| Year |
Citation |
Score |
| 2020 |
Kadyrova LY, Gujar V, Burdett V, Modrich PL, Kadyrov FA. Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion. Proceedings of the National Academy of Sciences of the United States of America. PMID 32015124 DOI: 10.1073/Pnas.1914718117 |
0.568 |
|
| 2018 |
Sherrer SM, Penland E, Modrich P. The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29941579 DOI: 10.1073/Pnas.1807319115 |
0.427 |
|
| 2017 |
Genschel J, Kadyrova LY, Iyer RR, Dahal BK, Kadyrov FA, Modrich P. Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repair. Proceedings of the National Academy of Sciences of the United States of America. PMID 28439008 DOI: 10.1073/Pnas.1702561114 |
0.702 |
|
| 2016 |
Modrich P. Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture). Angewandte Chemie (International Ed. in English). 55: 8490-501. PMID 27198632 DOI: 10.1002/Anie.201601412 |
0.541 |
|
| 2016 |
Lindahl T, Modrich P, Sancar A. The 2015 Nobel Prize in Chemistry The Discovery of Essential Mechanisms that Repair DNA Damage. Journal of the Association of Genetic Technologists. 42: 37-41. PMID 27183258 |
0.482 |
|
| 2016 |
Chen YS, Wu J, Modrich P, Hsieh TS. Carboxyl-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCT Domain-containing Protein Mus101 and Fidelity of DNA Segregation. The Journal of Biological Chemistry. PMID 27129233 DOI: 10.1074/Jbc.M116.721357 |
0.363 |
|
| 2015 |
Qiu R, Sakato M, Sacho EJ, Wilkins H, Zhang X, Modrich P, Hingorani MM, Erie DA, Weninger KR. MutL traps MutS at a DNA mismatch. Proceedings of the National Academy of Sciences of the United States of America. 112: 10914-9. PMID 26283381 DOI: 10.1073/Pnas.1505655112 |
0.556 |
|
| 2014 |
Shao H, Baitinger C, Soderblom EJ, Burdett V, Modrich P. Hydrolytic function of Exo1 in mammalian mismatch repair. Nucleic Acids Research. 42: 7104-12. PMID 24829455 DOI: 10.1093/Nar/Gku420 |
0.469 |
|
| 2014 |
Lindsey-Boltz LA, Kemp MG, Reardon JT, DeRocco V, Iyer RR, Modrich P, Sancar A. Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. The Journal of Biological Chemistry. 289: 5074-82. PMID 24403078 DOI: 10.1074/Jbc.M113.542787 |
0.741 |
|
| 2013 |
Pluciennik A, Burdett V, Baitinger C, Iyer RR, Shi K, Modrich P. Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation. Proceedings of the National Academy of Sciences of the United States of America. 110: 12277-82. PMID 23840062 DOI: 10.1073/Pnas.1311325110 |
0.723 |
|
| 2011 |
Liu Y, Kadyrov FA, Modrich P. PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro Dna Repair. 10: 1145-1153. PMID 21945626 DOI: 10.1016/J.Dnarep.2011.08.012 |
0.525 |
|
| 2011 |
Tseng Q, Orans J, Hast MA, Iyer RR, Changela A, Modrich PL, Beese LS. Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 947-52. PMID 21821902 DOI: 10.1107/S1744309111019300 |
0.681 |
|
| 2011 |
Orans J, McSweeney EA, Iyer RR, Hast MA, Hellinga HW, Modrich P, Beese LS. Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. Cell. 145: 212-23. PMID 21496642 DOI: 10.1016/J.Cell.2011.03.005 |
0.712 |
|
| 2011 |
Nimonkar AV, Genschel J, Kinoshita E, Polaczek P, Campbell JL, Wyman C, Modrich P, Kowalczykowski SC. BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair Genes and Development. 25: 350-362. PMID 21325134 DOI: 10.1101/Gad.2003811 |
0.597 |
|
| 2011 |
Orans J, McSweeney E, Modrich P, Beese LS. Crystal Structures of Human Exonuclease I with DNA Provides Insight into Substrate Selectivity and Mechanism Biophysical Journal. 100: 241a. DOI: 10.1016/J.Bpj.2010.12.1533 |
0.565 |
|
| 2010 |
Pluciennik A, Dzantiev L, Iyer RR, Constantin N, Kadyrov FA, Modrich P. PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair. Proceedings of the National Academy of Sciences of the United States of America. 107: 16066-71. PMID 20713735 DOI: 10.1073/Pnas.1010662107 |
