Michael Tymianski, M.D., Ph.D. - Publications

Neurosurgery Toronto Western Hospital, University of Toronto 
Stroke, NMDA receptors, TRP channels

142 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Teves LM, Cui H, Tymianski M. Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26661213 DOI: 10.1177/0271678X15612099  1
2015 Horne MA, Flemming KD, Su IC, Stapf C, Jeon JP, Li D, Maxwell SS, White P, Christianson TJ, Agid R, Cho WS, Oh CW, Wu Z, Zhang JT, Kim JE, et al. Clinical course of untreated cerebral cavernous malformations: a meta-analysis of individual patient data. The Lancet. Neurology. PMID 26654287 DOI: 10.1016/S1474-4422(15)00303-8  1
2015 Xu B, Xiao AJ, Chen W, Turlova E, Liu R, Barszczyk A, Sun CL, Liu L, Tymianski M, Feng ZP, Sun HS. Neuroprotective Effects of a PSD-95 Inhibitor in Neonatal Hypoxic-Ischemic Brain Injury. Molecular Neurobiology. PMID 26520452 DOI: 10.1007/s12035-015-9488-4  1
2015 Wong JH, Tymianski R, Radovanovic I, Tymianski M. Minimally Invasive Microsurgery for Cerebral Aneurysms. Stroke; a Journal of Cerebral Circulation. 46: 2699-706. PMID 26304867 DOI: 10.1161/STROKEAHA.115.008221  1
2015 Shabanzadeh AP, Tassew NG, Szydlowska K, Tymianski M, Banerjee P, Vigouroux RJ, Eubanks JH, Huang L, Geraerts M, Koeberle PD, Mueller BK, Monnier PP. Uncoupling Neogenin association with lipid rafts promotes neuronal survival and functional recovery after stroke. Cell Death & Disease. 6: e1744. PMID 25950474 DOI: 10.1038/cddis.2015.109  1
2015 Saliou G, Sacho RH, Power S, Kostynskyy A, Willinsky RA, Tymianski M, terBrugge KG, Rawal S, Krings T. Natural history and management of basilar trunk artery aneurysms. Stroke; a Journal of Cerebral Circulation. 46: 948-53. PMID 25712945 DOI: 10.1161/STROKEAHA.114.006909  1
2015 Sam K, Poublanc J, Sobczyk O, Han JS, Battisti-Charbonney A, Mandell DM, Tymianski M, Crawley AP, Fisher JA, Mikulis DJ. Assessing the effect of unilateral cerebral revascularisation on the vascular reactivity of the non-intervened hemisphere: a retrospective observational study. Bmj Open. 5: e006014. PMID 25673438 DOI: 10.1136/bmjopen-2014-006014  1
2015 da Costa L, Houlden D, Rubenfeld G, Tymianski M, Fisher J, Fierstra J. Impaired cerebrovascular reactivity in the early phase of subarachnoid hemorrhage in good clinical grade patients does not predict vasospasm. Acta Neurochirurgica. Supplement. 120: 249-53. PMID 25366632 DOI: 10.1007/978-3-319-04981-6_42  1
2015 da Costa L, Fisher J, Mikulis DJ, Tymianski M, Fierstra J. Early identification of brain tissue at risk for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Acta Neurochirurgica. Supplement. 120: 105-9. PMID 25366608 DOI: 10.1007/978-3-319-04981-6_18  1
2015 Wong J, Radovanovic I, Tymianski M. The impact of ARUBA on the management of unruptured brain arteriovenous malformations: Review of literature Japanese Journal of Neurosurgery. 24: 605-613. DOI: 10.7887/jcns.24.605  1
2015 Tymianski M. Neuroprotective therapies: Preclinical reproducibility is only part of the problem Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aac9412  1
2015 Zweifel C, Sacho RH, Tymianski R, Radovanovic I, Tymianski M. Safety, efficacy, and cost of surgery for patients with unruptured aneurysms deemed unsuitable for endovascular therapy Acta Neurochirurgica. 157: 2061-2070. DOI: 10.1007/s00701-015-2606-2  1
2015 Belkhair S, Maldonado AG, Tymianski M, Radovanovic I. Neurosurgery for Intracranial and Spinal Cavernomas Panvascular Medicine, Second Edition. 2855-2875. DOI: 10.1007/978-3-642-37078-6_102  1
2014 Sacho RH, Saliou G, Kostynskyy A, Menezes R, Tymianski M, Krings T, Radovanovic I, Terbrugge K, Rinkel GJ, Willinsky R. Natural history and outcome after treatment of unruptured intradural fusiform aneurysms. Stroke; a Journal of Cerebral Circulation. 45: 3251-6. PMID 25205312 DOI: 10.1161/STROKEAHA.114.006292  1
2014 Goettel N, Ghosh J, Tymianski M, Manninen PH. Postoperative visual loss following cerebral arteriovenous malformation surgery: a case report. F1000research. 3: 27. PMID 24627798 DOI: 10.12688/f1000research.3-27.v2  1
2014 Song JN, Zhang M, Li DD, Li M, An JY, Cheng MF, Guo XY. Dynamic expression of the suppressor of cytokine signaling-3 and cytokines in the cerebral basilar artery of rats with subarachnoid hemorrhage, and the effect of acetylcholine. Acta Neurochirurgica. 156: 941-9; discussion 94. PMID 24463741 DOI: 10.1007/s00701-014-1998-8  1
