Arunesh Saras - Related publications

2019-2020 neurobiology Harvard Medical School, Boston, MA, United States 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Kharouf Q, Phillips AM, Bleakley LE, Morrisroe E, Oyrer J, Jia L, Ludwig A, Jin L, Nicolazzo JA, Cerbai E, Romanelli MN, Petrou S, Reid CA. The hyperpolarization-activated cyclic nucleotide-gated 4 channel as a potential anti-seizure drug target. British Journal of Pharmacology. PMID 32364262 DOI: 10.1111/bph.15088   
2020 Prakash C, Mishra M, Kumar P, Kumar V, Sharma D. Response of Voltage-Gated Sodium and Calcium Channels Subtypes on Dehydroepiandrosterone Treatment in Iron-Induced Epilepsy. Cellular and Molecular Neurobiology. PMID 32318899 DOI: 10.1007/s10571-020-00851-0   
2020 Sheilabi MA, Takeshita LY, Sims EJ, Falciani F, Princivalle AP. The Sodium Channel B4-Subunits are Dysregulated in Temporal Lobe Epilepsy Drug-Resistant Patients. International Journal of Molecular Sciences. 21. PMID 32331418 DOI: 10.3390/ijms21082955   
2020 Yuen Chow C, Absalom N, Biggs K, King GF, Ma L. Venom-derived modulators of epilepsy-related ion channels. Biochemical Pharmacology. 114043. PMID 32445870 DOI: 10.1016/j.bcp.2020.114043   
2020 Mason ER, Cummins TR. Differential Inhibition of Human Nav1.2 Resurgent and Persistent Sodium Currents by Cannabidiol and GS967. International Journal of Molecular Sciences. 21. PMID 32244818 DOI: 10.3390/ijms21072454   
2020 Akyüz E, Doğanyiğit Z, Paudel YN, Kaymak E, Yilmaz S, Uner A, Shaikh MF. Increased ACh-Associated Immunoreactivity in Autonomic Centers in PTZ Kindling Model of Epilepsy. Biomedicines. 8. PMID 32397136 DOI: 10.3390/biomedicines8050113   
2020 Chow CY, Chin YKY, Ma L, Undheim EAB, Herzig V, King GF. A selective na1.1 activator with potential for treatment of dravet syndrome epilepsy. Biochemical Pharmacology. 113991. PMID 32335140 DOI: 10.1016/j.bcp.2020.113991   
2020 Van Hoeymissen E, Held K, Nogueira Freitas AC, Janssens A, Voets T, Vriens J. Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy. Elife. 9. PMID 32427099 DOI: 10.7554/eLife.57190   
2020 Imbrici P, Nematian-Ardestani E, Hasan S, Pessia M, Tucker SJ, D'Adamo MC. Altered functional properties of a missense variant in the TRESK K channel (KCNK18) associated with migraine and intellectual disability. Pflugers Archiv : European Journal of Physiology. PMID 32394190 DOI: 10.1007/s00424-020-02382-5   
2020 Huang CW, Lai HJ, Lin PC, Lee MJ. Changes of Resurgent Na Currents in the Na1.4 Channel Resulting from an Mutation Contributing to Sodium Channel Myotonia. International Journal of Molecular Sciences. 21. PMID 32276507 DOI: 10.3390/ijms21072593   
2020 Yan R, Zhou Q, Xu Z, Zhu G, Dong K, Zhorov BS, Chen M. Three sodium channel mutations from Aedes albopictus confer resistance to Type I, but not Type II pyrethroids. Insect Biochemistry and Molecular Biology. 103411. PMID 32450204 DOI: 10.1016/j.ibmb.2020.103411   
2020 Taylor CP, Harris EW. Analgesia with Gabapentin and Pregabalin May Involve NMDA Receptors, Neurexins and Thrombospondins. The Journal of Pharmacology and Experimental Therapeutics. PMID 32321743 DOI: 10.1124/jpet.120.266056   