0.733 |
|
| 2010 |
van Oers JM, Roa S, Werling U, Liu Y, Genschel J, Hou H, Sellers RS, Modrich P, Scharff MD, Edelmann W. PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance. Proceedings of the National Academy of Sciences of the United States of America. 107: 13384-9. PMID 20624957 DOI: 10.1073/Pnas.1008589107 |
0.38 |
|
| 2010 |
Pillon MC, Lorenowicz JJ, Uckelmann M, Klocko AD, Mitchell RR, Chung YS, Modrich P, Walker GC, Simmons LA, Friedhoff P, Guarné A. Structure of the endonuclease domain of MutL: unlicensed to cut. Molecular Cell. 39: 145-51. PMID 20603082 DOI: 10.1016/J.Molcel.2010.06.027 |
0.512 |
|
| 2010 |
Iyer RR, Pluciennik A, Genschel J, Tsai MS, Beese LS, Modrich P. MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta. The Journal of Biological Chemistry. 285: 11730-9. PMID 20154325 DOI: 10.1074/Jbc.M110.104125 |
0.667 |
|
| 2010 |
Liu Y, Fang Y, Shao H, Lindsey-Boltz L, Sancar A, Modrich P. Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway. The Journal of Biological Chemistry. 285: 5974-82. PMID 20029092 DOI: 10.1074/Jbc.M109.076109 |
0.453 |
|
| 2009 |
Pluciennik A, Burdett V, Lukianova O, O'Donnell M, Modrich P. Involvement of the beta clamp in methyl-directed mismatch repair in vitro. The Journal of Biological Chemistry. 284: 32782-91. PMID 19783657 DOI: 10.1074/Jbc.M109.054528 |
0.625 |
|
| 2009 |
Genschel J, Modrich P. Functions of MutLα, replication protein A (RPA), and HMGB1 in 5′-directed mismatch repair Journal of Biological Chemistry. 284: 21536-21544. PMID 19515846 DOI: 10.1074/Jbc.M109.021287 |
0.47 |
|
| 2009 |
Zhao J, Jain A, Iyer RR, Modrich PL, Vasquez KM. Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks. Nucleic Acids Research. 37: 4420-9. PMID 19468048 DOI: 10.1093/Nar/Gkp399 |
0.743 |
|
| 2009 |
Kadyrov FA, Genschel J, Fang Y, Penland E, Edelmann W, Modrich P. A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair. Proceedings of the National Academy of Sciences of the United States of America. 106: 8495-500. PMID 19420220 DOI: 10.1073/Pnas.0903654106 |
0.555 |
|
| 2009 |
Jiang Y, Marszalek PE, Baitinger C, Modrich P. AFM Visualization of the Interaction between MutS and Heteroduplex DNA Biophysical Journal. 96: 396a. DOI: 10.1016/J.Bpj.2008.12.2015 |
0.594 |
|
| 2008 |
Nimonkar AV, Özsoy AZ, Genschel J, Modrich P, Kowalczykowski SC. Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair Proceedings of the National Academy of Sciences of the United States of America. 105: 16906-16911. PMID 18971343 DOI: 10.1073/Pnas.0809380105 |
0.605 |
|
| 2008 |
Maxwell JA, Johnson SP, McLendon RE, Lister DW, Horne KS, Rasheed A, Quinn JA, Ali-Osman F, Friedman AH, Modrich PL, Bigner DD, Friedman HS. Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 4859-68. PMID 18676759 DOI: 10.1158/1078-0432.Ccr-07-4807 |
0.404 |
|
| 2008 |
Iyer RR, Pohlhaus TJ, Chen S, Hura GL, Dzantiev L, Beese LS, Modrich P. The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair. The Journal of Biological Chemistry. 283: 13310-9. PMID 18326858 DOI: 10.1074/Jbc.M800606200 |
0.709 |
|
| 2008 |
Sacho EJ, Kadyrov FA, Modrich P, Kunkel TA, Erie DA. Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha. Molecular Cell. 29: 112-21. PMID 18206974 DOI: 10.1016/J.Molcel.2007.10.030 |
0.355 |
|
| 2007 |
Kadyrov FA, Holmes SF, Arana ME, Lukianova OA, O'Donnell M, Kunkel TA, Modrich P. Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease. The Journal of Biological Chemistry. 282: 37181-90. PMID 17951253 DOI: 10.1074/Jbc.M707617200 |
0.61 |
|
| 2007 |
Pluciennik A, Modrich P. Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair Proceedings of the National Academy of Sciences of the United States of America. 104: 12709-12713. PMID 17620611 DOI: 10.1073/Pnas.0705129104 |
