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Neil Freedman - Publications

Affiliations: 
Duke University, Durham, NC 
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Zhang L, Wu JH, Jean-Charles PY, Murali P, Zhang W, Jazic A, Kaur S, Nepliouev I, Stiber JA, Snow K, Freedman NJ, Shenoy SK. Phosphorylation of USP20 on Ser334 by IRAK-1 Promotes IL-1β-evoked Signaling in Vascular Smooth Muscle Cells and Vascular Inflammation. The Journal of Biological Chemistry. 104911. PMID 37311534 DOI: 10.1016/j.jbc.2023.104911  0.647
2018 Jean-Charles PY, Wu JH, Zhang L, Kaur S, Nepliouev I, Stiber JA, Brian L, Qi R, Wertman V, Shenoy SK, Freedman NJ. USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 38: 2295-2305. PMID 30354204 DOI: 10.1161/Atvbaha.118.311071  0.646
2018 Zhang L, Wu JH, Huang TQ, Nepliouev I, Brian L, Zhang Z, Wertman V, Rudemiller NP, McMahon TJ, Shenoy SK, Miller FJ, Crowley SD, Freedman NJ, Stiber JA. Drebrin Regulates Angiotensin II-Induced Aortic Remodeling. Cardiovascular Research. PMID 29931051 DOI: 10.1093/Cvr/Cvy151  0.6
2017 Zhang L, Wu JH, Otto JC, Gurley SB, Hauser ER, Shenoy SK, Nagi K, Brian L, Wertman V, Mattocks N, Lawson JH, Freedman NJ. Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells. Cardiovascular Research. PMID 29048463 DOI: 10.1093/Cvr/Cvx177  0.58
2017 Smith JS, Alagesan P, Desai NK, Pack TF, Wu JH, Inoue A, Freedman NJ, Rajagopal S. C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways. Molecular Pharmacology. PMID 28559424 DOI: 10.1124/Mol.117.108522  0.716
2017 Freedman NJ, Shenoy SK. Regulation of inflammation by β-arrestins: Not just receptor Tales. Cellular Signalling. PMID 28189586 DOI: 10.1016/J.Cellsig.2017.02.008  0.605
2016 Jean-Charles PY, Freedman NJ, Shenoy SK. Chapter Nine - Cellular Roles of Beta-Arrestins as Substrates and Adaptors of Ubiquitination and Deubiquitination. Progress in Molecular Biology and Translational Science. 141: 339-69. PMID 27378762 DOI: 10.1016/Bs.Pmbts.2016.04.003  0.632
2016 Jean-Charles PY, Zhang L, Wu JH, Han SO, Brian L, Freedman NJ, Shenoy SK. Ubiquitin-specific protease 20 Regulates the Reciprocal Functions of Beta-arrestin2 in Toll-like Receptor 4-promoted NFkappaB Activation. The Journal of Biological Chemistry. PMID 26839314 DOI: 10.1074/Jbc.M115.687129  0.619
2013 Wu JH, Fanaroff AC, Sharma KC, Smith LS, Brian L, Eipper BA, Mains RE, Freedman NJ, Zhang L. Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 702-8. PMID 23288169 DOI: 10.1161/ATVBAHA.112.300234  0.313
2012 Han SO, Xiao K, Kim J, Wu JH, Wisler JW, Nakamura N, Freedman NJ, Shenoy SK. MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors. The Journal of Cell Biology. 199: 817-30. PMID 23166351 DOI: 10.1083/Jcb.201208192  0.604
2012 Wu JH, Zhang L, Fanaroff AC, Cai X, Sharma KC, Brian L, Exum ST, Shenoy SK, Peppel K, Freedman NJ. G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 308-16. PMID 22095977 DOI: 10.1161/Atvbaha.111.239608  0.806
2010 Zhu S, Malhotra A, Zhang L, Deng S, Zhang T, Freedman NJ, Storms R, Peppel K, Goldschmidt-Clermont PJ, Dong C. Human umbilical cord blood endothelial progenitor cells decrease vein graft neointimal hyperplasia in SCID mice Atherosclerosis. 212: 63-69. PMID 20451204 DOI: 10.1016/J.Atherosclerosis.2010.04.018  0.765
