| Year |
Citation |
Score |
| 2024 |
Tai YT, Podar K, Catley L, Tseng YH, Akiyama M, Shringarpure R, Burger R, Hideshima T, Chauhan D, Mitsiades N, Richardson P, Munshi NC, Kahn CR, Mitsiades C, Anderson KC. Retraction: Insulin-like Growth Factor-1 Induces Adhesion and Migration in Human Multiple Myeloma Cells via Activation of β1-Integrin and Phosphatidylinositol 3'-Kinase/AKT Signaling. Cancer Research. 84: 938. PMID 38486484 DOI: 10.1158/0008-5472.CAN-24-0519 |
0.324 |
|
| 2023 |
Haider N, Kahn CR. Interactions between insulin resistance, epigenetics, and donor sex in gene expression regulation of iPSC-derived myoblasts. The Journal of Clinical Investigation. PMID 38032738 DOI: 10.1172/JCI172333 |
0.439 |
|
| 2023 |
Allu PKR, Cardamone MD, Gomes AS, Dall'agnese A, Cederquist C, Pan H, Dreyfuss JM, Enerbäck S, Kahn CR. FoxK1 associated gene regulatory network in hepatic insulin action and its relationship to FoxO1 and insulin receptor mediated transcriptional regulation. Molecular Metabolism. 78: 101825. PMID 37852413 DOI: 10.1016/j.molmet.2023.101825 |
0.452 |
|
| 2023 |
Lee WH, Najjar SM, Kahn CR, Hinds TD. Hepatic insulin receptor: new views on the mechanisms of liver disease. Metabolism: Clinical and Experimental. 145: 155607. PMID 37271372 DOI: 10.1016/j.metabol.2023.155607 |
0.426 |
|
| 2023 |
Chen W, Huang Q, Lazdon EK, Gomes A, Wong M, Stephens E, Royal TG, Frenkel D, Cai W, Kahn CR. Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model. Proceedings of the National Academy of Sciences of the United States of America. 120: e2220684120. PMID 37186836 DOI: 10.1073/pnas.2220684120 |
0.746 |
|
| 2023 |
Lagarrigue S, Lopez-Mejia IC, Denechaud PD, Escoté X, Castillo-Armengol J, Jimenez V, Chavey C, Giralt A, Lai Q, Zhang L, Martinez-Carreres L, Delacuisine B, Annicotte JS, Blanchet E, Huré S, ... ... Kahn CR, et al. CDK4 is an essential insulin effector in adipocytes. The Journal of Clinical Investigation. 133. PMID 36919703 DOI: 10.1172/JCI170315 |
0.472 |
|
| 2023 |
Nagao H, Jayavelu AK, Cai W, Pan H, Dreyfuss JM, Batista TM, Brandão BB, Mann M, Kahn CR. Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis. Nature Communications. 14: 57. PMID 36599833 DOI: 10.1038/s41467-022-35693-5 |
0.598 |
|
| 2022 |
Nagao H, Cai W, Brasil Brandão B, Wewer Albrechtsen NJ, Steger M, Gattu AK, Pan H, Dreyfuss JM, Wunderlich FT, Mann M, Kahn CR. Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling. The Journal of Clinical Investigation. PMID 36548088 DOI: 10.1172/JCI161472 |
0.664 |
|
| 2022 |
Sakaguchi M, Okagawa S, Okubo Y, Otsuka Y, Fukuda K, Igata M, Kondo T, Sato Y, Yoshizawa T, Fukuda T, Yamagata K, Cai W, Tseng YH, Sakaguchi N, Kahn CR, et al. Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling. Nature Communications. 13: 6092. PMID 36241662 DOI: 10.1038/s41467-022-33842-4 |
0.677 |
|
| 2022 |
Sasako T, Umehara T, Soeda K, Kaneko K, Suzuki M, Kobayashi N, Okazaki Y, Tamura-Nakano M, Chiba T, Accili D, Kahn CR, Noda T, Asahara H, Yamauchi T, Kadowaki T, et al. Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice. Nature Communications. 13: 5655. PMID 36198696 DOI: 10.1038/s41467-022-33008-2 |
0.418 |
|
| 2022 |
Lagarrigue S, Lopez-Mejia IC, Denechaud PD, Escoté X, Castillo-Armengol J, Jimenez V, Chavey C, Giralt A, Lai Q, Zhang L, Martinez-Carreres L, Delacuisine B, Annicotte JS, Blanchet E, Huré S, ... ... Kahn CR, et al. CDK4 is an essential insulin effector in adipocytes. The Journal of Clinical Investigation. 132. PMID 35775487 DOI: 10.1172/JCI162359 |
0.472 |
|
| 2022 |
Chen W, Cai W, Hoover B, Kahn CR. Insulin action in the brain: cell types, circuits, and diseases. Trends in Neurosciences. PMID 35361499 DOI: 10.1016/j.tins.2022.03.001 |
0.733 |
|
| 2022 |
Batista TM, Haider N, Kahn CR. Correction to: Defining the underlying defect in insulin action in type 2 diabetes. Diabetologia. PMID 35320373 DOI: 10.1007/s00125-022-05684-8 |
0.335 |
|
| 2022 |
Bhardwaj G, Penniman CM, Klaus K, Weatherford ET, Pan H, Dreyfuss JM, Nair KS, Kahn CR, O'Neill BT. Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors. Frontiers in Physiology. 12: 779121. PMID 35185597 DOI: 10.3389/fphys.2021.779121 |
0.324 |
|
| 2021 |
Haider N, Lebastchi J, Jayavelu AK, Batista TM, Pan H, Dreyfuss JM, Carcamo-Orive I, Knowles JW, Mann M, Kahn CR. Signaling defects associated with insulin resistance in non-diabetic and diabetic individuals and modification by sex. The Journal of Clinical Investigation. PMID 34506305 DOI: 10.1172/JCI151818 |
0.385 |
|
| 2021 |
Kahn CR. "100 Years of progress in understanding insulin, its mechanism of action, and its roles in disease and diabetes therapy". Molecular Metabolism. 101318. PMID 34478731 DOI: 10.1016/j.molmet.2021.101318 |
0.304 |
|
| 2021 |
Homan EP, Brasil Brandao B, Softic S, El Ouaamari A, O'Neill BT, Kulkarni RN, Kim JK, Kahn CR. Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue. The Journal of Clinical Investigation. PMID 34428182 DOI: 10.1172/JCI143328 |
0.506 |
|
| 2021 |
Zhang F, Altindis E, Kahn CR, DiMarchi RD, Gelfanov V. A Viral Insulin-Like Peptide is a Natural Competitive Antagonist of the Human IGF-1 Receptor. Molecular Metabolism. 101316. PMID 34400347 DOI: 10.1016/j.molmet.2021.101316 |
0.355 |
|
| 2021 |
Mori Y, Gonzalez Medina M, Liu Z, Guo J, Dingwell LS, Chiang S, Kahn CR, Husain M, Giacca A. Roles of vascular endothelial and smooth muscle cells in the vasculoprotective effect of insulin in a mouse model of restenosis. Diabetes & Vascular Disease Research. 18: 14791641211027324. PMID 34190643 DOI: 10.1177/14791641211027324 |
0.323 |
|
| 2021 |
Cai W, Zhang X, Batista TM, García-Martín R, Softic S, Wang G, Ramirez AK, Konishi M, O'Neill BT, Kim JH, Kim JK, Kahn CR. Peripheral Insulin Regulates a Broad Network of Gene Expression in the Hypothalamus, Hippocampus and Nucleus Accumbens. Diabetes. PMID 34031123 DOI: 10.2337/db20-1119 |
0.649 |
|
| 2021 |
Nagao H, Cai W, Wewer Albrechtsen NJ, Steger M, Batista TM, Pan H, Dreyfuss JM, Mann M, Kahn CR. Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33879610 DOI: 10.1073/pnas.2019474118 |
0.642 |
|
| 2021 |
Batista TM, Haider N, Kahn CR. Defining the underlying defect in insulin action in type 2 diabetes. Diabetologia. 64: 994-1006. PMID 33730188 DOI: 10.1007/s00125-021-05415-5 |
0.501 |
|
| 2021 |
Flier JS, Kahn CR. Insulin: A Pacesetter for the Shape of Modern Biomedical Science and the Nobel Prize. Molecular Metabolism. 101194. PMID 33610859 DOI: 10.1016/j.molmet.2021.101194 |
0.379 |
|
| 2020 |
Chrudinová M, Moreau F, Noh HL, Páníková T, Žáková L, Friedline RH, Valenzuela FA, Kim JK, Jiráček J, Kahn CR, Altindis E. Characterization of Viral Insulins Reveals White Adipose Tissue Specific Effects in Mice. Molecular Metabolism. 101121. PMID 33220491 DOI: 10.1016/j.molmet.2020.101121 |
0.437 |
|
| 2020 |
Brandão BB, Madsen S, Rabiee A, Oliverio M, Ruiz GP, Ferrucci DL, Branquinho JL, Razolli D, Pinto S, Nielsen TS, Festuccia WT, Martins AS, Guerra BA, Knittel TL, Søgaard D, ... ... Kahn CR, et al. Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise. Proceedings of the National Academy of Sciences of the United States of America. PMID 32900951 DOI: 10.1073/Pnas.2011243117 |
0.314 |
|
| 2020 |
Batista TM, Jayavelu AK, Wewer Albrechtsen NJ, Iovino S, Lebastchi J, Pan H, Dreyfuss JM, Krook A, Zierath JR, Mann M, Kahn CR. A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes. Cell Metabolism. PMID 32888406 DOI: 10.1016/J.Cmet.2020.08.007 |
0.537 |
|
| 2020 |
Wang G, Yu Y, Cai W, Batista TM, Suk S, Noh HL, Hirshman M, Nigro P, Li ME, Softic S, Goodyear L, Kim JK, Kahn CR. Muscle Specific Insulin Receptor Overexpression Protects Mice from Diet-Induced Glucose Intolerance but Leads to Post-Receptor Insulin Resistance. Diabetes. PMID 32868340 DOI: 10.2337/Db20-0439 |
0.719 |
|
| 2020 |
Winnay JN, Solheim MH, Sakaguchi M, Njølstad PR, Kahn CR. Inhibition of the PI 3-kinase pathway disrupts the unfolded protein response and reduces sensitivity to ER stress-dependent apoptosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32744782 DOI: 10.1096/Fj.202000892R |
0.367 |
|
| 2020 |
Nilsen MS, Jersin RÅ, Ulvik A, Madsen A, McCann A, Svensson PA, Svensson ME, Nedrebø BG, Gudbrandsen OA, Tell GS, Kahn CR, Ueland PM, Mellgren G, Dankel SN. 3-Hydroxyisobutyrate, a Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism. Diabetes. PMID 32586980 DOI: 10.2337/db19-1174 |
0.421 |
|
| 2020 |
Ramirez AK, Dankel SN, Rastegarpanah B, Cai W, Xue R, Crovella M, Tseng YH, Kahn CR, Kasif S. Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity. Nature Communications. 11: 2117. PMID 32355218 DOI: 10.1038/S41467-020-16019-9 |
0.558 |
|
| 2020 |
Shamsi F, Xue R, Huang TL, Lundh M, Liu Y, Leiria LO, Lynes MD, Kempf E, Wang CH, Sugimoto S, Nigro P, Landgraf K, Schulz T, Li Y, Emanuelli B, ... ... Kahn CR, et al. FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis. Nature Communications. 11: 1421. PMID 32184391 DOI: 10.1038/S41467-020-15055-9 |
0.327 |
|
| 2020 |
Batista TM, Dagdeviren S, Carroll SH, Cai W, Melnik VY, Noh HL, Saengnipanthkul S, Kim JK, Kahn CR, Lee RT. Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver. Proceedings of the National Academy of Sciences of the United States of America. PMID 32156724 DOI: 10.1073/Pnas.1922370117 |
0.711 |
|
| 2020 |
Softic S, Stanhope KL, Boucher J, Divanovic S, Lanaspa MA, Johnson RJ, Kahn CR. Fructose and hepatic insulin resistance. Critical Reviews in Clinical Laboratory Sciences. 1-15. PMID 31935149 DOI: 10.1080/10408363.2019.1711360 |
0.568 |
|
| 2020 |
Batista TM, Albrechtsen NJW, Zierath JR, Mann M, Kahn CR. 298-OR: Disruption of Multiple Cell-Autonomous Protein Phosphorylation Networks Underlies Muscle Insulin Resistance in Type 2 Diabetes Diabetes. 69. DOI: 10.2337/Db20-298-Or |
0.526 |
|
| 2020 |
Brandao B, Sakaguchi M, Batista TM, Qian W, Kahn CR. 207-OR: Liver-Preadipocyte Cross Talk Reverses Lipodystrophy-Induced Insulin Resistance Diabetes. 69. DOI: 10.2337/Db20-207-Or |
0.502 |
|
| 2020 |
Nagao H, Cai W, Batista TM, Pan H, Dreyfuss J, Kahn CR. 1737-P: Defining Distinct Actions of Insulin and IGF1 Receptors and Their Extra and Intracellular Domains at the Level of the Phosphoproteome Diabetes. 69. DOI: 10.2337/Db20-1737-P |
0.659 |
|
| 2020 |
Haider N, Lebastchi J, Batista TM, Knowles J, Pan H, Dreyfuss J, Kahn CR. 1733-P: Phosphoproteomic Analysis of Insulin Action Using Human IPS-Derived Myoblasts Reveals Important Interactions between Differences Based on Insulin Sensitivity and Sex Diabetes. 69. DOI: 10.2337/Db20-1733-P |
0.513 |
|
| 2019 |
Softic S, Meyer JG, Wang GX, Gupta MK, Batista TM, Lauritzen HPMM, Fujisaka S, Serra D, Herrero L, Willoughby J, Fitzgerald K, Ilkayeva O, Newgard CB, Gibson BW, Schilling B, ... ... Kahn CR, et al. Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins. Cell Metabolism. 30: 735-753.e4. PMID 31577934 DOI: 10.1016/J.Cmet.2019.09.003 |
0.405 |
|
| 2019 |
Kahn CR, Wang G, Lee KY. Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome. The Journal of Clinical Investigation. 129: 3990-4000. PMID 31573548 DOI: 10.1172/Jci129187 |
0.351 |
|
| 2019 |
Li Q, Fu J, Xia Y, Qi W, Ishikado A, Park K, Yokomizo H, Huang Q, Cai W, Rask-Madsen C, Kahn CR, King GL. Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes. Nature Communications. 10: 4427. PMID 31562314 DOI: 10.1038/S41467-019-12368-2 |
0.716 |
|
| 2019 |
Hochreuter MY, Altıntaş A, Garde C, Emanuelli B, Kahn CR, Zierath JR, Vienberg S, Barrès R. Identification of two microRNA nodes as potential cooperative modulators of liver metabolism. Hepatology Research : the Official Journal of the Japan Society of Hepatology. PMID 31408567 DOI: 10.1111/Hepr.13419 |
0.432 |
|
| 2019 |
Li ME, Lauritzen HPMM, O'Neill BT, Wang CH, Cai W, Brandao BB, Sakaguchi M, Tao R, Hirshman MF, Softic S, Kahn CR. Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism. Nature Communications. 10: 3412. PMID 31363081 DOI: 10.1038/S41467-019-11265-Y |
0.614 |
|
| 2019 |
Huang Q, Kahn CR, Altindis E. Viral Hormones: Expanding Dimensions in Endocrinology. Endocrinology. PMID 31310273 DOI: 10.1210/En.2019-00271 |
0.364 |
|
| 2019 |
Batista TM, Cederquist CT, Kahn CR. The insulin receptor goes nuclear. Cell Research. PMID 31160720 DOI: 10.1038/S41422-019-0185-0 |
0.521 |
|
| 2019 |
Wang G, Meyer JG, Cai W, Softic S, Li ME, Verdin E, Newgard C, Schilling B, Kahn CR. Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation. Molecular Cell. PMID 31000437 DOI: 10.1016/J.Molcel.2019.03.021 |
0.663 |
|
| 2019 |
Sakaguchi M, Cai W, Wang CH, Cederquist CT, Damasio M, Homan EP, Batista T, Ramirez AK, Gupta MK, Steger M, Wewer Albrechtsen NJ, Singh SK, Araki E, Mann M, Enerbäck S, ... Kahn CR, et al. FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism. Nature Communications. 10: 1582. PMID 30952843 DOI: 10.1038/S41467-019-09418-0 |
0.696 |
|
| 2019 |
Gonçalves DA, Silveira WA, Manfredi LH, Graça FA, Armani A, Bertaggia E, O Neill BT, Lautherbach N, Machado J, Nogara L, Pereira MG, Arcidiacono D, Realdon S, Kahn CR, Sandri M, et al. Insulin/IGF1 signalling mediates the effects of β -adrenergic agonist on muscle proteostasis and growth. Journal of Cachexia, Sarcopenia and Muscle. PMID 30932373 DOI: 10.1002/Jcsm.12395 |
0.382 |
|
| 2019 |
Batista TM, Garcia-Martin R, Cai W, Konishi M, O'Neill BT, Sakaguchi M, Kim JH, Jung DY, Kim JK, Kahn CR. Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo. Cell Reports. 26: 3429-3443.e3. PMID 30893613 DOI: 10.1016/J.Celrep.2019.02.081 |
0.698 |
|
| 2019 |
Ramirez AK, Dankel S, Cai W, Sakaguchi M, Kasif S, Kahn CR. Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes. Molecular Metabolism. PMID 30795914 DOI: 10.1016/J.Molmet.2019.01.006 |
0.654 |
|
| 2019 |
Soto M, Cai W, Konishi M, Kahn CR. Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior. Proceedings of the National Academy of Sciences of the United States of America. PMID 30765523 DOI: 10.1073/Pnas.1817391116 |
0.701 |
|
| 2019 |
Wardelmann K, Blümel S, Rath M, Alfine E, Chudoba C, Schell M, Cai W, Hauffe R, Warnke K, Flore T, Ritter K, Weiß J, Kahn CR, Kleinridders A. Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain. Molecular Metabolism. PMID 30670351 DOI: 10.1016/J.Molmet.2019.01.001 |
0.647 |
|
| 2019 |
Guerra C, Navarro P, Valverde AM, Arribas M, Brüning J, Kozak LP, Kahn CR, Benito M. Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance. The Journal of Clinical Investigation. 129: 437. PMID 30601142 DOI: 10.1172/Jci13103 |
0.597 |
|
| 2019 |
BATISTA TM, CAI W, BRANDAO B, KAHN CR. 35-OR: Physiological Insulin Regulates Alternative mRNA Splicing in Liver and Muscle at Multiple Levels Diabetes. 68: 35-OR. DOI: 10.2337/Db19-35-Or |
0.713 |
|
| 2019 |
BRANDAO B, LI ME, CAI W, BATISTA TM, HIRSHMAN MF, GOODYEAR LJ, KAHN CR. 291-OR: Exercise Modulates Glucose Metabolism in Part through Changes in the Gut Microbiome Diabetes. 68: 291-OR. DOI: 10.2337/Db19-291-Or |
0.598 |
|
| 2019 |
CAI W, BATISTA TM, MARTIN RG, RAMIREZ A, KONISHI M, BRIAN T. O, KIM JK, KAHN CR. 1805-P: Insulin Regulates a Broad Network of Gene Expression in the Brain to Regulated Brain Metabolism and Neurotransmission Diabetes. 68: 1805-P. DOI: 10.2337/Db19-1805-P |
0.658 |
|
| 2019 |
WANG G, CAI W, BATISTA TM, SOFTIC S, KAHN CR. 1785-P: Mice with Muscle-Specific Insulin Receptor Overexpression Are Protected from Diet-Induced Obesity and Glucose Intolerance but Develop Post-Receptor Insulin Resistance Diabetes. 68: 1785-P. DOI: 10.2337/Db19-1785-P |