2014 Radovanovic I, Abou-Hamden A, Bacigaluppi S, Tymianski M. A safety, length of stay, and cost analysis of minimally invasive microsurgery for anterior circulation aneurysms Acta Neurochirurgica. 156: 493-503. PMID 24395051 DOI: 10.1007/s00701-013-1980-x  1
2014 Tymianski M. Stroke in 2013: Disappointments and advances in acute stroke intervention Nature Reviews Neurology. 10: 66-68. PMID 24394291 DOI: 10.1038/nrneurol.2013.271  1
2014 da Costa L, Fierstra J, Fisher JA, Mikulis DJ, Han JS, Tymianski M. BOLD MRI and early impairment of cerebrovascular reserve after aneurysmal subarachnoid hemorrhage. Journal of Magnetic Resonance Imaging : Jmri. 40: 972-9. PMID 24243534 DOI: 10.1002/jmri.24474  1
2014 Rawal S, Croul SE, Willinsky RA, Tymianski M, Krings T. Subcortical cystic lesions within the anterior superior temporal gyrus: a newly recognized characteristic location for dilated perivascular spaces. Ajnr. American Journal of Neuroradiology. 35: 317-22. PMID 23945225 DOI: 10.3174/ajnr.A3669  1
2014 Boulos MI, Lena S, Han J, Mikulis D, Tymianski M, Jaigobin C, Wennberg R. Novel EEG pattern associated with impaired cerebrovascular reserve in Moyamoya disease Clinical Neurophysiology. 125: 422-425. PMID 23871179 DOI: 10.1016/j.clinph.2013.06.026  1
2014 Goettel N, Chui J, Venkatraghavan L, Tymianski M, Manninen PH. Day surgery craniotomy for unruptured cerebral aneurysms: A single center experience Journal of Neurosurgical Anesthesiology. 26: 60-64. PMID 23715046 DOI: 10.1097/ANA.0b013e3182991d8b  1
2014 Goyal M, Tymianski M. Bottlenecks in acute stroke care and research : Solutions and innovations Stroke. 45: 6-7. DOI: 10.1161/STROKEAHA.113.003965  1
2014 Cook DJ, Tymianski M. Treatment of stroke The Behavioral Consequences of Stroke. 2147483647: 15-35. DOI: 10.1007/978-1-4614-7672-6_2  1
2013 Alim I, Teves L, Li R, Mori Y, Tymianski M. Modulation of NMDAR subunit expression by TRPM2 channels regulates neuronal vulnerability to ischemic cell death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 17264-77. PMID 24174660 DOI: 10.1523/JNEUROSCI.1729-13.2013  1
2013 Tymianski M. Novel approaches to neuroprotection trials in acute ischemic stroke Stroke. 44: 2942-2950. PMID 24021680 DOI: 10.1161/STROKEAHA.113.000731  1
2013 Ibrahim GM, Tymianski M, Bernstein M. Priority setting in neurosurgery as exemplified by an everyday challenge The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 40: 378-383. PMID 23603175  1
2013 Lanzino G, Burrows AM, Tymianski M. Advances in stroke: Vascular neurosurgery Stroke. 44: 316-317. PMID 23321447 DOI: 10.1161/STROKEAHA.111.000385  1
2012 Hill MD, Martin RH, Mikulis D, Wong JH, Silver FL, Terbrugge KG, Milot G, Clark WM, Macdonald RL, Kelly ME, Boulton M, Fleetwood I, McDougall C, Gunnarsson T, Chow M, ... ... Tymianski M, et al. Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial. The Lancet. Neurology. 11: 942-50. PMID 23051991 DOI: 10.1016/S1474-4422(12)70225-9  1
2012 Cook DJ, Teves L, Tymianski M. A translational paradigm for the preclinical evaluation of the stroke neuroprotectant Tat-NR2B9c in gyrencephalic nonhuman primates Science Translational Medicine. 4. PMID 23035045 DOI: 10.1126/scitranslmed.3003824  1
2012 Cook DJ, Tymianski M. Nonhuman Primate Models of Stroke for Translational Neuroprotection Research Neurotherapeutics. 9: 371-379. PMID 22437447 DOI: 10.1007/s13311-012-0115-z  1
2012 Cook DJ, Teves L, Tymianski M. Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain Nature. 483: 213-217. PMID 22388811 DOI: 10.1038/nature10841  1
2012 Thines L, Dehdashti AR, Da Costa L, Tymianski M, Ter Brugge KG, Willinsky RA, Schwartz M, Wallace MC. Challenges in the management of ruptured and unruptured brainstem arteriovenous malformations: Outcome after conservative, single-modality, or multimodality treatments Neurosurgery. 70: 155-161. PMID 21637136 DOI: 10.1227/NEU.0b013e31822670ac  1
2012 Fierstra J, Conklin J, Krings T, Slessarev M, Han JS, Fisher JA, Terbrugge K, Wallace MC, Tymianski M, Mikulis DJ. Reply: A comment on impaired peri-nidal cerebrovascular reserve in seizure patients with brain arteriovenous malformations Brain. 135: e198. DOI: 10.1093/brain/awr106  1
2012 Tymianski M. Acute perfusion changes after spontaneous SAH: A perfusion CT study - Commentary Acta Neurochirurgica. 154: 412. DOI: 10.1007/s00701-011-1267-z  1
