| Year |
Citation |
Score |
| 2020 |
Kok BP, Ghimire S, Kim W, Chatterjee S, Johns T, Kitamura S, Eberhardt J, Ogasawara D, Xu J, Sukiasyan A, Kim SM, Godio C, Bittencourt JM, Cameron M, Galmozzi A, ... ... Saez E, et al. Discovery of small-molecule enzyme activators by activity-based protein profiling. Nature Chemical Biology. PMID 32514184 DOI: 10.1038/S41589-020-0555-4 |
0.343 |
|
| 2020 |
Erikci Ertunc M, Kok BP, Parsons WH, Wang JG, Tan D, Donaldson CJ, Pinto AFM, Vaughan JM, Ngo N, Lum KM, Henry CL, Coppola AR, Niphakis MJ, Cravatt BF, Saez E, et al. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice. The Journal of Biological Chemistry. PMID 32152231 DOI: 10.1074/Jbc.Ra119.012145 |
0.387 |
|
| 2020 |
Ertunc ME, Kok BP, Parsons WH, Wang JG, Tan D, Donaldson CJ, Pinto AM, Vaughan JM, Ngo N, Lum KM, Henry CL, Coppola AR, Niphakis MJ, Cravatt BF, Saez E, et al. Role of AIG1 and ADTRP in Endogenous FAHFA Regulation The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04337 |
0.302 |
|
| 2019 |
Cintron-Colon R, Johnson CW, Montenegro-Burke JR, Guijas C, Faulhaber L, Sanchez-Alavez M, Aguirre CA, Shankar K, Singh M, Galmozzi A, Siuzdak G, Saez E, Conti B. Activation of Kappa Opioid Receptor Regulates the Hypothermic Response to Calorie Restriction and Limits Body Weight Loss. Current Biology : Cb. PMID 31786059 DOI: 10.1016/J.Cub.2019.10.027 |
0.305 |
|
| 2019 |
Galmozzi A, Kok BP, Kim AS, Montenegro-Burke JR, Lee JY, Spreafico R, Mosure S, Albert V, Cintron-Colon R, Godio C, Webb WR, Conti B, Solt LA, Kojetin D, Parker CG, ... ... Saez E, et al. PGRMC2 is an intracellular haem chaperone critical for adipocyte function. Nature. PMID 31748741 DOI: 10.1038/S41586-019-1774-2 |
0.418 |
|
| 2018 |
Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR, Metallo CM, Sander M. Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function. Cell Reports. 25: 2904-2918.e8. PMID 30517875 DOI: 10.1016/J.Celrep.2018.11.031 |
0.327 |
|
| 2018 |
Kok BP, Galmozzi A, Littlejohn NK, Albert V, Godio C, Kim W, Kim SM, Bland JS, Grayson N, Fang M, Meyerhof W, Siuzdak G, Srinivasan S, Behrens M, Saez E. Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits. Molecular Metabolism. PMID 30120064 DOI: 10.1016/J.Molmet.2018.07.013 |
0.334 |
|
| 2018 |
Galmozzi A, Parker CG, Kok BP, Cravatt BF, Saez E. Discovery of Modulators of Adipocyte Physiology Using Fully Functionalized Fragments. Methods in Molecular Biology (Clifton, N.J.). 1787: 115-127. PMID 29736714 DOI: 10.1007/978-1-4939-7847-2_9 |
0.365 |
|
| 2018 |
Audano M, Pedretti S, Cermenati G, Brioschi E, Diaferia GR, Ghisletti S, Cuomo A, Bonaldi T, Salerno F, Mora M, Grigore L, Garlaschelli K, Baragetti A, Bonacina F, Catapano AL, ... ... Saez E, et al. Zc3h10 is a novel mitochondrial regulator. Embo Reports. 19. PMID 29507079 DOI: 10.15252/Embr.201745531 |
0.314 |
|
| 2017 |
Parker CG, Kuttruff CA, Galmozzi A, Jørgensen L, Yeh CH, Hermanson DJ, Wang Y, Artola M, McKerrall SJ, Josyln CM, Nørremark B, Dünstl G, Felding J, Saez E, Baran PS, et al. Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs. Acs Central Science. 3: 1276-1285. PMID 29296668 DOI: 10.1021/Acscentsci.7B00420 |
0.333 |
|
| 2017 |
Beyer BA, Fang M, Sadrian B, Montenegro-Burke JR, Plaisted WC, Kok BPC, Saez E, Kondo T, Siuzdak G, Lairson LL. Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation. Nature Chemical Biology. PMID 29131145 DOI: 10.1038/Nchembio.2517 |
0.328 |
|
| 2017 |
Finlin BS, Zhu B, Kok BP, Godio C, Westgate PM, Grayson N, Sims R, Bland JS, Saez E, Kern PA. The Influence of a KDT501, a Novel Isohumulone, on Adipocyte Function in Humans. Frontiers in Endocrinology. 8: 255. PMID 29033896 DOI: 10.3389/Fendo.2017.00255 |