0.72 |
|
| 2018 |
Meyer JG, Softic S, Basisty N, Rardin MJ, Verdin E, Gibson BW, Ilkayeva O, Newgard CB, Kahn CR, Schilling B. Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose. Plos One. 13: e0208973. PMID 30586434 DOI: 10.1371/Journal.Pone.0208973 |
0.538 |
|
| 2018 |
Lee KY, Luong Q, Sharma R, Dreyfuss JM, Ussar S, Kahn CR. Developmental and functional heterogeneity of white adipocytes within a single fat depot. The Embo Journal. PMID 30530479 DOI: 10.15252/Embj.201899291 |
0.414 |
|
| 2018 |
O'Neill BT, Bhardwaj G, Penniman CM, Krumpoch MT, Suarez Beltran PA, Klaus K, Poro K, Li M, Pan H, Dreyfuss JM, Nair KS, Kahn CR. FoxO Transcription Factors are Critical Regulators of Diabetes-Related Muscle Atrophy. Diabetes. PMID 30523026 DOI: 10.2337/Db18-0416 |
0.441 |
|
| 2018 |
Bou Karam J, Cai W, Mohamed R, Huang T, Meng L, Homan EP, Dirice E, Kahn CR, El Ouaamari A. TRPV1 neurons regulate β-cell function in a sex-dependent manner. Molecular Metabolism. 18: 60-67. PMID 30473098 DOI: 10.1016/J.Molmet.2018.10.002 |
0.551 |
|
| 2018 |
Rao TN, Gupta MK, Softic S, Wang LD, Jang YC, Thomou T, Bezy O, Kulkarni RN, Kahn CR, Wagers AJ. Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors. The Embo Journal. PMID 30446598 DOI: 10.15252/Embj.2018100409 |
0.314 |
|
| 2018 |
Weingarten G, Ben Yaakov A, Dror E, Russ J, Magin TM, Kahn CR, Wertheimer E. Insulin receptor plays a central role in skin carcinogenesis by regulating cytoskeleton assembly. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800847R. PMID 30332298 DOI: 10.1096/Fj.201800847R |
0.489 |
|
| 2018 |
Soto M, Herzog C, Pacheco JA, Fujisaka S, Bullock K, Clish CB, Kahn CR. Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism. Molecular Psychiatry. PMID 29910467 DOI: 10.1038/S41380-018-0086-5 |
0.491 |
|
| 2018 |
Solheim MH, Winnay JN, Batista TM, Molven A, Njølstad PR, Kahn CR. Mice Carrying a Dominant-Negative Human PI 3-Kinase Mutation are Protected From Obesity and Hepatic Steatosis But Not Diabetes. Diabetes. PMID 29724723 DOI: 10.2337/Db17-1509 |
0.5 |
|
| 2018 |
Kleinridders A, Ferris HA, Reyzer ML, Rath M, Soto M, Manier ML, Spraggins J, Yang Z, Stanton RC, Caprioli RM, Kahn CR. Regional differences in brain glucose metabolism determined by imaging mass spectrometry. Molecular Metabolism. PMID 29681509 DOI: 10.1016/J.Molmet.2018.03.013 |
0.323 |
|
| 2018 |
Cai W, Xue C, Sakaguchi M, Konishi M, Shirazian A, Ferris HA, Li M, Yu R, Kleinridders A, Pothos EN, Kahn CR. Insulin regulates astrocyte gliotransmission and modulates behavior. The Journal of Clinical Investigation. PMID 29664737 DOI: 10.1172/Jci99366 |
0.685 |
|
| 2018 |
Fujisaka S, Avila-Pacheco J, Soto M, Kostic A, Dreyfuss JM, Pan H, Ussar S, Altindis E, Li N, Bry L, Clish CB, Kahn CR. Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites. Cell Reports. 22: 3072-3086. PMID 29539432 DOI: 10.1016/J.Celrep.2018.02.060 |
0.339 |
|
| 2018 |
Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR. Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. The Journal of Clinical Investigation. 128: 1199. PMID 29493547 DOI: 10.1172/JCI99009 |
0.413 |
|
| 2018 |
Altindis E, Cai W, Sakaguchi M, Zhang F, GuoXiao W, Liu F, De Meyts P, Gelfanov V, Pan H, DiMarchi R, Kahn CR. Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions. Proceedings of the National Academy of Sciences of the United States of America. PMID 29467286 DOI: 10.1073/Pnas.1721117115 |
0.694 |
|
| 2018 |
Soto M, Orliaguet L, Reyzer ML, Manier ML, Caprioli RM, Kahn CR. Pyruvate induces torpor in obese mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311303 DOI: 10.1073/Pnas.1717507115 |
0.344 |
|
| 2018 |
ALTINDIS E, VOMUND AN, CHOW I, DAMASIO M, KWOK W, UNANUE ER, KAHN CR. Identification of Cross Reactive Insulin Immunogenic Epitopes from Commensal Gut Microbes Diabetes. 67: 95-OR. DOI: 10.2337/Db18-95-Or |
0.41 |
|
| 2018 |
SAKAGUCHI M, CAI W, WANG C, BATISTA TM, ARAKI E, KAHN CR. FoxK1/K2 Are New, Important Components of IR and IGF1R Signaling and Control of Cell Proliferation and Metabolism Diabetes. 67: 356-OR. DOI: 10.2337/Db18-356-Or |
0.658 |
|
| 2018 |
Brandao BB, Altindis E, Martin RG, Kahn CR. Serum Exosomal Proteins—A New Component of Intercellular Communication in Metabolism Diabetes. 67. DOI: 10.2337/Db18-354-Or |
0.479 |
|
| 2018 |
WANG G, MEYER JG, CAI W, LI ME, SOFTIC S, KAHN CR. Sirt5 Plays a Critical Role in Mitochondrial Protein Acylation and Mitochondrial Metabolic Homeostasis in Brown Fat Diabetes. 67: 274-OR. DOI: 10.2337/Db18-274-Or |
0.58 |
|
| 2017 |
Chaudhari A, Ejeskär K, Wettergren Y, Kahn CR, Rotter Sopasakis V. Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity. F1000research. 6: 1600. PMID 29983910 DOI: 10.12688/F1000Research.12418.2 |
0.578 |
|
| 2017 |
Ramirez AK, Lynes MD, Shamsi F, Xue R, Tseng YH, Kahn CR, Kasif S, Dreyfuss JM. Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes. Cell Reports. 21: 3040-3048. PMID 29241534 DOI: 10.1016/J.Celrep.2017.11.065 |
0.338 |
|
| 2017 |
Viana-Huete V, Guillén C, García G, Fernández S, García-Aguilar A, Kahn CR, Benito M. Male brown fat-specific double knockout of IGFIR/IR: Atrophy, mitochondrial fission failure, impaired thermogenesis and obesity. Endocrinology. PMID 29040448 DOI: 10.1210/en.2017-00738 |
0.371 |
|
| 2017 |
Sajan MP, Hansen BC, Higgs MG, Kahn CR, Braun U, Leitges M, Park CR, Diamond DM, Farese RV. Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease. Neurobiology of Aging. PMID 29032894 DOI: 10.1016/J.Neurobiolaging.2017.09.001 |
0.343 |
|
| 2017 |
Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR. Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. The Journal of Clinical Investigation. PMID 28972537 DOI: 10.1172/Jci94585 |
0.499 |
|
| 2017 |
Konishi M, Sakaguchi M, Lockhart SM, Cai W, Li ME, Homan EP, Rask-Madsen C, Kahn CR. Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923931 DOI: 10.1073/Pnas.1710625114 |
0.721 |
|
| 2017 |
Lee KY, Sharma R, Gase G, Ussar S, Li Y, Welch L, Berryman DE, Kispert A, Bluher M, Kahn CR. Tbx15 Defines a Glycolytic Subpopulation and White Adipocyte Heterogeneity. Diabetes. PMID 28847884 DOI: 10.2337/Db17-0218 |
0.358 |
|
| 2017 |
Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, et al. Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling. Nature Medicine. PMID 28604704 DOI: 10.1038/Nm.4346 |
0.302 |
|
| 2017 |
Merry TL, Kuhlow D, Laube B, Pöhlmann D, Pfeiffer AFH, Kahn CR, Ristow M, Zarse K. Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan. Aging Cell. PMID 28544360 DOI: 10.1111/Acel.12610 |
0.565 |
|
| 2017 |
Kahn CR, Ussar S. Response to Comment on Ussar et al. Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor. Diabetes 2017;66:886-896. Diabetes. 66: e6. PMID 28507218 DOI: 10.2337/Dbi17-0003 |
0.415 |
|
| 2017 |
Wang X, Häring MF, Rathjen T, Lockhart SM, Sørensen D, Ussar S, Rasmussen LM, Bertagnolli MM, Kahn CR, Rask-Madsen C. Insulin resistance in vascular endothelial cells promotes intestinal tumour formation. Oncogene. PMID 28459466 DOI: 10.1038/onc.2017.107 |
0.419 |
|
| 2017 |
Ueki K, Fruman DA, Yballe CM, Fasshauer M, Klein J, Asano T, Cantley LC, Kahn CR. Positive and negative roles of p85α and p85β regulatory subunits of phosphoinositide 3-kinase in insulin signaling. The Journal of Biological Chemistry. 292: 5608. PMID 28363934 DOI: 10.1074/Jbc.A117.305602 |
0.464 |
|
| 2017 |
Cai W, Sakaguchi M, Kleinridders A, Gonzalez-Del Pino G, Dreyfuss JM, O'Neill BT, Ramirez AK, Pan H, Winnay JN, Boucher J, Eck MJ, Kahn CR. Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nature Communications. 8: 14892. PMID 28345670 DOI: 10.1038/Ncomms14892 |
0.642 |
|
| 2017 |
Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, Gorden P, Kahn CR. Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature. PMID 28199304 DOI: 10.1038/Nature21365 |
0.312 |
|
| 2017 |
Ferris HA, Perry RJ, Moreira GV, Shulman GI, Horton JD, Kahn CR. Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096339 DOI: 10.1073/Pnas.1620506114 |
0.308 |
|
| 2017 |
Ussar S, Haering MF, Fujisaka S, Lutter D, Lee KY, Li N, Gerber GK, Bry L, Kahn CR. Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor. Diabetes. PMID 28096258 DOI: 10.2337/Db15-1349 |
0.522 |
|
| 2017 |
Sakaguchi M, Fujisaka S, Cai W, Winnay JN, Konishi M, O'Neill BT, Li M, García-Martín R, Takahashi H, Hu J, Kulkarni RN, Kahn CR. Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor. Cell Metabolism. PMID 28065828 DOI: 10.1016/J.Cmet.2016.12.008 |
0.713 |
|
| 2016 |
Entingh AJ, Taniguchi CM, Kahn CR. Bi-directional regulation of brown fat adipogenesis by the insulin receptor. The Journal of Biological Chemistry. 291: 27434. PMID 28039334 DOI: 10.1074/Jbc.A116.303056 |
0.708 |
|
| 2016 |
Taniguchi CM, Ueki K, Kahn CR. Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. The Journal of Clinical Investigation. 126: 4387. PMID 27801676 DOI: 10.1172/JCI90689 |
0.552 |
|
| 2016 |
Fujisaka S, Ussar S, Clish C, Devkota S, Dreyfuss JM, Sakaguchi M, Soto M, Konishi M, Softic S, Altindis E, Li N, Gerber G, Bry L, Kahn CR. Antibiotic effects on gut microbiota and metabolism are host dependent. The Journal of Clinical Investigation. PMID 27775551 DOI: 10.1172/Jci86674 |
0.473 |
|
| 2016 |
Entingh-Pearsall A, Kahn CR. Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I. The Journal of Biological Chemistry. 291: 22339-22340. PMID 27742877 DOI: 10.1074/Jbc.M313201200 |
0.554 |
|
| 2016 |
O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, ... ... Kahn CR, et al. Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. The Journal of Clinical Investigation. PMID 27525440 DOI: 10.1172/Jci86522 |
0.623 |
|
| 2016 |
García-Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, Jastroch M, Johansson P, Ninkovic J, Yi CX, Le Thuc O, Szigeti-Buck K, Cai W, Meyer CW, Pfluger PT, ... ... Kahn CR, et al. Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell. 166: 867-80. PMID 27518562 DOI: 10.1016/J.Cell.2016.07.028 |
0.67 |
|
| 2016 |
Palsgaard J, Emanuelli B, Winnay JN, Sumara G, Karsenty G, Kahn CR. Cross-talk between insulin and Wnt signaling in preadipocytes. ROLE OF Wnt CO-RECEPTOR LDL RECEPTOR-RELATED PROTEIN-5 (LRP5). The Journal of Biological Chemistry. 291: 16878. PMID 27496960 DOI: 10.1074/Jbc.A111.337048 |
0.581 |
|
| 2016 |
Stoeckel LE, Arvanitakis Z, Gandy S, Small D, Kahn CR, Pascual-Leone A, Pawlyk A, Sherwin R, Smith P. "White Paper" meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction. F1000research. 5: 353. PMID 27303627 DOI: 10.12688/F1000Research.8300.2 |
0.412 |
|
| 2016 |
Ferris HA, Kahn CR. Unraveling the Paradox of Selective Insulin Resistance in the Liver: the Brain-Liver Connection. Diabetes. 65: 1481-3. PMID 27222392 DOI: 10.2337/Dbi16-0010 |
0.538 |
|
| 2016 |
Boucher J, Softic S, El Ouaamari A, Krumpoch MT, Kleinridders A, Kulkarni RN, O'Neill BT, Kahn CR. Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function. Diabetes. PMID 27207537 DOI: 10.2337/Db16-0212 |
0.528 |
|
| 2016 |
Softic S, Boucher J, Solheim MH, Fujisaka S, Haering MF, Homan EP, Winnay J, Perez-Atayde AR, Kahn CR. Lipodystrophy Due to Adipose Tissue Specific Insulin Receptor Knockout Results in Progressive NAFLD. Diabetes. PMID 27207510 DOI: 10.2337/Db16-0213 |
0.417 |
|
| 2016 |
Winnay JN, Solheim MH, Dirice E, Sakaguchi M, Noh HL, Kang HJ, Takahashi H, Chudasama KK, Kim JK, Molven A, Kahn CR, Njølstad PR. PI3-kinase mutation linked to insulin and growth factor resistance in vivo. The Journal of Clinical Investigation. PMID 26974159 DOI: 10.1172/Jci84005 |
0.536 |
|
| 2016 |
Burkart AM, Tan K, Warren L, Iovino S, Hughes KJ, Kahn CR, Patti ME. Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function. Scientific Reports. 6: 22788. PMID 26948272 DOI: 10.1038/Srep22788 |
0.482 |
|
| 2016 |
Viana-Huete V, Guillén C, García-Aguilar A, García G, Fernández S, Kahn CR, Benito M. Essential role of IGFIR in the onset of male brown fat thermogenic function: Regulation of glucose homeostasis by differential organ-specific insulin sensitivity. Endocrinology. en20151623. PMID 26910308 DOI: 10.1210/en.2015-1623 |
0.434 |
|
| 2016 |
Softic S, Cohen DE, Kahn CR. Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease. Digestive Diseases and Sciences. PMID 26856717 DOI: 10.1007/S10620-016-4054-0 |
0.413 |
|
| 2016 |
Iovino S, Burkart AM, Warren L, Patti ME, Kahn CR. Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831110 DOI: 10.1073/Pnas.1525665113 |
0.559 |
|
| 2016 |
Stoeckel LE, Arvanitakis Z, Gandy S, Small D, Kahn CR, Pascual-Leone A, Pawlyk A, Sherwin R, Smith P. “White Paper” meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction F1000research. 5: 353. DOI: 10.12688/F1000Research.8300.1 |
0.412 |
|
| 2016 |
Taniguchi C, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley L, Kahn C. Divergent Regulation of Hepatic Glucose and Lipid Metabolism by Phosphoinositide 3-Kinase via Akt and PKCλ/ζ Cell Metabolism. 23: 386. DOI: 10.1016/J.Cmet.2016.01.016 |
0.613 |
|
| 2015 |
DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman GI, Simonson DC, Testa MA, Weiss R. Type 2 diabetes mellitus. Nature Reviews. Disease Primers. 1: 15019. PMID 27189025 DOI: 10.1038/nrdp.2015.19 |
0.393 |
|
| 2015 |
Lagarrigue S, Lopez-Mejia IC, Denechaud PD, Escoté X, Castillo-Armengol J, Jimenez V, Chavey C, Giralt A, Lai Q, Zhang L, Martinez-Carreres L, Delacuisine B, Annicotte JS, Blanchet E, Huré S, ... ... Kahn CR, et al. CDK4 is an essential insulin effector in adipocytes. The Journal of Clinical Investigation. PMID 26657864 DOI: 10.1172/Jci81480 |
0.584 |
|
| 2015 |
Fukui K, Ferris HA, Kahn CR. Effect of Cholesterol Reduction on Receptor Signaling in Neurons. The Journal of Biological Chemistry. 290: 26383-92. PMID 26370080 DOI: 10.1074/Jbc.M115.664367 |
0.424 |
|
| 2015 |
Li M, Vienberg SG, Bezy O, O'Neill BT, Kahn CR. Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism. Diabetes. 64: 4023-32. PMID 26307588 DOI: 10.2337/Db14-1891 |
0.547 |
|
| 2015 |
Lee KY, Singh MK, Ussar S, Wetzel P, Hirshman MF, Goodyear LJ, Kispert A, Kahn CR. Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nature Communications. 6: 8054. PMID 26299309 DOI: 10.1038/Ncomms9054 |
0.324 |
|
| 2015 |
O-Sullivan I, Zhang W, Wasserman DH, Liew CW, Liu J, Paik J, DePinho RA, Stolz DB, Kahn CR, Schwartz MW, Unterman TG. Erratum: FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization. Nature Communications. 6: 7861. PMID 26206703 DOI: 10.1038/Ncomms8861 |
0.464 |
|
| 2015 |
O'Neill BT, Lauritzen HP, Hirshman MF, Smyth G, Goodyear LJ, Kahn CR. Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis. Cell Reports. 11: 1220-35. PMID 25981038 DOI: 10.1016/J.Celrep.2015.04.037 |
0.543 |
|
| 2015 |
O-Sullivan I, Zhang W, Wasserman DH, Liew CW, Liu J, Paik J, DePinho RA, Stolz DB, Kahn CR, Schwartz MW, Unterman TG. FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization. Nature Communications. 6: 7079. PMID 25963540 DOI: 10.1038/Ncomms8079 |
0.559 |
|
| 2015 |
Balhara B, Burkart A, Topcu V, Lee YK, Cowan C, Kahn CR, Patti ME. Severe insulin resistance alters metabolism in mesenchymal progenitor cells. Endocrinology. 156: 2039-48. PMID 25811318 DOI: 10.1210/En.2014-1403 |
0.563 |
|
| 2015 |
Kleinridders A, Cai W, Cappellucci L, Ghazarian A, Collins WR, Vienberg SG, Pothos EN, Kahn CR. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. Proceedings of the National Academy of Sciences of the United States of America. 112: 3463-8. PMID 25733901 DOI: 10.1073/Pnas.1500877112 |