2011 Xie YF, Belrose JC, Lei G, Tymianski M, Mori Y, Macdonald JF, Jackson MF. Dependence of NMDA/GSK-3β mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses. Molecular Brain. 4: 44. PMID 22188973 DOI: 10.1186/1756-6606-4-44  1
2011 Tymianski M. Emerging mechanisms of disrupted cellular signaling in brain ischemia Nature Neuroscience. 14: 1369-1373. PMID 22030547 DOI: 10.1038/nn.2951  1
2011 Ibrahim GM, Abou-Hamden A, Shankar JJ, Bharatha A, ter Brugge K, Tymianski M. Microsurgical glue embolectomy of the middle cerebral artery following embolization of a maxillofacial arteriovenous malformation. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 18: 1733-6. PMID 21985743 DOI: 10.1016/j.jocn.2011.04.020  1
2011 Tymianski M. Aspirin as a promising agent for decreasing incidence of cerebral aneurysm rupture Stroke. 42: 3003-3004. PMID 21980203 DOI: 10.1161/STROKEAHA.111.626762  1
2011 Krings T, Mandell DM, Kiehl TR, Geibprasert S, Tymianski M, Alvarez H, terBrugge KG, Hans FJ. Intracranial aneurysms: from vessel wall pathology to therapeutic approach. Nature Reviews. Neurology. 7: 547-59. PMID 21931350 DOI: 10.1038/nrneurol.2011.136  1
2011 Bråtane BT, Cui H, Cook DJ, Bouley J, Tymianski M, Fisher M. Neuroprotection by freezing ischemic penumbra evolution without cerebral blood flow augmentation with a postsynaptic density-95 protein inhibitor. Stroke; a Journal of Cerebral Circulation. 42: 3265-70. PMID 21903963 DOI: 10.1161/STROKEAHA.111.618801  1
2011 Han JS, Abou-Hamden A, Mandell DM, Poublanc J, Crawley AP, Fisher JA, Mikulis DJ, Tymianski M. Impact of extracranial-intracranial bypass on cerebrovascular reactivity and clinical outcome in patients with symptomatic moyamoya vasculopathy. Stroke; a Journal of Cerebral Circulation. 42: 3047-54. PMID 21903951 DOI: 10.1161/STROKEAHA.111.615955  1
2011 Fierstra J, Spieth S, Tran L, Conklin J, Tymianski M, ter Brugge KG, Fisher JA, Mikulis DJ, Krings T. Severely impaired cerebrovascular reserve in patients with cerebral proliferative angiopathy. Journal of Neurosurgery. Pediatrics. 8: 310-5. PMID 21882924 DOI: 10.3171/2011.6.PEDS1170  1
2011 Conklin J, Fierstra J, Crawley AP, Han JS, Poublanc J, Silver FL, Tymianski M, Fisher JA, Mandell DM, Mikulis DJ. Mapping white matter diffusion and cerebrovascular reactivity in carotid occlusive disease. Neurology. 77: 431-8. PMID 21775744 DOI: 10.1212/WNL.0b013e318227b1e7  1
2011 Monnier PP, D'Onofrio PM, Magharious M, Hollander AC, Tassew N, Szydlowska K, Tymianski M, Koeberle PD. Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10494-505. PMID 21775595 DOI: 10.1523/JNEUROSCI.0148-11.2011  1
2011 Cook DJ, Tymianski M. Translating promising preclinical neuroprotective therapies to human stroke trials Expert Review of Cardiovascular Therapy. 9: 433-449. PMID 21517728 DOI: 10.1586/erc.11.34  1
2011 Fierstra J, Maclean DB, Fisher JA, Han JS, Mandell DM, Conklin J, Poublanc J, Crawley AP, Regli L, Mikulis DJ, Tymianski M. Surgical revascularization reverses cerebral cortical thinning in patients with severe cerebrovascular steno-occlusive disease. Stroke; a Journal of Cerebral Circulation. 42: 1631-7. PMID 21493908 DOI: 10.1161/STROKEAHA.110.608521  1
2011 Mandell DM, Han JS, Poublanc J, Crawley AP, Fierstra J, Tymianski M, Fisher JA, Mikulis DJ. Quantitative measurement of cerebrovascular reactivity by blood oxygen level-dependent MR imaging in patients with intracranial stenosis: preoperative cerebrovascular reactivity predicts the effect of extracranial-intracranial bypass surgery. Ajnr. American Journal of Neuroradiology. 32: 721-7. PMID 21436343 DOI: 10.3174/ajnr.A2365  1
2011 Chen DQ, Quan J, Guha A, Tymianski M, Mikulis D, Hodaie M. Three-dimensional in vivo modeling of vestibular schwannomas and surrounding cranial nerves with diffusion imaging tractography Neurosurgery. 68: 1077-1083. PMID 21242825 DOI: 10.1227/NEU.0b013e31820c6cbe  1
2011 Lanzino G, D'Urso PI, Tymianski M. Advances in vascular neurosurgery 2010 Stroke. 42: 288-290. PMID 21233465 DOI: 10.1161/STROKEAHA.110.605105  1
2011 Fierstra J, Conklin J, Krings T, Slessarev M, Han JS, Fisher JA, Terbrugge K, Wallace MC, Tymianski M, Mikulis DJ. Impaired peri-nidal cerebrovascular reserve in seizure patients with brain arteriovenous malformations. Brain : a Journal of Neurology. 134: 100-9. PMID 21109501 DOI: 10.1093/brain/awq286  1
