| Year |
Citation |
Score |
| 2023 |
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Abbracchio MP, Abraham G, Agoulnik A, Alexander W, et al. The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British Journal of Pharmacology. S23-S144. PMID 38123151 DOI: 10.1111/bph.16177 |
0.533 |
|
| 2023 |
Møller TC, Moo EV, Inoue A, Pedersen MF, Bräuner-Osborne H. Characterization of the real-time internalization of nine GPCRs reveals distinct dependence on arrestins and G proteins. Biochimica Et Biophysica Acta. Molecular Cell Research. 1871: 119584. PMID 37714305 DOI: 10.1016/j.bbamcr.2023.119584 |
0.335 |
|
| 2023 |
Deng Y, Moo EV, Inoue A, Bräuner-Osborne H. Endocytic proteins mediating GPR15 receptor internalization provide insight into the underlying mechanisms. Febs Letters. PMID 37051832 DOI: 10.1002/1873-3468.14622 |
0.304 |
|
| 2022 |
van Senten JR, Møller TC, Von Moo E, Seiersen SD, Bräuner-Osborne H. Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C isozymes are involved in mGlu receptor internalization. The Journal of Biological Chemistry. 102466. PMID 36087841 DOI: 10.1016/j.jbc.2022.102466 |
0.305 |
|
| 2021 |
Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsøe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Bräuner-Osborne H, Gloriam DE, Hua T, Liu ZJ. Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Research. PMID 34916631 DOI: 10.1038/s41422-021-00591-w |
0.306 |
|
| 2021 |
Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Abbracchio MP, Alexander W, et al. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. British Journal of Pharmacology. 178: S27-S156. PMID 34529832 DOI: 10.1111/bph.15538 |
0.533 |
|
| 2021 |
Gao Y, Robertson MJ, Rahman SN, Seven AB, Zhang C, Meyerowitz JG, Panova O, Hannan FM, Thakker RV, Bräuner-Osborne H, Mathiesen JM, Skiniotis G. Asymmetric activation of the calcium-sensing receptor homodimer. Nature. PMID 34194040 DOI: 10.1038/s41586-021-03691-0 |
0.315 |
|
| 2021 |
Arsova A, Møller TC, Hellyer SD, Vedel L, Foster SR, Hansen JL, Bräuner-Osborne H, Gregory KJ. Positive allosteric modulators of metabotropic glutamate receptor 5 as tool compounds to study signaling bias. Molecular Pharmacology. PMID 33602724 DOI: 10.1124/molpharm.120.000185 |
0.365 |
|
| 2020 |
Leach K, Hannan FM, Josephs TM, Keller AN, Møller TC, Ward DT, Kallay E, Mason RS, Thakker RV, Riccardi D, Conigrave AD, Bräuner-Osborne H. International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function. Pharmacological Reviews. 72: 558-604. PMID 32467152 DOI: 10.1124/pr.119.018531 |
0.366 |
|
| 2020 |
Arsova A, Møller TC, Vedel L, Hansen JL, Foster SR, Gregory KJ, Bräuner-Osborne H. Detailed in vitro pharmacological characterization of clinically tested negative allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). Molecular Pharmacology. PMID 32358164 DOI: 10.1124/mol.119.119032 |
0.359 |
|
| 2020 |
Jensen AA, Halberstadt AL, Märcher-Rørsted E, Odland AU, Chatha M, Speth N, Liebscher G, Hansen M, Bräuner-Osborne H, Palner M, Andreasen JT, Kristensen JL. The selective 5-HT receptor agonist 25CN-NBOH: Structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [H]25CN-NBOH. Biochemical Pharmacology. 177: 113979. PMID 32298690 DOI: 10.1016/J.Bcp.2020.113979 |