0.654 |
|
| 2015 |
Vienberg SG, Kleinridders A, Suzuki R, Kahn CR. Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity. Molecular Metabolism. 4: 144-50. PMID 25685701 DOI: 10.1016/J.Molmet.2014.11.003 |
0.324 |
|
| 2015 |
Emanuelli B, Vienberg SG, Smyth G, Cheng C, Stanford KI, Arumugam M, Michael MD, Adams AC, Kharitonenkov A, Kahn CR. Interplay between FGF21 and insulin action in the liver regulates metabolism. The Journal of Clinical Investigation. 125: 458. PMID 25654556 DOI: 10.1172/JCI80223 |
0.398 |
|
| 2014 |
Boucher J, Charalambous M, Zarse K, Mori MA, Kleinridders A, Ristow M, Ferguson-Smith AC, Kahn CR. Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes. Proceedings of the National Academy of Sciences of the United States of America. 111: 14512-7. PMID 25246545 DOI: 10.1073/Pnas.1415475111 |
0.505 |
|
| 2014 |
Pensa S, Lloyd-Lewis B, Sargeant TJ, Resemann HK, Kahn CR, Watson CJ. Signal transducer and activator of transcription 3 and the phosphatidylinositol 3-kinase regulatory subunits p55α and p50α regulate autophagy in vivo Febs Journal. 281: 4557-4567. PMID 25205393 DOI: 10.1111/Febs.13035 |
0.307 |
|
| 2014 |
Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science Translational Medicine. 6: 247ra103. PMID 25080478 DOI: 10.1126/Scitranslmed.3008490 |
0.318 |
|
| 2014 |
Iovino S, Burkart AM, Kriauciunas K, Warren L, Hughes KJ, Molla M, Lee YK, Patti ME, Kahn CR. Genetic insulin resistance is a potent regulator of gene expression and proliferation in human iPS cells. Diabetes. 63: 4130-42. PMID 25059784 DOI: 10.2337/Db14-0109 |
0.56 |
|
| 2014 |
Vernochet C, Damilano F, Mourier A, Bezy O, Mori MA, Smyth G, Rosenzweig A, Larsson NG, Kahn CR. Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4408-19. PMID 25005176 DOI: 10.1096/Fj.14-253971 |
0.429 |
|
| 2014 |
Thrailkill K, Bunn RC, Lumpkin C, Wahl E, Cockrell G, Morris L, Kahn CR, Fowlkes J, Nyman JS. Loss of insulin receptor in osteoprogenitor cells impairs structural strength of bone. Journal of Diabetes Research. 2014: 703589. PMID 24963495 DOI: 10.1155/2014/703589 |
0.409 |
|
| 2014 |
Kleinridders A, Ferris HA, Cai W, Kahn CR. Insulin action in brain regulates systemic metabolism and brain function. Diabetes. 63: 2232-43. PMID 24931034 DOI: 10.2337/Db14-0568 |
0.699 |
|
| 2014 |
Emanuelli B, Vienberg SG, Smyth G, Cheng C, Stanford KI, Arumugam M, Michael MD, Adams AC, Kharitonenkov A, Kahn CR. Interplay between FGF21 and insulin action in the liver regulates metabolism. The Journal of Clinical Investigation. 124: 515-27. PMID 24401271 DOI: 10.1172/Jci67353 |
0.502 |
|
| 2014 |
Winnay JN, Dirice E, Liew CW, Kulkarni RN, Kahn CR. p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 111: 1192-7. PMID 24395790 DOI: 10.1073/Pnas.1322564111 |
0.411 |
|
| 2014 |
Boucher J, Kleinridders A, Kahn CR. Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harbor Perspectives in Biology. 6. PMID 24384568 DOI: 10.1101/Cshperspect.A009191 |
0.552 |
|
| 2013 |
Kleinridders A, Lauritzen HP, Ussar S, Christensen JH, Mori MA, Bross P, Kahn CR. Leptin regulation of Hsp60 impacts hypothalamic insulin signaling. The Journal of Clinical Investigation. 123: 4667-80. PMID 24084737 DOI: 10.1172/Jci67615 |
0.535 |
|
| 2013 |
Kang HW, Ozdemir C, Kawano Y, LeClair KB, Vernochet C, Kahn CR, Hagen SJ, Cohen DE. Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice. The Journal of Biological Chemistry. 288: 33376-86. PMID 24072708 DOI: 10.1074/Jbc.M113.481408 |
0.361 |
|
| 2013 |
Jing E, O'Neill BT, Rardin MJ, Kleinridders A, Ilkeyeva OR, Ussar S, Bain JR, Lee KY, Verdin EM, Newgard CB, Gibson BW, Kahn CR. Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes. 62: 3404-17. PMID 23835326 DOI: 10.2337/Db12-1650 |
0.565 |
|
| 2013 |
Chudasama KK, Winnay J, Johansson S, Claudi T, König R, Haldorsen I, Johansson B, Woo JR, Aarskog D, Sagen JV, Kahn CR, Molven A, Njølstad PR. SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling. American Journal of Human Genetics. 93: 150-7. PMID 23810379 DOI: 10.1016/J.Ajhg.2013.05.023 |
0.46 |
|
| 2013 |
Gahete MD, Córdoba-Chacón J, Lin Q, Brüning JC, Kahn CR, Castaño JP, Christian H, Luque RM, Kineman RD. Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms. Endocrinology. 154: 2410-20. PMID 23671263 DOI: 10.1210/En.2013-1261 |
0.549 |
|
| 2013 |
Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW. Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proceedings of the National Academy of Sciences of the United States of America. 110: 6601-6. PMID 23576753 DOI: 10.1073/Pnas.1302961110 |
0.688 |
|
| 2012 |
Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, An D, Lee KY, Ilkayeva OR, Zingaretti CM, Emanuelli B, Smyth G, Cinti S, Newgard CB, Gibson BW, ... ... Kahn CR, et al. Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. Cell Metabolism. 16: 765-76. PMID 23168219 DOI: 10.1016/J.Cmet.2012.10.016 |
0.406 |
|
| 2012 |
Ferris HA, Kahn CR. New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it. The Journal of Clinical Investigation. 122: 3854-7. PMID 23093783 DOI: 10.1172/Jci66180 |
0.446 |
|
| 2012 |
Lee KY, Kahn CR. Turning on brown fat and muscle metabolism: hedging your bets. Cell. 151: 248-50. PMID 23063118 DOI: 10.1016/J.Cell.2012.09.025 |
0.369 |
|
| 2012 |
Rask-Madsen C, Kahn CR. Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 2052-9. PMID 22895666 DOI: 10.1161/Atvbaha.111.241919 |
0.455 |
|
| 2012 |
Ussar S, Bezy O, Blüher M, Kahn CR. Glypican-4 enhances insulin signaling via interaction with the insulin receptor and serves as a novel adipokine. Diabetes. 61: 2289-98. PMID 22751693 DOI: 10.2337/Db11-1395 |
0.59 |
|
| 2012 |
Boucher J, Mori MA, Lee KY, Smyth G, Liew CW, Macotela Y, Rourk M, Bluher M, Russell SJ, Kahn CR. Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling. Nature Communications. 3: 902. PMID 22692545 DOI: 10.1038/Ncomms1905 |
0.552 |
|
| 2012 |
Cypess AM, Chen YC, Sze C, Wang K, English J, Chan O, Holman AR, Tal I, Palmer MR, Kolodny GM, Kahn CR. Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proceedings of the National Academy of Sciences of the United States of America. 109: 10001-5. PMID 22665804 DOI: 10.1073/Pnas.1207911109 |
0.354 |
|
| 2012 |
Macotela Y, Emanuelli B, Mori MA, Gesta S, Schulz TJ, Tseng Y, Kahn CR. Intrinsic Differences in Adipocyte Precursor Cells From Different White Fat Depots Diabetes. 61: 1691-1699. PMID 22596050 DOI: 10.2337/Db11-1753 |
0.367 |
|
| 2012 |
Roth J, Qureshi S, Whitford I, Vranic M, Kahn CR, Fantus IG, Dirks JH. Insulin's discovery: new insights on its ninetieth birthday. Diabetes/Metabolism Research and Reviews. 28: 293-304. PMID 22576778 DOI: 10.1002/Dmrr.2300 |
0.472 |
|
| 2012 |
Kiefer FW, Vernochet C, O'Brien P, Spoerl S, Brown JD, Nallamshetty S, Zeyda M, Stulnig TM, Cohen DE, Kahn CR, Plutzky J. Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Nature Medicine. 18: 918-25. PMID 22561685 DOI: 10.1038/Nm.2757 |
0.392 |
|
| 2012 |
Zarse K, Schmeisser S, Groth M, Priebe S, Beuster G, Kuhlow D, Guthke R, Platzer M, Kahn CR, Ristow M. Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metabolism. 15: 451-65. PMID 22482728 DOI: 10.1016/J.Cmet.2012.02.013 |
0.37 |
|
| 2012 |
Schilling B, Rardin MJ, MacLean BX, Zawadzka AM, Frewen BE, Cusack MP, Sorensen DJ, Bereman MS, Jing E, Wu CC, Verdin E, Kahn CR, Maccoss MJ, Gibson BW. Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Molecular & Cellular Proteomics : McP. 11: 202-14. PMID 22454539 DOI: 10.1074/Mcp.M112.017707 |
0.452 |
|
| 2012 |
Lu M, Wan M, Leavens KF, Chu Q, Monks BR, Fernandez S, Ahima RS, Ueki K, Kahn CR, Birnbaum MJ. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nature Medicine. 18: 388-95. PMID 22344295 DOI: 10.1038/Nm.2686 |
0.511 |
|
| 2012 |
Palsgaard J, Emanuelli B, Winnay JN, Sumara G, Karsenty G, Kahn CR. Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). The Journal of Biological Chemistry. 287: 12016-26. PMID 22337886 DOI: 10.1074/Jbc.M111.337048 |
0.579 |
|
| 2012 |
Halperin F, Lopez X, Manning R, Kahn CR, Kulkarni RN, Goldfine AB. Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans. Diabetes. 61: 301-9. PMID 22275085 DOI: 10.2337/Db11-1067 |
0.56 |
|
| 2012 |
Sajan MP, Nimal S, Mastorides S, Acevedo-Duncan M, Kahn CR, Fields AP, Braun U, Leitges M, Farese RV. Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι. Metabolism: Clinical and Experimental. 61: 459-69. PMID 22225955 DOI: 10.1016/J.Metabol.2011.12.008 |
0.415 |
|
| 2011 |
Gahete MD, Córdoba-Chacón J, Anadumaka CV, Lin Q, Brüning JC, Kahn CR, Luque RM, Kineman RD. Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner. Endocrinology. 152: 4825-37. PMID 21990313 DOI: 10.1210/En.2011-1447 |
0.578 |
|
| 2011 |
Lee KY, Gesta S, Boucher J, Wang XL, Kahn CR. The Differential Role of Hif1β/Arnt and the Hypoxic Response in Adipose Function, Fibrosis, and Inflammation Cell Metabolism. 14: 491-503. PMID 21982709 DOI: 10.1016/J.Cmet.2011.08.006 |
0.417 |
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| 2011 |
Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, Verdin EM, Kahn CR. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proceedings of the National Academy of Sciences of the United States of America. 108: 14608-13. PMID 21873205 DOI: 10.1073/Pnas.1111308108 |
0.622 |
|
| 2011 |
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, StanÄáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, ... ... Kahn CR, et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Molecular Cell. 44: 177-90. PMID 21856199 DOI: 10.1016/J.Molcel.2011.07.019 |
0.719 |
|
| 2011 |
Macotela Y, Emanuelli B, Bång AM, Espinoza DO, Boucher J, Beebe K, Gall W, Kahn CR. Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism. Plos One. 6: e21187. PMID 21731668 DOI: 10.1371/Journal.Pone.0021187 |
0.561 |
|
| 2011 |
Bezy O, Tran TT, Pihlajamäki J, Suzuki R, Emanuelli B, Winnay J, Mori MA, Haas J, Biddinger SB, Leitges M, Goldfine AB, Patti ME, King GL, Kahn CR. PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. The Journal of Clinical Investigation. 121: 2504-17. PMID 21576825 DOI: 10.1172/Jci46045 |
0.544 |
|
| 2011 |
Mori MA, Bezy O, Kahn CR. Metabolic Syndrome: Is Nlrp3 Inflammasome a Trigger or a Target of Insulin Resistance? Circulation Research. 108: 1160-1162. PMID 21566220 DOI: 10.1161/Res.0B013E318220B57B |
0.525 |
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| 2011 |
Sanchez-Alavez M, Osborn O, Tabarean IV, Holmberg KH, Eberwine J, Kahn CR, Bartfai T. Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. The Journal of Biological Chemistry. 286: 14983-90. PMID 21330367 DOI: 10.1074/Jbc.M110.188540 |
0.539 |
|
| 2011 |
Gesta S, Bezy O, Mori MA, Macotela Y, Lee KY, Kahn CR. Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration Proceedings of the National Academy of Sciences of the United States of America. 108: 2771-2776. PMID 21282637 DOI: 10.1073/Pnas.1019704108 |
0.356 |
|
| 2011 |
Kendrick AA, Choudhury M, Rahman SM, McCurdy CE, Friederich M, Van Hove JL, Watson PA, Birdsey N, Bao J, Gius D, Sack MN, Jing E, Kahn CR, Friedman JE, Jonscher KR. Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. The Biochemical Journal. 433: 505-14. PMID 21044047 DOI: 10.1042/Bj20100791 |
0.35 |
|
| 2011 |
Emkey R, Kahn CR. Molecular Aspects of Insulin Signaling Comprehensive Physiology. 413-433. DOI: 10.1002/Cphy.Cp070212 |
0.578 |
|
| 2010 |
Boucher J, Macotela Y, Bezy O, Mori MA, Kriauciunas K, Kahn CR. A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis. Science Signaling. 3: ra87. PMID 21139139 DOI: 10.1126/scisignal.2001173 |
0.43 |
|
| 2010 |
Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni RN, ... Kahn CR, et al. Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. Cell Metabolism. 12: 619-32. PMID 21109194 DOI: 10.1016/J.Cmet.2010.11.005 |
0.566 |
|
| 2010 |
Suzuki R, Lee K, Jing E, Biddinger SB, McDonald JG, Montine TJ, Craft S, Kahn CR. Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metabolism. 12: 567-79. PMID 21109190 DOI: 10.1016/J.Cmet.2010.11.006 |
0.48 |
|
| 2010 |
Welsh GI, Hale LJ, Eremina V, Jeansson M, Maezawa Y, Lennon R, Pons DA, Owen RJ, Satchell SC, Miles MJ, Caunt CJ, McArdle CA, Pavenstädt H, Tavaré JM, Herzenberg AM, ... Kahn CR, et al. Insulin signaling to the glomerular podocyte is critical for normal kidney function. Cell Metabolism. 12: 329-40. PMID 20889126 DOI: 10.1016/J.Cmet.2010.08.015 |
0.366 |
|
| 2010 |
Brothers KJ, Wu S, DiVall SA, Messmer MR, Kahn CR, Miller RS, Radovick S, Wondisford FE, Wolfe A. Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor. Cell Metabolism. 12: 295-305. PMID 20816095 DOI: 10.1016/J.Cmet.2010.06.010 |
0.546 |
|
| 2010 |
Vesterhus M, Raeder H, Kurpad AJ, Kawamori D, Molven A, Kulkarni RN, Kahn CR, Njølstad PR. Pancreatic function in carboxyl-ester lipase knockout mice. Pancreatology : Official Journal of the International Association of Pancreatology (Iap) ... [Et Al.]. 10: 467-76. PMID 20720448 DOI: 10.1159/000266284 |
0.397 |
|
| 2010 |
Mori MA, Liu M, Bezy O, Almind K, Shapiro H, Kasif S, Kahn CR. A Systems Biology Approach Identifies Inflammatory Abnormalities Between Mouse Strains Prior to Development of Metabolic Disease Diabetes. 59: 2960-2971. PMID 20713682 DOI: 10.2337/Db10-0367 |
0.394 |
|
| 2010 |
Divall SA, Williams TR, Carver SE, Koch L, Brüning JC, Kahn CR, Wondisford F, Radovick S, Wolfe A. Divergent roles of growth factors in the GnRH regulation of puberty in mice. The Journal of Clinical Investigation. 120: 2900-9. PMID 20628204 DOI: 10.1172/Jci41069 |
0.325 |
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| 2010 |
Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR. The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. Cancer Research. 70: 5305-15. PMID 20530665 DOI: 10.1158/0008-5472.Can-09-3399 |
0.601 |
|
| 2010 |
Mauer J, Chaurasia B, Plum L, Quast T, Hampel B, Blüher M, Kolanus W, Kahn CR, Brüning JC. Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance. Plos Genetics. 6: e1000938. PMID 20463885 DOI: 10.1371/Journal.Pgen.1000938 |
0.56 |
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| 2010 |
Ulanet DB, Ludwig DL, Kahn CR, Hanahan D. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proceedings of the National Academy of Sciences of the United States of America. 107: 10791-8. PMID 20457905 DOI: 10.1073/Pnas.0914076107 |
0.428 |
|
| 2010 |
Rask-Madsen C, Li Q, Freund B, Feather D, Abramov R, Wu IH, Chen K, Yamamoto-Hiraoka J, Goldenbogen J, Sotiropoulos KB, Clermont A, Geraldes P, Dall'Osso C, Wagers AJ, Huang PL, ... ... Kahn CR, et al. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metabolism. 11: 379-89. PMID 20444418 DOI: 10.1016/J.Cmet.2010.03.013 |
0.536 |
|
| 2010 |
Cheng K, Ho K, Stokes R, Scott C, Lau SM, Hawthorne WJ, O'Connell PJ, Loudovaris T, Kay TW, Kulkarni RN, Okada T, Wang XL, Yim SH, Shah Y, Grey ST, ... ... Kahn CR, et al. Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. The Journal of Clinical Investigation. 120: 2171-83. PMID 20440072 DOI: 10.1172/Jci35846 |
0.331 |
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| 2010 |
O'Neill ED, Wilding JP, Kahn CR, Van Remmen H, McArdle A, Jackson MJ, Close GL. Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation. Age (Dordrecht, Netherlands). 32: 209-22. PMID 20431988 DOI: 10.1007/S11357-009-9125-0 |