0.51 |
|
| 2007 |
Warren JJ, Pohlhaus TJ, Changela A, Iyer RR, Modrich PL, Beese LS. Structure of the human MutSalpha DNA lesion recognition complex. Molecular Cell. 26: 579-92. PMID 17531815 DOI: 10.1016/J.Molcel.2007.04.018 |
0.706 |
|
| 2006 |
Modrich P. Mechanisms in eukaryotic mismatch repair Journal of Biological Chemistry. 281: 30305-30309. PMID 16905530 DOI: 10.1074/Jbc.R600022200 |
0.526 |
|
| 2006 |
Kadyrov FA, Dzantiev L, Constantin N, Modrich P. Endonucleolytic function of MutLalpha in human mismatch repair. Cell. 126: 297-308. PMID 16873062 DOI: 10.1016/J.Cell.2006.05.039 |
0.57 |
|
| 2006 |
Genschel J, Modrich P. Analysis of the Excision Step in Human DNA Mismatch Repair Methods in Enzymology. 408: 273-284. PMID 16793375 DOI: 10.1016/S0076-6879(06)08017-7 |
0.549 |
|
| 2006 |
York SJ, Modrich P. Mismatch repair-dependent iterative excision at irreparable O 6-methylguanine lesions in human nuclear extracts Journal of Biological Chemistry. 281: 22674-22683. PMID 16772289 DOI: 10.1074/Jbc.M603667200 |
0.546 |
|
| 2006 |
López de Saro FJ, Marinus MG, Modrich P, O'Donnell M. The beta sliding clamp binds to multiple sites within MutL and MutS. The Journal of Biological Chemistry. 281: 14340-9. PMID 16546997 DOI: 10.1074/Jbc.M601264200 |
0.568 |
|
| 2006 |
Iyer RR, Pluciennik A, Burdett V, Modrich PL. DNA mismatch repair: functions and mechanisms. Chemical Reviews. 106: 302-23. PMID 16464007 DOI: 10.1021/Cr0404794 |
0.727 |
|
| 2005 |
Constantin N, Dzantiev L, Kadyrov FA, Modrich P. Human mismatch repair: reconstitution of a nick-directed bidirectional reaction. The Journal of Biological Chemistry. 280: 39752-61. PMID 16188885 DOI: 10.1074/Jbc.M509701200 |
0.62 |
|
| 2005 |
Cheng CL, Johnson SP, Keir ST, Quinn JA, Ali-Osman F, Szabo C, Li H, Salzman AL, Dolan ME, Modrich P, Bigner DD, Friedman HS. Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft. Molecular Cancer Therapeutics. 4: 1364-8. PMID 16170028 DOI: 10.1158/1535-7163.Mct-05-0128 |
0.418 |
|
| 2005 |
Koshiji M, To KKW, Hammer S, Kumamoto K, Harris AL, Modrich P, Huang LE. HIF-1α induces genetic instability by transcriptionally downregulating MutSα expression Molecular Cell. 17: 793-803. PMID 15780936 DOI: 10.1016/J.Molcel.2005.02.015 |
0.306 |
|
| 2005 |
Lu AL, Clark S, Modrich P. Methyl-directed repair of DNA base-pair mismatches in vitro. 1983 Dna Repair. 4: 134-138; discussion . PMID 15533843 DOI: 10.1016/J.Dnarep.2004.07.003 |
0.451 |
|
| 2004 |
Dzantiev L, Constantin N, Genschel J, Iyer RR, Burgers PM, Modrich P. A defined human system that supports bidirectional mismatch-provoked excision. Molecular Cell. 15: 31-41. PMID 15225546 DOI: 10.1016/J.Molcel.2004.06.016 |
0.686 |
|
| 2004 |
Martik D, Baitinger C, Modrich P. Differential specificities and simultaneous occupancy of human MutSα nucleotide binding sites Journal of Biological Chemistry. 279: 28402-28410. PMID 15105434 DOI: 10.1074/Jbc.M312108200 |
0.327 |
|
| 2004 |
Yang Q, Zhang R, Wang XW, Linke SP, Sengupta S, Hickson ID, Pedrazzi G, Perrera C, Stagljar I, Littman SJ, Modrich P, Harris CC. The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase Oncogene. 23: 3749-3756. PMID 15064730 DOI: 10.1038/Sj.Onc.1207462 |
0.583 |
|
| 2003 |
Genschel J, Modrich P. Mechanism of 5′-directed excision in human mismatch repair Molecular Cell. 12: 1077-1086. PMID 14636568 DOI: 10.1016/S1097-2765(03)00428-3 |
0.465 |
|
| 2003 |
Baitinger C, Burdett V, Modrich P. Hydrolytically deficient MutS E694A is defective in the MutL-dependent activation of MutH and in the mismatch-dependent assembly of the MutS.MutL.heteroduplex complex. The Journal of Biological Chemistry. 278: 49505-11. PMID 14506224 DOI: 10.1074/Jbc.M308738200 |