0.318 |
|
| 2020 |
Jørgensen CV, Bräuner-Osborne H. Pharmacology and physiological function of the orphan GPRC6A receptor. Basic & Clinical Pharmacology & Toxicology. 126: 77-87. PMID 32056382 DOI: 10.1111/bcpt.13397 |
0.391 |
|
| 2020 |
Gabe MBN, van der Velden WJC, Gadgaard S, Smit FX, Hartmann B, Bräuner-Osborne H, Rosenkilde MM. Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system. Basic & Clinical Pharmacology & Toxicology. 126: 122-132. PMID 31299132 DOI: 10.1111/bcpt.13289 |
0.302 |
|
| 2020 |
Vedel L, Nøhr AC, Gloriam DE, Bräuner-Osborne H. Pharmacology and function of the orphan GPR139 G protein-coupled receptor. Basic & Clinical Pharmacology & Toxicology. 126: 35-46. PMID 31132229 DOI: 10.1111/bcpt.13263 |
0.368 |
|
| 2019 |
Mos I, Jacobsen SE, Foster S, Brauner-Osborne H. Calcium-sensing receptor internalization is β-arrestin-dependent and modulated by allosteric ligands. Molecular Pharmacology. PMID 31399503 DOI: 10.1124/mol.119.116772 |
0.307 |
|
| 2019 |
Pedersen MF, Wróbel TM, Märcher-Rørsted E, Pedersen DS, Møller TC, Gabriele F, Pedersen H, Matosiuk D, Foster SR, Bouvier M, Bräuner-Osborne H. Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics. Neuropharmacology. 107718. PMID 31351108 DOI: 10.1016/J.Neuropharm.2019.107718 |
0.32 |
|
| 2019 |
Bräuner-Osborne H, Rosenkilde MM, Gether U, Gloriam DE. G protein-coupled receptor pharmacology - the next generation. Basic & Clinical Pharmacology & Toxicology. PMID 31301209 DOI: 10.1111/Bcpt.13291 |
0.344 |
|
| 2017 |
Frandsen IO, Boesgaard MW, Fidom K, Hauser AS, Isberg V, Bräuner-Osborne H, Wellendorph P, Gloriam DE. Identification of Histamine H Receptor Ligands Using a New Crystal Structure Fragment-based Method. Scientific Reports. 7: 4829. PMID 28684785 DOI: 10.1038/S41598-017-05058-W |
0.344 |
|
| 2017 |
Jessen M, Frederiksen K, Yi F, Clausen RP, Hansen KB, Brauner-Osborne H, Kilburn P, Damholt A. Identification of AICP as a GluN2C-selective NMDA receptor superagonist at the GluN1 glycine site. Molecular Pharmacology. PMID 28588066 DOI: 10.1124/Mol.117.108944 |
0.359 |
|
| 2017 |
Jacobsen SE, Gether U, Bräuner-Osborne H. Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer. Scientific Reports. 7: 46355. PMID 28417952 DOI: 10.1038/Srep46355 |
0.357 |
|
| 2017 |
Jensen AA, McCorvy JD, Petersen SL, Bundgaard C, Liebscher G, Kenakin TP, Brauner-Osborne H, Kehler J, Kristensen JL. Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist. The Journal of Pharmacology and Experimental Therapeutics. PMID 28360333 DOI: 10.1124/jpet.117.239905 |
0.361 |
|
| 2017 |
Jacobsen SE, Ammendrup-Johnsen I, Jansen AM, Gether U, Madsen KL, Bräuner-Osborne H. The GPRC6A Receptor displays Constitutive Internalization and Sorting to the Slow Recycling Pathway. The Journal of Biological Chemistry. PMID 28280242 DOI: 10.1074/Jbc.M116.762385 |
0.358 |
|
| 2016 |
Jørgensen S, Have CT, Underwood CR, Johansen LD, Wellendorph P, Gjesing AP, Jørgensen CV, Quan S, Rui G, Inoue A, Linneberg A, Grarup N, Jun W, Pedersen O, Hansen T, et al. Genetic Variations in the Human GPRC6A Receptor Control Cell Surface Expression and Function. The Journal of Biological Chemistry. PMID 27986810 DOI: 10.1074/Jbc.M116.756577 |