2020 Larsson JE, Karlsson U, Wu X, Liin SI. Combining endocannabinoids with retigabine for enhanced M-channel effect and improved KV7 subtype selectivity. The Journal of General Physiology. 152. PMID 32365171 DOI: 10.1085/jgp.202012576   
2020 Ghovanloo MR, Ruben PC. Say Cheese: Structure of the Cardiac Electrical Engine Is Captured. Trends in Biochemical Sciences. 45: 369-371. PMID 32311330 DOI: 10.1016/j.tibs.2020.02.003   
2020 Coburger I, Yang K, Bernert A, Wiesel E, Sahoo N, Swain SM, Hoshi T, Schönherr R, Heinemann SH. Impact of intracellular hemin on N-type inactivation of voltage-gated K channels. Pflugers Archiv : European Journal of Physiology. PMID 32388729 DOI: 10.1007/s00424-020-02386-1   
2020 Kshatri A, Cerrada A, Gimeno R, Bartolomé-Martín D, Rojas P, Giraldez T. Differential regulation of BK channels by fragile X mental retardation protein. The Journal of General Physiology. 152. PMID 32275741 DOI: 10.1085/jgp.201912502   
2020 Jenewein T, Kanner SA, Bauer D, Hertel B, Colecraft HM, Moroni A, Thiel G, Kauferstein S. The mutation L69P in the PAS domain of the hERG potassium channel results in LQTS by trafficking deficiency. Channels (Austin, Tex.). PMID 32253972 DOI: 10.1080/19336950.2020.1751522   
2020 Chow CY, Chin YK, Walker AA, Guo S, Blomster LV, Ward MJ, Herzig V, Rokyta DR, King GF. Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel Na1.1 Provide Novel Leads for Development of Antiepileptic Drugs. Acs Pharmacology & Translational Science. 3: 119-134. PMID 32259093 DOI: 10.1021/acsptsci.9b00079   
2020 Niu LG, Liu P, Wang ZW, Chen B. Slo2 potassium channel function depends on RNA editing-regulated expression of a SCYL1 protein. Elife. 9. PMID 32314960 DOI: 10.7554/eLife.53986   
2020 Cole BA, Johnson RM, Dejakaisaya H, Pilati N, Fishwick CWG, Muench SP, Lippiat JD. Structure-Based Identification and Characterization of Inhibitors of the Epilepsy-Associated K1.1 (KCNT1) Potassium Channel. Iscience. 23: 101100. PMID 32408169 DOI: 10.1016/j.isci.2020.101100   
2020 Pipatpolkai T, Usher S, Stansfeld PJ, Ashcroft FM. New insights into K channel gene mutations and neonatal diabetes mellitus. Nature Reviews. Endocrinology. PMID 32376986 DOI: 10.1038/s41574-020-0351-y   
2020 Al-Moubarak E, Zhang Y, Dempsey CE, Zhang H, Harmer SC, Hancox JC. Serine mutation of a conserved threonine in the hERG K channel S6-pore region leads to loss-of-function through trafficking impairment. Biochemical and Biophysical Research Communications. PMID 32321643 DOI: 10.1016/j.bbrc.2020.04.003   
2020 Vien TN, Wang J, Ng LCT, Cao E, DeCaen PG. Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain. Proceedings of the National Academy of Sciences of the United States of America. PMID 32332171 DOI: 10.1073/pnas.1920777117   
2020 Gantz SC, Moussawi K, Hake HS. Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons. Elife. 9. PMID 32234214 DOI: 10.7554/eLife.56054   
2020 Yang HQ, Martinez-Ortiz W, Hwang J, Fan X, Cardozo TJ, Coetzee WA. Palmitoylation of the K channel Kir6.2 subunit promotes channel opening by regulating PIP sensitivity. Proceedings of the National Academy of Sciences of the United States of America. PMID 32332165 DOI: 10.1073/pnas.1918088117   