0.495 |
|
| 2003 |
Bjornson KP, Blackwell LJ, Sage H, Baitinger C, Allen D, Modrich P. Assembly and Molecular Activities of the MutS Tetramer Journal of Biological Chemistry. 278: 34667-34673. PMID 12829697 DOI: 10.1074/Jbc.M305513200 |
0.381 |
|
| 2003 |
Bjornson KP, Modrich P. Differential and simultaneous adenosine di- and triphosphate binding by MutS Journal of Biological Chemistry. 278: 18557-18562. PMID 12624105 DOI: 10.1074/Jbc.M301101200 |
0.343 |
|
| 2002 |
Genschel J, Bazemore LR, Modrich P. Human exonuclease I is required for 5′ and 3′ mismatch repair Journal of Biological Chemistry. 277: 13302-13311. PMID 11809771 DOI: 10.1074/Jbc.M111854200 |
0.474 |
|
| 2001 |
Chen S, Bigner SH, Modrich P. High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6. Proceedings of the National Academy of Sciences of the United States of America. 98: 13802-7. PMID 11717437 DOI: 10.1073/Pnas.241508098 |
0.452 |
|
| 2001 |
Blackwell LJ, Bjornson KP, Allen DJ, Modrich P. Distinct MutS DNA-binding Modes That Are Differentially Modulated by ATP Binding and Hydrolysis Journal of Biological Chemistry. 276: 34339-34347. PMID 11454861 DOI: 10.1074/Jbc.M104256200 |
0.46 |
|
| 2001 |
Blackwell LJ, Wang S, Modrich P. DNA Chain Length Dependence of Formation and Dynamics of hMutSα·hMutLα·Heteroduplex Complexes Journal of Biological Chemistry. 276: 33233-33240. PMID 11441019 DOI: 10.1074/Jbc.M105076200 |
0.463 |
|
| 2001 |
Viswanathan M, Burdett V, Baitinger C, Modrich P, Lovett ST. Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair. The Journal of Biological Chemistry. 276: 31053-8. PMID 11418610 DOI: 10.1074/Jbc.M105481200 |
0.519 |
|
| 2001 |
Burdett V, Baitinger C, Viswanathan M, Lovett ST, Modrich P. In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair. Proceedings of the National Academy of Sciences of the United States of America. 98: 6765-70. PMID 11381137 DOI: 10.1073/Pnas.121183298 |
0.486 |
|
| 2000 |
Ma AH, Xia L, Littman SJ, Swinler S, Lader G, Polinkovsky A, Olechnowicz J, Kasturi L, Lutterbaugh J, Modrich P, Veigl ML, Markowitz SD, Sedwick WD. Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability Oncogene. 19: 2249-2256. PMID 10822375 DOI: 10.1038/Sj.Onc.1203568 |
0.406 |
|
| 2000 |
Hoyt PR, Doktycz MJ, Modrich P, Warmack RJ, Allison DP. Identifying sequence similarities between DNA molecules Ultramicroscopy. 82: 237-244. PMID 10741675 DOI: 10.1016/S0304-3991(99)00153-9 |
0.492 |
|
| 2000 |
Spampinato C, Modrich P. The MutL ATPase is required for mismatch repair Journal of Biological Chemistry. 275: 9863-9869. PMID 10734142 DOI: 10.1074/Jbc.275.13.9863 |
0.543 |
|
| 2000 |
Bjornson KP, Allen DJ, Modrich P. Modulation of MutS ATP hydrolysis by DNA cofactors Biochemistry. 39: 3176-3183. PMID 10715140 DOI: 10.1021/Bi992286U |
0.475 |
|
| 1999 |
Wright DJ, Jack WE, Modrich P. The kinetic mechanism of EcoRI endonuclease Journal of Biological Chemistry. 274: 31896-31902. PMID 10542216 DOI: 10.1074/Jbc.274.45.31896 |
0.594 |
|
| 1999 |
Duckett DR, Bronstein SM, Taya Y, Modrich P. hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage Proceedings of the National Academy of Sciences of the United States of America. 96: 12384-12388. PMID 10535931 DOI: 10.1073/pnas.96.22.12384 |
0.352 |
|
| 1999 |
Littman SJ, Fang WH, Modrich P. Repair of large insertion/deletion heterologies in human nuclear extracts is directed by a 5' single-strand break and is independent of the mismatch repair system Journal of Biological Chemistry. 274: 7474-7481. PMID 10066813 DOI: 10.1074/Jbc.274.11.7474 |
0.563 |
|
| 1999 |