2011 Songsaeng D, Geibprasert S, Ter Brugge KG, Willinsky R, Tymianski M, Krings T. Impact of individual intracranial arterial aneurysm morphology on initial obliteration and recurrence rates of endovascular treatments: A multivariate analysis - Clinical article Journal of Neurosurgery. 114: 994-1002. PMID 20932093 DOI: 10.3171/2010.8.JNS10241  1
2010 Songsaeng D, Geibprasert S, Willinsky R, Tymianski M, Terbrugge KG, Krings T. Impact of anatomical variations of the circle of Willis on the incidence of aneurysms and their recurrence rate following endovascular treatment Clinical Radiology. 65: 895-901. PMID 20933644 DOI: 10.1016/j.crad.2010.06.010  1
2010 Tymianski M. Can molecular and cellular neuroprotection be translated into therapies for patients?: Yes, but not the way we tried it before Stroke. 41: S87-S90. PMID 20876514 DOI: 10.1161/STROKEAHA.110.595496  1
2010 Thines L, Dehdashti AR, Howard P, Costa LD, Wallace MC, Willinsky RA, Tymianski M, Lejeune JP, Agid R. Postoperative assessment of clipped aneurysms with 64-slice computerized tomography angiography Neurosurgery. 67: 844-853. PMID 20657317 DOI: 10.1227/01.NEU.0000374684.10920.A2  1
2010 Schatlo B, Dreier JP, Gläsker S, Fathi AR, Moncrief T, Oldfield EH, Vortmeyer AO, Pluta RM. Report of selective cortical infarcts in the primate clot model of vasospasm after subarachnoid hemorrhage. Neurosurgery. 67: 721-8; discussion 72. PMID 20651629 DOI: 10.1227/01.NEU.0000378024.70848.8F  1
2010 Conklin J, Fierstra J, Crawley AP, Han JS, Poublanc J, Mandell DM, Silver FL, Tymianski M, Fisher JA, Mikulis DJ. Impaired cerebrovascular reactivity with steal phenomenon is associated with increased diffusion in white matter of patients with Moyamoya disease. Stroke; a Journal of Cerebral Circulation. 41: 1610-6. PMID 20576954 DOI: 10.1161/STROKEAHA.110.579540  1
2010 Lau A, Tymianski M. Glutamate receptors, neurotoxicity and neurodegeneration Pflugers Archiv European Journal of Physiology. 460: 525-542. PMID 20229265 DOI: 10.1007/s00424-010-0809-1  1
2010 Fierstra J, Poublanc J, Han JS, Silver F, Tymianski M, Crawley AP, Fisher JA, Mikulis DJ. Steal physiology is spatially associated with cortical thinning Journal of Neurology, Neurosurgery and Psychiatry. 81: 290-293. PMID 20185465 DOI: 10.1136/jnnp.2009.188078  1
2010 Szydlowska K, Tymianski M. Calcium, ischemia and excitotoxicity Cell Calcium. 47: 122-129. PMID 20167368 DOI: 10.1016/j.ceca.2010.01.003  1
2010 Heyn C, Poublanc J, Crawley A, Mandell D, Han JS, Tymianski M, TerBrugge K, Fisher JA, Mikulis DJ. Quantification of cerebrovascular reactivity by blood oxygen level - Dependent MR imaging and correlation with conventional angiography in patients with moyamoya disease American Journal of Neuroradiology. 31: 862-867. PMID 20075092 DOI: 10.3174/ajnr.A1922  1
2010 Dehdashti AR, Thines L, Willinsky RA, terBrugge KG, Schwartz ML, Tymianski M, Wallace MC. Multidisciplinary care of occipital arteriovenous malformations: effect on nonhemorrhagic headache, vision, and outcome in a series of 135 patients. Clinical article. Journal of Neurosurgery. 113: 742-8. PMID 20059323 DOI: 10.3171/2009.11.JNS09884  1
2009 Sun HS, Jackson MF, Martin LJ, Jansen K, Teves L, Cui H, Kiyonaka S, Mori Y, Jones M, Forder JP, Golde TE, Orser BA, Macdonald JF, Tymianski M. Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nature Neuroscience. 12: 1300-7. PMID 19734892 DOI: 10.1038/nn.2395  1
2009 Tymianski M. International Stroke Conference 2009. Translation of High Impact Targets into Clinical Trials Idrugs. 12: 217-219. PMID 19350462  1
2009 Dehdashti AR, Thines L, Willinsky RA, Tymianski M. Symptomatic enlargement of an occluded giant carotido-ophthalmic aneurysm after endovascular treatment: The vasa vasorum theory Acta Neurochirurgica. 151: 1153-1158. PMID 19343269 DOI: 10.1007/s00701-009-0270-0  1
2009 Bacigaluppi S, Dehdashti AR, Agid R, Krings T, Tymianski M, Mikulis DJ. The contribution of imaging in diagnosis, preoperative assessment, and follow-up of moyamoya disease. A review Neurosurgical Focus. 26. PMID 19335129 DOI: 10.3171.2009.01.FOCUS08296  1
2009 Thines L, Agid R, Dehdashti AR, Da Costa L, Wallace MC, Terbrugge KG, Tymianski M. Assessment of extracranial-intracranial bypass patency with 64-slice multidetector computerized tomography angiography Neuroradiology. 51: 505-515. PMID 19308366 DOI: 10.1007/s00234-009-0522-y  1