2020 Ta CM, Vien TN, Ng LCT, DeCaen PG. Structure and function of polycystin channels in primary cilia. Cellular Signalling. 109626. PMID 32251715 DOI: 10.1016/j.cellsig.2020.109626   
2020 Bais S, Greenberg RM. Schistosome TRP channels: An appraisal. International Journal For Parasitology. Drugs and Drug Resistance. 13: 1-7. PMID 32250774 DOI: 10.1016/j.ijpddr.2020.02.002   
2020 Thompson AJ, Verdin PS, Burton MJ, Davies TGE, Williamson MS, Field LM, Baines RA, Mellor IR, Duce IR. The effects of knock-down resistance mutations and alternative splicing on voltage-gated sodium channels in Musca domestica and Drosophila melanogaster. Insect Biochemistry and Molecular Biology. 103388. PMID 32376273 DOI: 10.1016/j.ibmb.2020.103388   
2020 Davis MJ, Kim HJ, Zawieja SD, Castorena-Gonzalez JA, Gui P, Li M, Saunders BT, Zinselmeyer BH, Randolph GJ, Remedi MS, Nichols CG. Kir6.1-dependent K channels in lymphatic smooth muscle and vessel dysfunction in mice with Kir6.1 gain-of-function. The Journal of Physiology. PMID 32372450 DOI: 10.1113/JP279612   
2020 Davis MJ, Kim HJ, Zawieja SD, Castorena-Gonzalez JA, Gui P, Li M, Saunders BT, Zinselmeyer BH, Randolph GJ, Remedi MS, Nichols CG. Kir6.1-dependent K channels in lymphatic smooth muscle and vessel dysfunction in mice with Kir6.1 gain-of-function. The Journal of Physiology. PMID 32372450 DOI: 10.1113/JP279612   
2020 Thull S, Neacsu C, O'Reilly AO, Bothe S, Hausmann R, Huth T, Meents J, Lampert A. Mechanism underlying hooked resurgent-like tail currents induced by an insecticide in human cardiac Nav1.5. Toxicology and Applied Pharmacology. 115010. PMID 32302602 DOI: 10.1016/j.taap.2020.115010   
2020 Feria Pliego JA, Pedroarena CM. Kv1 potassium channels control action potential firing of putative GABAergic deep cerebellar nuclear neurons. Scientific Reports. 10: 6954. PMID 32332769 DOI: 10.1038/s41598-020-63583-7   
2020 Walther F, Feind D, Vom Dahl C, Müller CE, Kukaj T, Sattler C, Nagel G, Gao S, Zimmer T. Action potentials in Xenopus oocytes triggered by blue light. The Journal of General Physiology. 152. PMID 32211871 DOI: 10.1085/jgp.201912489   
2020 Inoue M, Matsuoka H, Harada K, Mugishima G, Kameyama M. TASK channels: channelopathies, trafficking, and receptor-mediated inhibition. Pflugers Archiv : European Journal of Physiology. PMID 32472332 DOI: 10.1007/s00424-020-02403-3   
2020 McDaniel MJ, Ogden KK, Kell SA, Burger PB, Liotta DC, Traynelis SF. NMDA receptor channel gating control by the pre-M1 helix. The Journal of General Physiology. 152. PMID 32221541 DOI: 10.1085/jgp.201912362   
2020 van Goor MK, de Jager L, Cheng Y, van der Wijst J. High-resolution structures of TRPV channels: unveiling a functionally diverse group of ion channels. Protein Science : a Publication of the Protein Society. PMID 32232875 DOI: 10.1002/pro.3861   
2020 Benítez-Angeles M, Morales-Lázaro SL, Juárez-González E, Rosenbaum T. TRPV1: Structure, Endogenous Agonists, and Mechanisms. International Journal of Molecular Sciences. 21. PMID 32408609 DOI: 10.3390/ijms21103421   
2020 Wang ZJ, Blanco I, Hayoz S, Brelidze TI. The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms. The Journal of Biological Chemistry. PMID 32341127 DOI: 10.1074/jbc.RA120.013281   
