidase a in aggression: Current translational developments and future challenges. Progress in Neuro-Psychopharmacology & Biological Psychiatry. PMID 26776902 DOI: 10.1016/j.pnpbp.2016.01.001  0.44
2016 Brown S, Fite PJ, Stone K, Bortolato M. Accounting for the associations between child maltreatment and internalizing problems: The role of alexithymia. Child Abuse & Neglect. 52: 20-28. PMID 26774529 DOI: 10.1016/j.chiabu.2015.12.008  0.44
2016 Frau R, Mosher LJ, Bini V, Pillolla G, Pes R, Saba P, Fanni S, Devoto P, Bortolato M. The neurosteroidogenic enzyme 5α-reductase modulates the role of D1 dopamine receptors in rat sensorimotor gating. Psychoneuroendocrinology. 63: 59-67. PMID 26415119 DOI: 10.1016/j.psyneuen.2015.09.014  0.44
2015 Godar SC, Mosher LJ, Strathman HJ, Gochi AM, Jones CM, Fowler SC, Bortolato M. The D1CT-7 mouse model of Tourette syndrome displays sensorimotor gating deficits in response to spatial confinement. British Journal of Pharmacology. PMID 26171666 DOI: 10.1111/bph.13243  0.44
2015 Mosher LJ, Frau R, Pardu A, Pes R, Devoto P, Bortolato M. Selective activation of D1 dopamine receptors impairs sensorimotor gating in Long-Evans rats. British Journal of Pharmacology. PMID 26101934 DOI: 10.1111/bph.13232  0.44
2015 Godar SC, Bortolato M, Richards SE, Li FG, Chen K, Wellman CL, Shih JC. Monoamine Oxidase A is Required for Rapid Dendritic Remodeling in Response to Stress. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 18. PMID 25857821 DOI: 10.1093/ijnp/pyv035  0.44
2015 Moskovitz J, Walss-Bass C, Cruz DA, Thompson PM, Hairston J, Bortolato M. The enzymatic activities of brain catechol-O-methyltransferase (COMT) and methionine sulphoxide reductase are correlated in a COMT Val/Met allele-dependent fashion. Neuropathology and Applied Neurobiology. PMID 25640985 DOI: 10.1111/nan.12219  0.44
2014 Godar SC, Mosher LJ, Di Giovanni G, Bortolato M. Animal models of tic disorders: a translational perspective. Journal of Neuroscience Methods. 238: 54-69. PMID 25244952 DOI: 10.1016/j.jneumeth.2014.09.008  0.44
2014 Stetler DA, Davis C, Leavitt K, Schriger I, Benson K, Bhakta S, Wang LC, Oben C, Watters M, Haghnegahdar T, Bortolato M. Association of low-activity MAOA allelic variants with violent crime in incarcerated offenders. Journal of Psychiatric Research. 58: 69-75. PMID 25082653 DOI: 10.1016/j.jpsychires.2014.07.006  0.44
2014 Godar SC, Bortolato M, Castelli MP, Casti A, Casu A, Chen K, Ennas MG, Tambaro S, Shih JC. The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake. Journal of Psychiatric Research. 56: 1-9. PMID 24882701 DOI: 10.1016/j.jpsychires.2014.04.014  0.44
2014 Moskovitz J, Walss-Bass C, Cruz DA, Thompson PM, Bortolato M. Methionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 17: 1707-13. PMID 24735585 DOI: 10.1017/S1461145714000467  0.44
2014 Frau R, Bini V, Pillolla G, Malherbe P, Pardu A, Thomas AW, Devoto P, Bortolato M. Positive allosteric modulation of GABAB receptors ameliorates sensorimotor gating in rodent models. Cns Neuroscience & Therapeutics. 20: 679-84. PMID 24703381 DOI: 10.1111/cns.12261  0.44
2014 Godar SC, Bortolato M. Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission. Frontiers in Behavioral Neuroscience. 8: 71. PMID 24639636 DOI: 10.3389/fnbeh.2014.00071  0.44
2014 Frau R, Bini V, Pes R, Pillolla G, Saba P, Devoto P, Bortolato M. Inhibition of 17α-hydroxylase/C17,20 lyase reduces gating deficits consequent to dopaminergic activation. Psychoneuroendocrinology. 39: 204-13. PMID 24140269 DOI: 10.1016/j.psyneuen.2013.09.014  0.36
2013 Bortolato M, Godar SC, Tambaro S, Li FG, Devoto P, Coba MP, Chen K, Shih JC. Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice. Neuropharmacology. 75: 223-32. PMID 23871843 DOI: 10.1016/j.neuropharm.2013.07.003  0.44