0.449 |
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| 2010 |
Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh GY, Akazawa H, Shiojima I, Kahn CR, Abel ED, et al. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. The Journal of Clinical Investigation. 120: 1506-14. PMID 20407209 DOI: 10.1172/Jci40096 |
0.51 |
|
| 2010 |
Boucher J, Tseng Y, Kahn CR. Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription. Journal of Biological Chemistry. 285: 17235-17245. PMID 20360006 DOI: 10.1074/Jbc.M110.118620 |
0.555 |
|
| 2010 |
Winnay JN, Boucher J, Mori MA, Ueki K, Kahn CR. A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nature Medicine. 16: 438-45. PMID 20348923 DOI: 10.1038/Nm.2121 |
0.467 |
|
| 2010 |
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, ... ... Kahn CR, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464: 121-5. PMID 20203611 DOI: 10.1038/Nature08778 |
0.679 |
|
| 2010 |
Ueda S, Kitazawa S, Ishida K, Nishikawa Y, Matsui M, Matsumoto H, Aoki T, Nozaki S, Takeda T, Tamori Y, Aiba A, Kahn CR, Kataoka T, Satoh T. Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2254-61. PMID 20203090 DOI: 10.1096/Fj.09-137380 |
0.516 |
|
| 2010 |
Sopasakis VR, Liu P, Suzuki R, Kondo T, Winnay J, Tran TT, Asano T, Smyth G, Sajan MP, Farese RV, Kahn CR, Zhao JJ. Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation. Cell Metabolism. 11: 220-30. PMID 20197055 DOI: 10.1016/J.Cmet.2010.02.002 |
0.577 |
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| 2010 |
Tran TT, Kahn CR. Transplantation of adipose tissue and stem cells: Role in metabolism and disease Nature Reviews Endocrinology. 6: 195-213. PMID 20195269 DOI: 10.1038/Nrendo.2010.20 |
0.317 |
|
| 2010 |
Bouche C, Lopez X, Fleischman A, Cypess AM, O'Shea S, Stefanovski D, Bergman RN, Rogatsky E, Stein DT, Kahn CR, Kulkarni RN, Goldfine AB. Insulin enhances glucose-stimulated insulin secretion in healthy humans. Proceedings of the National Academy of Sciences of the United States of America. 107: 4770-5. PMID 20176932 DOI: 10.1073/Pnas.1000002107 |
0.557 |
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| 2010 |
Yamamoto Y, Gesta S, Lee KY, Tran TT, Saadatirad P, Kahn CR. Adipose depots possess unique developmental gene signatures. Obesity. 18: 872-878. PMID 20111017 DOI: 10.1038/Oby.2009.512 |
0.34 |
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| 2009 |
Ikeda H, Shiojima I, Ozasa Y, Yoshida M, Holzenberger M, Kahn CR, Walsh K, Igarashi T, Abel ED, Komuro I. Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy. Journal of Molecular and Cellular Cardiology. 47: 664-75. PMID 19744489 DOI: 10.1016/J.Yjmcc.2009.08.028 |
0.41 |
|
| 2009 |
Ristow M, Zarse K, Oberbach A, Klöting N, Birringer M, Kiehntopf M, Stumvoll M, Kahn CR, Blüher M. Antioxidants prevent health-promoting effects of physical exercise in humans. Proceedings of the National Academy of Sciences of the United States of America. 106: 8665-8670. PMID 19433800 DOI: 10.1073/Pnas.0903485106 |
0.374 |
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| 2009 |
Wang XL, Suzuki R, Lee K, Tran T, Gunton JE, Saha AK, Patti ME, Goldfine A, Ruderman NB, Gonzalez FJ, Kahn CR. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metabolism. 9: 428-39. PMID 19416713 DOI: 10.1016/J.Cmet.2009.04.001 |
0.414 |
|
| 2009 |
Sajan MP, Standaert ML, Rivas J, Miura A, Kanoh Y, Soto J, Taniguchi CM, Kahn CR, Farese RV. Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFκB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance Diabetologia. 52: 1197-1207. PMID 19357831 DOI: 10.1007/S00125-009-1336-5 |
0.621 |
|
| 2009 |
Escribano O, Guillén C, Nevado C, Gomez-Hernández A, Kahn CR, Benito M. β-cell hyperplasia induced by hepatic insulin resistance: Role of a liver-pancreas endocrine axis through insulin receptor A isoform Diabetes. 58: 820-828. PMID 19136656 DOI: 10.2337/Db08-0551 |
0.545 |
|
| 2009 |
Macotela Y, Boucher J, Tran TT, Kahn CR. Sex and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism Diabetes. 58: 803-812. PMID 19136652 DOI: 10.2337/Db08-1054 |
0.525 |
|
| 2009 |
Princen F, Bard E, Sheikh F, Zhang SS, Wang J, Zago WM, Wu D, Trelles RD, Bailly-Maitre B, Kahn CR, Chen Y, Reed JC, Tong GG, Mercola M, Chen J, et al. Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Molecular and Cellular Biology. 29: 378-88. PMID 19001090 DOI: 10.1128/Mcb.01661-08 |
0.525 |
|
| 2009 |
Patti ME, Brambilla E, Luzi L, Landaker EJ, Kahn CR. Differential regulation of insulin signaling by amino acids Experimental and Clinical Endocrinology & Diabetes. 105: 11-12. DOI: 10.1055/S-0029-1211822 |
0.464 |
|
| 2009 |
Cheatham B, Volchuk A, Kahn CR, Wang L, Rhodes CJ, Klip A. O-13: Functional role of synaptobrevins in insulinstimulated translocation of GLUT4 glucose transporters Experimental and Clinical Endocrinology & Diabetes. 104: 21-22. DOI: 10.1055/S-0029-1211504 |
0.317 |
|
| 2009 |
Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR. Erratum: New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure (Nature (2008) 454 (1000-1004)) Nature. 459. DOI: 10.1038/Nature08038 |
0.511 |
|
| 2008 |
Emanuelli B, Macotela Y, Boucher J, Kahn CR. SOCS-1 deficiency does not prevent diet-induced insulin resistance Biochemical and Biophysical Research Communications. 377: 447-452. PMID 18929539 DOI: 10.1016/J.Bbrc.2008.09.158 |
0.54 |
|
| 2008 |
Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 454: 1000-4. PMID 18719589 DOI: 10.1038/Nature07221 |
0.607 |
|
| 2008 |
Norris AW, Hirshman MF, Yao J, Jessen N, Musi N, Chen L, Sivitz WI, Goodyear LJ, Kahn CR. Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle. Endocrinology. 149: 5374-83. PMID 18653710 DOI: 10.1210/En.2008-0100 |
0.4 |
|
| 2008 |
Biddinger SB, Haas JT, Yu BB, Bezy O, Jing E, Zhang W, Unterman TG, Carey MC, Kahn CR. Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nature Medicine. 14: 778-82. PMID 18587407 DOI: 10.1038/Nm1785 |
0.485 |
|
| 2008 |
Rajala A, Tanito M, Le YZ, Kahn CR, Rajala RV. Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. The Journal of Biological Chemistry. 283: 19781-92. PMID 18480052 DOI: 10.1074/Jbc.M802374200 |
0.407 |
|
| 2008 |
Tran TT, Yamamoto Y, Gesta S, Kahn CR. Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism Cell Metabolism. 7: 410-420. PMID 18460332 DOI: 10.1016/J.Cmet.2008.04.004 |
0.466 |
|
| 2008 |
Koch L, Wunderlich FT, Seibler J, Könner AC, Hampel B, Irlenbusch S, Brabant GE, Kahn CR, Schwenk F, Brüning JC. Central insulin action regulates peripheral glucose and fat metabolism in mice Journal of Clinical Investigation. 118: 2132-2147. PMID 18451994 DOI: 10.1172/Jci31073 |
0.569 |
|
| 2008 |
Tiwari S, Sharma N, Gill PS, Igarashi P, Kahn CR, Wade JB, Ecelbarger CM. Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 105: 6469-74. PMID 18424559 DOI: 10.1073/Pnas.0711283105 |
0.393 |
|
| 2008 |
Emanuelli B, Eberlé D, Suzuki R, Kahn CR. Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance Proceedings of the National Academy of Sciences of the United States of America. 105: 3545-3550. PMID 18296638 DOI: 10.1073/Pnas.0712275105 |
0.564 |
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| 2008 |
Krüger M, Kratchmarova I, Blagoev B, Tseng YH, Kahn CR, Mann M. Dissection of the insulin signaling pathway via quantitative phosphoproteomics. Proceedings of the National Academy of Sciences of the United States of America. 105: 2451-2456. PMID 18268350 DOI: 10.1073/Pnas.0711713105 |
0.433 |
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| 2008 |
Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Alemán JO, Suzuki R, Scapa EF, Agarwal C, Carey MC, Stephanopoulos G, Cohen DE, King GL, Ginsberg HN, Kahn CR. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metabolism. 7: 125-34. PMID 18249172 DOI: 10.1016/J.Cmet.2007.11.013 |
0.5 |
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| 2007 |
Page KA, Dejardin S, Kahn CR, Kulkarni RN, Herold KC, Inzucchi SE. A patient with type B insulin resistance syndrome, responsive to immune therapy. Nature Clinical Practice. Endocrinology & Metabolism. 3: 835-40. PMID 18026162 DOI: 10.1038/Ncpendmet0693 |
0.497 |
|
| 2007 |
Katic M, Kennedy AR, Leykin I, Norris A, McGettrick A, Gesta S, Russell SJ, Bluher M, Maratos-Flier E, Kahn CR. Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice. Aging Cell. 6: 827-39. PMID 18001293 DOI: 10.1111/J.1474-9726.2007.00346.X |
0.502 |
|
| 2007 |
Pospisilik JA, Knauf C, Joza N, Benit P, Orthofer M, Cani PD, Ebersberger I, Nakashima T, Sarao R, Neely G, Esterbauer H, Kozlov A, Kahn CR, Kroemer G, Rustin P, et al. Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell. 131: 476-91. PMID 17981116 DOI: 10.1016/J.Cell.2007.08.047 |
0.57 |
|
| 2007 |
Gesta S, Tseng Y, Kahn CR. Developmental Origin of Fat: Tracking Obesity to Its Source Cell. 131: 242-256. PMID 17956727 DOI: 10.1016/J.Cell.2007.10.004 |
0.301 |
|
| 2007 |
Murata Y, Tsuruzoe K, Kawashima J, Furukawa N, Kondo T, Motoshima H, Igata M, Taketa K, Sasaki K, Kishikawa H, Kahn CR, Toyonaga T, Araki E. IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance. Biochemical and Biophysical Research Communications. 364: 301-7. PMID 17950694 DOI: 10.1016/J.Bbrc.2007.10.007 |
0.553 |
|
| 2007 |
Fink BD, Herlein JA, Almind K, Cinti S, Kahn CR, Sivitz WI. Mitochondrial proton leak in obesity-resistant and obesity-prone mice. American Journal of Physiology-Regulatory Integrative and Comparative Physiology. 293. PMID 17761507 DOI: 10.1152/Ajpregu.00478.2007 |
0.335 |
|
| 2007 |
Jing E, Gesta S, Kahn CR. SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metabolism. 6: 105-14. PMID 17681146 DOI: 10.1016/J.Cmet.2007.07.003 |
0.413 |
|
| 2007 |
Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower WR, Nimal S, Choi CS, Kim S, Shulman GI, Kahn CR, Braun U, Leitges M. Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. The Journal of Clinical Investigation. 117: 2289-301. PMID 17641777 DOI: 10.1172/JCI31408 |
0.431 |
|
| 2007 |
Cohen SE, Kokkotou E, Biddinger SB, Kondo T, Gebhardt R, Kratzsch J, Mantzoros CS, Kahn CR. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. The Journal of Biological Chemistry. 282: 23672-8. PMID 17556363 DOI: 10.1074/Jbc.M704053200 |
0.503 |
|
| 2007 |
Mouche S, Mkaddem SB, Wang W, Katic M, Tseng YH, Carnesecchi S, Steger K, Foti M, Meier CA, Muzzin P, Kahn CR, Ogier-Denis E, Szanto I. Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation. Biochimica Et Biophysica Acta. 1773: 1015-27. PMID 17553579 DOI: 10.1016/J.Bbamcr.2007.03.003 |
0.493 |
|
| 2007 |
Könner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, Brüning JC. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metabolism. 5: 438-49. PMID 17550779 DOI: 10.1016/J.Cmet.2007.05.004 |
0.567 |
|
| 2007 |
Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. The Journal of Biological Chemistry. 282: 23829-40. PMID 17545163 DOI: 10.1074/Jbc.M609680200 |
0.543 |
|
| 2007 |
Kulkarni RN, Kahn CR. Ephs and ephrins keep pancreatic Beta cells connected. Cell. 129: 241-3. PMID 17448984 DOI: 10.1016/J.Cell.2007.04.006 |
0.426 |
|
| 2007 |
Almind K, Manieri M, Sivitz WI, Cinti S, Kahn CR. Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 2366-2371. PMID 17283342 DOI: 10.1073/Pnas.0610416104 |
0.41 |
|
| 2007 |
Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, Kahn CR. The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance. Molecular and Cellular Biology. 27: 2830-40. PMID 17283057 DOI: 10.1128/Mcb.00079-07 |
0.717 |
|
| 2007 |
Laustsen PG, Russell SJ, Cui L, Entingh-Pearsall A, Holzenberger M, Liao R, Kahn CR. Essential Role of Insulin and Insulin-Like Growth Factor 1 Receptor Signaling in Cardiac Development and Function Molecular and Cellular Biology. 27: 1649-1664. PMID 17189427 DOI: 10.1128/Mcb.01110-06 |
0.568 |
|
| 2007 |
Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower WR, Nimal S, Choi CS, Kim S, Shulman GI, Kahn CR, Braun U, Leitges M. Muscle-specific knockout of PKC-λ impairs glucose transport and induces metabolic and diabetic syndromes Journal of Clinical Investigation. 117: 3141-3141. DOI: 10.1172/Jci31408C1 |
0.525 |
|
| 2006 |
Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, Kulkarni RN, Kahn CR, Goodyear LJ. Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3 Molecular and Cellular Biology. 26: 8217-8227. PMID 16966378 DOI: 10.1128/Mcb.00979-06 |
0.51 |
|
| 2006 |
Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, Kahn CR. Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN. Proceedings of the National Academy of Sciences of the United States of America. 103: 12093-7. PMID 16880400 DOI: 10.1073/Pnas.0604628103 |
0.702 |
|
| 2006 |
Biddinger SB, Miyazaki M, Boucher J, Ntambi JM, Kahn CR. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes. 55: 2032-41. PMID 16804073 DOI: 10.2337/Db05-0742 |
0.568 |
|
| 2006 |
Taniguchi CM, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley LC, Kahn CR. Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metabolism. 3: 343-53. PMID 16679292 DOI: 10.1016/J.Cmet.2006.04.005 |
0.72 |
|
| 2006 |
Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM, Peters JL, Shackman JG, Zhang M, Artner I, Satin LS, Stein R, Holzenberger M, Kennedy RT, Kahn CR, et al. Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nature Genetics. 38: 583-8. PMID 16642022 DOI: 10.1038/Ng1787 |
0.468 |
|
| 2006 |
Gesta S, Blüher M, Yamamoto Y, Norris AW, Berndt J, Kralisch S, Boucher J, Lewis C, Kahn CR. Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proceedings of the National Academy of Sciences of the United States of America. 103: 6676-81. PMID 16617105 DOI: 10.1073/Pnas.0601752103 |
0.33 |
|
| 2006 |
Inoue H, Ogawa W, Asakawa A, Okamoto Y, Nishizawa A, Matsumoto M, Teshigawara K, Matsuki Y, Watanabe E, Hiramatsu R, Notohara K, Katayose K, Okamura H, Kahn CR, Noda T, et al. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metabolism. 3: 267-275. PMID 16581004 DOI: 10.1016/J.Cmet.2006.02.009 |
0.515 |
|
| 2006 |
Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Brüning JC. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metabolism. 3: 247-56. PMID 16581002 DOI: 10.1016/J.Cmet.2006.02.010 |
0.536 |
|
| 2006 |
Ilany J, Bilan PJ, Kapur S, Caldwell JS, Patti M, Marette A, Kahn CR. Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level Proceedings of the National Academy of Sciences of the United States of America. 103: 4481-4486. PMID 16537411 DOI: 10.1073/Pnas.0511246103 |
0.524 |
|
| 2006 |
Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nature Reviews. Molecular Cell Biology. 7: 85-96. PMID 16493415 DOI: 10.1038/Nrm1837 |
0.623 |
|
| 2006 |
He Z, Opland DM, Way KJ, Ueki K, Bodyak N, Kang PM, Izumo S, Kulkarni RN, Wang B, Liao R, Kahn CR, King GL. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 787-93. PMID 16469952 DOI: 10.1161/01.Atv.0000209500.15801.4E |
0.427 |
|
| 2006 |
Biddinger SB, Kahn CR. From mice to men: insights into the insulin resistance syndromes. Annual Review of Physiology. 68: 123-58. PMID 16460269 DOI: 10.1146/Annurev.Physiol.68.040104.124723 |
0.556 |
|
| 2006 |
Baumgartl J, Baudler S, Scherner M, Babaev VR, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton MF, Brüning JC. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis (DOI:10.1016/j.cmet.2006.02.010) Cell Metabolism. 3: 469. DOI: 10.1016/J.Cmet.2006.05.008 |
0.484 |
|
| 2005 |