2020 Feigenspan A, Ohs A, von Wittgenstein J, Brandstätter JH, Babai N. Analysis of tetrodotoxin-sensitive sodium and low voltage-activated calcium channels in developing mouse retinal horizontal cells. Experimental Eye Research. 195: 108028. PMID 32277973 DOI: 10.1016/j.exer.2020.108028   
2020 Kanzaki Y, Fujita H, Sato K, Hosokawa M, Matsumae H, Shiraga F, Morizane Y, Ohuchi H. KCNJ13 Gene Deletion Impairs Cell Alignment and Phagocytosis in Retinal Pigment Epithelium Derived from Human-Induced Pluripotent Stem Cells. Investigative Ophthalmology & Visual Science. 61: 38. PMID 32437550 DOI: 10.1167/iovs.61.5.38   
2020 Brewer KR, Kuenze G, Vanoye CG, George AL, Meiler J, Sanders CR. Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome. Frontiers in Pharmacology. 11: 550. PMID 32431610 DOI: 10.3389/fphar.2020.00550   
2020 Islam MR, Okada T, Merzlyak PG, Toychiev AH, Ando-Akatsuka Y, Sabirov RZ, Okada Y. Annexin A2-S100A10 Represents the Regulatory Component of Maxi-Cl Channel Dependent on Protein Tyrosine Dephosphorylation and Intracellular Ca²⁺. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 54: 538-555. PMID 32442363 DOI: 10.33594/000000238   
2020 Zhu C, Lin R, Liu C, Huang M, Lin F, Zhang G, Zhang Y, Miao J, Lin W, Huang H. The Antagonism of 5-HT6 Receptor Attenuates Current-Induced Spikes and Improves Long-Term Potentiation the Regulation of M-Currents in a Pilocarpine-Induced Epilepsy Model. Frontiers in Pharmacology. 11: 475. PMID 32425770 DOI: 10.3389/fphar.2020.00475   
2020 Nowak MB, Greer-Short A, Wan X, Wu X, Deschênes I, Weinberg SH, Poelzing S. Intercellular Sodium Regulates Repolarization in Cardiac Tissue with Sodium Channel Gain of Function. Biophysical Journal. PMID 32402243 DOI: 10.1016/j.bpj.2020.04.014   
2020 Rockman ME, Vouga AG, Rothberg BS. Molecular mechanism of BK channel activation by the smooth muscle relaxant NS11021. The Journal of General Physiology. 152. PMID 32221543 DOI: 10.1085/jgp.201912506   
2020 Leisle L, Xu Y, Fortea E, Lee S, Galpin JD, Vien M, Ahern CA, Accardi A, Bernèche S. Divergent Cland H pathways underlie transport coupling and gating in CLC exchangers and channels. Elife. 9. PMID 32343228 DOI: 10.7554/eLife.51224   
2020 Chambers L, Dorrance AM. Regulation of ion channels in the microcirculation by mineralocorticoid receptor activation. Current Topics in Membranes. 85: 151-185. PMID 32402638 DOI: 10.1016/bs.ctm.2020.02.001   
2020 Liu CH, Seo R, Ho TS, Stankewich M, Mohler PJ, Hund TJ, Noebels JL, Rasband MN. β spectrin-dependent and domain specific mechanisms for Na channel clustering. Elife. 9. PMID 32425157 DOI: 10.7554/eLife.56629   
2020 Zhang DM, Lin YF. Functional Modulation of Sarcolemmal K Channels by Atrial Natriuretic Peptide-Elicited Intracellular Signaling in Adult Rabbit Ventricular Cardiomyocytes. American Journal of Physiology. Cell Physiology. PMID 32432931 DOI: 10.1152/ajpcell.00409.2019   
2020 Finol-Urdaneta RK, Belovanovic A, Micic-Vicovac M, Kinsella GK, McArthur JR, Al-Sabi A. Marine Toxins Targeting Kv1 Channels: Pharmacological Tools and Therapeutic Scaffolds. Marine Drugs. 18. PMID 32245015 DOI: 10.3390/md18030173