2010 Zhang L, Connelly JJ, Peppel K, Brian L, Shah SH, Nelson S, Crosslin DR, Wang T, Allen A, Kraus WE, Gregory SG, Hauser ER, Freedman NJ. Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies. Human Molecular Genetics. 19: 2754-66. PMID 20421368 DOI: 10.1093/Hmg/Ddq172  0.756
2009 Cai X, Wu JH, Exum ST, Oppermann M, Premont RT, Shenoy SK, Freedman NJ. Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysis. Molecular Pharmacology. 75: 626-36. PMID 19092051 DOI: 10.1124/Mol.108.050278  0.835
2008 Shenoy SK, Xiao K, Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM. Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. The Journal of Biological Chemistry. 283: 22166-76. PMID 18544533 DOI: 10.1074/Jbc.M709668200  0.658
2008 Kim J, Zhang L, Peppel K, Wu JH, Zidar DA, Brian L, DeWire SM, Exum ST, Lefkowitz RJ, Freedman NJ. Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. Circulation Research. 103: 70-9. PMID 18519945 DOI: 10.1161/Circresaha.108.172338  0.784
2008 Zhang L, Sivashanmugam P, Wu JH, Brian L, Exum ST, Freedman NJ, Peppel K. Tumor necrosis factor receptor-2 signaling attenuates vein graft neointima formation by promoting endothelial recovery. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 284-9. PMID 18006858 DOI: 10.1161/ATVBAHA.107.151613  0.793
2007 Vinge LE, Andressen KW, Attramadal T, Andersen GØ, Ahmed MS, Peppel K, Koch WJ, Freedman NJ, Levy FO, Skomedal T, Osnes JB, Attramadal H. Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. Molecular Pharmacology. 72: 582-91. PMID 17573483 DOI: 10.1124/mol.107.035766  0.807
2007 Zhang L, Peppel K, Sivashanmugam P, Orman ES, Brian L, Exum ST, Freedman NJ. Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1087-94. PMID 17442899 DOI: 10.1161/ATVBAHA.0000261548.49790.63  0.778
2006 Cai X, Freedman NJ. New therapeutic possibilities for vein graft disease in the post-edifoligide era. Future Cardiology. 2: 493-501. PMID 19804184 DOI: 10.2217/14796678.2.4.493  0.661
2006 Wu JH, Goswami R, Cai X, Exum ST, Huang X, Zhang L, Brian L, Premont RT, Peppel K, Freedman NJ. Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2. The Journal of Biological Chemistry. 281: 37758-72. PMID 17018529 DOI: 10.1074/Jbc.M605756200  0.823
2005 Wu JH, Goswami R, Kim LK, Miller WE, Peppel K, Freedman NJ. The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition. The Journal of Biological Chemistry. 280: 31027-35. PMID 15994317 DOI: 10.1074/Jbc.M501473200  0.829
2005 Peppel K, Zhang L, Orman ES, Hagen PO, Amalfitano A, Brian L, Freedman NJ. Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms. Cardiovascular Research. 65: 674-82. PMID 15664394 DOI: 10.1016/J.Cardiores.2004.10.031  0.768
2004 Zhang L, Peppel K, Brian L, Chien L, Freedman NJ. Vein graft neointimal hyperplasia is exacerbated by tumor necrosis factor receptor-1 signaling in graft-intrinsic cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 2277-83. PMID 15486311 DOI: 10.1161/01.ATV.0000147766.68987.0d  0.785
2004 Hildreth KL, Wu JH, Barak LS, Exum ST, Kim LK, Peppel K, Freedman NJ. Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor. The Journal of Biological Chemistry. 279: 41775-82. PMID 15271984 DOI: 10.1074/jbc.M403274200  0.831
2004 Freedman NJ, Lefkowitz RJ. Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation. The Journal of Clinical Investigation. 113: 1379-82. PMID 15146232 DOI: 10.1172/JCI21748  0.402