Knauf C, Cani PD, Perrin C, Iglesias MA, Maury JF, Bernard E, Benhamed F, Grémeaux T, Drucker DJ, Kahn CR, Girard J, Tanti JF, Delzenne NM, Postic C, Burcelin R. Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. The Journal of Clinical Investigation. 115: 3554-63. PMID 16322793 DOI: 10.1172/Jci25764 |
0.554 |
|
| 2005 |
Kim YB, Peroni OD, Aschenbach WG, Minokoshi Y, Kotani K, Zisman A, Kahn CR, Goodyear LJ, Kahn BB. Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism. Molecular and Cellular Biology. 25: 9713-23. PMID 16227617 DOI: 10.1128/Mcb.25.21.9713-9723.2005 |
0.432 |
|
| 2005 |
Ueki K, Kadowaki T, Kahn CR. Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome. Hepatology Research : the Official Journal of the Japan Society of Hepatology. 33: 185-92. PMID 16226915 DOI: 10.1016/J.Hepres.2005.09.032 |
0.507 |
|
| 2005 |
Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B. Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess. The Journal of Biological Chemistry. 280: 37489-94. PMID 16166093 DOI: 10.1074/Jbc.M506967200 |
0.553 |
|
| 2005 |
Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, et al. Suppression of aging in mice by the hormone Klotho. Science (New York, N.Y.). 309: 1829-33. PMID 16123266 DOI: 10.1126/Science.1112766 |
0.503 |
|
| 2005 |
Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell. 122: 337-49. PMID 16096055 DOI: 10.1016/J.Cell.2005.05.027 |
0.464 |
|
| 2005 |
Tseng YH, Butte AJ, Kokkotou E, Yechoor VK, Taniguchi CM, Kriauciunas KM, Cypess AM, Niinobe M, Yoshikawa K, Patti ME, Kahn CR. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nature Cell Biology. 7: 601-11. PMID 15895078 DOI: 10.1038/Ncb1259 |
0.704 |
|
| 2005 |
Fisher SJ, Brüning JC, Lannon S, Kahn CR. Insulin Signaling in the Central Nervous System Is Critical for the Normal Sympathoadrenal Response to Hypoglycemia Diabetes. 54: 1447-1451. PMID 15855332 DOI: 10.2337/Diabetes.54.5.1447 |
0.525 |
|
| 2005 |
Biddinger SB, Almind K, Miyazaki M, Kokkotou E, Ntambi JM, Kahn CR. Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes. 54: 1314-23. PMID 15855315 DOI: 10.2337/Diabetes.54.5.1314 |
0.341 |
|
| 2005 |
Katic M, Kahn CR. The role of insulin and IGF-1 signaling in longevity. Cellular and Molecular Life Sciences : Cmls. 62: 320-43. PMID 15723168 DOI: 10.1007/s00018-004-4297-y |
0.378 |
|
| 2005 |
Wijesekara N, Konrad D, Eweida M, Jefferies C, Liadis N, Giacca A, Crackower M, Suzuki A, Mak TW, Kahn CR, Klip A, Woo M. Muscle-specific Pten deletion protects against insulin resistance and diabetes. Molecular and Cellular Biology. 25: 1135-45. PMID 15657439 DOI: 10.1128/Mcb.25.3.1135-1145.2005 |
0.522 |
|
| 2005 |
Ginsberg BH, Kahn CR, Roth J, De Meyts P. Insulin-induced dissociation of its receptor into subunits: possible molecular concomitant of negative cooperativity. Biochemical and Biophysical Research Communications. 73: 1068-74. PMID 15625883 DOI: 10.1016/0006-291X(76)90232-1 |
0.502 |
|
| 2005 |
Ehrenkranz JRL, Lewis NG, Kahn CR, Roth J. Phlorizin: A review Diabetes/Metabolism Research and Reviews. 21: 31-38. PMID 15624123 DOI: 10.1002/Dmrr.532 |
0.334 |
|
| 2005 |
McGettrick AJ, Feener EP, Kahn CR. Human Insulin Receptor Substrate-1 (IRS-1) Polymorphism G972R Causes IRS-1 to Associate with the Insulin Receptor and Inhibit Receptor Autophosphorylation Journal of Biological Chemistry. 280: 6441-6446. PMID 15590636 DOI: 10.1074/Jbc.M412300200 |
0.527 |
|
| 2005 |
Taniguchi CM, Ueki K, Kahn CR. Erratum: Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism (Journal of Clinical Investigation (2005) 115 (718-727) DOI: 10.1172/JCI200523187) Journal of Clinical Investigation. 115. DOI: 10.1172/Jci200523187C1 |
0.583 |
|
| 2005 |
Ueki K, Kondo T, Kahn CR. Erratum: Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms (Molecular and Cellular Biology (2004) 24, 12 (5434-5446)) Molecular and Cellular Biology. 25. DOI: 10.1128/Mcb.25.19.8762.2005 |
0.542 |
|
| 2005 |
Ueki K, Kondo T, Tseng YH, Kahn CR. Erratum: Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse (Proceedings of the National Academy of Sciences of the United States of America (July 13, 2004) 101, 28 (10422-10427)) Proceedings of the National Academy of Sciences of the United States of America. 102. DOI: 10.1073/Pnas.0506917102 |
0.453 |
|
| 2005 |
Brown M, Flier J, Friedman J, Goldstein J, Kahn CR, Lifton R, O'Rahilly S, Spiegelman B. Cell Metabolism: Why, and why now? Cell Metabolism. 1: 3. DOI: 10.1016/J.Cmet.2004.12.007 |
0.332 |
|
| 2004 |
Miura A, Sajan MP, Standaert ML, Bandyopadhyay G, Kahn CR, Farese RV. Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes. Biochemistry. 43: 15503-15509. PMID 15581362 DOI: 10.1021/Bi049221Y |
0.547 |
|
| 2004 |
Almind K, Kahn CR. Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. Diabetes. 53: 3274-3285. PMID 15561960 DOI: 10.2337/Diabetes.53.12.3274 |
0.473 |
|
| 2004 |
Yechoor VK, Patti ME, Ueki K, Laustsen PG, Saccone R, Rauniyar R, Kahn CR. Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice. Proceedings of the National Academy of Sciences of the United States of America. 101: 16525-30. PMID 15546994 DOI: 10.1073/Pnas.0407574101 |
0.483 |
|
| 2004 |
Kahn CR, Roth J. Berson, Yalow, and the JCI: the agony and the ecstasy. Journal of Clinical Investigation. 114: 1051-1054. PMID 15489951 DOI: 10.1172/Jci23316 |
0.51 |
|
| 2004 |
Bouche C, Serdy S, Kahn CR, Goldfine AB. The cellular fate of glucose and its relevance in type 2 diabetes. Endocrine Reviews. 25: 807-830. PMID 15466941 DOI: 10.1210/Er.2003-0026 |
0.452 |
|
| 2004 |
Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. The Journal of Clinical Investigation. 114: 828-36. PMID 15372107 DOI: 10.1172/Jci21845 |
0.511 |
|
| 2004 |
Sajan MP, Standaert ML, Miura A, Kahn CR, Farese RV. Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver, and adipocytes of insulin receptor substrate-1 knockout mice Molecular Endocrinology. 18: 2513-2521. PMID 15256535 DOI: 10.1210/me.2004-0045 |
0.412 |
|
| 2004 |
Entingh-Pearsall A, Kahn CR. Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I. The Journal of Biological Chemistry. 279: 38016-24. PMID 15247278 DOI: 10.1074/jbc.M313201200 |
0.466 |
|
| 2004 |
Ueki K, Kondo T, Tseng YH, Kahn CR. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proceedings of the National Academy of Sciences of the United States of America. 101: 10422-7. PMID 15240880 DOI: 10.1073/Pnas.0402511101 |
0.519 |
|
| 2004 |
Kondo T, Kahn CR. Altered insulin signaling in retinal tissue in diabetic states. Journal of Biological Chemistry. 279: 37997-38006. PMID 15201286 DOI: 10.1074/Jbc.M401339200 |
0.554 |
|
| 2004 |
Ueki K, Kondo T, Kahn CR. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Molecular and Cellular Biology. 24: 5434-46. PMID 15169905 DOI: 10.1128/Mcb.24.12.5434-5446.2004 |
0.581 |
|
| 2004 |
Blüher M, Wilson-Fritch L, Leszyk J, Laustsen PG, Corvera S, Kahn CR. Role of insulin action and cell size on protein expression patterns in adipocytes. The Journal of Biological Chemistry. 279: 31902-9. PMID 15131120 DOI: 10.1074/Jbc.M404570200 |
0.549 |
|
| 2004 |
Blüher M, Patti ME, Gesta S, Kahn BB, Kahn CR. Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression. The Journal of Biological Chemistry. 279: 31891-901. PMID 15131119 DOI: 10.1074/Jbc.M404569200 |
0.503 |
|
| 2004 |
Kondo T, Hafezi-Moghadam A, Thomas K, Wagner DD, Kahn CR. Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier. Biochemical and Biophysical Research Communications. 317: 315-20. PMID 15063759 DOI: 10.1016/J.Bbrc.2004.03.043 |
0.486 |
|
| 2004 |
Nandi A, Kitamura Y, Kahn CR, Accili D. Mouse models of insulin resistance. Physiological Reviews. 84: 623-47. PMID 15044684 DOI: 10.1152/Physrev.00032.2003 |
0.516 |
|
| 2004 |
Goren HJ, Kulkarni RN, Kahn CR. Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. Endocrinology. 145: 3307-3323. PMID 15044376 DOI: 10.1210/En.2003-1400 |
0.54 |
|
| 2004 |
Schubert M, Gautam D, Surjo D, Ueki K, Baudler S, Schubert D, Kondo T, Alber J, Galldiks N, Küstermann E, Arndt S, Jacobs AH, Krone W, Kahn CR, Brüning JC. Role for neuronal insulin resistance in neurodegenerative diseases. Proceedings of the National Academy of Sciences of the United States of America. 101: 3100-5. PMID 14981233 DOI: 10.1073/pnas.0308724101 |
0.392 |
|
| 2004 |
Tseng Y, Kriauciunas KM, Kokkotou E, Kahn CR. Differential roles of insulin receptor substrates in brown adipocyte differentiation Molecular and Cellular Biology. 24: 1918-1929. PMID 14966273 DOI: 10.1128/Mcb.24.5.1918-1929.2004 |
0.543 |
|
| 2004 |
Asilmaz E, Cohen P, Miyazaki M, Dobrzyn P, Ueki K, Fayzikhodjaeva G, Soukas AA, Kahn CR, Ntambi JM, Socci ND, Friedman JM. Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. The Journal of Clinical Investigation. 113: 414-24. PMID 14755338 DOI: 10.1172/Jci19511 |
0.522 |
|
| 2004 |
Cohen SE, Tseng YH, Michael MD, Kahn CR. Effects of insulin-sensitising agents in mice with hepatic insulin resistance. Diabetologia. 47: 407-11. PMID 14730378 DOI: 10.1007/s00125-003-1320-4 |
0.495 |
|
| 2004 |
Kitamura T, Kitamura Y, Nakae J, Giordano A, Cinti S, Kahn CR, Efstratiadis A, Accili D. Mosaic analysis of insulin receptor function. The Journal of Clinical Investigation. 113: 209-19. PMID 14722613 DOI: 10.1172/Jci17810 |
0.562 |
|
| 2004 |
Cariou B, Postic C, Boudou P, Burcelin R, Kahn CR, Girard J, Burnol AF, Mauvais-Jarvis F. Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice. Endocrinology. 145: 1926-32. PMID 14684612 DOI: 10.1210/En.2003-0882 |
0.593 |
|
| 2004 |
Chen D, Mauvais-Jarvis F, Bluher M, Fisher SJ, Jozsi A, Goodyear LJ, Ueki K, Kahn CR. p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Molecular and Cellular Biology. 24: 320-9. PMID 14673165 DOI: 10.1128/Mcb.24.1.320-329.2004 |
0.529 |
|
| 2004 |
Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, Stoffel M, Kahn CR, Polonsky KS. Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. American Journal of Physiology. Endocrinology and Metabolism. 286: E41-9. PMID 14519599 DOI: 10.1152/Ajpendo.00533.2001 |
0.552 |
|
| 2004 |
Schubert M, Gautam D, Surjo D, Ueki K, Baudler S, Schubert D, Alber J, Kahn C, Krone W, Brüning J. The role for neuronal insulin resistance in neurodegenerative diseases Experimental and Clinical Endocrinology & Diabetes. 112. DOI: 10.1055/S-2004-819102 |
0.324 |
|
| 2003 |
Kahn CR. Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes Experimental Diabesity Research. 4: 169-182. PMID 15061645 DOI: 10.1155/Edr.2003.169 |
0.577 |
|
| 2003 |
Goldfine AB, Kahn CR. Adiponectin: linking the fat cell to insulin sensitivity The Lancet. 362: 1431-1432. PMID 14602433 DOI: 10.1016/S0140-6736(03)14727-7 |
0.521 |
|
| 2003 |
Hirashima Y, Tsuruzoe K, Kodama S, Igata M, Toyonaga T, Ueki K, Kahn CR, Araki E. Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway. The Journal of Endocrinology. 179: 253-66. PMID 14596677 DOI: 10.1677/JOE.0.1790253 |
0.458 |
|
| 2003 |
Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Molecular and Cellular Biology. 23: 7222-9. PMID 14517292 DOI: 10.1128/Mcb.23.20.7222-7229.2003 |
0.389 |
|
| 2003 |
Mora A, Davies AM, Bertrand L, Sharif I, Budas GR, Jovanović S, Mouton V, Kahn CR, Lucocq JM, Gray GA, Jovanović A, Alessi DR. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia Embo Journal. 22: 4666-4676. PMID 12970179 DOI: 10.1093/Emboj/Cdg469 |
0.323 |
|
| 2003 |
Norris AW, Chen L, Fisher SJ, Szanto I, Ristow M, Jozsi AC, Hirshman MF, Rosen ED, Goodyear LJ, Gonzalez FJ, Spiegelman BM, Kahn CR. Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. The Journal of Clinical Investigation. 112: 608-18. PMID 12925701 DOI: 10.1172/Jci17305 |
0.55 |
|
| 2003 |
Wolfrum C, Shih DQ, Kuwajima S, Norris AW, Kahn CR, Stoffel M. Role of Foxa-2 in adipocyte metabolism and differentiation. The Journal of Clinical Investigation. 112: 345-56. PMID 12865419 DOI: 10.1172/Jci18698 |
0.454 |
|
| 2003 |
Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, ... Kahn CR, et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proceedings of the National Academy of Sciences of the United States of America. 100: 8466-71. PMID 12832613 DOI: 10.1073/Pnas.1032913100 |
0.504 |
|
| 2003 |
Kahn CR. The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice Transactions of the American Clinical and Climatological Association. 114: 125-148. PMID 12813916 |
0.486 |
|
| 2003 |
Kondo T, Vicent D, Suzuma K, Yanagisawa M, King GL, Holzenberger M, Kahn CR. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. The Journal of Clinical Investigation. 111: 1835-42. PMID 12813019 DOI: 10.1172/JCI17455 |
0.411 |
|
| 2003 |
Entingh AJ, Taniguchi CM, Kahn CR. Bi-directional regulation of brown fat adipogenesis by the insulin receptor. The Journal of Biological Chemistry. 278: 33377-83. PMID 12807888 DOI: 10.1074/Jbc.M303056200 |
0.729 |
|
| 2003 |
Minokoshi Y, Kahn CR, Kahn BB. Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis. The Journal of Biological Chemistry. 278: 33609-12. PMID 12788932 DOI: 10.1074/Jbc.R300019200 |
0.529 |
|
| 2003 |
Jiang ZY, He Z, King BL, Kuroki T, Opland DM, Suzuma K, Suzuma I, Ueki K, Kulkarni RN, Kahn CR, King GL. Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. The Journal of Biological Chemistry. 278: 31964-71. PMID 12775712 DOI: 10.1074/Jbc.M303314200 |
0.462 |
|
| 2003 |
Almind K, Kulkarni RN, Lannon SM, Kahn CR. Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes. 52: 1535-1543. PMID 12765967 DOI: 10.2337/Diabetes.52.6.1535 |
0.502 |
|
| 2003 |
Kulkarni RN, Almind K, Goren HJ, Winnay JN, Ueki K, Okada T, Kahn CR. Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes. 52: 1528-34. PMID 12765966 DOI: 10.2337/Diabetes.52.6.1528 |
0.52 |
|
| 2003 |
Burcelin R, Crivelli V, Perrin C, Da Costa A, Mu J, Kahn BB, Birnbaum MJ, Kahn CR, Vollenweider P, Thorens B. GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization Journal of Clinical Investigation. 111: 1555-1562. PMID 12750405 DOI: 10.1172/Jci16888 |
0.497 |
|
| 2003 |
Lee AV, Zhang P, Ivanova M, Bonnette S, Oesterreich S, Rosen JM, Grimm S, Hovey RC, Vonderhaar BK, Kahn CR, Torres D, George J, Mohsin S, Allred DC, Hadsell DL. Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland. Endocrinology. 144: 2683-94. PMID 12746333 DOI: 10.1210/En.2002-221103 |
0.357 |
|
| 2003 |
Vicent D, Ilany J, Kondo T, Naruse K, Fisher SJ, Kisanuki YY, Bursell S, Yanagisawa M, King GL, Kahn CR. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. The Journal of Clinical Investigation. 111: 1373-80. PMID 12727929 DOI: 10.1172/Jci15211 |
0.518 |
|
| 2003 |
Goldfine AB, Bouche C, Parker RA, Kim C, Kerivan A, Soeldner JS, Martin BC, Warram JH, Kahn CR. Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 2724-9. PMID 12591951 DOI: 10.1073/Pnas.0438009100 |
0.418 |
|
| 2003 |
Fisher SJ, Kahn CR. Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production Journal of Clinical Investigation. 111: 463-468. PMID 12588884 DOI: 10.1172/Jci16426 |
0.577 |
|
| 2003 |
Blüher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (New York, N.Y.). 299: 572-4. PMID 12543978 DOI: 10.1126/Science.1078223 |
0.537 |
|
| 2003 |
Valverde AM, Arribas M, Mur C, Navarro P, Pons S, Cassard-Doulcier A, Kahn CR, Benito M. Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes. Journal of Biological Chemistry. 278: 10221-10231. PMID 12525499 DOI: 10.1074/Jbc.M209363200 |
0.544 |
|
| 2003 |