0.304 |
|
| 2017 |
Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, ... ... Saez E, et al. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. PMID 28965760 DOI: 10.1016/J.Cell.2017.08.051 |
0.336 |
|
| 2017 |
Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S, Reue K, Young SG, Whitelegge J, Saez E, Black DL, et al. RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs. The Journal of Clinical Investigation. PMID 28192372 DOI: 10.1172/Jci89484 |
0.525 |
|
| 2017 |
Parker CG, Galmozzi A, Wang Y, Correia BE, Sasaki K, Joslyn CM, Kim AS, Cavallaro CL, Lawrence RM, Johnson SR, Narvaiza I, Saez E, Cravatt BF. Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. PMID 28111073 DOI: 10.1016/J.Cell.2016.12.029 |
0.304 |
|
| 2016 |
Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, et al. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding-site Tyr Residue. Journal of the American Chemical Society. PMID 27191344 DOI: 10.1021/Jacs.6B02960 |
0.318 |
|
| 2016 |
Parsons WH, Kolar MJ, Kamat SS, Iii AB, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nature Chemical Biology. PMID 27018888 DOI: 10.1038/Nchembio.2051 |
0.309 |
|
| 2016 |
Ceperuelo-Mallafré V, Ejarque M, Serena C, Duran X, Montori-Grau M, Rodríguez MA, Yanes O, Núñez-Roa C, Roche K, Puthanveetil P, Garrido-Sánchez L, Saez E, Tinahones FJ, Garcia-Roves PM, Gómez-Foix AM, et al. Adipose tissue glycogen accumulation is associated with obesity-linked inflammation in humans. Molecular Metabolism. 5: 5-18. PMID 26844203 DOI: 10.1016/J.Molmet.2015.10.001 |
0.326 |
|
| 2015 |
Mitro N, Cermenati G, Audano M, Giatti S, D'Antonio M, Fabiani ED, Crestani M, Saez E, Azcoitia I, Cavaletti G, Garcia-Segura LM, Melcangi RC, Caruso D. The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function. Springerplus. 4: L45. PMID 27386207 DOI: 10.1186/2193-1801-4-S1-L45 |
0.328 |
|
| 2015 |
Cermenati G, Audano M, Giatti S, Carozzi V, Porretta-Serapiglia C, Pettinato E, Ferri C, D'Antonio M, De Fabiani E, Crestani M, Scurati S, Saez E, Azcoitia I, Cavaletti G, Garcia-Segura LM, et al. Lack of sterol regulatory element binding factor-1c imposes glial Fatty Acid utilization leading to peripheral neuropathy. Cell Metabolism. 21: 571-83. PMID 25817536 DOI: 10.1016/J.Cmet.2015.02.016 |
0.321 |
|
| 2014 |
Galmozzi A, Sonne SB, Altshuler-Keylin S, Hasegawa Y, Shinoda K, Luijten IH, Chang JW, Sharp LZ, Cravatt BF, Saez E, Kajimura S. ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue. Cell Reports. 9: 1584-93. PMID 25466254 DOI: 10.1016/J.Celrep.2014.10.066 |
0.598 |
|
| 2014 |
Kok BP, Saez E. Activating PI3-kinase to dampen inflammation. Chemistry & Biology. 21: 917-8. PMID 25126986 DOI: 10.1016/J.Chembiol.2014.07.012 |
0.321 |
|
| 2014 |
Galmozzi A, Dominguez E, Cravatt BF, Saez E. Application of activity-based protein profiling to study enzyme function in adipocytes. Methods in Enzymology. 538: 151-69. PMID 24529438 DOI: 10.1016/B978-0-12-800280-3.00009-8 |
0.32 |
|
| 2014 |
Dominguez E, Galmozzi A, Chang JW, Hsu KL, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O'Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, ... Saez E, et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nature Chemical Biology. 10: 113-21. PMID 24362705 DOI: 10.1038/Nchembio.1429 |
0.343 |
|
| 2013 |
Chou WL, Galmozzi A, Partida D, Kwan K, Yeung H, Su AI, Saez E. Identification of regulatory elements that control PPARγ expression in adipocyte progenitors. Plos One. 8: e72511. PMID 24009687 DOI: 10.1371/Journal.Pone.0072511 |
0.407 |
|
| 2013 |