2004 Zhang L, Freedman NJ, Brian L, Peppel K. Graft-extrinsic cells predominate in vein graft arterialization. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 470-6. PMID 14726410 DOI: 10.1161/01.ATV.0000116865.98067.31  0.76
2003 Wu JH, Peppel K, Nelson CD, Lin FT, Kohout TA, Miller WE, Exum ST, Freedman NJ. The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor. The Journal of Biological Chemistry. 278: 44238-45. PMID 12944399 DOI: 10.1074/Jbc.M309450200  0.761
2002 Peppel K, Zhang L, Huynh TT, Huang X, Jacobson A, Brian L, Exum ST, Hagen PO, Freedman NJ. Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells reduces neointimal hyperplasia. Journal of Molecular and Cellular Cardiology. 34: 1399-1409. PMID 12393000 DOI: 10.1006/jmcc.2002.2092  0.832
2002 Freedman NJ, Kim LK, Murray JP, Exum ST, Brian L, Wu JH, Peppel K. Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization. The Journal of Biological Chemistry. 277: 48261-9. PMID 12381737 DOI: 10.1074/jbc.M204431200  0.83
2002 Zhang L, Hagen PO, Kisslo J, Peppel K, Freedman NJ. Neointimal hyperplasia rapidly reaches steady state in a novel murine vein graft model. Journal of Vascular Surgery. 36: 824-32. PMID 12368745  0.75
2001 Liang M, Freedman NJ, Theiss CT, Liggett SB. Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. Biochemistry. 40: 15031-7. PMID 11732925 DOI: 10.1021/Bi011453Z  0.598
2000 Peppel K, Jacobson A, Huang X, Murray JP, Oppermann M, Freedman NJ. Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells attenuates mitogenic signaling via G protein-coupled and platelet-derived growth factor receptors. Circulation. 102: 793-9. PMID 10942749 DOI: 10.1161/01.CIR.102.7.793  0.82
1998 Pitcher JA, Freedman NJ, Lefkowitz RJ. G protein-coupled receptor kinases. Annual Review of Biochemistry. 67: 653-92. PMID 9759500 DOI: 10.1146/annurev.biochem.67.1.653  0.788
1997 Freedman NJ, Ament AS, Oppermann M, Stoffel RH, Exum ST, Lefkowitz RJ. Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity. The Journal of Biological Chemistry. 272: 17734-43. PMID 9211925 DOI: 10.1074/jbc.272.28.17734  0.501
1996 Oppermann M, Diversé-Pierluissi M, Drazner MH, Dyer SL, Freedman NJ, Peppel KC, Lefkowitz RJ. Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. Proceedings of the National Academy of Sciences of the United States of America. 93: 7649-54. PMID 8755530 DOI: 10.1073/Pnas.93.15.7649  0.824
1996 Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ. Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. The Journal of Biological Chemistry. 271: 13266-72. PMID 8662816  0.646
1995 Freedman NJ, Liggett SB, Drachman DE, Pei G, Caron MG, Lefkowitz RJ. Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. The Journal of Biological Chemistry. 270: 17953-61. PMID 7629102 DOI: 10.1074/Jbc.270.30.17953  0.766
1994 Ishii K, Chen J, Ishii M, Koch W, Freedman N, Lefkowitz R, Coughlin S. Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. Journal of Biological Chemistry. 269: 1125-1130. DOI: 10.1016/s0021-9258(17)42230-7  0.578
1994 Barak L, Tiberi M, Freedman N, Kwatra M, Lefkowitz R, Caron M. A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. Journal of Biological Chemistry. 269: 2790-2795. DOI: 10.1016/S0021-9258(17)42012-6  0.44
1993 Liggett SB, Freedman NJ, Schwinn DA, Lefkowitz RJ. Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 90: 3665-9. PMID 8386380 DOI: 10.1073/Pnas.90.8.3665  0.746
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