0.313 |
|
| 2016 |
Shehata MA, Nøhr AC, Lissa D, Bisig C, Isberg V, Andersen KB, Harpsøe K, Björkling F, Bräuner-Osborne H, Gloriam DE. Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139. Scientific Reports. 6: 36681. PMID 27830715 DOI: 10.1038/srep36681 |
0.334 |
|
| 2015 |
Johansson H, Boesgaard MW, Nørskov-Lauritsen L, Larsen I, Kuhne S, Gloriam DE, Bräuner-Osborne H, Sejer Pedersen D. Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold. Journal of Medicinal Chemistry. 58: 8938-51. PMID 26516782 DOI: 10.1021/acs.jmedchem.5b01254 |
0.402 |
|
| 2015 |
Harpsøe K, Isberg V, Tehan BG, Weiss D, Arsova A, Marshall FH, Bräuner-Osborne H, Gloriam DE. Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants. Scientific Reports. 5: 13869. PMID 26359761 DOI: 10.1038/Srep13869 |
0.373 |
|
| 2015 |
Nørskov-Lauritsen L, Bräuner-Osborne H. Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors. European Journal of Pharmacology. 763: 233-40. PMID 25981296 DOI: 10.1016/j.ejphar.2015.05.015 |
0.384 |
|
| 2015 |
Hansen M, Jacobsen SE, Plunkett S, Liebscher GE, McCorvy JD, Bräuner-Osborne H, Kristensen JL. Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists. Bioorganic & Medicinal Chemistry. 23: 3933-7. PMID 25583099 DOI: 10.1016/j.bmc.2014.12.011 |
0.307 |
|
| 2014 |
Hansen M, Phonekeo K, Paine JS, Leth-Petersen S, Begtrup M, Bräuner-Osborne H, Kristensen JL. Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. Acs Chemical Neuroscience. 5: 243-9. PMID 24397362 DOI: 10.1021/cn400216u |
0.344 |
|
| 2014 |
Roed SN, Wismann P, Underwood CR, Kulahin N, Iversen H, Cappelen KA, Schäffer L, Lehtonen J, Hecksher-Soerensen J, Secher A, Mathiesen JM, Bräuner-Osborne H, Whistler JL, Knudsen SM, Waldhoer M. Real-time trafficking and signaling of the glucagon-like peptide-1 receptor. Molecular and Cellular Endocrinology. 382: 938-49. PMID 24275181 DOI: 10.1016/J.Mce.2013.11.010 |
0.315 |
|
| 2014 |
Smajilovic S, Wellendorph P, Bräuner-Osborne H. Promiscuous seven transmembrane receptors sensing L-α-amino acids. Current Pharmaceutical Design. 20: 2693-702. PMID 23886393 DOI: 10.2174/13816128113199990576 |
0.317 |
|
| 2013 |
Kvist T, Steffensen TB, Greenwood JR, Mehrzad Tabrizi F, Hansen KB, Gajhede M, Pickering DS, Traynelis SF, Kastrup JS, Bräuner-Osborne H. Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. The Journal of Biological Chemistry. 288: 33124-35. PMID 24072709 DOI: 10.1074/Jbc.M113.480210 |
0.327 |
|
| 2013 |
Jacobsen SE, Nørskov-Lauritsen L, Thomsen AR, Smajilovic S, Wellendorph P, Larsson NH, Lehmann A, Bhatia VK, Bräuner-Osborne H. Delineation of the GPRC6A receptor signaling pathways using a mammalian cell line stably expressing the receptor. The Journal of Pharmacology and Experimental Therapeutics. 347: 298-309. PMID 24008333 DOI: 10.1124/Jpet.113.206276 |
0.376 |
|
| 2013 |
Attia MI, Herdeis C, Bräuner-Osborne H. GABA(B)-agonistic activity of certain baclofen homologues. Molecules (Basel, Switzerland). 18: 10266-84. PMID 23973998 DOI: 10.3390/molecules180910266 |
0.366 |
|
| 2013 |
Kvist T, Greenwood JR, Hansen KB, Traynelis SF, Bräuner-Osborne H. Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors. Neuropharmacology. 75: 324-36. PMID 23973313 DOI: 10.1016/J.Neuropharm.2013.08.003 |