2013 Singh C, Bortolato M, Bali N, Godar SC, Scott AL, Chen K, Thompson RF, Shih JC. Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 110: 12816-21. PMID 23858446 DOI: 10.1073/pnas.1308037110  0.44
2013 Bortolato M, Frau R, Godar SC, Mosher LJ, Paba S, Marrosu F, Devoto P. The implication of neuroactive steroids in Tourette's syndrome pathogenesis: A role for 5α-reductase? Journal of Neuroendocrinology. 25: 1196-208. PMID 23795653 DOI: 10.1111/jne.12066  0.44
2013 Davis DA, Bortolato M, Godar SC, Sander TK, Iwata N, Pakbin P, Shih JC, Berhane K, McConnell R, Sioutas C, Finch CE, Morgan TE. Prenatal exposure to urban air nanoparticles in mice causes altered neuronal differentiation and depression-like responses. Plos One. 8: e64128. PMID 23734187 DOI: 10.1371/journal.pone.0064128  0.44
2013 Wyatt LR, Godar SC, Khoja S, Jakowec MW, Alkana RL, Bortolato M, Davies DL. Sociocommunicative and sensorimotor impairments in male P2X4-deficient mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 1993-2002. PMID 23604007 DOI: 10.1038/npp.2013.98  0.44
2013 Bortolato M, Yardley MM, Khoja S, Godar SC, Asatryan L, Finn DA, Alkana RL, Louie SG, Davies DL. Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 1059-70. PMID 23174033 DOI: 10.1017/S1461145712000909  0.44
2013 Stancampiano R, Frau R, Bini V, Collu M, Carta M, Fadda F, Bortolato M. Chronic tryptophan deprivation attenuates gating deficits induced by 5-HT(1A), but not 5-HTâ‚‚ receptor activation. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 1329-35. PMID 23141373 DOI: 10.1016/j.euroneuro.2012.10.009  0.44
2013 Bortolato M, Godar SC, Alzghoul L, Zhang J, Darling RD, Simpson KL, Bini V, Chen K, Wellman CL, Lin RC, Shih JC. Monoamine oxidase A and A/B knockout mice display autistic-like features. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 869-88. PMID 22850464 DOI: 10.1017/S1461145712000715  0.44
2013 Castelli MP, Casti A, Casu A, Frau R, Bortolato M, Spiga S, Ennas MG. Regional distribution of 5α-reductase type 2 in the adult rat brain: an immunohistochemical analysis. Psychoneuroendocrinology. 38: 281-93. PMID 22776423 DOI: 10.1016/j.psyneuen.2012.06.008  0.44
2013 Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW. Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. Alcoholism, Clinical and Experimental Research. 37: 8-15. PMID 22671690 DOI: 10.1111/j.1530-0277.2012.01846.x  0.44
2012 Alzghoul L, Bortolato M, Delis F, Thanos PK, Darling RD, Godar SC, Zhang J, Grant S, Wang GJ, Simpson KL, Chen K, Volkow ND, Lin RC, Shih JC. Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice. Neuropharmacology. 63: 1208-17. PMID 22971542 DOI: 10.1016/j.neuropharm.2012.08.003  0.44
2012 Bortolato M, Godar SC, Melis M, Soggiu A, Roncada P, Casu A, Flore G, Chen K, Frau R, Urbani A, Castelli MP, Devoto P, Shih JC. NMDARs mediate the role of monoamine oxidase A in pathological aggression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8574-82. PMID 22723698 DOI: 10.1523/JNEUROSCI.0225-12.2012  0.44
2012 Yardley MM, Wyatt L, Khoja S, Asatryan L, Ramaker MJ, Finn DA, Alkana RL, Huynh N, Louie SG, Petasis NA, Bortolato M, Davies DL. Ivermectin reduces alcohol intake and preference in mice. Neuropharmacology. 63: 190-201. PMID 22465817 DOI: 10.1016/j.neuropharm.2012.03.014  0.44
2012 Devoto P, Frau R, Bini V, Pillolla G, Saba P, Flore G, Corona M, Marrosu F, Bortolato M. Inhibition of 5α-reductase in the nucleus accumbens counters sensorimotor gating deficits induced by dopaminergic activation. Psychoneuroendocrinology. 37: 1630-45. PMID 22029952 DOI: 10.1016/j.psyneuen.2011.09.018  0.44
2011 Bortolato M, Shih JC. Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence. International Review of Neurobiology. 100: 13-42. PMID 21971001 DOI: 10.1016/B978-0-12-386467-3.00002-9  0.44