Friedman HS, Pegg AE, Johnson SP, Loktionova NA, Dolan ME, Modrich P, Moschel RC, Struck R, Brent TP, Ludeman S, Bullock N, Kilborn C, Keir S, Dong Q, Bigner DD, et al. Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase. Cancer Chemotherapy and Pharmacology. 43: 80-5. PMID 9923545 DOI: 10.1007/S002800050866 |
0.438 |
|
| 1999 |
Dong Q, Johnson SP, Colvin OM, Bullock N, Kilborn C, Runyon G, Sullivan DM, Easton J, Bigner DD, Nahta R, Marks J, Modrich P, Friedman HS. Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR). Cancer Chemotherapy and Pharmacology. 43: 73-9. PMID 9923544 DOI: 10.1007/S002800050865 |
0.401 |
|
| 1999 |
Blackwell LJ, Martik D, Bjornson KP, Bjornson ES, Modrich P. Nucleotide-promoted release of hMutSα from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism Journal of Biological Chemistry. 273: 32055-32062. PMID 9822680 DOI: 10.1074/Jbc.273.48.32055 |
0.48 |
|
| 1999 |
Blackwell LJ, Bjornson KP, Modrich P. DNA-dependent activation of the hMutSα ATPase Journal of Biological Chemistry. 273: 32049-32054. PMID 9822679 DOI: 10.1074/Jbc.273.48.32049 |
0.572 |
|
| 1998 |
Friedman HS, McLendon RE, Kerby T, Dugan M, Bigner SH, Henry AJ, Ashley DM, Krischer J, Lovell S, Rasheed K, Marchev F, Seman AJ, Cokgor I, Rich J, Stewart E, ... ... Modrich PL, et al. DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 16: 3851-7. PMID 9850030 DOI: 10.1200/Jco.1998.16.12.3851 |
0.43 |
|
| 1998 |
Genschel J, Littman SJ, Drummond JT, Modrich P. Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. The Journal of Biological Chemistry. 273: 19895-901. PMID 9677427 DOI: 10.1074/Jbc.273.31.19895 |
0.439 |
|
| 1998 |
Veigl ML, Kasturi L, Olechnowicz J, Ma AH, Lutterbaugh JD, Periyasamy S, Li GM, Drummond J, Modrich PL, Sedwick WD, Markowitz SD. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proceedings of the National Academy of Sciences of the United States of America. 95: 8698-702. PMID 9671741 DOI: 10.1073/pnas.95.15.8698 |
0.333 |
|
| 1998 |
Lee SE, Johnson SP, Hale LP, Li J, Bullock N, Fuchs H, Friedman A, McLendon R, Bigner DD, Modrich P, Friedman HS. Analysis of DNA mismatch repair proteins in human medulloblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 4: 1415-9. PMID 9626457 |
0.442 |
|
| 1998 |
Dao V, Modrich P. Mismatch-, MutS-, MutL-, and helicase II-dependent unwinding from the single-strand break of an incised heteroduplex Journal of Biological Chemistry. 273: 9202-9207. PMID 9535911 DOI: 10.1074/Jbc.273.15.9202 |
0.558 |
|
| 1998 |
Yamaguchi M, Dao V, Modrich P. MutS and MutL activate DNA helicase II in a mismatch-dependent manner Journal of Biological Chemistry. 273: 9197-9201. PMID 9535910 DOI: 10.1074/Jbc.273.15.9197 |
0.575 |
|
| 1998 |
Eshleman JR, Donover PS, Littman SJ, Swinler SE, Li GM, Lutterbaugh JD, Willson JKV, Modrich P, Sedwick WD, Markowitz SD, Veigl ML. Increased transversions in a novel mutator colon cancer cell line Oncogene. 16: 1125-1130. PMID 9528854 DOI: 10.1038/Sj.Onc.1201629 |
0.329 |
|
| 1998 |
Nicolaides NC, Littman SJ, Modrich P, Kinzler KW, Vogelstein B. A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype Molecular and Cellular Biology. 18: 1635-1641. PMID 9488480 DOI: 10.1128/Mcb.18.3.1635 |
0.311 |
|
| 1997 |
Modrich P. Strand-specific mismatch repair in mammalian cells Journal of Biological Chemistry. 272: 24727-24730. PMID 9312062 DOI: 10.1074/Jbc.272.40.24727 |
0.563 |
|
| 1997 |
Drummond JT, Genschel J, Wolf E, Modrich P. DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. Proceedings of the National Academy of Sciences of the United States of America. 94: 10144-9. PMID 9294177 DOI: 10.1073/Pnas.94.19.10144 |
0.356 |
|
| 1997 |
Allen DJ, Makhov A, Grilley M, Taylor J, Thresher R, Modrich P, Griffith JD. MutS mediates heteroduplex loop formation by a translocation mechanism Embo Journal. 16: 4467-4476. PMID 9250691 DOI: 10.1093/Emboj/16.14.4467 |