0.384 |
|
| 2012 |
Absalom N, Eghorn LF, Villumsen IS, Karim N, Bay T, Olsen JV, Knudsen GM, Bräuner-Osborne H, Frølund B, Clausen RP, Chebib M, Wellendorph P. α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). Proceedings of the National Academy of Sciences of the United States of America. 109: 13404-9. PMID 22753476 DOI: 10.1073/Pnas.1204376109 |
0.414 |
|
| 2012 |
Hedegaard M, Hansen KB, Andersen KT, Bräuner-Osborne H, Traynelis SF. Molecular pharmacology of human NMDA receptors. Neurochemistry International. 61: 601-9. PMID 22197913 DOI: 10.1016/J.Neuint.2011.11.016 |
0.345 |
|
| 2011 |
Gloriam DE, Wellendorph P, Johansen LD, Thomsen AR, Phonekeo K, Pedersen DS, Bräuner-Osborne H. Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor. Chemistry & Biology. 18: 1489-98. PMID 22118683 DOI: 10.1016/J.Chembiol.2011.09.012 |
0.324 |
|
| 2010 |
Wellendorph P, Johansen LD, Bräuner-Osborne H. The emerging role of promiscuous 7TM receptors as chemosensors for food intake. Vitamins and Hormones. 84: 151-84. PMID 21094899 DOI: 10.1016/B978-0-12-381517-0.00005-9 |
0.394 |
|
| 2010 |
Mosley CA, Acker TM, Hansen KB, Mullasseril P, Andersen KT, Le P, Vellano KM, Bräuner-Osborne H, Liotta DC, Traynelis SF. Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. Journal of Medicinal Chemistry. 53: 5476-90. PMID 20684595 DOI: 10.1021/Jm100027P |
0.333 |
|
| 2010 |
Conti P, Pinto A, Tamborini L, Madsen U, Nielsen B, Bräuner-Osborne H, Hansen KB, Landucci E, Pellegrini-Giampietro DE, De Sarro G, Donato Di Paola E, De Micheli C. Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists: design, synthesis, and pharmacological characterization. Chemmedchem. 5: 1465-75. PMID 20665761 DOI: 10.1002/Cmdc.201000184 |
0.344 |
|
| 2010 |
Hansen KB, Mullasseril P, Dawit S, Kurtkaya NL, Yuan H, Vance KM, Orr AG, Kvist T, Ogden KK, Le P, Vellano KM, Lewis I, Kurtkaya S, Du Y, Qui M, et al. Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists. The Journal of Pharmacology and Experimental Therapeutics. 333: 650-62. PMID 20197375 DOI: 10.1124/Jpet.110.166256 |
0.359 |
|
| 2010 |
Jensen AA, Bräuner-Osborne H. Allosteric modulation of the calcium-sensing receptor. Current Neuropharmacology. 5: 180-6. PMID 19305800 DOI: 10.2174/157015907781695982 |
0.344 |
|
| 2009 |
Lehmann A, Antonsson M, Holmberg AA, Blackshaw LA, Brändén L, Bräuner-Osborne H, Christiansen B, Dent J, Elebring T, Jacobson BM, Jensen J, Mattsson JP, Nilsson K, Oja SS, Page AJ, et al. (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABA B receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action Journal of Pharmacology and Experimental Therapeutics. 331: 504-512. PMID 19648470 DOI: 10.1124/jpet.109.153593 |
0.411 |
|
| 2009 |
Wellendorph P, Høg S, Skonberg C, Bräuner-Osborne H. Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific gamma-hydroxybutyric acid sites in rat brain. Fundamental & Clinical Pharmacology. 23: 207-13. PMID 19645815 DOI: 10.1111/J.1472-8206.2008.00664.X |
0.325 |
|
| 2009 |
Wellendorph P, Johansen LD, Bräuner-Osborne H. Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Molecular Pharmacology. 76: 453-65. PMID 19487246 DOI: 10.1124/Mol.109.055244 |