2011 Bortolato M, Chen K, Godar SC, Chen G, Wu W, Rebrin I, Farrell MR, Scott AL, Wellman CL, Shih JC. Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2674-88. PMID 21832987 DOI: 10.1038/npp.2011.157  0.44
2011 Paba S, Frau R, Godar SC, Devoto P, Marrosu F, Bortolato M. Steroid 5α-reductase as a novel therapeutic target for schizophrenia and other neuropsychiatric disorders. Current Pharmaceutical Design. 17: 151-67. PMID 21361868 DOI: 10.2174/138161211795049589  0.44
2011 Bortolato M, Devoto P, Roncada P, Frau R, Flore G, Saba P, Pistritto G, Soggiu A, Pisanu S, Zappala A, Ristaldi MS, Tattoli M, Cuomo V, Marrosu F, Barbaccia ML. Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments. Neuropharmacology. 60: 1301-8. PMID 21256141 DOI: 10.1016/j.neuropharm.2011.01.013  0.44
2011 Godar SC, Bortolato M, Frau R, Dousti M, Chen K, Shih JC. Maladaptive defensive behaviours in monoamine oxidase A-deficient mice. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 14: 1195-207. PMID 21156093 DOI: 10.1017/S1461145710001483  0.44
2010 Bortolato M, Godar SC. Animal models of virus-induced neurobehavioral sequelae: recent advances, methodological issues, and future prospects. Interdisciplinary Perspectives On Infectious Diseases. 2010: 380456. PMID 20490350 DOI: 10.1155/2010/380456  0.44
2010 Sciolino NR, Bortolato M, Eisenstein SA, Fu J, Oveisi F, Hohmann AG, Piomelli D. Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats. Neuroscience. 168: 371-86. PMID 20394803 DOI: 10.1016/j.neuroscience.2010.04.007  0.44
2010 Bortolato M, Frau R, Bini V, Luesu W, Loriga R, Collu M, Gessa GL, Ennas MG, Castelli MP. Methamphetamine neurotoxicity increases brain expression and alters behavioral functions of CB₁ cannabinoid receptors. Journal of Psychiatric Research. 44: 944-55. PMID 20378129 DOI: 10.1016/j.jpsychires.2010.03.002  0.44
2009 Bortolato M, Godar SC, Davarian S, Chen K, Shih JC. Behavioral disinhibition and reduced anxiety-like behaviors in monoamine oxidase B-deficient mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 2746-57. PMID 19710633 DOI: 10.1038/npp.2009.118  0.44
2009 Bortolato M, Frau R, Piras AP, Luesu W, Bini V, Diaz G, Gessa G, Ennas MG, Castelli MP. Methamphetamine induces long-term alterations in reactivity to environmental stimuli: correlation with dopaminergic and serotonergic toxicity. Neurotoxicity Research. 15: 232-45. PMID 19384596 DOI: 10.1007/s12640-009-9024-2  0.44
2008 Justinova Z, Mangieri RA, Bortolato M, Chefer SI, Mukhin AG, Clapper JR, King AR, Redhi GH, Yasar S, Piomelli D, Goldberg SR. Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates. Biological Psychiatry. 64: 930-7. PMID 18814866 DOI: 10.1016/j.biopsych.2008.08.008  0.44
2008 Bortolato M, Chen K, Shih JC. Monoamine oxidase inactivation: from pathophysiology to therapeutics. Advanced Drug Delivery Reviews. 60: 1527-33. PMID 18652859 DOI: 10.1016/j.addr.2008.06.002  0.44
2008 Koethe D, Bortolato M, Piomelli D, Leweke FM. Improvement of general symptoms in a chronic psychotic patient treated with finasteride: case report. Pharmacopsychiatry. 41: 115-6. PMID 18484553 DOI: 10.1055/s-2008-1058110  0.44
2008 Frau R, Orrù M, Puligheddu M, Gessa GL, Mereu G, Marrosu F, Bortolato M. Sleep deprivation disrupts prepulse inhibition of the startle reflex: reversal by antipsychotic drugs. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 11: 947-55. PMID 18477413 DOI: 10.1017/S1461145708008900  0.44
2008 Scott AL, Bortolato M, Chen K, Shih JC. Novel monoamine oxidase A knock out mice with human-like spontaneous mutation. Neuroreport. 19: 739-43. PMID 18418249 DOI: 10.1097/WNR.0b013e3282fd6e88  0.44
2008 Bortolato M, Frau R, Orrù M, Bourov Y, Marrosu F, Mereu G, Devoto P, Gessa GL. Antipsychotic-like properties of 5-alpha-reductase inhibitors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 3146-56. PMID 18354385 DOI: 10.1038/npp.2008.39  0.44
