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Martin Lochner - Publications

Affiliations: 
2003 Chemistry Universität Basel, Basel, Basel-Stadt, Switzerland 
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23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Preti B, Suchankova A, Deganutti G, Leuenberger M, Barkan K, Manulak I, Huang X, Carvalho S, Ladds G, Lochner M. Discovery and Structure-Activity Relationship Studies of Novel Adenosine A Receptor-Selective Agonists. Journal of Medicinal Chemistry. 65: 14864-14890. PMID 36270633 DOI: 10.1021/acs.jmedchem.2c01414  0.683
2022 Wall MJ, Hill E, Huckstepp R, Barkan K, Deganutti G, Leuenberger M, Preti B, Winfield I, Carvalho S, Suchankova A, Wei H, Safitri D, Huang X, Imlach W, La Mache C, ... ... Lochner M, et al. Selective activation of Gαob by an adenosine A receptor agonist elicits analgesia without cardiorespiratory depression. Nature Communications. 13: 4150. PMID 35851064 DOI: 10.1038/s41467-022-31652-2  0.671
2021 Leuenberger M, Häusler S, Höhn V, Euler A, Stieger B, Lochner M. Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters. The Journal of Pharmacology and Experimental Therapeutics. PMID 33782042 DOI: 10.1124/jpet.120.000449  0.611
2021 Deganutti G, Barkan K, Preti B, Leuenberger M, Wall M, Frenguelli BG, Lochner M, Ladds G, Reynolds CA. Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor. Acs Pharmacology & Translational Science. 4: 314-326. PMID 33615181 DOI: 10.1021/acsptsci.0c00195  0.689
2020 Knight A, Hemmings JL, Winfield I, Leuenberger M, Frattini E, Frenguelli BG, Dowell SJ, Lochner M, Ladds G. Correction to Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity. Journal of Medicinal Chemistry. PMID 32870678 DOI: 10.1021/acs.jmedchem.0c01416  0.68
2019 Beswick P, Wahab B, Honey MA, Paradowski M, Jiang K, Lochner M, Murrell-Lagnado RD, Thompson AJ. A challenge finding P2X1 and P2X4 ligands. Neuropharmacology. 107674. PMID 31238045 DOI: 10.1016/J.Neuropharm.2019.107674  0.33
2018 Jack T, Leuenberger M, Ruepp MD, Vernekar SKV, Thompson AJ, Braga-Lagache S, Heller M, Lochner M. Mapping the Orthosteric Binding Site of the Human 5-HT Receptor Using Photo-crosslinking Antagonists. Acs Chemical Neuroscience. PMID 30149702 DOI: 10.1021/acschemneuro.8b00327  0.676
2017 Ruepp MD, Wei H, Leuenberger M, Lochner M, Thompson AJ. The binding orientations of structurally-related ligands can differ; A cautionary note. Neuropharmacology. PMID 28137449 DOI: 10.1016/j.neuropharm.2017.01.023  0.671
2017 Thompson AJ, Metzger S, Lochner M, Ruepp MD. The binding orientation of epibatidine at α7 nACh receptors. Neuropharmacology. PMID 28089847 DOI: 10.1016/j.neuropharm.2017.01.008  0.32
2016 Mu L, Müller Herde A, Rüefli PM, Sladojevich F, Milicevic Sephton S, Krämer SD, Thompson AJ, Schibli R, Ametamey SM, Lochner M. Synthesis and Pharmacological Evaluation of [(11)C]granisetron and [(18)F]fluoropalonosetron as PET Probes for 5-HT3 Receptor Imaging. Acs Chemical Neuroscience. PMID 27571447 DOI: 10.1021/acschemneuro.6b00192  0.591
2016 Lochner M, Thompson AJ. The muscarinic antagonists scopolamine and atropine are competitive antagonists at 5-HT3 receptors. Neuropharmacology. PMID 27108935 DOI: 10.1016/j.neuropharm.2016.04.027  0.315
2016 Leuenberger M, Ritler A, Simonin A, Hediger MA, Lochner M. Concise Asymmetric Synthesis and Pharmacological Characterization of All Stereoisomers of Glutamate Transporter Inhibitor TFB-TBOA and Synthesis of EAAT Photoaffinity Probes. Acs Chemical Neuroscience. 7: 534-9. PMID 26918289 DOI: 10.1021/acschemneuro.5b00311  0.63
2016 Knight A, Hemmings JL, Winfield I, Leuenberger M, Frattini E, Frenguelli BG, Dowell SJ, Lochner M, Ladds G. Discovery of Novel Adenosine Receptor Agonists that Exhibit Subtype Selectivity. Journal of Medicinal Chemistry. PMID 26756468 DOI: 10.1021/acs.jmedchem.5b01402  0.674
2015 Jack T, Simonin J, Ruepp MD, Thompson AJ, Gertsch J, Lochner M. Characterizing new fluorescent tools for studying 5-HT₃ receptor pharmacology. Neuropharmacology. 90: 63-73. PMID 25460187 DOI: 10.1016/j.neuropharm.2014.11.007  0.352
2014 Lochner M, Thompson AJ. The antimalarial drug proguanil is an antagonist at 5-HT3 receptors. The Journal of Pharmacology and Experimental Therapeutics. 351: 674-84. PMID 25277140 DOI: 10.1124/jpet.114.218461  0.309
2014 Jack T, Ruepp MD, Thompson AJ, Mühlemann O, Lochner M. Synthesis and characterization of photoaffinity probes that target the 5-HT3 receptor. Chimia. 68: 239-42. PMID 24983606 DOI: 10.2533/chimia.2014.239  0.345
2013 Hofer A, Kovacs G, Zappatini A, Leuenberger M, Hediger MA, Lochner M. Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. Bioorganic & Medicinal Chemistry. 21: 3202-13. PMID 23602525 DOI: 10.1016/j.bmc.2013.03.037  0.61
2013 Kanai Y, Clémençon B, Simonin A, Leuenberger M, Lochner M, Weisstanner M, Hediger MA. The SLC1 high-affinity glutamate and neutral amino acid transporter family. Molecular Aspects of Medicine. 34: 108-20. PMID 23506861 DOI: 10.1016/j.mam.2013.01.001  0.621
2010 Lochner M, Lummis SC. Agonists and antagonists bind to an A-A interface in the heteromeric 5-HT3AB receptor. Biophysical Journal. 98: 1494-502. PMID 20409468 DOI: 10.1016/j.bpj.2009.12.4313  0.366
2010 Vernekar SK, Hallaq HY, Clarkson G, Thompson AJ, Silvestri L, Lummis SC, Lochner M. Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives. Journal of Medicinal Chemistry. 53: 2324-8. PMID 20146481 DOI: 10.1021/jm901827x  0.328
2007 Thompson AJ, Lochner M, Lummis SC. The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT3 receptors. British Journal of Pharmacology. 151: 666-77. PMID 17502851 DOI: 10.1038/sj.bjp.0707238  0.308
2003 Lochner M, Meuwly M, Woggon WD. The origin of the low-spin character of the resting state of cytochrome P450cam investigated by means of active site analogues. Chemical Communications (Cambridge, England). 1330-2. PMID 12841227 DOI: 10.1039/B302274A  0.613
2003 Lochner M, Mu L, Woggon W. Remote Effects Modulating the Spin Equilibrium of the Resting State of Cytochrome P450cam –An Investigation Using Active Site Analogues Advanced Synthesis & Catalysis. 345: 743-765. DOI: 10.1002/ADSC.200303011  0.525
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