Sanchez-Alavez M, Conti B, Wood MR, Bortell N, Bustamante E, Saez E, Fox HS, Marcondes MC. ROS and Sympathetically Mediated Mitochondria Activation in Brown Adipose Tissue Contribute to Methamphetamine-Induced Hyperthermia. Frontiers in Endocrinology. 4: 44. PMID 23630518 DOI: 10.3389/Fendo.2013.00044 |
0.343 |
|
| 2013 |
Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, et al. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metabolism. 17: 423-35. PMID 23473036 DOI: 10.1016/J.Cmet.2013.01.016 |
0.574 |
|
| 2013 |
Galmozzi A, Mitro N, Ferrari A, Gers E, Gilardi F, Godio C, Cermenati G, Gualerzi A, Donetti E, Rotili D, Valente S, Guerrini U, Caruso D, Mai A, Saez E, et al. Inhibition of class i histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue Diabetes. 62: 732-742. PMID 23069623 DOI: 10.2337/Db12-0548 |
0.349 |
|
| 2011 |
Villanueva CJ, Waki H, Godio C, Nielsen R, Chou WL, Vargas L, Wroblewski K, Schmedt C, Chao LC, Boyadjian R, Mandrup S, Hevener A, Saez E, Tontonoz P. TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metabolism. 13: 413-27. PMID 21459326 DOI: 10.1016/J.Cmet.2011.02.014 |
0.584 |
|
| 2010 |
Cermenati G, Giatti S, Cavaletti G, Bianchi R, Maschi O, Pesaresi M, Abbiati F, Volonterio A, Saez E, Caruso D, Melcangi RC, Mitro N. Activation of the liver X receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11896-901. PMID 20826654 DOI: 10.1523/Jneurosci.1898-10.2010 |
0.343 |
|
| 2010 |
Teo H, Ghosh S, Luesch H, Ghosh A, Wong ET, Malik N, Orth A, de Jesus P, Perry AS, Oliver JD, Tran NL, Speiser LJ, Wong M, Saez E, Schultz P, et al. Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nature Cell Biology. 12: 758-67. PMID 20622870 DOI: 10.1038/Ncb2080 |
0.319 |
|
| 2010 |
Zhu J, Mounzih K, Chehab EF, Mitro N, Saez E, Chehab FF. Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake. Journal of Lipid Research. 51: 1312-24. PMID 20037138 DOI: 10.1194/Jlr.M001586 |
0.424 |
|
| 2010 |
Epple R, Cow C, Xie Y, Azimioara M, Russo R, Wang X, Wityak J, Karanewsky DS, Tuntland T, Nguyêñ-Trân VT, Cuc Ngo C, Huang D, Saez E, Spalding T, Gerken A, et al. Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists. Journal of Medicinal Chemistry. 53: 77-105. PMID 19928766 DOI: 10.1021/Jm9007399 |
0.366 |
|
| 2008 |
Wu C, Delano DL, Mitro N, Su SV, Janes J, McClurg P, Batalov S, Welch GL, Zhang J, Orth AP, Walker JR, Glynne RJ, Cooke MP, Takahashi JS, Shimomura K, ... ... Saez E, et al. Gene set enrichment in eQTL data identifies novel annotations and pathway regulators. Plos Genetics. 4: e1000070. PMID 18464898 DOI: 10.1371/Journal.Pgen.1000070 |
0.386 |
|
| 2007 |
Commerford SR, Vargas L, Dorfman SE, Mitro N, Rocheford EC, Mak PA, Li X, Kennedy P, Mullarkey TL, Saez E. Dissection of the insulin-sensitizing effect of liver X receptor ligands. Molecular Endocrinology (Baltimore, Md.). 21: 3002-12. PMID 17717069 DOI: 10.1210/Me.2007-0156 |
0.369 |
|
| 2007 |
Molteni V, Li X, Nabakka J, Liang F, Wityak J, Koder A, Vargas L, Romeo R, Mitro N, Mak PA, Seidel HM, Haslam JA, Chow D, Tuntland T, Spalding TA, ... ... Saez E, et al. N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta. Journal of Medicinal Chemistry. 50: 4255-9. PMID 17665897 DOI: 10.1021/Jm070453F |
0.539 |
|
| 2007 |
Waki H, Park KW, Mitro N, Pei L, Damoiseaux R, Wilpitz DC, Reue K, Saez E, Tontonoz P. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metabolism. 5: 357-70. PMID 17488638 DOI: 10.1016/J.Cmet.2007.03.010 |
0.597 |
|
| 2007 |
Mitro N, Vargas L, Romeo R, Koder A, Saez E. T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR. Febs Letters. 581: 1721-6. PMID 17418145 DOI: 10.1016/J.Febslet.2007.03.047 |
0.371 |
|
| 2007 |