0.52 |
|
| 1997 |
Smith J, Modrich P. Removal of polymerase-produced mutant sequences from PCR products Proceedings of the National Academy of Sciences of the United States of America. 94: 6847-6850. PMID 9192654 DOI: 10.1073/Pnas.94.13.6847 |
0.409 |
|
| 1997 |
Allison DP, Kerper PS, Doktycz MJ, Thundat T, Modrich P, Larimer FW, Johnson DK, Hoyt PR, Mucenski ML, Warmack RJ. Mapping individual cosmid DNAs by direct AFM imaging Genomics. 41: 379-384. PMID 9169135 DOI: 10.1006/Geno.1997.4686 |
0.486 |
|
| 1997 |
Longley MJ, Pierce AJ, Modrich P. DNA polymerase δ is required for human mismatch repair in vitro Journal of Biological Chemistry. 272: 10917-10921. PMID 9099749 DOI: 10.1074/Jbc.272.16.10917 |
0.589 |
|
| 1997 |
Mu D, Tursun M, Duckett DR, Drummond JT, Modrich P, Sancar A. Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. Molecular and Cellular Biology. 17: 760-9. PMID 9001230 DOI: 10.1128/Mcb.17.2.760 |
0.516 |
|
| 1997 |
Drummond J, Duckett D, Genschel J, Lonyley M, Pierce A, Litlman S, Li GM, Modrich P. MutSα MutSβ, MutLα and DNA polymerase ôin human mismatch repair Faseb Journal. 11: A1012. |
0.49 |
|
| 1996 |
Modrich P, Lahue R. Mismatch repair in replication fidelity, genetic recombination, and cancer biology Annual Review of Biochemistry. 65: 101-133. PMID 8811176 DOI: 10.1146/Annurev.Bi.65.070196.000533 |
0.548 |
|
| 1996 |
Allison DP, Kerper PS, Doktycz MJ, Spain JA, Modrich P, Larimer FW, Thundat T, Warmack RJ. Direct atomic force microscope imaging of EcoRI endonuclease site specifically bound to plasmid DNA molecules Proceedings of the National Academy of Sciences of the United States of America. 93: 8826-8829. PMID 8799111 DOI: 10.1073/Pnas.93.17.8826 |
0.429 |
|
| 1996 |
Iaccarino I, Palombo F, Drummond J, Totty NF, Hsuan JJ, Modrich P, Jiricny J. MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2 Current Biology. 6: 484-486. PMID 8723353 DOI: 10.1016/S0960-9822(02)00516-X |
0.538 |
|
| 1996 |
Drummond JT, Anthoney A, Brown R, Modrich P. Cisplatin and adriamycin resistance are associated with MutLα and mismatch repair deficiency in an ovarian tumor cell line Journal of Biological Chemistry. 271: 19645-19648. PMID 8702663 DOI: 10.1074/Jbc.271.33.19645 |
0.373 |
|
| 1996 |
Duckett DR, Drummond JT, Murchie AIH, Reardon JT, Sancar A, Lilley DMJ, Modrich P. Humnan MutSα recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct Proceedings of the National Academy of Sciences of the United States of America. 93: 6443-6447. PMID 8692834 DOI: 10.1073/Pnas.93.13.6443 |
0.542 |
|
| 1996 |
Smith J, Modrich P. Mutation detection with MutH, MutL, and MutS mismatch repair proteins Proceedings of the National Academy of Sciences of the United States of America. 93: 4374-4379. PMID 8633074 DOI: 10.1073/Pnas.93.9.4374 |
0.413 |
|
| 1995 |
Dong Q, Barsky D, Colvin ME, Melius CF, Ludeman SM, Moravek JF, Colvin OM, Bigner DD, Modrich P, Friedman HS. A structural basis for a phosphoramide mustard-induced DNA interstrand cross-link at 5'-d(GAC). Proceedings of the National Academy of Sciences of the United States of America. 92: 12170-4. PMID 8618865 DOI: 10.1073/Pnas.92.26.12170 |
0.44 |
|
| 1995 |
Li GM, Modrich P. Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs Proceedings of the National Academy of Sciences of the United States of America. 92: 1950-1954. PMID 7892206 DOI: 10.1073/Pnas.92.6.1950 |
0.477 |
|
| 1995 |
Modrich P. Mismatch repair, genetic stability, and cancer. Science (New York, N.Y.). 266: 1959-60. PMID 7801122 DOI: 10.1126/Science.7801122 |
0.313 |
|
| 1995 |
Modrich P. Mismatch repair, genetic stability and tumour avoidance. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 347: 89-95. PMID 7746860 DOI: 10.1098/Rstb.1995.0014 |