2009 Dehdashti AR, Thines L, Da Costa LB, TerBrugge KG, Willinsky RA, Wallace MC, Tymianski M. Intraoperative biplanar rotational angiography during neurovascular surgery: Technical note Journal of Neurosurgery. 111: 188-192. PMID 19301971 DOI: 10.3171/2008.12.JNS081018  1
2009 Erlich SA, Tymianski M, Kiehl TR. Cellular schwannoma of the abducens nerve: case report and review of the literature. Clinical Neurology and Neurosurgery. 111: 467-71. PMID 19200646 DOI: 10.1016/j.clineuro.2009.01.001  1
2009 Olah ME, Jackson MF, Li H, Perez Y, Sun HS, Kiyonaka S, Mori Y, Tymianski M, MacDonald JF. Ca2+-dependent induction of TRPM2 currents in hippocampal neurons. The Journal of Physiology. 587: 965-79. PMID 19124544 DOI: 10.1113/jphysiol.2008.162289  1
2009 Dehdashti AR, Da Costa LB, TerBrugge KG, Willinsky RA, Tymianski M, Wallace MC. Overview of the current role of endovascular and surgical treatment in spinal dural arteriovenous fistulas Neurosurgical Focus. 26. PMID 19119894 DOI: 10.3171/FOC.2009.26.1.E8  1
2009 Forder JP, Tymianski M. Postsynaptic mechanisms of excitotoxicity: Involvement of postsynaptic density proteins, radicals, and oxidant molecules. Neuroscience. 158: 293-300. PMID 19041375 DOI: 10.1016/j.neuroscience.2008.10.021  1
2009 da Costa L, Thines L, Dehdashti AR, Wallace MC, Willinsky RA, Tymianski M, Schwartz ML, ter Brugge KG. Management and clinical outcome of posterior fossa arteriovenous malformations: report on a single-centre 15-year experience. Journal of Neurology, Neurosurgery, and Psychiatry. 80: 376-9. PMID 19028763 DOI: 10.1136/jnnp.2008.152710  1
2009 Da Costa L, Wallace MC, Ter Brugge KG, O'Kelly C, Willinsky RA, Tymianski M. The natural history and predictive features of hemorrhage from brain arteriovenous malformations Stroke. 40: 100-105. DOI: 10.1161/STROKEAHA.108.524678  1
2008 Soriano FX, Martel MA, Papadia S, Vaslin A, Baxter P, Rickman C, Forder J, Tymianski M, Duncan R, Aarts M, Clarke P, Wyllie DJ, Hardingham GE. Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10696-710. PMID 18923045 DOI: 10.1523/JNEUROSCI.1207-08.2008  1
2008 Sun HS, Doucette TA, Liu Y, Fang Y, Teves L, Aarts M, Ryan CL, Bernard PB, Lau A, Forder JP, Salter MW, Wang YT, Tasker RA, Tymianski M. Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat. Stroke; a Journal of Cerebral Circulation. 39: 2544-53. PMID 18617669 DOI: 10.1161/STROKEAHA.107.506048  1
2008 Besancon E, Guo S, Lok J, Tymianski M, Lo EH. Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke Trends in Pharmacological Sciences. 29: 268-275. PMID 18384889 DOI: 10.1016/j.tips.2008.02.003  1
2007 da Costa LB, Riva-Cambrin J, Tandon A, Tymianski M. Pituitary adenoma associated with intraventricular meningioma: case report. Skull Base : Official Journal of North American Skull Base Society ... [Et Al.]. 17: 347-51. PMID 18330434 DOI: 10.1055/s-2007-986440  1
2007 Lau AC, Cui H, Tymianski M. The use of propidium iodide to assess excitotoxic neuronal death in primary mixed cortical cultures. Methods in Molecular Biology (Clifton, N.J.). 399: 15-29. PMID 18309922 DOI: 10.1007/978-1-59745-504-6_2  1
2007 Wei WL, Sun HS, Olah ME, Sun X, Czerwinska E, Czerwinski W, Mori Y, Orser BA, Xiong ZG, Jackson MF, Tymianski M, MacDonald JF. TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proceedings of the National Academy of Sciences of the United States of America. 104: 16323-8. PMID 17913893 DOI: 10.1073/pnas.0701149104  1
2007 Cui H, Hayashi A, Sun HS, Belmares MP, Cobey C, Phan T, Schweizer J, Salter MW, Wang YT, Tasker RA, Garman D, Rabinowitz J, Lu PS, Tymianski M. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 9901-15. PMID 17855605 DOI: 10.1523/JNEUROSCI.1464-07.2007  1
2007 Liu Y, Wong TP, Aarts M, Rooyakkers A, Liu L, Lai TW, Wu DC, Lu J, Tymianski M, Craig AM, Wang YT. NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2846-57. PMID 17360906 DOI: 10.1523/JNEUROSCI.0116-07.2007  1
2006 Da Costa LB, Tymianski M. Symptomatic non-atherosclerotic bilateral extracranial vertebral artery occlusion treated with extracranial to intracranial bypass: Case report Arquivos De Neuro-Psiquiatria. 64. PMID 17119815  1
2006 Lau A, Arundine M, Sun HS, Jones M, Tymianski M. Inhibition of caspase-mediated apoptosis by peroxynitrite in traumatic brain injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11540-53. PMID 17093075 DOI: 10.1523/JNEUROSCI.3507-06.2006  1