2007 Bortolato M, Frau R, Orrù M, Piras AP, Fà M, Tuveri A, Puligheddu M, Gessa GL, Castelli MP, Mereu G, Marrosu F. Activation of GABA(B) receptors reverses spontaneous gating deficits in juvenile DBA/2J mice. Psychopharmacology. 194: 361-9. PMID 17604981 DOI: 10.1007/s00213-007-0845-5  0.44
2007 Bortolato M, Mangieri RA, Fu J, Kim JH, Arguello O, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biological Psychiatry. 62: 1103-10. PMID 17511970 DOI: 10.1016/j.biopsych.2006.12.001  0.44
2007 Ballmaier M, Bortolato M, Rizzetti C, Zoli M, Gessa G, Heinz A, Spano P. Cannabinoid receptor antagonists counteract sensorimotor gating deficits in the phencyclidine model of psychosis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 2098-107. PMID 17299506 DOI: 10.1038/sj.npp.1301344  0.44
2007 Frau R, Orrù M, Fà M, Casti A, Manunta M, Fais N, Mereu G, Gessa G, Bortolato M. Effects of topiramate on the prepulse inhibition of the acoustic startle in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 320-31. PMID 16794573 DOI: 10.1038/sj.npp.1301115  0.44
2006 Bortolato M, Campolongo P, Mangieri RA, Scattoni ML, Frau R, Trezza V, La Rana G, Russo R, Calignano A, Gessa GL, Cuomo V, Piomelli D. Anxiolytic-like properties of the anandamide transport inhibitor AM404. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2652-9. PMID 16541083 DOI: 10.1038/sj.npp.1301061  0.44
2006 La Rana G, Russo R, Campolongo P, Bortolato M, Mangieri RA, Cuomo V, Iacono A, Raso GM, Meli R, Piomelli D, Calignano A. Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404 [N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide]. The Journal of Pharmacology and Experimental Therapeutics. 317: 1365-71. PMID 16510698 DOI: 10.1124/jpet.105.100792  0.44
2006 Bortolato M, Frau R, Orrù M, Casti A, Aru GN, Fà M, Manunta M, Usai A, Mereu G, Gessa GL. Prenatal exposure to a cannabinoid receptor agonist does not affect sensorimotor gating in rats. European Journal of Pharmacology. 531: 166-70. PMID 16423346 DOI: 10.1016/j.ejphar.2005.12.017  0.44
2005 Gobbi G, Bambico FR, Mangieri R, Bortolato M, Campolongo P, Solinas M, Cassano T, Morgese MG, Debonnel G, Duranti A, Tontini A, Tarzia G, Mor M, Trezza V, Goldberg SR, et al. Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proceedings of the National Academy of Sciences of the United States of America. 102: 18620-5. PMID 16352709 DOI: 10.1073/pnas.0509591102  0.44
2005 Bortolato M, Aru GN, Frau R, Orrù M, Fà M, Manunta M, Puddu M, Mereu G, Gessa GL. Kappa opioid receptor activation disrupts prepulse inhibition of the acoustic startle in rats. Biological Psychiatry. 57: 1550-8. PMID 15953492 DOI: 10.1016/j.biopsych.2005.02.030  0.44
2005 Bortolato M, Aru GN, Fà M, Frau R, Orrù M, Salis P, Casti A, Luckey GC, Mereu G, Gessa GL. Activation of D1, but not D2 receptors potentiates dizocilpine-mediated disruption of prepulse inhibition of the startle. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 561-74. PMID 15328529 DOI: 10.1038/sj.npp.1300547  0.44
2005 Bortolato M, Aru GN, Frau R, Orrù M, Luckey GC, Boi G, Gessa GL. The CB receptor agonist WIN 55,212-2 fails to elicit disruption of prepulse inhibition of the startle in Sprague-Dawley rats. Psychopharmacology. 177: 264-71. PMID 15290008 DOI: 10.1007/s00213-004-1941-4  0.44
2004 Bortolato M, Frau R, Aru GN, Orrù M, Gessa GL. Baclofen reverses the reduction in prepulse inhibition of the acoustic startle response induced by dizocilpine, but not by apomorphine. Psychopharmacology. 171: 322-30. PMID 13680072 DOI: 10.1007/s00213-003-1589-5  0.44
2001 Nava F, Carta G, Bortolato M, Gessa GL. gamma-Hydroxybutyric acid and baclofen decrease extracellular acetylcholine levels in the hippocampus via GABA(B) receptors. European Journal of Pharmacology. 430: 261-3. PMID 11711039 DOI: 10.1016/S0014-2999(01)01163-3  0.44
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