Kondo T, Vicent D, Suzuma K, Yanagisawa M, King GL, Holzenberger M, Kahn CR. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization Journal of Clinical Investigation. 111: 1835-1842. DOI: 10.1172/Jci200317455 |
0.506 |
|
| 2002 |
Laustsen PG, Michael MD, Crute BE, Cohen SE, Ueki K, Kulkarni RN, Keller SR, Lienhard GE, Kahn CR. Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Genes & Development. 16: 3213-22. PMID 12502742 DOI: 10.1101/Gad.1034802 |
0.521 |
|
| 2002 |
Kitamura T, Kahn CR, Accili D. Insulin receptor knockout mice. Annual Review of Physiology. 65: 313-32. PMID 12471165 DOI: 10.1146/Annurev.Physiol.65.092101.142540 |
0.573 |
|
| 2002 |
Shirakami A, Toyonaga T, Tsuruzoe K, Shirotani T, Matsumoto K, Yoshizato K, Kawashima J, Hirashima Y, Miyamura N, Kahn CR, Araki E. Heterozygous knockout of the IRS-1 gene in mice enhances obesity-linked insulin resistance: a possible model for the development of type 2 diabetes. The Journal of Endocrinology. 174: 309-19. PMID 12176670 DOI: 10.1677/JOE.0.1740309 |
0.407 |
|
| 2002 |
Shiojima I, Yefremashvili M, Luo Z, Kureishi Y, Takahashi A, Tao J, Rosenzweig A, Kahn CR, Abel ED, Walsh K. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. The Journal of Biological Chemistry. 277: 37670-7. PMID 12163490 DOI: 10.1074/Jbc.M204572200 |
0.404 |
|
| 2002 |
Yechoor VK, Patti M, Saccone R, Kahn CR. Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice Proceedings of the National Academy of Sciences of the United States of America. 99: 10587-10592. PMID 12149437 DOI: 10.1073/Pnas.142301999 |
0.464 |
|
| 2002 |
Blüher M, Michael MD, Peroni OD, Ueki K, Carter N, Kahn BB, Kahn CR. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Developmental Cell. 3: 25-38. PMID 12110165 DOI: 10.1016/S1534-5807(02)00199-5 |
0.53 |
|
| 2002 |
Hamer I, Foti M, Emkey R, Cordier-Bussat M, Philippe J, De Meyts P, Maeder C, Kahn CR, Carpentier JL. An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events. Diabetologia. 45: 657-67. PMID 12107746 DOI: 10.1007/s00125-002-0798-5 |
0.435 |
|
| 2002 |
Mauvais-Jarvis F, Kulkarni RN, Kahn CR. Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clinical Endocrinology. 57: 1-9. PMID 12100063 DOI: 10.1046/J.1365-2265.2002.01563.X |
0.505 |
|
| 2002 |
Tseng YH, Ueki K, Kriauciunas KM, Kahn CR. Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin. The Journal of Biological Chemistry. 277: 31601-11. PMID 12082100 DOI: 10.1074/Jbc.M202932200 |
0.544 |
|
| 2002 |
Jost P, Fasshauer M, Kahn CR, Benito M, Meyer M, Ott V, Lowell BB, Klein HH, Klein J. Atypical beta-adrenergic effects on insulin signaling and action in beta(3)-adrenoceptor-deficient brown adipocytes. American Journal of Physiology. Endocrinology and Metabolism. 283: E146-53. PMID 12067855 DOI: 10.1152/Ajpendo.00531.2001 |
0.449 |
|
| 2002 |
Klein J, Fasshauer M, Klein HH, Benito M, Kahn CR. Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 24: 382-8. PMID 11948624 DOI: 10.1002/Bies.10058 |
0.549 |
|
| 2002 |
Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA, Kahn CR. beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nature Genetics. 31: 111-5. PMID 11923875 DOI: 10.1038/Ng872 |
0.458 |
|
| 2002 |
Belke DD, Betuing S, Tuttle MJ, Graveleau C, Young ME, Pham M, Zhang D, Cooksey RC, McClain DA, Litwin SE, Taegtmeyer H, Severson D, Kahn CR, Abel ED. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. The Journal of Clinical Investigation. 109: 629-39. PMID 11877471 DOI: 10.1172/Jci13946 |
0.491 |
|
| 2002 |
Mur C, Valverde AM, Kahn CR, Benito M. Increased Insulin Sensitivity in IGF-I Receptor–Deficient Brown Adipocytes Diabetes. 51: 743-754. PMID 11872675 DOI: 10.2337/Diabetes.51.3.743 |
0.553 |
|
| 2002 |
Almind K, Delahaye L, Hansen T, Obberghen EV, Pedersen O, Kahn CR. Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85α Proceedings of the National Academy of Sciences of the United States of America. 99: 2124-2128. PMID 11842213 DOI: 10.1073/Pnas.042688799 |
0.582 |
|
| 2002 |
Roper MG, Qian WJ, Zhang BB, Kulkarni RN, Kahn CR, Kennedy RT. Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells. Diabetes. 51: S43-9. PMID 11815457 DOI: 10.2337/Diabetes.51.2007.S43 |
0.327 |
|
| 2002 |
Ueki K, Fruman DA, Brachmann SM, Tseng YH, Cantley LC, Kahn CR. Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Molecular and Cellular Biology. 22: 965-77. PMID 11784871 DOI: 10.1128/Mcb.22.3.965-977.2002 |
0.409 |
|
| 2002 |
Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR. Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. The Journal of Clinical Investigation. 109: 141-9. PMID 11781359 DOI: 10.1172/Jci13305 |
0.588 |
|
| 2002 |
Ueki K, Yballe CM, Brachmann SM, Vicent D, Watt JM, Kahn CR, Cantley LC. Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 99: 419-24. PMID 11752399 DOI: 10.1073/Pnas.012581799 |
0.502 |
|
| 2001 |
Dumke CL, Wetter AC, Arias EB, Kahn CR, Cartee GD. Absence of insulin receptor substrate-1 expression does not alter GLUT1 or GLUT4 abundance or contraction-stimulated glucose uptake by mouse skeletal muscle. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Mã©Tabolisme. 33: 696-700. PMID 11753753 DOI: 10.1055/s-2001-19141 |
0.331 |
|
| 2001 |
Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism Nature. 414: 799-806. PMID 11742412 DOI: 10.1038/414799A |
0.577 |
|
| 2001 |
Guerra C, Navarro P, Valverde AM, Arribas M, Brüning J, Kozak LP, Kahn CR, Benito M. Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance. The Journal of Clinical Investigation. 108: 1205-13. PMID 11602628 DOI: 10.1172/JCI13103 |
0.518 |
|
| 2001 |
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 413: 131-8. PMID 11557972 DOI: 10.1038/35093050 |
0.475 |
|
| 2001 |
Leibiger B, Leibiger IB, Moede T, Kemper S, Kulkarni RN, Kahn CR, de Vargas LM, Berggren PO. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Molecular Cell. 7: 559-70. PMID 11463381 DOI: 10.1016/S1097-2765(01)00203-9 |
0.569 |
|
| 2001 |
Kim JK, Zisman A, Fillmore JJ, Peroni OD, Kotani K, Perret P, Zong H, Dong J, Kahn CR, Kahn BB, Shulman GI. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. The Journal of Clinical Investigation. 108: 153-60. PMID 11435467 DOI: 10.1172/Jci10294 |
0.514 |
|
| 2001 |
Flier SN, Kulkarni RN, Kahn CR. Evidence for a circulating islet cell growth factor in insulin-resistant states Proceedings of the National Academy of Sciences of the United States of America. 98: 7475-7480. PMID 11404474 DOI: 10.1073/Pnas.131192998 |
0.531 |
|
| 2001 |
Valverde AM, Mur C, Pons S, Alvarez AM, White MF, Kahn CR, Benito M. Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis. Molecular and Cellular Biology. 21: 2269-80. PMID 11259577 DOI: 10.1128/Mcb.21.7.2269-2280.2001 |
0.466 |
|
| 2001 |
Mauvais-Jarvis F, Kahn CR. Understanding the pathogenesis and treatment of insulin resistance and type 2 diabetes mellitus: what can we learn from transgenic and knockout mice? Diabetes & Metabolism. 26: 433-48. PMID 11173714 |
0.463 |
|
| 2001 |
Fasshauer M, Klein J, Kriauciunas KM, Ueki K, Benito M, Kahn CR. Essential Role of Insulin Receptor Substrate 1 in Differentiation of Brown Adipocytes Molecular and Cellular Biology. 21: 319-329. PMID 11113206 DOI: 10.1128/Mcb.21.1.319-329.2001 |
0.519 |
|
| 2001 |
Tsuruzoe K, Emkey R, Kriauciunas KM, Ueki K, Kahn CR. Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling. Molecular and Cellular Biology. 21: 26-38. PMID 11113178 DOI: 10.1128/Mcb.21.1.26-38.2001 |
0.466 |
|
| 2000 |
Kahn CR, Brüning JC, Michael MD, Kulkarni RN. Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus Journal of Pediatric Endocrinology and Metabolism. 13: 1377-1384. PMID 11202213 DOI: 10.1515/jpem-2000-s611 |
0.477 |
|
| 2000 |
Mauvais-Jarvis F, Virkamaki A, Michael MD, Winnay JN, Zisman A, Kulkarni RN, Kahn CR. A model to explore the interaction between muscle insulin resistance and β-cell dysfunction in the development of type 2 diabetes Diabetes. 49: 2126-2134. PMID 11118016 DOI: 10.2337/Diabetes.49.12.2126 |
0.487 |
|
| 2000 |
Kahn CR, Chen L, Cohen SE. Unraveling the mechanism of action of thiazolidinediones. The Journal of Clinical Investigation. 106: 1305-7. PMID 11104782 DOI: 10.1172/Jci11705 |
0.534 |
|
| 2000 |
Ueki K, Algenstaedt P, Mauvais-Jarvis F, Kahn CR. Positive and Negative Regulation of Phosphoinositide 3-Kinase-Dependent Signaling Pathways by Three Different Gene Products of the p85α Regulatory Subunit Molecular and Cellular Biology. 20: 8035-8046. PMID 11027274 DOI: 10.1128/Mcb.20.21.8035-8046.2000 |
0.409 |
|
| 2000 |
Brüning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Müller-Wieland D, Kahn CR. Role of brain insulin receptor in control of body weight and reproduction. Science (New York, N.Y.). 289: 2122-5. PMID 11000114 DOI: 10.1126/Science.289.5487.2122 |
0.542 |
|
| 2000 |
Hebinck J, Hardt C, Schöls L, Vorgerd M, Briedigkeit L, Kahn CR, Ristow M. Heterozygous expansion of the GAA tract of the X25/frataxin gene is associated with insulin resistance in humans. Diabetes. 49: 1604-7. PMID 10969848 DOI: 10.2337/diabetes.49.9.1604 |
0.371 |
|
| 2000 |
Kriauciunas KM, Myers MG, Kahn CR. Cellular compartmentalization in insulin action: altered signaling by a lipid-modified IRS-1. Molecular and Cellular Biology. 20: 6849-59. PMID 10958681 DOI: 10.1128/Mcb.20.18.6849-6859.2000 |
0.513 |
|
| 2000 |
Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction Molecular Cell. 6: 87-97. PMID 10949030 |
0.488 |
|
| 2000 |
Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JFP, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance Nature Medicine. 6: 924-928. PMID 10932232 DOI: 10.1038/78693 |
0.474 |
|
| 2000 |
Kim JK, Michael MD, Previs SF, Peroni OD, Mauvais-Jarvis F, Neschen S, Kahn BB, Kahn CR, Shulman GI. Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle Journal of Clinical Investigation. 105: 1791-1797. PMID 10862794 DOI: 10.1172/Jci8305 |
0.557 |
|
| 2000 |
Klein J, Fasshauer M, Benito M, Kahn CR. Insulin and the β3-Adrenoceptor Differentially Regulate Uncoupling Protein-1 Expression Molecular Endocrinology. 14: 764-773. PMID 10847579 DOI: 10.1210/Mend.14.6.0477 |
0.49 |
|
| 2000 |
Fasshauer M, Klein J, Ueki K, Kriauciunas KM, Benito M, White MF, Kahn CR. Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes. The Journal of Biological Chemistry. 275: 25494-501. PMID 10829031 DOI: 10.1074/Jbc.M004046200 |
0.583 |
|
| 2000 |
Aspinwall CA, Qian WJ, Roper MG, Kulkarni RN, Kahn CR, Kennedy RT. Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells. The Journal of Biological Chemistry. 275: 22331-8. PMID 10764813 DOI: 10.1074/Jbc.M909647199 |
0.481 |
|
| 2000 |
Winnay JN, Brüning JC, Burks DJ, Kahn CR. Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts Journal of Biological Chemistry. 275: 10545-10550. PMID 10744748 DOI: 10.1074/Jbc.275.14.10545 |
0.503 |
|
| 2000 |
Goldfine AB, Patti M, Zuberi L, Goldstein BJ, LeBlanc R, Landaker EJ, Jiang ZY, Willsky GR, Kahn CR. Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. Metabolism-Clinical and Experimental. 49: 400-410. PMID 10726921 DOI: 10.1016/S0026-0495(00)90418-9 |
0.568 |
|
| 2000 |
Bruning JC, Gillette JA, Zhao Y, Bjorbaeck C, Kotzka J, Knebel B, Avci H, Hanstein B, Lingohr P, Moller DE, Krone W, Kahn CR, Muller-Wieland D. Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene. Proceedings of the National Academy of Sciences of the United States of America. 97: 2462-7. PMID 10716983 DOI: 10.1073/Pnas.97.6.2462 |
0.371 |
|
| 2000 |
Szanto I, Kahn CR. Selective interaction between leptin and insulin signaling pathways in a hepatic cell line. Proceedings of the National Academy of Sciences of the United States of America. 97: 2355-2360. PMID 10688912 DOI: 10.1073/Pnas.050580497 |
0.572 |
|
| 2000 |
Vicent D, Maratos-Flier E, Kahn CR. The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis. Molecular and Cellular Biology. 20: 2158-66. PMID 10688662 DOI: 10.1128/Mcb.20.6.2158-2166.2000 |
0.392 |
|
| 2000 |
Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, DeFronzo RA, Kahn CR, Mandarino LJ. Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle Journal of Clinical Investigation. 105: 311-320. PMID 10675357 DOI: 10.1172/Jci7535 |
0.558 |
|
| 2000 |
Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2 Journal of Clinical Investigation. 105: 199-205. PMID 10642598 DOI: 10.1172/Jci7917 |
0.555 |
|
| 2000 |
Guckelberger O, Imai M, Michael MD, Sévigny J, Kahn CR, Robson SC. IMPAIRED HEPATIC REGENERATION IN LIVER-SPECIFIC INSULIN RECEPTOR KNOCKOUT MICE.: Abstract# 334 Poster Board #-Session: P181-I Transplantation. 69. DOI: 10.1097/00007890-200004271-00334 |
0.458 |
|
| 2000 |
Michael M, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn C. Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction Molecular Cell. 6: 87-97. DOI: 10.1016/S1097-2765(05)00015-8 |
0.573 |
|
| 1999 |
Kahn CR. Insulin signalization and molecular mechanisms of insulin resistance JournéEs Annuelles De DiabéTologie De L'HôTel-Dieu. 125-141. PMID 10732412 |
0.439 |
|
| 1999 |
Inoue G, Cheatham B, Kahn CR. Development of an in vitro reconstitution assay for glucose transporter 4 translocation Proceedings of the National Academy of Sciences of the United States of America. 96: 14919-14924. PMID 10611313 DOI: 10.1073/Pnas.96.26.14919 |
0.461 |
|
| 1999 |
Kulkarni RN, Winnay JN, Daniels M, Brüning JC, Flier SN, Hanahan D, Kahn CR. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. The Journal of Clinical Investigation. 104: R69-75. PMID 10606633 DOI: 10.1172/Jci8339 |
0.551 |
|
| 1999 |
Pete G, Fuller CR, Oldham JM, Smith DR, D'Ercole AJ, Kahn CR, Lund PK. Postnatal growth responses to insulin-like growth factor I in insulin receptor substrate-1-deficient mice. Endocrinology. 140: 5478-87. PMID 10579310 DOI: 10.1210/Endo.140.12.7219 |
0.443 |
|
| 1999 |
Klein J, Fasshauer M, Ito M, Lowell BB, Benito M, Kahn CR. β3-Adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes Journal of Biological Chemistry. 274: 34795-34802. PMID 10574950 DOI: 10.1074/Jbc.274.49.34795 |
0.556 |
|
| 1999 |
Wojtaszewski JFP, Higaki Y, Hirshman MF, Michael MD, Dufresne SD, Kahn CR, Goodyear LJ. Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice Journal of Clinical Investigation. 104: 1257-1264. PMID 10545524 DOI: 10.1172/Jci7961 |
0.532 |
|
| 1999 |
Valverde AM, Kahn CR, Benito M. Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis. Diabetes. 48: 2122-31. PMID 10535444 DOI: 10.2337/diabetes.48.11.2122 |
0.445 |
|
| 1999 |
Gazdag AC, Dumke CL, Kahn CR, Cartee GD. Calorie restriction increases insulin-stimulated glucose transport in skeletal muscle from IRS-1 knockout mice. Diabetes. 48: 1930-6. PMID 10512356 DOI: 10.2337/diabetes.48.10.1930 |
0.42 |
|
| 1999 |
Patti ME, Virkamäki A, Landaker EJ, Kahn CR, Yki-Järvinen H. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Diabetes. 48: 1562-71. PMID 10426374 DOI: 10.2337/DIABETES.48.8.1562 |
0.491 |
|
| 1999 |
Folli F, Saad MJ, Velloso L, Hansen H, Carandente O, Feener EP, Kahn CR. Crosstalk between insulin and angiotensin II signalling systems. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association. 107: 133-9. PMID 10320054 DOI: 10.1055/S-0029-1212088 |
0.473 |
|
| 1999 |
Virkamäki A, Ueki K, Kahn CR. Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance Journal of Clinical Investigation. 103: 931-943. PMID 10194465 DOI: 10.1172/Jci6609 |
0.565 |
|
| 1999 |
Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell. 96: 329-39. PMID 10025399 DOI: 10.1016/S0092-8674(00)80546-2 |