2006 Da Costa LB, Valiante T, TerBrugge K, Tymianski M. Anterior ethmoidal artery aneurysm and intracerebral hemorrhage American Journal of Neuroradiology. 27: 1672-1674. PMID 16971611  1
2006 Spears J, TerBrugge KG, Moosavian M, Montanera W, Willinsky RA, Wallace MC, Tymianski M. A discriminative prediction model of neurological outcome for patients undergoing surgery of brain arteriovenous malformations Stroke. 37: 1457-1464. PMID 16690897 DOI: 10.1161/01.STR.0000222937.30216.13  1
2006 Taplin MA, Anthony R, Tymianski M, Wallace MC, Rutka JA. Transmastoid partial labyrinthectomy for brainstem vascular lesions: Clinical outcomes and assessment of postoperative cochleovestibular function Skull Base. 16: 133-144. DOI: 10.1055/s-2006-949514  1
2005 Mikulis DJ, Krolczyk G, Desal H, Logan W, DeVeber G, Dirks P, Tymianski M, Crawley A, Vesely A, Kassner A, Preiss D, Somogyi R, Fisher JA. Preoperative and postoperative mapping of cerebrovascular reactivity in moyamoya disease by using blood oxygen level-dependent magnetic resonance imaging Journal of Neurosurgery. 103: 347-355. PMID 16175867 DOI: 10.3171/jns.2005.103.2.0347  1
2005 Aarts MM, Tymianski M. TRPMs and neuronal cell death. PflüGers Archiv : European Journal of Physiology. 451: 243-9. PMID 16044308 DOI: 10.1007/s00424-005-1439-x  1
2005 Javadpour M, Jain H, Wallace MC, Willinsky RA, Ter Brugge KG, Tymianski M. Analysis of cost related to clinical and angiographic outcomes of aneurysm patients enrolled in the International Subarachnoid Aneurysm Trial in a North American setting Neurosurgery. 56: 886-893. PMID 15854235 DOI: 10.1227/01.NEU.0000157970.86782.DD  1
2005 Aarts MM, Tymianski M. TRPM7 and ischemic CNS injury. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 11: 116-23. PMID 15746380 DOI: 10.1177/1073858404272966  1
2005 Desal HA, Lee SK, Kim BS, Raoul S, Tymianski M, TerBrugge KG. Multiple de novo vascular malformations in relation to diffuse venous occlusive disease: A case report Neuroradiology. 47: 38-42. PMID 15654620 DOI: 10.1007/s00234-003-0971-7  1
2004 Arundine M, Aarts M, Lau A, Tymianski M. Vulnerability of central neurons to secondary insults after in vitro mechanical stretch. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8106-23. PMID 15371512 DOI: 10.1523/JNEUROSCI.1362-04.2004  1
2004 Arundine M, Tymianski M. Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cellular and Molecular Life Sciences : Cmls. 61: 657-68. PMID 15052409 DOI: 10.1007/s00018-003-3319-x  1
2004 Aarts MM, Tymianski M. Molecular mechanisms underlying specificity of excitotoxic signaling in neurons. Current Molecular Medicine. 4: 137-47. PMID 15032710 DOI: 10.2174/1566524043479202  1
2003 Aarts MM, Arundine M, Tymianski M. Novel concepts in excitotoxic neurodegeneration after stroke. Expert Reviews in Molecular Medicine. 5: 1-22. PMID 14987406 DOI: doi:10.1017/S1462399403007087  1
2003 Arundine M, Chopra GK, Wrong A, Lei S, Aarts MM, MacDonald JF, Tymianski M. Enhanced vulnerability to NMDA toxicity in sublethal traumatic neuronal injury in vitro. Journal of Neurotrauma. 20: 1377-95. PMID 14748985 DOI: 10.1089/089771503322686166  1
2003 Aarts M, Iihara K, Wei WL, Xiong ZG, Arundine M, Cerwinski W, MacDonald JF, Tymianski M. A key role for TRPM7 channels in anoxic neuronal death. Cell. 115: 863-77. PMID 14697204 DOI: 10.1016/S0092-8674(03)01017-1  1
2003 Aarts MM, Tymianski M. Peptide action in stroke therapy. Expert Opinion On Biological Therapy. 3: 1093-104. PMID 14519074 DOI: 10.1517/14712598.3.7.1093  1
2003 Aarts MM, Tymianski M. Novel treatment of excitotoxicity: targeted disruption of intracellular signalling from glutamate receptors. Biochemical Pharmacology. 66: 877-86. PMID 12963474 DOI: 10.1016/S0006-2952(03)00297-1  1
2003 Arundine M, Tymianski M. Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium. 34: 325-37. PMID 12909079 DOI: 10.1016/S0143-4160(03)00141-6  1
2003 Aarts MM, Arundine M, Tymianski M. Novel concepts in excitotoxic neurodegeneration after stroke Expert Reviews in Molecular Medicine. 5. DOI: 10.1017/S1462399403007087  1
2002 Aarts M, Liu Y, Liu L, Besshoh S, Arundine M, Gurd JW, Wang YT, Salter MW, Tymianski M. Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions. Science (New York, N.Y.). 298: 846-50. PMID 12399596 DOI: 10.1126/science.1072873  1
2002 Carlen PL, Pelletier MR, Ouanounou A, Tymianski M, Zhang L. Neuroprotective strategies in epilepsy Advances in Experimental Medicine and Biology. 497: 209-224. PMID 11993734  1