0.546 |
|
| 1995 |
Parsons R, Li GM, Longley M, Modrich P, Liu B, Berk T, Hamilton SR, Kinzler KW, Vogelstein B. Mismatch repair deficiency in phenotypically normal human cells Science. 268: 738-740. PMID 7632227 DOI: 10.1126/Science.7632227 |
0.433 |
|
| 1995 |
Drummond JT, Li GM, Longley MJ, Modrich P. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells Science. 268: 1909-1912. PMID 7604264 DOI: 10.1126/Science.7604264 |
0.448 |
|
| 1994 |
Parsons R, Li GM, Longley MJ, Fang WH, Papadopoulos N, Jen J, de la Chapelle A, Kinzler KW, Vogelstein B, Modrich P. Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell. 75: 1227-36. PMID 8261516 DOI: 10.1016/0092-8674(93)90331-J |
0.356 |
|
| 1994 |
Worth L, Clark S, Radman M, Modrich P. Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs. Proceedings of the National Academy of Sciences of the United States of America. 91: 3238-41. PMID 8159731 DOI: 10.1073/Pnas.91.8.3238 |
0.492 |
|
| 1993 |
Nelson SF, McCusker JH, Sander MA, Kee Y, Modrich P, Brown PO. Genomic mismatch scanning: a new approach to genetic linkage mapping. Nature Genetics. 4: 11-18. PMID 8513319 DOI: 10.1038/Ng0593-11 |
0.337 |
|
| 1993 |
Kat A, Thilly WG, Fang WH, Longley MJ, Li GM, Modrich P. An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proceedings of the National Academy of Sciences of the United States of America. 90: 6424-6428. PMID 8341649 DOI: 10.1073/Pnas.90.14.6424 |
0.454 |
|
| 1993 |
Fang W-, Li G-, Longley M, Holmes J, Thilly W, Modrich P. Mismatch repair and genetic stability in human cells. Cold Spring Harbor Symposia On Quantitative Biology. 58: 597-603. PMID 7956074 DOI: 10.1101/Sqb.1993.058.01.066 |
0.35 |
|
| 1992 |
Modrich P. Mechanisms and biological effects of mismatch repair. Annual Review of Genetics. 25: 229-53. PMID 1812808 DOI: 10.1146/Annurev.Ge.25.120191.001305 |
0.463 |
|
| 1990 |
Grilley M, Holmes J, Yashar B, Modrich P. Mechanisms of DNA-mismatch correction. Mutation Research-Dna Repair. 236: 253-267. PMID 2144613 DOI: 10.1016/0921-8777(90)90009-T |
0.541 |
|
| 1990 |
Holmes J, Clark S, Modrich P. Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. Proceedings of the National Academy of Sciences of the United States of America. 87: 5837-5841. PMID 2116007 DOI: 10.1073/Pnas.87.15.5837 |
0.568 |
|
| 1989 |
Su SS, Grilley M, Thresher R, Griffith J, Modrich P. Gap formation is associated with methyl-directed mismatch correction under conditions of restricted DNA synthesis. Genome / National Research Council Canada = GéNome / Conseil National De Recherches Canada. 31: 104-11. PMID 2687086 DOI: 10.1139/G89-020 |
0.551 |
|
| 1989 |
Au KG, Clark S, Miller JH, Modrich P. Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs Proceedings of the National Academy of Sciences of the United States of America. 86: 8877-8881. PMID 2682664 DOI: 10.1073/Pnas.86.22.8877 |
0.467 |
|
| 1989 |
Lahue RS, Au KG, Modrich P. DNA mismatch correction in a defined system Science. 245: 160-164. PMID 2665076 DOI: 10.1126/Science.2665076 |
0.587 |
|
| 1988 |
Lahue RS, Modrich P. Methyl-directed DNA mismatch repair in Escherichia coli Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 198: 37-43. PMID 3280983 DOI: 10.1016/0027-5107(88)90037-1 |
0.487 |
|
| 1988 |
Au KG, Cabrera M, Miller JH, Modrich P. Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction Proceedings of the National Academy of Sciences of the United States of America. 85: 9163-9166. PMID 3057502 DOI: 10.1073/Pnas.85.23.9163 |
0.389 |
|
| 1988 |
Jiricny J, Su SS, Wood SG, Modrich P. Mismatch-containing oligonucleotide duplexes bound by the E. coli mutS-encoded protein. Nucleic Acids Research. 16: 7843-53. PMID 3047673 DOI: 10.1093/Nar/16.16.7843 |