0.401 |
|
| 2009 |
Kvist T, Christiansen B, Jensen AA, Bräuner-Osborne H. The four human gamma-aminobutyric acid (GABA) transporters: pharmacological characterization and validation of a highly efficient screening assay. Combinatorial Chemistry & High Throughput Screening. 12: 241-9. PMID 19275529 DOI: 10.2174/138620709787581684 |
0.323 |
|
| 2009 |
Guetg N, Seddik R, Vigot R, Turecek R, Gassmann M, Vogt KE, Bräuner-Osborne H, Shigemoto R, Kretz O, Frotscher M, Kulik A, Bettler B. The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1414-23. PMID 19193888 DOI: 10.1523/Jneurosci.3697-08.2009 |
0.526 |
|
| 2009 |
Wellendorph P, Johansen LD, Jensen AA, Casanova E, Gassmann M, Deprez P, Clément-Lacroix P, Bettler B, Bräuner-Osborne H. No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. Journal of Molecular Endocrinology. 42: 215-23. PMID 19103720 DOI: 10.1677/Jme-08-0149 |
0.467 |
|
| 2009 |
Jensen AA, Davies PA, Bräuner-Osborne H, Krzywkowski K. 3B but which 3B and that's just one of the questions: the heterogeneity of human 5-HT3 receptors. Trends in Pharmacological Sciences. 29: 437-44. PMID 18597859 DOI: 10.1016/j.tips.2008.06.001 |
0.301 |
|
| 2008 |
Høg S, Wellendorph P, Nielsen B, Frydenvang K, Dahl IF, Bräuner-Osborne H, Brehm L, Frølund B, Clausen RP. Novel high-affinity and selective biaromatic 4-substituted γ-hydroxybutyric acid (GHB) analogues as GHB ligands: Design, synthesis, and binding studies Journal of Medicinal Chemistry. 51: 8088-8095. PMID 19053823 DOI: 10.1021/Jm801112U |
0.39 |
|
| 2008 |
Krzywkowski K, Davies PA, Irving AJ, Bräuner-Osborne H, Jensen AA. Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling. Pharmacogenetics and Genomics. 18: 1027-40. PMID 19008750 DOI: 10.1097/FPC.0b013e328310f950 |
0.323 |
|
| 2008 |
Clausen RP, Christensen C, Hansen KB, Greenwood JR, Jørgensen L, Micale N, Madsen JC, Nielsen B, Egebjerg J, Bräuner-Osborne H, Traynelis SF, Kristensen JL. N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands. Journal of Medicinal Chemistry. 51: 4179-87. PMID 18578474 DOI: 10.1021/Jm800025E |
0.305 |
|
| 2008 |
Hansen KB, Bräuner-Osborne H, Egebjerg J. Pharmacological characterization of ligands at recombinant NMDA receptor subtypes by electrophysiological recordings and intracellular calcium measurements. Combinatorial Chemistry & High Throughput Screening. 11: 304-15. PMID 18473740 DOI: 10.2174/138620708784246040 |
0.336 |
|
| 2008 |
Pinto A, Conti P, De Amici M, Tamborini L, Madsen U, Nielsen B, Christesen T, Bräuner-Osborne H, De Micheli C. Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid. Journal of Medicinal Chemistry. 51: 2311-5. PMID 18338843 DOI: 10.1021/jm701394a |
0.333 |
|
| 2008 |
Krzywkowski K, Davies PA, Feinberg-Zadek PL, Bräuner-Osborne H, Jensen AA. High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor. Proceedings of the National Academy of Sciences of the United States of America. 105: 722-7. PMID 18184810 DOI: 10.1073/pnas.0708454105 |
0.352 |
|
| 2007 |
Jensen AA, Christesen T, Bølcho U, Greenwood JR, Postorino G, Vogensen SB, Johansen TN, Egebjerg J, Bräuner-Osborne H, Clausen RP. Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA. Journal of Medicinal Chemistry. 50: 4177-85. PMID 17672447 DOI: 10.1021/jm070532r |