Mitro N, Mak PA, Vargas L, Godio C, Hampton E, Molteni V, Kreusch A, Saez E. The nuclear receptor LXR is a glucose sensor. Nature. 445: 219-23. PMID 17187055 DOI: 10.1038/Nature05449 |
0.369 |
|
| 2006 |
Epple R, Azimioara M, Russo R, Xie Y, Wang X, Cow C, Wityak J, Karanewsky D, Bursulaya B, Kreusch A, Tuntland T, Gerken A, Iskandar M, Saez E, Martin Seidel H, et al. 3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists. Part 2. Bioorganic & Medicinal Chemistry Letters. 16: 5488-92. PMID 16931011 DOI: 10.1016/J.Bmcl.2006.08.052 |
0.355 |
|
| 2006 |
Cho CY, Koo SH, Wang Y, Callaway S, Hedrick S, Mak PA, Orth AP, Peters EC, Saez E, Montminy M, Schultz PG, Chanda SK. Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. Cell Metabolism. 3: 367-78. PMID 16679294 DOI: 10.1016/J.Cmet.2006.03.006 |
0.337 |
|
| 2005 |
Galimi F, Saez E, Gall J, Hoong N, Cho G, Evans RM, Verma IM. Development of ecdysone-regulated lentiviral vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 142-8. PMID 15585415 DOI: 10.1016/J.Ymthe.2004.08.021 |
0.385 |
|
| 2004 |
Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, Pei L, Hogenesch J, O'connell RM, Cheng G, Saez E, Miller JF, Tontonoz P. LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell. 119: 299-309. PMID 15479645 DOI: 10.1016/J.Cell.2004.09.032 |
0.569 |
|
| 2004 |
Saez E, Rosenfeld J, Livolsi A, Olson P, Lombardo E, Nelson M, Banayo E, Cardiff RD, Izpisua-Belmonte JC, Evans RM. PPAR gamma signaling exacerbates mammary gland tumor development. Genes & Development. 18: 528-40. PMID 15037548 DOI: 10.1101/Gad.1167804 |
0.336 |
|
| 2003 |
Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, Castrillo A, Wilpitz DC, Mangelsdorf DJ, Collins JL, Saez E, Tontonoz P. Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proceedings of the National Academy of Sciences of the United States of America. 100: 5419-24. PMID 12697904 DOI: 10.1073/Pnas.0830671100 |
0.58 |
|
| 2000 |
Saez E, Nelson MC, Eshelman B, Banayo E, Koder A, Cho GJ, Evans RM. Identification of ligands and coligands for the ecdysone-regulated gene switch. Proceedings of the National Academy of Sciences of the United States of America. 97: 14512-7. PMID 11114195 DOI: 10.1073/Pnas.260499497 |
0.399 |
|
| 2000 |
Chawla A, Saez E, Evans RM. "Don't know much bile-ology". Cell. 103: 1-4. PMID 11051540 DOI: 10.1016/S0092-8674(00)00097-0 |
0.351 |
|
| 1998 |
Saez E, Tontonoz P, Nelson MC, Alvarez JG, Ming UT, Baird SM, Thomazy VA, Evans RM. Activators of the nuclear receptor PPARgamma enhance colon polyp formation. Nature Medicine. 4: 1058-61. PMID 9734400 DOI: 10.1038/2042 |
0.568 |
|
| 1998 |
Serova LI, Saez E, Spiegelman BM, Sabban EL. c-Fos deficiency inhibits induction of mRNA for some, but not all, neurotransmitter biosynthetic enzymes by immobilization stress Journal of Neurochemistry. 70: 1935-1940. PMID 9572277 DOI: 10.1046/J.1471-4159.1998.70051935.X |
0.512 |
|
| 1998 |
Sabban EL, Nankova BB, Serova LI, Hiremagalur B, Rusnak M, Saez E, Spiegelman B, Kvetnanský R. Regulation of gene expression of catecholamine biosynthetic enzymes by stress. Advances in Pharmacology (San Diego, Calif.). 42: 564-7. PMID 9327964 DOI: 10.1016/S1054-3589(08)60813-3 |
0.523 |
|
| 1997 |
Rutberg SE, Saez E, Lo S, Jang SI, Markova N, Spiegelman BM, Yuspa SH. Opposing activities of c-Fos and Fra-2 on AP-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters. Oncogene. 15: 1337-46. PMID 9315102 DOI: 10.1038/Sj.Onc.1201293 |
0.342 |
|
| 1995 |
Saez E, Rutberg SE, Mueller E, Oppenheim H, Smoluk J, Yuspa SH, Spiegelman BM. c-fos is required for malignant progression of skin tumors. Cell. 82: 721-32. PMID 7545543 DOI: 10.1016/0092-8674(95)90469-7 |
0.484 |
|
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