0.427 |
|
| 1988 |
Jhon NI, Casas-Finet JR, Maki AH, Modrich P. Investigation of the complexes of EcoRI endonuclease with decanucleotides containing canonical and modified recognition sequences using fluorescence and optical detection of magnetic resonance spectroscopy. Biochimica Et Biophysica Acta. 949: 189-94. PMID 2829965 DOI: 10.1016/0167-4781(88)90082-6 |
0.326 |
|
| 1987 |
Lahue RS, Su SS, Modrich P. Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correction. Proceedings of the National Academy of Sciences of the United States of America. 84: 1482-6. PMID 3550791 DOI: 10.1073/Pnas.84.6.1482 |
0.458 |
|
| 1987 |
Modrich P. DNA Mismatch Correction Annual Review of Biochemistry. 56: 435-466. PMID 3304141 DOI: 10.1146/Annurev.Bi.56.070187.002251 |
0.542 |
|
| 1986 |
Su SS, Modrich P. Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs. Proceedings of the National Academy of Sciences of the United States of America. 83: 5057-61. PMID 3014530 DOI: 10.1073/Pnas.83.14.5057 |
0.468 |
|
| 1984 |
Lu AL, Welsh K, Clark S, Su SS, Modrich P. Repair of DNA base-pair mismatches in extracts of Escherichia coli. Cold Spring Harbor Symposia On Quantitative Biology. 49: 589-96. PMID 6397313 DOI: 10.1101/Sqb.1984.049.01.066 |
0.542 |
|
| 1984 |
Kim R, Modrich P, Kim S. ‘Interactive’ recognition in EcoRl restriction enzyme-DNA complex Nucleic Acids Research. 12: 7285-7292. PMID 6093038 DOI: 10.1093/Nar/12.19.7285 |
0.536 |
|
| 1983 |
Lu AL, Clark S, Modrich P. Methyl-directed repair of DNA base-pair mismatches in vitro Proceedings of the National Academy of Sciences of the United States of America. 80: 4639-4643. PMID 6308634 DOI: 10.1073/Pnas.80.15.4639 |
0.582 |
|
| 1982 |
Jack WE, Terry BJ, Modrich P. Involvement of outside DNA sequences in the major kinetic path by which EcoRI endonuclease locates and leaves its recognition sequence Proceedings of the National Academy of Sciences of the United States of America. 79: 4010-4014. PMID 6287460 DOI: 10.1073/Pnas.79.13.4010 |
0.523 |
|
| 1982 |
Modrich P, Roberts RJ. Type-II Restriction and Modification Enzymes Cold Spring Harbor Monograph Archive. 14: 109-154. DOI: 10.1101/087969155.14.109 |
0.409 |
|
| 1981 |
Young T, Kim S, Modrich P, Beth A, Jay E. Preliminary x-ray diffraction studies of EcoRI restriction endonuclease-DNA complex. Journal of Molecular Biology. 145: 607-10. PMID 6267292 DOI: 10.1016/0022-2836(81)90548-9 |
0.392 |
|
| 1980 |
Rubin RA, Modrich P. [12] Purification and properties of EcoRI endonuclease Methods in Enzymology. 65: 96-104. PMID 6246382 DOI: 10.1016/S0076-6879(80)65014-9 |
0.477 |
|
| 1979 |
Modrich P. Structures and mechanisms of DNA restriction and modification enzymes Quarterly Reviews of Biophysics. 12: 315-369. PMID 232555 DOI: 10.1017/S0033583500005461 |
0.517 |
|
| 1978 |
Rubin RA, Modrich P. Substrate dependence of the mechanism of EcoRI endonuclease Nucleic Acids Research. 5: 2991-2998. PMID 211492 DOI: 10.1093/Nar/5.8.2991 |
0.571 |
|
| 1974 |
Konrad EB, Modrich P, Lehman IR. DNA synthesis in strains of Escherichia coli K12 with temperature-sensitive DNA ligase and DNA polymerase I. Journal of Molecular Biology. 90: 115-26. PMID 4616094 DOI: 10.1016/0022-2836(74)90260-5 |
0.681 |
|
| 1973 |
Konrad EB, Modrich P, Lehman IR. Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase. Journal of Molecular Biology. 77: 519-29. PMID 4353283 DOI: 10.1016/0022-2836(73)90220-9 |
0.664 |
|
| 1971 |
Modrich P, Lehman IR. Enzymatic characterization of a mutant of Escherichia coli with an altered DNA ligase. Proceedings of the National Academy of Sciences of the United States of America. 68: 1002-5. PMID 4995816 DOI: 10.1073/Pnas.68.5.1002 |
0.668 |
|
| Show low-probability matches. |