2001 Sattler R, Tymianski M. Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Molecular Neurobiology. 24: 107-29. PMID 11831548 DOI: 10.1385/MN:24:1-3:107  1
2001 Shehab ZP, Walsh RM, Thorp MA, Wallace MC, Tymianski M, Rutka JA. Partial labyrinthectomy approach for brainstem vascular lesions Journal of Otolaryngology. 30: 224-230. PMID 11771034  1
2001 Iihara K, Joo DT, Henderson J, Sattler R, Taverna FA, Lourensen S, Orser BA, Roder JC, Tymianski M. The influence of glutamate receptor 2 expression on excitotoxicity in Glur2 null mutant mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2224-39. PMID 11264298  1
2001 Porter PJ, Tymianski M, Muller PJ, TerBrugge KG. What to do when the doctor sees double: Identical twins with nearly identical aneurysms Interventional Neuroradiology. 7: 153-160.  1
2001 Willinsky RA, Goyal M, TerBrugge K, Montanera W, Wallace MC, Tymianski M. Embolisation of small (< 3 cm) brain arteriovenous malformations: Correlation of angiographic results to a proposed angioarchitecture grading system Interventional Neuroradiology. 7: 19-27.  1
2001 Taylor AG, Tymianski M, Ter Brugge K. A dissecting aneurysm of the posterior inferior cerebellar artery: A case report Interventional Neuroradiology. 7: 253-257.  1
2000 Walsh RM, Tymianski M, Wallace MC, Bath AP, Bance ML, Rutka JA. The transmatoid partial labyrinthectomy approach to medial skull base lesions Revue De Laryngologie Otologie Rhinologie. 121: 13-20. PMID 10865478  1
2000 Sattler R, Tymianski M. Molecular mechanisms of calcium-dependent excitotoxicity. Journal of Molecular Medicine (Berlin, Germany). 78: 3-13. PMID 10759025  1
2000 Sattler R, Xiong Z, Lu WY, MacDonald JF, Tymianski M. Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 22-33. PMID 10627577  1
2000 Al-Yamany M, Terbrugge KG, Willinsky R, Montanera W, Tymianski M, Wallace MC. Palliative embolisation of brain arteriovenous malformations presenting with progressive neurological deficit Interventional Neuroradiology. 6: 177-183.  1
1999 Redekop G, Willinsky R, Montanera W, TerBrugge K, Tymianski M, Wallace MC. Endovascular occlusion of basilar bifurcation aneurysms with electrolytically detachable coils Canadian Journal of Neurological Sciences. 26: 172-181. PMID 10451739  1
1999 Sattler R, Xiong Z, Lu WY, Hafner M, MacDonald JF, Tymianski M. Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science (New York, N.Y.). 284: 1845-8. PMID 10364559 DOI: 10.1126/science.284.5421.1845  1
1999 Paschen W, Tymianski M, Sattler R. Calcium neurotoxicity (multiple letters) Journal of Neurochemistry. 72: 2625-2626. PMID 10349876  1
1999 Norris JS, Valiante TA, Wallace MC, Willinsky RA, Montanera WJ, terBrugge KG, Tymianski M. A simple relationship between radiological arteriovenous malformation hemodynamics and clinical presentation: a prospective, blinded analysis of 31 cases. Journal of Neurosurgery. 90: 673-9. PMID 10193612  1
1998 Sattler R, Charlton MP, Hafner M, Tymianski M. Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity. Journal of Neurochemistry. 71: 2349-64. PMID 9832133  1
1998 Tymianski M, Sattler R, Zabramski JM, Spetzler RF. Characterization of neuroprotection from excitotoxicity by moderate and profound hypothermia in cultured cortical neurons unmasks a temperature-insensitive component of glutamate neurotoxicity. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 18: 848-67. PMID 9701346 DOI: 10.1097/00004647-199808000-00005  1
1998 Wallace MC, TerBrugge KG, Willinsky RA, Tymianski M, Montanera WJ. Treatment of aggressive dural arteriovenous fistulae by cerebral venous disconnection Journal of Neurosurgery. 88: 199A-200A.  1
1997 Wang Z, Tymianski M, Jones OT, Nedergaard M. Impact of cytoplasmic calcium buffering on the spatial and temporal characteristics of intercellular calcium signals in astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 7359-71. PMID 9295382  1
1997 Tymianski M, Sattler R, Bernstein G, Jones OT. Preparation, characterization and utility of a novel antibody for resolving the spatial and temporal dynamics of the calcium chelator BAPTA. Cell Calcium. 22: 111-20. PMID 9292229 DOI: 10.1016/S0143-4160(97)90111-1  1
1997 Sattler R, Charlton MP, Hafner M, Tymianski M. Determination of the time course and extent of neurotoxicity at defined temperatures in cultured neurons using a modified multiwell plate fluorescence scanner. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 17: 455-63. PMID 9143228 DOI: 10.1097/00004647-199704000-00011  1