0.537 |
|
| 1999 |
Fruman DA, Snapper SB, Yballe CM, Mauvais-Jarvis F, Kahn CR, Alt FW, Cantley LC. PI 3-KINASE KNOCKOUT MICE: ROLE OF p85α IN B CELL DEVELOPMENT AND PROLIFERATION Biochemical Society Transactions. 27: A73-A73. DOI: 10.1042/Bst027A073C |
0.305 |
|
| 1998 |
Patti M, Kahn CR. The insulin receptor--a critical link in glucose homeostasis and insulin action. Journal of Basic and Clinical Physiology and Pharmacology. 9: 89-110. PMID 10212828 DOI: 10.1515/Jbcpp.1998.9.2-4.89 |
0.578 |
|
| 1998 |
Brüning JC, Michael MD, Winnay JN, Hayashi T, Hörsch D, Accili D, Goodyear LJ, Kahn CR. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance Molecular Cell. 2: 559-569. PMID 9844629 DOI: 10.1016/S1097-2765(00)80155-0 |
0.552 |
|
| 1998 |
Inoue G, Cheatham B, Emkey R, Kahn CR. Dynamics of Insulin Signaling in 3T3-L1 Adipocytes DIFFERENTIAL COMPARTMENTALIZATION AND TRAFFICKING OF INSULIN RECEPTOR SUBSTRATE (IRS)-1 AND IRS-2 Journal of Biological Chemistry. 273: 11548-11555. PMID 9565570 DOI: 10.1074/Jbc.273.19.11548 |
0.54 |
|
| 1998 |
Patti ME, Brambilla E, Luzi L, Landaker EJ, Kahn CR. Bidirectional modulation of insulin action by amino acids. The Journal of Clinical Investigation. 101: 1519-29. PMID 9525995 DOI: 10.1172/JCI1326 |
0.432 |
|
| 1998 |
Kerouz NJ, Hörsch D, Pons S, Kahn CR. Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. The Journal of Clinical Investigation. 100: 3164-72. PMID 9399964 DOI: 10.1172/JCI119872 |
0.473 |
|
| 1997 |
Folli F, Kahn CR, Hansen H, Bouchie JL, Feener EP. Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk. The Journal of Clinical Investigation. 100: 2158-69. PMID 9410892 DOI: 10.1172/JCI119752 |
0.429 |
|
| 1997 |
Emkey R, Kahn CR. Cross-talk between phorbol ester-mediated signaling and tyrosine kinase proto-oncogenes. II. Comparison of phorbol ester and sphingomyelinase-induced phosphorylation of ErbB2 and ErbB3. Journal of Biological Chemistry. 272: 31182-31189. PMID 9388272 DOI: 10.1074/Jbc.272.49.31182 |
0.438 |
|
| 1997 |
Heesom KJ, Harbeck M, Kahn CR, Denton RM. Insulin action on metabolism. Diabetologia. 40: B3-9. PMID 9345638 DOI: 10.1007/BF03168179 |
0.432 |
|
| 1997 |
Silver K, Walston J, Plotnick L, Taylor SI, Kahn CR, Shuldiner AR. Molecular scanning of β-3-adrenergic receptor gene in total congenital lipoatrophic diabetes mellitus Journal of Clinical Endocrinology and Metabolism. 82: 3395-3398. PMID 9329375 DOI: 10.1210/Jcem.82.10.4314 |
0.394 |
|
| 1997 |
Algenstaedt P, Antonetti DA, Yaffe MB, Kahn CR. Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart Journal of Biological Chemistry. 272: 23696-23702. PMID 9295312 DOI: 10.1074/Jbc.272.38.23696 |
0.469 |
|
| 1997 |
Smith-Hall J, Pons S, Patti ME, Burks DJ, Yenush L, Sun XJ, Kahn CR, White MF. The 60 kDA insulin receptor substrate functions like an IRS protein (pp60(IRS3)) in adipose cells Biochemistry. 36: 8304-8310. PMID 9204876 DOI: 10.1021/bi9630974 |
0.416 |
|
| 1997 |
Kim S, Kahn CR. Insulin stimulates p70 S6 kinase in the nucleus of cells. Biochemical and Biophysical Research Communications. 234: 681-685. PMID 9175775 DOI: 10.1006/Bbrc.1997.6699 |
0.485 |
|
| 1997 |
Kim SJ, Kahn CR. Insulin regulation of mitogen-activated protein kinase kinase (MEK), mitogen-activated protein kinase and casein kinase in the cell nucleus: a possible role in the regulation of gene expression. The Biochemical Journal. 621-7. PMID 9169593 DOI: 10.1042/BJ3230621 |
0.371 |
|
| 1997 |
Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles Cell. 88: 561-572. PMID 9038347 DOI: 10.1016/S0092-8674(00)81896-6 |
0.57 |
|
| 1997 |
Brüning JC, Winnay J, Cheatham B, Kahn CR. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Molecular and Cellular Biology. 17: 1513-21. PMID 9032279 DOI: 10.1128/Mcb.17.3.1513 |
0.375 |
|
| 1997 |
Folli F, Saad MJ, Kahn CR. Insulin receptor/IRS-1/PI 3-kinase signaling system in corticosteroid-induced insulin resistance. Acta Diabetologica. 33: 185-92. PMID 8904923 DOI: 10.1007/BF02048541 |
0.461 |
|
| 1996 |
Patti M, Kahn CR. Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus Trends in Endocrinology and Metabolism. 7: 311-319. PMID 18406764 DOI: 10.1016/S1043-2760(96)00154-3 |
0.54 |
|
| 1996 |
Cheatham B, Volchuk A, Kahn CR, Wang L, Rhodes CJ, Klip A. Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins Proceedings of the National Academy of Sciences of the United States of America. 93: 15169-15173. PMID 8986782 DOI: 10.1073/Pnas.93.26.15169 |
0.506 |
|
| 1996 |
Folli F, Ghidella S, Bonfanti L, Kahn CR, Merighi A. The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system Molecular Neurobiology. 13: 155-183. PMID 8938649 DOI: 10.1007/Bf02740639 |
0.491 |
|
| 1996 |
Inoue G, Cheatham B, Kahn CR. Different pathways of postreceptor desensitization following chronic insulin treatment and in cells overexpressing constitutively active insulin receptors. The Journal of Biological Chemistry. 271: 28206-11. PMID 8910437 DOI: 10.1074/jbc.271.45.28206 |
0.429 |
|
| 1996 |
Velloso LA, Folli F, Sun XJ, White MF, Saad MJ, Kahn CR. Cross-talk between the insulin and angiotensin signaling systems. Proceedings of the National Academy of Sciences of the United States of America. 93: 12490-5. PMID 8901609 DOI: 10.1073/Pnas.93.22.12490 |
0.4 |
|
| 1996 |
Moyers JS, Bilan PJ, Reynet C, Kahn CR. Overexpression of Rad Inhibits Glucose Uptake in Cultured Muscle and Fat Cells Journal of Biological Chemistry. 271: 23111-23116. PMID 8798502 DOI: 10.1074/Jbc.271.38.23111 |
0.502 |
|
| 1996 |
Ura S, Araki E, Kishikawa H, Shirotani T, Todaka M, Isami S, Shimoda S, Yoshimura R, Matsuda K, Motoyoshi S, Miyamura N, Kahn CR, Shichiri M. Molecular scanning of the insulin receptor substrate-1 (IRS-1) gene in Japanese patients with NIDDM: identification of five novel polymorphisms. Diabetologia. 39: 600-8. PMID 8739921 DOI: 10.1007/BF00403308 |
0.35 |
|
| 1996 |
Kahn CR, Vicent D, Doria A. Genetics of non-insulin-dependent (type-II) diabetes mellitus. Annual Review of Medicine. 47: 509-31. PMID 8712800 DOI: 10.1146/annurev.med.47.1.509 |
0.441 |
|
| 1996 |
Almind K, Inoue G, Pedersen O, Kahn CR. A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies. The Journal of Clinical Investigation. 97: 2569-75. PMID 8647950 DOI: 10.1172/JCI118705 |
0.486 |
|
| 1996 |
Reynet C, Kahn CR, Loeken MR. Expression of the gene encoding glycogen phosphorylase is elevated in diabetic rat skeletal muscle and is regulated by insulin and cyclic AMP. Diabetologia. 39: 183-9. PMID 8635670 DOI: 10.1007/BF00403961 |
0.394 |
|
| 1996 |
Antonetti DA, Algenstaedt P, Kahn CR. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain Molecular and Cellular Biology. 16: 2195-2203. PMID 8628286 |
0.308 |
|
| 1996 |
Araki E, Haag BL, Matsuda K, Shichiri M, Kahn CR. Characterization and regulation of the mouse insulin receptor substrate gene promoter. Molecular Endocrinology (Baltimore, Md.). 9: 1367-79. PMID 8544845 DOI: 10.1210/MEND.9.10.8544845 |
0.375 |
|
| 1996 |
Ura S, Araki E, Kishikawa H, Shirotani T, Todaka M, Isami S, Shimoda S, Yoshimura R, Matsuda K, Motoyoshi S, Miyamura N, Kahn CR, Shichiri M. Molecular scanning of the insulin receptor substrate-1 (IRS-1) gene in Japanese patients with NIDDM: identification of five novel polymorphisms Diabetologia. 39: 600-608. DOI: 10.1007/S001250050484 |
0.353 |
|
| 1995 |
Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CR. In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus Molecular and Cellular Biochemistry. 153: 217-231. PMID 8927042 DOI: 10.1007/Bf01075941 |
0.55 |
|
| 1995 |
Araki E, Kahn CR, Shichiri M. [Characterization of the IRS-1 (insulin receptor substrate-1) gene and its promoter]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 52: 2659-64. PMID 7983795 |
0.417 |
|
| 1995 |
Saad MJ, Folli F, Kahn CR. Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells. Endocrinology. 136: 1579-88. PMID 7895667 DOI: 10.1210/ENDO.136.4.7895667 |
0.483 |
|
| 1995 |
Rothman DL, Magnusson I, Cline G, Gerard D, Kahn CR, Shulman RG, Shulman GI. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proceedings of the National Academy of Sciences of the United States of America. 92: 983-7. PMID 7862678 DOI: 10.1073/Pnas.92.4.983 |
0.369 |
|
| 1995 |
Yamada K, Carpentier JL, Cheatham B, Goncalves E, Shoelson SE, Kahn CR. Role of the transmembrane domain and flanking amino acids in internalization and down-regulation of the insulin receptor. The Journal of Biological Chemistry. 270: 3115-22. PMID 7852393 DOI: 10.1074/Jbc.270.7.3115 |
0.457 |
|
| 1995 |
Yamada K, Goncalves E, Carpentier JL, Kahn CR, Shoelson SE. Transmembrane domain inversion blocks ER release and insulin receptor signaling. Biochemistry. 34: 946-54. PMID 7827053 DOI: 10.1021/Bi00003A029 |
0.477 |
|
| 1995 |
Cheatham B, Kahn CR. Insulin action and the insulin signaling network. Endocrine Reviews. 16: 117-42. PMID 7781591 DOI: 10.1210/EDRV-16-2-117 |
0.432 |
|
| 1995 |
Magré J, Goldfine AB, Warram JH, Krolewski AS, Kahn CR. Analysis of the insulin receptor gene in noninsulin-dependent diabetes mellitus by denaturing gradient gel blots: a clinical research center study. The Journal of Clinical Endocrinology and Metabolism. 80: 1882-7. PMID 7775636 DOI: 10.1210/JCEM.80.6.7775636 |
0.336 |
|
| 1995 |
Renard E, Grigorescu F, Lavabre C, Kahn CR. Insulin-dependent phosphatidylinositol 3'-kinase activity co-precipitates with insulin receptor in human circulating mononuclear cells. Biochemical and Biophysical Research Communications. 209: 234-41. PMID 7726840 DOI: 10.1006/Bbrc.1995.1494 |
0.457 |
|
| 1995 |
Goldfine AB, Kahn CR. Insulin allergy and insulin resistance. Current Therapy in Endocrinology and Metabolism. 5: 461-4. PMID 7704774 |
0.443 |
|
| 1995 |
Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CR. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. The Journal of Clinical Endocrinology and Metabolism. 80: 3311-20. PMID 7593444 DOI: 10.1210/JCEM.80.11.7593444 |
0.416 |
|
| 1995 |
Patti ME, Sun XJ, Bruening JC, Araki E, Lipes MA, White MF, Kahn CR. 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. The Journal of Biological Chemistry. 270: 24670-3. PMID 7559579 DOI: 10.1074/Jbc.270.42.24670 |
0.545 |
|
| 1995 |
Myers MG, Cheatham B, Fisher TL, Jachna BR, Kahn CR, Backer JM, White MF. Common and distinct elements in insulin and PDGF signaling. Annals of the New York Academy of Sciences. 766: 369-87. PMID 7486683 DOI: 10.1111/J.1749-6632.1995.Tb26687.X |
0.506 |
|
| 1995 |
Kahn CR. Molecular biology of diabetes. I. Autoimmunity and genetics; Insulin synthesis and secretion: Edited by Boris Draznin and Derek LeRoith. Totowa, NJ, Humana Press, 1994, $89.50 (xiii + 404 pages), ISBN 0-896-03286-8 Trends in Endocrinology and Metabolism. 6: 254-255. DOI: 10.1016/1043-2760(95)90044-6 |
0.44 |
|
| 1994 |
White MF, Kahn CR. The insulin signaling system Journal of Biological Chemistry. 269: 1-4. PMID 8276779 |
0.427 |
|
| 1994 |
Edge AS, Karasik A, Yamada K, Kahn CR. Effect of dexamethasone on the carbohydrate chains of the insulin receptor. Biochemical and Biophysical Research Communications. 200: 852-9. PMID 8179619 DOI: 10.1006/Bbrc.1994.1529 |
0.379 |
|
| 1994 |
Araki E, Haag BL, Kahn CR. Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1 Biochimica Et Biophysica Acta. 1221: 353-356. PMID 8167159 DOI: 10.1016/0167-4889(94)90261-5 |
0.404 |
|
| 1994 |
Wilden PA, Kahn CR. The level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase, microtubule-associated protein, and S6 kinases. Molecular Endocrinology (Baltimore, Md.). 8: 558-67. PMID 8058065 DOI: 10.1210/MEND.8.5.8058065 |
0.384 |
|
| 1994 |
Kahn CR. Banting lecture: Insulin action, diabetogenes, and the cause of type II diabetes Diabetes. 43: 1066-1084. PMID 8039601 |
0.382 |
|
| 1994 |
Alarcón C, Cheatham B, Lincoln B, Kahn CR, Siddle K, Rhodes CJ. A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor. The Biochemical Journal. 257-65. PMID 8037679 DOI: 10.1042/BJ3010257 |
0.372 |
|
| 1994 |
Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Molecular and Cellular Biology. 14: 4902-11. PMID 8007986 DOI: 10.1128/Mcb.14.7.4902 |
0.365 |
|
| 1994 |
Ferber S, Meyerovitch J, Kriauciunas KM, Kahn CR. Vanadate normalizes hyperglycemia and phosphoenolpyruvate carboxykinase mRNA levels in ob/ob mice. Metabolism: Clinical and Experimental. 43: 1346-54. PMID 7968588 DOI: 10.1016/0026-0495(94)90026-4 |
0.402 |
|
| 1994 |
Folli F, Bonfanti L, Renard E, Kahn CR, Merighi A. Insulin receptor substrate-1 (IRS-1) distribution in the rat central nervous system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 6412-22. PMID 7965046 DOI: 10.1523/JNEUROSCI.14-11-06412.1994 |
0.36 |
|
| 1994 |
Folli F, Bonfanti L, Renard E, Kahn CR, Merighi A. Insulin receptor substrate-1 (IRS-1) distribution in the rat central nervous system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 6412-22. PMID 7965046 DOI: 10.1523/JNEUROSCI.14-11-06412.1994 |
0.36 |
|
| 1994 |
Chuang LM, Hausdorff SF, Myers MG, White MF, Birnbaum MJ, Kahn CR. Interactive roles of ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes Journal of Biological Chemistry. 269: 27645-27649. PMID 7961682 |
0.424 |
|
| 1994 |
Ouwens DM, van der Zon GC, Pronk GJ, Bos JL, Möller W, Cheatham B, Kahn CR, Maassen JA. A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation. The Journal of Biological Chemistry. 269: 33116-22. PMID 7806540 |
0.403 |
|
| 1994 |
Araki E, Lipes MA, Patti ME, Brüning JC, Haag B, Johnson RS, Kahn CR. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene Nature. 372: 186-190. PMID 7526222 DOI: 10.1038/372186A0 |
0.567 |
|
| 1994 |
Saad MJA, Folli F, Araki E, Hashimoto N, Csermely P, Kahn CR. Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes : effects of differentiation, insulin, and dexamethasone Molecular Endocrinology. 8: 545-557. PMID 7520127 DOI: 10.1210/Mend.8.5.7520127 |
0.436 |
|
| 1994 |
Kim SJ, Kahn CR. Insulin stimulates phosphorylation of c-Jun, c-Fos, and Fos-related proteins in cultured adipocytes. The Journal of Biological Chemistry. 269: 11887-92. PMID 7512956 |
0.334 |
|
| 1994 |
Kahn CR, Folli F. Molecular determinants of insulin action. Hormone Research. 93-101. PMID 7505252 DOI: 10.1159/000182793 |
0.469 |
|
| 1994 |
Chuang LM, Hausdorff SF, Myers MG, White MF, Birnbaum MJ, Kahn CR. Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes. Journal of Biological Chemistry. 269: 27645-27649. DOI: 10.1016/s0021-9258(18)47034-2 |
0.415 |
|
| 1994 |
White M, Kahn C. The insulin signaling system. Journal of Biological Chemistry. 269: 1-4. DOI: 10.1016/s0021-9258(17)42297-6 |
0.427 |
|
| 1993 |
Kahn CR, Goldfine AB. Molecular determinants of insulin action Journal of Diabetes and Its Complications. 7: 92-105. PMID 8518461 DOI: 10.1016/1056-8727(93)90034-V |
0.573 |
|
| 1993 |
Araki E, Sun XJ, Haag BL, Chuang LM, Zhang Y, Yang-Feng TL, White MF, Kahn CR. Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization. Diabetes. 42: 1041-54. PMID 8513971 DOI: 10.2337/diab.42.7.1041 |
0.359 |
|
| 1993 |
Feener EP, Backer JM, King GL, Wilden PA, Sun XJ, Kahn CR, White MF. Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor Journal of Biological Chemistry. 268: 11256-11264. PMID 8496180 |
0.418 |
|
| 1993 |
Chuang LM, Myers MG, Backer JM, Shoelson SE, White MF, Birnbaum MJ, Kahn CR. Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase. Molecular and Cellular Biology. 13: 6653-60. PMID 8413261 DOI: 10.1128/Mcb.13.11.6653 |