0.334 |
|
| 2007 |
Jørgensen CG, Bräuner-Osborne H, Nielsen B, Kehler J, Clausen RP, Krogsgaard-Larsen P, Madsen U. Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors. Bioorganic & Medicinal Chemistry. 15: 3524-38. PMID 17376693 DOI: 10.1016/j.bmc.2007.02.047 |
0.317 |
|
| 2007 |
Jørgensen CG, Clausen RP, Hansen KB, Bräuner-Osborne H, Nielsen B, Metzler B, Metzler BB, Kehler J, Krogsgaard-Larsen P, Madsen U. Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid. Organic & Biomolecular Chemistry. 5: 463-71. PMID 17340770 DOI: 10.1039/B615162K |
0.322 |
|
| 2007 |
Bräuner-Osborne H, Wellendorph P, Jensen AA. Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Current Drug Targets. 8: 169-84. PMID 17266540 DOI: 10.2174/138945007779315614 |
0.448 |
|
| 2006 |
Vigot R, Barbieri S, Bräuner-Osborne H, Turecek R, Shigemoto R, Zhang YP, Luján R, Jacobson LH, Biermann B, Fritschy JM, Vacher CM, Müller M, Sansig G, Guetg N, Cryan JF, et al. Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron. 50: 589-601. PMID 16701209 DOI: 10.1016/J.Neuron.2006.04.014 |
0.516 |
|
| 2006 |
Christiansen B, Wellendorph P, Bräuner-Osborne H. Known regulators of nitric oxide synthase and arginase are agonists at the human G-protein-coupled receptor GPRC6A. British Journal of Pharmacology. 147: 855-63. PMID 16491104 DOI: 10.1038/Sj.Bjp.0706682 |
0.326 |
|
| 2006 |
Strange M, Bräuner-Osborne H, Jensen AA. Functional characterisation of homomeric ionotropic glutamate receptors GluR1-GluR6 in a fluorescence-based high throughput screening assay. Combinatorial Chemistry & High Throughput Screening. 9: 147-58. PMID 16475972 DOI: 10.2174/138620706775541918 |
0.307 |
|
| 2005 |
Bräuner-Osborne H, Bunch L, Chopin N, Couty F, Evano G, Jensen AA, Kusk M, Nielsen B, Rabasso N. Azetidinic amino acids: stereocontrolled synthesis and pharmacological characterization as ligands for glutamate receptors and transporters. Organic & Biomolecular Chemistry. 3: 3926-36. PMID 16240010 DOI: 10.1039/B509514J |
0.313 |
|
| 2005 |
Conti P, De Amici M, Grazioso G, Roda G, Pinto A, Hansen KB, Nielsen B, Madsen U, Bräuner-Osborne H, Egebjerg J, Vestri V, Pellegrini-Giampietro DE, Sibille P, Acher FC, De Micheli C. Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids. Journal of Medicinal Chemistry. 48: 6315-25. PMID 16190758 DOI: 10.1021/Jm0504499 |
0.332 |
|
| 2005 |
Hansen KB, Clausen RP, Bjerrum EJ, Bechmann C, Greenwood JR, Christensen C, Kristensen JL, Egebjerg J, Bräuner-Osborne H. Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis. Molecular Pharmacology. 68: 1510-23. PMID 16131614 DOI: 10.1124/Mol.105.014795 |
0.303 |
|
| 2005 |
Frølund B, Greenwood JR, Holm MM, Egebjerg J, Madsen U, Nielsen B, Bräuner-Osborne H, Stensbøl TB, Krogsgaard-Larsen P. Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology. Bioorganic & Medicinal Chemistry. 13: 5391-8. PMID 16043357 DOI: 10.1016/j.bmc.2005.06.024 |
0.31 |
|
| 2005 |
Wellendorph P, Høg S, Greenwood JR, de Lichtenberg A, Nielsen B, Frølund B, Brehm L, Clausen RP, Bräuner-Osborne H. Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain. The Journal of Pharmacology and Experimental Therapeutics. 315: 346-51. PMID 16014570 DOI: 10.1124/Jpet.105.090472 |