1997 Abdel-Hamid KM, Tymianski M. Mechanisms and effects of intracellular calcium buffering on neuronal survival in organotypic hippocampal cultures exposed to anoxia/aglycemia or to excitotoxins Journal of Neuroscience. 17: 3538-3553. PMID 9133378  1
1997 Tymianski M, Bernstein GM, Abdel-Hamid KM, Sattler R, Velumian A, Carlen PL, Razavi H, Jones OT. A novel use for a carbodiimide compound for the fixation of fluorescent and non-fluorescent calcium indicators in situ following physiological experiments. Cell Calcium. 21: 175-83. PMID 9105727 DOI: 10.1016/S0143-4160(97)90042-7  1
1997 Holland MC, Tymianski M, Spetzler RF. What is recurrent carotid disease and should we treat it? Cerebrovascular Diseases. 7: 16-21.  1
1996 Spigelman I, Tymianski M, Wallace CM, Carlen PL, Velumian AA. Modulation of hippocampal synaptic transmission by low concentrations of cell-permeant Ca2+ chelators: effects of Ca2+ affinity, chelator structure and binding kinetics. Neuroscience. 75: 559-72. PMID 8931019 DOI: 10.1016/0306-4522(96)00283-7  1
1996 Ouanounou A, Zhang L, Tymianski M, Charlton MP, Wallace MC, Carlen PL. Accumulation and extrusion of permeant Ca2+ chelators in attenuation of synaptic transmission at hippocampal CA1 neurons. Neuroscience. 75: 99-109. PMID 8923526 DOI: 10.1016/0306-4522(96)00319-3  1
1996 Tymianski M. Cytosolic calcium concentrations and cell death in vitro Advances in Neurology. 71: 85-105. PMID 8790793  1
1996 Sattler R, Tymianski M, Feyaz I, Hafner M, Tator CH. Voltage-sensitive calcium channels mediate calcium entry into cultured mammalian sympathetic neurons following neurite transection. Brain Research. 719: 239-46. PMID 8782889 DOI: 10.1016/0006-8993(96)00125-4  1
1996 Tymianski M, Tator CH. Normal and abnormal calcium homeostasis in neurons: A basis for the pathophysiology of traumatic and ischemic central nervous system injury Neurosurgery. 38: 1176-1195. PMID 8727150 DOI: 10.1097/00006123-199606000-00028  1
1995 Zhang L, Pennefather P, Velumian A, Tymianski M, Charlton M, Carlen PL. Potentiation of a slow Ca(2+)-dependent K+ current by intracellular Ca2+ chelators in hippocampal CA1 neurons of rat brain slices. Journal of Neurophysiology. 74: 2225-41. PMID 8747186  1
1995 Tymianski M. Neuroprotection in vitro and in vivo by cell membrane-permeant Ca2+ chelators Clinical and Experimental Pharmacology and Physiology. 22: 299-300. PMID 7671447  1
1994 Tymianski M, Spigelman I, Zhang L, Carlen PL, Tator CH, Charlton MP, Wallace MC. Mechanism of action and persistence of neuroprotection by cell-permeant Ca2+ chelators. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 14: 911-23. PMID 7929656 DOI: 10.1038/jcbfm.1994.122  1
1994 Tymianski M, Wang LY, MacDonald JF. Alteration of neuronal calcium homeostasis and excitotoxic vulnerability by chronic depolarization. Brain Research. 648: 291-5. PMID 7922543 DOI: 10.1016/0006-8993(94)91129-0  1
1994 Tymianski M, Willinsky RA, Tator CH, Mikulis D, TerBrugge KG, Markson L. Embolization with temporary balloon occlusion of the internal carotid artery and in vivo proton spectroscopy improves radical removal of petrous-tentorial meningioma. Neurosurgery. 35: 974-7; discussion 97. PMID 7838353  1
1994 Tymianski M, Charlton MP, Carlen PL, Tator CH. Properties of neuroprotective cell-permeant Ca2+ chelators: effects on [Ca2+]i and glutamate neurotoxicity in vitro. Journal of Neurophysiology. 72: 1973-92. PMID 7823112  1
1993 Tymianski M, Wallace MC, Spigelman I, Uno M, Carlen PL, Tator CH, Charlton MP. Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo. Neuron. 11: 221-35. PMID 8102532 DOI: 10.1016/0896-6273(93)90180-Y  1
1993 Tymianski M, Charlton MP, Carlen PL, Tator CH. Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 2085-104. PMID 8097530  1
1993 Tymianski M, Charlton MP, Carlen PL, Tator CH. Secondary Ca2+ overload indicates early neuronal injury which precedes staining with viability indicators. Brain Research. 607: 319-23. PMID 7683241 DOI: 10.1016/0006-8993(93)91523-U  1
1989 Fehlings MG, Wong TH, Tator CH, Tymianski M. Effect of a direct current field on axons after experimental spinal cord injury. Canadian Journal of Surgery. Journal Canadien De Chirurgie. 32: 188-91. PMID 2785432  1
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