0.367 |
|
| 1993 |
Goncalves E, Yamada K, Thatte HS, Backer JM, Golan DE, Kahn CR, Shoelson SE. Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility. Proceedings of the National Academy of Sciences of the United States of America. 90: 5762-6. PMID 8390680 DOI: 10.1073/Pnas.90.12.5762 |
0.346 |
|
| 1993 |
Kriauciunas KM, Goldstein BJ, Lipes MA, Kahn CR. Modulation of expression of insulin and IGF-I receptor by Epstein-Barr virus and its gene products LMP and EBNA-2 in lymphocyte cell lines. Journal of Cellular Physiology. 154: 486-95. PMID 8382208 DOI: 10.1002/JCP.1041540306 |
0.406 |
|
| 1993 |
Carpentier JL, Paccaud JP, Backer J, Gilbert A, Orci L, Kahn CR, Baecker J [corrected to Backer J]. Two steps of insulin receptor internalization depend on different domains of the beta-subunit. The Journal of Cell Biology. 122: 1243-52. PMID 8376461 DOI: 10.1083/JCB.122.6.1243 |
0.316 |
|
| 1993 |
Kim SJ, Kahn CR. Insulin induces rapid accumulation of insulin receptors and increases tyrosine kinase activity in the nucleus of cultured adipocytes. Journal of Cellular Physiology. 157: 217-28. PMID 8227156 DOI: 10.1002/JCP.1041570203 |
0.486 |
|
| 1993 |
Saad MJ, Folli F, Kahn JA, Kahn CR. Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats. The Journal of Clinical Investigation. 92: 2065-72. PMID 7691892 DOI: 10.1172/JCI116803 |
0.444 |
|
| 1993 |
Cheatham B, Shoelson SE, Yamada K, Goncalves E, Kahn CR. Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1. Proceedings of the National Academy of Sciences of the United States of America. 90: 7336-40. PMID 7688476 DOI: 10.1073/Pnas.90.15.7336 |
0.448 |
|
| 1993 |
Chuang LM, Myers MG, Seidner GA, Birnbaum MJ, White MF, Kahn CR. Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 90: 5172-5. PMID 7685118 DOI: 10.1073/Pnas.90.11.5172 |
0.482 |
|
| 1993 |
Csermely P, Schnaider T, Cheatham B, Olson MO, Kahn CR. Insulin induces the phosphorylation of nucleolin. A possible mechanism of insulin-induced RNA efflux from nuclei. The Journal of Biological Chemistry. 268: 9747-52. PMID 7683660 |
0.44 |
|
| 1993 |
Kahn CR, White MF, Shoelson SE, Backer JM, Araki E, Cheatham B, Csermely P, Folli F, Goldstein BJ, Huertas P. The insulin receptor and its substrate: molecular determinants of early events in insulin action. Recent Progress in Hormone Research. 48: 291-339. PMID 7680139 DOI: 10.1016/B978-0-12-571148-7.50015-4 |
0.552 |
|
| 1993 |
Kahn CR, Saad MJ. Alterations in insulin receptor and substrate phosphorylation in hypertensive rats. Journal of the American Society of Nephrology : Jasn. 3: S69-77. PMID 1457763 DOI: 10.1681/ASN.V34s69 |
0.474 |
|
| 1993 |
Csermely P, Schnaider T, Cheatham B, Olson M, Kahn C. Insulin induces the phosphorylation of nucleolin. A possible mechanism of insulin-induced RNA efflux from nuclei Journal of Biological Chemistry. 268: 9747-9752. DOI: 10.1016/s0021-9258(18)98411-5 |
0.414 |
|
| 1993 |
Feener E, Backer J, King G, Wilden P, Sun X, Kahn C, White M. Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor Journal of Biological Chemistry. 268: 11256-11264. DOI: 10.1016/s0021-9258(18)82118-4 |
0.449 |
|
| 1992 |
Hauguel-DeMouzon S, Csermely P, Zoppini G, Kahn CR. Quantitative dissociation between EGF effects on c-myc and c-fos gene expression, DNA synthesis, and epidermal growth factor receptor tyrosine kinase activity. Journal of Cellular Physiology. 150: 180-7. PMID 1730782 DOI: 10.1002/Jcp.1041500124 |
0.31 |
|
| 1992 |
Müller-Wieland D, White MF, Behnke B, Gebhardt A, Neumann S, Krone W, Kahn CR. Pertussis toxin inhibits autophosphorylation and activation of the insulin receptor kinase. Biochemical and Biophysical Research Communications. 181: 1479-85. PMID 1722405 DOI: 10.1016/0006-291X(91)92106-T |
0.56 |
|
| 1992 |
Goldstein BJ, Zhang WR, Hashimoto N, Kahn CR. Approaches to the molecular cloning of protein-tyrosine phosphatases in insulin-sensitive tissues. Molecular and Cellular Biochemistry. 109: 107-13. PMID 1625676 DOI: 10.1007/BF00229763 |
0.472 |
|
| 1992 |
Cheatham B, Kahn CR. Cysteine 647 in the insulin receptor is required for normal covalent interaction between alpha- and beta-subunits and signal transduction. The Journal of Biological Chemistry. 267: 7108-15. PMID 1551916 |
0.344 |
|
| 1992 |
Meyerovitch J, Backer JM, Csermely P, Shoelson SE, Kahn CR. Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells. Biochemistry. 31: 10338-44. PMID 1420153 DOI: 10.1021/Bi00157A023 |
0.368 |
|
| 1992 |
Csermely P, Kahn CR. Insulin induces the phosphorylation of DNA-binding nuclear proteins including lamins in 3T3-F442A. Biochemistry. 31: 9940-6. PMID 1390777 DOI: 10.1021/BI00156A012 |
0.41 |
|
| 1992 |
Sun XJ, Miralpeix M, Myers MG, Glasheen EM, Backer JM, Kahn CR, White MF. Expression and function of IRS-1 in insulin signal transmission Journal of Biological Chemistry. 267: 22662-22672. PMID 1385403 |
0.476 |
|
| 1992 |
Folli F, Saad MJA, Backer JM, Kahn CR. Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat Journal of Biological Chemistry. 267: 22171-22177. PMID 1385396 |
0.372 |
|
| 1992 |
Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet (London, England). 340: 925-9. PMID 1357346 DOI: 10.1016/0140-6736(92)92814-V |
0.408 |
|
| 1992 |
Yamada K, Goncalves E, Kahn CR, Shoelson SE. Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro. The Journal of Biological Chemistry. 267: 12452-61. PMID 1352286 |
0.432 |
|
| 1992 |
Saad MJ, Araki E, Miralpeix M, Rothenberg PL, White MF, Kahn CR. Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. The Journal of Clinical Investigation. 90: 1839-49. PMID 1331176 DOI: 10.1172/Jci116060 |
0.479 |
|
| 1992 |
Wilden PA, Kahn CR, Siddle K, White MF. Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function Journal of Biological Chemistry. 267: 16660-16668. PMID 1322912 |
0.397 |
|
| 1992 |
Wilden PA, Siddle K, Haring E, Backer JM, White MF, Kahn CR. The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities: Analysis with insulin and anti-receptor antibodies Journal of Biological Chemistry. 267: 13719-13727. PMID 1320027 |
0.41 |
|
| 1992 |
Zoppini G, Kahn CR. Effect of phospholipase treatment on insulin receptor signal transduction. Diabetologia. 35: 109-15. PMID 1312492 DOI: 10.1007/BF00402541 |
0.436 |
|
| 1992 |
Backer JM, Schroeder GG, Kahn CR, Myers MG, Wilden PA, Cahill DA, White MF. Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation Journal of Biological Chemistry. 267: 1367-1374. PMID 1309768 |
0.412 |
|
| 1992 |
Backer JM, Schroeder GG, Kahn CR, Myers MG, Wilden PA, Cahill DA, White MF. Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation. Journal of Biological Chemistry. 267: 1367-1374. DOI: 10.1016/s0021-9258(18)48440-2 |
0.408 |
|
| 1992 |
Yamada K, Goncalves E, Kahn C, Shoelson S. Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro. Journal of Biological Chemistry. 267: 12452-12461. DOI: 10.1016/s0021-9258(18)42298-3 |
0.378 |
|
| 1992 |
Wilden P, Siddle K, Haring E, Backer J, White M, Kahn C. The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies. Journal of Biological Chemistry. 267: 13719-13727. DOI: 10.1016/s0021-9258(18)42273-9 |
0.381 |
|
| 1992 |
Wilden P, Kahn C, Siddle K, White M. Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function. Journal of Biological Chemistry. 267: 16660-16668. DOI: 10.1016/S0021-9258(18)42053-4 |
0.349 |
|
| 1992 |
Sun X, Miralpeix M, Myers MG, Glasheen E, Backer J, Kahn C, White M. Expression and function of IRS-1 in insulin signal transmission. Journal of Biological Chemistry. 267: 22662-22672. DOI: 10.1016/s0021-9258(18)41723-1 |
0.402 |
|
| 1992 |
Folli F, Saad M, Backer J, Kahn C. Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat. Journal of Biological Chemistry. 267: 22171-22177. DOI: 10.1016/s0021-9258(18)41650-x |
0.425 |
|
| 1991 |
Rothenberg PL, Lane WS, Karasik A, Backer J, White M, Kahn CR. Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase. The Journal of Biological Chemistry. 266: 8302-11. PMID 2022647 |
0.449 |
|
| 1991 |
Ferber S, Gross DJ, Villa-Komaroff L, Danehy F, Vollenweider F, Meyer K, Loeken MR, Kahn CR, Halban PA. Heterogeneity of expression and secretion of native and mutant [AspB10]insulin in AtT20 cells. Molecular Endocrinology (Baltimore, Md.). 5: 319-26. PMID 1890988 DOI: 10.1210/Mend-5-3-319 |
0.495 |
|
| 1991 |
Pedersen O, Kahn CR, Flier JS, Kahn BB. High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats. Endocrinology. 129: 771-777. PMID 1855475 DOI: 10.1210/Endo-129-2-771 |
0.429 |
|
| 1991 |
Okamoto M, Karasik A, White MF, Kahn CR. Coordinate phosphorylation of insulin-receptor kinase and its 175,000-Mr endogenous substrate in rat hepatocytes Diabetes. 40: 66-72. PMID 1849850 DOI: 10.2337/Diab.40.1.66 |
0.449 |
|
| 1991 |
Mouzon SH, Kahn CR. Insulin-Like Growth Factor-Mediated Phosphorylation and Protooncogene Induction in Madin-Darby Canine Kidney Cells Molecular Endocrinology. 5: 51-60. PMID 1708099 DOI: 10.1210/Mend-5-1-51 |
0.497 |
|
| 1991 |
Meyerovitch J, Rothenberg P, Shechter Y, Bonner-Weir S, Kahn CR. Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus Journal of Clinical Investigation. 87: 1286-1294. PMID 1707061 DOI: 10.1172/Jci115131 |
0.43 |
|
| 1991 |
Shoelson SE, Boni-Schnetzler M, Pilch PF, Kahn CR. Autophosphorylation within insulin receptor beta-subunits can occur as an intramolecular process. Biochemistry. 30: 7740-6. PMID 1651107 DOI: 10.1021/bi00245a010 |
0.321 |
|
| 1991 |
Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, White MF. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein Nature. 352: 73-76. PMID 1648180 DOI: 10.1038/352073A0 |
0.553 |
|
| 1991 |
Rothenberg P, Lane W, Karasik A, Backer J, White M, Kahn C. Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase Journal of Biological Chemistry. 266: 8302-8311. DOI: 10.1016/s0021-9258(18)92976-5 |
0.365 |
|
| 1990 |
Karasik A, Rothenberg PL, Yamada K, White MF, Kahn CR. Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats. The Journal of Biological Chemistry. 265: 10226-31. PMID 2354998 |
0.359 |
|
| 1990 |
Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR. Slow Glucose Removal Rate and Hyperinsulinemia Precede the Development of Type II Diabetes in the Offspring of Diabetic Parents Annals of Internal Medicine. 113: 909-915. PMID 2240915 DOI: 10.7326/0003-4819-113-12-909 |
0.444 |
|
| 1990 |
Backer JM, Kahn CR, Cahill DA, Ullrich A, White MF. Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor β-subunit Journal of Biological Chemistry. 265: 16450-16454. PMID 2204623 |
0.442 |
|
| 1990 |
Backer JM, Kahn CR, White MF. The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells Journal of Biological Chemistry. 265: 14828-14835. PMID 2203763 |
0.462 |
|
| 1990 |
Wilden PA, Backer JM, Kahn CR, Cahill DA, Schroeder GJ, White MF. The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth Proceedings of the National Academy of Sciences of the United States of America. 87: 3358-3362. PMID 2159147 DOI: 10.1073/Pnas.87.9.3358 |
0.493 |
|
| 1990 |
Kruszynska YT, Halban PA, Kahn CR, White MF. Activation of liver and muscle insulin receptor tyrosine kinase activity during in vivo insulin administration in rats Diabetologia. 33: 77-83. PMID 2158467 DOI: 10.1007/Bf00401044 |
0.453 |
|
| 1990 |
Edge AS, Kahn CR, Spiro RG. Insulin receptor carbohydrate units contain poly-N-acetyllactosamine chains. Endocrinology. 127: 1887-95. PMID 2119296 DOI: 10.1210/Endo-127-4-1887 |
0.418 |
|
| 1990 |
Kahn C. SESSION 1: “Molecular Mechanisms and Therapeutic Approaches to Insulin Resistance” Fundamental & Clinical Pharmacology. 4: 5s-10s. DOI: 10.1111/j.1472-8206.1990.tb00054.x |
0.387 |
|
| 1990 |
Karasik A, Rothenberg PL, Yamada K, White MF, Kahn CR. Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats. Journal of Biological Chemistry. 265: 10226-10231. DOI: 10.1016/s0021-9258(18)86935-6 |
0.35 |
|
| 1990 |
Backer J, Kahn C, White M. The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells. Journal of Biological Chemistry. 265: 14828-14835. DOI: 10.1016/s0021-9258(18)77189-5 |
0.362 |
|
| 1990 |
Backer JM, Kahn CR, Cahill DA, Ullrich A, White MF. Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit. Journal of Biological Chemistry. 265: 16450-16454. DOI: 10.1016/s0021-9258(17)46243-0 |
0.372 |
|
| 1989 |
Kwok CF, Goldstein BJ, Muller-Wieland D, Lee TS, Kahn CR, King GL. Identification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats. Journal of Clinical Investigation. 83: 127-136. PMID 2910904 DOI: 10.1172/Jci113848 |
0.419 |
|
| 1989 |
Reddy SS, Kahn CR. Insulin resistance: a look at the role of insulin receptor kinase. Diabetic Medicine : a Journal of the British Diabetic Association. 5: 621-9. PMID 2851405 DOI: 10.1111/j.1464-5491.1988.tb01069.x |
0.462 |
|
| 1989 |
Goldstein BJ, Kahn CR. Insulin receptor messenger ribonucleic acid sequence alterations detected by ribonuclease cleavage in patients with syndromes of insulin resistance. The Journal of Clinical Endocrinology and Metabolism. 69: 15-24. PMID 2732294 DOI: 10.1210/Jcem-69-1-15 |
0.487 |
|
| 1989 |
White MF, Kahn CR. Cascade of autophosphorylation in the beta-subunit of the insulin receptor Journal of Cellular Biochemistry. 39: 429-441. PMID 2722971 DOI: 10.1002/Jcb.240390409 |
0.446 |
|
| 1989 |
Beguinot F, Kahn CR, Moses AC, White MF, Smith RJ. Differentiation-dependent phosphorylation of a 175,000 molecular weight protein in response to insulin and insulin-like growth factor-I in L6 skeletal muscle cells. Endocrinology. 125: 1599-605. PMID 2667964 DOI: 10.1210/endo-125-3-1599 |
0.463 |
|
| 1989 |
Kahn CR, Goldstein BJ. Molecular defects in insulin action. Science (New York, N.Y.). 245: 13. PMID 2662406 DOI: 10.1126/SCIENCE.2662406 |
0.392 |
|
| 1989 |
Reddy SS, Muller-Wieland D, Kriauciunas K, Kahn CR. Molecular defects in the insulin receptor in patients with leprechaunism and in their parents. The Journal of Laboratory and Clinical Medicine. 114: 165-70. PMID 2569023 |
0.406 |
|
| 1989 |
Cox NJ, Spielman RS, Kahn CR, Muller-Wieland D, Kriauciunas KM, Taub R. Four RFLPs of the human insulin receptor gene: PstI, KpnI, RsaI (2 RFLPs). Nucleic Acids Research. 17: 820. PMID 2563579 DOI: 10.1093/nar/17.2.820 |
0.385 |
|
| 1989 |
Muller-Wieland D, Taub R, Tewari DS, Kriauciunas KM, Sethu S, Reddy K, Kahn CR. Insulin-receptor gene and its expression in patients with insulin resistance. Diabetes. 38: 31-8. PMID 2562832 DOI: 10.2337/diab.38.1.31 |
0.432 |
|
| 1989 |
Hurrell DG, Pedersen O, Kahn CR. Alterations in the hepatic insulin receptor kinase in genetic and acquired obesity in rats. Endocrinology. 125: 2454-2462. PMID 2551653 DOI: 10.1210/Endo-125-5-2454 |
0.421 |
|
| 1989 |
Meyerovitch J, Backer JM, Kahn CR. Hepatic phosphotyrosine phosphatase activity and its alterations in diabetic rats Journal of Clinical Investigation. 84: 976-983. PMID 2547842 DOI: 10.1172/Jci114261 |
0.319 |
|
| 1989 |
Kahn CR, Lauris V, Koch S, Crettaz M, Granner DK. Acute and chronic regulation of phosphoenolpyruvate carboxykinase mRNA by insulin and glucose Molecular Endocrinology. 3: 840-845. PMID 2547157 DOI: 10.1210/Mend-3-5-840 |
0.409 |
|
| 1989 |
Goldstein BJ, Kahn CR. Analysis of mRNA heterogeneity by ribonuclease H mapping: application to the insulin receptor. Biochemical and Biophysical Research Communications. 159: 664-669. PMID 2539119 DOI: 10.1016/0006-291X(89)90046-6 |
0.436 |
|
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