0.388 |
|
| 2005 |
Madsen U, Pickering DS, Nielsen B, Bräuner-Osborne H. 4-Alkylated homoibotenic acid (HIBO) analogues: versatile pharmacological agents with diverse selectivity profiles towards metabotropic and ionotropic glutamate receptor subtypes. Neuropharmacology. 114-9. PMID 15996690 DOI: 10.1016/j.neuropharm.2005.05.007 |
0.308 |
|
| 2005 |
Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H. Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Molecular Pharmacology. 67: 589-97. PMID 15576628 DOI: 10.1124/Mol.104.007559 |
0.381 |
|
| 2004 |
Clausen RP, Hansen KB, Calà P, Nielsen B, Greenwood JR, Begtrup M, Egebjerg J, Bräuner-Osborne H. The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid. European Journal of Pharmacology. 499: 35-44. PMID 15363949 DOI: 10.1016/J.Ejphar.2004.07.049 |
0.334 |
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| 2004 |
Wellendorph P, Bräuner-Osborne H. Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. Gene. 335: 37-46. PMID 15194188 DOI: 10.1016/J.Gene.2004.03.003 |
0.306 |
|
| 2003 |
Kaupmann K, Cryan JF, Wellendorph P, Mombereau C, Sansig G, Klebs K, Schmutz M, Froestl W, van der Putten H, Mosbacher J, Bräuner-Osborne H, Waldmeier P, Bettler B. Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice. The European Journal of Neuroscience. 18: 2722-30. PMID 14656321 DOI: 10.1111/J.1460-9568.2003.03013.X |
0.548 |
|
| 2003 |
Valgeirsson J, Christensen JK, Kristensen AS, Pickering DS, Nielsen B, Fischer CH, Bräuner-Osborne H, Nielsen EØ, Krogsgaard-Larsen P, Madsen U. Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues. Bioorganic & Medicinal Chemistry. 11: 4341-9. PMID 13129570 DOI: 10.1016/S0968-0896(03)00485-1 |
0.37 |
|
| 2003 |
Bjerrum EJ, Kristensen AS, Pickering DS, Greenwood JR, Nielsen B, Liljefors T, Schousboe A, Bräuner-Osborne H, Madsen U. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). Journal of Medicinal Chemistry. 46: 2246-9. PMID 12747796 DOI: 10.1021/Jm020588F |
0.34 |
|
| 2003 |
Runge S, Gram C, Brauner-Osborne H, Madsen K, Knudsen LB, Wulff BS. Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus. The Journal of Biological Chemistry. 278: 28005-10. PMID 12724331 DOI: 10.1074/jbc.M301085200 |
0.351 |
|
| 2003 |
Brehm L, Greenwood JR, Hansen KB, Nielsen B, Egebjerg J, Stensbøl TB, Bräuner-Osborne H, Sløk FA, Kronborg TT, Krogsgaard-Larsen P. (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology. Journal of Medicinal Chemistry. 46: 1350-8. PMID 12672235 DOI: 10.1021/Jm0204441 |
0.328 |
|
| 2002 |
Jensen AA, Hansen JL, Sheikh SP, Bräuner-Osborne H. Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET). European Journal of Biochemistry / Febs. 269: 5076-87. PMID 12383267 DOI: 10.1046/J.1432-1033.2002.03218.X |
0.36 |
|
| 2002 |
Jensen AA, Mosbacher J, Elg S, Lingenhoehl K, Lohmann T, Johansen TN, Abrahamsen B, Mattsson JP, Lehmann A, Bettler B, Bräuner-Osborne H. The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors. Molecular Pharmacology. 61: 1377-84. PMID 12021399 DOI: 10.1124/Mol.61.6.1377 |
0.532 |
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